Oral liquid for preventing and treating perinatal energy metabolism disorder disease of dairy cows and preparation method thereof

Abstract

The present application relates to the technical field of oral liquid, in particular to a kind of oral liquid for preventing and treating perinatal energy metabolism disorder disease of dairy cow and preparation method thereof, it is characterized in that, the oral liquid for preventing and treating perinatal energy metabolism disorder disease of dairy cow is made of the following components, by weight parts: artemisia capillaris 200~300 parts, gardenia 150~200 parts, bupleurum 100~150 parts, polygonatum 50~100 parts, radix paeoniae alba 50~100 parts, liquorice 10~50 parts, nicotinic acid 1~10 parts, propylene glycol 200~300 parts, fructose diphosphate sodium 1~10 parts, pure water 200~400 parts.The oral liquid for preventing and treating perinatal energy metabolism disorder disease of dairy cow can prevent and treat ketosis, fatty liver and liver damage at the same time, comprehensively improve the constitution of new cow, improve immunity, improve physical indicators and reproductive performance, increase economic benefits.

Description

Technical Field

[0001] This invention relates to the field of oral liquid technology, specifically to an oral liquid for preventing and treating peripartum energy metabolism disorders in dairy cows and its preparation method. Background Technology

[0002] The peripartum period is a critical and special period in dairy cow production. The most prominent feature of this period is the negative energy balance, which is also the peak period for energy metabolism disorders in dairy cows.

[0003] Perinatal metabolic diseases in dairy cows include ketosis and fatty liver.

[0004] Ketosis is a metabolic disorder in dairy cows characterized by hypoglycemia, resulting from a disorder of carbohydrate and fat metabolism that leads to the accumulation of large amounts of ketone bodies in the blood, which are then excreted through urine, milk, and exhaled gases. Ketosis is the most common and harmful metabolic disease in peripartum dairy cows, reducing milk yield and quality, and increasing the risk of mastitis, endometritis, and abomasal displacement, causing significant economic losses to the dairy farming industry.

[0005] Fatty liver disease, also known as obesity in cows, is a peripartum metabolic disease caused by the mobilization of body fat due to a negative energy balance in dairy cows. It is characterized by fat accumulation and fatty degeneration in the liver. It mainly occurs in high-producing dairy cows from 2 to 3 weeks before calving to 4 to 5 weeks after calving. It has a high incidence rate and can greatly harm the health and production performance of dairy cows.

[0006] Studies by Drackley et al. have shown that almost all cattle with ketosis have varying degrees of hepatic fat accumulation, which can cause or aggravate ketosis, and the two are closely related. Fat mobilization is an inevitable result of negative energy balance in dairy cows during the peripartum period. Negative energy balance is the cause, fat mobilization is the effect, and increased ketone body production (ketosis) and increased hepatic fat accumulation (fatty liver) are the consequences. High fatty acids and hyperketosis have lipotoxicity and can cause oxidative stress in hepatocytes. Large amounts of reactive oxygen species can cause hepatocyte apoptosis and inflammatory responses, producing large amounts of interleukin-6 and tumor necrosis factor, etc. Hepatocyte apoptosis and inflammatory responses further cause and aggravate liver damage, making ketosis recurrent and difficult to cure. Therefore, in addition to glucose supplementation and antiketosis, the treatment of ketosis in dairy cows should also alleviate oxidative stress, inflammation, and other pathological damage.

[0007] Therefore, it is necessary to provide a drug for the prevention and treatment of energy metabolism disorders in dairy cows during the peripartum period.

[0008] Patent CN 114343066 B discloses a feed additive for preventing ketosis in dairy cows and improving their production and reproductive performance. It uses a compound microorganism composed of brewer's yeast, Aspergillus oryzae, Aspergillus niger, Trichoderma viride and lactic acid bacteria, mixed with corn flour as a base material. Astragalus membranaceus, Codonopsis pilosula, stir-fried Atractylodes macrocephala, Poria cocos, roasted Glycyrrhiza uralensis, Angelica sinensis, Artemisia capillaris, Gardenia jasminoides, charred hawthorn, charred malt, charred Shenqu, Citrus aurantium, Sparganium stoloniferum, Curcuma zedoaria, Curcuma longa, Sanguisorba officinalis and Rheum palmatum are anaerobic fermented for 7 days. This feed additive can not only effectively prevent and treat ketosis in newborn cows, but also increase milk yield and milk quality, improving various physiological indicators of newborn dairy cows in multiple ways. However, the preparation method and ingredients are very complicated, and it does not have a synergistic therapeutic effect on fatty liver in dairy cows. Patent CN 110721173 B discloses a preparation for the prevention and treatment of ketosis in dairy cows and its preparation method. The preparation for treating ketosis in dairy cows is based on a common propylene glycol preparation with the addition of medium-chain fatty acids and choline chloride. In addition to treating ketosis, it also focuses on solving the problem of postpartum ketosis caused by liver metabolic disorders due to excessive fat accumulation in obese cows in the pre-partum period. At the same time, it can provide high-quality energy to ensure the energy needs during the peripartum period. However, this preparation fails to achieve both symptomatic and root-cause treatment, as well as the prevention and treatment of liver damage.

[0009] Therefore, developing a drug that is effective, low-cost, and suitable for large-scale application in the prevention and treatment of periparturient dairy cow energy metabolism disorders is of great significance in livestock production practices. Summary of the Invention

[0010] The purpose of this invention is to provide an oral liquid for preventing and treating energy metabolism disorders in periparturient dairy cows and its preparation method.

[0011] This invention is achieved using the following technical solution:

[0012] An oral liquid for preventing and treating energy metabolism disorders in periparturient dairy cows is made from the following components in parts by weight: 200-300 parts Artemisia capillaris, 150-200 parts Gardenia jasminoides, 100-150 parts Bupleurum chinense, 50-100 parts Polygonatum sibiricum, 50-100 parts Paeonia lactiflora, 10-50 parts Glycyrrhiza uralensis, 1-10 parts Nicotinic acid, 200-300 parts Propylene glycol, 1-10 parts Sodium fructose diphosphate, and 200-400 parts purified water.

[0013] The preparation method of the above oral liquid is as follows: Take Artemisia capillaris, Gardenia jasminoides, Bupleurum chinense, Polygonatum sibiricum, Paeonia lactiflora, and Glycyrrhiza uralensis, add 10-20 times the amount of water and soak for 1-3 hours, decoct twice, each time for 2-4 hours, combine the filtrates, centrifuge, and concentrate the filtrate to a relative density of 1.02-1.05 g / mL. Add nicotinic acid, propylene glycol, fructose diphosphate sodium, and purified water, stir well, filter, dispense, and sterilize to obtain the oral liquid.

