A Chinese medicine nose ointment for treating sinusitis and preparation method thereof

Abstract

The invention relates to the technical field of Chinese medicine preparations, and in particular to a Chinese medicine nose ointment for treating sinusitis and a preparation method thereof. The Chinese medicine nose ointment comprises the following raw materials: scutellaria baicalensis, coptis chinensis, phellodendron chinense, gardenia charcoal, rhubarb, bletilla striata, cyperus rotundus, pollen, sanguisorba officinalis charcoal, astragalus and notoginseng powder; the preparation method comprises the following steps: mixing scutellaria baicalensis, coptis chinensis, phellodendron chinense, gardenia charcoal, rhubarb, bletilla striata, cyperus rotundus, pollen, sanguisorba officinalis charcoal, astragalus and notoginseng powder in parts by mass to obtain a mixed medicinal material; crushing the mixed medicinal material into fine powder to obtain medicinal material powder; mixing the medicinal material powder with a carrier material to form a paste; and filling the paste into a container to prepare a finished nose ointment. The finished nose ointment can be used for treating sinusitis, and the uniformity and standardization of components are ensured by a modern preparation method, thereby improving the treatment effect, reducing side effects, and adapting to the needs of a modern medical system, thereby helping to improve the quality of life of patients with sinusitis and providing a safe and effective treatment option.

Description

Technical Field

[0001] The invention relates to the field of Chinese medicine preparations, in particular to a Chinese medicine nose ointment for treating sinusitis and a preparation method thereof. Background Art

[0002] Sinusitis is a respiratory disease characterized by symptoms including nasal congestion, runny nose, headache and facial pain. The disease is usually caused by bacterial or viral infection or allergic reaction, and long-term illness may lead to more serious health problems. Although modern medicine provides a variety of drugs to treat sinusitis, such as antibiotics, anti-allergic drugs and hormones, these treatments are often accompanied by potential side effects, including drug resistance and weakened immune system function, and have limited effectiveness in some patients.

[0003] Traditional Chinese medicine can directly target the cause of sinusitis and reduce side effects by using a combination of natural medicinal materials. However, despite its good therapeutic effects and low side effects, its application in the modern medical system is limited. These limitations include low extraction rate of active ingredients from medicinal materials, poor stability of ingredients, and lack of scientifically verified efficacy. These factors limit the popularity and use of traditional Chinese medicine preparations.

[0004] Therefore, it is very necessary to propose a traditional Chinese medicine nasal ointment and a preparation method thereof that ensures the uniformity and standardization of ingredients through a modern preparation method, thereby improving the therapeutic effect, reducing side effects, and adapting to the needs of the modern medical system. Summary of the invention

[0005] The purpose of the present invention is to provide a traditional Chinese medicine nasal ointment for treating sinusitis and a preparation method thereof, aiming to ensure the uniformity and standardization of ingredients through a modern preparation method, thereby improving the treatment effect, reducing side effects, and adapting to the needs of the modern medical system.

[0006] To achieve the above object, the present invention adopts a Chinese medicine nose ointment for treating sinusitis, which is prepared by the following raw materials in parts by weight:

[0007] Scutellaria baicalensis 10-30g, Coptis chinensis 20-40g, Phellodendron amurense 10-30g, Gardenia charcoal 20-40g, Rhubarb 5-15g, Bletilla striata 5-15g, Imperata cylindrica 20-40g, Pollen Typhae 10-30g, Sanguisorba officinalis charcoal 10-30g, Astragalus 20-40g, Panax notoginseng powder 5-15g.

[0008] The present invention also provides a method for preparing a Chinese medicine nose ointment for treating sinusitis, comprising the following steps:

[0009] Mix scutellaria baicalensis, coptis chinensis, phellodendron amurense, gardenia charcoal, rhubarb, bletilla striata, imperata root, pollen cattail, sanguisorba officinalis charcoal, astragalus and notoginseng powder according to parts by mass to obtain a mixed medicinal material;

[0010] Grinding the mixed medicinal materials into fine powder to obtain medicinal material powder;

[0011] Mixing the medicinal material powder with a carrier material to form a paste;

[0012] The paste is filled into a container to prepare a finished nose paste.

[0013] Wherein, in the step of crushing the mixed medicinal materials into fine powder to obtain medicinal material powder:

[0014] The crushing particle size is 100-300 mesh.

[0015] Wherein, in the step of mixing the medicinal material powder with the carrier material to form a paste:

[0016] The carrier material is one of petrolatum and gel.

