Storage device for liquid preparation drug production

Abstract

The present invention relates to the technical field of liquid medicine production and storage, and in particular to a storage device for the production of liquid preparation drugs, which is mainly suitable for products such as Acanthopanax Brain Spirit Mixture, Deer Antler and Ginseng Whip Wine, Ginkgo Leaf Drops and other liquid preparations. The present invention includes a storage container, a filling device and a liquid discharge device. The upper part of the storage container is connected to the filling device through a pipeline, and the lower part of the storage container is connected to the liquid discharge device through a pipeline. A stirring device is installed in the storage container, and a sampling device is installed and connected on the pipeline connected to the filling device and the storage container. The storage, input and output processes are all carried out in a closed container to reduce contact with air. The stirring device is used to continuously stir the medicine stored in the storage container to reduce precipitation and condensation. The supporting device is used to support and fix the storage container. The sampling device is used to sample the medicine during the production process, which is convenient for timely control of the quality of the medicine by detecting the sample.

Description

Technical Field

[0001] The present invention relates to the technical field of liquid medicine production and storage, and in particular to a storage device for liquid preparation drug production, which is mainly suitable for products such as Acanthopanax Senticosus Brain Mixture, Deer Antler and Ginseng Whip Wine, Ginkgo Leaf Drops and other liquid preparations. Background Art

[0002] According to the requirements of GMP pharmaceutical production quality management standards, the pharmaceutical production process must ensure the consistency of product quality, that is, the production and processing of drugs must be consistently carried out using production processes that have been verified to achieve consistency. In the production of pharmaceutical preparations, production materials such as raw materials, excipients and packaging materials are the basic content of the product production process and the basic elements of product quality. They directly or indirectly affect the stability of the quality of intermediate products and final products. If drugs that meet quality standards are to be consistently produced, strengthening the storage management of production materials is one of the important contents of pharmaceutical production quality management.

[0003] In the production process of Chinese patent medicine preparations, such as Acanthopanax Brain Mixture, Deer Antler and Ginseng Whip Wine, Ginkgo Leaf Drops, etc., the raw materials are various Chinese medicine formulas. The processing process includes using the decoction concentrate of the Chinese medicine compound or the Chinese medicine extract as a water solvent to prepare a clear liquid preparation for oral administration. It has a wide range of uses. It can be used to treat diseases and is also a nutrition, health care, and tonic. After entering the gastrointestinal tract, it is directly absorbed and exhibits a faster effect. Therefore, the varieties produced have developed from a few at the beginning to nearly a thousand now and there is a trend of continued increase.

[0004] The storage of drugs during the production process requires suitable temperature and a clean environment. In the relevant drug production and storage equipment technology, it is difficult to avoid the contact of drugs with air during production. They are easily contaminated by pollutants in the air and their properties change due to the influence of air temperature. Closed production does not control the quality of the material production process in a timely manner, and the impurities and sediments generated cannot be effectively removed. Summary of the invention

[0005] In order to solve the environmental control and reduce pollution contact in the production process of oral preparations of drugs such as Ciwujia Naoling Mixture, Deer Antler and Ginseng Whip Wine, and Ginkgo Leaf Drops, and effectively control the quality of drugs, the present invention provides a storage device for the production of liquid preparations.

[0006] The present invention provides a storage device for liquid preparation drug production using the following technical solution:

[0007] A storage device for the production of liquid preparation drugs, comprising a storage container, a filling device and a liquid discharge device, wherein the upper portion of the storage container is connected to the filling device via a pipeline, and the lower portion of the storage container is connected to the liquid discharge device via a pipeline, a stirring device is installed in the storage container, and the stirring device is always in a rotating state in the storage container, a supporting device is provided on the outer surface of the storage container, and a sampling device is installed and connected to the pipeline connecting the filling device and the storage container, and the sampling device automatically extracts a portion of the drug liquid from the pipeline connecting the filling device and the storage container as a preserved sample at a time interval.

[0008] Storage containers are used to store medicines in production and protect the medicine solutions from being contaminated by pollutants in the air. Filling equipment is used to automatically fill medicine solutions or liquid raw materials into storage containers. Discharge equipment is used to extract medicine solutions from storage containers and automatically transport them to other production equipment or fill them into bottles. The storage, input and output processes are all carried out in a closed container to reduce contact with air. Stirring equipment is used to continuously stir the medicines stored in the storage container to reduce precipitation and condensation. Support devices are used to support and fix storage containers. Sampling equipment is used to sample medicines during the production process, which is convenient for timely control of drug quality by testing samples.

[0009] Furthermore, the storage container includes a container shell, which is a closed metal container. The outside of the container shell is wrapped with an insulation layer, which is made of insulation material. A cooling layer is arranged between the insulation layer and the container shell, and the cooling layer is externally connected to a heat exchange device.