[0014] In the drug described in this invention:

[0015] Artemisia capillaris Thunb.:

[0016] Meridians entered: Spleen, Stomach, Liver, Gallbladder meridians.

[0017] Nature and flavor: Bitter, pungent, slightly cold.

[0018] Functions and indications: Clearing damp-heat and reducing jaundice. Used for oliguria with jaundice, itchy eczema; infectious jaundice hepatitis.

[0019] Pharmacological research: It has effects such as promoting bile secretion, antipyretic, hepatoprotective, lipid-lowering, blood pressure-lowering, antiasthmatic, antibacterial, antiviral, diuretic, anticancer, analgesic, anti-caries, anti-inflammatory, etc., and has an inhibitory effect on hepatitis virus.

[0020] 1. "Explanation of the Classic of Materia Medica": Artemisia capillaris Thunb. is mainly used for rheumatic cold and heat, pathogenic heat binding, jaundice, general body jaundice, dysuria and headache. All these are diseases caused by damp-heat in the Yangming and Taoyin meridians. Bitter and cold can dry dampness and remove heat. When damp-heat is removed, all these symptoms will subside. It is an important herb for removing dampness and dissipating heat knots.

[0021] 2. "Commentary on the Classics of Materia Medica": It promotes the development of the old and brings forth the new, which is different from other herbs that expel damp-heat, and it is especially difficult to match those that have the effect of promoting diuresis.

[0022] 3. "Illustrated Explanation of Materia Medica": There are two types of jaundice, yin jaundice and yang jaundice. Artemisia capillaris Thunb. is combined with Gardenia jasminoides Ellis and Polygonatum sibiricum Redoute to treat yang jaundice, and combined with Aconitum carmichaeli Debx. and Zingiber officinale Rosc. to treat yin jaundice. Generally speaking, Artemisia capillaris Thunb. is used as the main herb, and it regulates the yin and yang of jaundice syndrome according to the cold and heat of the adjuvant and envoy herbs.

[0023] 4. "Supplementary Records of the Classic of Materia Medica": Artemisia capillaris Thunb. grows on Mount Tai and on the slopes and banks of hills. It is collected in May and at the beginning of autumn and dried in the shade. It is used to treat general body jaundice, dysuria, remove headache, and eliminate latent masses.

[0024] Gardenia jasminoides Ellis:

[0025] Meridians entered: Heart, Lung, Sanjiao meridians.

[0026] Nature and flavor: Bitter, cold.

[0027] Functions and indications: Removing fire and relieving restlessness, clearing heat and promoting diuresis, cooling blood and detoxifying. Used for restlessness due to febrile disease, jaundice with red urine, stranguria with blood pain, hematemesis and epistaxis due to blood heat, red and swollen eyes, fire-toxin ulcers; externally used for sprains and contusions.

[0028] Pharmacological research: Protecting the digestive system; purgative; reducing temperature; increasing the synthesis of DNA and protein in cells; antibacterial; anti-inflammatory; enhancing the secretion of bile and thus having the effects of promoting bile secretion and inhibiting the formation of bilirubin in the blood; inhibiting the central nervous system and thus having the effects of sedation, blood pressure-lowering, anti-convulsion, and analgesia; having an inhibitory effect on a variety of pathogenic bacteria in vitro experiments.

[0029] 1. It is an essential medicine for treating fever with restlessness and agitation. It can be used with fermented soybeans, such as in Gardenia and Fermented Soybean Decoction (Treatise on Cold Damage). For treating fever with intense fire toxicity, with heat in all three jiaos and symptoms of high fever, restlessness, delirium, and coma, it can be combined with Scutellaria baicalensis, Coptis chinensis, Polygonatum sibiricum, etc., such as in Coptis chinensis Decoction (Secret Essentials from the Outer Terrace).

[0030] 2. For jaundice caused by damp-heat stagnation in the liver and gallbladder, it is often combined with Artemisia capillaris and rhubarb, such as in Artemisia capillaris Decoction (Shang Han Lun), or with Polygonatum sibiricum, such as in Gardenia and Phellodendron bark Decoction (Jin Ni Yao Lue).

[0031] 3. For treating painful and difficult urination with blood or heat-induced urination, it is often combined with Akebia, Plantago seed, Talcum, etc., such as Bazheng Powder (from the Imperial Pharmacy).

[0032] 4. For treating hematemesis and epistaxis caused by blood heat, it is often combined with Imperata cylindrica root, rhubarb, and Platycladus orientalis leaves, such as in Shi Hui San (Shi Yao Shen Shu); for treating hematemesis and epistaxis caused by excessive fire in the Triple Burner forcing blood to flow erratically, it is combined with Scutellaria baicalensis, Coptis chinensis, and Polygonatum sibiricum, such as in Huang Lian Jie Du Tang (Wai Tai Mi Yao).

[0033] 5. For treating red, swollen, and painful eyes caused by liver and gallbladder fire attacking upwards, rhubarb is often added, such as in Gardenia Decoction (from "Shengji Zonglu").

[0034] 6. For treating boils and carbuncles with redness, swelling, heat and pain caused by fire toxins, it is often combined with white peony root, forsythia, and dandelion; or combined with angelica root to help reduce swelling, such as in the Suodu San (from "Puji Fang").

[0035] Bupleurum:

[0036] Meridian Tropism: Liver Meridian, Gallbladder Meridian, Lung Meridian.

[0037] Properties: Slightly cold in nature, bitter in taste.

[0038] Indications: Harmonizes the exterior and interior, soothes the liver, and promotes Yang. Used for colds with fever, alternating chills and fever, chest and rib pain, irregular menstruation, uterine prolapse, and rectal prolapse.

[0039] Pharmacological studies: Pharmacological tests have shown that Bupleurum has anti-inflammatory, antipyretic, sedative, analgesic, antitussive and anticonvulsant effects; it can reduce liver damage and promote bile secretion; it has antihypertensive, serum cholesterol-lowering and hemolytic effects; it also has anti-ulcer, antibacterial, antiviral, antitumor, blood sugar-raising, blood lipid-lowering and anti-radiation damage effects.

