A Chinese medicine composition for treating motion sickness and preparation method thereof

Abstract

The present invention provides a traditional Chinese medicine composition for treating motion sickness and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition for treating motion sickness provided by the present invention comprises the following components in parts by weight: 20-50 parts of lemon, 20-50 parts of forsythia, 10-30 parts of wild chrysanthemum, 3-7 parts of fennel, 5-10 parts of sandalwood, 5-10 parts of bark lotus, 10-20 parts of dried tangerine peel, 2-5 parts of evodia rutaecarpa, 5-10 parts of patchouli, 15-30 parts of borneol, and 15-30 parts of mint. The present invention achieves the effects of refreshing the mind, stopping vomiting, and enhancing appetite through the synergistic cooperation of the various components. While improving the slow onset and side effects of traditional motion sickness treatment drugs, it has a good effect in preventing and treating motion sickness, and the product has good stability.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating motion sickness and a preparation method thereof. Background Art

[0002] In a rapidly developing economy and rapidly evolving transportation, the incidence of motion sickness has increased significantly. Motion sickness, also known as motion sickness, is a condition characterized by a series of vestibular and autonomic reactions, including dizziness, vertigo, nausea, vomiting, pale complexion, and loss of appetite, caused by an inability to adapt to acceleration, visual, and deep sensory stimulation. These symptoms cause significant distress and can even severely impact people's ability to travel and work.

[0003] Most anti-sickness medications currently on the market are taken orally and must be taken before motion sickness develops. Taking them after symptoms of motion sickness develops is ineffective, and oral medications are slow to take effect, leading to side effects such as drowsiness and sleepiness. Certain occupational groups require constant optimal physical condition, and the onset of motion sickness can severely impact their reaction speed and physical performance. Even after oral administration of motion sickness-suppressing medications, their side effects can significantly hinder optimal function. Therefore, it is crucial to provide a fast-acting, side-free, and oral medication for the treatment of motion sickness in these occupational groups. Summary of the Invention

[0004] In view of this, the object of the present invention is to provide a Chinese medicine composition for treating motion sickness and a preparation method thereof. Through a reasonable formulation, while changing the administration method of traditional drugs for treating motion sickness, it can achieve a rapid onset of action, is easy to use, and has a good effect in preventing and treating motion sickness.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] The invention provides a traditional Chinese medicine composition for treating motion sickness. The composition comprises the following components in parts by weight: 20-50 parts of lemon, 20-50 parts of forsythia, 10-30 parts of wild chrysanthemum, 3-7 parts of fennel, 5-10 parts of sandalwood, 5-10 parts of bark scutellaria, 10-20 parts of tangerine peel, 2-5 parts of evodia rutaecarpa, 5-10 parts of patchouli, 15-30 parts of borneol, and 15-30 parts of mint.

[0007] Preferably, the composition comprises the following components in parts by weight: 25-40 parts of lemon, 25-40 parts of forsythia, 15-25 parts of wild chrysanthemum, 4-6 parts of fennel, 7-9 parts of sandalwood, 7-9 parts of bark scutellaria, 12-18 parts of tangerine peel, 3-4.5 parts of evodia rutaecarpa, 7-9 parts of patchouli, 18-25 parts of borneol, and 18-25 parts of mint.

[0008] Preferably, the composition comprises the following components in parts by weight: 30 parts of lemon, 30 parts of forsythia, 20 parts of wild chrysanthemum, 5 parts of fennel, 8 parts of sandalwood, 8 parts of bark scutellaria, 15 parts of tangerine peel, 4 parts of evodia rutaecarpa, 8 parts of patchouli, 20 parts of borneol, and 20 parts of mint.

[0009] The present invention also provides a method for preparing the Chinese medicine composition, comprising the following steps:

[0010] (1) Soaking Scutellaria barbata and Evodia rutaecarpa, then mixing with lemon, forsythia, wild chrysanthemum, fennel, sandalwood, tangerine peel, patchouli, and mint, and boiling for 1 to 3 times, combining the decoctions, filtering, and concentrating the filtrate to obtain a concentrated solution;

[0011] (2) Mixing borneol with the concentrated solution to obtain a composition.

