A compound weight-loss product containing white kidney beans, and its preparation method and application

Abstract

The invention discloses a compound weight-loss product containing white kidney bean. The compound weight-loss product is prepared by extracting and adding auxiliary materials from the following raw materials in parts by weight: 20-30 parts of white kidney bean, 12-28 parts of Poria cocos, 10-20 parts of Coix seeds, 8-12 parts of cinnamon twigs, 15-25 parts of Atractylodes macrocephala, 10-20 parts of Alisma orientalis, 20-30 parts of Plantago seeds, 20-30 parts of Lycium barbarum, 8-12 parts of Bupleurum chinense, 15-25 parts of dried tangerine peel, 10-20 parts of Salvia miltiorrhiza, and 10-20 parts of Angelica sinensis. The compound weight-loss product containing white kidney bean for treating obesity of spleen deficiency and dampness excess type is a pure traditional Chinese medicine prescription, has good clinical efficacy, can lower blood lipids according to modern pharmacological research, and has little toxic and side effects. In addition, the compound weight-loss product has a wide source of medicine and low cost, is of great significance for further improving the clinical efficacy of traditional Chinese medicine in treating obesity of spleen deficiency and dampness excess type, and is suitable for clinical promotion and application.

Description

[0001] This application is a divisional application of application number 202310531324.7, application date May 12, 2023, and invention name “A compound weight loss product containing white kidney beans, its preparation method and application”. Technical Field

[0002] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a compound weight-loss product containing white kidney beans and a preparation method thereof. Background Art

[0003] Obesity is a chronic metabolic disease characterized by excessive fat accumulation and / or abnormal distribution, leading to weight gain. It is caused by the interaction of multiple factors, including genetics and the environment. Obesity can lead to an increased incidence of certain cancers, primarily colorectal and prostate cancers in men, and endometrial, ovarian, cervical, breast, and gallbladder cancers in women. Therefore, proactive and effective treatment of obesity can effectively reduce the risk of other diseases and improve quality of life.

[0004] Obesity is primarily attributed to the spleen and stomach. "Medical Practice, Volume 4" states: "A strong constitution is due to congenital factors... Generally, those with strong constitutions experience no suffering, except for an abundance of dampness and phlegm." This suggests that physical constitution is influenced to some extent by congenital factors. Innate deficiencies can lead to spleen and kidney deficiency. Acquired dietary restrictions, a predilection for fatty and sweet foods, overeating, and prolonged periods of excessive eating and little exercise can also lead to dysfunction of the spleen and stomach's function. Modern people live at a fast pace and experience high mental stress. Emotional frustration and stagnant liver qi can affect the spleen, while prolonged worry and anxiety can damage the spleen. Impaired spleen function allows the accumulation of phlegm and dampness, which accumulate as fat and accumulate in the abdomen, resulting in obesity. Obesity caused by spleen deficiency and excessive dampness primarily manifests as obesity, a potbelly, swollen limbs, fatigue, loss of appetite, indigestion, and dry mouth. Spleen deficiency and dampness are the etiology and pathogenesis in Traditional Chinese Medicine theory, mainly referring to the retention of dampness due to spleen and stomach dysfunction, which causes obesity symptoms. Summary of the Invention

[0005] The main purpose of this application is to provide a compound weight loss product containing white kidney beans with good efficacy, high efficiency, short treatment course, small toxic and side effects, and low cost, and a preparation method thereof.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] A compound weight-loss product containing white kidney bean is prepared by extracting and adding auxiliary materials from the following raw materials in parts by weight: 20-30 parts of white kidney bean, 12-28 parts of Poria cocos, 10-20 parts of Coix seeds, 8-12 parts of cinnamon twigs, 15-25 parts of Atractylodes macrocephala, 10-20 parts of Alisma orientalis, 20-30 parts of Plantago seeds, 20-30 parts of Lycium barbarum, 8-12 parts of Bupleurum chinense, 15-25 parts of dried tangerine peel, 10-20 parts of Salvia miltiorrhiza, and 10-20 parts of Chinese angelica.

