A traditional Chinese medicine composition for treating peripheral neuritis and a preparation method and use thereof

Abstract

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating peripheral neuritis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from radix codonopsis, cortex phellodendri, chuanxiong rhizome, acanthopanax, radix puerariae, asarum, earthworm, honeysuckle and licorice. The traditional Chinese medicine composition has the effects of activating blood and removing blood stasis to dredge collaterals, benefiting qi and nourishing blood, and clearing heat and detoxifying, and is mainly used for treating peripheral neuritis patients of qi stagnation and blood stasis. Experimental results show that the traditional Chinese medicine composition can effectively improve the numbness, pain, paresthesia and other symptoms of peripheral neuritis patients, has a remarkable curative effect, and has no toxic and side effects.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating peripheral neuritis, its preparation method, and its uses. Background Technology

[0002] Peripheral neuritis, also known as peripheral neuritis or polyneuritis, is a dysfunction of the distal nerves of the limbs caused by various etiologies. The main manifestations of peripheral neuritis are sensory, motor, and autonomic nerve dysfunction within the area innervated by the affected nerve. Symptoms include decreased sensation, pain, numbness or tingling, tingling, burning, hyperesthesia, etc. Peripheral neuritis can be multiple or singular, symmetrical or asymmetrical, and is one of the most common diseases of the nervous system. Data shows that approximately 40% of patients with peripheral neuritis will experience sequelae, resulting in a high disability rate and severely impacting their physical and mental health and quality of life. Currently, there are few effective treatments for peripheral neuritis in clinical practice. High-dose B vitamins can be used to treat peripheral neuritis caused by various factors. Analgesics and sedatives are used for patients with significant pain. For inflammatory demyelinating lesions, corticosteroids such as prednisone, dexamethasone, or hydrocortisone can be used. However, these drugs often have high toxicity and side effects with long-term use, and complete cure is difficult to achieve.

[0003] Studies of traditional Chinese medicine (TCM) have shown that oral administration of herbal decoctions or prepared Chinese medicines, acupuncture, and massage can be effective for patients with peripheral neuritis. Although TCM does not have a specific record of "peripheral neuritis," based on its symptoms and disease progression, it falls under the categories of "Bi syndrome," "numbness," and "Wei syndrome" as recorded in TCM. The earliest records of all three can be traced back to the *Huangdi Neijing* (Yellow Emperor's Inner Classic). The terms Bi and Wei first appeared in the *Huangdi Neijing*. The *Suwen* (Plain Questions) section on Bi states that when wind, cold, and dampness linger in the muscles and bones, pain becomes unbearable; if the disease progresses for a long time, the flow of *ying* and *wei* (nutritive and defensive qi) becomes sluggish, and the skin is not nourished, resulting in numbness and insensitivity. The *Suwen* (Plain Questions) chapter on flaccid paralysis clearly records the etiology, pathogenesis, symptom classification, and treatment principles of flaccid paralysis. It points out that the main cause of flaccid paralysis is internal heat damaging body fluids, leading to malnourishment of the tendons and ligaments, resulting in flaccidity and weakness (see, for example, Wang Xiaomiao et al., "Research Progress in Traditional Chinese and Western Medicine on Polyneuritis," *Xinjiang Journal of Traditional Chinese Medicine*, Vol. 36, No. 5, 2018, pp. 141-144). Traditional Chinese medicine (TCM) is characterized by its syndrome differentiation and treatment, which can achieve good therapeutic effects for patients with peripheral nerve diseases of unknown cause and is less prone to recurrence, giving it a certain advantage over Western medicine. However, current research on TCM treatment is limited, and the types of TCM prescriptions and prepared medicines available are limited. Furthermore, the commonly used TCM methods for treating peripheral neuritis in clinical practice, such as acupuncture, electrotherapy, oral TCM decoctions, and external TCM washes, are complex and invasive, requiring treatment by professionals in hospitals, thus causing inconvenience to patients and resulting in poor treatment compliance.

[0004] In view of this, if a traditional Chinese medicine composition that is easy to prepare, inexpensive, effective, and free of toxic side effects can be developed for the treatment of peripheral neuritis, it will have greater clinical significance and social contribution to the treatment of this disease. Summary of the Invention

[0005] In order to overcome the problem of insufficient or ineffective drugs for treating peripheral neuritis in the existing technology, the present invention provides a traditional Chinese medicine composition for treating peripheral neuritis that is easy to prepare, low in cost, has significant efficacy, and has no toxic side effects, as well as its preparation method and uses.