[0012] Preferably, the soaking time is 10 to 30 minutes.

[0013] Preferably, the decoction time is 15 to 40 minutes per time, and the decoction temperature is 90 to 100°C.

[0014] Preferably, the concentration is reduced-pressure concentration, the concentration temperature is 35-55° C., and the volume after concentration is 2 / 5-3 / 5 of the original volume.

[0015] Preferably, the composition is in the form of a spray.

[0016] Compared with the prior art, the present invention has the following beneficial effects: the present invention provides a traditional Chinese medicine composition for treating motion sickness and a preparation method thereof, wherein lemon having the effects of promoting body fluid, quenching thirst and dispelling summer heat, forsythia having the effects of clearing away heat and toxic substances, reducing swelling and dispersing stagnation and dispersing wind-heat, wild chrysanthemum having the effects of clearing away heat and toxic substances, purging fire and calming the liver, fennel having the effects of dispelling cold and relieving pain, regulating qi and harmonizing the stomach, sandalwood having the effects of promoting qi and warming the middle, stimulating appetite and relieving pain, Scutellaria barbata having the effects of clearing heat and toxic substances, removing blood stasis and promoting diuresis, tangerine peel having the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm, evodia rutaecarpa having the effects of dispelling cold and relieving pain, relieving adverse reactions and vomiting, and promoting yang and relieving diarrhea, patchouli having the effects of aromatically clearing turbidity, harmonizing the middle and stopping vomiting, and relieving summer heat, mint having the effects of dispersing wind-heat, clearing the head and eyes, relieving sore throat, clearing rashes, and soothing the liver and promoting qi, and borneol having the effects of invigorating the mind, clearing away heat and relieving pain. The components work together to achieve the effects of refreshing the mind, stopping vomiting, and increasing appetite. While improving the slow onset and side effects of traditional motion sickness treatment drugs, this product has a good effect in preventing and treating motion sickness, and this product has good stability. DETAILED DESCRIPTION

[0017] The present invention provides a traditional Chinese medicine composition for treating motion sickness, comprising the following components in parts by weight:

[0018] 20-50 parts of lemons, preferably 25-40 parts, more preferably 30 parts;

[0019] 20-50 parts of Forsythia suspensa, preferably 25-40 parts, more preferably 30 parts;

[0020] 10-30 parts of wild chrysanthemum, preferably 15-25 parts, more preferably 20 parts;

[0021] 3 to 7 parts of fennel, preferably 4 to 6 parts, more preferably 5 parts;

[0022] 5-10 parts of sandalwood, preferably 7-9 parts, more preferably 8 parts;

[0023] 5-10 parts of Scutellaria barbata, preferably 7-9 parts, more preferably 8 parts;

[0024] 10-20 parts of dried tangerine peel, preferably 12-18 parts, more preferably 15 parts;

[0025] 2-5 parts of Evodia rutaecarpa, preferably 3-4.5 parts, more preferably 4 parts;

[0026] 5-10 parts of patchouli, preferably 7-9 parts, more preferably 8 parts;

[0027] 15-30 parts of borneol, preferably 18-25 parts, more preferably 20 parts;

[0028] 15 to 30 parts of mint, preferably 18 to 25 parts, more preferably 20 parts.

[0029] In the present invention, lemon has a sour and sweet taste, a neutral nature, enters the liver and stomach meridians, and has the effects of resolving phlegm and relieving cough, promoting the production of body fluids, and strengthening the spleen.

[0030] Forsythia suspensa has a bitter and slightly cold nature. It enters the lung, heart, and small intestine meridians. It has the effects of clearing heat and detoxifying, reducing swelling and dispersing stagnation, and dispersing wind-heat.

[0031] Wild chrysanthemum is bitter, pungent, and slightly cold in nature. It enters the Liver and Heart meridians. It clears away heat, detoxifies, and calms the liver.

[0032] Fennel is pungent and warm in nature. It enters the liver, kidney, spleen, and stomach meridians. It has the effects of strengthening the stomach and regulating qi, killing bacteria, and dispelling cold and relieving pain.