[0008] The compound weight-loss product containing white kidney bean is prepared by extracting and adding auxiliary materials of the following raw materials in parts by weight: 22-30 parts of white kidney bean, 12-20 parts of Poria cocos, 10-15 parts of Coix seeds, 10-12 parts of cinnamon twigs, 15-20 parts of Atractylodes macrocephala, 10-18 parts of Alisma orientalis, 20-25 parts of Plantago seeds, 10-30 parts of Lycium barbarum, 8-10 parts of Bupleurum chinense, 15-20 parts of dried tangerine peel, 10-15 parts of Salvia miltiorrhiza, and 15-20 parts of Chinese angelica.

[0009] The compound weight-loss product containing white kidney bean is prepared by extracting and adding the following raw materials in parts by weight: 25 parts of white kidney bean, 20 parts of Poria cocos, 15 parts of Coix seeds, 10 parts of cinnamon twigs, 20 parts of Atractylodes macrocephala, 15 parts of Alisma orientalis, 25 parts of Plantago seeds, 25 parts of wolfberry, 10 parts of Bupleurum root, 20 parts of dried tangerine peel, 15 parts of Salvia miltiorrhiza, and 15 parts of Chinese angelica.

[0010] The auxiliary materials of the compound weight-loss product containing white kidney beans are the following raw materials in parts by weight: 30-50 parts of sucrose and 100-250 parts of dextrin.

[0011] The preparation method of the compound weight-loss product containing white kidney bean comprises the following steps:

[0012] (1) Each of the above raw materials was decocted with water for 2 times, each time for 60-120 minutes. After the extraction was completed, the extracts were combined, filtered, and concentrated;

[0013] (2) adding ethanol to the concentrate obtained in step (1), stirring the mixture evenly, allowing the mixture to stand, collecting the supernatant, filtering, and concentrating the mixture to obtain a clear paste;

[0014] (3) Add sucrose and dextrin to the clear paste, mix and stir evenly, prepare soft material, granulate, dry, and shape the granules to obtain the compound weight loss product containing white kidney bean.

[0015] In the preparation method of the compound weight-loss product containing white kidney bean, in step (1), the amount of water added during decoction is 10 times the weight of the medicinal material raw material.

[0016] In the preparation method of the compound weight-loss product containing white kidney beans, in step (2), the amount of ethanol added is the weight of the concentrate.

[0017] In the preparation method of the compound weight loss product containing white kidney beans, in step (3), the drying is performed at a temperature of 50° C. for 2 hours.

[0018] White kidney beans, also known as Phaseolus vulgaris, are native to Central and South America. They were introduced to China by the Spanish in the 16th century and are now found in Yunnan, Guangdong, Guangxi Zhuang Autonomous Region, and Fujian. They thrive in fertile, sunny locations. They are primarily propagated by cuttings and sowing. They have a sweet, mild flavor and a neutral nature. They have nourishing, antipyretic, diuretic, and detumescent properties, and are particularly effective in treating edema and beriberi.

[0019] Modern medical research has shown that white kidney beans contain highly active α-amylase inhibitors, which inhibit α-amylase from blocking starch breakdown. When consumed with other fiber-rich foods, white kidney beans not only help maintain satiety but also inhibit sugar absorption, aiding weight loss. Because α-amylase reduces glucose absorption, white kidney beans can also prevent postprandial blood sugar spikes, helping to control blood sugar levels. White kidney beans are neutral in nature and sweet in taste, harmonizing the qi of the spleen and stomach, promoting downward flow of stomach qi and preventing upward flow. They can also alleviate symptoms such as vomiting and hiccups caused by stomach cold. Their primary benefits are strengthening the spleen and eliminating dampness, dispelling heat and relieving summer heat. From a Traditional Chinese Medicine (TCM) dietary perspective, white kidney beans are sweet in nature and enter the spleen. Therefore, consuming them can effectively alleviate nausea, abdominal pain, bloating, and diarrhea caused by spleen deficiency and dampness.

[0020] Poria cocos is the dried sclerotium of the Polyporaceae fungus Poria cocos (Schw.) Wolf. It is usually harvested between July and September, cleaned of mud and sand, piled to "sweat," and then spread out to air dry. This process is repeated several times until wrinkles appear and most of the internal moisture has been lost. The resulting pieces are then dried in the shade, known as "Poria cocos pieces." Alternatively, fresh Poria cocos can be cut into different parts and dried in the shade, becoming known as "Poria cocos peels" and "Poria cocos blocks." It enters the heart, lung, spleen, and kidney meridians. Its nature and flavor are sweet, mild, and neutral. It primarily promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind. It is used for edema, oliguria, phlegm and fluid retention, dizziness and palpitations, spleen deficiency, poor appetite, loose stools, restlessness, palpitations, and insomnia.