[0017] Among them, in the step of filling the paste into a container to prepare a finished nose paste:

[0018] The container is one of a plastic tube body and an aluminum tube body.

[0019] The invention discloses a Chinese medicine nose ointment for treating sinusitis and a preparation method thereof. The ointment comprises 10-30g of scutellaria baicalensis, 20-40g of coptis chinensis, 10-30g of phellodendron amurense, 20-40g of gardenia charcoal, 5-15g of rhubarb, 5-15g of bletilla striata, 20-40g of imperata root, 10-30g of pollen typhae, 10-30g of sanguisorba officinalis charcoal, 20-40g of astragalus and 5-15g of notoginseng powder. The preparation method comprises the following steps: according to parts by mass, scutellaria baicalensis, coptis chinensis, phellodendron amurense, gardenia charcoal, rhubarb, bletilla striata, imperata root, pollen typhae, sanguisorba officinalis charcoal, and coptis chinensis are added. Astragalus and Panax notoginseng powder are mixed to obtain a mixed medicinal material; the mixed medicinal material is crushed into fine powder to obtain medicinal powder; the medicinal powder is mixed with a carrier material to form a paste; the paste is filled into a container to prepare a finished nasal ointment. The finished nasal ointment can be used for the treatment of sinusitis. The uniformity and standardization of the ingredients are ensured through modern preparation methods, thereby improving the treatment effect, reducing side effects, and adapting to the needs of the modern medical system, helping to improve the quality of life of patients with sinusitis and providing a safe and effective treatment option. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0021] Figure 1It is a step flow chart of Example 1 of the present invention.

[0022] Figure 2 It is a step flow chart of Example 2 of the present invention.

[0023] Figure 3 It is a step flow chart of Example 3 of the present invention.

[0024] Figure 4 These are the test results of the inhibitory effect of the Chinese medicine nasal ointment prepared in Examples 1 to 3 of the present invention on the inflammation of the acute sinusitis model.

[0025] Figure 5 These are the test results of the inhibitory effect of the Chinese medicine nasal ointment prepared in Examples 1 to 3 of the present invention on the inflammation of the chronic sinusitis model. DETAILED DESCRIPTION

[0026] The present invention provides a traditional Chinese medicine nose ointment for treating sinusitis, which is prepared from the following raw materials in parts by weight:

[0027] Scutellaria baicalensis 10-30g, Coptis chinensis 20-40g, Phellodendron amurense 10-30g, Gardenia charcoal 20-40g, Rhubarb 5-15g, Bletilla striata 5-15g, Imperata cylindrica 20-40g, Pollen Typhae 10-30g, Sanguisorba officinalis charcoal 10-30g, Astragalus 20-40g, Panax notoginseng powder 5-15g.

[0028] In this embodiment, Scutellaria baicalensis, Coptis chinensis and Phellodendron amurense have significant heat-clearing and detoxifying effects, and can effectively inhibit sinusitis; Gardenia charcoal and Rhubarb provide auxiliary effects of clearing heat and purging fire, helping to remove accumulated heat and toxins; Bletilla striata and Imperata cylindrica help moisten the lungs and relieve coughs, and relieve dry sinuses; Pollen Typhae and Sanguisorba officinalis charcoal promote blood circulation and reduce mucosal bleeding; Astragalus and Panax notoginseng powder enhance immune function and improve the body's resistance to disease. The overall formula is designed to quickly relieve sinusitis symptoms by directly acting on the nasal cavity, improve the local absorption and utilization rate of drugs, and reduce the amount of medicinal materials and reduce costs. The prepared Chinese medicine nasal ointment is not only safe and effective, but also has no toxic and side effects, providing a new treatment option for patients with sinusitis.

[0029] Example 1, please refer to Figure 1 The present invention provides a method for preparing a Chinese medicine nose ointment for treating sinusitis, comprising the following steps:

[0030] S101: Mix 10 g of Scutellaria baicalensis, 20 g of Coptidis rhizome, 10 g of Phellodendron chinense, 20 g of Gardenia charcoal, 5 g of Rhubarb, 5 g of Bletilla striata, 20 g of Imperata cylindrica, 10 g of Pollen Typhae, 10 g of Sanguisorba officinalis charcoal, 20 g of Astragalus membranaceus and 5 g of Panax notoginseng powder, by weight, to obtain a mixed medicinal material;

[0031] S102: Grinding the mixed medicinal materials into fine powder to obtain medicinal material powder;

[0032] S103: mixing the medicinal material powder and petrolatum in a ratio of 1:1, and forming a paste after they are completely blended;

[0033] S104: Filling the paste into a container to prepare a finished nasal paste.