[0040] 1. For treating exogenous wind-cold, fever and chills, headache and body aches: Bupleurum chinense 3-9g, Saposhnikovia divaricata 3g, Citrus reticulata peel 4.5g, Paeonia lactiflora 6g, Glycyrrhiza uralensis 3g, and 3-5 slices of fresh ginger. Boil in 1.5 cups of water until reduced to 70-80%. Drink hot. (From *Jingyue Quanshu*, Zheng Chaihu Yin)

[0041] 2. For treating malaria, characterized by predominantly chills and less fever, and abdominal distension: Take 6 grams each of Bupleurum chinense, Pinellia ternata, Magnolia officinalis, and Citrus reticulata peel. Decoct in two bowls of water until reduced to eight-tenths of the original volume. Take at any time. (From *Compendium of Materia Medica*)

[0042] 3. For treating hypochondriac pain with alternating chills and fever: Bupleurum chinense 6g, Ligusticum chuanxiong, Citrus aurantium (stir-fried with wheat bran), Paeonia lactiflora 4.5g, Glycyrrhiza uralensis (prepared) 1.5g, Cyperus rotundus 4.5g. Decoct in one and a half cups of water until reduced to eight-tenths of the original volume. Take before meals. (Bupleurum Liver-Soothing Powder from *Jingyue Quanshu*)

[0043] 4. For jaundice: Bupleurum (without the stem) 30g, licorice 0.3g. Finely chop both ingredients into one dose, add one bowl of water and a handful of Imperata cylindrica root, decoct together until reduced to seven-tenths, strain out the dregs. Take as desired throughout the day. (From *Sun Shang Yao Fang*)

[0044] 5. For persistent diarrhea due to accumulated heat: 12 grams each of Bupleurum chinense and Scutellaria baicalensis. Decocted in water and taken orally. (From *Sheng Hui Fang*)

[0045] Polygonatum:

[0046] Meridian Tropism: Kidney and Bladder Meridians.

[0047] Properties: Bitter, cold. It enters the kidney and bladder meridians.

[0048] Functions and indications: Tonifies Qi and nourishes Yin, strengthens the spleen, moistens the lungs, and benefits the kidneys.

[0049] Pharmacological studies show that Polygonatum sibiricum can increase coronary blood flow, regulate blood lipids, lower blood sugar, resist aging, and enhance immunity. Crude polysaccharides from Polygonatum sibiricum have immunomodulatory effects, protect against chemically induced liver damage, and also possess anti-inflammatory and antiviral properties. Furthermore, it has antibacterial, antimicrobial, hypotensive, and hemostatic effects; modern clinical applications include the treatment of coronary heart disease, hyperlipidemia, diabetes, leukopenia, tuberculosis, chronic hepatitis, mental fatigue and sleep deprivation, headaches, impotence, and tinea.

[0050] 1. To strengthen muscles and bones, nourish essence and marrow, and turn gray hair back on: 4 catties each of Polygonatum sibiricum and Atractylodes lancea, 5 catties each of Lycium barbarum root and Platycladus orientalis leaves, and 3 catties of Asparagus cochinchinensis. Boil to extract one shi of juice, add 10 catties of yeast and one shi of glutinous rice, and brew wine as usual. (Compendium of Materia Medica)

[0051] 2. To replenish essence and qi: Equal parts of wolfberry (preferably harvested in winter) and polygonatum. Grind into a fine powder, combine the two ingredients, pound into a clump, shape into cakes, dry, pound again into a powder, and mix with refined honey to form pills the size of a paulownia seed. Take fifty pills each time with warm water on an empty stomach. (From *Qixiao Liangfang*, Wolfberry Pills)

[0052] 3. For treating spleen and stomach weakness, fatigue and weakness: one ounce each of Polygonatum sibiricum, Codonopsis pilosula, and Dioscorea opposita, steamed with chicken and eaten. (From "Handbook of Commonly Used Chinese Herbal Medicines in Rural Hunan")

[0053] 4. For treating pulmonary tuberculosis with hemoptysis and leukorrhea: 2 ounces of fresh Polygonatum root and 1 ounce of rock sugar. Stew in boiling water and drink. (From "Min Dong Materia Medica")

[0054] 5. For treating pulmonary tuberculosis and post-illness weakness: 5-10 grams of Polygonatum sibiricum. Decoct in water and drink or stew with pork. (From *Handbook of Commonly Used Traditional Chinese Medicines in Rural Hunan*)

[0055] 6. For treating weakness and flaccidity of the lower limbs in children: One ounce of Polygonatum sibiricum and one ounce of winter honey. Stew in boiling water and drink. (From "Min Dong Materia Medica")

[0056] 7. For treating thirst due to stomach heat: Six qian of Polygonatum sibiricum, five qian each of Rehmannia glutinosa and Dioscorea opposita, and four qian each of Trichosanthes kirilowii and Ophiopogon japonicus. Decoct in water and take orally. (From *Shandong Handbook of Traditional Chinese Medicine*)

[0057] 8. For treating eye ailments, replenishing liver qi, and improving eyesight: One pound of turnip seeds (washed clean with water), two pounds of polygonatum (steamed with turnip seeds nine times and dried in the sun). Grind the above ingredients into a fine powder. Take two qian (approximately 6 grams) on an empty stomach with rice porridge, and again after lunch and dinner with warm water. (Turnip Seed Powder from *Sheng Hui Fang*)

[0058] 9. For treating impaired vital energy, prolonged wind entering the meridians, leading to leprosy, nasal discoloration, and itchy, ulcerated skin: Take two catties of Polygonatum root (peeled and washed). Sun-dry until soft, then steam with millet rice in a steamer until two dou of rice are cooked. Take at any time. (From *Shengji Zonglu*)

[0059] 10. For treating pinworms: Stew 8 qian of Polygonatum sibiricum with 1 liang of rock sugar and consume. [From *Fujian Journal of Traditional Chinese Medicine*]

[0060] 11. Hyperlipidemia: 30g of Polygonatum sibiricum, 25g of hawthorn, and 15g of Polygonum multiflorum. Decoct in water and take one dose daily. This formula can also be used for the prevention and treatment of arteriosclerosis.

[0061] 12. Leukopenia: 2 parts Polygonatum sibiricum and 0.5 parts Ziziphus jujuba. Prepare a 100% decoction and take 20 ml orally three times a day.

[0062] 13. Diabetes: 15g of Polygonatum sibiricum, 15g of Dioscorea opposita, 12g each of Anemarrhena asphodeloides, Polygonatum odoratum, and Ophiopogon japonicus. Decoct in water and take orally. Effective for those with symptoms of thirst, excessive drinking, fatigue, and weakness due to deficiency of both Qi and Yin.