[0021] Job's tears are the dried, mature kernels of the grass plant Coix lacryma-jobi L. var. mayuen (Roman.) Stapf. The plants are harvested in autumn when the fruits are ripe, sun-dried, and the fruits are beaten and sun-dried again. The shells, yellowish-brown seed coats, and impurities are removed, and the kernels are collected. It enters the spleen, stomach, and lung meridians. It has a sweet, light, and cooling effect. It strengthens the spleen, dispels dampness, relieves numbness and stops diarrhea, and clears heat and expels pus. It is used to treat edema, beriberi, dysuria, dampness-induced stiffness and cramps, spleen deficiency diarrhea, lung abscesses, intestinal abscesses, and flat warts.

[0022] Cinnamon twigs are the dried young branches of Cinnamomum cassia (Cinnamomum cassia Presl), a plant of the Lauraceae family. Harvested in spring and summer, the leaves are removed and sun-dried, or sliced ​​and sun-dried. They enter the heart, lung, and bladder meridians. Pungent, sweet, and warming, they induce sweating and relax muscles, warm and unclog the meridians, invigorate yang and transform qi, and balance and descend qi. They are used to treat colds, abdominal pain due to cold blood, amenorrhea, joint pain, phlegm and fluid retention, edema, palpitations, and typhoid fever.

[0023] Atractylodes macrocephala is the dried rhizome of Atractylodes macrocephala Koidz., a plant of the Asteraceae family. It is harvested in winter when the lower leaves turn yellow and the upper leaves become brittle. The soil is removed and the leaves are dried in an oven or sun-dried. The fibrous roots are then removed. It enters the spleen and stomach meridians. Bitter, sweet, and warming, it invigorates the spleen and replenishes qi, dispels dampness and promotes diuresis, stops sweating, and stabilizes the fetus. It is used for spleen deficiency, poor appetite, abdominal distension and diarrhea, phlegm and fluid retention, dizziness and palpitations, edema, spontaneous sweating, and restless fetuses. Atractylodes macrocephala is a Chinese herb that invigorates the spleen, harmonizes the stomach, and stabilizes the fetus. It is used for spleen deficiency, poor appetite, diarrhea, loose stools, and restless fetuses.

[0024] Alisma orientalis (Sam.) Juzep., a plant of the Alismataceae family, is harvested in winter when the stems and leaves begin to wither. It is then washed, dried, and the fibrous roots and rough bark removed. It enters the kidney and bladder meridians. It is sweet and cold. It promotes urination and clears dampness and heat. It is used for dysuria, edema, diarrhea, oliguria, phlegm and fluid retention, dizziness, painful stranguria due to heat, and hyperlipidemia.

[0025] Plantago seeds are the dried, mature seeds of Plantago asiatica L. or Plantago depressa Willd., both members of the Plantaginaceae family. The seeds are harvested in summer and autumn when they mature, sun-dried, and rubbed to remove the seeds and remove impurities. They enter the liver, kidney, lung, and small intestine meridians. They are sweet and slightly cold. They clear heat, promote urination, dissipate dampness, relieve stranguria, improve eyesight, and eliminate phlegm. They are used for edema, painful stranguria caused by heat, diarrhea due to summer heat and dampness, red and swollen eyes, and cough caused by phlegm and heat.

[0026] Goji berries are the dried, mature fruit of Lycium barbarum L., a plant of the Solanaceae family. They are harvested in summer and autumn when they turn red, dried with hot air, and the stems removed. Alternatively, they can be air-dried until the skin wrinkles, then sun-dried and the stems removed. They enter the liver and kidney meridians. They are sweet and neutral. They nourish the liver and kidneys, improve essence and vision, and are used for asthenia, low back pain, vertigo, tinnitus, internal heat, and thirst, blood deficiency, and sallow complexion.

