A tissue closure apparatus

Abstract

The application relates to the field of medical devices, in particular to a tissue closure device, which comprises a delivery catheter, an implant, a guide mechanism, a puncture mechanism and a positioning mechanism, the positioning mechanism can provide support for the puncture mechanism when the puncture mechanism punctures tissues back and forth, the puncture mechanism comprises an abutting tube, a first tube and a second tube, the guide mechanism is connected with the puncture mechanism, the puncture mechanism comprises the abutting tube, the first tube and the second tube, the guide mechanism can make the puncture mechanism puncture tissues according to a predetermined route, and the positions of the first tube and the second tube puncturing tissues are both located in the area of the positioning support; in the application, the first guide member and the second guide member can respectively guide the first tube and the second tube to puncture tissues according to the predetermined route, meanwhile, the positioning support can provide bidirectional support for the puncture mechanism when the puncture mechanism punctures tissues back and forth, the puncture precision is improved, and tissues can be prevented from being damaged.

Description

Technical Field

[0001] This application relates to the field of medical devices, and in particular to a device for tissue closure. Background Technology

[0002] The foramen ovale is a physiological passage in the atrial septum of the heart during embryonic development. Since the fetus lacks pulmonary circulation, oxygenated blood from the umbilical cord flows from the right atrium into the left atrium through the foramen ovale. After birth, as pulmonary circulation develops, the pressure in the left atrium increases, causing the secondary and primary septa to approach and fuse, gradually forming a permanent atrial septum. However, in some individuals, this fusion fails, resulting in patent foramen ovale (PFO). The traditional treatment for PFO is surgery. This surgical approach requires open-chest surgery. The main disadvantages of surgery are: the need for cardiopulmonary bypass, the potential for complications leading to death, significant surgical trauma, postoperative scarring, and high cost. With the development and improvement of interventional techniques, minimally invasive interventional treatment for PFO is now very mature. Minimally invasive interventional treatment has advantages such as no incision, minimal trauma, fewer complications, faster recovery, better efficacy, wider range of indications, and relatively lower cost. However, each method has its own set of problems.

[0003] Patent CN202111079433.7 discloses a closure device for tissue defects. The closure device includes a closure unit and a release unit. The closure unit includes a connecting unit and a locking unit connected to the connecting unit. The locking unit is located in the proximal region of the connecting unit, and the release unit is located in the proximal region of the locking unit. The connecting unit includes at least one or more connectors; the locking unit includes at least one or more locking elements. Operating the release unit rotates the locking elements and tightens the connecting unit, causing the locking elements to move closer together and self-lock, thereby closing the tissue defect. The locking unit and the release unit are an integral structure. When the locking elements self-lock, further operation of the release unit causes it to break off from the locking unit. In actual testing, this patented solution suffers from several drawbacks. Because the heart is constantly beating during the procedure, the device may shift during puncture. Furthermore, the lack of tissue support during puncture can easily cause tissue tearing and damage.

[0004] In summary, the existing technology has the following problems that urgently need to be solved: First, the existing technology does not provide pre-guided puncture points when puncturing tissue, resulting in deviations between the puncture point and the expected location; Second, there is no support for the tissue during puncture, which causes tearing and damage to the tissue. Summary of the Invention

[0005] This application is made in view of the above and other ideas.

[0006] One of the purposes of this application is to overcome the shortcomings of the prior art. In view of the problems that the puncture instruments in the prior art do not provide pre-guidance when puncturing tissue, resulting in deviation of the puncture point, and that the instruments cannot provide support during puncture, thus damaging the tissue, this application provides a tissue closure instrument.