[0033] Sandalwood is pungent and warm in nature. It enters the spleen, stomach, heart, and lung meridians. It has the effects of promoting qi and warming the middle, stimulating appetite and relieving pain.

[0034] Scutellaria barbata has pungent, bitter, and cold properties. It enters the lung, liver, and kidney meridians. It has the effects of clearing heat and detoxifying, removing blood stasis, and promoting diuresis.

[0035] Tangerine peel has bitter, pungent, and warm properties. It enters the lung and spleen meridians. It has the effects of regulating qi and strengthening the spleen, and clearing dampness and resolving phlegm.

[0036] Evodia rutaecarpa has pungent, bitter, and warm properties. It enters the liver, spleen, stomach, and kidney meridians. It has the effects of dispelling cold and relieving pain, relieving adverse reactions and vomiting, and boosting yang and stopping diarrhea.

[0037] Patchouli has a pungent and slightly warm nature. It enters the spleen, stomach, and lung meridians. It has aromatic properties that clear turbidity, soothe the stomach and stop vomiting, and relieve heat.

[0038] Borneol is pungent, bitter, and slightly cold in nature. It enters the heart, spleen, and lung meridians. It has the effects of invigorating the mind, clearing away heat, and relieving pain.

[0039] Peppermint has a pungent and cooling nature. It enters the lung and liver meridians. It has the effects of dispersing wind-heat, clearing the head and eyes, relieving sore throats, clearing rashes, and soothing the liver and promoting qi.

[0040] The present invention also provides a method for preparing the Chinese medicine composition, comprising the following steps:

[0041] (1) Soaking Scutellaria barbata and Evodia rutaecarpa, then mixing with lemon, forsythia, wild chrysanthemum, fennel, sandalwood, tangerine peel, patchouli, and mint, and boiling for 1 to 3 times, combining the decoctions, filtering, and concentrating the filtrate to obtain a concentrated solution;

[0042] (2) Mixing borneol with the concentrated solution to obtain a composition.

[0043] In the present invention, after soaking Scutellaria barbata and Evodia rutaecarpa, they are mixed with lemon, forsythia, wild chrysanthemum, fennel, sandalwood, tangerine peel, patchouli, and mint and decocted for 1 to 3 times. The decoctions are combined, filtered, and the filtrate is concentrated to obtain a concentrated solution. The present invention has no particular limitation on the source of the raw materials, and conventional commercially available products can be used. The present invention comprises soaking the barbata scutellaria and evodia rutaecarpa in water, wherein the amount of water is 4 to 6 times the total mass of the barbata scutellaria, evodia rutaecarpa, lemon, forsythia, wild chrysanthemum, fennel, sandalwood, tangerine peel, patchouli and mint; the soaking time is 10 to 30 minutes, preferably 15 to 25 minutes, and more preferably 20 minutes; the mixing comprises directly adding the lemon, forsythia, wild chrysanthemum, fennel, sandalwood, tangerine peel, patchouli and mint into the water in which the barbata scutellaria and evodia rutaecarpa are soaked; the decoction time is 15 to 40 minutes per time, preferably 20 to 35 minutes per time, and more preferably 30 minutes per time; the decoction temperature is 90 to 100° C., preferably 92 to 98° C., and further The step is preferably 95°C; the filtration first uses 4 to 5 layers of gauze to separate the solid and liquid, and then the separated liquid is filtered again by centrifugation, and the supernatant is taken as the filtrate, the centrifugal speed is 2000 to 5000 rpm, preferably 2500 to 4500 rpm, and more preferably 3000 rpm; the centrifugation time is 5 to 15 min, preferably 7 to 12 min, and more preferably 10 min; the concentration is reduced pressure concentration, and the concentration temperature is 35 to 55°C, preferably 40 to 50°C, and more preferably 45°C; the volume after concentration is 2 / 5 to 3 / 5 of the original volume, preferably 9 / 20 to 11 / 20, and more preferably 1 / 2.

[0044] In the present invention, borneol is mixed with the concentrated solution to obtain a composition. The mixing method is not particularly limited and can be performed using conventional methods. The composition is in the form of a spray.