[0034] In this embodiment, 10g of Scutellaria baicalensis, 20g of Coptis chinensis, 10g of Phellodendron chinense, 20g of Gardenia charcoal, 5g of Rhubarb, 5g of Bletilla striata, 20g of Imperata cylindrica, 10g of Pollen Typhae, 10g of Radix Sanguisorbae charcoal, 20g of Astragalus and 5g of Panax notoginseng powder are mixed by weight to obtain a mixed medicinal material. Then the mixed medicinal material is crushed into fine powder to obtain a medicinal material powder; wherein the crushing particle size is 100 to 300 meshes. Then the medicinal material powder is mixed with petrolatum in a ratio of 1:1, and a paste is formed after complete fusion. Finally, the paste is filled into a container to prepare a finished nasal ointment; wherein the container is one of a plastic tube body and an aluminum tube body. The finished nasal ointment can be used for the treatment of sinusitis, and the uniformity and standardization of the ingredients are ensured by modern preparation methods, thereby improving the treatment effect, reducing side effects, and adapting to the needs of the modern medical system, which helps to improve the quality of life of patients with sinusitis and provides a safe and effective treatment option.

[0035] Example 2, please refer to Figure 2 The present invention provides a method for preparing a Chinese medicine nose ointment for treating sinusitis, comprising the following steps:

[0036] S201: Mix 20 g of Scutellaria baicalensis, 30 g of Coptidis rhizome, 20 g of Phellodendron chinense, 30 g of Gardenia charcoal, 10 g of Rhubarb, 10 g of Bletilla striata, 30 g of Imperata cylindrica, 20 g of Pollen Typhae, 20 g of Sanguisorba officinalis charcoal, 30 g of Astragalus membranaceus and 10 g of Panax notoginseng powder, by weight, to obtain a mixed medicinal material;

[0037] S202: Grinding the mixed medicinal materials into fine powder to obtain medicinal material powder;

[0038] S203: mixing the medicinal material powder and petrolatum in a ratio of 1:1 to form a paste after they are completely blended;

[0039] S204: Filling the paste into a container to prepare a finished nasal paste.

[0040] In this embodiment, by first mixing 20g of Scutellaria baicalensis, 30g of Coptis chinensis, 20g of Phellodendron chinense, 30g of Gardenia charcoal, 10g of Rhubarb, 10g of Bletilla striata, 30g of Imperata cylindrica, 20g of Pollen Typhae, 20g of Radix Sanguisorbae charcoal, 30g of Astragalus and 10g of Panax notoginseng powder by weight, a mixed medicinal material is obtained. Then the mixed medicinal material is crushed into fine powder to obtain a medicinal powder; wherein the crushing particle size is 100 to 300 meshes. Then the medicinal powder is mixed with petrolatum in a ratio of 1:1, and a paste is formed after complete fusion. Finally, the paste is filled into a container to prepare a finished nasal ointment; wherein the container is one of a plastic tube body and an aluminum tube body. The finished nasal ointment can be used for the treatment of sinusitis, and the uniformity and standardization of the ingredients are ensured by modern preparation methods, thereby improving the treatment effect, reducing side effects, and adapting to the needs of the modern medical system, which helps to improve the quality of life of patients with sinusitis and provides a safe and effective treatment option.

[0041] Example 3, please refer to Figure 3 The present invention provides a method for preparing a Chinese medicine nose ointment for treating sinusitis, comprising the following steps:

[0042] S301: Mix 30 g of Scutellaria baicalensis, 40 g of Coptidis rhizome, 30 g of Phellodendron chinense, 40 g of Gardenia charcoal, 15 g of Rhubarb, 15 g of Bletilla striata, 40 g of Imperata cylindrica, 30 g of Pollen Typhae, 30 g of Sanguisorba officinalis charcoal, 40 g of Astragalus membranaceus and 15 g of Panax notoginseng powder, by weight, to obtain a mixed medicinal material;

[0043] S302: Grinding the mixed medicinal materials into fine powder to obtain medicinal material powder;

[0044] S303: mixing the medicinal material powder and petrolatum in a ratio of 1:1, and forming a paste after they are completely blended;

[0045] S304: Filling the paste into a container to prepare a finished nose paste.

