An inhibitor of a march1 protein

By expressing the MARCH1 protein to inhibit the transfer of gB, gD, gH, and gL proteins in pseudorabies virus and block intercellular fusion, the limitations of MARCH1 in herpesvirus replication were addressed, and effective inhibition of pseudorabies virus was achieved.

CN118416203BActive Publication Date: 2026-06-02YIBIN VOCATIONAL & TECH COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
YIBIN VOCATIONAL & TECH COLLEGE
Filing Date
2024-04-09
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

In the prior art, the role of MARCH1 in herpesvirus replication has not been fully explored, especially its limited inhibitory effect on pseudorabies virus (PRV), and its mechanism in the viral replication process is still unclear.

Method used

By expressing or using the MARCH1 protein and its derivatives, isolated nucleic acid molecules, vectors containing the MARCH1 protein, or host cells, the transfer of gB, gD, gH, and gL proteins in pseudorabies virus (PRV) is inhibited, cell-to-cell fusion is blocked, and viral replication is thus suppressed.

Benefits of technology

The MARCH1 protein significantly inhibits pseudorabies virus replication, blocks gB cleavage, limits viral transmission between cells, reduces viral titer, decreases cell fusion, and effectively controls viral infection.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application belongs to the field of biological medicine and virus infection, and particularly relates to an inhibitor for limiting virus-mediated cell-cell fusion. The application specifically discloses an inhibitor for limiting cell-cell fusion mediated by pseudorabies virus (PRV), wherein the inhibitor contains MARCH1 protein, and the MARCH1 protein includes a derivative thereof, an isolated nucleic acid molecule, a vector or a host cell containing the MARCH1 protein, and / or a fusion. It is found in the research that MARCH1 significantly inhibits the replication of PRV in the stage of cell-cell fusion, that is, it is found in the application that MARCH1 captures a virus protein complex inducing cell-cell fusion in a trans-Golgi network (TGN), and it is proved that MARCH1 has anti-PRV infection activity.
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