[0045] The technical solutions provided by the present invention are described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0046] Example 1

[0047] Take lemon 300g, Fructus Forsythiae 300g, Flos Chrysanthemi Indici 200g, Fructus Cuminoides 50g, Ligusticum santaliensis 80g, Scutellaria barbata 80g, Pericarpium Citri Reticulatae 150g, Fructus Evodiae 40g, Herba Patchouli 80g, Borneolum Syntheticum 200g, Herba Menthae 200g, standby.Use pulverizer to pulverize respectively Fructus Chrysanthemi Indici, Ligusticum santaliensis, Herba Menthae, cross 10 mesh sieves, collect undersize component.After Scutellaria barbata, Fructus Evodiae 20min are soaked in the water of 7.4kg, add lemon, Fructus Forsythiae, Fructus Cuminoides, Pericarpium Citri Reticulatae, Herba Patchouli and the pulverized Fructus Chrysanthemi Indici, Ligusticum santaliensis, Herba Menthae, high fire boils, low fire boils 30min, obtains first time decoction.Adopt 4 layers of gauze that medicinal residues and decoction are carried out solid-liquid separation, in the medicinal residues of separation, again put into 7.4kg water, high fire boils, low fire boils 30min, adopts same mode that medicinal residues are separated from decoction, obtains second time decoction. The two decoctions were combined and filtered again by centrifugation. The speed of the centrifuge was set to 3000 rpm for 10 minutes to obtain a filtrate. The filtrate was placed in a vacuum concentration device and the temperature was set to 45° C. for concentration to 1 / 2 of the original filtrate volume to obtain a concentrated solution. 200 g of borneol was added to the concentrated solution and mixed evenly. The solution was sterilized and filtered and then divided into spray bottles to obtain a spray for treating motion sickness.

[0048] Example 2

[0049] Take lemon 200g, Fructus Forsythiae 200g, Flos Chrysanthemi Indici 100g, Fructus Cuminoides 30g, Alpinia Santali 50g, Scutellaria Barbatae 50g, Pericarpium Citri Reticulatae 100g, Fructus Evodiae 20g, Herba Patchouli 50g, Borneolum Syntheticum 150g, Herba Menthae 150g, standby.Use pulverizer to pulverize respectively Fructus Chrysanthemi Indici, Alpinia Santali, Herba Menthae, cross 10 mesh sieves, collect undersize component.After Scutellaria Barbatae, Fructus Evodiae 100min are soaked in the water of 4.4kg, add Fructus Chrysanthemi Indici, Fructus Forsythiae, Fructus Cuminoides, Fructus Patchouli and the pulverized Fructus Chrysanthemi, Alpinia Santali, Herba Menthae, high fire boils, low fire boils 15min, obtains first time decoction.Adopt 4 layers of gauze that medicinal residues and decoction are carried out solid-liquid separation, in the medicinal residues of separation, again put into 4.4kg water, high fire boils, low fire boils 15min, adopts same mode that medicinal residues are separated from decoction, obtains second time decoction. The two decoctions were combined and filtered again by centrifugation. The speed of the centrifuge was set to 2000 rpm for 15 minutes to obtain a filtrate. The filtrate was placed in a vacuum concentration device and the temperature was set to 40° C. for concentration. The filtrate was concentrated to 2 / 5 of the volume of the original filtrate to obtain a concentrated solution. 150 g of borneol was added to the concentrated solution and mixed evenly. The solution was sterilized and filtered and then divided into spray bottles to obtain a spray for treating motion sickness.