[0027] Bupleurum chinense DC. or Bupleurum corzonerifolium Willd. (Apiaceae) are the dried roots of Bupleurum chinense DC. or Bupleurum corzonerifolium Willd., both commonly known as "Northern Bupleurum" and "Southern Bupleurum" depending on their properties. It is harvested in spring and autumn, the stems, leaves, and mud removed, and then dried. It enters the Liver and Gallbladder Meridians. It is bitter and slightly cold. It harmonizes the exterior and interior, soothes the liver, and promotes yang. It is used for colds, fever, alternating chills and fever, chest and flank pain, menstrual irregularities, uterine prolapse, and rectal prolapse.

[0028] Tangerine peel (Chenpi) is the dried, mature peel of the Rutaceae plant, Citrus reticulata Blanco, and its cultivated varieties. It is divided into two medicinal herbs: "Chenpi" (Chenpi) and "Guangchenpi" (Guangchenpi). The ripe fruit is harvested, the peel removed, and then sun-dried or low-temperature dried. It enters the lung and spleen meridians. It is bitter, pungent, and warming. It regulates qi and strengthens the spleen, dissipates dampness, and resolves phlegm. It is used to treat chest and abdominal distension, loss of appetite, vomiting, diarrhea, and cough with excessive phlegm.

[0029] Danshen (Salvia miltiorrhiza) is the dried root and rhizome of the Lamiaceae plant Salvia miltiorrhiza Bunge. It is harvested in spring and autumn, desilted, and dried. It enters the Heart and Liver meridians. It is bitter and slightly cold. Its functions include removing blood stasis and relieving pain, promoting blood circulation and menstruation, and clearing the heart and relieving restlessness. It is used for menstrual irregularities, amenorrhea, dysmenorrhea, accumulation of lumps and masses, stabbing pain in the chest and abdomen, pain due to heat rheumatic arthritis, sores and swelling, restlessness and insomnia, hepatosplenomegaly, and angina pectoris.

[0030] Angelica sinensis is the dried root of Angelica sinensis (Oliv.) Diels, a plant in the Umbelliferae family. It is harvested in late autumn, the fibrous roots and sediment removed, and after the moisture has evaporated slightly, bundled into small bundles, hung on a shed, and slowly smoked over a fire. It enters the liver, heart, and spleen meridians. It is sweet, pungent, and warming. It nourishes and invigorates blood circulation, regulates menstruation and relieves pain, and moistens the intestines and promotes bowel movements. It is used for sallow complexion due to blood deficiency, dizziness and palpitations, irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to cold deficiency, constipation caused by dry intestines, rheumatic pain, injuries from falls, carbuncles, and ulcers. Angelica sinensis wine is used to invigorate blood circulation and regulate menstruation. It is used for amenorrhea, dysmenorrhea, rheumatic pain, and injuries from falls.

