Acupoint massage and sleep-aiding ginseng compound essential oil and preparation method thereof

Abstract

The invention relates to the technical field of biopharmaceuticals, and discloses a ginseng compound essential oil for acupoint massage and aiding sleep. The essential oil is a high-concentration compound essential oil medicine designed according to the principle of human acupoint massage in traditional Chinese medicine, aromatherapy, neurotransmitter imbalance theory, etc. The essential oil is compounded with ginseng alcohol extract or ginseng essential oil, lavender essential oil, menthol, vanillin or ethyl vanillin, jojoba oil or almond oil, and the total proportion of ginseng alcohol extract or ginseng essential oil, lavender essential oil and menthol is ≥50wt%. The components in the compound essential oil of the invention cooperate with each other, and aromatherapy and massage therapy are implemented synchronously through in vitro coating and massage of acupoints such as Ren Zhong by traditional Chinese medicine, and the essential oil has four functions of smelling fragrance, acupoint stimulation, percutaneous absorption and meridian conduction, and can significantly improve the difficulty of people with sleep disorders or patients falling asleep, and prolong the deep sleep time, and can significantly improve the symptoms of sleep disorders of most people in the population.

Description

Technical Field

[0001] The invention relates to the technical field of medicine and health care, and in particular to a ginseng compound essential oil for auxiliary treatment of acupoint massage and sleep-aiding and a preparation method thereof, and can improve symptoms of anxiety, insomnia and depression. Background Art

[0002] The compound massage essential oil in the prior art refers to a product composed of multiple essential oils and other ingredients added to the essential oils to improve their quality. The product is not a cosmetic directly applicable to human skin but a medicine or health care product. When used, it is generally necessary to dilute it with a massage base oil (the concentration of the active ingredient is generally 2~5wt%) and apply it to the skin by smearing or massage.

[0003] In the prior art, sleep disorder refers to the situation that it is difficult to fall asleep, maintain sleep or wake up early, and is accompanied by a decrease in sleep quality, also known as insomnia. Insomnia is a common sleep disorder, and its etiology is complex and involves multiple factors. The causes of insomnia are multifaceted, mainly related to psychological factors, such as anxiety, depression, stress and psychological pressure, which are common causes of insomnia. Mental tension and mood swings may interfere with sleep. Secondly, physiological factors, especially diseases or physical discomfort, such as pain, breathing problems, frequent urination, etc., can interfere with sleep. Certain diseases such as heart failure, respiratory diseases and nervous system diseases may also cause insomnia. The third is drug factors, such as antidepressants, diuretics, hormone drugs, caffeine and other stimulant drugs, which may interfere with sleep and cause insomnia. The fourth is environmental factors, and poor sleeping environment, such as noise, light and temperature, may also have adverse effects on sleep. In addition, lifestyle factors are also very important, such as irregular sleep, long-term use of electronic devices, overeating, lack of physical activity and other lifestyle factors are also related to insomnia. The pathogenesis of insomnia involves many biological processes such as neurotransmitters, hormones, and brain electrical activity. The pathogenesis of insomnia is related to neurotransmitters such as dopamine, norepinephrine, and 5-hydroxytryptamine, which play an important role in sleep regulation. Their imbalance may be related to insomnia. Dopamine is an excitatory neurotransmitter that plays an activating and awakening role in sleep regulation. The release of dopamine can increase alertness and wakefulness, while inhibiting sleep. Norepinephrine is an excitatory neurotransmitter that participates in maintaining wakefulness and attention. Its increase is associated with increased alertness. Serotonin is an inhibitory neurotransmitter that plays an important role in the regulation of sleep. It participates in regulating the sleep-wake rhythm and promotes sleep onset and sleep stability. Melatonin is an endogenous hormone that controls the sleep rhythm, and its secretion is regulated by daylight and darkness. Abnormal secretion of melatonin may lead to insomnia.

[0004] The treatment of insomnia mainly uses drugs with sedative and hypnotic effects. The sedative and hypnotic effects mainly depend on the dosage of the drug. A small dose is a sedative, a medium dose is a hypnotic, and a large dose is an anesthetic. The sedative and hypnotic drugs currently on the market are mainly: (1) Traditional sedative and hypnotic drugs: barbiturates and benzodiazepines. Barbiturates can significantly reduce the number of awakenings and increase sleep time. However, these drugs have significant side effects and are addictive. Overdose can easily lead to death. Benzodiazepines are safer and have better therapeutic effects. Their mechanism is mainly to promote the release of γ-aminobutyric acid (GABA). (2) Non-benzodiazepine drugs, such as zolpidem and zaleplon, mainly target GABA receptors to induce hypnosis. Although these drugs have significant therapeutic effects, long-term use can lead to drug dependence, excessive sedation, drowsiness, dizziness, headache, cognitive impairment, and motor incoordination. There are still some problems with drug treatment. In clinical applications, many people are not suitable for or inconvenient to use these Western medicines. Modern medicine still has many urgent problems to solve in the treatment of insomnia. The conventional treatment of insomnia in traditional Chinese medicine is oral decoction and acupuncture treatment. However, oral decoction has the disadvantage of damaging the spleen and stomach, and acupuncture has the concern of patients dizzy. The use of herbal essential oils to promote sleep through aromatherapy is a modern medical treatment method that is being promoted in recent years. Aromatherapy, which uses the aroma molecules of herbal essential oils as a medicine, is transmitted to the limbic system of our brain through the olfactory nerves, mobilizing the connection between people's sense of smell and good memories, thereby producing a good physiological feeling of muscle relaxation and emotional relief. Aromatherapy is a highly fragrant plant petals, branches and leaves that are extracted, absorbed through the pores of the human body, penetrate into the deep tissues of the endothelium and the fat part, and exert its therapeutic effect through blood circulation. Aromatherapy has a long history in my country. There are a large number of scattered records in the literature of traditional Chinese medicine in successive dynasties, and it is also widely circulated among the people.