[0007] The objective of this invention is achieved through the following solution:

[0008] An instrument for tissue closure includes a delivery catheter, an implant for closing tissue defects (i.e., secondary septal tissue and primary septal tissue), and a guiding mechanism, a puncture mechanism, and a positioning mechanism disposed within the delivery catheter. The positioning mechanism provides support for the puncture mechanism as it reciprocates through the tissue to be closed. The puncture mechanism includes a retaining tube and a first and second tube disposed within the retaining tube. The guiding mechanism includes a first guide and a second guide. The first guide connects the retaining tube and the positioning mechanism, and the second guide connects to the first tube. The first and second guides allow the puncture mechanism to puncture the tissue along a predetermined route, and the puncture sites of the first and second tubes are both located within the area of ​​the positioning support.

[0009] The objective of this invention can also be further achieved through the following technical solutions:

[0010] As a further improvement of the present invention, the positioning mechanism includes a connecting member, a positioning bracket disposed at the distal end of the connecting member, and a clamping member disposed on the connecting member. The distal end of the first guide member is connected to the clamping member. After the clamping member and the positioning bracket cooperate to clamp the secondary septum tissue, the abutment tube reaches the puncture position along the first guide member.

[0011] As a further improvement of the present invention, the abutment tube reaches the predetermined puncture position along the first guide, the abutment tube is on the right atrium side, and the upper region of the positioning mechanism is located on the left atrium secundum side, so that when the first tube punctures the secundum tissue, the upper region of the positioning bracket can provide support. After the first tube punctures the secundum tissue, the second guide is operated to make the first tube detour and abut against the primary septum tissue. The second tube extends from the first tube to puncture the primary septum tissue. When the second tube punctures the primary septum tissue, the lower region of the positioning bracket can provide support to prevent tissue tearing.

[0012] As a further improvement of the present invention, the distal end of the abutment tube is provided with a bending structure. After the abutment tube reaches the puncture position along the first guide, the abutment tube is pushed to bend the distal end of the abutment tube. The distal portion of the abutment tube is perpendicular to the clamp (to facilitate the first tube to puncture the secondary septum tissue).

[0013] In another embodiment, the positioning mechanism includes a connecting member disposed within the delivery conduit, a positioning bracket disposed at the distal end of the connecting member, and a clamping member disposed at the distal end of the delivery conduit. The puncture mechanism includes an abutment tube, a first tube and a second tube disposed within the abutment tube, and the guiding mechanism is a wire or thread. The distal end of the abutment tube is connected to the clamping member, and the guiding mechanism is connected to the distal end of the first tube.

[0014] As a further improvement of the present invention, an angle α is formed between the clamping member and the positioning bracket, and an angle b is formed between the positioning bracket and the connecting member, and the angle α is equal to the angle b. The advantage of this design is that the clamping member and the positioning bracket are parallel, which allows the first tube to be perpendicular to the secondary septum tissue, and the stroke through the secondary septum tissue is minimized, and the force required for puncture is also minimized. At the same time, after puncturing the left atrium, only a 180° bend is needed to fit the primary septum tissue and achieve puncture, with a low risk of interference with the left atrium.

[0015] As a further improvement of the present invention, the distal end of the first pipe is provided with a bending section, and the distal end of the second guide is fixed to the distal end of the bending section; wherein, after the distal end of the first pipe passes through the secondary septum, the second guide cooperates with the bending section to make the distal end of the first pipe detour and abut against the primary septum.

[0016] As a further improvement of the present invention, the guiding mechanism includes a first guiding member and a second guiding member. The first guiding member is connected to the abutment tube and the positioning mechanism, and the second guiding member is connected to the second tube. During surgery, the abutment tube moves along the first guiding member to the predetermined puncture position. After the distal end of the first tube punctures the septal tissue, the second tube extends out from the first tube and cooperates with the second guiding member to make the second tube detour to puncture the primary septal tissue. The distal end of the second tube is provided with a flexible segment, and the distal end of the second guiding member is fixed to the distal end of the flexible segment. This allows the second guiding member to pull the flexible segment after the second tube extends out from the first tube, causing the distal part of the second tube to bend and abut against the primary septal tissue.

[0017] As a further improvement of the present invention, the second tube is provided with an ejector tube for ejecting the implant. The distal portion of the ejector tube has a predetermined shape, which is arc-shaped, and the radius of curvature of the ejector tube is greater than the radius of curvature of the second tube.