[0006] Specifically, the present invention is achieved through the following technical solutions:

[0007] In a first aspect, the present invention provides a traditional Chinese medicine composition for treating peripheral neuritis, the composition being made from the following raw materials in parts by weight: Codonopsis pilosula 5-40 parts, Phellodendron chinense 5-40 parts, Ligusticum chuanxiong 5-40 parts, Acanthopanax senticosus 5-30 parts, Pueraria lobata 5-30 parts, Asarum heterotropoides 5-30 parts, Pheretima aspergillum 5-30 parts, Lonicera japonica 5-30 parts, and Glycyrrhiza uralensis 5-20 parts.

[0008] As an optional method, in the above-mentioned traditional Chinese medicine composition, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: Codonopsis pilosula 10-30 parts, Phellodendron chinense 10-30 parts, Ligusticum chuanxiong 10-30 parts, Acanthopanax senticosus 10-20 parts, Pueraria lobata 10-20 parts, Asarum heterotropoides 10-20 parts, Pheretima aspergillum 10-20 parts, Lonicera japonica 10-20 parts, and Glycyrrhiza uralensis 5-15 parts.

[0009] As an optional method, in the above-mentioned traditional Chinese medicine composition, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 20 parts of Codonopsis pilosula, 20 parts of Phellodendron chinense, 20 parts of Ligusticum chuanxiong, 20 parts of Acanthopanax senticosus, 15 parts of Pueraria lobata, 15 parts of Asarum heterotropoides, 15 parts of Pheretima aspergillum, 15 parts of Lonicera japonica, and 10 parts of Glycyrrhiza uralensis.

[0010] In a second aspect, the present invention provides a method for preparing the traditional Chinese medicine composition described in the first aspect above. The preparation method includes the following steps: pulverizing Codonopsis pilosula, Phellodendron chinense, Ligusticum chuanxiong, Acanthopanax senticosus, Pueraria lobata, Asarum sieboldii, Pheretima aspergillum, Lonicera japonica, and Glycyrrhiza uralensis, adding water to decoct, mixing the filtrate, and concentrating to obtain a concentrated solution.

[0011] As an optional method, in the above preparation method, the decoction is performed twice. After the first decoction is performed for 1-3 hours, the liquid is filtered to obtain a first filtrate. The residue is then added to water and decocted for another 1-3 hours, and filtered to obtain a second filtrate. The first and second filtrates are then combined.

[0012] Alternatively, in the above preparation method, the ratio of material to liquid in the first decoction and the second decoction is 1:3, the decoction time for the first decoction and the second decoction is 1 hour, and the water used for the first decoction and the second decoction is distilled water.

[0013] Preferably, the concentration is a vacuum concentration.

[0014] In a third aspect, the present invention provides the use of the traditional Chinese medicine composition described in the first aspect above, or the traditional Chinese medicine composition prepared by the preparation method described in the second aspect above, in the preparation of a medicament for treating peripheral neuritis.

[0015] Alternatively, the peripheral neuritis described in the above uses may be peripheral neuritis or polyneuritis.

[0016] Preferably, the peripheral neuritis is selected from one or more of the following: facial nerve palsy, diabetic peripheral neuritis, viral peripheral neuritis, chemotherapy-induced peripheral neuritis, or Guillain-Barré syndrome.

[0017] Alternatively, in the above-described uses, the symptoms of peripheral neuritis include decreased sensation, pain, numbness or tingling, tingling, burning, and hyperesthesia.

[0018] As an alternative, in the above-mentioned uses, the drug has the effects of promoting blood circulation, removing blood stasis, clearing the meridians, replenishing qi and nourishing blood, and is mainly used to treat patients with peripheral neuritis of the qi stagnation and blood stasis type.

[0019] Alternatively, in the above-mentioned uses, the drug is in solid, semi-solid, or liquid form, and the drug is in the form of decoction pieces, broth, powder, oral liquid, ointment, granules, tablets, or capsules.