[0005] Acupressure is a traditional Chinese medicine that is widely used for health care and treatment of diseases. Relatively few studies have examined the effects of acupressure on anxiety, insomnia, and depression in patients with chronic heart failure, but some preliminary studies suggest that it may have a positive effect on improving patients' psychological symptoms. The results of these studies suggest that acupressure may help improve psychological symptoms, including anxiety, insomnia, and depression, in patients with chronic heart failure. Acupressure and essential oil massage are common therapies in traditional Chinese medicine and aromatherapy, and are believed to promote the body's self-healing function and relax the mood. Some early studies suggest that these therapies may have a positive effect on improving anxiety, insomnia, and depression, but their mechanism of action has not been revealed, and there is currently no acupressure sleep-aiding ginseng essential oil specifically designed for acupressure to achieve a rapid onset of effect and maintain the efficacy for a long time.

[0006] The compound essential oils in the prior art often lack clear theoretical basis for their compounding methods and efficacy as medicines or health care products. They are usually fumigated (aromatherapy) or applied all over the body, and cannot be closely combined with Chinese medicine acupoint massage therapy. In addition, the concentration of their active ingredients is low (usually 2-5wt%, if the concentration is too high, it is easy to burn the skin), the efficacy is slow to take effect, the duration is short, and they cannot take into account aromatherapy and massage therapy, etc. For example, Chinese invention patent document CN201410686372.4 discloses a massage oil suitable for insomnia, and Chinese invention patent document CN201510429366.5 discloses an external composition for improving sleep and its preparation method, etc.

[0007] Therefore, it is necessary to improve the design of compound massage essential oils in the prior art in many aspects based on the national standard GB / T 26516-2011 "Massage Essential Oils" and other specifications, and combine compatibility, therapy, clarify its mechanism and improve its efficacy. Summary of the invention

[0008] In order to overcome the above-mentioned deficiencies in the above-mentioned prior art, the present invention provides a ginseng compound essential oil for acupoint massage to help sleep and a preparation method thereof, with the focus on improving the formula, preparation method, etc. of the ginseng compound essential oil for acupoint massage to help sleep according to the combination of acupoint massage, aromatherapy and meridian conduction, so as to improve the concentration of the effective ingredient without damaging the skin. In particular, according to the theory of neurotransmitter imbalance of insomnia, ginseng alcohol extract is used in a targeted manner. The ginseng compound essential oil for acupoint massage to help sleep or a medical and health product is a high-concentration compound essential oil designed according to the principles of human acupoint massage in traditional Chinese medicine, aromatherapy, neurotransmitter imbalance theory, etc., and is compounded by ginseng alcohol extract or ginseng essential oil, lavender essential oil, menthol, vanillin or ethyl vanillin, jojoba oil or almond oil, and the total proportion of ginseng alcohol extract or ginseng essential oil, lavender essential oil and menthol is ≥50wt%. The components in the compound essential oil of the present invention cooperate with each other, and aromatherapy and massage therapy are implemented simultaneously through external coating and massage of acupoints such as Ren Zhong in traditional Chinese medicine, which has four functions of smelling aroma, acupoint stimulation, percutaneous absorption, and meridian conduction, can significantly improve the difficulty of people with sleep disorders or patients falling asleep, and prolong the deep sleep time, and can significantly improve the sleep disorder symptoms of most people in this group.

[0009] To achieve the above purpose, the technical solution provided by the present invention is:

[0010] A ginseng compound essential oil for acupoint massage and sleep aid, which is prepared by compounding ginseng alcohol extract or ginseng essential oil, lavender essential oil, menthol, vanillin or ethyl vanillin, jojoba oil or almond oil, wherein the ginseng alcohol extract or ginseng essential oil accounts for 5-25wt%, the lavender essential oil accounts for 30-50wt%, the menthol accounts for 1-10wt%, the vanillin or ethyl vanillin accounts for 0.5-5wt%, and the jojoba oil or almond oil accounts for 20-35wt%; and the ginseng alcohol extract or ginseng essential oil, lavender essential oil, menthol, vanillin or ethyl vanillin account for 5-25wt%, the lavender essential oil accounts for 30-50wt%, the menthol accounts for 1-10wt%, the vanillin or ethyl vanillin accounts for 0.5-5wt%, and the jojoba oil or almond oil accounts for 20-35wt%; , menthol and the total proportion of the three is ≥50wt%; wherein, the ginseng alcohol extract is prepared by the following method: slice the effective part of ginseng medicinal material, add 25 times of 70~80wt% ethanol aqueous solution by weight, soak for 2 hours, heat in a water bath and maintain a constant temperature of 80°C, reflux twice, extract for 50 minutes, cool to room temperature, filter, concentrate, and dry to obtain a solid ginseng alcohol extract; when used, the human acupoints to be applied and massaged on the body surface include: Ren Zhong point, temple, Shenmen point, Anmian point, Sanyinjiao point, Zusanli point, and Weiyongquan point.

[0011] A method for preparing acupoint massage sleep-aiding ginseng compound essential oil, characterized in that it comprises the following steps:

[0012] S1: preparing ginseng alcohol extract or ginseng essential oil in advance;

[0013] S2: weigh ginseng alcohol extract or ginseng essential oil, lavender essential oil, menthol, jojoba oil or almond oil, and vanillin or ethyl vanillin according to proportion;

[0014] S3: heating the lavender essential oil in a water bath at 50-80°C, then adding the ginseng alcohol extract or ginseng essential oil, and then adding vanillin or ethyl vanillin, stirring or shaking continuously to completely dissolve the ginseng alcohol extract or ginseng essential oil, vanillin or ethyl vanillin in the lavender essential oil, and cooling to room temperature;

[0015] S4: Finally, add jojoba oil or almond oil, stir or shake to evenly mix the components to obtain the acupoint massage and sleep-aiding ginseng compound essential oil, which is bottled and sealed for storage.