[0050] Example 3

[0051] Take lemon 500g, Fructus Forsythiae 500g, Flos Chrysanthemi Indici 300g, Fructus Cuminoides 70g, Alpinia Santali 100g, Scutellaria Barbatae 100g, Pericarpium Citri Reticulatae 200g, Fructus Evodiae 50g, Herba Patchouli 100g, Borneolum Syntheticum 300g, Menthol 300g, standby.Use pulverizer to pulverize respectively Fructus Chrysanthemi Indici, Fructus Santali, Herba Patchouli, 300g, Menthol 300g.After Scutellaria Barbatae, Fructus Evodiae are soaked 30min in the water of 15.1kg, add Fructus Chrysanthemi Indici, Fructus Cuminoides, Pericarpium Citri Reticulatae, Herba Patchouli and the pulverized Fructus Chrysanthemi, Alpinia Santali, Menthol, high fire boils, and low fire decocts 40min, obtains first time decoction. The residue and the decoction were separated using five layers of gauze. 15.1 kg of water was again added to the separated residue, brought to a boil over high heat, and decocted over low heat for 40 minutes. The residue and the decoction were separated in the same manner to obtain a second decoction. The two decoctions were combined and filtered again by centrifugation at a speed of 5000 rpm for 5 minutes to obtain a filtrate. The filtrate was placed in a vacuum concentrator at a temperature of 55° C. and concentrated to 3 / 5 of the original filtrate volume to obtain a concentrate. 300 g of borneol was added to the concentrate, mixed uniformly, and sterilized and filtered before being dispensed into spray bottles to obtain a spray for treating motion sickness.

[0052] Experimental Example 1

[0053] The motion sickness treatment spray prepared by the method of Example 1 was used as a medicine. White Chinese rabbits in good physical condition were selected, half male and half female, weighing 1.5-2.5 kg. After one week of adaptive feeding, they were randomly divided into 4 groups, 10 in each group, namely high-dose, medium-dose, and low-dose groups of the motion sickness treatment spray and a blank control group. The high-dose group was sprayed with 10 mL of the medicine each time, the medium-dose group was sprayed with 5 mL of the medicine each time, the low-dose group was sprayed with 1 mL of the medicine each time, and the blank control group was sprayed with 1 mL of normal saline each time. 24 h before administration, the hair on the back of the rabbits was shaved with electric clippers, and then 8% sodium sulfate was used for hair removal, and the hair removal area was about 100 cm 2 Before administration, check whether the skin is damaged. If damaged, do not use it. Spray the agent or normal saline evenly on the hairless skin of the rabbit. Administer the drug three times a day for four consecutive weeks. During the test, use an electric shear to remove hair from the rabbit at irregular intervals according to the recovery of the fur. Eat and drink freely before and after administration. Observe the administration site daily for erythema or swelling, and observe the animal's behavior, diet, response to stimulation, secretions, excretions, etc., and record the animal's toxic reactions, including poisoning symptoms, onset time, severity, duration, and death. If abnormalities are found, perform a histopathological examination.

[0054] No animal deaths occurred within four weeks of continuous dosing, and no redness, erythema, or swelling was observed on the skin of any of the animals, indicating that this product does not cause allergic reactions in animals. After administration, the rabbits' behavior, mental state, and bowel movements were normal, and their growth and development were good. Their diet increased compared to the normal group, and their weight gain was higher than that of the control group. This is attributed to the presence of borneol and mint in the drug, which promote drug absorption, and the presence of lemon, fennel, and sandalwood in the spray, which stimulate the appetite and strengthen the spleen. Therefore, spraying the drug stimulates the rabbits' feeding, leading to weight gain. Aside from food intake and weight gain, no other significant behavioral changes or signs of toxicity were observed in the rabbits, indicating that this product has no toxic side effects on animals.

[0055] Table 1 Effects of motion sickness spray on rabbit body weight ( n=10, kg)

[0056] time Blank control High-dose group Medium dose group Low-dose group Before administration 2.02±0.16 2.01±0.11 2.02±0.14 2.00±0.17 1 week of medication 2.09±0.20 2.39±0.14 2.31±0.19 2.12±0.20 2 weeks of medication 2.12±0.10 2.57±0.22 2.44±0.13 2.19±0.18 3 weeks of medication 2.15±0.15 2.71±0.18 2.53±0.21 2.25±0.12 4 weeks of medication 2.22±0.18 2.83±0.20 2.61±0.22 2.30±0.11

[0057] Experimental Example 2

[0058] SPF mice (half male and half female, weighing 18-22g) in good health were selected. After three days of acclimatization, they were randomly divided into five groups, each with 10 mice: a normal group, a model group (normal saline), a positive control group 1 (scopolamine), a positive control group 2 (Baihu Fengyoujing mint spray), and a motion sickness spray group. Thirty minutes before the experiment, mice were treated with 1 mL / 100g of the drug by gavage in the positive control group 1, and 0.2 mL / application of the drug in the model, positive control 2, and motion sickness spray groups.

