Non-invasive transcranial electromagnetic phase-locked stimulation system

Abstract

The application provides a non-invasive transcranial electromagnetic phase synchronization stimulation system, comprising a transcranial electric stimulation device and a transcranial magnetic stimulation device; the transcranial electric stimulation device generates a clock signal and electric stimulation with a consistent period and initial phase; the clock signal is sent to an electromagnetic synchronization stimulation control module, a trigger signal is provided by the electromagnetic synchronization stimulation control module, and the clock signal carrying the trigger signal is sent to the transcranial magnetic stimulation device; the transcranial magnetic stimulation device generates transcranial magnetic stimulation with a consistent period and initial phase when the trigger signal is detected; or: the transcranial magnetic stimulation device generates a clock signal and transcranial magnetic stimulation with a consistent period and initial phase; the clock signal is sent to an electromagnetic synchronization stimulation control module, a trigger signal is provided by the electromagnetic synchronization stimulation control module, and the clock signal is sent to the transcranial electric stimulation device; the transcranial electric stimulation device generates electric stimulation when the trigger signal is detected. The application uses the technology of electromagnetic phase synchronization to enrich the brain nerve regulation means and improve the clinical treatment effect.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of electromagnetic stimulation non-invasive treatment, in particular to a non-invasive transcranial electromagnetic phase synchronous stimulation system. BACKGROUND

[0002] Transcranial magnetic stimulation (English full name: Transcranial Magnetic Stimulation; English abbreviation: TMS) and transcranial electrical stimulation (English full name: Transcranial Electrical Stimulation; English abbreviation: TES) are two non-invasive non-invasive neuromodulation techniques. By applying a pulsed magnetic field or a continuous current stimulus to the cerebral cortex, it can have an auxiliary treatment effect on various diseases.

[0003] Among them, transcranial magnetic stimulation applies a pulsed magnetic field with a specific frequency and intensity to a specific cerebral cortex area to induce an induced current in the cortex, affect the electrical activity of neurons, and thus manipulate the excitability and inhibition of neurons. This method can regulate the transmission of neural system signals, and thus affect the activity of brain network function, thereby causing physiological changes in the nervous system to achieve therapeutic effect.

[0004] Among them, transcranial electrical stimulation is a non-invasive safe and low-cost neuromodulation method. Generally, it uses low-intensity current (1-3 mA) to regulate the activity of brain neurons to achieve therapeutic effect.

[0005] Although both treatment methods have certain therapeutic effects, the therapeutic effects are limited to one transcranial stimulation device, and the therapeutic effects are not good. SUMMARY

[0006] The present application provides a non-invasive transcranial electromagnetic phase synchronous stimulation system to solve the problems in the background art.

[0007] The non-invasive transcranial electromagnetic phase synchronous stimulation system comprises a transcranial electrical stimulation device and a transcranial magnetic stimulation device;

[0008] The transcranial electrical stimulation device is used to generate a clock signal and generate a transcranial electrical stimulation according to the period and initial phase of the clock signal;

[0009] The transcranial electrical stimulation device is also used to send the clock signal to an electromagnetic synchronous stimulation control module, and after the electromagnetic synchronous control module performs synchronization processing, the clock signal is sent to the transcranial magnetic stimulation device;

[0010] The transcranial magnetic stimulation device acquires the period and initial phase of the clock signal, and generates a transcranial magnetic stimulation signal consistent with the period and initial phase.

[0011] Or:

[0012] The transcranial magnetic stimulation device is configured to generate a clock signal and generate a transcranial magnetic stimulation according to a period and an initial phase of the clock signal.

[0013] The transcranial magnetic stimulation device is further configured to send the clock signal to an electromagnetic synchronous stimulation control module, and send the clock signal to the transcranial electrical stimulation device after the electromagnetic synchronous control module performs a synchronous process.

[0014] The transcranial electrical stimulation device acquires the period and the initial phase of the clock signal, and generates a transcranial magnetic stimulation signal consistent with the period and the initial phase.