[0016] The beneficial effects of the present invention are at least embodied in the following aspects:

[0017] 1. The invention provides acupoint massage and sleep-aiding ginseng compound essential oil and its preparation method. The focus is on improving the formula and preparation method of the acupoint massage and sleep-aiding ginseng compound essential oil medicine according to the combination of acupoint massage, aromatherapy and meridian conduction, so as to increase the concentration of effective ingredients without damaging the skin. In particular, according to the neurotransmitter imbalance theory of insomnia, ginseng alcohol extract is used in a targeted manner. The acupoint massage and sleep-aiding ginseng compound essential oil is a high-concentration compound essential oil designed according to the principles of human acupoint massage in traditional Chinese medicine, aromatherapy, neurotransmitter imbalance theory, etc. It is compounded by ginseng alcohol extract or ginseng essential oil, lavender essential oil, menthol, vanillin or ethyl vanillin, jojoba oil or almond oil, and the total proportion of ginseng alcohol extract or ginseng essential oil, lavender essential oil and menthol is ≥50wt%. The components in the compound essential oil of the present invention cooperate with each other, and aromatherapy and massage therapy are implemented simultaneously through external coating and massage of acupoints such as Ren Zhong in traditional Chinese medicine, which has four functions of smelling aroma, acupoint stimulation, percutaneous absorption, and meridian conduction, can significantly improve the difficulty of people with sleep disorders or patients falling asleep, and prolong the deep sleep time, and can significantly improve the sleep disorder symptoms of most people in this group.

[0018] 2. According to the neurotransmitter imbalance theory of insomnia, the present invention adopts ginseng alcohol extract or ginseng essential oil in combination with other components to regulate the level of neurotransmitters, such as increasing the content of 5-hydroxytryptamine (5-HT), which helps to relieve depression symptoms, enhance mood and improve sleep quality; it combines with lavender essential oil to promote the secretion of melatonin. The sleep-aiding compound massage essential oil composed of these two substances can better relieve depression symptoms and play a sleep-aiding role. In the formulation of this sleep-aiding compound massage essential oil, ginseng alcohol extract or ginseng essential oil and lavender oil play a core role.

[0019] 3. The present invention is designed according to the research progress of modern medicine on the cause and pathogenesis of insomnia, on the basis of the experience of Chinese medicine in applying aromatherapy and massage therapy to treat sleep disorders, etc., in accordance with the theoretical model of the compatibility of monarch, minister, assistant and envoy in Chinese medicine formula, the principle of human acupoint massage and the meridian conduction theory of Chinese medicine, and provides a high-concentration acupoint massage sleep-aiding ginseng compound essential oil medicine that can be directly used (without dilution) for external massage of human acupoints to prevent, improve and treat insomnia symptoms, and the core ingredients of the medicine, ginseng alcohol extract or ginseng essential oil, lavender essential oil and menthol, account for ≥50wt% in total. Through reasonable compatibility design, the effective ingredient concentration is high, the effect is fast, and the duration of the therapeutic effect is long. Through external massage of acupoints such as Ren Zhong and Anmian, the main massage areas are the head and face, the bladder meridian on both sides of the waist and back, and the three yin meridians of the foot on the inner side of the calf. The essential oil is directly applied to the skin where the acupoints are located for massage operation, which can better solve the clinical problems such as anxiety and insomnia of some ordinary people with milder symptoms, and significantly improve the symptoms of people and patients with more serious sleep disorders. This essential oil, through the combination of Chinese medicine's acupoint massage therapy, aromatherapy and meridian theory, can take effect quickly through olfactory perception, acupoint stimulation, subcutaneous absorption, and meridian conduction, and the therapeutic effect can be maintained for a long time. It has a significant effect on solving sleep disorders in most people.

[0020] 4. The acupoint massage and sleep-aiding ginseng compound essential oil provided by the present invention does not need to be diluted when used, and can be used directly after opening the bottle, which is convenient and quick, and does not damage the skin; the compound essential oil is applied to the body surface before sleep and massages the acupoints such as "ren zhong" in vitro, which can solve clinical problems such as anxiety and insomnia for some ordinary people with mild symptoms through the sense of smell and skin channels. This product is compounded by multiple components, and the specific ratio has a certain adjustment range, which can be adjusted according to individual differences; this product helps to relax the mood, relieve tension and anxiety symptoms, improve difficulty in falling asleep, and prolong deep sleep time for most people with mild sleep disorders through acupoint massage or smelling aroma.

[0021] 5. The acupoint massage sleep-aiding ginseng compound essential oil of the present invention is a "strong combination" of essential oil, massage, acupoints and meridians. There are multi-level synergistic cooperation, mutual complementation and enhanced efficacy between the various components of the essential oil, between the essential oil and massage, acupoints and meridians; the small molecule components in the essential oil first enter the human brain through the sense of smell, and quickly play a sedative and tranquilizing role; acupoint massage can accelerate the percutaneous absorption of the essential oil components on the acupoints and conduction through the meridians through acupoint stimulation, and take effect quickly, and after the essential oil enters the blood, the efficacy is relatively prolonged; the essential oil components are all plant extracts, which are highly safe and will not damage the skin at high concentrations. Actual tests show that when the essential oil provided by the present invention enters the acupoints related to sleep through the skin, the acupoints can be chemically stimulated, and the physical stimulation of the acupoints by superimposed massage can play a faster, better and more lasting role in regulating sleep and preventing diseases and health care than simple coating or simple massage.

