A composition for improving skin acne, inflammation and a method of preparing the same

Abstract

The present application belongs to the technical field of cosmetics, and particularly relates to a composition for improving skin acne and inflammation and a preparation method thereof, raw materials of which include sophora extract, liquorice extract, honeysuckle extract, loquat leaf extract, gastrodia tuber extract, schisandra stem extract and stabilizer in a weight ratio of (3-5):(0.5-1):(1-2):(2-3):(3-5):(2-4):(1.5-2.5). The stabilizer comprises stabilizer I and stabilizer II in a mass ratio of 1:(2-3). The stabilizer I is silver-doped titanium dioxide nanomaterial, and the stabilizer II comprises one or more of evening primrose seed oil, alginate and guar gum. The composition for improving skin acne and inflammation prepared by the present application not only has a significant effect of improving skin acne and inflammation, but also has small side effects and high safety.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a composition for improving skin acne and inflammation, and its preparation method. Background Technology

[0002] With the fast pace of life and changes in the living environment, skin problems are becoming increasingly prominent, especially acne and inflammation, which have become health issues troubling many people. Acne and inflammation are often related to a variety of factors such as excessive sebum secretion, clogged pores, and bacterial infection, causing great physical and psychological stress for patients.

[0003] Currently, there are numerous products on the market targeting acne and inflammation, but most have limited effectiveness and may even have side effects. Some products primarily improve skin condition by inhibiting sebum secretion or having antibacterial effects, but long-term use may damage the skin barrier, making the skin more sensitive. Furthermore, while some products may provide short-term relief, they are prone to causing recurring acne and do not address the root cause of the problem.

[0004] With the development of biomedicine and medicinal chemistry, more and more researchers are focusing on the application of natural plant extracts in skin care. Natural plant extracts typically contain multiple active ingredients that can comprehensively regulate skin condition with fewer side effects. Therefore, using natural plant extracts to prepare compositions that improve skin acne and inflammation is an important direction in current technological development.

[0005] Meanwhile, with the development of nanotechnology, its application in skin care products has become a new research hotspot. Nanotechnology can improve the permeability and stability of products, allowing active ingredients to function more effectively. Therefore, combining nanotechnology with natural plant extracts to prepare highly effective and safe compositions for improving acne and inflammation has broad application prospects.

[0006] Therefore, developing a novel composition and its preparation method for improving acne and inflammation is not only of significant practical importance but also aligns with current technological trends. Through in-depth research and practice, we hope to make new contributions to the development of the skin care field. Summary of the Invention

[0007] The purpose of this invention is to provide a composition for improving skin acne and inflammation, and a method for preparing the same. The composition prepared by this invention not only has a significant effect on improving skin acne and inflammation, but also has few side effects and high safety.

[0008] On one hand, the present invention provides a composition for improving skin acne and inflammation, the raw materials of which include Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract and stabilizer in a weight ratio of (3-5):(0.2-0.4):(1-2):(2-3):(3-5):(2-4):(1.5-2.5).

[0009] Furthermore, the stabilizer comprises stabilizer one and stabilizer two in a mass ratio of 1:(2-3); stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two comprises one or more of evening primrose seed oil, alginate and guar gum.

[0010] Furthermore, the preparation method of the silver-doped titanium dioxide nanomaterial includes: mixing AgNO3 and P25 titanium dioxide nanopowder in a mass ratio of (1-2):100 evenly, placing them in a muffle furnace for calcination for 3-5 hours at a calcination temperature of 600-800℃, to obtain silver-doped titanium dioxide nanomaterial Ag / TiO2.

[0011] Furthermore, the second stabilizer is evening primrose seed oil, alginate, and guar gum in a weight ratio of (4-8):(2-3):(1-3).

[0012] Furthermore, the composition also includes a humectant in 40-50% by weight relative to the stabilizer.

[0013] Furthermore, the moisturizer comprises glycerin and vitamin B5 in a weight ratio of 1:(1-2).

[0014] On the other hand, the present invention also provides a method for preparing a composition for improving skin acne and inflammation, the steps of which include:

[0015] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica leaf, Gastrodia elata tuber and Schisandra chinensis vine stem, wash them with water and dry them to constant weight, pulverize them and extract them with water, filter them and collect the filtrate;

[0016] (2) After adding stabilizer one to the filtrate, sonicate for 30-40 min, and then perform vacuum distillation and low-temperature drying on the sonicated filtrate to obtain the mixed extract;

[0017] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 30-35℃ to obtain a composition that improves skin acne and inflammation.