[0010] The container shell is a closed metal container, which is conducive to sealing and preserving medicines to reduce pollution. The insulation layer is conducive to isolating the influence of external ambient temperature. The cooling layer adjusts the production and storage temperature of medicines by active cooling, keeping the production of medicines at the most reasonable temperature.

[0011] Furthermore, the container shell has a liquid inlet near the top end, and a liquid inlet filter is installed at the liquid inlet; the container shell has a liquid discharge port near the bottom end, and a liquid discharge filter is installed at the liquid discharge port.

[0012] The liquid inlet is opened at the top to facilitate the injection of the medicine into the container shell and avoid backflow. The liquid inlet filter is used to filter large impurities in the medicine to avoid affecting the quality of the medicine. The discharge port is opened at the bottom of the container to facilitate the automatic discharge of the liquid from the container shell by gravity. The discharge filter is used to filter large flocculants in the medicine to avoid affecting the product quality.

[0013] Furthermore, the filling equipment is connected to the liquid inlet through a pipeline, and then connected to the container shell. The filling equipment includes a filling pump. The liquid outlet of the filling pump is connected to the liquid inlet through a pipeline. A liquid inlet check valve is installed on the pipeline connecting the filling pump and the liquid inlet. The liquid inlet check valve only allows the medicine liquid to enter the container shell in one direction. A liquid inlet flow monitor is also installed on the pipeline connecting the filling pump and the liquid inlet. The liquid inlet flow monitor extends into the pipeline and detects the cumulative amount of medicine liquid filled. A liquid inlet stop valve is also installed on the pipeline connecting the filling pump and the liquid inlet. The liquid inlet stop valve is connected in series with the liquid inlet check valve. A reflux pipe is connected between the liquid outlet and the liquid inlet of the filling pump. A reflux valve is installed on the reflux pipe. The reflux valve is a pressure control valve.

[0014] The filling pump is used to automatically fill the medicine or liquid raw materials into the container shell. The liquid inlet one-way valve is used to reduce the backflow of the medicine, avoid secondary contamination, and ensure the hygiene of the medicine filled into the container shell. The liquid inlet flow monitor is used to monitor the amount of medicine filled, avoid excessive filling of the medicine and overflow, and effectively protect the enclosed space of the container shell. The liquid inlet stop valve is used to control the filling and stop the filling. The reflux valve and reflux pipe are used to relieve the delivery pressure at the moment of closing the liquid inlet stop valve, to avoid delivery pressure shock and damage to the filling equipment.

[0015] Furthermore, the drainage device is connected to the drainage port through a pipeline and is further connected to the container shell. The drainage device includes a drainage one-way valve, which is installed at the drainage port through a pipeline. The drainage one-way valve only allows the medicine to be discharged from the container shell in one direction. A drainage flow monitor is installed between the drainage one-way valve and the drainage port. The drainage flow monitor extends into the pipeline and detects the cumulative output of the medicine. A drainage stop valve is installed on one side of the drainage flow monitor. The drainage stop valve is connected in series with the drainage one-way valve. The drainage one-way valve is connected to a doser through a pipeline on the side away from the container shell. The doser includes a dispensing tube, a dosing tube and a filling needle. The dispensing tube is connected to multiple dosing tubes through a pipeline, and a filling needle is connected to the bottom of each of the dosing tubes.

[0016] The discharge check valve is used to control the direction of discharge and reduce the pollution caused by the backflow of discharge. The discharge flow monitor is used to monitor the amount of medicine flowing out of the container shell to facilitate the judgment of timely replenishment of medicine. The discharge stop valve is used to control and stop the discharge. The dosing device is used to quantitatively output the medicine and is used to load the quantitative tank into the medicine bottle. The dispensing tube evenly distributes the medicine into each quantitative tube, and the filling needle accurately fills the medicine in the quantitative tube into the medicine bottle.

[0017] Furthermore, a filling port and an exhaust port are opened at the top of the container shell, the filling port is connected to an air pump, a filling valve is installed on the pipeline connecting the air pump and the filling port, the air pump is externally connected to a nitrogen tank, and the exhaust port is connected to an exhaust valve.

[0018] The filling port and exhaust port are used to balance the air pressure inside the closed container shell, thereby ensuring the smooth filling and exhaust of the medicine into and out of the container shell. The filling valve and exhaust valve are used to control the input gas and the exhaust gas. The nitrogen tank is used to provide pure nitrogen to keep the gas that the medicine contacts clean and sterile.

[0019] Furthermore, the container shell has a plurality of observation ports on its side, the observation ports are arranged vertically and spaced apart, the observation ports are blocked by glass, a light shield is detachably mounted on the observation port, a slag discharge port is provided at the bottom end of the container shell, a plurality of sedimentation boxes are slidably mounted directly below the slag discharge port, the sedimentation boxes are cyclically slidably positioned directly below the slag discharge port, a cleaning port is provided on the container shell, the cleaning port is covered and closed by a closing cover, one side of the closing cover is swung and mounted on the container shell by a hinge, and the other side is detachably connected to the container shell by a lock.