[0020] In fact, the drug of the present invention can be prepared using conventional methods in the art, with or without pharmaceutically acceptable excipients. As long as the raw materials of traditional Chinese medicine are in the above-mentioned weight proportions, any variations in the preparation method fall within the scope of the present invention.

[0021] Compared with the prior art, the present invention has the following advantages:

[0022] (1) The traditional Chinese medicine composition of the present invention has the effects of promoting blood circulation, removing blood stasis, clearing collaterals, replenishing qi and nourishing blood, clearing heat and detoxifying, and is mainly used to treat patients with peripheral neuritis of qi stagnation and blood stasis type.

[0023] (2) Experimental results show that the herbal composition of the present invention can effectively improve symptoms such as numbness, pain, and paresthesia in patients with peripheral nerve diseases, with significant therapeutic effects and no toxic side effects. In addition, the herbal composition of the present invention can also repair damaged nerves in patients and improve the conduction velocity of sensory nerves and motor nerves in patients. Detailed Implementation

[0024] The present invention will be further described below with reference to specific embodiments. It should be understood that the specific embodiments described herein are for illustrative purposes only and are not intended to limit the scope of the invention.

[0025] The application and research progress of the main components in the traditional Chinese medicine composition of this invention are as follows:

[0026] "Codonopsis pilosula" is the dried root of *Codonopsis pilosula*, *Codonopsis lanceolata*, or *Codonopsis chuanxiong*, all belonging to the Campanulaceae family. Codonopsis pilosula is sweet and neutral in nature. It enters the spleen and lung meridians. While sweet and nourishing, it is neither drying nor greasy, and its qi-tonifying effect is weaker than that of ginseng, so it is mostly used for mild cases of spleen and lung qi deficiency. It also promotes the production of body fluids and nourishes blood, and can treat conditions such as fluid depletion and blood deficiency.

[0027] "Huangbai" is the dried bark of the Huangpi tree, a plant in the Rutaceae family. Huangbai is bitter, cold, and drying, and enters the kidney and bladder meridians. It clears and drains excess heat and detoxifies, dries dampness, eliminates damp-heat toxins, and clears kidney fire to reduce deficiency heat. It is a key medicine for treating damp-heat and fire toxins and is widely used for related symptoms. Compared to Huanglian (Coptis chinensis), it has a weaker heat-clearing and dampness-drying effect, and its action is more focused on the kidneys and lower bladder. It is best at clearing ministerial fire, reducing deficiency heat, and eliminating damp-heat in the lower jiao. It combines the functions of clearing excess heat, damp-heat, and reducing deficiency heat, making it suitable for all types of excess heat, damp-heat, and deficiency heat.

[0028] "Chuanxiong" is the dried rhizome of the umbelliferous plant *Ligusticum chuanxiong*. Chuanxiong is warm in nature and enters the liver, gallbladder, and pericardium meridians. It is pungent, aromatic, dispersing, and warming, entering these meridians. It ascends to the head and descends to the blood center, internally promoting blood circulation and externally dispelling wind and cold. It has a strong blood-activating effect and treats various pains caused by blood stasis and qi stagnation, especially those accompanied by cold. It was praised by the ancients as "the qi-regulating medicine within the blood." It is best for treating various headaches caused by wind-cold and blood stasis; it can also be used for those caused by wind-heat, wind-dampness, and blood deficiency.

[0029] "Eleutherococcus senticosus" refers to the dried root, rhizome, or stem of the plant Eleutherococcus senticosus, belonging to the Araliaceae family. Eleutherococcus senticosus is pungent, slightly bitter, and warm in nature. It enters the spleen, kidney, and heart meridians. Eleutherococcus senticosus is sweet and tonifying, pungent and warming, and slightly bitter and purging. Entering the spleen meridian, it effectively tonifies qi and strengthens the spleen, treating spleen deficiency and fatigue, and qi deficiency and edema; entering the kidney meridian, it effectively benefits the kidneys and strengthens the lower back, treating kidney deficiency, lower back and knee weakness, and delayed walking in children; entering the heart meridian, it effectively nourishes the heart and calms the mind, treating palpitations and insomnia; it travels through the meridians, effectively promoting blood circulation and unblocking the meridians, treating chest pain, arthralgia, and injuries from falls and blows.