[0018] Furthermore, the water extraction process uses a material-to-liquid ratio of 1:(20-25), an extraction temperature of 60-80℃, and an extraction time of 60-80 min; the low-temperature drying is performed at 40-45℃.

[0019] On the other hand, the present invention also provides the application of compositions for improving skin acne and inflammation as skin care product additives.

[0020] Furthermore, the skincare products include any one of toners, lotions, serums, creams, gels, masks, gels, and lotions.

[0021] The polyphenolic compounds in Sophora flavescens extract have the ability to scavenge free radicals and reduce oxidative damage, thus exerting a good antioxidant effect. This helps reduce free radical damage to the skin and is beneficial to skin health.

[0022] Licorice extract is a traditional Chinese medicine with various pharmacological effects. Its main components include glycyrrhizic acid, which has anti-inflammatory, anti-allergic, hepatoprotective, antiviral, immunomodulatory, and anti-shock effects. Licorice extract is considered to have the effects of tonifying the spleen and replenishing qi, relieving phlegm and cough, alleviating pain, clearing heat and detoxifying. It can be used to treat symptoms such as weakness, cough with excessive phlegm, stomach pain, abdominal pain, and diarrhea, as well as to alleviate the toxicity of other medications.

[0023] Honeysuckle extract has inhibitory effects on various pathogens, including Salmonella typhi, Salmonella paratyphi, Escherichia coli, and Proteus. This allows it to exert anti-inflammatory and antibacterial effects in the treatment of skin diseases, oral ulcers, and other ailments. Furthermore, honeysuckle extract can be used in decoctions for internal administration or as suppositories for external application. When used with other traditional Chinese medicines such as Forsythia suspensa, Coptis chinensis, and Phellodendron chinense, it can have the effects of clearing heat and detoxifying, reducing swelling, and relieving pain.

[0024] Loquat leaf extract exhibits inhibitory effects against various bacteria, including Staphylococcus aureus, Staphylococcus epidermidis, hemolytic streptococci, Streptococcus pneumoniae, and Moraxella catarrhalis. Its ethyl acetate and ethanol extracts show significant antibacterial effects against these bacteria. Furthermore, components such as ursolic acid in loquat leaf extract possess significant anti-inflammatory properties, reducing inflammatory responses. Loquat leaf extract is rich in antioxidants, capable of scavenging free radicals and reducing oxidative damage, thus playing a positive role in maintaining skin health and delaying aging.

[0025] Gastrodia elata tuber extract has a significant sedative effect. Vanillin (3-methoxy-4-hydroxybenzaldehyde) and p-hydroxybenzyl alcohol in it are effective scavengers of hydroxyl and peroxide free radicals, which can inhibit lipid peroxidation, thus exerting an anticonvulsant effect. In addition, Gastrodia elata tuber extract is also used to treat symptoms such as headache, dizziness, infantile convulsions, epileptic seizures, and tetanus.

[0026] Schisandra chinensis extract has antioxidant, immune-regulating, anti-tumor, nervous system-protective, liver-detoxifying, and liver-protective effects. The active ingredients, amino acids, and trace elements in the schisandra vine stems nourish delicate skin and enhance its antioxidant capacity. Furthermore, total lignans from schisandra chinensis can reduce inflammation caused by Propionibacterium acnes and inhibit the release of related inflammatory factors.

[0027] The beneficial effects of this invention are as follows:

[0028] (1) The preparation method of the composition for improving skin acne and inflammation described in this invention, through steps such as extraction of natural plant extracts, nano-processing, and mixing and molding, yields a product with significant therapeutic effects and high safety. This preparation method not only fully utilizes the medicinal value of natural plants, but also improves the permeability and stability of the product through the application of nanotechnology.

[0029] (2) In this invention, Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, and Schisandra chinensis vine stem extract are combined to produce a synergistic effect by utilizing their respective anti-inflammatory effects, which can effectively inhibit inflammatory responses. Among them, Sophora flavescens extract and Glycyrrhiza uralensis extract have particularly significant anti-inflammatory effects, which can inhibit the growth of various bacteria and viruses and have a positive effect on antibacterial and anti-inflammatory effects. In addition, these extracts also have antioxidant effects, which can scavenge free radicals, reduce oxidative damage, and protect cells from damage. Among them, Lonicera japonica extract and Schisandra chinensis vine stem extract are outstanding in this regard, which can enhance the antioxidant capacity of the skin surface and delay skin aging.