[0022] 6. The acupoint massage sleep-aiding ginseng compound essential oil provided by the present invention is packaged in a sealed bottle, which is ready for use and convenient to use. It is thoroughly absorbed after use without any residue, and is clean and safe. It does not have high requirements for acupoint positioning (large coating area) and massage techniques (a variety of methods are acceptable). It is not difficult for ordinary people and professionals to use it, and no special training is required, which is conducive to large-scale promotion and application.

[0023] 7. The method for preparing the acupoint massage sleep-aiding ginseng compound essential oil provided by the present invention can, on the one hand, ensure the full dissolution of the components, especially the full dissolution of vanillin, and on the other hand, reduce the volatilization loss of the essential oil active substances (including aromatic components) during the preparation process; thirdly, the preparation method provided by the present invention obtains a finished compound essential oil medicine with a high concentration of active ingredients, which can be used after being sealed in a bottle without further dilution, and is convenient for ordinary consumers to purchase, store and use. DETAILED DESCRIPTION

[0024] The technical solution of the present invention is described in detail below through embodiments.

[0025] Basic Example

[0026] The acupoint massage sleep-aiding ginseng compound essential oil provided in an embodiment of the present invention is based on the theory of neurotransmitter imbalance of insomnia, adopts ginseng alcohol extract or ginseng essential oil to cooperate with other components to adjust the level of neurotransmitters, and is specifically a medicine or health care product prepared by compounding ginseng alcohol extract or ginseng essential oil, lavender essential oil, menthol, vanillin or ethyl vanillin, jojoba oil or almond oil, wherein the ginseng alcohol extract or ginseng essential oil accounts for 5-25wt%, the lavender essential oil accounts for 30-50wt%, the menthol accounts for 1-10wt%, the vanillin or ethyl vanillin accounts for 0.5-5wt%, and the jojoba oil or almond oil accounts for 20-35wt%; and And the total proportion of ginseng alcohol extract or ginseng essential oil, lavender essential oil and menthol is ≥50wt%; wherein, the ginseng alcohol extract is prepared by the following method: slice the effective part of ginseng medicinal material, add 25 times of 70~80wt% ethanol aqueous solution by weight, soak for 2 hours, heat in a water bath and maintain a constant temperature of 80°C, reflux twice, extract for 50 minutes, cool to room temperature, filter, concentrate, and dry to obtain a solid ginseng alcohol extract; when in use, the compound essential oil is applied to the body surface and massaged on the human acupoints including: Ren Zhong point, temple, Shenmen point, Anmian point, Sanyinjiao point, Zusanli point, Weiyongquan point, etc., follow the doctor's advice for specific treatment, or refer to the recommended plan in this product manual.

[0027] The preparation method of the aforementioned acupoint massage sleep-aiding ginseng compound essential oil comprises the following steps:

[0028] S1: preparing ginseng alcohol extract or ginseng essential oil in advance;

[0029] S2: weigh ginseng alcohol extract or ginseng essential oil, lavender essential oil, menthol, jojoba oil or almond oil, and vanillin or ethyl vanillin according to proportion;

[0030] S3: heating the lavender essential oil in a water bath at 50-80°C, then adding the ginseng alcohol extract or ginseng essential oil, and then adding vanillin or ethyl vanillin, stirring or shaking continuously to completely dissolve the ginseng alcohol extract or ginseng essential oil, vanillin or ethyl vanillin in the lavender essential oil, and cooling to room temperature;

[0031] S4: Finally, add jojoba oil or almond oil, stir or shake to evenly mix the components to obtain the acupoint massage and sleep-aiding ginseng compound essential oil, which is bottled and sealed for storage.

[0032] The acupoint massage sleep-aiding ginseng compound essential oil provided in this embodiment, the functions of its components and the formulation principle are briefly described as follows:

[0033] Ginseng (Panax ginseng) is a traditional Chinese medicine with a long history. Its roots are rich in active ingredients, among which ginsenosides are one of the main components. As a bioactive substance, ginsenosides have multiple pharmacological effects and therefore have received widespread attention. The main source of ginsenosides is the root of ginseng, which mainly includes Oriental ginseng (Panax ginseng) and Western ginseng (Panax quinquefolius). These plants contain saponin components and polysaccharide components of different types and contents. Among them, ginsenosides Rg1, Rb1, Rg3, Re, etc. and ginseng polysaccharides are the components with the most research on sleep and the highest content. Ginsenosides and polysaccharides have a significant effect on sleep, which helps to improve sleep quality and relieve sleep disorders. Its specific mechanism of action is related to the following factors: (1) Anti-anxiety effect: Ginsenosides have an anti-anxiety effect, which can relieve anxiety symptoms and help relax the mood, thereby improving anxiety-related sleep problems such as difficulty falling asleep; (2) Antidepressant effect: Ginsenosides can regulate the level of neurotransmitters, such as increasing the content of 5-hydroxytryptamine (5-HT), which helps to relieve depressive symptoms, improve mood, and improve sleep quality; (3) Regulating the biological clock: Ginsenosides are believed to regulate the body's biological clock, promote the generation and maintenance of sleep, and help establish healthy sleeping habits; (4) Antioxidant effect: Ginsenosides have antioxidant effects, which can reduce the impact of oxidative stress on sleep quality and protect the nervous system from damage. (5) Promoting the balance of neurotransmitters: Ginsenosides can affect the activities of multiple neurotransmitters, such as increasing the content of gamma-aminobutyric acid (GABA) and inhibiting the release of glutamate, thereby regulating the balance of the brain's nervous system and helping to produce sleep. The blood-brain barrier is a highly functional vascular boundary composed of brain endothelial cells, basement membranes, pericytes, and astrocyte end feet. It is indispensable for maintaining the homeostasis of the central nervous system, protecting the brain from toxins while ensuring that nutrients are delivered to the brain. Many drugs fail to work because they cannot successfully pass through the blood-brain barrier. Fortunately, modern research shows that both ginsenosides and ginseng polysaccharides can pass through the blood-brain barrier and exert pharmacological effects. They have been experimentally proven to be potential neuroprotectants. Based on this, according to our subsequent extraction process for the extraction of ginseng's active ingredients, we can simultaneously obtain ginsenosides and ginseng polysaccharides that help sleep, which provides a theoretical basis for us to use the acupuncture points and meridians of traditional Chinese medicine to allow the active ingredients of ginseng to enter the brain through the skin and sense of smell to play a role in helping sleep.