[0030] "Kudzu root" is the dried root of the kudzu plant (Pueraria lobata), a legume. Kudzu root is sweet, pungent, and cool in nature. It enters the spleen, stomach, and lung meridians. Kudzu root is sweet, pungent, light, and dispersing, neutral with a slight cooling effect, and enters the spleen and stomach meridians. It can both release wind-heat from the skin surface, reduce fever, and promote the eruption of rashes, and also invigorate the spleen and stomach's clear yang to rise, generating fluids and quenching thirst, and raising yang to stop diarrhea. It is most suitable for treating stiff neck and back pain and yangming headache, regardless of whether it is due to cold or heat, deficiency or excess, or with or without sweating. When used raw, it disperses and clears, and generates fluids; when simmered, it is better at raising but less clearing.

[0031] Asarum is the dried root and rhizome of *Asarum heterotropoides*, *Asarum sieboldii*, or *Asarum huaxinense*, all belonging to the Aristolochiaceae family. Asarum is pungent and warm in nature. It enters the heart, lung, and kidney meridians. With its strong aromatic scent and pungent, warm properties, it penetrates the heart, lung, and kidney meridians, reaching both the interior and exterior, and possesses a strong disinfecting effect. It excels at dispelling wind and cold, clearing the nasal passages, and relieving pain, making it an excellent medicine for treating various pains caused by wind-cold and wind-dampness, as well as nasal congestion and headaches due to sinusitis. It can warm and disperse lung cold and resolve phlegm, making it a key medicine for treating cold phlegm lurking in the lungs. It is most suitable for treating headaches due to Shaoyin syndrome, nasal congestion, and toothache.

[0032] "Earthworm" refers to the dried body of several species of the family Lumbriaceae, including *Pheretima asiatica*, *Pheretima vulgaris*, *Pheretima wieldii*, and *Pheretima protozoa*. Earthworm is salty and cold in nature, and enters the liver, spleen, and bladder meridians. Its salty and cold properties clear and drain, promoting circulation and facilitating flow. Entering the liver meridian, it clears heat, calms wind, and stops spasms; entering the lung meridian, it clears lung heat and relieves asthma; entering the bladder meridian, it promotes urination and relieves constipation; and by traversing the meridians, it unblocks the channels and treats numbness. Earthworm possesses the effects of clearing heat and calming convulsions, unblocking the channels, relieving asthma, and promoting urination. It is commonly used for high fever with delirium, convulsions, joint paralysis, limb numbness, hemiplegia, lung heat with cough and asthma, and edema with oliguria.

[0033] Honeysuckle is the dried flower bud or newly opened flower of *Lonicera japonica*, a plant in the Caprifoliaceae family. Honeysuckle is sweet and cold in nature, and enters the lung, stomach, and large intestine meridians. It is sweet and cold in nature, clearing and dispersing heat, and enters these meridians. It is effective in clearing heat toxins and dispersing wind-heat. It is quite potent without being bitter or purging, making it an excellent medicine for clearing heat toxins, and it is easy to take without being bitter. It primarily clears heat while also dispersing wind-heat, and can be used for all types of heat toxins and wind-heat. It is suitable for all stages of febrile diseases and is often combined with forsythia. In the Wei level, it can penetrate the exterior; in the Qi level, it can clear heat; in the Ying level, it can promote the transformation of Ying and Qi; and in the blood level, it can clear heat toxins in the blood.

[0034] Licorice is a perennial herb belonging to the genus *Glycyrrhiza* in the legume family. It is recorded in numerous Chinese herbal medicine books throughout history. Not only is it a valuable medicine, but it is also known as the "King of Herbs." The "Dingchuan Decoction" (containing ephedra, ginkgo, mulberry bark, perilla seed, apricot kernel, scutellaria, coltsfoot flower, pinellia, and licorice) from the Ming Dynasty's *She Sheng Zhong Miao Fang* is effective in treating chronic bronchitis and wheezing bronchitis. Furthermore, licorice can detoxify various medicines, hence its Chinese association with "detoxification." It also symbolizes "harmony" and "regulation" due to its ability to harmonize other herbs.

[0035] Where specific techniques or conditions are not specified in the examples, they shall be performed in accordance with the techniques or conditions described in the literature in this field, or in accordance with the product instructions. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased through legitimate channels.