[0063] 14. For Lung Yin Deficiency: 30g of Polygonatum sibiricum and 50g of rock sugar. Wash the Polygonatum sibiricum and soak it in cold water for 3-4 hours. Put it in a pot, add rock sugar and an appropriate amount of water, bring to a boil over high heat, then simmer over low heat until the Polygonatum sibiricum is cooked and tender. Take twice a day, eating the Polygonatum sibiricum and drinking the soup. Suitable for cough with little phlegm, dry cough without phlegm, hemoptysis, etc., caused by Lung Yin Deficiency.

[0064] 15. For treating anemic, orthostatic, infectious, and unexplained hypotension: 30g each of Polygonatum sibiricum and Codonopsis pilosula, and 10g of prepared Glycyrrhiza uralensis. Decocted in water and taken once a day.

[0065] White peony root:

[0066] Meridian Tropism: Liver Meridian, Spleen Meridian.

[0067] Properties: Slightly cold in nature, bitter and sour in taste.

[0068] Indications: Soothes the liver and relieves pain, nourishes blood and regulates menstruation, astringes yin and stops sweating.

[0069] Pharmacological studies have shown that it possesses antispasmodic, analgesic, anti-inflammatory, and anti-myocardial ischemia-reducing pharmacological effects. White peony root has a wide range of applications, and some scholars believe that many of its effects are similar to ginseng. It has a central nervous system depressant effect, can reduce fever, and has sedative and hypnotic properties; it also has antispasmodic, anti-inflammatory, anti-ulcer, cellular and humoral immune-enhancing, vasodilatory, blood flow-increasing, hypoxia-tolerant, blood pressure-lowering, platelet aggregation-inhibiting, antibacterial, hepatoprotective, antimutagenic, antitumor, mast cell histamine release-inhibiting, and nerve junction depolarization effects.

[0070] 1. For treating dysentery with bloody stools, tenesmus, and bleeding, and regulating qi: Peony root 1 liang, Angelica sinensis 0.5 liang, Coptis chinensis 0.5 liang, Areca nut and Aucklandia lappa 2 qian, Licorice root 2 qian (fried), Rhubarb 3 qian, Scutellaria baicalensis 0.5 liang, Cinnamon bark 2.5 qian. Finely chop the above ingredients. Take 0.5 liang per dose, decocted in 2 cups of water until reduced to 1 cup, and taken warm after meals. (Peony Decoction from *Suwen Bingji Baoming Ji*)

[0071] 2. For treating chronic, persistent leukorrhea in women: Three taels of white peony root and half a tael of dried ginger. Finely chop, boil until yellow, then pound and sift. Take two qian (approximately 6 grams) on an empty stomach, mixed with drinking water, twice daily. (From *Guangli Fang*)

[0072] 3. For treating abdominal pain during pregnancy in women: Angelica sinensis 3 liang, Paeonia lactiflora 1 jin, Poria cocos 4 liang, Atractylodes macrocephala 4 liang, Alisma plantago-aquatica 0.5 jin, Ligusticum chuanxiong 0.5 jin (or 3 liang). Grind the above six ingredients into a powder. Take one spoonful, mix with wine, and take three times a day. (Angelica sinensis and Paeonia lactiflora powder from *Synopsis of Prescriptions of the Golden Chamber*)

[0073] 4. For treating postpartum abdominal pain due to blood stasis: Peony root 2 liang, cinnamon (outer bark removed), and licorice root (roasted) 1 liang each. Grind the three ingredients coarsely and sift. Take 3 qian (approximately 9 grams) per dose, decoct with one cup of water until reduced to seven-tenths, remove the dregs, and drink warm, at any time. (Peony Decoction from *Shengji Zonglu*)

[0074] Licorice:

[0075] Meridian Tropism: It enters the Heart, Lung, Spleen, and Stomach meridians.

[0076] Its properties are: sweet and neutral.

[0077] Indications: Tonifies the spleen and replenishes qi, clears heat and detoxifies, eliminates phlegm and relieves cough, alleviates spasms and pain, and harmonizes the effects of other medications. Used for spleen and stomach weakness, fatigue, palpitations, shortness of breath, cough with excessive phlegm, abdominal and limb spasms and pain, carbuncles and boils, and to alleviate the toxicity and harshness of other medications.

[0078] Pharmacological studies: ① Detoxification effect: Glycyrrhizin or its calcium salt has a strong detoxification effect, and it has a strong detoxification effect on diphtheria toxin and tetanus toxin. It also has a detoxification effect on some allergic diseases, experimental hepatitis in animals, pufferfish toxin and snake venom. Its detoxification mechanism may be multifaceted, through physical and chemical precipitation, adsorption and binding, which enhances the liver's detoxification function. The hydrolysis product of glycyrrhizin, glucuronic acid, is also an effective component for detoxification.

[0079] ② Anti-inflammatory and anti-allergic effects: Glycyrrhetinic acid has inhibitory effects on cotton pellet granuloma, formaldehyde-induced edema, tuberculin reaction, and subcutaneous granulomatous inflammation in rats; ammonium glycyrrhizate and sodium glycyrrhetinic acid can effectively affect the exudative and proliferative phases of subcutaneous granulomatous inflammation, and their effects are weaker than or close to those of cortisone; among various preparations of glycyrrhizic acid, succinate has the highest anti-inflammatory activity, but it is also more toxic; the mechanism of licorice's anti-inflammatory and anti-allergic effects has not been fully elucidated.

[0080] ③ Licorice has expectorant properties, promoting secretions in the throat and bronchi, making phlegm easier to cough up. Glycyrrhizic acid derivatives have significant antitussive effects on experimental coughs in guinea pigs and cats.

[0081] ④ Various preparations of licorice have a significant inhibitory effect on experimental gastric ulcers in rats. The aqueous extract of licorice has a protective effect on the gastric mucosa and can treat gastric ulcers. According to clinical and pharmacological research, the aqueous extract of licorice can increase the "hexosamine" content in gastric mucosal cells, thus protecting the gastric mucosa from damage. Regarding its effect on gastric juice secretion: after oral administration of licorice fluid extract, it can adsorb gastric acid, thus reducing gastric acid concentration, but it also exerts its effect after absorption; it also has an inhibitory effect on basal secretion.

[0082] ⑤ Antispasmodic: Licorice decoction and fluid extract have inhibitory effects on isolated animal intestines and antispasmodic effects on intestinal spasms induced by acetylcholine, barium chloride, histamine, etc. Licorice has a relaxant effect on isolated animal intestines and in vivo stomachs.

[0083] ⑥ Licorice significantly reduced liver degeneration and necrosis in experimentally induced liver injury in animals. The content of liver glycogen and ribonucleic acid accumulated in hepatocytes was mostly restored or close to normal, and the serum alanine aminotransferase activity was significantly reduced, indicating that licorice has an anti-liver injury effect.