[0020] The observation port is used to observe the state of the reagent in the container shell, the light shield is used to cover the observation port to prevent light from affecting some light-sensitive reagents and affecting the quality of the reagents, the slag discharge port is used to collect the sediment in the reagents, the sedimentation box is used to collect the sediment and clean it up in time, and the cleaning port is convenient for cleaning the inside of the container shell, which is conducive to recycling in the production of different reagents.

[0021] Furthermore, the stirring device includes a stirring brush and a stirring motor, the stirring brush being connected to the rotating main shaft of the stirring motor, the stirring brushes being arranged in a circle around the rotating main shaft of the stirring motor, the rotating main shaft of the stirring motor is also connected to a central prism of the stirring motor, a liquid scraper is slidably sleeved on the central prism, the liquid scraper floats on the surface of the medicine liquid and slides up and down along the central prism following the rise and fall of the medicine liquid, the cross-section of the central prism is polygonal and cooperates with the cross-section of the central through hole of the liquid scraper to achieve circumferential fixation, and a magnetic screen is fixedly arranged at the bottom of the stirring brush, and the magnetic screen contains a permanent magnetic material.

[0022] The stirring brush continuously stirs the medicine under the drive of the stirring motor, which is beneficial to reduce the precipitation or flocculation of effective substances in the medicine, thereby affecting the use effect of the medicine. The liquid scraper is used to stir the upper surface of the medicine to slow down the formation of condensation film on the surface of the medicine. The magnetic screen is used to absorb fine metal impurities in the medicine to improve the overall quality of the medicine.

[0023] Furthermore, the sampling device includes a sampling valve, one side of the sampling valve is connected to the pipeline of the filling equipment through a pipeline, and the other side is connected to the dropper through a pipeline, a sampling bottle is arranged directly below the dropper, and the sampling bottles are arranged at intervals on a sampling bottle rack, and the sampling bottle rack is driven by an intermittent motor to control intermittent swing, thereby driving the sampling bottles to be transferred to the bottom of the dropper in sequence, a sampling bottle sensor is installed on one side of the dropper, and a marking device is installed on the other side.

[0024] The sampling valve is used to control sampling, the dropper is used to pour the sampled medicine into the sampling bottle, the sampling bottle rack is used to hold the sampling bottle, and at the same time, the sampling bottle is controlled by the rotary motor to collect samples one by one. The marking device is used to mark the sampling bottle to facilitate the subsequent search for production batches and time. The sampling bottle sensor is used to sense the sampling bottle and remind the staff to replenish and replace the sampling bottle in time.

[0025] Furthermore, the supporting device includes a supporting frame and a hanging frame, wherein the supporting frame is installed at the bottom of the storage container and fixed on the ground, and the hanging frame is installed on the top of the storage container.

[0026] The lifting frame facilitates lifting the entire device to the installation location.

[0027] In summary, the present invention has the following beneficial technical effects:

[0028] 1. Storage containers are used to store medicines in production and protect the medicine solutions from being contaminated by pollutants in the air. Filling equipment is used to automatically fill medicine solutions or liquid raw materials into storage containers. Discharge equipment is used to extract medicine solutions from storage containers and automatically transport them to other production equipment or fill them into bottles. The storage, input and output processes are all carried out in a closed container to reduce contact with air. The stirring equipment is used to continuously stir the medicines stored in the storage container to reduce precipitation and condensation. The supporting device is used to support and fix the storage container. The sampling equipment is used to sample the medicines during the production process, which is convenient for timely control of drug quality by testing the samples.

[0029] 2. The container shell is a closed metal container, which is conducive to sealing and preserving the medicine to reduce pollution. The insulation layer is conducive to isolating the influence of the external ambient temperature. The cooling layer adjusts the production and storage temperature of the medicine by actively cooling down, keeping the production of the medicine at the most reasonable temperature.

[0030] 3. The liquid inlet is opened at the top to facilitate the injection of the agent into the container shell and avoid backflow. The liquid inlet filter is used to filter large impurities in the agent to avoid affecting the quality of the agent. The liquid discharge port is opened at the bottom of the container to facilitate the automatic discharge of the liquid from the container shell by gravity. The liquid discharge filter is used to filter large flocculants in the agent to avoid affecting the product quality.

[0031] 4. The filling pump is used to automatically fill the medicine or liquid raw materials into the container shell. The liquid inlet one-way valve is used to reduce the backflow of the medicine, avoid secondary pollution, and ensure the hygiene of the medicine filled into the container shell. The liquid inlet flow monitor is used to monitor the amount of medicine filled, avoid excessive filling of the medicine and overflow, and effectively protect the closed space of the container shell. The liquid inlet stop valve is used to control the filling and stop the filling. The reflux valve and reflux pipe are used to relieve the delivery pressure at the moment of closing the liquid inlet stop valve to avoid delivery pressure shock and damage to the filling equipment.

