Traditional Chinese medicine for treating scar

Abstract

The application discloses a traditional Chinese medicine for treating scars, which comprises the following components in terms of weight: white chrysanthemum 10-15 parts, canty caterpillar fungus 8-12 parts, clove 20-30 parts, peach kernel 4-8 parts, soapberry 3-5 parts, dandelion 20-40 parts, schizonepeta 6-8 parts, salvia miltiorrhiza 8-12 parts, rhubarb 3-5 parts and licorice 6-10 parts. The application can obviously improve superficial scars and hypertrophic scars within one month, soften scar tissues, promote epithelialization of scar tissues and normalization of skin gland tissue secretion, disperse local melanocyte aggregation, and increase skin gloss and skin elasticity.

Description

Technical Field

[0001] This invention relates to a traditional Chinese medicine composition, and more particularly to a traditional Chinese medicine for treating scars. Background Technology

[0002] Scars are a general term for the changes in the appearance and histopathology of normal skin tissue caused by the healing of various traumas. They are an inevitable product of the human body's wound repair process. When scar growth exceeds a certain limit, various complications will occur, such as damage to appearance and functional impairment, causing great physical and mental pain to patients, especially scars left after burns, scalds, and severe trauma. At present, scar treatment is divided into non-surgical treatment and surgical treatment. Among them, non-surgical Western medicine methods include: (1) Pressure therapy: applying pressure with a special pressure sleeve, which is suitable for patients with large scar areas who are not suitable for radiotherapy and local drug treatment. This method is not very effective for active keloids, but it can reduce the dosage of postoperative radiotherapy and injection. (2) Chemotherapy: using long-acting steroid preparations, directly injected into the scar, thereby inhibiting excessive collagen and achieving the effect of scar degeneration. The main side effects include skin atrophy, depigmentation, telangiectasia, necrosis, ulceration, and Cushing's syndrome. Other chemical drugs such as cytotoxins and immunosuppressants have been reported, but they have serious side effects. (3) Radiotherapy: Primarily for keloids. The method involves early (within 24 hours) irradiation with electron beams or X-rays after keloid excision, which can reduce postoperative recurrence and improve the cure rate. Due to the special nature of radiation, it can increase the incidence of malignant tumors. Therefore, this method is mainly used for late-stage keloids and when other methods are ineffective. (4) Laser therapy: A newly emerging treatment method in clinical practice, suitable for flat scars without obvious functional impairment, and atrophic scars of varying sizes and heights left after healing from smallpox, chickenpox, and acne. Lasers of various frequencies are used to irradiate the scar tissue, causing it to vaporize and eliminate the scar and abnormal skin pigmentation on it. (5) Other treatments such as cryotherapy, paraffin wax therapy, iontophoresis, and ultrasound have varying efficacy reports for hypertrophic scars and keloids.

[0003] It is evident that current Western non-surgical treatments for scars primarily focus on inhibiting abnormal proliferation of fibrous tissue within the scar tissue. They do not address the relationship between scar formation and the overall internal environment, thus exhibiting significant limitations. Furthermore, the treatment cycle is lengthy, typically 6–12 months, ultimately requiring the induction or waiting for the body's own repair functions to take effect. This results in considerable uncertainty regarding the treatment outcome, and patients often experience a degree of discomfort, making it difficult to achieve satisfactory results.

[0004] Traditional Chinese medicine (TCM) theory, based on a holistic approach, posits that scar tissue is a pathological product resulting from damage to the skin's integrity and function caused by various factors. Skin problems stem from both exogenous factors, such as thermal damage and trauma, and endogenous factors, such as impaired functional support of the five internal organs for the skin. Therefore, a holistic approach should be adopted, considering both the damage caused by exogenous factors and the impact of endogenous factors on the skin. The selected TCM ingredients should possess functions such as cleansing the skin, clearing the meridians, promoting blood circulation, and facilitating the overall circulation between the skin and internal organs, thereby regulating the internal environment of the scarred skin, normalizing it, and ultimately achieving the goal of treating scars. For example, invention patent application CN 106214974 A discloses a traditional Chinese medicine composition for scar suppression and whitening, the ingredients of which include Bletilla striata, Angelica dahurica, Bombyx batryticatus, Aconitum carmichaelii, Atractylodes macrocephala, Dictamnus dasycarpus, Syzygium aromaticum, Carthamus tinctorius, Rosa rugosa, Glycyrrhiza uralensis, and Borneol. This traditional Chinese medicine composition is mainly used to treat pigmented scars left after the healing of shallow wounds. It has the effect of reducing the area of ​​the scar and lightening its color, but the onset time is long and it cannot completely eliminate the scar. At the same time, it has not shown a significant inhibitory effect on hypertrophic scars. Summary of the Invention