[0084] ⑦ Adrenocortical hormone-like effects: Licorice can reduce urine output and sodium excretion, increase potassium excretion, raise blood sodium levels, lower blood calcium levels, and cause atrophy of the glomerular zona of the adrenal cortex in various animals. Licorice can increase the excretion of free 17-hydroxycorticosteroids in urine and decrease bound 17-hydroxycorticosteroids. Small doses may result in thymic atrophy, increased adrenal gland weight, widening of the fasciculus layer, and decreased vitamin C content in the adrenal glands. Licorice can significantly enhance and prolong the effects of cortisone. Regarding the mechanism of licorice's adrenocortical hormone-like effects, some believe that glycyrrhetinic acid has a similar chemical structure and similar effects to adrenocortical hormones, constituting a direct effect; others believe it is an indirect effect, where glycyrrhetinic acid inhibits the destruction of adrenocortical steroids in the body, thus increasing the blood corticosteroid content and exhibiting a more pronounced adrenocortical hormone-like effect. Licorice has an antagonistic effect on acetylcholine and can enhance the cardiotonic effect of adrenaline.

[0085] ⑧ Anti-cancer effects: Glycyrrhetinic acid has an inhibitory effect on experimental myeloma and ascites hepatoma in rats. It also has an inhibitory effect on Ehrlich ascites carcinoma in mice.

[0086] 1. The *Shennong Bencao Jing* states: "It treats cold and heat pathogens in the five viscera and six bowels, strengthens tendons and bones, promotes muscle growth, increases strength, treats wounds and swelling, and detoxifies."

[0087] 2. *Bielu* states: "It warms the middle burner and lowers qi, relieves restlessness and shortness of breath, treats cough caused by internal organ damage, quenches thirst, unblocks meridians, promotes blood circulation, and detoxifies various poisons."

[0088] 3. *Treatise on the Properties of Medicinal Herbs*: "It treats cold pain in the abdomen, epilepsy, and abdominal distension; it nourishes the five internal organs; it counteracts the toxicity of various drugs; it nourishes kidney qi and prevents impotence; it treats women's blood stasis and lower back pain; it is used when there is deficiency and excessive heat."

[0089] 4. *Rihuazi Materia Medica*: "It calms the soul and stabilizes the spirit. It replenishes the five weaknesses and seven injuries, treats all kinds of deficiency, palpitations, restlessness, and forgetfulness. It opens the nine orifices, benefits the hundred meridians, nourishes essence and qi, strengthens muscles and bones, and relieves cold and heat."

[0090] 5. "The Pearl Pouch": "Nourishes blood and stomach."

[0091] 6. *Tangye Bencao* (Compendium of Decoctions and Materia Medica): "It treats purulent and bloody pulmonary tuberculosis and can be used as an emetic; it eliminates five types of sores and carbuncles, with the same effect as Astragalus membranaceus."

[0092] 7. The Compendium of Materia Medica states: "It relieves infantile fetal toxins, infantile convulsions, reduces fever, and stops pain."

[0093] 8. *Illustrated Handbook of Chinese Medicinal Plants*: "Treats peptic ulcers and jaundice."

[0094] niacin:

[0095] Niacin, also known as vitamin B3 or vitamin PP, is heat-resistant and can sublimate. It is also called nicotinic acid or anti-pellagra factor. In the human body, it also contains its derivative, nicotinamide. It is one of the 13 essential vitamins for the human body, a water-soluble vitamin belonging to the B vitamin group. Niacin is converted into nicotinamide in the body. Nicotinamide is a component of coenzyme I and coenzyme II, participating in lipid metabolism, the oxidation process of tissue respiration, and the anaerobic breakdown of carbohydrates.

[0096] Niacin can affect cholesterol transport in the blood by inhibiting the synthesis of low-density lipoprotein, and high doses can lower serum cholesterol and triglyceride concentrations. Niacin also has a vasodilatory effect on peripheral blood vessels. Its main function is to treat hyperlipidemia, as it can dilate blood vessels. It can also be used to treat niacin deficiency diseases such as rough skin, optic nerve atrophy, malnutrition, retinal artery occlusion, and senile pruritus.

[0097] Propylene glycol:

[0098] Propylene glycol in cattle feed can be used as an energy source, increasing the energy density of the feed and thus promoting the growth and development of cattle. At the same time, propylene glycol can inhibit the growth of Gram-negative bacteria (such as Escherichia coli), reducing the risk of gastrointestinal diseases during feeding. Furthermore, adding propylene glycol can increase the number of beneficial bacteria (such as lactic acid bacteria) in the rumen, promoting digestion and absorption in cattle. Currently, the main method for preventing ketosis in dairy cows is glucose supplementation to combat ketosis, and propylene glycol, as a precursor to rumen propionate, can be rapidly absorbed as a precursor to gluconeogenesis and has begun to be widely used in intensive cattle farms.

[0099] Sodium fructose diphosphate:

[0100] Exogenous fructose-1,5-bisphosphate sodium can increase the intracellular concentrations of adenosine triphosphate (ATP) and creatine phosphate by activating the activities of phosphofructokinase and pyruvate kinase, promoting potassium ion influx, which is beneficial for cellular energy metabolism and glucose utilization under ischemic and hypoxic conditions, thereby reducing damage to ischemic myocardium. Fructose-1,5-bisphosphate sodium has the following effects:

[0101] 1. Improves brain function

[0102] Sodium fructose diphosphate can increase the utilization of glucose and amino acids in the brain, improve the energy supply to nerve cells, and thus improve brain function. It enhances cognitive abilities and memory by increasing brain energy levels.

[0103] 2. Relieve fatigue

[0104] Sodium fructose diphosphate can accelerate the regeneration of adenosine triphosphate in muscles and improve the body's ability to clear metabolic products such as lactic acid, thereby reducing fatigue. It is suitable for situations where fatigue is felt after prolonged mental or physical activity.

[0105] 3. Enhance exercise endurance

[0106] Sodium fructose diphosphate can promote muscle glycogen synthesis, improve muscle oxygen utilization, and prolong exercise time. Athletes can take it before competition to improve physical performance.

[0107] 4. Promotes liver repair

[0108] Sodium fructose diphosphate can stimulate hepatocyte regeneration and accelerate the repair process of damaged tissue. For patients with chronic liver disease or alcoholic liver damage, this medication helps promote the liver's recovery to a healthy state.