[0059] Modeling method: Except for the normal group, the mice in other groups were placed without restraint in a homemade rotator imitated from the study of Crampton GH et al. (Crampton GH LJ. A stimulator for laboratory studies of motion sickness incats. Aviat Space Environ Med 1985; 56: 462-5.) at a speed of about 400 r / min and rotated horizontally for 5 minutes.

[0060] After modeling, mice were immediately transferred to an open-field box. The time it took for the abdomen and tail to leave the ground was recorded. If the mice did not fully recover within 30 minutes, they were considered unrecovered. Motion sickness symptom scoring was performed during the open-field behavioral experiment. The scoring criteria are shown in Table 2.

[0061] Table 2 Motion sickness symptom scoring table

[0062]

[0063] Table 3 Results of field experiments ( n=10, min)

[0064] Group Abdomen off the ground time Tail off the ground time Normal group 0 0 Model Group 16.89±3.32 14.92±2.64 Positive control group 1 10.53±2.01 8.82±1.50 Positive control group 2 11.04±1.43 9.17±1.72 Motion sickness spray group 7.14±1.07 5.16±1.35

[0065] Table 4 Results of motion sickness scoring in mice (X±s, n=10, points)

[0066] Group Total score of dizziness reaction index Normal group 0 Model Group 5.88±1.11 Positive control group 1 4.67±0.92 Positive control group 2 4.43±0.78 Motion sickness spray group 3.32±0.85

[0067] As shown in Tables 3 and 4, the positive control group and the motion sickness spray group showed significantly shorter limb recovery times and tail lift-off times compared to the model group. The motion sickness spray significantly reduced recovery time compared to the positive control group. The lower the motion sickness index, the better the effect. Therefore, the motion sickness spray significantly reduced the motion sickness index, demonstrating that it is more effective than commercially available medications for treating motion sickness.

[0068] Experimental Example 3

[0069] Experimental drug: The spray prepared in Example 1 of the present invention was used.

[0070] Experimental subjects: The experimenters were combat personnel with good physical fitness, a total of 120 people, all of whom experienced varying degrees of motion sickness after long-term combat at sea. Among them, 15 people suffered from severe motion sickness, with symptoms such as severe nausea, vomiting, loss of appetite, mental fatigue, and even loss of combat capability during combat at sea; 34 people suffered from moderate motion sickness, with symptoms such as dizziness, nausea, loss of appetite, and decreased combat effectiveness; and 71 people suffered from mild motion sickness, with symptoms such as mild dizziness and loss of appetite. The subjects were divided into an experimental group of 100 people and a control group of 20 people. The experimental group used the spray prepared in Example 1 of the present invention, and the control group used the commercially available scopolamine tablets.

[0071] Directions:

[0072] Experimental group: Patients with different degrees of motion sickness were randomly divided into two groups. Group A sprayed the spray on the temples or behind the ears before boarding the ship and then sprayed it every four hours, with each spraying dosage of 2 pumps (about 0.4mL). Group B sprayed the spray on the temples or behind the ears after the onset of motion sickness symptoms on board the ship. The time for the symptoms to be alleviated and eliminated, as well as the time for the motion sickness symptoms to reappear, were recorded.

[0073] Control group: Scopolamine tablets were taken according to the instructions of the product.

[0074] Table 5 Effect of treating motion sickness

[0075]

[0076]

[0077] As can be seen from Table 5, using the spray of the present invention, a total of 95 cases, accounting for 95%, had their symptoms relieved; a total of 4 cases, accounting for 4%; a total of 1 case, accounting for 1%, had no effect, and the total effective rate was 99%. Although the results of this experiment show that the effect of the product used in the present invention is slightly higher than that of the existing commercially available product, the reason may be that there are fewer people in the comparative example using the commercially available product in this application. Therefore, it can be determined that the effect in this application is the same as that of the existing product.