[0031] Obese individuals often suffer from spleen and kidney yang deficiency. This can be caused by insufficient kidney yang, which fails to stimulate spleen yang, dietary biases that damage the spleen and stomach, or emotional distress and stagnant qi, which can lead to liver qi attacking the stomach. A weakened spleen and stomach fail to function properly, preventing fluid distribution and causing internal dampness and turbidity. Phlegm, qi stagnation, and blood stasis interact with each other, forming a stagnant state. The progression of obesity begins with dampness in the spleen and stomach, which then spreads to the liver, leading to liver-spleen imbalance and metabolic disorders. Chronic illness can affect the kidneys, leading to both spleen and kidney deficiency. Kidney essence and qi are significantly reduced, weakening the power to drive organ function and causing physiological decline. The kidneys are the foundation of innate constitution, storing primordial yin and yang. In old age, the kidneys fail to store essence and qi, gradually depleting them. Simultaneously, the function of the spleen and stomach (connected to the Yangming meridian) and the liver (connected to the Jueyin meridian) also weakens. Kidney Qi deficiency and spleen Qi deficiency interact, making it difficult for the spleen and stomach to transport and transform food and transpire fluids. This impedes the proper distribution of essence and body fluids, which accumulate over time and transform into phlegm, dampness, and turbid fat, gradually leading to obesity. Because Yi and Gui share the same origin, this depletion of kidney primordial Yin and the inability of water to contain wood can lead to liver Yin deficiency and yang hyperactivity. Furthermore, the liver's function of dispersing and dispersing Qi is weakened, impacting the spleen and stomach's ability to transport and transform food and to raise the clear and lower the turbid. This leads to Qi stagnation, food accumulation, and phlegm and dampness in the body, preventing their excretion and elimination, resulting in obesity. The predominant syndrome is spleen deficiency and dampness excess obesity. This refers to obesity caused by spleen deficiency and dampness excess, characterized by symptoms such as obesity, a potbelly, limb edema, fatigue, loss of appetite, indigestion, and dry mouth and thirst. Since spleen deficiency and dampness are the main causes of obesity, the present invention adopts white kidney bean, Poria cocos and Coix seed to strengthen the spleen and eliminate dampness. At the same time, the spleen and stomach are weak and cannot function properly, and water is not distributed. Cinnamon twig and Atractylodes macrocephala are used to warm yang and eliminate dampness. They are all monarch drugs. Essence and body fluid cannot be normally distributed, and accumulate over time and turn into phlegm, dampness and fat turbidity. Alisma orientalis and Plantago seed are used to penetrate dampness and eliminate dampness. They are minister drugs. Kidney qi deficiency and spleen qi deficiency interact with each other, and water cannot contain wood, leading to liver yin deficiency. Therefore, wolfberry, bupleurum and tangerine peel are used to strengthen the kidney, soothe the liver and regulate qi as adjuvant drugs. At the same time, since the liver's function of dispersing qi is weakened, leading to blood stasis, Salvia miltiorrhiza and Chinese angelica are used to promote blood circulation and remove blood stasis. The whole prescription is compatible and can play the role of strengthening the spleen and eliminating dampness, strengthening the kidney, soothing the liver and regulating qi, and promoting blood circulation and removing blood stasis to treat obesity of spleen deficiency and dampness. DETAILED DESCRIPTION

[0032] In order to help those skilled in the art better understand the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to examples. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work should fall within the scope of protection of the present invention.

[0033] The compound weight-loss product containing white kidney bean of the present invention can be in the form of granules (powder), pills, tablets, capsules and the like.

[0034] Example 1

[0035] A compound weight-loss product containing white kidney bean comprises the following raw materials in parts by weight: 25g white kidney bean, 20g Poria cocos, 15g Coix seed, 10g cinnamon twig, 20g Atractylodes macrocephala, 15g Alisma orientale, 25g Plantago seed, 25g wolfberry, 10g Bupleurum root, 20g dried tangerine peel, 15g Salvia miltiorrhiza, 15g Chinese angelica, 50g sucrose, and 250g dextrin.

[0036] The method for preparing the compound weight-loss product containing white kidney bean described in Example 1 comprises the following steps:

[0037] (1) Each of the above raw materials was decocted and extracted twice with water, with the amount of water added each time being 10 times the weight of the raw material, and each extraction lasted 40 minutes. After the extraction was completed, the extracts were combined, filtered, and concentrated;

[0038] (2) adding ethanol to the concentrate obtained in step (1), stirring the mixture uniformly, allowing the mixture to stand, collecting the supernatant, filtering, and concentrating the mixture to obtain a clear paste; the amount of ethanol added is equal to the weight of the concentrate;

[0039] (3) Add sucrose and dextrin to the clear paste, mix and stir evenly, prepare a soft material, granulate, dry at a temperature of 50° C. for 2 hours, and granulate to obtain the compound weight loss product containing white kidney beans, and prepare it into granules.

[0040] Example 2

[0041] A compound weight-loss product containing white kidney bean comprises the following raw materials in parts by weight: 30g white kidney bean, 12g Poria cocos, 20g Coix seed, 8g cinnamon twig, 25g Atractylodes macrocephala, 10g Alisma orientalis, 30g Plantago seed, 20g wolfberry, 12g Bupleurum chinense, 15g dried tangerine peel, 20g Salvia miltiorrhiza, 10g Chinese angelica, 50g sucrose, and 100g dextrin.