[0109] 5. Regulates lipid metabolism

[0110] Sodium fructose diphosphate can lower low-density lipoprotein cholesterol and raise high-density lipoprotein cholesterol, thereby affecting lipid metabolism. It can be used as an adjunct treatment for hyperlipidemia and related cardiovascular diseases.

[0111] Compared with the prior art, the advantages of the present invention are as follows:

[0112] 1. The oral liquid of this invention comprises compound traditional Chinese medicine, vitamins, energy source, and nutritional supplements. Taking into account multiple dimensions such as etiology, symptoms, and treatment plans, this oral liquid can prevent and treat ketosis, fatty liver, and liver damage in dairy cows, while comprehensively improving the physical condition of newborn cattle, enhancing immunity, improving physical indicators and reproductive performance, and increasing economic benefits.

[0113] 2. The compound traditional Chinese medicine in the oral liquid of this invention includes Artemisia capillaris, Gardenia jasminoides, Bupleurum chinense, Polygonatum sibiricum, Paeonia lactiflora, and Glycyrrhiza uralensis. These herbs are found in various herbal classics and are safe and effective. This compound traditional Chinese medicine addresses the etiology of energy metabolism disorders in peripartum dairy cows, aiming to combine prevention and treatment, addressing both the symptoms and the root cause, and regulating the body's constitution through drug combination. Artemisia capillaris and Gardenia jasminoides are the principal herbs, protecting the liver and gallbladder, clearing heat and dampness, purging fire and relieving irritability; Bupleurum chinense is the assistant herb, harmonizing the exterior and interior, controlling blood sugar and lowering lipids, and reducing gastrointestinal irritation; Polygonatum sibiricum and Paeonia lactiflora are the adjuvant herbs, with mild medicinal properties, replenishing qi and nourishing yin, and enhancing immunity; Glycyrrhiza uralensis is the guiding herb, sweet and neutral in nature, tonifying and detoxifying, and harmonizing the other herbs. The combination of these herbs enhances their effects of clearing heat and dampness, protecting the liver and gallbladder, and working together to protect the liver, lower lipids, harmonize the stomach, and promote digestion.

[0114] 3. The vitamin in the oral liquid of this invention refers to niacin, a component of coenzyme I and coenzyme II, which participates in lipid metabolism, the oxidation process of tissue respiration, and the anaerobic decomposition of carbohydrates. Dairy cows have a higher requirement for niacin in the early stages of lactation than at other stages; failure to supplement in time will lead to reduced milk production and an increased risk of ketosis. Combining niacin with the above-mentioned compound traditional Chinese medicine can effectively prevent and improve symptoms such as hyperlipidemia and malnutrition in dairy cows.

[0115] 4. The propylene glycol in the oral liquid of this invention has the following functions: 1) It participates in regulating the balance of carbohydrate and lipid metabolism in dairy cows and alleviates the negative energy balance after calving; 2) It increases the protein content in milk and increases milk production; 3) It reduces the probability of dairy cows suffering from ketosis and fatty liver; 4) It improves the quality of dairy cow eggs and ovarian function and increases the reproductive rate.

[0116] 5. The fructose-1,6-bisphosphate sodium in the oral solution of this invention can activate the activity of phosphofructokinase and pyruvate kinase, increasing the concentration of intracellular adenosine triphosphate and creatine phosphate, promoting potassium ion influx, which is beneficial for cellular energy metabolism and glucose utilization under ischemic and hypoxic conditions. It not only reduces damage to ischemic myocardium but also stimulates hepatocyte regeneration and promotes liver repair. Combining fructose-1,6-bisphosphate sodium with compound traditional Chinese medicine, nicotinic acid, and propylene glycol provides liver protection and lipid reduction, combining prevention and treatment, which helps the recovery of damaged hepatocytes and restores dairy cows to a healthy state.

[0117] 6. The oral liquid of this invention for preventing and treating peripartum energy metabolism disorders in dairy cows is composed of compound traditional Chinese medicine, vitamins, energy sources, and nutrients. It has a reasonable combination, clear efficacy, and is suitable for large-scale production. It fundamentally prevents and treats ketosis, fatty liver, and liver damage in dairy cows, improves physical indicators and reproductive performance, and overcomes the problems of high incidence of peripartum energy metabolism disorders in dairy cows, which greatly endanger the health and production performance of dairy cows, and the inability of existing drugs to treat both the symptoms and the root cause, and to combine prevention and treatment. It has the advantages of good efficacy, high safety, and low cost. Detailed Implementation

[0118] The following embodiments are used to illustrate the present invention, but are not intended to limit the scope of protection of the present invention. Unless otherwise specified, the technical means used in the embodiments are conventional means well known to those skilled in the art. Unless otherwise specified, the test methods in the following embodiments are conventional methods. Example 1

[0119] The oral liquid for preventing and treating peripartum energy metabolism disorders in dairy cows is made from the following components, by weight: 210 parts Artemisia capillaris, 160 parts Gardenia jasminoides, 100 parts Bupleurum chinense, 60 parts Polygonatum sibiricum, 60 parts Paeonia lactiflora, 20 parts Glycyrrhiza uralensis, 2 parts Nicotinic acid, 220 parts Propylene glycol, 2 parts Sodium fructose diphosphate, and 300 parts purified water.

[0120] The preparation method of the above oral liquid is as follows: take Artemisia capillaris, Gardenia jasminoides, Bupleurum chinense, Polygonatum sibiricum, Paeonia lactiflora, and Glycyrrhiza uralensis, add 15 times the amount of water and soak for 2 hours, decoct twice, each time for 3 hours, combine the filtrates, centrifuge, concentrate the centrifuged filtrate to a relative density of 1.02~1.05g / mL; add nicotinic acid, propylene glycol, fructose diphosphate sodium, and purified water, stir evenly, filter, dispense, sterilize, and obtain the oral liquid. Example 2

[0121] The oral liquid for preventing and treating peripartum energy metabolism disorders in dairy cows is made from the following components, by weight: 230 parts Artemisia capillaris, 180 parts Gardenia jasminoides, 110 parts Bupleurum chinense, 80 parts Polygonatum sibiricum, 70 parts Paeonia lactiflora, 30 parts Glycyrrhiza uralensis, 5 parts Nicotinic acid, 280 parts Propylene glycol, 3 parts Sodium fructose diphosphate, and 250 parts purified water.

