A method for establishing a spleen deficiency and dampness accumulation model of bama mini-swine

By establishing a spleen deficiency and dampness syndrome model in Bama miniature pigs under high humidity, high sugar and high fat diet and cyclophosphamide stimulation, and verifying it with Shenling Baizhu Powder, the problem of lacking a spleen deficiency and dampness syndrome model in miniature pigs in the existing technology was solved, and the standardization and effectiveness of TCM drug research were realized.

CN118680120BActive Publication Date: 2026-06-26SOUTH CHINA AGRICULTURAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTH CHINA AGRICULTURAL UNIVERSITY
Filing Date
2024-06-04
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Currently, there is no universally accepted animal model for spleen deficiency and dampness syndrome, especially a miniature pig model, which affects TCM clinical diagnosis and drug development. Furthermore, rodents differ significantly from humans, making it difficult to observe clinical manifestations such as tongue appearance.

Method used

A spleen deficiency and dampness syndrome model was established by providing a high-humidity environment, a high-sugar and high-fat diet, and senna leaves to Bama miniature pigs, combined with intraperitoneal injection of cyclophosphamide, and the model was verified by using Shenling Baizhu powder.

Benefits of technology

A model of spleen deficiency and dampness excess in Bama miniature pigs, which conforms to the syndrome theory of traditional Chinese medicine, was established. This model can simulate the spleen deficiency and dampness excess syndrome in humans and can be used to study the development of spleen-strengthening and dampness-removing drugs. It is practical, scientific, and in line with the guidance of traditional Chinese medicine theory.

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Abstract

The application discloses a method for establishing a Bama miniature pig spleen deficiency and dampness excess model, and belongs to the technical field of animal models. The method is to reduce the immunity of the body by intraperitoneal injection of cyclophosphamide, and then to stimulate the Bama miniature pig by using high-sugar and high-fat feed and senna leaves in combination with a high-humidity external environment. After 8 weeks, the Bama miniature pig has the clinical manifestations of the spleen deficiency and dampness excess, such as body fatness, fatigue and laziness, white and slippery tongue fur, and loose and watery stool, and the model is verified in the reverse direction by using the classic compound Shenglin Bai Zhusan. The Bama miniature pig spleen deficiency and dampness excess model is applied to the research of human spleen deficiency and dampness excess and the development of spleen-invigorating and dampness-expelling drugs. The model provides a new model for standardizing, standardizing and scientifically evaluating the research of spleen-invigorating and dampness-expelling traditional Chinese medicines, and has the advantages of good practicability, strong conformity, simplicity and objectivity, and conforms to the guidance of the theory of traditional Chinese medicine syndromes, and has a wide application prospect.
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