[0005] The purpose of this invention is to provide a traditional Chinese medicine for treating scars. This medicine has a fast onset of action, is painless and has no side effects during the treatment process, and can significantly improve superficial and hypertrophic scars.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A traditional Chinese medicine for treating scars comprises the following components by weight: 10-15 parts white chrysanthemum, 8-12 parts silkworm pupae, 20-30 parts cloves, 4-8 parts peach kernels, 3-5 parts soap pods, 20-40 parts dandelion, 6-8 parts schizonepeta, 8-12 parts salvia miltiorrhiza, 3-5 parts rhubarb, and 6-10 parts licorice.

[0008] The preferred components are: 12 parts white chrysanthemum, 10 parts silkworm, 25 parts clove, 6 parts peach kernel, 4 parts soapberry, 30 parts dandelion, 7 parts schizonepeta, 10 parts salvia miltiorrhiza, 4 parts rhubarb, and 8 parts licorice.

[0009] The dosage form of the traditional Chinese medicine is powder, solution, ointment, or essence.

[0010] The powder is prepared as follows: the Chinese herbal medicine components are mixed and ground into powder using an ultrafine grinder, passed through a 120-mesh sieve three times, sterilized by cobalt-60 irradiation, and then packaged for later use.

[0011] The solution is prepared as follows: the Chinese herbal medicine components are mixed, purified water is added and boiled, the distillate is extracted by distillation, sterilized by cobalt-60 irradiation, and then packaged for later use.

[0012] The ointment is prepared as follows: the Chinese herbal components are mixed, purified water is added and boiled, the distillate is extracted by distillation, honey is added to the distillate and boiled into an ointment, sterilized by cobalt-60 irradiation and then packaged for later use.

[0013] The preparation method of the essence is as follows: after mixing the Chinese herbal medicine components, the main essence of the prescription is extracted by pressing and percolation, sterilized by cobalt-60 irradiation, and then packaged for later use.

[0014] In the above technical solution:

[0015] White chrysanthemums contain volatile oils, flavonoids, vitamins A, E, and B1, as well as 17 kinds of amino acids and various trace elements. They have antibacterial, antiviral, anti-inflammatory, and anti-aging effects, and can improve blood circulation. White chrysanthemums also contain abundant essential oils and chrysanthemum pigments, which can effectively inhibit the production of melanin in the skin, smooth epidermal cells, remove wrinkles, and make facial skin white and tender.

[0016] Silkworm pupae have the effect of stimulating the adrenal cortex and contain a variety of proteins, trace elements and amino acids, thus having a good nourishing effect on the skin.

[0017] Clove oil, contained in cloves, has antibacterial, antiviral, and free radical scavenging effects. As an aromatic traditional Chinese medicine, it also promotes the absorption of the active ingredients of other drugs.

[0018] Peach kernels contain amygdalin, amygdalinase, lactase, allantoinase, vitamin B1, and a large amount of unsaturated fatty acids. Pharmacological studies have shown that peach kernels have the effects of dilating peripheral blood vessels, anticoagulation, and anti-inflammation.

[0019] Soap pods act as surfactants, helping to remove oil from the skin and hair and increasing the skin's absorption of other nutrients.

[0020] Dandelion is rich in vitamins and trace elements, which can nourish skin of all types. It also contains taraxerol, taraxacin, choline, organic acids, inulin and other components, which have significant inhibitory effects on Staphylococcus aureus, hemolytic streptococci and pneumococci.

[0021] Catnip (Nepeta cataria) primarily exhibits strong antibacterial activity against Staphylococcus aureus and Corynebacterium diphtheriae. Furthermore, it shows some inhibitory effects against Bacillus anthracis, Streptococcus pyogenes, Salmonella typhi, Shigella dysenteriae, Pseudomonas aeruginosa, and Mycobacterium tuberculosis. The volatile oils in catnip are mainly menthone, flavonoids, and furans, and it also contains various trace elements. These components strongly promote blood circulation in the skin, enhance sweat gland secretion, and facilitate the destruction and absorption of diseased tissues. In addition, modern pharmacological studies have demonstrated that catnip possesses anti-allergic properties and can be used to treat allergic dermatitis.