[0032] 5. The discharge check valve is used to control the discharge direction and reduce the pollution caused by the backflow of the discharge. The discharge flow monitor is used to monitor the amount of medicine flowing out of the container shell to facilitate the judgment and timely replenishment of the medicine. The discharge stop valve is used to control the discharge and stop the discharge. The dosing device is used to quantitatively output the medicine and is used to load the quantitative tank into the medicine bottle. The dispensing tube evenly distributes the medicine to each quantitative tube, and the filling needle accurately fills the medicine in the quantitative tube into the medicine bottle.

[0033] 6. The filling port and exhaust port are used to balance the air pressure inside the closed container shell, thereby ensuring the smooth filling and discharge of the medicine into and out of the container shell. The filling valve and exhaust valve are used to control the input gas and the exhaust gas. The nitrogen tank is used to provide pure nitrogen to keep the gas in contact with the medicine clean and sterile.

[0034] 7. The observation port is used to observe the state of the reagent in the container shell. The light shield is used to cover the observation port to prevent light from affecting some light-sensitive reagents and affecting the quality of the reagents. The slag discharge port is used to collect the sediment in the reagent. The sedimentation box is used to collect the sediment and clean it in time. The cleaning port is convenient for cleaning the inside of the container shell, which is conducive to recycling in the production of different reagents.

[0035] 8. The stirring brush continuously stirs the medicine under the drive of the stirring motor, which is beneficial to reduce the precipitation or flocculation of effective substances in the medicine, thereby affecting the use effect of the medicine. The liquid scraper is used to stir the upper surface of the medicine to slow down the formation of condensation film on the surface of the medicine. The magnetic screen is used to absorb fine metal impurities in the medicine to improve the overall quality of the medicine.

[0036] 9. The sampling valve is used to control sampling, the dropper is used to pour the sampled medicine into the sampling bottle, the sampling bottle rack is used to hold the sampling bottle, and the sampling bottle is controlled by the intermediate motor to collect samples one by one. The marking device is used to mark the sampling bottle to facilitate the subsequent search for the production batch and time. The sampling bottle sensor is used to sense the sampling bottle to remind the staff to replenish and replace the sampling bottle in time. The lifting frame is convenient for lifting the entire equipment to the installation location. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 This is a schematic diagram of the external structure connection of the present invention;

[0038] Figure 2 for Figure 1 A magnified schematic diagram of point A;

[0039] Figure 3 It is a schematic diagram of another perspective of the figure;

[0040] Figure 4 It is a schematic diagram of the internal structure cut at the center plane of the present invention;

[0041] Figure 5 for Figure 4 An enlarged schematic diagram of point B;

[0042] Figure 6 It is a partial enlarged schematic diagram of the liquid inlet of the present invention;

[0043] Figure 7 It is a partial enlarged schematic diagram of the liquid discharge port of the present invention.

[0044] Description of reference numerals:

[0045] 1. storage container, 11. container shell, 111. insulation layer, 112. cooling layer, 12. liquid inlet, 121. liquid inlet filter, 13. liquid discharge port, 131. liquid discharge filter, 14. observation port, 141. light shield, 15. air filling port, 151. air filling valve, 152. air pump, 16. exhaust port, 161. exhaust valve, 17. slag discharge port, 171. sedimentation box, 18. cleaning port, 181. closing cover;

[0046] 2. Filling equipment, 21. Filling pump, 22. Liquid inlet check valve, 221. Reflux valve, 222. Reflux pipe, 23. Liquid inlet flow monitor, 231. Liquid inlet stop valve;

[0047] 3. Discharge equipment, 31. Discharge check valve, 32. Discharge flow monitor, 321. Discharge stop valve, 33. Dosing device, 331. Dispensing tube, 332. Dosing tube, 333. Filling needle;

[0048] 4. stirring equipment, 41. stirring brush, 411. liquid surface scraper, 412. central prism, 42. stirring motor, 43. magnetic screen;

[0049] 5. Sampling equipment, 51. Sampling valve, 511. Dropper, 52. Sampling bottle rack, 520. Sampling bottle, 521. Sampling bottle sensor, 522. Intermediate motor, 53. Marking device;

[0050] 6. Support device, 61. Support frame, 62. Lifting frame. DETAILED DESCRIPTION

[0051] The following will be combined with the attached Figure 1-Figure 7, the technical solutions in the embodiments of the present invention are clearly and completely described. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0052] In the description of the present invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0053] Embodiment 1:

[0054] The embodiment of the present invention discloses a storage device for liquid preparation drug production, referring to Figure 1 , including a storage container 1, a filling device 2 and a liquid discharge device 3. The upper part of the storage container 1 is connected to the filling device 2 through a pipeline, and the lower part of the storage container 1 is connected to the liquid discharge device 3 through a pipeline. A stirring device 4 is installed in the storage container 1, and the stirring device 4 is always in a rotating state in the storage container 1. A supporting device 6 is provided on the outer surface of the storage container 1. A sampling device 5 is installed and connected on the pipeline connecting the filling device 2 and the storage container 1. The sampling device 5 automatically extracts a part of the liquid medicine from the pipeline connecting the filling device 2 and the storage container 1 as a preserved sample at a time interval.