[0122] The preparation method of the above oral liquid is as follows: take Artemisia capillaris, Gardenia jasminoides, Bupleurum chinense, Polygonatum sibiricum, Paeonia lactiflora, and Glycyrrhiza uralensis, add 10 times the amount of water and soak for 1 hour, decoct twice, each time for 4 hours, combine the filtrates, centrifuge, concentrate the centrifuged filtrate to a relative density of 1.02~1.05 g / mL; add nicotinic acid, propylene glycol, fructose diphosphate sodium, and purified water, stir evenly, filter, dispense, sterilize, and obtain the oral liquid. Example 3

[0123] The oral liquid for preventing and treating peripartum energy metabolism disorders in dairy cows is made from the following components, by weight: 280 parts Artemisia capillaris, 170 parts Gardenia jasminoides, 130 parts Bupleurum chinense, 70 parts Polygonatum sibiricum, 80 parts Paeonia lactiflora, 30 parts Glycyrrhiza uralensis, 6 parts Nicotinic acid, 260 parts Propylene glycol, 5 parts Sodium fructose diphosphate, and 350 parts purified water.

[0124] The preparation method of the above oral liquid is as follows: take Artemisia capillaris, Gardenia jasminoides, Bupleurum chinense, Polygonatum sibiricum, Paeonia lactiflora, and Glycyrrhiza uralensis, add 20 times the amount of water and soak for 3 hours, decoct twice, 2 hours each time, combine the filtrates, centrifuge, concentrate the centrifuged filtrate to a relative density of 1.02~1.05g / mL; add nicotinic acid, propylene glycol, fructose diphosphate sodium, and purified water, stir evenly, filter, dispense, sterilize, and obtain the oral liquid. Example 4

[0125] The oral liquid for preventing and treating peripartum energy metabolism disorders in dairy cows is made from the following components, by weight: 260 parts Artemisia capillaris, 160 parts Gardenia jasminoides, 135 parts Bupleurum chinense, 90 parts Polygonatum sibiricum, 75 parts Paeonia lactiflora, 35 parts Glycyrrhiza uralensis, 7 parts Nicotinic acid, 270 parts Propylene glycol, 8 parts Sodium fructose diphosphate, and 220 parts purified water.

[0126] The preparation method in this embodiment is the same as in Embodiment 1. Comparative Example 1

[0127] Compared with Example 4, the weight of the compound Chinese herbal medicine Artemisia capillaris was reduced from 260 to 30, while the rest remained the same as in Example 4. Comparative Example 2

[0128] Compared with Example 4, the weight of the compound Chinese herbal medicine Bupleurum was reduced from 135 to 10, while the rest remained the same as in Example 4. Comparative Example 3

[0129] Compared with Example 4, the weight of nicotinic acid was reduced from 7 to 0.5, while the rest remained the same as in Example 4. Comparative Example 4

[0130] Compared to Example 4, the weight of propylene glycol was reduced from 260 to 10, while everything else remained the same as in Example 4.

[0131] Experimental Example 1: Prevention Effect Test.

[0132] Select a relatively large dairy farm with 10,000 cows, and select 120 healthy dairy cows with similar age, parity, body condition and expected calving date. They are randomly divided into 6 groups (experimental group, control group 1, control group 2, control group 3, control group 4, and blank group), with 20 cows in each group.

[0133] Experimental group: Each cow was fed 200 mL of the oral liquid prepared in Example 4 daily for three weeks before calving, and added twice a week.

[0134] Control group 1: Each cow was fed 200 mL of the oral liquid prepared in control group 1 daily for three weeks before calving, and added twice a week.

[0135] Control group 2: Each cow was fed 200 mL of the oral liquid prepared in control group 2 daily for three weeks before calving, and added twice a week.

[0136] Control group 3: Each cow was fed 200 mL of the oral liquid prepared in control group 3 daily for three weeks before calving, and added twice a week.

[0137] Control group 4: Each cow was fed 200 mL of the oral liquid prepared in control group 4 daily for three weeks before calving, and added twice a week.

[0138] Control group: fed with a regular daily ration.

[0139] Blood levels of GLU (glucose), NEFA (free fatty acids), BHBA (β-hydroxybutyrate), and ALT (alanine aminotransferase) were measured at 3, 7, 14, and 21 days postpartum, and the data were analyzed. The specific results are as follows:

[0140] 3d 7d 14d 21d experimental group 3.16±0.18 2.95±0.15 2.98±0.17 3.12±0.19 Comparison Group 1 3.07±0.19 2.85±0.12 2.87±0.14 3.03±0.15 Comparison Group 2 3.06±0.16 2.83±0.10 2.82±0.13 3.05±0.18 Comparison Group 3 3.02±0.15 2.81±0.11 2.83±0.14 2.99±0.12 Comparison Group 4 3.03±0.17 2.95±0.15 2.98±0.17 3.12±0.19 Blank group 2.92±0.11 2.87±0.16 2.88±0.15 2.93±0.12

[0141] Table 1. Blood GLU levels (mmol / L)

[0142] 3d 7d 14d 21d experimental group 0.54±0.06 0.47±0.05 0.33±0.07 0.29±0.05 Comparison Group 1 0.63±0.05 0.52±0.06 0.47±0.05 0.37±0.05 Comparison Group 2 0.65±0.06 0.54±0.07 0.49±0.08 0.35±0.05 Comparison Group 3 0.68±0.07 0.51±0.05 0.45±0.07 0.33±0.05 Comparison Group 4 0.59±0.05 0.55±0.06 0.44±0.05 0.36±0.05 Blank group 0.72±0.04 0.67±0.08 0.42±0.05 0.39±0.06

[0143] Table 2. NEFA content in blood (unit: mmol / L)

[0144] 3d 7d 14d 21d experimental group 0.86±0.06 1.01±0.07 0.95±0.08 0.89±0.05 Comparison Group 1 0.93±0.08 1.18±0.09 1.02±0.05 0.92±0.07 Comparison Group 2 0.95±0.07 1.22±0.10 1.10±0.06 0.98±0.08 Comparison Group 3 0.91±0.05 1.20±0.05 1.06±0.09 0.95±0.09 Comparison Group 4 0.92±0.07 1.19±0.08 1.12±0.08 0.96±0.10 Blank group 1.02±0.09 1.35±0.10 1.18±0.05 1.04±0.07

[0145] Table 3. Blood BHBA levels (mmol / L)

[0146] 3d 7d 14d 21d experimental group 23.08±2.6 23.85±2.5 22.33±2.8 21.15±2.7 Comparison Group 1 25.55±2.9 26.58±3.0 25.89±2.5 23.29±2.6 Comparison Group 2 25.78±2.7 26.71±2.8 25.62±2.7 23.41±2.5 Comparison Group 3 25.15±2.8 26.24±2.9 25.81±2.6 23.19±3.0 Comparison Group 4 25.28±2.5 26.39±2.6 25.73±2.8 23.52±2.9 Blank group 27.42±2.2 29.77±2.3 29.11±2.5 25.19±3.0

[0147] Table 4. Blood ALT levels (unit: U / L)

[0148] Grouping Incidence rate (%) experimental group 10 Comparison Group 1 25 Comparison Group 2 20 Comparison Group 3 20 Comparison Group 4 25 Blank group 40

[0149] Table 5. Incidence of postpartum ketosis (%)

[0150] As can be seen from Tables 1-5, the oral liquid of the present invention can effectively prevent hyperlipidemia, hyperketosis and liver damage in dairy cows, and reduce the incidence of ketosis.