[0018] As a further improvement of the present invention, the positioning bracket is hinged to the connecting member, wherein after the positioning bracket reaches the target position, the positioning bracket can conform to the tunnel shape of PFO, making it fit the tissue better, which is beneficial to adjust to the optimal puncture angle during puncture, and the included angle between the positioning bracket and the connecting member is 30°-45°.

[0019] As a further improvement of the present invention, the positioning bracket has an H-shaped structure, and the puncture point of the first tube puncturing the secondary septum is located in the upper region of the positioning bracket, while the puncture point of the second tube puncturing the primary septum is located in the lower region of the positioning bracket.

[0020] Compared with the prior art, the advantages of the technical solution of this application include at least the following:

[0021] 1. Existing delivery systems lack pre-guided insertion during tissue puncture, leading to deviations in puncture site location. Furthermore, the absence of components providing adequate support to the puncture mechanism during puncture results in positional shifts and poor puncture outcomes. According to a concept proposed in this application, a first guide and a second guide can respectively guide the first and second tubes along predetermined routes to puncture the secondary and primary septal tissues, ensuring that the puncture sites of both tubes are within the area of ​​the positioning support. This allows the positioning support to provide effective support for the puncture mechanism as it reciprocates through the tissue, ensuring the puncture site remains consistent with expectations while preventing tissue tearing during puncture, thus possessing significant clinical implications.

[0022] 2. According to a concept of this application, an angle α is formed between the clamping member and the positioning bracket, and an angle b is formed between the positioning bracket and the connecting member, and angle α is equal to angle b. The advantage of this design is that the clamping member and the positioning bracket are parallel, which allows the first tube to be perpendicular to the secondary septum tissue, and the stroke through the secondary septum tissue is minimized, and the force required for puncture is also minimized. At the same time, after puncturing the left atrium, only a 180° bend is needed to fit the primary septum tissue and achieve puncture, with a low risk of interference with the left atrium.

[0023] 3. According to a concept of this application, the positioning bracket is hinged to the distal end of the connecting member. When the positioning bracket is delivered to the foramen ovale, the positioning bracket can conform to the tunnel shape of the PFO, making it fit the tissue better. This facilitates adjustment to the optimal puncture angle during puncture. Furthermore, the positioning bracket is designed with an H-shaped rod structure, so that during puncture, the rods on both sides can provide sufficient support and provide a puncture channel for the puncture mechanism, making the puncture more accurate.

[0024] 4. According to a concept of this application, the distal end of the abutment fitting is fixed to the clamp, which reduces the guiding process and saves surgical time.

[0025] The embodiments of this application can achieve other advantageous technical effects not listed one by one, which may be partially described below; and these other technical effects can be expected and understood by those skilled in the art after reading this application. Attached Figure Description

[0026] The above-described features and advantages of these embodiments, as well as other features and advantages, and the ways in which they are implemented, will become more apparent from the following description in conjunction with the accompanying drawings; and embodiments of this application can be better understood, in which:

[0027] Figure 1a and 1b This is a schematic diagram of the overall structure of a tissue closure device according to the present invention.

[0028] Figure 2a and Figure 2b This is a schematic diagram of the puncture mechanism of the present invention, wherein... Figure 2b This is a schematic diagram showing the status of the second fitting and the ejector pipe.

[0029] Figure 3a and 3b This is a schematic diagram of the positioning mechanism of the present invention.

[0030] Figures 4a-4k This is a schematic diagram of the operation process of the present invention, wherein... Figures 4d-4h This is a schematic diagram illustrating the puncture principle of the puncture mechanism of the present invention. Figure 4h for Figure 4g Right view of the puncture mechanism.

[0031] Figures 5a-5c This is a schematic diagram of another embodiment of the present invention.

[0032] Figures 6a-6c This is a schematic diagram of another embodiment of the present invention.