[0030] (3) The Gastrodia elata tuber extract in this invention is rich in various active ingredients, such as gastrodin and polysaccharides, which have anti-inflammatory, antioxidant and immunomodulatory functions; while the Schisandra chinensis vine stem extract contains compounds such as schisandrol A, which have significant antibacterial, anti-inflammatory and antioxidant effects. When the two are combined, they can work together to target multiple aspects of skin acne and inflammation, thereby enhancing the therapeutic effect. The Gastrodia elata tuber extract and the Schisandra chinensis vine stem extract each have unique pharmacological effects, and when the two are combined, they can exert a synergistic effect.

[0031] (4) The present invention uses silver-doped titanium dioxide nanomaterials, evening primrose seed oil, alginate and guar gum as compound stabilizers, combining the natural stability properties of evening primrose seed oil, alginate and guar gum with the nanoscale characteristics of silver-doped titanium dioxide nanomaterials, making the whole system more stable; these components can work together to form a stable colloidal structure, preventing the product from layering, precipitation or phase separation, thereby ensuring the long-term stability of the product.

[0032] (5) In this invention, silver-doped titanium dioxide nanomaterials are used as the substrate material for loading active extracts, that is, as a stabilizer. First, silver has excellent antibacterial ability and can effectively kill a variety of bacteria. When silver ions are loaded on titanium dioxide nanomaterials, the antibacterial effect of silver can be further enhanced. Silver ions can penetrate the bacterial cell wall, act on the proteins in the bacterial body, inhibit their synthesis, change their structure, thereby affecting the normal growth process and energy transfer process of the bacteria, and ultimately leading to bacterial death. This antibacterial property is particularly important for improving skin acne and inflammation, because it can directly reduce the number of bacteria on the skin surface, thereby reducing the risk of inflammation and infection. Secondly, after silver ions are loaded on the titanium dioxide matrix, the silver nanoparticles can be embedded in the defects of titanium dioxide crystals, which to a certain extent plays the role of dispersing silver and can regulate the silver content and the size of silver particles. This allows silver ions to be slowly released from the composite material, thereby ensuring that the antibacterial property of the material will not decrease or disappear over time during use. This long-lasting antibacterial property is particularly important for improving skin problems, because it can ensure that the antibacterial effect can be sustained, thereby effectively improving skin acne and inflammation. In addition, compared with traditional antibacterial agents, silver-doped titanium dioxide nanomaterials have advantages in terms of safety. Because its antibacterial mechanism is to kill bacteria directly through physical and chemical action, rather than inhibiting bacterial growth by producing toxic substances, it is less irritating to human skin. Moreover, the small size of nanomaterials makes it easier to penetrate into the deeper layers of the skin and exert better effects.

[0033] (6) This invention involves nano-processing of the active extract to transform the active ingredients in the extract into nano-sized particles with smaller particle size and larger specific surface area, thereby improving their permeability and stability on the skin. This step not only helps the active ingredients better penetrate the skin barrier and act deeply on the deep skin tissue, but also ensures the sustained release of the active ingredients on the skin surface, thus exerting a sustained therapeutic effect, thereby preparing a highly effective, safe, and stable composition product for improving acne and inflammation. Detailed Implementation

[0034] The technical solution of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0035] Example 1

[0036] This embodiment provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, and a stabilizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2.

[0037] The stabilizer includes stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil, alginate and guar gum in a weight ratio of 6:2.5:2.

[0038] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0039] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0040] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0041] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0042] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0043] Example 2

[0044] This embodiment provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, and a stabilizer in a weight ratio of 3:0.5:1:2:3:2:1.5.

[0045] The stabilizer includes stabilizer one and stabilizer two in a mass ratio of 1:2; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil, alginate and guar gum in a weight ratio of 4:2:1.

[0046] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1:100, calcining it in a muffle furnace for 3 hours at a calcination temperature of 800℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0047] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0048] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica leaf, Gastrodia elata tuber and Schisandra chinensis vine stem, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:20, the extraction temperature is 60℃ and the extraction time is 60min.

[0049] (2) After adding stabilizer one to the filtrate, sonicate for 30 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 40℃ to obtain the mixed extract;

[0050] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 30°C to obtain a composition that improves skin acne and inflammation.