[0036] Unless otherwise specified, the experimental methods used in the following embodiments are conventional methods. Unless otherwise specified, the experimental materials used in the following embodiments are commercially available products.

[0037] Preparation Example:

[0038] Example 1:

[0039] A traditional Chinese medicine composition for treating peripheral neuritis, the composition being made from the following raw materials in parts by weight: Codonopsis pilosula 20g, Phellodendron chinense 20g, Ligusticum chuanxiong 20g, Acanthopanax senticosus 20g, Pueraria lobata 15g, Asarum heterotropoides 15g, Pheretima aspergillum 15g, Lonicera japonica 15g, and Glycyrrhiza uralensis 10g.

[0040] All raw materials are pulverized into fine powder, and 1000 mL of distilled water is added for decoction. After the first decoction is completed and 1.5 hours have passed, the liquid is filtered to obtain a first filtrate. The residue is then decocted again with 1000 mL of distilled water for 1.5 hours and filtered to obtain a second filtrate. The first and second filtrates are combined and concentrated under reduced pressure to obtain 300 mL of concentrated liquid. The concentrate is filtered and concentrated to 50°C to obtain a clear extract with a relative density of 1.25-1.30. The extract is dried below 80°C, pulverized, granulated, compressed into tablets, and coated with sugar or film to obtain the final product.

[0041] Comparative Example 1:

[0042] A traditional Chinese medicine composition, wherein the traditional Chinese medicine composition is made from the following raw materials in parts by weight: ginseng 20g, phellodendron bark 20g, chuanxiong rhizome 20g, eleutherococcus senticosus 20g, kudzu root 15g, asarum root 15g, earthworm 15g, honeysuckle 15g, and licorice root 10g.

[0043] All raw materials are pulverized into fine powder, and 1000 mL of distilled water is added for decoction. After the first decoction is completed and 1.5 hours have passed, the liquid is filtered to obtain a first filtrate. The residue is then decocted again with 1000 mL of distilled water for 1.5 hours and filtered to obtain a second filtrate. The first and second filtrates are combined and concentrated under reduced pressure to obtain 300 mL of concentrated liquid. The concentrate is filtered and concentrated to 50°C to obtain a clear extract with a relative density of 1.25-1.30. The extract is dried below 80°C, pulverized, granulated, compressed into tablets, and coated with sugar or film to obtain the final product.

[0044] Comparative Example 2:

[0045] A traditional Chinese medicine composition, wherein the traditional Chinese medicine composition is made from the following raw materials in parts by weight: Codonopsis pilosula 20g, Phellodendron chinense 35g, Ligusticum chuanxiong 20g, Acanthopanax senticosus 20g, Pueraria lobata 15g, Asarum heterotropoides 15g, Pheretima aspergillum 15g, and Glycyrrhiza uralensis 10g.

[0046] All raw materials are pulverized into fine powder, and 1000 mL of distilled water is added for decoction. After the first decoction is completed and 1.5 hours have passed, the liquid is filtered to obtain a first filtrate. The residue is then decocted again with 1000 mL of distilled water for 1.5 hours and filtered to obtain a second filtrate. The first and second filtrates are combined and concentrated under reduced pressure to obtain 300 mL of concentrated liquid. The concentrate is filtered and concentrated to 50°C to obtain a clear extract with a relative density of 1.25-1.30. The extract is dried below 80°C, pulverized, granulated, compressed into tablets, and coated with sugar or film to obtain the final product.

[0047] Example of effect:

[0048] 1. General patient information:

[0049] All 100 patients met the diagnostic criteria for peripheral neuritis (qi stagnation and blood stasis type) and were divided into 4 groups of 25 patients each. There were no significant differences among the groups in terms of gender, age, and disease duration.

[0050] Diagnostic criteria for peripheral neuritis (all cases were diagnosed based on the content of "Neurology" edited by Wang Weizhi):

[0051] (1) Clinical manifestations: irritability, or worsening at night, or numbness of limbs, or symmetrical weakness of distal limbs, or low muscle tone, or weakened or absent tendon reflexes, or muscle atrophy, etc., which are aggravated by abnormal emotions, pain like needle pricks, dark red and purplish tongue, yellow and greasy coating, and wiry or hesitant pulse.