[0015] Optionally, the clock signal carries a trigger signal, and the trigger signal is located at a position of a wave crest, a wave trough or a wave crest and a wave trough of the clock signal. When the transcranial electrical stimulation device or the transcranial magnetic stimulation device receives the trigger signal, the transcranial electrical stimulation device or the transcranial magnetic stimulation device starts to generate a transcranial electrical stimulation signal or a transcranial magnetic stimulation signal.

[0016] Optionally, the synchronous stimulation system further comprises an optical coupling isolation filter circuit connected between the transcranial electrical stimulation device and the transcranial magnetic stimulation device, configured to receive the clock signal, isolate and filter the clock signal to obtain a new clock signal, and send the new clock signal to the transcranial electrical stimulation device or the transcranial magnetic stimulation device, so that the transcranial electrical stimulation device or the transcranial magnetic stimulation device generates a transcranial electrical stimulation or a transcranial magnetic stimulation according to the new clock signal.

[0017] Optionally, the electrical stimulation generated by the transcranial electrical stimulation device comprises a transcranial direct current stimulation, a transcranial direct current oscillation stimulation or a transcranial alternating current stimulation.

[0018] Optionally, the magnetic stimulation generated by the transcranial magnetic stimulation device comprises a repetitive transcranial magnetic stimulation.

[0019] Optionally, the magnetic stimulation generated by the transcranial magnetic stimulation device comprises a burst theta-burst stimulation.

[0020] Optionally, for the transcranial magnetic stimulation, multiple stimulations can be generated at each wave crest or wave trough.

[0021] Optionally, an isolation power module is further connected between the transcranial electrical stimulation device and an external battery.

[0022] Optionally, the synchronous stimulation system further comprises a first upper computer and a second upper computer, the first upper computer is in communication connection with the transcranial electrical stimulation device, and the second upper computer is in communication connection with the transcranial magnetic stimulation device.

[0023] The first host and the second host are configured to set a signal parameter of the clock signal.

[0024] The signal parameter of the clock signal comprises frequency, intensity, duration, initial phase and a position of the trigger signal.

[0025] Optionally, the transcranial electrical stimulation device further comprises a current monitoring module connected with a current sampling circuit of the transcranial electrical stimulation device.

[0026] The non-invasive transcranial electromagnetic phase synchronous stimulation system provided by the application comprises a transcranial electrical stimulation device and a transcranial magnetic stimulation device; a clock signal is generated by one of the transcranial stimulation devices (the transcranial electrical stimulation device or the transcranial magnetic stimulation device) and sent to the other transcranial stimulation device (the transcranial magnetic stimulation device or the transcranial electrical stimulation device); thus, the transcranial electrical stimulation device and the transcranial magnetic stimulation device generate different transcranial stimulation signals according to the same clock signal, i.e., one is transcranial electrical stimulation and the other is transcranial magnetic stimulation, and the two transcranial stimulation signals have the same frequency and the same phase, and both of them act on the patient's cranium; while the prior art only stimulates the patient's cranium through one of the stimulation signals; therefore, compared with the prior art, the application stimulates the patient through two different stimulation signals, can generate more types of stimulation on the patient's cranium, and thus improves the treatment effect. BRIEF DESCRIPTION OF DRAWINGS

[0027] In order to more clearly illustrate the technical solutions in the embodiments of the application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description are some embodiments of the application, and those skilled in the art can also obtain other drawings according to these drawings without any creative effort.