[0051] Example 3

[0052] This embodiment provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, and a stabilizer in a weight ratio of 5:1:2:3:4:4:2.5.

[0053] The stabilizer includes stabilizer one and stabilizer two in a mass ratio of 1:3; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil, alginate and guar gum in a weight ratio of 8:3:3.

[0054] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 2:100, calcining it in a muffle furnace for 5 hours at a calcination temperature of 800℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0055] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0056] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica leaf, Gastrodia elata tuber and Schisandra chinensis vine stem, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of material to liquid in the water extraction process is 1:25, the extraction temperature is 80℃ and the extraction time is 80min.

[0057] (2) After adding stabilizer one to the filtrate, sonicate for 40 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 45°C to obtain the mixed extract;

[0058] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 35°C to obtain a composition that improves skin acne and inflammation.

[0059] Example 4

[0060] This embodiment provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, stabilizer, and moisturizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2:1.

[0061] The stabilizer comprises stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil, alginate, and guar gum in a weight ratio of 6:2.5:2; the moisturizer is glycerin and vitamin B5 in a weight ratio of 1:1.5.

[0062] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0063] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0064] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0065] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0066] (3) Add stabilizer II and moisturizer to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0067] Example 5

[0068] This embodiment provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, stabilizer, and moisturizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2:1.

[0069] The stabilizer comprises stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil, alginate, and guar gum in a weight ratio of 6:2.5:2; the humectant is glycerin.

[0070] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0071] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0072] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0073] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0074] (3) Add stabilizer II and moisturizer to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0075] Example 6

[0076] This embodiment provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, stabilizer, and moisturizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2:1.

[0077] The stabilizer comprises stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil, alginate, and guar gum in a weight ratio of 6:2.5:2; the moisturizer is vitamin B5.

[0078] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0079] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0080] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0081] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0082] (3) Add stabilizer II and moisturizer to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0083] Example 7

[0084] This embodiment provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, and a stabilizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2.

[0085] The stabilizer includes stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil and guar gum in a weight ratio of 3:1.

[0086] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0087] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0088] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0089] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0090] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0091] Example 8

[0092] This embodiment provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, and a stabilizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2.

[0093] The stabilizer includes stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil and alginate in a weight ratio of 6:2.5.

[0094] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0095] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0096] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0097] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0098] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0099] Comparative Example 1

[0100] This comparative example provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Schisandra chinensis stem extract, and a stabilizer in a weight ratio of 4:0.7:1.5:2.5:3:2.

[0101] The stabilizer includes stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil, alginate and guar gum in a weight ratio of 6:2.5:2.

[0102] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0103] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0104] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0105] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0106] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0107] Comparative Example 2

[0108] This comparative example provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, and a stabilizer in a weight ratio of 4:0.7:1.5:2.5:4:2.

[0109] The stabilizer includes stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil, alginate and guar gum in a weight ratio of 6:2.5:2.

[0110] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0111] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0112] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0113] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0114] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0115] Comparative Example 3

[0116] This comparative example provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, and a stabilizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2.

[0117] The stabilizer comprises stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil;

[0118] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0119] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0120] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0121] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0122] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0123] Comparative Example 4

[0124] This comparative example provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, and a stabilizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2.

[0125] The stabilizer comprises stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is guar gum;

[0126] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0127] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0128] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0129] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0130] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0131] Comparative Example 5

[0132] This comparative example provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, and a stabilizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2.

[0133] The stabilizer comprises stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is alginate.

[0134] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0135] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0136] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0137] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0138] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0139] Comparative Example 6

[0140] This comparative example provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, and a stabilizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2.

[0141] The stabilizer includes stabilizer one and stabilizer two in a mass ratio of 1:2.5; stabilizer one is titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil, alginate and guar gum in a weight ratio of 6:2.5:2.

[0142] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0143] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0144] (2) After adding stabilizer one to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at low temperature at 42℃ to obtain the mixed extract;

[0145] (3) Add stabilizer II to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0146] Comparative Example 7

[0147] This comparative example provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, and a stabilizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2.

[0148] The stabilizer is silver-doped titanium dioxide nanomaterial;

[0149] The preparation method of silver-doped titanium dioxide nanomaterials includes: mixing AgNO3 with P25 titanium dioxide nanopowder at a mass ratio of 1.5:100 evenly, placing it in a muffle furnace and calcining for 4 hours at a calcination temperature of 700℃ to obtain silver-doped titanium dioxide nanomaterials Ag / TiO2.