[0033] The features represented by the numbers in the attached diagram are as follows:

[0034] 1-Delivery catheter, 2-Implant, 3-Guiding mechanism, 31-First guide, 32-Second guide, 4-Punch mechanism, 41-Abutting tube, 411-Bending structure, 42-First tube, 421-Adjusting section, 43-Second tube, 5-Positioning mechanism, 51-Connecting component, 52-Positioning bracket, 521-Upper region, 522-Lower region, 53-Clamping component, 6-Ejection tube, 7-Flexible section. Detailed Implementation

[0035] The details of one or more embodiments of this application will be set forth in the following description of the accompanying drawings and specific embodiments. Other features, objects, and advantages of this application will become clear from these descriptions, drawings, and claims.

[0036] It should be understood that the phrases and terms used in this document are for descriptive purposes and should not be considered restrictive. The use of “including,” “contains,” or “has,” and their variations, in this document is intended to include, in an open-ended manner, the items listed thereafter, their equivalents, and any additional items.

[0037] The present application will now be described in more detail with reference to various embodiments and examples of several aspects thereof.

[0038] In this application, the terms "proximal" or "proximal" refer to the end or side closer to the surgeon, and "distal" or "distal" refer to the end or side farther from the surgeon.

[0039] In this application, the term "reciprocating puncture" is defined as puncturing one tissue and then puncturing another tissue in a roundabout way.

[0040] In the prior art, the puncture instruments do not provide support for the secondary septal tissue and may deviate from the intended position during the operation.

[0041] One of the objectives of the embodiments described below is to address the aforementioned deficiencies, as well as other problems.

[0042] Example 1

[0043] like Figure 1a and 1bAs shown, the present invention, when used to close the foramen ovale tissue, illustrates a tissue closure device 4 according to an embodiment of this application, including a delivery catheter 1, an implant 2 for closing tissue defects (i.e., secondary septal tissue and primary septal tissue), and a guiding mechanism 3, a puncture mechanism 4, and a positioning mechanism 5 disposed within the delivery catheter 1. The positioning mechanism 5 includes a connecting member 51, a positioning bracket 52 disposed at the distal end of the connecting member 51, and a clamping member 53 disposed on the connecting member 51. The puncture mechanism 4 includes an abutment tube 41, a first tube 42 disposed within the abutment tube 41, and a second tube 43, as shown. Figure 2a As shown, the guiding mechanism 3 includes a first guide 31 and a second guide 32. The first guide 31 connects the abutment tube 41 and the positioning bracket 52. Specifically, the distal end of the first guide 31 is connected to the clamping member 53, and the second guide 32 is connected to the first tube 42. After the clamping member 53 and the positioning bracket 52 clamp the secondary septum, the abutment tube 41 travels along the first guide 31 to the puncture position. Figure 4d and 4e As shown, after the first tube 42 passes through the secondary septum, the second tube 43 extends from the first tube 42. The second guide 32 guides the first tube 42 to cooperate and cause the bending section 421 to bend and detour against the primary septum. Subsequently, pushing the second tube 43 can puncture the primary septum, as... Figures 4f to 4h As shown; and, the positions of the first tube 42 and the second tube 43 for puncturing tissue are both located within the area of ​​the positioning bracket 52, so that the positioning bracket 52 can provide support for the first tube 42 and the second tube 43 to puncture the secondary septum and the primary septum.

[0044] In this first embodiment, the abutment tube 41 travels along the first guide 31 to the predetermined puncture position. The abutment tube 41 is on the right atrium side, and the upper region 521 of the positioning mechanism 5 is located on the left atrium side of the secundum. This allows the upper region 521 of the positioning bracket 52 to provide support when the first tube 42 punctures the secundum tissue. After the first tube 42 punctures the secundum tissue, the second guide 32 is operated to make the first tube 42 abut against the primary septum tissue along a predetermined route, and further push the second tube 43 to puncture the primary septum tissue. Furthermore, when the second tube 43 punctures the primary septum tissue, the lower region 522 of the positioning bracket 52 provides support to prevent tissue tearing. Figures 4d-4h As shown.