[0055] When in use, the filling equipment 2 is connected to an external production equipment to fill the produced Acanthopanax Senticosus Brain Mixture, Deer Antler and Ginseng Whip Wine, Ginkgo Leaf Drops, etc. or semi-finished products into the storage container 1 for storage. When it needs to be filled into other production devices or medicine bottles, the discharge equipment 3 is started to transport the liquid medicine stored in the storage container 1 out.

[0056] During the storage process of the storage container 1, the stirring device 4 is always in a stirring state.

[0057] The sampling device 5 is activated once a certain amount of liquid medicine is filled into the filling device 2 according to the filling amount of the filling device 2 to take out a part of the liquid medicine in the filling device 2 for retention.

[0058] The supporting device 6 is used to fix the whole device on the ground.

[0059] Embodiment 2:

[0060] On the basis of Example 1, add:

[0061] Reference Figure 3 and Figure 4 The storage container 1 includes a container shell 11, which is a closed metal container. The outside of the container shell 11 is wrapped with an insulation layer 111, and the insulation layer 111 is made of insulation material. A cooling layer 112 is arranged between the insulation layer 111 and the container shell 11, and the cooling layer 112 is externally connected to a heat exchange device.

[0062] The cooling layer 112 is made of a water-absorbing material. Cooling water is poured into the cooling layer 112 from the top. The cooling layer 112 fully absorbs the cooling water. The cooling water flows through the cooling layer 112 from top to bottom, and then flows out at the bottom of the cooling layer 112 and returns to the external heat exchange device to complete the cooling cycle.

[0063] A reflective film is attached to the outer surface of the thermal insulation layer 111 to prevent the internal temperature from rising due to direct sunlight.

[0064] Embodiment 3:

[0065] On the basis of Example 2, add:

[0066] Reference Figure 3 , Figure 4 , Figure 6 and Figure 7 The container shell 11 has a liquid inlet 12 near the top end, and a liquid inlet filter 121 is installed at the liquid inlet 12. The container shell 11 has a liquid discharge port 13 near the bottom end, and a liquid discharge filter 131 is installed at the liquid discharge port 13.

[0067] Reference Figure 3 and Figure 4 The filling device 2 is connected to the liquid inlet 12 through a pipeline, and then connected to the container shell 11. The filling device 2 includes a filling pump 21. The liquid outlet of the filling pump 21 is connected to the liquid inlet 12 through a pipeline. A liquid inlet check valve 22 is installed on the pipeline connecting the filling pump 21 and the liquid inlet 12. The liquid inlet check valve 22 only allows the liquid medicine to enter the container shell 11 in one direction. A liquid inlet flow monitor 23 is also installed on the pipeline connecting the filling pump 21 and the liquid inlet 12. The liquid inlet flow monitor 23 extends into the pipeline and detects the cumulative amount of liquid medicine poured in. A liquid inlet stop valve 231 is also installed on the pipeline connecting the filling pump 21 and the liquid inlet 12. The liquid inlet stop valve 231 is connected in series with the liquid inlet check valve 22. A reflux pipe 222 is connected between the liquid outlet and the liquid inlet of the filling pump 21. A reflux valve 221 is installed on the reflux pipe 222. The reflux valve 221 is a pressure control valve.

[0068] The filling pump 21 actively fills the liquid medicine into the container shell 11, and the liquid inlet check valve 22 allows the liquid medicine to be filled into the container shell 11, but does not allow it to flow out of the container shell 11. The liquid inlet check valve 22 is a pressure valve, which requires a certain delivery pressure to be filled, and has a certain resilience to be immediately cut off when the filling stops.

[0069] The liquid inlet flow monitor 23 records the single filling volume, and resets to zero when the next filling occurs. The operator controls the replenishment according to the missing amount of the container shell 11. When the liquid is replenished, the liquid inlet stop valve 231 is immediately closed to stop the filling.

[0070] When the liquid inlet stop valve 231 is suddenly closed, the filling pump 21 is still filling and cannot be stopped immediately. Therefore, it is necessary to open the reflux valve 221 in advance so that the liquid input by the filling pump 21 flows back through the reflux pipe 222 to relieve pressure, thereby avoiding sudden liquid supply pressure shock to damage the pipeline and the filling pump 21.