[0028] Figure 1 A connection schematic diagram of a transcranial electrical stimulation device, a transcranial magnetic stimulation device and an electromagnetic synchronous stimulation control module provided by the embodiment of the application;

[0029] Figure 2 A non-invasive transcranial electromagnetic phase synchronous stimulation system schematic diagram provided by the embodiment of the application;

[0030] Figure 3 A transcranial electrical stimulation and transcranial magnetic stimulation schematic diagram provided by the embodiment of the application;

[0031] Figure 4 Another transcranial electrical stimulation and transcranial magnetic stimulation schematic diagram provided by the embodiment of the application;

[0032] Figure 5Another transcranial electrical stimulation and transcranial magnetic stimulation schematic diagram provided by the embodiment of the application;

[0033] Figure 6 is a structural schematic diagram of a transcranial electrical stimulation device according to the embodiment of the application. DETAILED DESCRIPTION

[0034] To make the objectives, technical solutions and advantages of the embodiments of the application clearer, the technical solutions in the embodiments of the application are clearly and completely described below. Obviously, the described embodiments are some but not all of the embodiments of the application. Based on the embodiments in the application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the protection scope of the application. In addition, it should be noted that the embodiments in the application and the features in the embodiments can be combined with each other without conflict. The application will be described in detail below with reference to the drawings and in combination with the embodiments.

[0035] For the transcranial electrical stimulation device and the transcranial magnetic stimulation device, the two are combined to improve the treatment effect. However, the combination of mutual stimulation between electricity and magnetism is difficult, and the fundamental reasons are two. First, from the perspective of electronics, magnetic stimulation may interfere with the signal of electrical stimulation. The strength of electrical stimulation is generally weak, and the output current generally does not exceed 3 mA, and the voltage is also generally within the human body safety voltage of 36 V. In order to make the coil produce a pulse magnetic induction intensity of the order of Tesla, the capacitor needs to be charged to thousands of volts quickly, so the high-voltage magnetic stimulation system may cause certain interference to the control of electrical stimulation. Second, phase synchronization of transcranial magnetic stimulation and electrical stimulation is another difficulty. The existing transcranial electrical stimulation equipment and transcranial magnetic stimulation equipment on the market do not have the function of ensuring phase synchronization when combined.

[0036] On the other hand, the traditional clock synchronization method needs to introduce a relatively long clock line, but the high-frequency oscillation signal is extremely easy to be disturbed by the high-voltage magnetic stimulation system. Based on this, the application proposes a non-invasive transcranial electromagnetic phase synchronization stimulation system, which not only solves the problem of interference of the high-voltage system to the control of electrical stimulation through an isolation power module, but also can realize electromagnetic stimulation at the same frequency and phase, solving the problem that the traditional method is easy to be disturbed. For details, see the following content.

[0037] Figure 1 is a non-invasive transcranial electromagnetic phase synchronization stimulation system according to the embodiment of the application. As shown in Figure 1 , the system comprises a transcranial electrical stimulation device and a transcranial magnetic stimulation device;

[0038] The transcranial electrical stimulation device is used to generate a clock signal, and generate transcranial electrical stimulation according to the period and initial phase of the clock signal.

[0039] The transcranial magnetic stimulation device is further configured to send the clock signal to an electromagnetic synchronization stimulation control module, and send the clock signal to the transcranial electric stimulation device after the electromagnetic synchronization control module performs synchronization processing on the clock signal.

[0040] The transcranial magnetic stimulation device acquires the period and initial phase of the clock signal, and generates a transcranial magnetic stimulation signal consistent with the period and initial phase.

[0041] Alternatively:

[0042] The transcranial magnetic stimulation device is configured to generate a clock signal, and generate a transcranial magnetic stimulation according to the period and initial phase of the clock signal.

[0043] The transcranial magnetic stimulation device is further configured to send the clock signal to an electromagnetic synchronization stimulation control module, and send the clock signal to the transcranial electric stimulation device after the electromagnetic synchronization control module performs synchronization processing on the clock signal.

[0044] The transcranial electric stimulation device acquires the period and initial phase of the clock signal, and generates a transcranial electric stimulation signal consistent with the period and initial phase.

[0045] From the above, it can be seen that both transcranial electric stimulation and transcranial magnetic stimulation can generate a clock signal and send it to another device. The present application example describes the case where the transcranial electric stimulation device generates a clock signal and sends it to the transcranial magnetic stimulation device. For the case where the transcranial magnetic stimulation generates a clock signal and sends it to the transcranial electric stimulation device, it is similar to the case where the transcranial electric stimulation device generates a clock signal and sends it to the transcranial magnetic stimulation device, and the present application does not make a detailed description.