[0045] In this first embodiment, the distal end of the abutment tube 41 is provided with a bending structure 411. After the abutment tube 41 reaches the puncture position along the first guide 31, the abutment tube 41 is further pushed to bend the distal end of the abutment tube 41. The distal portion of the abutment tube 41 is perpendicular to the clamping member 53 (to facilitate the first tube 42 to puncture the secondary septum tissue). Figure 4d and 4e As shown.

[0046] In this first embodiment, an angle α is formed between the clamping member 53 and the positioning bracket 52, and an angle b is formed between the positioning bracket 52 and the connecting member 51. Furthermore, angle α is equal to angle b. The advantage of this design is that the clamping member 53 and the positioning bracket 52 are parallel, which allows the first tube 42 to be perpendicularly punctured into the secondary septum. Moreover, the stroke through the secondary septum is minimized, and the force required for puncture is also minimized. At the same time, after puncturing into the left atrium, only a 180° bend is needed to conform to the primary septum and achieve puncture, with a low risk of interference with the left atrium.

[0047] In this first embodiment, the distal end of the first pipe fitting 42 is provided with a bending section 421, and the two ends of the second guide member 32 are respectively fixed to the two ends of the bending section 421, such as... Figure 1b As shown; wherein, after the first tube 42 punctures the secondary septum, the bending section 421 on the first tube 42 cooperates with the second guide 32 to make the distal end of the first tube 42 detour and abut against the primary septum, and then pushes the second tube 43 to puncture the primary septum. Furthermore, the diameter of the bending section 421 after bending is greater than the length of the line connecting the puncture points of the first tube 42 and the second tube 43. This ensures that the positioning bracket 52 can provide support for both the first tube 42 and the second tube 43 when puncturing the tissue, avoiding damage to the tissue during puncture.

[0048] In this first embodiment, the second tube 43 is pre-installed with an ejector tube 6 for pushing out the implant 2, such as... Figure 2b As shown, the distal portion of the ejector tube 6 has a predetermined shape, and the predetermined shape is arc-shaped, and the radius of curvature of the ejector tube 6 is greater than the radius of curvature of the second tube 43.

[0049] In this first embodiment, the positioning bracket 52 is hinged to the connecting member 51. After the positioning bracket 52 reaches the target position, the positioning bracket 52 can conform to the tunnel shape of PFO, making it fit the tissue better, which is conducive to adjusting to the optimal puncture angle during puncture. Furthermore, the included angle between the positioning bracket 52 and the connecting member 51 is 30°.

[0050] In another embodiment, the angle between the positioning bracket 52 and the connecting member 51 is 45°, and the positioning bracket 52 can also fit the heart tissue well to complete the positioning; the angle changes according to the different physiological structures of the patients. The positioning bracket 52 and the connecting member 51 are hinged, so they can conform to and fit their different physiological and anatomical structures.

[0051] In this first embodiment, the positioning bracket 52 has an H-shaped structure, such as... Figure 3a As shown, the puncture point of the first tube 42 puncturing the secondary septum is located in the upper region 521 of the positioning bracket 52, and the puncture point of the second tube 43 puncturing the primary septum is located in the lower region 522 of the positioning bracket 52. Figure 4g and 4h As shown.

[0052] The exemplary operation process of the puncture mechanism 4 in this embodiment is as follows:

[0053] (1) Establish the PFO access route, leave a guidewire, and ensure that the distal end of the guidewire is in the left atrium. Then, guide the delivery catheter 1 through the femoral vein approach into the right atrium along the guidewire, and push it to the position of the patent foramen ovale between the secondary septum and the primary septum near the interatrial septum, ensuring that the distal end of the delivery catheter 1 is in the left atrium. Figure 4a As shown;

[0054] (2) Retract the delivery catheter 1 so that its positioning bracket 52 returns to the preset shape. At this time, the positioning bracket 52 is located between the secondary septum and the primary septum. Then, operate the clamping member 53 to cooperate with the positioning bracket 52 and clamp the secondary septum tissue, as shown. Figure 4b and 4c As shown;