[0042] The method for preparing the compound weight-loss product containing white kidney bean described in Example 2 comprises the following steps:

[0043] (1) Each of the above raw materials was decocted and extracted twice with water, with the amount of water added each time being 10 times the weight of the raw material, and each extraction lasting 50 minutes. After the extraction was completed, the extracts were combined, filtered, and concentrated;

[0044] (2) adding ethanol to the concentrate obtained in step (1), stirring the mixture uniformly, allowing it to stand, collecting the supernatant, filtering it, and concentrating it to obtain a clear paste; the amount of ethanol added is equal to the weight of the concentrate;

[0045] (3) Add sucrose and dextrin to the clear paste, mix and stir evenly, prepare a soft material, granulate, dry at a temperature of 50° C. for 2 hours, and granulate to obtain the compound weight loss product containing white kidney beans, and prepare it into tablets.

[0046] Example 3

[0047] A compound weight-loss product containing white kidney bean comprises the following raw materials in parts by weight: 20g white kidney bean, 28g Poria cocos, 10g Coix seed, 12g cinnamon twig, 15g Atractylodes macrocephala, 20g Alisma orientalis, 20g Plantago seed, 30g wolfberry, 8g Bupleurum chinense, 25g dried tangerine peel, 10g Salvia miltiorrhiza, 20g Chinese angelica, 30g sucrose, and 250g dextrin.

[0048] The method for preparing the compound weight-loss product containing white kidney bean described in Example 3 comprises the following steps:

[0049] (1) Each of the above raw materials was decocted and extracted with water twice, with the amount of water added each time being 10 times the weight of the medicinal material, and each extraction lasted 60 minutes. After the extraction was completed, the extracts were combined, filtered, and concentrated;

[0050] (2) adding ethanol to the concentrate obtained in step (1), stirring the mixture uniformly, allowing the mixture to stand, collecting the supernatant, filtering, and concentrating the mixture to obtain a clear paste; the amount of ethanol added is equal to the weight of the concentrate;

[0051] (3) Add sucrose and dextrin to the clear paste, mix and stir evenly, prepare a soft material, granulate, dry at a temperature of 50° C. for 2 hours, and granulate to obtain the compound weight loss product containing white kidney beans, which is prepared into capsules.

[0052] Example 4: Experimental study on the effects of the present invention on mouse weight and serum biochemical indicators

[0053] 1. Experimental materials: 60 male SD mice, weighing 16-20 g (provided by the Experimental Animal Center of Yunnan University of Traditional Chinese Medicine), and an enzymatic serum assay kit (Shanghai Fusheng Industrial Co., Ltd.).

[0054] 2. Experimental drugs: the clear paste prepared by the method of Example 1 of the present invention, and homemade high-nutrition feed (10 g milk powder, 10 g lard, 1 egg, 10 drops of cod liver oil).

[0055] 3. Experimental Procedure

[0056] 3.1 Experimental Animal Grouping: 30 mice were randomly divided into 3 groups, with 10 mice in each group, namely the normal group, the model group and the invention group.

[0057] 3.2 Animal husbandry: The mice in the normal group were fed with ordinary mouse chow, while the mice in the model group and the present invention group were fed with homemade high-nutrition feed for 30 consecutive days. The mice in the three groups were free to eat. The temperature of the breeding environment was 20-28°C and the humidity was 60%-70%.

[0058] 3.3 Drug administration to experimental animals

[0059] The mice in the present invention group were gavage-fed with 0.2 mL of the clear paste prepared in Example 1 of the present invention per mouse, once a day, while the mice in the normal group and the model group were gavage-fed with an equal amount of distilled water for 30 consecutive days.

[0060] 4. Observation indicators and statistical methods

[0061] The effects of the present invention on the weight and fat coefficient of mice, and the total cholesterol and triglyceride levels in the mice serum were observed. The data were statistically analyzed using Excel 2003 software, and the measurement data were expressed as standard deviation (x±s).

[0062] 5 Animal Experiment Results

[0063] 5.1 Effect of the present invention on the body weight of mice. The changes in the body weight of mice before and after the experiment are shown in Table 1.

[0064] Table 1 Changes in mouse body weight before and after the experiment (x±s)

[0065]

[0066] Compared with the model group: *P<0.05, **P<0.01

[0067] As shown in Table 1, the model group mice initially gained less weight than the normal group, but in the later stages of the experiment, their weight exceeded that of the normal group, indicating that the nutritious feed had a weight-increasing effect. The weight gain rate of the mice in Group 1 of the present invention was significantly lower than that of the normal and model groups, indicating that the present invention has a weight-reducing effect. Statistical analysis results showed that the difference in weight change between the model group and the normal group was significant (P < 0.05), and that the weight gain of the mice in Group 1 of the present invention was extremely significantly different from that of the model group (P < 0.01).