[0046] Wherein, the synchronized stimulation here means stimulation with the same frequency and phase. The same phase means that at the same time, the phases of the two are the same.

[0047] Wherein, the frequency of the clock signal can be determined according to actual needs, such as using a clock signal with a frequency of 10KHZ.

[0048] Wherein, the synchronization processing can be to provide a trigger signal and a synchronization signal.

[0049] When the patient needs transcranial electric stimulation and transcranial magnetic stimulation, the working process of the above non-invasive transcranial electromagnetic phase synchronization stimulation system is as follows:

[0050] First, the output ends of the transcranial electric stimulation device and the transcranial magnetic stimulation device are attached to the patient's head;

[0051] The clock signal is generated by the transcranial electrical stimulation device, and the transcranial electrical stimulation signal with a predetermined duration is generated according to the period and initial phase of the clock signal, so that the transcranial electrical stimulation signal can act on the skull of the patient, and a treatment effect is generated on the patient.

[0052] Meanwhile, the clock signal is sent to the transcranial magnetic stimulation device by the transcranial electrical stimulation device.

[0053] The clock signal is received by the transcranial magnetic stimulation device, and the frequency and initial phase of the clock signal are determined, the frequency of the clock signal is taken as the frequency, and the initial phase of the clock signal is taken as the initial phase, that is, the transcranial magnetic stimulation signal is generated according to the frequency and initial phase of the clock signal, so that the transcranial electrical stimulation signal and the transcranial magnetic signal with the same frequency and initial phase act on the skull of the patient, and the treatment effect is improved.

[0054] In addition, the stimulation duration of the transcranial electrical stimulation and the transcranial magnetic stimulation can be determined according to the condition of the patient, for example, the duration is 20-30 minutes.

[0055] In addition, it should be noted that the stimulation duration of the transcranial electrical stimulation and the transcranial magnetic stimulation is relatively long, and the duration can be 20-30 minutes, so if the clock crystal oscillator of each device is used as the clock, the frequency difference caused by the two clock crystal oscillators will cause the phase error to gradually accumulate, and an unacceptable time error will be caused. Therefore, the same crystal oscillator can be used for clock synchronization, and at this time, a long clock line needs to be introduced between the transcranial electrical stimulation device and the transcranial magnetic stimulation device, and the high-voltage charging and discharging device in the transcranial magnetic stimulation device will introduce high-frequency noise to the clock line, which will greatly interfere with the megahertz-level crystal oscillator clock signal. The method of the present application realizes synchronous stimulation through the synchronization signal, and does not cause interference.

[0056] Optionally, the synchronization processing is to provide a trigger signal, so that the clock signal carries the trigger signal, and the trigger signal is located at a position of a wave crest, a wave trough or a wave crest and a wave trough of the clock signal. When the transcranial electrical stimulation device or the transcranial magnetic stimulation device receives the trigger signal, the transcranial electrical stimulation signal or the transcranial magnetic stimulation signal is generated.

[0057] Further, as shown in Figure 3 When the transcranial magnetic stimulation and the transcranial electrical stimulation are stimulated, the frequency and the initial phase of the two are the same, so the magnetic pulse of the magnetic stimulation at each wave crest, wave trough or wave crest and wave trough of the electrical stimulation corresponds one by one, and the effects of the two can be superimposed to generate a better treatment effect.

[0058] Exemplarily, Figure 3 In the wave trough of the electrical stimulation, the magnetic stimulation is generated, Figure 4 In the wave crest of the electrical stimulation, the magnetic stimulation is generated, Figure 5The magnetic stimulation is generated at the position of the peak and the trough of the electric stimulation.

[0059] Optionally, for the transcranial magnetic stimulation, the stimulation can be generated multiple times at the position of each peak or trough.