[0034] The present invention has been found through actual use and testing that the ginseng alcohol extract extracted with 70-80wt% ethanol contains ginsenosides and ginseng polysaccharides, which can enter the body through the skin through the acupoint massage method of traditional Chinese medicine, and enter the brain through the meridians of traditional Chinese medicine or the blood system, nervous system or lymphatic system of modern medicine to play a sleep-inducing effect. The ginseng alcohol extract is combined with lavender essential oil and menthol to form a compound with better efficacy.

[0035] Lavender essential oil is an aromatic oil extracted from the lavender plant (scientific name: Lavandula angustifolia). Lavender essential oil aromatherapy is effective for insomnia. The effects of lavender essential oil on insomnia include: (1) Sedative and relaxing effects: Lavender essential oil contains some volatile components, such as linalool and linalyl acetate, which are believed to have sedative and relaxing properties, which can help relieve tension and anxiety and help fall asleep; (2) Influence on sleep hormones: Studies have shown that lavender essential oil may affect the secretion of sleep hormones, such as melatonin. Melatonin is a hormone that regulates sleep. Lavender essential oil may affect sleep by affecting the secretion or action of melatonin; (3) Relieve pain and discomfort: Some insomnia problems may be related to physical discomfort or pain. Lavender essential oil has certain analgesic and anti-inflammatory properties, which may help relieve physical discomfort and thus improve sleep. Both linalool and linalool acetate contained in lavender essential oil are natural compounds that are widely found in plants, especially some herbs and trees. In traditional Chinese medicine and herbal medicine, linalool is widely used to treat various diseases, including insomnia. Some preliminary research results show that linalool and linalool acetate have a positive effect on improving sleep, mainly through the following mechanisms: (1) Sedative and relaxing effects: Linalool and linalool acetate have certain sedative and relaxing effects, which help relieve tension and anxiety, thereby promoting sleep; (2) Influence on neurotransmitters: Linalool and linalool acetate are believed to affect the release and action of neurotransmitters, such as GABA (gamma-aminobutyric acid), which is a neurotransmitter that plays an important role in regulating the inhibition of the central nervous system. Increasing the activity of GABA helps promote relaxation and sleep; (3) Regulating the biological clock: Linalool and linalool acetate are believed to affect the biological clock and help adjust the sleep-wake cycle. Some researchers have used electroencephalograms to study the effects of lavender oil aroma intervention on human sleep and the brain. They found that inhaling lavender aroma before bedtime can increase "slow wave sleep" and subjective sleep quality. Other studies have also reported that inhaling lavender aroma increases theta (4-7Hz) waves throughout the brain when awake. These studies suggest that lavender aroma may promote low-frequency (theta and delta) brain waves, thereby increasing deep sleep and improving personal sleep quality. Some researchers have explored the effects of inhaling lavender essential oil aroma on human sleep through a single-blind method. They observed that inhaling lavender aroma while falling asleep can promote deep sleep. Linalool is a compound that can stimulate parasympathetic neurons and has long been considered a key substance in lavender's role in reducing anxiety and improving sleep quality. Lavender oral extracts containing linalool have been reported to improve sleep quality in patients with anxiety disorders.However, the extract's effects on sleep quality had a long delay (approximately 2 weeks) and did not improve sleep quality in low-anxiety subjects. Given that lavender aroma stimulation can alter brain activity and rapidly improve sleep quality, we believe that inhaled essential oils may affect brain activity through different mechanisms than oral lavender or lavender extract. Combining oral extract ingestion and sleep aromatherapy may achieve better results than either method alone. As insomnia becomes more common in modern society, lavender may provide a safe and effective way to address sleep-related problems.

[0036] Mint is a common aromatic plant whose main active ingredient is menthol. Mint and menthol may have the following effects on insomnia: (1) Sedative and relaxing effects: Menthol has sedative and relaxing properties that can help relieve tension and anxiety, thereby helping to promote sleep. (2) Lowering body temperature: Menthol can stimulate the sensory receptors of the skin, causing a cool sensation on the skin, so it is often used to make soothing and cooling mint creams or mint oils. Lowering body temperature may help regulate sleep because the human body needs to lower its body temperature during the process of falling asleep. (3) Affecting GABA receptors: GABA is a neurotransmitter that plays an important role in the inhibition of the central nervous system, helping to promote relaxation and sleep. Studies have shown that menthol may affect the activity of GABA receptors and increase the effects of GABA, thereby helping to promote calmness and sleep.

[0037] The following is a detailed description of the formulations of several specific embodiments.

[0038] Example 1

[0039] The acupoint massage sleep-aiding ginseng compound essential oil medicine and the preparation method thereof provided in the embodiment of the present invention are basically the same as the aforementioned basic embodiment, except that: the acupoint massage sleep-aiding ginseng compound essential oil has the following components and proportions: 14wt% ginseng alcohol extract, 50wt% lavender essential oil, 2.0wt% menthol, 4wt% vanillin, and 30wt% jojoba oil.