[0055] (3) Operate the abutment fitting 41 to guide it along the first guide 31 and abut against the clamping member 53. Further push the abutment fitting 41 to bend its distal end and perpendicularly abut against the secondary septum. Operate the first fitting 42 to puncture the secondary septum. After the first fitting 42 passes through the secondary septum, operate the second guide 32 to bend its bending section 421 and detour to abut against the primary septum. Push the second fitting 43 to puncture the primary septum. After puncture, retract the clamping member 53 and insert it into the delivery catheter 1. Figures 4d to 4i As shown;

[0056] (4) Observe the position of the foramen ovale in the right atrium to detect any shunt. Pull the implant 2 until no blood flow passes between the primary and secondary septa. Finally, cut the suture connected to the implant 2 to complete the surgery. Figure 4j and 4k As shown.

[0057] Example 2

[0058] Example 2 is largely the same as Example 1, except that in this example it is connected to the second tube and guided to the primary septum along a predetermined route.

[0059] In this embodiment, the guiding mechanism 3a includes a first guiding member 31a and a second guiding member 32a. The first guiding member 31a is connected to the abutting pipe 41a and the positioning mechanism 5a, and the second guiding member 32a is connected to the second pipe 43a. Figure 5a As shown, during the surgery, the abutment tube 41a moves along the first guide 31a to the predetermined puncture position. After the distal end of the first tube 42a punctures the secondary septum tissue, the distal end of the first tube 42a is located in the left atrium. Furthermore, the distal end of the first tube 42a has a certain rigidity (so that the distal end of the first tube 42a can provide a certain resistance force when the second tube 43a is punctured). Subsequently, the second tube 43a extends from the first tube 42a and cooperates with the second guide 32a, allowing the second tube 43a to indirectly puncture the primary septum tissue. Figure 5b and 5c As shown, the distal end of the second tube 43a is provided with a flexible section 7, and the two ends of the second guide 43a are respectively fixed to the two ends of the flexible section 7. This allows the second guide 32a to pull the flexible section 7 after the second tube 43a extends out of the first tube 42a, causing the distal part of the second tube 43a to bend and abut against the primary septum.

[0060] In this regard, the relevant construction and concept of Embodiment 2 are similar to those of Embodiment 1, and therefore will not be described again here.

[0061] Example 3

[0062] Example 3 is largely the same as Example 1, except that the guide mechanism 3 in this example is only a line or wire used to control the bending of the first pipe 42, and the clamping member 53 is located at the far end of the delivery conduit 1.

[0063] In this embodiment, the positioning mechanism 5 includes a connecting member 51 disposed within the delivery conduit 1, a positioning bracket 52 disposed at the distal end of the connecting member 51, and a clamping member 53 disposed at the distal end of the delivery conduit 1. The puncture mechanism 4 includes abutting tube 41, a first tube 42 disposed within the abutting tube 41, and a second tube 43. The guiding mechanism 3 is a wire or thread, wherein the distal end of the abutting tube 41 is connected to the clamping member 53, and the guiding mechanism 3 is connected to the distal end of the first tube 42. Figure 6aAs shown; during the procedure, by pulling the abutment tube 41, the clamping member 53 opens and forms a certain angle with the positioning bracket 52. Then, the secondary septum is clamped between the clamping member 53 and the positioning bracket 52. The abutment tube 41 is pushed upwards, causing the distal end of the abutment tube 41 to bend and abut against the secondary septum, as shown. Figure 6b and 6c As shown, when the first tube 42 extends out from the abutting tube 41 and punctures the secondary septum, the guide mechanism 3 is pulled to make the distal end of the first tube 42 detour and abut against the primary septum, and then the second tube 43 extends out from the first tube 42 and punctures the primary septum.

[0064] In this regard, the relevant construction and concept of Embodiment 3 are similar to those of Embodiment 1, and therefore will not be described again here.