[0071] Reference Figure 3 and Figure 4 The discharge device 3 is connected to the discharge port 13 through a pipeline, and then connected to the container shell 11. The discharge device 3 includes a discharge check valve 31, which is installed at the discharge port 13 through a pipeline. The discharge check valve 31 only allows the liquid to be discharged from the container shell 11 in one direction. A discharge flow monitor 32 is installed between the discharge check valve 31 and the discharge port 13. The discharge flow monitor 32 extends into the pipeline and detects the cumulative output of the liquid. A discharge stop valve 321 is installed on one side of the discharge flow monitor 32. The discharge stop valve 321 is connected in series with the discharge check valve 31. A quantitative device 33 is connected to the side of the discharge check valve 31 away from the container shell 11 through a pipeline. The quantitative device 33 includes a dispensing tube 331, a quantitative tube 332 and a filling needle 333. The dispensing tube 331 is connected to multiple quantitative tubes 332 through a pipeline, and a filling needle 333 is connected to the bottom of each quantitative tube 332.

[0072] When it is necessary to drain the liquid, open the drain stop valve 321, and the liquid in the container shell 11 is discharged through the drain stop valve 321 and the drain check valve 31 by gravity or internal air pressure. The function of the drain check valve 31 refers to the liquid inlet check valve 22. The dispensing tube 331 distributes the liquid medicine to multiple quantitative tubes 332. A certain amount of liquid medicine is first stored in the quantitative tubes 332. After all the quantitative tubes 332 are full, the liquid medicine is filled into the bottle through the filling needle 333.

[0073] The drainage flow monitor 32 monitors the drainage volume to avoid draining the container shell 11 and affecting the pharmaceutical processing.

[0074] Embodiment 4:

[0075] On the basis of Example 2, add:

[0076] Reference Figure 3 and Figure 4 The top of the container shell 11 is provided with a filling port 15 and an exhaust port 16. The filling port 15 is connected to an air pump 152. A filling valve 151 is installed on the pipeline connecting the air pump 152 and the filling port 15. The air pump 152 is externally connected to a nitrogen tank, and the exhaust port 16 is connected to an exhaust valve 161.

[0077] When liquid is poured into the container shell 11, the exhaust valve 161 opens, and the gas in the container shell 11 is discharged from the exhaust port 16 along with the liquid.

[0078] When discharging the liquid medicine from the container shell 11, the filling valve 151 is opened, and the air pump 152 is started to input nitrogen into the container shell 11, so that the liquid medicine can be discharged smoothly. At the same time, the air pump 152 applies pressure to quickly discharge the liquid medicine.

[0079] When the container shell 11 is normally stored, the air pump 152 is used to inject high-pressure gas into the container shell 11, which is beneficial to reduce the volatilization of the internal components of the liquid medicine.

[0080] Reference Figure 3-Figure 5 A plurality of observation ports 14 are provided on the side of the container shell 11, and the observation ports 14 are arranged vertically and spaced apart, and are blocked by glass. A light shield 141 is detachably mounted on the observation port 14, and a slag discharge port 17 is provided at the bottom of the container shell 11, and a plurality of sedimentation boxes 171 are slidably mounted directly below the slag discharge port 17, and the sedimentation boxes 171 are cyclically slidably positioned directly below the slag discharge port 17, and a cleaning port 18 is provided on the container shell 11, and the cleaning port 18 is covered and closed by a closing cover 181, and one side of the closing cover 181 is swung and mounted on the container shell 11 by a hinge, and the other side is detachably connected to the container shell 11 by a lock.

[0081] There are multiple observation ports 14 from top to bottom, which can be used to check the liquid level. When checking, the light shielding cover 141 is opened, and the light shielding cover 141 is closed after the observation is completed.

[0082] The sedimentation box 171 slides from one side to the bottom of the slag discharge port 17 and seals the slag discharge port 17, and the sediment settles into the sedimentation box 171. After a period of time, another sedimentation box 171 is used to slide in from one side and come into close contact with the sedimentation box 171 that needs to be replaced, and then the two sedimentation boxes 171 slide to one side, and the slag discharge port 17 is always kept sealed during the process. Until the new sedimentation box 171 is located directly below the slag discharge port 17, the replaced sedimentation box 171 slides out from the other side and is removed.

[0083] The cleaning port 18 is usually closed. When the liquid medicine needs to be replaced, all the liquid medicine inside the container shell 11 is drained, and then the cleaning port 18 is opened to thoroughly clean the inside of the container shell 11 .

[0084] Embodiment 5:

[0085] On the basis of Example 1, add:

[0086] Reference Figure 4 The stirring device 4 includes a stirring brush 41 and a stirring motor 42, wherein the stirring brush 41 is connected to the rotating main shaft of the stirring motor 42, and the stirring brushes 41 are arranged in a circle around the rotating main shaft of the stirring motor 42. The rotating main shaft of the stirring motor 42 is also connected to a central prism 412 of the stirring motor, and a liquid scraper 411 is slidably sleeved on the central prism 412. The liquid scraper 411 floats on the surface of the liquid medicine and slides up and down along the central prism 412 following the height fluctuation of the liquid medicine. The cross-section of the central prism 412 is a polygon and cooperates with the central through-hole cross-section of the liquid scraper 411 to achieve circumferential fixation. A magnetic screen 43 is fixedly arranged at the bottom of the stirring brush 41, and the magnetic screen 43 contains a permanent magnetic material.