[0052] (2) Abnormal electromyography and nerve conduction velocity measurements.

[0053] 2. Treatment methods and course of treatment:

[0054] Group 1: The tablets prepared in Example 1 are taken orally, 2 tablets each time, 3 times a day, for 15 days as one course of treatment.

[0055] Group 2: The tablets prepared in Comparative Example 1 were taken orally, 2 tablets each time, 3 times a day, for 15 days as one course of treatment.

[0056] Group 3: The tablets prepared in Comparative Example 2 were taken orally, 2 tablets each time, 3 times a day, for 15 days as one course of treatment.

[0057] Group 4: Vitamin B1 and methylcobalamin are used in combination. Vitamin B1 tablets are taken orally, 10 mg each time, 3 times a day. Methylcobalamin tablets are taken orally, 0.5 mg each time, 3 times a day. One course of treatment is 15 days.

[0058] 3. Criteria for evaluating therapeutic efficacy:

[0059] (1) Clinical cure: Symptoms such as sensory disturbances and muscle weakness disappear, muscle strength and sensation return to normal, and electromyography and nerve conduction velocity (NCV) return to normal.

[0060] (2) Significant effect: Various symptoms basically disappeared, and electromyography and NCV measurement showed significant improvement.

[0061] (3) Effective: Various symptoms were significantly improved, and electromyography and NCV measurements showed some improvement.

[0062] (4) Ineffective: No change in various symptoms or symptoms may be relieved but not lasting, and then return to the previous state. Electromyography and NCV measurements show no improvement.

[0063] 4. Statistical analysis methods:

[0064] Results were analyzed using SPSS 23.0 statistical software, and data are expressed as mean ± standard deviation. One-way ANOVA was used for comparisons among multiple groups, and t-tests were used for comparisons between two groups. A p-value < 0.05 was considered statistically significant.

[0065] 5. Clinical efficacy observation results:

[0066] 5.1 Clinical observation results of the herbal composition of the present invention in the treatment of peripheral neuritis:

[0067] As shown in Table 1, the experimental results indicate that the treatment effect of peripheral neuritis in Group 1 was comparable to that in Group 4, and significantly better than that in Groups 2 and 3. Furthermore, the experimental results from Groups 2 and 3 also show that when some of the medicinal ingredients in the herbal composition of this invention are replaced with those having similar effects (e.g., replacing Codonopsis pilosula with ginseng), or when some of the medicinal ingredients with similar effects are removed from the herbal composition of this invention (e.g., removing honeysuckle), the therapeutic effect of the herbal composition on peripheral neuritis is significantly reduced.

[0068] Table 1: Clinical observation results of the traditional Chinese medicine composition of the present invention in the treatment of peripheral neuritis

[0069]

[0070] 5.2 Comparison of sensory nerve conduction velocities in patients before and after treatment with the herbal composition of the present invention:

[0071] As shown in Table 2, the experimental results showed that, compared with before treatment, the sensory nerve conduction velocities of the median and peroneal nerves in patients in groups 1 and 4 increased significantly after treatment, while the conduction velocities of the two nerves in groups 2 and 3 did not change significantly before and after treatment.

[0072] Table 2: Comparison of sensory nerve conduction velocities before and after treatment (mean ± standard deviation, m / s)

[0073]

[0074] The above results indicate that the herbal composition of the present invention can effectively improve symptoms such as numbness, pain, and paresthesia in patients with peripheral nerve diseases. Its effect is similar to that of the most commonly used combination of vitamin B1 and methylcobalamin in clinical practice, and it has no obvious toxic side effects.

[0075] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A traditional Chinese medicine composition for treating peripheral neuritis, characterized in that: The traditional Chinese medicine composition is made of raw medicinal materials in the following weight parts: Radix Codonopsis 5-40 parts, Phellodendri Cortex 5-40 parts, Chuanxiong Rhizoma 5-40 parts, Acanthopanax 5-30 parts, Pueraria 5-30 parts, Asarum 5-30 parts, Earthworm 5-30 parts, Lonicera japonica 5-30 parts, and Glycyrrhiza 5-20 parts. ​ 2. The traditional Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition is made of raw medicinal materials in the following weight parts: Radix Codonopsis 10-30 parts, Phellodendri Cortex 10-30 parts, Chuanxiong Rhizoma 10-30 parts, Acanthopanax 10-20 parts, Pueraria 10-20 parts, Asarum 10-20 parts, Earthworm 10-20 parts, Lonicera japonica 10-20 parts, and Glycyrrhiza 5-15 parts.