[0151] Experimental Example 2: Treatment Efficacy Trial.

[0152] Choose a relatively large dairy farm with 10,000 cows, select 60 cows with ketosis of similar age, parity, body condition and expected calving date, and randomly divide them into 6 groups (experimental group, control group 1, control group 2, control group 3, control group 4, and blank group), with 10 cows in each group.

[0153] Experimental group: Each cow was fed 200 mL of the oral liquid prepared in Example 4 daily for 7 consecutive days.

[0154] Control group 1: Each cow was fed 200 mL of the oral solution prepared in control group 1 daily for 7 consecutive days.

[0155] Control group 2: Each cow was fed 200 mL of the oral solution prepared in control group 2 daily for 7 consecutive days.

[0156] Control group 3: Each cow was fed 200 mL of the oral solution prepared in control group 3 daily for 7 consecutive days.

[0157] Control group 4: Each cow was fed 200 mL of the oral solution prepared in control group 4 daily for 7 consecutive days.

[0158] Control group: fed with a regular daily ration.

[0159] After 7 consecutive days of feeding, blood levels of GLU (glucose), NEFA (free fatty acids), BHBA (β-hydroxybutyrate), and ALT (alanine aminotransferase) were measured and analyzed. The specific results are as follows:

[0160] GLU content (mmol / L) NEFA content (mmol / L) BHBA content (mmol / L) ALT content (U / L) experimental group 3.19±0.15 0.65±0.05 1.15±0.05 21.11±1.8 Comparison Group 1 3.07±0.16 0.72±0.04 1.10±0.04 25.87±1.7 Comparison Group 2 3.12±0.14 0.70±0.05 1.08±0.06 26.12±1.5 Comparison Group 3 3.06±0.17 0.73±0.06 1.05±0.05 25.78±2.0 Comparison Group 4 3.10±0.15 0.75±0.05 1.09±0.07 25.90±1.9 Blank group 2.88±0.18 0.81±0.07 1.40±0.04 28.82±2.3

[0161] Table 6. Blood Biochemical Indicators of Dairy Cows

[0162] Grouping Recovery rate (%) experimental group 80 Comparison Group 1 50 Comparison Group 2 40 Comparison Group 3 60 Comparison Group 4 50 Blank group 10

[0163] Table 7. Postpartum ketosis recovery rate (%)

[0164] As can be seen from Tables 6-7, the oral liquid of the present invention can effectively reverse hyperlipidemia, hyperketemia and liver damage in dairy cows, correct negative energy balance and treat ketosis in dairy cows.

[0165] Experiment Example 3: Reproductive Performance Test.

[0166] Select a relatively large dairy farm with 10,000 cows, and select 120 healthy dairy cows with similar age, parity, body condition and expected calving date. They are randomly divided into 6 groups (experimental group, control group 1, control group 2, control group 3, control group 4, and blank group), with 20 cows in each group.

[0167] Experimental group: Each cow was fed 200 mL of the oral liquid prepared in Example 4 daily after calving, twice a week for 4 consecutive weeks.

[0168] Control group 1: Each cow was fed 200 mL of the oral solution prepared in control group 1 daily after calving, twice a week for 4 consecutive weeks.

[0169] Control group 2: Each cow was fed 200 mL of the oral solution prepared in control group 2 daily after calving, twice a week for 4 consecutive weeks.

[0170] Control group 3: Each cow was fed 200 mL of the oral solution prepared in control group 3 daily after calving, twice a week for 4 consecutive weeks.

[0171] Control group 4: Each cow was fed 200 mL of the oral solution prepared in control group 4 daily after calving, twice a week for 4 consecutive weeks.

[0172] Control group: fed with a regular daily ration.

[0173] After four consecutive weeks, postpartum reproductive performance was assessed, and the results are as follows:

[0174] Average time to first insemination postpartum (days) Mating index (times) First estrus conception rate (%) experimental group 62 1.8 45 Comparison Group 1 68 2.4 40 Comparison Group 2 66 2.3 35 Comparison Group 3 63 2.5 40 Comparison Group 4 65 2.2 40 Blank group 72 2.9 30

[0175] Table 8 Average postpartum reproductive performance of dairy cows

[0176] As can be seen from Table 8, the oral liquid of the present invention can significantly improve the reproductive performance of the body.

[0177] In summary, the oral liquid for preventing and treating periparturient dairy cow energy metabolism disorders described in this invention can comprehensively improve the physical condition of newborn cows, enhance immunity, improve physical indicators and reproductive performance, and increase economic benefits while preventing and treating ketosis, fatty liver and liver damage in dairy cows.

[0178] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. An oral liquid for preventing and treating perinatal dairy cow energy metabolism disorder disease, characterized in that, the oral liquid comprises the following components: It is made from the following components, by weight: Artemisia capillaris 200-300 parts, Gardenia jasminoides 150-200 parts, Bupleurum chinense 100-150 parts, Polygonatum sibiricum 50-100 parts, Paeonia lactiflora 50-100 parts, Glycyrrhiza uralensis 10-50 parts, Nicotinic acid 1-10 parts, Propylene glycol 200-300 parts, Sodium fructose diphosphate 1-10 parts, and purified water 200-400 parts. ​ 2. The oral liquid according to claim 1, characterized in that, The preparation method is as follows: Take Artemisia capillaris, Gardenia jasminoides, Bupleurum chinense, Polygonatum sibiricum, Paeonia lactiflora, and Glycyrrhiza uralensis, add 10-20 times the amount of water and soak for 1-3 hours, decoct twice, each time for 2-4 hours, combine the filtrates, centrifuge, concentrate the centrifuged filtrate to a relative density of 1.02-1.05 g / mL; add nicotinic acid, propylene glycol, fructose diphosphate sodium, and purified water, stir evenly, filter, dispense, sterilize, and obtain oral liquid.