[0022] The active ingredients of Salvia miltiorrhiza are mainly divided into two categories: fat-soluble and water-soluble. Regarding fat-soluble compounds, more than 40 compounds have been identified, which can be further divided into two classes: tanshinones and roshinones. Most tanshinone compounds belong to the diterpenoid family, such as tanshinone I, tanshinone II-A, tanshinone II-B, tanshinone III, isotanshinone, isocryptantanshinone, hydroxytanshinone II-A, and dihydrotanshinone I. The water-soluble components of Salvia miltiorrhiza all possess phenolic acid structures. The earliest discovered phenolic acid compound was tanshinone, followed by a series of phenolic acid compounds including tanshinone A, B, C, D, E, F, H, I, J, tetramethyltanshinone C, as well as rosmarinic acid and lithospermic acid. Both fat-soluble and water-soluble components of tanshinone are effective components. Fat-soluble tanshinone mainly improves blood circulation, has antibacterial and anti-inflammatory effects, while water-soluble tanshinone has significant antioxidant, anticoagulant, antithrombotic, lipid-regulating and cell-protective effects.

[0023] Rhubarb is primarily composed of anthraquinone derivatives, including anthraquinone glycosides and bianthraquinone glycosides. Bianthraquinone glycosides include sennosides A, B, C, D, E, and F; free aglycones include rhein, emodin, chrysophanol, aloe-emodin, and emodin methyl ether, as well as tannins, organic acids, and estrogen-like substances. It has inhibitory effects on various bacteria, with Staphylococcus and Streptococcus being the most sensitive. Rhubarb also possesses antiviral, antitumor, and oxygen free radical scavenging effects, and can improve local microcirculation and regulate coagulation and bleeding.

[0024] Licorice contains abundant glycyrrhizic acid, glycyrrhizin and other components, which have the effects of regulating skin immune function, scavenging oxygen free radicals, anti-aging, anti-inflammatory, anti-allergic reaction and nourishing the skin.

[0025] This invention is a pure traditional Chinese medicine preparation, composed according to traditional Chinese medicine theory. Clove is the principal ingredient, acting as a warming and softening agent, and promoting aromatic penetration. Silkworm pupae are also a principal ingredient, acting as a skin tonic, moisturizing agent, and to remove dark spots and blemishes. Aconitum carmichaelii is an assistant ingredient, acting as a wind-dispelling agent, promoting the flow of the medicine, moisturizing the skin, removing scars, and whitening the skin. Dandelion is an assistant ingredient, acting as a cleansing and skin-strengthening agent, regulating skin function, and delaying aging. Peach kernel is an assistant ingredient, acting as a blood-activating agent, removing blood stasis, softening scars, moisturizing the skin, removing wrinkles, and whitening the skin. Salvia miltiorrhiza is an assistant ingredient, acting as a blood-activating agent, removing blood stasis, inhibiting bacteria, and promoting wound healing. Schizonepeta tenuifolia is an adjuvant ingredient, acting as a skin cleanser, promoting skin penetration, dispelling wind, and whitening the skin. Rhubarb is an adjuvant ingredient, acting as a purgative, purging agent, relieving pain, and eliminating scars. Chrysanthemum morifolium is an adjuvant ingredient, acting as an oil-removing agent, inhibiting bacteria, suppressing dark spots, and removing wrinkles. Gleditsia sinensis is an adjuvant ingredient, acting as a meridian-clearing agent, removing dirt, moisturizing the skin, and promoting absorption. Licorice is the guiding ingredient, acting as a skin-moisturizing agent, whitening agent, removing blemishes and deodorizing agent, and harmonizing the effects of the other ingredients.

[0026] This invention can significantly improve superficial and hypertrophic scars within one month, softening scar tissue, promoting epithelialization of scar tissue and normalizing the secretion of skin glands, dissipating local melanocyte aggregation, and increasing skin luster and elasticity. Attached Figure Description

[0027] Figure 1 Results of 28-day treatment for facial scars in a 56-year-old female patient;

[0028] Figure 2 Results of treating facial, neck, and chest scars in a 38-year-old male patient after 10 days;

[0029] Figure 3 Results of treating leg scars in a 1-year-old male patient after 18 days. Detailed Implementation

[0030] The present invention will be further described below, with each portion being 10 grams:

[0031] Example 1

[0032] 10 parts white chrysanthemum, 8 parts silkworm, 20 parts clove, 4 parts peach kernel, 3 parts soapberry, 20 parts dandelion, 6 parts schizonepeta, 8 parts salvia miltiorrhiza, 3 parts rhubarb, and 6 parts licorice.

[0033] The above-mentioned Chinese herbal medicine components are prepared into powder, and the preparation method is as follows:

[0034] After mixing the Chinese herbal medicine components, grind them into powder using an ultrafine grinder, pass them through a 120-mesh sieve three times, sterilize them by irradiation with cobalt-60, and then package them for later use.