[0046] In this embodiment, 30g of Scutellaria baicalensis, 40g of Coptis chinensis, 30g of Phellodendron chinense, 40g of Gardenia charcoal, 15g of Rhubarb, 15g of Bletilla striata, 40g of Imperata cylindrica, 30g of Pollen Typhae, 30g of Radix Sanguisorbae Carbon, 40g of Astragalus and 15g of Panax notoginseng powder are mixed by weight to obtain a mixed medicinal material. Then the mixed medicinal material is crushed into fine powder to obtain a medicinal material powder; wherein the crushing particle size is 100 to 300 meshes. Then the medicinal material powder is mixed with petrolatum in a ratio of 1:1, and a paste is formed after complete fusion. Finally, the paste is filled into a container to prepare a finished nasal ointment; wherein the container is one of a plastic tube body and an aluminum tube body. The finished nasal ointment can be used for the treatment of sinusitis, and the uniformity and standardization of the ingredients are ensured by modern preparation methods, thereby improving the treatment effect, reducing side effects, and adapting to the needs of the modern medical system, which helps to improve the quality of life of patients with sinusitis and provides a safe and effective treatment option.

[0047] Example 4

[0048] The therapeutic effect of the Chinese medicine nasal ointment prepared in Test Examples 1 to 3 on the acute sinusitis model:

[0049] Fifty healthy male Wistar rats were selected, each weighing 180±10g. They were randomly divided into 5 groups, marked as dosing group A, dosing group B, dosing group C, blank group and model group. After one week of adaptive feeding of rats in each group, 0.1ml of 5% copper sulfate solution was dripped into the nasal cavity of the rats once a day for 3 consecutive days to establish an acute sinusitis model.

[0050] After the model was established, the Chinese medicine nasal ointment prepared in Example 1 was used for the measurement of group A, the Chinese medicine nasal ointment prepared in Example 2 was used for the measurement of group B, and the Chinese medicine nasal ointment prepared in Example 3 was used for the measurement of group C, and normal saline was used for the blank group. The nasal cavity of each group of rats was sprayed with 1 ml each time for 7 consecutive days, and they were kept in a normal manner during this period.

[0051] After 7 days of treatment, the relief of sinusitis symptoms in each group of rats was observed and recorded, including the improvement of nasal congestion, sneezing, runny nose and other symptoms. The rats were killed, and the nasal cavity was measured for inflammatory factors by PCR to observe the sinus inflammation.

[0052] Depend on Figure 1 It can be seen that in the acute sinusitis model, the Chinese medicine nasal ointment group A, the Chinese medicine nasal ointment group B and the Chinese medicine nasal ointment group C can effectively inhibit the inflammation level of the nasal cavity (P < 0.05), and have a dose-dependent relationship. It shows that the Chinese medicine nasal ointment prepared in Examples 1 to 3 has a protective effect on acute sinusitis.

[0053] Example 5

[0054] The in vitro antibacterial effect of the Chinese medicine nasal ointment prepared in test examples 1 to 3:

[0055] Take the ATCC standard strain with a bacterial age of 16 to 24 hours and dilute it to 1*10^6CFU / ml with casein beef broth. Take a 96-well sterilized culture plate, set 12*3 wells for each strain, the first well is a negative control well (original concentration of Example 1, Example 2, Example 3 Chinese medicine nose ointment, no bacteria), the 12th well is a positive control well (no medicine), use a pipette to add 50μl of bacteria-containing casein beef broth culture medium to each well from the 2nd to the 12th well, and make 3 rows for each strain to reduce experimental errors. ③ Add 50μl of original concentration of each example Chinese medicine nose ointment to the 1st and 2nd wells respectively, mix the 2nd well, then draw 50μl of the mixture from the 2nd well to the 3rd well, and then draw 50μl to the 4th well after mixing, and so on and so forth to dilute continuously to the 11th well, and draw 50μl of the mixture from the 11th well and discard it. At this time, the dilution multiples of each example of Chinese herbal nasal ointment in each well from 1 to 12 are 1 times, 2 times, 4 times, 8 times, ..., 1024 times, and 0 times, respectively. After covering, place in a 37°C constant temperature incubator for incubation for 24 hours and then take out. Use turbidimetry to preliminarily evaluate the bacterial growth in each well with the naked eye. In the biological safety cabinet, take Haemophilus chocolate agar selective medium to culture Haemophilus influenzae and Moraxella catarrhalis in each well, and Columbia blood agar medium to culture the other 9 bacteria in each well. Incubate in a 37°C constant temperature incubator for 24 hours to 48 hours, then take out and observe whether there is bacterial growth on the culture medium to determine the in vitro inhibitory concentration of each example of Chinese herbal nasal ointment against common pathogens. The minimum inhibitory concentration (MIC) is the lowest drug concentration at which there is no bacterial growth in the small well and on the corresponding culture medium. The experiment is meaningful only when there is obvious bacterial growth in the positive control well (well 12). The bacterial inhibition effect is shown in Table 1

[0056]

[0057]

[0058] Table 1

[0059] As can be seen from Table 1, * indicates that the Chinese herbal nasal ointment has no antibacterial effect on the bacteria, and the Chinese herbal nasal ointments prepared in Examples 1 to 3 have good inhibitory effects on most bacteria.