[0040] In the embodiment of the present invention, the combination of ginseng alcohol extract and lavender essential oil is the core component, and menthol is auxiliary. The total proportion of the core active ingredients ginseng alcohol extract, lavender essential oil, and menthol is 68wt%, ≥50wt%, that is, the concentration of each active ingredient is 68wt%, which is much higher than the 2~5wt% of the prior art. Therefore, its therapeutic effect on acupoints is significantly different from similar products, with a fast onset of effect and a longer duration.

[0041] Example 2

[0042] The acupoint massage sleep-aiding ginseng compound essential oil and the preparation method thereof provided in the embodiment of the present invention are basically the same as the aforementioned embodiment 1, except that the components and proportions of the acupoint massage sleep-aiding ginseng compound essential oil are as follows: 24wt% ginseng alcohol extract, 30wt% lavender essential oil, 10wt% menthol, 4wt% ethyl vanillin, and 32wt% almond oil; almond oil replaces jojoba oil as the base oil; ethyl vanillin with better solubility is used instead of vanillin, which is easier to prepare.

[0043] Example 3

[0044] The acupoint massage sleep-aiding ginseng compound essential oil and its preparation method provided in the embodiment of the present invention are basically the same as those in the aforementioned embodiment 1, except that: the acupoint massage sleep-aiding ginseng compound essential oil has the following components and proportions: 25wt% ginseng alcohol extract, 35wt% lavender essential oil, 4.5wt% menthol, 0.5wt% ethyl vanillin, and 35wt% jojoba oil.

[0045] Example 4

[0046] The acupoint massage sleep-aiding ginseng compound essential oil and its preparation method provided in the embodiment of the present invention are basically the same as those in the aforementioned embodiment 1, except that the components and proportions of the acupoint massage sleep-aiding ginseng compound essential oil are as follows: 5wt% ginseng alcohol extract, 50wt% lavender essential oil, 9wt% menthol, 3wt% ethyl vanillin, and 33wt% jojoba oil.

[0047] Example 5

[0048] The acupoint massage sleep-aiding ginseng compound essential oil and its preparation method provided in the embodiment of the present invention are basically the same as the aforementioned embodiment 1, except that the components and proportions of the acupoint massage sleep-aiding ginseng compound essential oil are: 20wt% ginseng essential oil, 45wt% lavender essential oil, 10wt% menthol, 5wt% vanillin, and 20wt% jojoba oil. The ginseng essential oil in the prior art is used to replace the ginseng alcohol extract to simplify the preparation process; however, the effective ingredients in the ginseng essential oil are less than those in the ginseng alcohol extract, and the effect is slightly different, which is not as good as the effect of the ginseng alcohol extract.

[0049] Example 6

[0050] The acupoint massage sleep-aiding ginseng compound essential oil and the preparation method thereof provided in the embodiment of the present invention are basically the same as those in the aforementioned embodiment 1, except that the components and proportions of the acupoint massage sleep-aiding ginseng compound essential oil are as follows: 19 wt % of ginseng alcohol extract, 44 wt % of lavender essential oil, 1 wt % of menthol, 4.5 wt % of ethyl vanillin, and 31.5 wt % of jojoba oil.

[0051] It should be particularly noted that other implementation schemes (product formulas, process methods) and acupoint massage sleep-aiding ginseng compound essential oils selected within the above-described components, ratios, and process ranges of the present invention can all achieve the technical effects of the present invention, so they are not listed one by one.

[0052] The compound essential oil provided by the above embodiment of the present invention also has the following sensory characteristics:

[0053] The smell is pure and natural, with the smell of natural plants. It has a mild smell when it first enters the nose and has an aftertaste. It has strong penetration and pure quality. The essential oil will be evaporated and absorbed by the skin quickly, and will not leave shiny oil components on the skin. It has good fusion, color, bright and transparent: it has strong lipophilicity, and the components after blending are completely integrated with high uniformity.

[0054] The instructions and precautions for use of the compound essential oil provided by the above embodiment of the present invention are as follows: when ordinary people use the compound essential oil of the present invention for home massage, they should do a skin allergy test before receiving the essential oil massage for the first time, and then massage after confirming that they are not allergic to the compound essential oil provided by the present invention; essential oil massage is prohibited for women during pregnancy and lactation, and it should also be used with caution during menstruation; it is prohibited for people with severe heart disease, liver and kidney failure and malignant tumors, and it is not suitable for people with osteoporosis, thrombocytopenic purpura, and skin damage. People with a history of asthma should use it with caution. The present invention is a finished compound essential oil product, which can be used by the same person for a long time, and no adverse reactions have been found.

[0055] In order to observe the effect of the "acupoint massage sleep-aiding ginseng compound essential oil" provided in the above embodiments, the present invention adopts the olfactory acupoint method to evaluate the sleep effect of mice by applying the Ren Zhong acupoint, and proves that the acupoint massage compound essential oil has a very obvious sleep-aiding effect on mice. The experimental method is as follows:

[0056] The experiment used female Kunming mice, weighing about 30g, 8-9 weeks old, SPF grade, provided by Zhuhai Baishitong Biotechnology Co., Ltd. The experimental mice were free to drink water and eat during the breeding period. License number: SCXK (Guangdong) 2020-0051. After the experimental mice were raised for two weeks, the effect of applying "Ginseng Sleep-Aiding Massage Essential Oil" to the Ren Zhong acupoint on the pentobarbital sodium suprathreshold sleep test of mice was observed. The experimental mice were randomly divided into two groups, 10 mice in each group. The mice in the "Acupoint Massage and Sleep-Aiding Ginseng Compound Essential Oil" group used a cotton swab to dip the essential oil, and then applied it to the Ren Zhong acupoint under the mouse's nostrils for 30 seconds, allowing part of the essential oil to enter the central nervous system through the sense of smell, and the other part penetrated into the body through the skin. The control group was smeared with purified water for control; 10 minutes after the two groups of mice were smeared with the experimental drugs, each group of mice was given 45 mg·kg -1Sodium pentobarbital was injected intraperitoneally at a dose of BW (sedative hypnotic: 90 mg sodium pentobarbital + 20 ml saline, intraperitoneal injection volume of 0.1 ml / 10 g·BW), and the injection time was recorded. The disappearance of the "righting reflex" was used as an indicator of animal falling asleep (righting disappeared for more than 60 seconds), and the time from the intraperitoneal injection to the disappearance of the righting reflex was recorded as the sleep latency (min). The animal's righting reflex disappearance time / sleep time, righting reflex recovery time / awakening time were recorded, and the animal's sleep duration (min) was calculated based on the righting reflex recovery time / awakening time minus the righting reflex disappearance time / sleep time. The experimental results are shown in Table 1 (Comparison of sleep latency and sleep duration after essential oil application in mice).