[0087] The stirring motor 42 drives the stirring brush 41 to rotate and stir the medicine liquid. The density of the liquid scraper 411 is less than that of the medicine liquid, so it can float on the surface of the medicine liquid and follow the ups and downs of the liquid surface. The liquid scraper 411 slides up and down along the central prism 412 as it follows the ups and downs of the liquid surface. When the stirring motor 42 drives the central prism 412 to rotate, it drives the liquid scraper 411 to rotate, and the liquid scraper 411 stirs the surface of the medicine liquid.

[0088] The magnetic screen 43 can absorb metal substances in the liquid medicine to reduce pollution.

[0089] Reference Figure 2 The sampling device 5 includes a sampling valve 51, one side of the sampling valve 51 is connected to the pipeline of the filling device 2 through a pipeline, and the other side is connected to the dripping tube 511 through a pipeline. A sampling bottle 520 is arranged directly below the dripping tube 511. The sampling bottles 520 are arranged at intervals on a sampling bottle rack 52. The sampling bottle rack 52 is driven by an intermittent motor 522 to control intermittent swing, thereby driving the sampling bottles 520 to be transferred to the bottom of the dripping tube 511 in sequence. A sampling bottle sensor 521 is installed on one side of the dripping tube 511, and a marking device 53 is installed on the other side.

[0090] When a certain amount of liquid medicine flows through the infusion pipeline of the filling equipment 2, the sampling valve 51 automatically opens to lead the liquid medicine from the filling equipment 2 to the drip tube 511, and the drip tube 511 pours a small amount of liquid medicine into the sampling bottle 520. Then the sampling bottle rack 52 rotates to allow the next sampling bottle 520 to be transferred to the bottom of the drip tube 511. The sampling bottle sensor 521 is used to detect the next sampling bottle 520. If there is no sampling bottle 520 or the sampling bottle 520 is full, an alarm is issued and sampling is stopped. The marking device 53 marks the sampling bottle 520 after sampling, marking the sampling time, batch, liquid medicine name and other information. After the sampling bottle 520 is sampled, it is removed and a new sampling bottle 520 is placed. The removed sampling bottle 520 is transported to the testing agency for testing to ensure that the product is qualified. If it is unqualified, it is convenient to recall the same batch of products.

[0091] Reference Figure 3 and Figure 4 The supporting device 6 includes a supporting frame 61 and a hanging frame 62 . The supporting frame 61 is installed at the bottom of the storage container 1 and fixed on the ground, and the hanging frame 62 is installed on the top of the storage container 1 .

[0092] During installation, a crane rope is used to tie the crane to the hoisting frame 62 for hoisting. After positioning, the support frame 61 is supported and fixed with cement.

[0093] The above contents are merely examples and explanations of the structure of the present invention. The technicians in this technical field may make various modifications or additions to the specific embodiments described or replace them in a similar manner. As long as they do not deviate from the scope defined by the structure of the invention, they should all fall within the protection scope of the present invention.