[0065] The foregoing description of several embodiments of this application has been provided for illustrative purposes. This foregoing description is not intended to be exhaustive, nor is it intended to limit the application to the precise configurations, constructions, and / or steps disclosed; obviously, many modifications and variations can be made in light of the teachings above. The scope of the invention and all its equivalents are intended to be defined by the appended claims.

Claims

1. A tissue closure device, comprising a delivery catheter, an implant for closing tissue defects, and a guiding mechanism, a puncture mechanism, and a positioning mechanism disposed within the delivery catheter, wherein the positioning mechanism provides support for the puncture mechanism during reciprocating punctures of the tissue to be closed, characterized in that: The guiding mechanism is connected to the puncture mechanism, wherein the guiding mechanism enables the puncture mechanism to puncture tissue along a predetermined route, and the positioning mechanism includes a connecting member, a positioning bracket disposed at the distal end of the connecting member, and a clamping member disposed on the connecting member. The puncture mechanism's reciprocating puncture positions are both located within the area of ​​the positioning bracket. The puncture mechanism includes abutment tube, a first tube and a second tube disposed within the abutment tube, and the guiding mechanism includes a first guide and a second guide. The first guide connects the abutment tube and the positioning mechanism, and the second guide is connected to the first tube.

2. The tissue closure device according to claim 1, characterized in that: The second guide is connected to the second pipe fitting.

3. The tissue closure device according to claim 1, characterized in that: The abutting tube moves along the first guide to the predetermined puncture position. After the first tube punctures the secondary septum, the second guide is operated to make the first tube detour and abut against the primary septum. The second tube extends out from the first tube to puncture the primary septum.

4. A tissue closure device according to claim 2, characterized in that: The abutment tube reaches the predetermined puncture position along the first guide. After the distal end of the first tube punctures the secondary septum, the second tube extends out from the first tube and cooperates with the second guide so that the second tube detours to puncture the primary septum.

5. A tissue closure device according to claim 1, characterized in that: The distal end of the first guide is connected to the clamping member, wherein after the clamping member and the positioning bracket clamp the secondary septum, the abutment tube reaches the puncture position along the first guide.

6. A tissue closure device according to claim 1, characterized in that: The positioning mechanism includes a connecting member disposed within the delivery conduit, a positioning bracket disposed at the distal end of the connecting member, and a clamping member disposed at the distal end of the delivery conduit. The puncture mechanism includes a contact tube, a first tube and a second tube disposed within the contact tube, wherein the distal end of the contact tube is connected to the clamping member, and the guiding mechanism is connected to the distal end of the first tube.

7. A tissue closure device according to claim 5, characterized in that: The distal end of the abutment tube is provided with a bending structure. After the abutment tube reaches the puncture position along the first guide, the abutment tube is pushed to bend the distal end of the abutment tube. The distal portion of the abutment tube is perpendicular to the clamping member.

8. A tissue closure device according to claim 5, characterized in that: An angle α is formed between the clamping member and the positioning bracket, and an angle b is formed between the positioning bracket and the connecting member, wherein the angle α is equal to the angle b.

9. A tissue closure device according to claim 1, characterized in that: The first pipe fitting has a bending section at its distal end, and the distal end of the second guide is fixed to the distal end of the bending section.

10. A tissue closure device according to claim 2, characterized in that: The distal end of the second pipe fitting is provided with a flexible section, and the distal end of the second guide is fixed to the distal end of the flexible section.

11. A tissue closure device according to claim 9, characterized in that: After the distal end of the first pipe passes through the secondary diaphragm, the second guide cooperates with the bending section to make the distal end of the first pipe detour and abut against the primary diaphragm.

12. A tissue closure device according to claim 1, characterized in that: The positioning bracket has an H-shaped structure, and the puncture point of the first tube puncturing the secondary septum is located in the upper region of the positioning bracket, while the puncture point of the second tube puncturing the primary septum is located in the lower region of the positioning bracket.

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