3. The traditional Chinese medicine composition according to claim 2, characterized in that: The traditional Chinese medicine composition is made of raw medicinal materials in the following weight parts: Radix Codonopsis 20 parts, Phellodendri Cortex 20 parts, Chuanxiong Rhizoma 20 parts, Acanthopanax 20 parts, Pueraria 15 parts, Asarum 15 parts, Earthworm 15 parts, Lonicera japonica 15 parts, and Glycyrrhiza 10 parts.

4. The preparation method of the traditional Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The preparation method comprises the following steps: crushing Radix Codonopsis, Phellodendri Cortex, Chuanxiong Rhizoma, Acanthopanax, Pueraria, Asarum, Earthworm, Lonicera japonica, and Glycyrrhiza, adding water to decoct, mixing the filtrate, and preparing a concentrated liquid through concentration.

5. The production method according to claim 4, characterized by, The decoction is performed twice, and the filtrate is obtained after the first decoction for 1-3 hours, and the filtrate is obtained after the second decoction for 1-3 hours after adding water to the residue of the first decoction.

6. The method of claim 5, wherein: The material-liquid ratio of the first decoction and the second decoction is 1:3, the decoction time of the first decoction and the second decoction is 1 hour, and the water used in the first decoction and the second decoction is distilled water.

7. The method of claim 6, wherein: The concentration is reduced-pressure concentration.

8. Use of the traditional Chinese medicine composition of any one of claims 1 to 3 or the traditional Chinese medicine composition prepared by the preparation method of any one of claims 4 to 7 in the preparation of a medicine for treating peripheral neuritis.

9. Use according to claim 8, characterized in that: The peripheral neuritis is peripheral neuritis or multiple neuritis. The traditional Chinese medicine composition is made of raw medicinal materials in the following weight parts: Radix Codonopsis 5-40 parts, Phellodendri Cortex 5-40 parts, Chuanxiong Rhizoma 5-40 parts, Acanthopanax 5-30 parts, Pueraria 5-30 parts, Asarum 5-30 parts, Earthworm 5-30 parts, Lonicera japonica 5-30 parts, and Glycyrrhiza 5-20 parts. The traditional Chinese medicine composition is made of raw medicinal materials in the following weight parts: Radix Codonopsis 10-30 parts, Phellodendri Cortex 10-30 parts, Chuanxiong Rhizoma 10-30 parts, Acanthopanax 10-20 parts, Pueraria 10-20 parts, Asarum 10-20 parts, Earthworm 10-20 parts, Lonicera japonica 10-20 parts, and Glycyrrhiza 5-15 parts. The traditional Chinese medicine composition is made of raw medicinal materials in the following weight parts: Radix Codonopsis 20 parts, Phellodendri Cortex 20 parts, Chuanxiong Rhizoma 20 parts, Acanthopanax 20 parts, Pueraria 15 parts, Asarum 15 parts, Earthworm 15 parts, Lonicera japonica 15 parts, and Glycyrrhiza 10 parts. The preparation method comprises the following steps: crushing Radix Codonopsis, Phellodendri Cortex, Chuanxiong Rhizoma, Acanthopanax, Pueraria, Asarum, Earthworm, Lonicera japonica, and Glycyrrhiza, adding water to decoct, mixing the filtrate, and preparing a concentrated liquid through concentration. The decoction is performed twice, and the filtrate is obtained after the first decoction for 1-3 hours, and the filtrate is obtained after the second decoction for 1-3 hours after adding water to the residue of the first decoction. The material-liquid ratio of the first decoction and the second decoction is 1:3, the decoction time of the first decoction and the second decoction is 1 hour, and the water used in the first decoction and the second decoction is distilled water. The concentration is reduced-pressure concentration.

8. Use of the traditional Chinese medicine composition of any one of claims 1 to 3 or the traditional Chinese medicine composition prepared by the preparation method of any one of claims 4 to 7 in the preparation of a medicine for treating peripheral neuritis. The peripheral neuritis is peripheral neuritis or multiple neuritis.

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