[0060] Example 6

[0061] The therapeutic effect of the Chinese medicine nasal ointment prepared in Test Examples 1 to 3 on the chronic sinusitis model:

[0062] Fifty healthy male C57BL / 6 mice were selected, each weighing 20±2g. They were randomly divided into 5 groups, marked as dosing group A, dosing group B, dosing group C, blank group and model group. After one week of adaptive feeding of mice in each group, 0.05ml of 10% ovalbumin solution was dripped into the nasal cavity of the mice once a day for 10 consecutive days to establish a chronic sinusitis model.

[0063] After the model was established, the Chinese medicine nasal ointment prepared in Example 1 was used for group A, the Chinese medicine nasal ointment prepared in Example 2 was used for group B, and the Chinese medicine nasal ointment prepared in Example 3 was used for group C. Physiological saline was used for the blank group, and the model group was not treated in any way. The nasal cavity of each group of mice was sprayed with 0.1 ml each time for 14 consecutive days, and they were kept in a conventional manner during this period.

[0064] After 14 days of treatment, the relief of sinusitis symptoms in each group of mice was observed and recorded, including the improvement of symptoms such as nasal congestion, sneezing, and runny nose. The mice were killed, and nasal tissues were taken for the determination of inflammatory factors such as IL-6. The sinus inflammation was observed by PCR.

[0065] Depend on Figure 2 It can be seen that in the chronic sinusitis model, the Chinese medicine nose ointment group A, the Chinese medicine nose ointment group B and the Chinese medicine nose ointment group C can effectively inhibit the inflammation level of the nasal cavity (P < 0.05), and there is a dose-dependent relationship. These evidences show that the Chinese medicine nose ointment prepared in Examples 1 to 3 has a protective effect on chronic sinusitis.

[0066] What is disclosed above is only a preferred embodiment of the present invention, and it certainly cannot be used to limit the scope of rights of the present invention. Ordinary technicians in this field can understand that all or part of the processes of the above embodiment and equivalent changes made according to the claims of the present invention still fall within the scope of the invention.

Claims

1. A Chinese medicine nose ointment for treating sinusitis, characterized in that: The method is prepared by comprising the following raw materials in parts by weight: Scutellaria baicalensis 10-30g, Coptis chinensis 20-40g, Phellodendron amurense 10-30g, Gardenia charcoal 20-40g, Rhubarb 5-15g, Bletilla striata 5-15g, Imperata cylindrica 20-40g, Pollen Typhae 10-30g, Sanguisorba officinalis charcoal 10-30g, Astragalus 20-40g, Panax notoginseng powder 5-15g.

2. A method for preparing a Chinese medicine nasal ointment for treating sinusitis, comprising preparing the Chinese medicine nasal ointment for treating sinusitis as claimed in claim 1, characterized in that: The steps include: Mix scutellaria baicalensis, coptis chinensis, phellodendron amurense, gardenia charcoal, rhubarb, bletilla striata, imperata root, pollen cattail, sanguisorba officinalis charcoal, astragalus and notoginseng powder according to parts by mass to obtain a mixed medicinal material; Grinding the mixed medicinal materials into fine powder to obtain medicinal material powder; Mixing the medicinal material powder with a carrier material to form a paste; The paste is filled into a container to prepare a finished nose paste.

3. The method for preparing the Chinese medicine nose ointment for treating sinusitis according to claim 2, characterized in that: In the step of crushing the mixed medicinal materials into fine powder to obtain medicinal material powder: The crushing particle size is 100-300 mesh.

4. The method for preparing the Chinese medicine nose ointment for treating sinusitis according to claim 2, characterized in that: In the step of mixing the medicinal material powder with the carrier material to form a paste: The carrier material is one of petrolatum and gel.

5. The method for preparing the Chinese medicine nose ointment for treating sinusitis according to claim 2, characterized in that: In the step of filling the paste into a container to prepare a finished nose paste: The container is one of a plastic tube body and an aluminum tube body.

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