[0060] The determination of whether to generate the stimulation once or multiple times at each peak or trough according to the actual treatment needs of the patient improves the diversity of the treatment mode. For example, 1-3 times of magnetic stimulation, Figures 3-5 Taking 2 times of magnetic stimulation as an example.

[0061] In addition, the above-mentioned synchronization processing operation, that is, the operation of providing the trigger signal by the electromagnetic synchronization stimulation control module.

[0062] When the transcranial magnetic stimulation device receives the clock signal, the clock signal is used as a timing clock source to realize accurate clock synchronization. When the transcranial electric stimulation device starts to output the electric current, an upward or downward edge is output at the peak or trough of the sine wave as a reference initial phase. The transcranial magnetic stimulation device receives the synchronization signal carrying the reference initial phase and then starts to control the charging and discharging of the capacitor and the coil of the transcranial magnetic stimulation, so as to output the magnetic stimulation.

[0063] Optionally, referring to Figure 6 , the transcranial electric stimulation device comprises a microcontroller and a conversion and acquisition module; as shown in Figure 6 , the microcontroller is responsible for converting the stimulation parameters input by the PC into corresponding voltage waveforms. These waveforms are converted into analog signals through digital-to-analog conversion (D / A), and are processed through an amplification circuit and a voltage-current conversion circuit, and finally output to the electrode, so that the electric stimulation signal is applied to the patient's skull through the electrode. At the same time, the current sampling circuit converts the output current into a voltage analog signal, and then converts it into a digital signal through a signal conditioning circuit and an analog-to-digital conversion (A / D). The digital signal is transmitted back to the microcontroller, and the microcontroller transmits the real-time current information to the PC through a TTL / RS232 serial interface for display and monitoring on the screen.

[0064] Among them, the microcontroller module can be a 32-bit microcontroller module.

[0065] Optionally, the transcranial electric stimulation device further comprises an isolation power supply module, which is connected between the transcranial electric stimulation device and an external battery.

[0066] The transcranial electric stimulation device is powered by the external power battery, instead of a 220V power supply, so as to avoid the problem of power supply noise caused by the transcranial electric stimulation device when the 220V external power supply network is unstable.

[0067] Further, the isolation power module comprises a power isolation chip and a voltage conversion chip, which can realize isolated and stabilized output, effectively avoiding the interference of the high-voltage power module in the transcranial magnetic stimulation device on the transcranial electric stimulation device, and avoiding the damage to the transcranial electric stimulation device due to the damage or unstable output of the external battery.

[0068] Optionally, the transcranial electric stimulation device further comprises a current monitoring module connected with the current sampling circuit of the transcranial electric stimulation device, for collecting the current of the current sampling circuit to achieve the purpose of monitoring, so as to prevent the current from being too large or too small.

[0069] Optionally, the transcranial magnetic stimulation device comprises a control module, a power module, an energy storage capacitor and a coil.

[0070] The control module is used for managing and regulating the output of the transcranial magnetic stimulation device, and converts the input parameters of the operator (such as stimulation mode, stimulation frequency, stimulation intensity, string interval, string time, etc.) into corresponding control signals to accurately control the power module to charge the energy storage capacitor and the energy storage capacitor to discharge the coil.

[0071] The power module is used for providing sufficient power for the rapid charging of the capacitor, and when the voltage of the capacitor is charged to the set value of the control module, the power module will stop charging the capacitor to ensure that the voltage and current of the coil meet the requirements during discharging.

[0072] The energy storage capacitor is used for storing power to provide sufficient energy for the coil during discharging. The charging rate of the energy storage capacitor is determined according to the design requirements. If a low-power power module is selected for the realization of low-frequency rTMS mode, a power module with larger output power can be selected to improve the charging rate if high-frequency high-intensity rTMS or TBS mode is required.