[0068] 5.2 Effects of the present invention on total cholesterol and triglycerides in mouse serum

[0069] After 30 days of feeding, mice were sacrificed and blood was collected from the heart for serum separation (blood was allowed to rest for 30 minutes, centrifuged at 3000 rpm for 15 minutes, and the supernatant was collected). The mice were fasted for 16 hours before blood collection. Serum total cholesterol and triglyceride levels were measured using enzymatic kits (see Table 2 for details).

[0070] Table 2 Effects of total cholesterol and triglycerides in mouse serum (x±s)

[0071]

[0072]

[0073] Compared with the model group: *P<0.05, **P<0.01

[0074] As shown in Table 2, the serum total cholesterol and triglyceride concentrations of the model group mice were significantly higher (P < 0.05) than those of the normal group, demonstrating that the nutritious feed can significantly increase the serum total cholesterol and triglyceride concentrations of mice. The serum total cholesterol and triglyceride concentrations of the mice in the Example 1 group were extremely significantly lower (P < 0.01) than those in the model group, indicating that the present invention has a significant lipid-lowering effect.

[0075] Example 5: Clinical efficacy evaluation of the composition for treating obesity of spleen deficiency and dampness excess type according to the present invention

[0076] 1. Case source: 120 obese patients with spleen deficiency and dampness excess type who visited the hospital from January 2022 to January 2023 were selected.

[0077] 2. Diagnostic criteria: Refer to the "Guidelines for the Prevention and Control of Overweight and Obesity in Adults in China" issued by the Department of Disease Control of the Ministry of Health of China in April 2003 and the "Guidelines for the Diagnosis and Treatment of Obesity in Primary Care" issued by the Chinese Medical Association in 2019: Adults 24.0kg / m2≤BMI<28.0kg / m 2 Overweight, ≥28.0 kg / m 2 Obesity; central obesity can be determined by waist circumference: a waist circumference of 85 to <90 cm for men and 80 to <85 cm for women is in the early stage of central obesity, and a waist circumference of ≥90 cm for men and ≥85 cm for women is central obesity.

[0078] 3. Case selection: (1) Meet the diagnostic criteria for simple obesity in Western medicine; (2) Meet the diagnostic criteria for obesity in Traditional Chinese Medicine; Specifically: Spleen deficiency and dampness excess type obesity refers to obesity caused by spleen deficiency and dampness excess, mainly manifested by symptoms such as obesity, potbelly, limb edema, fatigue, loss of appetite, indigestion, dry mouth and thirst. (3) Good compliance, cooperate with treatment and nursing, and have no special dietary habits; (4) Have not received other weight loss treatments in the past 3 months; (5) Aged between 18 and 60 years old; (6) Be conscious, sign the relevant informed consent form, and voluntarily participate in the study.

[0079] 4. Case exclusion criteria: (1) Those who do not meet the diagnostic criteria and have secondary obesity caused by other reasons: hyperadrenocortical insufficiency, hypothyroidism, pituitary diseases, hypogonadism and drug-induced obesity; (2) Patients with severe diseases of the heart, liver, kidney and other organs or blood system diseases; (3) Those under 18 years old or over 60 years old; (4) Those who have been allergic to multiple Chinese medicines or are known to have sensitive constitutions; (5) Those with poor compliance, unable to persist in treatment or unable to cooperate with treatment and follow-up visits; (6) Those with mental or intellectual disabilities and unwilling to cooperate; (7) Pregnant or lactating women.

[0080] 5. Efficacy evaluation criteria: (1) Recovery: Weight reaches the standard weight range, body mass index (BMI) < 24 kg / m2 (2) Significantly effective: The patient's weight loss is more than 5 kg (including 5 kg), and the body mass index (BMI) decreases by ≥4 kg / m 2 (3) Effective: Weight loss of 2-5 kg ​​(including 2 kg), BMI reduction of 2 to <4 kg / m2; (4) Ineffective: No weight loss or weight loss of less than 2 kg, BMI reduction of <2 kg / m2. Total effective rate = (number of markedly effective cases + number of effective cases) / total number of cases x 100%.