[0057] Table 1

[0058]

[0059] From the results in Table 1, it can be seen that in terms of sleep latency, compared with the control group, the acupoint massage sleep-aiding ginseng compound essential oil (Example 1) group 1 (P = 0.014), acupoint massage sleep-aiding ginseng compound essential oil (Example 2) group 2 (P = 0.020) and acupoint massage sleep-aiding ginseng compound essential oil (Example 3) group 3 (P = 0.045) had a very significantly shortened sleep latency, indicating that the three groups of ginseng sleep-aiding essential oils can significantly shorten the sleep latency of mice, that is, help animals fall asleep quickly. In terms of sleep duration, compared with the control group, the ginseng sleep-aiding essential oil group 1 (P = 0.001), ginseng sleep-aiding essential oil group 2 (P = 0.048) and ginseng sleep-aiding essential oil group 3 (P = 0.045) increased significantly, indicating that these three groups of compound essential oils can increase the duration of sleep time of animals. The research results show that these three groups of ginseng sleep-aiding essential oils applied to the Ren Zhong acupoint of mice have a significant sleep-aiding effect on the mice's sodium pentobarbital suprathreshold sleep test.

[0060] In order to verify the clinical efficacy of the ginseng compound essential oil medicine for acupoint massage and sleep aid provided by each embodiment of the present invention, volunteers who had poor sleep due to various reasons were randomly selected. By using any of the compound essential oils of Examples 1-6 and combining massage of the Ren Zhong acupoint and other acupoints, it has been observed that the volunteers had a good sleep-aiding effect.

[0061] The following is a test of the intervention effect of the compound essential oil provided in the above embodiment of the present invention on insomnia, anxiety, etc. through a clinical case of inhalation aromatherapy combined with essential oil acupoint massage. The test subjects are randomly selected and the test duration is 14 days.

[0062] For professional treatment within the hospital, acupoint massage is used based on the standard provisions of "Acupuncture and Moxibustion". In view of the patient's main complaint and tongue and pulse conditions, acupoints are selected by qualified doctors in the TCM clinic. The patients are given massage twice a day in the TCM clinic's physiotherapy room, with each acupoint massaged for 2 to 3 minutes, for a total of about 15 minutes, in the morning and afternoon respectively. Then the quality of life, anxiety-depression state and efficacy are evaluated respectively. Through testing 50 people, the total effective rate was 96.5%.

[0063] For the general population's self-treatment at home, users are required to follow the doctor's instructions for use of the product, select acupoints by themselves, determine the acupoints to be massaged and the duration of a single massage, as well as the duration of continuous intervention.

[0064] The present invention randomly selects volunteers who have poor sleep due to various reasons. By using the "Ginseng compound essential oil for acupoint massage to help sleep" provided in each embodiment to massage the Ren Zhong acupoint and other acupoints, it has been observed that the volunteers have a good sleep-aiding effect. The following are several cases where the products of the embodiments of the present invention are used:

[0065] Student Zhang, male, 21 years old, said that since entering university, he has suffered from severe insomnia due to multiple pressures such as study pressure, interpersonal communication, life and environmental adaptation, which has caused him to be listless and unable to concentrate in class for many days. He has used a variety of sleep aids with poor results. He was recommended to use the product of Example 1 of the present invention. Before going to bed, he applied it on his philtrum and both temples and gently massaged for 2-3 minutes. During the massage, the aroma of the essential oil soothed his mood.

[0066] Student Shi, male, 18 years old, said that he was depressed after the college entrance examination because of his unsatisfactory grades. He regretted the gap in entering university and had difficulty falling asleep every night. He had used sleep-aiding essential oils but the effect was not good. After being recommended by his classmates, he used the product of Example 2 of the present invention. Half an hour before going to bed, he applied the acupoint massage sleep-aiding ginseng compound essential oil to his temples and philtrum for massage. During the massage, the fragrance of the essential oil calmed his mood and soon he felt sleepy.

[0067] Student Wu, female, 19 years old, said that since her senior year in high school, she had difficulty falling asleep every night due to excessive anxiety and tension. She usually had to lie in bed for 2 to 3 hours before she could gradually fall asleep, and was easily awakened. She had tried Chinese and Western medicine conditioning, but the effect was general, the sleep quality was sometimes good and sometimes bad, and the drug influence caused memory to decline. After being recommended by a classmate to use the product of Example 3 of the present invention, the first time the acupoint massage sleep-aiding ginseng compound essential oil was used, it was felt to be effective.

[0068] Student Li, male, 21 years old, said that he was emotionally troubled and could not get out of the shadow of breaking up. He had no interest in anything in life. He was depressed and had difficulty falling asleep every night. He had used a variety of sleep aid products but they were ineffective. Under the recommendation of his teacher, he used the product of Example 3 of the present invention, and combined acupoint massage with the use of compound essential oil to relieve his emotions.