[0035] Example 2

[0036] White chrysanthemum 15 parts, silkworm 12 parts, clove 30 parts, peach kernel 8 parts, soap pod 5 parts, dandelion 40 parts, schizonepeta 8 parts, salvia miltiorrhiza 12 parts, rhubarb 5 parts, licorice 10 parts.

[0037] The above-mentioned Chinese herbal medicine components are formulated into an essence, and the preparation method is as follows:

[0038] After mixing the Chinese herbal medicine components, the main essence of the prescription is extracted by pressing and percolation, sterilized by cobalt-60 irradiation, and then packaged for later use.

[0039] Example 3

[0040] White chrysanthemum 12 parts, silkworm 10 parts, clove 25 parts, peach kernel 6 parts, soapberry 4 parts, dandelion 30 parts, schizonepeta 7 parts, salvia miltiorrhiza 10 parts, rhubarb 4 parts, licorice 8 parts.

[0041] The above-mentioned Chinese herbal ingredients are prepared into an ointment, and the preparation method is as follows:

[0042] After mixing the Chinese herbal medicine components, add purified water and boil. Extract the distillate by distillation, add honey to the distillate and continue boiling to form a paste. Sterilize with cobalt-60 irradiation and then package for later use.

[0043] Comparative Example 1

[0044] Replace white chrysanthemum with angelica dahurica, and make it from the following Chinese herbs in parts by weight: 12 parts angelica dahurica, 10 parts silkworm pupa, 25 parts clove, 6 parts peach kernel, 4 parts soapberry, 30 parts dandelion, 7 parts schizonepeta tenuifolia, 10 parts salvia miltiorrhiza, 4 parts rhubarb, and 8 parts licorice.

[0045] The above-mentioned Chinese herbal medicine components were prepared into powder, and the preparation method was the same as in Example 1.

[0046] Comparative Example 2

[0047] Replace the soapberry with white aconite, and make it from the following Chinese medicines in parts by weight: white chrysanthemum 12 parts, silkworm 10 parts, clove 25 parts, peach kernel 6 parts, white aconite 4 parts, dandelion 30 parts, schizonepeta 7 parts, salvia miltiorrhiza 10 parts, rhubarb 4 parts, and licorice 8 parts.

[0048] The above-mentioned Chinese herbal medicine components were made into an essence, and the preparation method was the same as in Example 2.

[0049] Comparative Example 3

[0050] The proportions of the Chinese herbal medicine components were changed, and the medicine was made from the following parts by weight: 6 parts white chrysanthemum, 8 parts silkworm, 20 parts clove, 4 parts peach kernel, 5 parts white aconite, 20 parts dandelion, 5 parts schizonepeta, 8 parts salvia miltiorrhiza, 3 parts rhubarb, and 6 parts licorice.

[0051] The above-mentioned Chinese herbal ingredients were made into an ointment, and the preparation method was the same as in Example 3.

[0052] Example 4

[0053] The following are typical cases during treatment:

[0054] Case 1:

[0055] Patient Li, female, 56 years old, had hypertrophic scars covering approximately 70% of her face due to burns. After admission, she was treated with the traditional Chinese medicine powder described in Example 1. The powder was mixed with water to form a paste and applied topically to the affected area three times a day. Before use, the scars were noticeably red and hypertrophic. After 14 days of use, the redness of the facial scars significantly faded, and the hypertrophic scars began to shrink. After 28 days of use, most of the scars had returned to their original skin color; some scars remained red, but the hypertrophic scars were almost invisible. One month after stopping the medication, the facial scars were completely healed. The treatment effect is as follows: Figure 1 As shown: a is before treatment; b is after 14 days of treatment; c is after 28 days of treatment; d is after 1 month of stopping medication.

[0056] Case 2:

[0057] Patient Li, male, 38 years old, presented with burn scars on his face, neck, and chest. His face and neck had red scars, while his chest had both red and hypertrophic scars. After consultation, he was treated with the essence described in Example 2, applied three times a day to his face, neck, and chest. After 10 days of use, the red scars on his face and neck completely faded, the redness of the chest scars subsided, and the hypertrophic nodules shrank and softened. The treatment effect was as follows: Figure 2 As shown: a is left before treatment; b is frontal before treatment; c is right before treatment; d is left 10 days after treatment; e is frontal 10 days after treatment; f is right 10 days after treatment.