[0150] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0151] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0152] (2) After adding a stabilizer to the filtrate, sonicate for 35 min, then distill the sonicated filtrate under reduced pressure and dry it at 42°C to obtain a mixed extract.

[0153] (3) The mixture of extracts is stirred and mixed evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0154] Comparative Example 8

[0155] This comparative example provides a composition for improving skin acne and inflammation, comprising Sophora flavescens extract, Glycyrrhiza uralensis extract, Lonicera japonica extract, Eriobotrya japonica leaf extract, Gastrodia elata tuber extract, Schisandra chinensis vine stem extract, and a stabilizer in a weight ratio of 4:0.7:1.5:2.5:4:3:2.

[0156] The stabilizer is evening primrose seed oil, alginate, and guar gum in a weight ratio of 6:2.5:2.

[0157] The method for preparing this composition for improving skin acne and inflammation includes the following steps:

[0158] (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber and Schisandra chinensis vine, wash them with water, dry them at 60℃ to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; wherein, the ratio of raw material to liquid in the water extraction process is 1:22, the extraction temperature is 70℃ and the extraction time is 70min.

[0159] (2) The filtrate was subjected to vacuum distillation and then dried at a low temperature of 42°C to obtain a mixed extract;

[0160] (3) Add a stabilizer to the mixed extract and stir and mix evenly at 32°C to obtain a composition that improves skin acne and inflammation.

[0161] Experimental Example: The properties of the compositions for improving skin acne and inflammation prepared in Examples 1-8 and Comparative Examples 1-8 were investigated. The compositions for improving skin acne and inflammation were tested as follows:

[0162] Test 1: Antibacterial Test

[0163] To verify the antibacterial effect of the compositions described in this invention, the antibacterial properties of the compositions for improving skin acne and inflammation described in Examples 1-8 and Comparative Examples 1-8 of this invention were tested according to Appendix C4 "Test Method for Antibacterial Performance of Dissolution Antibacterial (Inhibitory) Products" of GB15979-2002 "Hygienic Standard for Disposable Sanitary Products".

[0164] (1) Test sample: The test sample is prepared by adding the composition obtained in the examples and comparative examples to the emulsion external matrix, and the composition accounts for 2% of the total mass of the emulsion.

[0165] (2) Preparation of bacterial suspension: Take 24h culture of Propionibacterium acnes and wash it with 0.03mol / L phosphate buffer to prepare 10 4 ~10 6 CFU / mL bacterial suspension.

[0166] (3) Take 1g of the test sample, add 0.1mL of the above bacterial suspension, spread and mix evenly, start timing, and after 20min, add 9mL of 0.03mol / L phosphate buffer and mix thoroughly. After appropriate dilution, take 1mL of each of the three dilutions and place it in two parallel petri dishes. Then add the corresponding culture medium and incubate under anaerobic conditions at 36±1℃ for 24 hours, and count the colonies. Repeat the above experiment 3 times, take the average, and set up a blank control group.

[0167] The formula for calculating the inhibition rate is: X = (AB) / A × 100%, where X is the inhibition rate, A is the average recovered colonies of the control sample, and B is the average recovered colonies of the test sample.

[0168] The efficacy evaluation criteria are as follows: (1) an antibacterial rate of ≥90% is considered effective; (2) an antibacterial rate of 50-90% is considered effective; and (3) an antibacterial rate of <50% is considered ineffective.

[0169] The antibacterial efficacy test results of the emulsions prepared from the compositions of Examples 1-8 and Comparative Examples 1-8 are shown in Table 1.

[0170] Table 1 Antibacterial test results

[0171]

[0172] Test 2: Stability Test

[0173] Test samples: The experimental group consisted of compositions prepared in the examples and comparative examples; the control group consisted of compositions prepared in the examples and comparative examples without temperature testing and stored at room temperature.

[0174] 1. Heat resistance test

[0175] The heat resistance test involved placing each test sample at room temperature directly into an oven at 40±1℃ for 24 hours. After returning to room temperature, the test samples were observed to see if there was any significant difference between them and the control group. The results are shown in Table 2.

[0176] 2. Cold resistance test

[0177] The cold resistance test involved placing each test sample, which was at room temperature, directly into a -10°C low-temperature chamber for 24 hours. After returning to room temperature, the test samples were observed to see if there was any significant difference between them and the control group. The results are shown in Table 2.