[0073] The coil is used for generating a pulsed magnetic field acting on the cerebral cortex. The discharge of the coil by the energy storage capacitor will generate a thousand ampere of instantaneous current, thereby generating a pulsed magnetic field of the order of Tesla. The coil can be designed to have a specific structure according to the needs, such as a circular coil, an 8-shaped coil, etc. Compared with the circular coil, the 8-shaped coil has stronger focusing, and the maximum magnetic induction intensity is located at the intersection of the 8-shaped coil, so the stimulation range is more accurate.

[0074] Optionally, referring to Figure 2The synchronization stimulation system further comprises an opto-coupler isolation filter circuit connected between the transcranial electrical stimulation device and the transcranial magnetic stimulation device, configured to receive the clock signal, isolate and filter the clock signal to obtain a new clock signal, and send the new clock signal to the transcranial electrical stimulation device or the transcranial magnetic stimulation device, so that the transcranial electrical stimulation device or the transcranial magnetic stimulation device generates transcranial electrical stimulation or transcranial magnetic stimulation according to the new clock signal.

[0075] The opto-coupler isolation filter circuit not only isolates the two devices and reduces interference between the two devices, but also filters the clock signal.

[0076] Further, since the opto-coupler isolation filter circuit reduces interference between the two devices and also filters the clock signal, the synchronization accuracy is improved, so the opto-coupler isolation filter circuit is also part of the phase synchronization module. Further, the phase synchronization module is part of the electromagnetic synchronization stimulation control module.

[0077] Optionally, the transcranial electrical stimulation device generates transcranial direct current oscillatory electrical stimulation (otDCS) and transcranial alternating current stimulation (TACS), which are also common transcranial electrical stimulation techniques.

[0078] In addition, Figure 1 The transcranial direct current oscillatory electrical stimulation is only an example and does not limit the present application.

[0079] Optionally, the magnetic stimulation generated by the transcranial magnetic stimulation device includes repetitive transcranial magnetic stimulation (rTMS) or theta burst stimulation (TBS).

[0080] In each treatment, any one of the electrical stimulation and any one of the magnetic stimulation can be combined with each other.

[0081] Optionally, the synchronization stimulation system further comprises a first upper computer and a second upper computer, the first upper computer is in communication connection with the transcranial electrical stimulation device, and the second upper computer is in communication connection with the transcranial magnetic stimulation device.

[0082] The first upper computer and the second upper computer are configured to set signal parameters of the clock signal.

[0083] The signal parameters of the clock signal include frequency, intensity, duration, initial phase, and the position of the trigger signal.

[0084] The first host computer and the second host computer are each installed with corresponding control software to facilitate human-computer interaction through the host computer.

[0085] Further, the type of the host computer includes, but is not limited to, a smartphone, a tablet computer, a television, a notebook computer, a desktop computer, etc., and the embodiments of the present application do not make specific limitations thereon.

[0086] The first host computer is installed with electric stimulation control software and electromagnetic synchronization software, and the second host computer is installed with magnetic stimulation control software and electromagnetic synchronization software.

[0087] The electric stimulation control software can be used for an operator to input parameters related to the electric stimulation signal.

[0088] The magnetic stimulation control software is used for an operator to input parameters related to the magnetic stimulation signal.

[0089] The electromagnetic synchronization software is used for an operator to input parameters and instructions related to synchronization control, such as inputting a time for generating a trigger signal, and the first host computer generates an instruction for generating a trigger signal according to the time and sends the instruction to the main control module, which then sends the instruction to the electromagnetic synchronization stimulation control module.

[0090] Further, the electromagnetic synchronization stimulation module is used to provide a trigger signal, such as generating a trigger signal after receiving the instruction for generating a trigger signal and loading the trigger signal onto the clock signal so that the clock signal carries the trigger signal.

[0091] Further, the electromagnetic synchronization stimulation module is also used to provide a synchronization signal.

[0092] In addition, it should be noted that the scope of the present application includes feasible technical solutions formed by specific combinations of the above technical features, and also covers other feasible technical solutions formed by any combination of the above technical features or equivalent features without departing from the concept of the present application.

