An anti-periodontal pathogen polypeptide, a polypeptide solution and application thereof

CN118515731BActive Publication Date: 2025-10-17HENAN UNIV OF SCI & TECH
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Patent Information

Application Number
CN202410689097.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-05-30
Publication Date
2025-10-17
Estimated Expiration
2044-05-30

AI Technical Summary

Benefits of technology

[0020]1. The anti-periodontal pathogenic polypeptide provided by the application can efficiently inhibit and kill Porphyromonas gingivalis, Fusobacterium nucleatum and Streptococcus mutans, has good stability, and has very low toxicity. The polypeptide has the potential to be developed into an anti-Porphyromonas gingivalis, Fusobacterium nucleatum and Streptococcus mutans mouthwash, an antibacterial gel, and a toothpaste additive, and is used for preventing and treating periodontal infections caused by Porphyromonas gingivalis, Fusobacterium nucleatum and Streptococcus mutans.

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Abstract

The application relates to the medical application field, and particularly discloses an anti-periodontal pathogenic bacteria polypeptide, a polypeptide solution and application thereof, and the amino acid sequence of the antibacterial polypeptide is Lys-Thr-Lys-Ile-Gly-Ile-Asn-Gly-Phe-Gly-Lys-Ile-Gly-Lys-Leu-Val-Leu-Lys. The polypeptide provided by the application can effectively inhibit periodontal pathogenic bacteria Porphyromonas gingivalis, Fusobacterium nucleatum and Streptococcus mutans, and has extremely small toxicity to human red blood cells. The polypeptide can be developed into a drug, a mouthwash, an antibacterial gel and a toothpaste additive for resisting Porphyromonas gingivalis, Fusobacterium nucleatum and Streptococcus mutans infection.
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