[0069] Student Liu, female, 20 years old, said that she was deceived by her friends in college and began to become depressed and introverted. She had difficulty falling asleep late at night every night and was worried about her condition in class the next day. She had used Chinese medicine for conditioning, but the effect was not good. After being recommended by her classmates, she started to use the product of Example 4 before going to bed, applying the essential oil to the temples and philtrum and gently massaging. The effect of the essential oil was maximized during the massage, and the calming effect of ginseng relieved her mood.

[0070] In summary, the above embodiments of the present invention provide a compound essential oil medicine or health care product composed of ginseng alcohol extract and lavender essential oil as the core, wherein the different components and active ingredients of different molecular weights cooperate with acupuncture point massage, which can be quickly penetrated into the body through the nasal mucosa, skin, meridians, and orifices, and can penetrate into the deep layer of the skin and enter the blood circulation in a short time, penetrate into the dermis in three minutes, and penetrate into the subcutaneous tissue and the whole body after five minutes, so as to achieve the purpose of improving the effect of eliminating fatigue, reducing nervous tension, relieving tense emotions, relieving stress, and helping sleep. The compound essential oil product of the present invention has a fragrant smell, a simple preparation process, stable quality, and a definite effect; through the mutual cooperation of active ingredients of different molecular weights, it has rapid onset, fast transdermal absorption, no allergy, stimulation, long duration of efficacy, and is easy to use. It is a multifunctional massage product; in addition, because it is a pure natural plant component, it can be completely metabolized by the human body and will not be retained in the human body, and has great market development potential.

[0071] The above description is only an exemplary embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A ginseng compound essential oil for acupoint massage and sleep aid, characterized in that: It is prepared by compounding ginseng alcohol extract or ginseng essential oil, lavender essential oil, menthol, vanillin or ethyl vanillin, jojoba oil or almond oil, wherein the ginseng alcohol extract or ginseng essential oil accounts for 5-25wt%, the lavender essential oil accounts for 30-50wt%, the menthol accounts for 1-10wt%, the vanillin or ethyl vanillin accounts for 0.5-5wt%, and the jojoba oil or almond oil accounts for 20-35wt%; and the total proportion of ginseng alcohol extract or ginseng essential oil, lavender essential oil and menthol is ≥50wt%; wherein the ginseng alcohol extract is prepared by the following method: slice the effective part of ginseng medicinal material, add 25 times of 70-80wt% ethanol aqueous solution by weight, soak for 2 hours, heat in a water bath and maintain a constant temperature of 80°C, reflux twice, extract for 50 minutes, cool to room temperature, filter, concentrate, and dry to obtain a solid ginseng alcohol extract.

2. The acupoint massage sleep-aiding ginseng compound essential oil according to claim 1, characterized in that: The components and proportions thereof are: 14 wt % of ginseng alcohol extract, 50 wt % of lavender essential oil, 2.0 wt % of menthol, 4 wt % of vanillin, and 30 wt % of jojoba oil.

3. The acupoint massage and sleep-aiding ginseng compound essential oil according to claim 1, characterized in that: The components and proportions thereof are as follows: 24 wt % of ginseng alcohol extract, 30 wt % of lavender essential oil, 10 wt % of menthol, 4 wt % of ethyl vanillin, and 32 wt % of almond oil.

4. The acupoint massage and sleep-aiding ginseng compound essential oil according to claim 1, characterized in that: The components and proportions thereof are as follows: 25 wt% of ginseng alcohol extract, 35 wt% of lavender essential oil, 4.5 wt% of menthol, 0.5 wt% of ethyl vanillin, and 35 wt% of jojoba oil.

5. The acupoint massage and sleep-aiding ginseng compound essential oil according to claim 1, characterized in that: The components and proportions thereof are: 5wt% of ginseng alcohol extract, 50wt% of lavender essential oil, 9wt% of menthol, 3wt% of ethyl vanillin, and 33wt% of jojoba oil.

6. The acupoint massage and sleep-aiding ginseng compound essential oil according to claim 1, characterized in that: The components and proportions thereof are: 20 wt% of ginseng essential oil, 45 wt% of lavender essential oil, 10 wt% of menthol, 5 wt% of vanillin, and 20 wt% of jojoba oil.

7. The acupoint massage and sleep-aiding ginseng compound essential oil according to claim 1, characterized in that: The components and proportions thereof are as follows: 19 wt % of ginseng alcohol extract, 44 wt % of lavender essential oil, 1 wt % of menthol, 4.5 wt % of ethyl vanillin, and 31.5 wt % of jojoba oil.

8. The acupoint massage and sleep-aiding ginseng compound essential oil according to any one of claims 1 to 7, characterized in that: The acupuncture points of the human body that are coated and massaged on the body surface include: Ren Zhong point, temple, Shenmen point, Anmian point, Sanyinjiao point, Zusanli point, and Yongquan point.

9. A method for preparing the acupoint massage sleep-aiding ginseng compound essential oil according to any one of claims 1 to 8, characterized in that: It includes the following steps: S1: preparing ginseng alcohol extract or ginseng essential oil in advance; S2: weigh ginseng alcohol extract or ginseng essential oil, lavender essential oil, menthol, jojoba oil or almond oil, and vanillin or ethyl vanillin according to proportion; S3: heating the lavender essential oil in a water bath at 50-80° C., then adding the ginseng alcohol extract or ginseng essential oil, and then adding menthol, vanillin or ethyl vanillin, and continuously stirring or shaking to completely dissolve the ginseng alcohol extract or ginseng essential oil, menthol, vanillin or ethyl vanillin in the lavender essential oil, and cooling to room temperature; S4: Finally, add jojoba oil or almond oil, stir or shake to evenly mix the components to obtain a finished product of ginseng compound essential oil for acupoint massage and sleep aid.

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