[0093] Finally, it should be noted that the contents not described in the technical solutions of the present application can be implemented using existing technologies. In addition, the above embodiments are only used to illustrate the technical solutions of the present application, and not to limit them; although the present application has been described in detail with reference to the above embodiments, those skilled in the art should understand that they can modify the technical solutions recorded in the above embodiments, or make equivalent replacements for part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A non-invasive transcranial electromagnetic phase-locked stimulation system, characterized in that, The application relates to a synchronization stimulation system. The transcranial electric stimulation device is used to generate a clock signal and generate transcranial electric stimulation according to the period and initial phase of the clock signal. The transcranial electric stimulation device is also used to send the clock signal to an electromagnetic synchronization stimulation control module, and send the clock signal to the transcranial magnetic stimulation device after synchronization processing by the electromagnetic synchronization control module. The transcranial magnetic stimulation device acquires the period and initial phase of the clock signal and generates transcranial magnetic stimulation signals consistent with the period and initial phase. Alternatively, The transcranial magnetic stimulation device is used to generate a clock signal and generate transcranial magnetic stimulation according to the period and initial phase of the clock signal. The transcranial magnetic stimulation device is also used to send the clock signal to an electromagnetic synchronization stimulation control module, and send the clock signal to the transcranial electric stimulation device after synchronization processing by the electromagnetic synchronization control module. The transcranial electric stimulation device acquires the period and initial phase of the clock signal and generates transcranial electric stimulation signals consistent with the period and initial phase. The clock signal carries a trigger signal, and the trigger signal is located at the position of a wave crest, a wave trough or a wave crest and a wave trough of the clock signal; when the transcranial electric stimulation device or the transcranial magnetic stimulation device receives the trigger signal, the transcranial electric stimulation device or the transcranial magnetic stimulation device starts to generate a transcranial electric stimulation signal or a transcranial magnetic stimulation signal. The synchronization stimulation system further comprises an optical coupling isolation filter circuit connected between the transcranial electric stimulation device and the transcranial magnetic stimulation device, which is used to receive the clock signal, isolate and filter the clock signal to obtain a new clock signal, and send the new clock signal to the transcranial electric stimulation device or the transcranial magnetic stimulation device, so that the transcranial electric stimulation device or the transcranial magnetic stimulation device generates transcranial electric stimulation or transcranial magnetic stimulation according to the new clock signal.

2. The synchronized stimulation system of claim 1, wherein, The electric stimulation generated by the transcranial electric stimulation device comprises transcranial direct current stimulation, transcranial direct current oscillation stimulation or transcranial alternating current stimulation.

3. The synchronized stimulation system of claim 2, wherein, The magnetic stimulation generated by the transcranial magnetic stimulation device comprises repetitive transcranial magnetic stimulation.

4. The synchronized stimulation system of claim 3, wherein, The magnetic stimulation generated by the transcranial magnetic stimulation device comprises burst theta-burst stimulation.

5. The synchronized stimulation system of claim 3, wherein, For the transcranial magnetic stimulation, multiple stimulations can be generated at the position of each wave crest or wave trough.

6. The synchronized stimulation system of claim 1, wherein, An isolation power module is further connected between the transcranial electric stimulation device and an external battery.

7. The synchronized stimulation system of claim 1, wherein, The synchronization stimulation system further comprises a first host computer and a second host computer, the first host computer is in communication connection with the transcranial electric stimulation device, and the second host computer is in communication connection with the transcranial magnetic stimulation device.

8. The synchronized stimulation system of claim 1, wherein, The first host computer and the second host computer are used to set signal parameters of the clock signal. The signal parameters of the clock signal comprise frequency, intensity, duration, initial phase and the position of the trigger signal. The transcranial electric stimulation device further comprises a current monitoring module connected with a current sampling circuit of the transcranial electric stimulation device.

9. The synchronized stimulation system of any one of claims 1-8, wherein, ​

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