[0078] Table 6 Onset time and time of recurrence of motion sickness

[0079]

[0080] As shown in Table 6, the sprays of the present invention can all take effect within 30 minutes and can last up to 8 hours, indicating that the products obtained in this application have the characteristics of rapid onset, ease of use, and long effective duration. Through observation of the experimenters, it was found that the people who used the spray of this application to treat motion sickness did not experience drowsiness, drink a lot of water, etc., and did not experience loss of appetite, while the people who used scopolamine tablets all experienced drowsiness or drink a lot of water. This shows that although the use of this product may result in 1% ineffectiveness, it can solve the loss of appetite caused by motion sickness and does not produce other side effects, indicating that the spray obtained in this invention is very suitable for use by certain special occupational groups.

[0081] Experimental Example 4

[0082] The spray obtained in Example 1 was placed in an environment with a temperature of 30°C ± 2°C and a relative humidity of 65% ± 5% for 12 months, and samples were taken every 3 months. The effects were tested at 0 months, 3 months, 6 months, 9 months, and 12 months.

[0083] Table 7 Motion sickness score results of mice at different sampling times (X±s, n=10, points)

[0084] time Total score of dizziness reaction index 0 months 3.32±0.85 3 months 3.31±0.52 6 months 3.31±0.84 9 months 3.32±0.66 12 months 3.30±0.71

[0085] As shown in Table 7, although there are slight differences in the motion sickness scores of mice for samples taken at different times, the differences are not obvious, which shows that the environment has no effect on this product and that this product has good stability.

[0086] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating motion sickness, characterized in that: The invention is composed of the following components in parts by weight: 20-50 parts of lemon, 20-50 parts of forsythia, 10-30 parts of wild chrysanthemum, 3-7 parts of fennel, 5-10 parts of sandalwood, 5-10 parts of bark scutellaria, 10-20 parts of tangerine peel, 2-5 parts of evodia rutaecarpa, 5-10 parts of patchouli, 15-30 parts of borneol and 15-30 parts of mint.

2. The Chinese medicine composition according to claim 1, characterized in that The invention is composed of the following components in parts by weight: 25-40 parts of lemon, 25-40 parts of forsythia, 15-25 parts of wild chrysanthemum, 4-6 parts of fennel, 7-9 parts of sandalwood, 7-9 parts of bark scutellaria, 12-18 parts of tangerine peel, 3-4.5 parts of evodia rutaecarpa, 7-9 parts of patchouli, 18-25 parts of borneol and 18-25 parts of mint.

3. The Chinese medicine composition according to claim 1 or 2, characterized in that The invention is composed of the following components in parts by weight: 30 parts of lemon, 30 parts of forsythia, 20 parts of wild chrysanthemum, 5 parts of fennel, 8 parts of sandalwood, 8 parts of bark scutellaria, 15 parts of tangerine peel, 4 parts of evodia rutaecarpa, 8 parts of patchouli, 20 parts of borneol and 20 parts of mint.

4. The method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The steps include: (1) Soaking Scutellaria barbata and Evodia rutaecarpa, then mixing with lemon, forsythia, wild chrysanthemum, fennel, sandalwood, tangerine peel, patchouli, and mint, and boiling for 1 to 3 times, combining the decoctions, filtering, and concentrating the filtrate to obtain a concentrated solution; (2) Mixing borneol with the concentrated solution to obtain a composition.

5. The preparation method according to claim 4, characterized in that The soaking time is 10 to 30 minutes.

6. The preparation method according to claim 4, characterized in that The decoction time is 15 to 40 minutes per time, and the decoction temperature is 90 to 100°C.

7. The preparation method according to claim 4, characterized in that The concentration is performed under reduced pressure, the concentration temperature is 35-55° C., and the volume after concentration is 2 / 5-3 / 5 of the original volume.

8. The preparation method according to claim 4, characterized in that The dosage form of the composition is a spray.

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