Claims

1. A storage device for the production of liquid preparation drugs, comprising a storage container (1), a filling device (2) and a liquid discharge device (3), wherein the upper portion of the storage container (1) is connected to the filling device (2) via a pipeline, and the lower portion of the storage container (1) is connected to the liquid discharge device (3) via a pipeline, characterized in that: A stirring device (4) is installed in the storage container (1), and a supporting device (6) is provided on the outer surface of the storage container (1); A sampling device (5) is installed and connected to the pipeline connecting the filling device (2) and the storage container (1), and the sampling device (5) automatically extracts a portion of the liquid medicine from the pipeline connecting the filling device (2) and the storage container (1) at a certain interval as a storage sample; The storage container (1) comprises a container shell (11), the container shell (11) is wrapped with a heat-insulating layer (111) on the outside, a cooling layer (112) is provided between the heat-insulating layer (111) and the container shell (11), and the cooling layer (112) is externally connected to a heat exchange device; The container shell (11) is provided with a liquid inlet (12) near the top end, and a liquid inlet filter (121) is installed at the liquid inlet (12); the container shell (11) is provided with a liquid discharge port (13) near the bottom end, and a liquid discharge filter (131) is installed at the liquid discharge port (13); The filling device (2) is connected to the liquid inlet (12) via a pipeline, and is further connected to the container shell (11). The filling device (2) comprises a filling pump (21). The liquid outlet of the filling pump (21) is connected to the liquid inlet (12) via a pipeline. A liquid inlet check valve (22) is installed on the pipeline connecting the filling pump (21) and the liquid inlet (12). A liquid inlet flow monitor (23) is also installed on the pipeline connecting the filling pump (21) and the liquid inlet (12). The flow monitor (23) extends into the pipeline and detects the cumulative amount of liquid medicine poured in. A liquid inlet stop valve (231) is also installed on the pipeline connecting the filling pump (21) and the liquid inlet (12). The liquid inlet stop valve (231) is connected in series with the liquid inlet check valve (22). A reflux pipe (222) is connected between the liquid outlet and the liquid inlet of the filling pump (21). A reflux valve (221) is installed on the reflux pipe (222). The reflux valve (221) is a pressure control valve. The liquid discharge device (3) is connected to the liquid discharge port (13) through a pipeline, and is further connected to the container shell (11). The liquid discharge device (3) comprises a liquid discharge check valve (31). The liquid discharge check valve (31) is installed at the liquid discharge port (13) through a pipeline. A liquid discharge flow monitor (32) is installed between the liquid discharge check valve (31) and the liquid discharge port (13). The liquid discharge flow monitor (32) extends into the pipeline and detects the accumulated liquid discharge. A liquid discharge flow monitor (32) is installed on one side. a liquid discharge stop valve (321), the liquid discharge stop valve (321) being connected in series with the liquid discharge check valve (31); the liquid discharge check valve (31) being connected to a dosing device (33) via a pipeline on a side away from the container shell (11); the dosing device (33) comprising a liquid dispensing tube (331), a dosing tube (332) and a liquid filling needle (333); the liquid dispensing tube (331) being connected to a plurality of dosing tubes (332) via a pipeline; and a liquid filling needle (333) being connected to the bottom of each of the dosing tubes (332); The stirring device (4) comprises a stirring brush (41) and a stirring motor (42), wherein the stirring brush (41) is connected to the rotating main shaft of the stirring motor (42), and the stirring brushes (41) are arranged in a circle around the rotating main shaft of the stirring motor (42). The rotating main shaft of the stirring motor (42) is also connected to a central prism (412) of the stirring motor, and a liquid scraper (411) is slidably sleeved on the central prism (412). The liquid scraper (411) floats on the surface of the liquid medicine and slides up and down along the central prism (412) following the height fluctuation of the liquid medicine. The cross section of the central prism (412) is polygonal and cooperates with the cross section of the central through hole of the liquid scraper (411) to achieve circumferential fixation. A magnetic screen (43) is fixedly arranged at the bottom of the stirring brush (41), and the magnetic screen (43) comprises a permanent magnetic material.

2. A storage device for liquid drug production according to claim 1, characterized in that: The top of the container shell (11) is provided with a gas filling port (15) and an exhaust port (16); the gas filling port (15) is connected to an air pump (152); a gas filling valve (151) is installed on a pipeline connecting the air pump (152) and the gas filling port (15); the air pump (152) is externally connected to a nitrogen tank; and the exhaust port (16) is connected to an exhaust valve (161).

3. A storage device for liquid drug production according to claim 1, characterized in that: The container shell (11) has a plurality of observation ports (14) on its side, the observation ports (14) being arranged vertically and spaced apart, the observation ports (14) being blocked by glass, and a light shield (141) being detachably mounted on the observation port (14). The bottom end of the container shell (11) has a slag discharge port (17), and a plurality of sedimentation boxes (171) are slidably mounted directly below the slag discharge port (17). The sedimentation boxes (171) are cyclically slidably positioned directly below the slag discharge port (17). The container shell (11) has a cleaning port (18), and the cleaning port (18) is covered and sealed by a closing cover (181). One side of the closing cover (181) is swung and mounted on the container shell (11) by a hinge, and the other side of the closing cover (181) is detachably connected to the container shell (11) by a lock.

4. A storage device for liquid drug production according to claim 1, characterized in that: The sampling device (5) comprises a sampling valve (51), one side of the sampling valve (51) is connected to a pipeline of a filling device (2) via a pipeline, and the other side of the sampling valve (51) is connected to a dripping tube (511) via a pipeline. A sampling bottle (520) is arranged directly below the dripping tube (511). The sampling bottles (520) are arranged in an interval arrangement on a sampling bottle rack (52). The sampling bottle rack (52) is driven to swing intermittently by an intermittent motor (522), thereby driving the sampling bottles (520) to be sequentially transferred to the bottom of the dripping tube (511). A sampling bottle sensor (521) is installed on one side of the dripping tube (511), and a marking device (53) is installed on the other side.

5. A storage device for liquid drug production according to claim 1, characterized in that: The support device (6) comprises a support frame (61) and a hanging frame (62); the support frame (61) is installed at the bottom of the storage container (1) and fixed on the ground; and the hanging frame (62) is installed at the top of the storage container (1).

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