[0058] Case 3:

[0059] Patient Zhang, male, 1 year old, had scars on his thighs and calves caused by burns. After admission, he was treated with the traditional Chinese medicine ointment described in Example 3, applied to the scars three times a day. After 10 days of use, the red scars on his legs noticeably lightened in color; after 18 days, most of the red scars had returned to their natural skin color, with only a small portion remaining unremoved. The treatment effect was as follows. Figure 3 As shown: a is before treatment; b is after 10 days of treatment; c is after 18 days of treatment.

[0060] Example 5: Statistical Study of Drug Efficacy

[0061] 1. Cases: A total of 224 patients with scars were treated, including 132 cases of superficial scars and 92 cases of hypertrophic scars; the patients' ages ranged from 1 to 72 years; there were 126 males and 98 females.

[0062] 2. Treatment method: Apply the medicine made from traditional Chinese medicine in Examples 1-3, Comparative Examples 1-3 and Patent CN106214974 A to the scar three times a day. One course of treatment is 7 days. A total of 2-5 courses of treatment are required.

[0063] 3. Criteria for determining the effectiveness of scar treatment:

[0064] After healing, the color and thickness of the scar tissue are basically the same as the surrounding skin. The scar tissue is soft to the touch and has good mobility.

[0065] Effective; the color of the scar tissue lightened compared to before use, the difference in thickness was greater than 0.1cm, and the hardness of the scar tissue decreased.

[0066] Ineffective; the color of the scar tissue did not improve or even worsened, and there was no improvement in thickness or hardness.

[0067] Table 1. Comparison of the therapeutic effects of seven traditional Chinese medicine ingredients on scars.

[0068]

[0069] The clinical treatment efficacy statistics are shown in Table 1. In Examples 1-3, the traditional Chinese medicine preparations achieved an efficacy rate of over 88% for superficial scars and over 83% for hypertrophic scars. When Angelica dahurica replaced Chrysanthemum morifolium, or Aconitum carmichaelii replaced Gleditsia sinensis, or when the composition ratio was changed, the efficacy rates for both superficial and hypertrophic scars significantly decreased. The preparation prepared under patent publication number CN106214974 A achieved an efficacy rate of 77% for superficial scars, but only 23.5% for hypertrophic scars. Therefore, this invention has significant effects on the treatment of both superficial and hypertrophic scars, softening scar tissue, promoting epithelialization of scar tissue and normalizing the secretion of skin glands, dissipating local melanocyte aggregation, and increasing skin luster and elasticity.

[0070] The above embodiments are merely illustrative of the concept and implementation of the present invention and are not intended to limit it. Under the concept of the present invention, technical solutions without substantial changes are still within the scope of protection.

Claims

1. A traditional Chinese medicine for treating scar, characterized in that, The raw materials are prepared by weight parts as follows: white chrysanthemum 10-15 parts, silkworm 8-12 parts, clove 20-30 parts, peach kernel 4-8 parts, soap 3-5 parts, dandelion 20-40 parts, catmint 6-8 parts, salvia 8-12 parts, rhubarb 3-5 parts, and licorice 6-10 parts.

2. The traditional Chinese medicine according to claim 1, characterized in that, The raw materials are prepared by weight parts as follows: white chrysanthemum 10-15 parts, silkworm 8-12 parts, clove 20-30 parts, peach kernel 4-8 parts, soap 3-5 parts, dandelion 20-40 parts, catmint 6-8 parts, salvia 8-12 parts, rhubarb 3-5 parts, and licorice 6-10 parts.

3. The traditional Chinese medicine according to claim 1 or 2, characterized in that, The dosage form of the traditional Chinese medicine is one of powder, solution, ointment or essence.

4. The traditional Chinese medicine according to claim 3, characterized in that, The preparation method of the powder is as follows: the raw materials of traditional Chinese medicine are mixed, and then grinded into powder by a superfine grinder, and then passed through a 120-mesh sieve for 3 times, and then sterilized by Co60 and packaged.

5. The traditional Chinese medicine as described in claim 3, characterized in that, The preparation method of the solution is as follows: the raw materials of traditional Chinese medicine are mixed, and then boiled by adding pure water, and then distilled to obtain a distilled liquid, and then sterilized by Co60 and packaged.

6. The traditional Chinese medicine according to claim 3, wherein, The preparation method of the ointment is as follows: the raw materials of traditional Chinese medicine are mixed, and then boiled by adding pure water, and then distilled to obtain a distilled liquid, and then boiled by adding honey to obtain an ointment, and then sterilized by Co60 and packaged.

7. The traditional Chinese medicine as described in claim 3, characterized in that, The preparation method of the essence is as follows: the raw materials of traditional Chinese medicine are mixed, and then extracted by a pressing and percolation method to obtain the main essence of the prescription, and then sterilized by Co60 and packaged.

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