[0081] 6. Treatment process: The granule product prepared in Example 1 of the present invention was taken three times a day, two bags each time, each bag containing 15 grams of Chinese medicine, for one month. The body weight, body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), serum total cholesterol (TC), triglyceride (TG) and other indicators of the two groups were observed before and after treatment. The results are shown in Table 3.

[0082] Table 3. Comparison of weight, BMI, waist circumference, hip circumference, WHR, TC, and TG before and after treatment (x±s)

[0083] Observation indicators Before treatment After treatment Weight(Kg) 75.45±6.79 <![CDATA[67.82±7.13 * ]]> <![CDATA[BMI(Kg / m 2 )]]> 34.65±4.82 <![CDATA[29.36±3.05 * ]]> Waist circumference (cm) 92.54±6.35 86.90±5.23 Hips (cm) 108.69±9.25 102.49±7.53 WHR (%) 85.14±3.41 84.79±4.18 TC (mmol / L) 5.67±1.58 <![CDATA[3.97±1.12 * ]]> TG (mmol / L) 2.37±0.92 <![CDATA[1.76±0.71 ** ]]>

[0084] Compared with before treatment: *P<0.05, **P<0.01

[0085] 7. Results: The weight, BMI, TC, and TG before and after treatment were compared. The weight, BMI, waist circumference, hip circumference, WHR, TC, and TG were all reduced compared with those before treatment (P < 0.05). The waist circumference, hip circumference, and WHR were all reduced compared with those before treatment, indicating that the present invention has a good effect on treating phlegm-dampness type obesity with a long course of disease.

[0086] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A compound weight loss product containing white kidney beans, characterized in that: The preparation is prepared by extracting and adding auxiliary materials of the following raw materials in parts by weight: 22-30 parts of white kidney bean, 12-20 parts of Poria cocos, 10-15 parts of coix seed, 10-12 parts of cinnamon twig, 15-20 parts of atractylodes macrocephala, 10-18 parts of oriental rhizome, 20-25 parts of plantain seed, 10-30 parts of wolfberry, 8-10 parts of bupleurum, 15-20 parts of dried tangerine peel, 10-15 parts of salvia miltiorrhiza, and 15-20 parts of angelica sinensis. The auxiliary materials are the following raw materials in parts by weight: 30-50 parts of sucrose and 100-250 parts of dextrin. The preparation method comprises the following steps: (1) Each of the above raw materials was decocted with water for 2 times, each time for 60-120 minutes. After the extraction was completed, the extracts were combined, filtered, and concentrated; (2) adding ethanol to the concentrate obtained in step (1), stirring the mixture evenly, allowing the mixture to stand, collecting the supernatant, filtering, and concentrating the mixture to obtain a clear paste; (3) Add sucrose and dextrin to the clear paste, mix and stir evenly, prepare soft material, granulate, dry, and shape the granules to obtain the compound weight loss product containing white kidney bean.

2. The compound weight-loss product containing white kidney beans according to claim 1, characterized in that: The preparation is prepared by extracting and adding the following raw materials in parts by weight: 25 parts of white kidney bean, 20 parts of Poria cocos, 15 parts of Coix seeds, 10 parts of cinnamon twigs, 20 parts of Atractylodes macrocephala, 15 parts of Alisma orientalis, 25 parts of Plantago seeds, 25 parts of Lycium barbarum, 10 parts of Bupleurum chinense, 20 parts of dried tangerine peel, 15 parts of Salvia miltiorrhiza, and 15 parts of Chinese angelica.

3. The compound weight loss product containing white kidney beans according to claim 1, characterized in that: In step (1) of the preparation method, the amount of water added during decoction is 10 times the weight of the medicinal material.

4. The compound weight loss product containing white kidney bean according to claim 1, characterized in that: In step (2) of the preparation method, the amount of ethanol added is the weight of the concentrate.

5. The compound weight loss product containing white kidney bean according to claim 1, characterized in that: In step (3) of the preparation method, the drying is performed at a temperature of 50° C. for 2 hours.

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