[0178] Table 2. Stability test results of the compositions of the present invention

[0179]

[0180] Test 3: Volunteer test data

[0181] (1) Test sample: The sample from Test 1 is still used;

[0182] (2) Test subjects: 160 people, aged 18-30, all with oily or combination skin, and no history of skin diseases or skin allergies;

[0183] (3) Testing method: The test subjects were randomly divided into 16 groups (10 people in each group), and each group applied a different test sample. The subjects used the test sample once in the morning and once in the evening for 28 consecutive days. Before use and after 28 days of use, the forehead area was tested 3 times with a skin oil test probe (Sebumeter, CK, Germany), and the average value was taken to evaluate the oil control effect of the composition for improving skin acne and inflammation provided by the present invention;

[0184] (4) Evaluation criteria: Significant effect is defined as a significant reduction in facial oil secretion and the basic elimination of acne; Effective effect is defined as a reduction in facial oil secretion and the partial elimination of acne; Ineffective effect is defined as no significant change in facial oil secretion and no or only slight reduction in acne. The experimental results are shown in Table 3.

[0185] Table 3 Results of Human Trial Testing

[0186]

[0187] The aforementioned composition for improving skin acne and inflammation is used as an additive in skin care products, which include any one of toners, lotions, serums, creams, gels, masks, gels, and lotions.

[0188] Finally, it should be noted that the above embodiments are only used to illustrate the present invention and are not intended to limit the technical solutions described in the present invention; those skilled in the art should understand that modifications or equivalent substitutions can still be made to the present invention; and all technical solutions and improvements that do not depart from the spirit and scope of the present invention should be covered within the scope of the claims of the present invention.

Claims

1. A composition for improving skin acne and inflammation, characterized in that, The raw materials include extracts of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica, Gastrodia elata tuber, and Schisandra chinensis vine stem, in a weight ratio of (3-5):(0.5-1):(1-2):(2-3):(3-5):(2-4):(1.5-2.5), and stabilizers; wherein the stabilizers include stabilizer one and stabilizer two in a weight ratio of 1:(2-3); stabilizer one is silver-doped titanium dioxide nanomaterial, and stabilizer two is evening primrose seed oil, alginate, and guar gum in a weight ratio of (4-8):(2-3):(1-3).

2. The composition for improving skin acne and inflammation according to claim 1, characterized in that, The preparation method of the silver-doped titanium dioxide nanomaterial includes: mixing AgNO3 with P25 titanium dioxide nanopowder in a mass ratio of (1-2):100 evenly, placing it in a muffle furnace for calcination for 3-5 hours at a calcination temperature of 600-800℃, to obtain silver-doped titanium dioxide nanomaterial Ag / TiO2.

3. The composition for improving skin acne and inflammation according to claim 1, characterized in that, The composition also includes a humectant in 40-50% by weight relative to the stabilizer.

4. The composition for improving skin acne and inflammation according to claim 3, characterized in that, The moisturizer comprises glycerin and vitamin B5 in a weight ratio of 1:(1-2).

5. A method for preparing a composition for improving skin acne and inflammation as described in claim 1, characterized in that the step... include: (1) Weigh out the raw materials of Sophora flavescens, Glycyrrhiza uralensis, Lonicera japonica, Eriobotrya japonica leaf, Gastrodia elata tuber and Schisandra chinensis vine stem, wash them with water and dry them to constant weight, pulverize them and extract them with water, filter them and collect the filtrate; (2) After adding stabilizer one to the filtrate, sonicate for 30-40 min, and then perform vacuum distillation and low-temperature drying on the sonicated filtrate to obtain the mixed extract; (3) Add stabilizer II to the mixed extract and stir and mix evenly at 30-35℃ to obtain a composition that improves skin acne and inflammation.

6. The method for preparing the composition for improving skin acne and inflammation according to claim 5, characterized in that, The water extraction process uses a material-liquid ratio of 1:(20-25), an extraction temperature of 60-80℃, and an extraction time of 60-80 min; the low-temperature drying is performed at 40-45℃.

7. The use of the composition for improving skin acne and inflammation according to any one of claims 1-4 in the preparation of skin care product additives.

8. The application according to claim 7, characterized in that, The skincare products include any one of toners, lotions, serums, creams, gels, masks, gels, and lotions.

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