A traditional Chinese medicine composition, its preparation method and application

Abstract

This invention provides a traditional Chinese medicine composition, its preparation method, and its application, belonging to the technical field of traditional Chinese medicine compositions. The invention comprises the following raw materials in parts by weight: Magnolia officinalis 7-9 parts, Citrus aurantium 4-6 parts, Crataegus pinnatifida (fried) 10-14 parts, Hordeum vulgare germinatum 12-16 parts, Massa fermentata 4-6 parts, Citrus reticulata peel 4-6 parts, Atractylodes lancea 4-5 parts, Areca catechu 2-4 parts, Paeonia lactiflora 6-10 parts, Coptis chinensis 18-22 parts, Pogostemon cablin 3-5 parts, L-malic acid 8-12 parts, and Nicotinamide 0.4-0.6 parts. The raw materials of this invention interact to regulate the acid-producing bacteria in the rumen, promote saliva secretion and rumination, neutralize gastric acid, protect the gastrointestinal mucosa, and prevent and / or treat rumen acidosis in sheep. Preparations containing the composition of this invention are antibiotic-free, pollution-free, safe, and effective; they can be directly added to the diet, have good palatability, and long-term use improves rumen and animal health; the preparation method is simple and inexpensive, resulting in significant economic and social benefits.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine composition technology, and particularly relates to a traditional Chinese medicine composition, its preparation method and application. Background Technology

[0002] Rumen acidosis in sheep is mainly caused by excessive consumption of easily fermentable carbohydrate feed or silage with excessively high acidity, leading to the accumulation of lactic acid in the rumen, rumen microbial imbalance, and ultimately, systemic metabolic disorders. Due to its rapid onset, short course, severe systemic symptoms, and high mortality rate, rumen acidosis is a challenging disease to diagnose and treat clinically.

[0003] Currently, the prevention and treatment of rumen acidosis mainly involve adding sodium bicarbonate and magnesium oxide, or administering antibiotics to inhibit pathogenic bacteria. However, adding sodium bicarbonate and magnesium oxide affects the feed intake rate of sheep, while antibiotics are being gradually phased out. In recent years, the use of traditional Chinese medicine as an adjunct treatment for rumen acidosis has attracted widespread attention. However, the current focus is mainly on treating rumen acidosis using a combination of traditional Chinese and Western medicine. When using traditional Chinese medicine alone to treat rumen acidosis, complex preparation processes are often required, or the treatment effect varies significantly due to differences in the raw materials of the traditional Chinese medicine in the formula. Patent CN116211961A discloses a composition for preventing and treating rumen acidosis in ruminants, the composition comprising the following components: jujube powder, soapberry, arborvitae leaves, Bletilla striata, Magnolia officinalis, radish seed, six-leaf arborvitae, Citrus aurantium, dried tangerine peel, clove, patchouli, white peony root, Atractylodes macrocephala, licorice, active dry yeast, yeast extract, and yeast cell wall. The composition provided by this patent is suitable for the prevention and treatment of rumen acidosis in cattle and sheep. It contains multiple components and requires molasses spray coating to prepare a formulation that can be taken by cattle and sheep. The preparation method is complex and has high requirements for equipment and environment. Li Guangjin (2004) used intravenous injection of glucose saline, vitamins, sodium benzoate, 5% sodium bicarbonate injection, and neostigmine, and intramuscular injection of vitamin B1, supplemented with a decoction of 50g Magnolia officinalis, 50g Citrus aurantium, 120g roasted hawthorn, 200g germinated barley, 50g Shenqu, 45g Citrus reticulata peel, 45g Atractylodes macrocephala, 45g Areca catechu, 80g rhubarb, and 200g Glauber's salt, one dose per day, to treat rumen acidosis in cattle. His method of using a combination of Western medicine and traditional Chinese medicine to treat rumen acidosis in cattle did not prove whether traditional Chinese medicine alone could treat rumen acidosis in cattle.

[0004] Therefore, providing a traditional Chinese medicine composition with good therapeutic effect on rumen acidosis is beneficial to promoting the development of the aquaculture industry. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a traditional Chinese medicine composition that can regulate the acid-producing bacteria in the rumen, neutralize gastric acid, and prevent and / or treat rumen acidosis in sheep.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0007] A traditional Chinese medicine composition comprising the following raw materials in parts by weight: 7-9 parts Magnolia officinalis, 4-6 parts Citrus aurantium, 10-14 parts stir-fried Crataegus pinnatifida, 12-16 parts germinated barley, 4-6 parts medicated leaven, 4-6 parts Citrus reticulata peel, 4-5 parts Atractylodes lancea, 2-4 parts Areca catechu, 6-10 parts Paeonia lactiflora, 18-22 parts Coptis chinensis, 3-5 parts Pogostemon cablin, 8-12 parts L-malic acid, and 0.4-0.6 parts nicotinamide.

[0008] Preferably, the raw materials include the following parts by weight: 7.5-8.5 parts Magnolia officinalis, 4.5-5.5 parts Citrus aurantium, 11-13 parts stir-fried hawthorn, 14-15 parts germinated barley, 4.5-5.5 parts medicated leaven, 4.5-5.5 parts dried tangerine peel, 4.2-4.6 parts Atractylodes lancea, 2.5-3.5 parts Areca catechu, 7-8 parts Paeonia lactiflora, 19-21 parts Coptis chinensis, 3.5-4.5 parts Pogostemon cablin, 9-10 parts L-malic acid, and 0.45-0.55 parts nicotinamide.

[0009] Preferred ingredients include the following parts by weight: 8 parts Magnolia officinalis, 5 parts Citrus aurantium, 12 parts stir-fried hawthorn, 15 parts germinated barley, 5 parts Shenqu (medicated leaven), 5 parts dried tangerine peel, 4.5 parts Atractylodes lancea, 3 parts Areca catechu, 8 parts Paeonia lactiflora, 20 parts Coptis chinensis, 4 parts Pogostemon cablin, 10 parts L-malic acid, and 0.5 parts nicotinamide.

[0010] Another object of the present invention is to provide a method for preparing the traditional Chinese medicine composition, comprising the following steps: drying and pulverizing Magnolia officinalis, Citrus aurantium, stir-fried hawthorn, germinated barley, medicated leaven, Citrus reticulata peel, Atractylodes lancea, Areca catechu, Paeonia lactiflora, Coptis chinensis and Pogostemon cablin respectively; weighing the above-mentioned raw material powders, L-malic acid and nicotinamide in the prescribed amounts; and mixing them into a powder.

[0011] Preferably, the drying temperature is 50℃-60℃.

[0012] Preferably, the moisture content of each raw material after drying is ≤8%.

[0013] Preferably, the particle size of the pulverized material is 80-120 mesh.

[0014] Another object of the present invention is to provide the use of the said traditional Chinese medicine composition in the preparation of a drug for the prevention and / or treatment of rumen acidosis in ruminants.

[0015] Preferably, the traditional Chinese medicine composition regulates the balance of gastrointestinal flora and neutralizes gastric acid.

[0016] Another object of the present invention is to provide a formulation comprising the traditional Chinese medicine composition.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] This invention provides a traditional Chinese medicine composition in which the raw materials interact to regulate the acid-producing bacteria in the rumen, promote saliva secretion and rumination, neutralize gastric acid, protect the gastrointestinal mucosa, balance the rumen, improve immunity, and prevent rumen acidosis. Furthermore, the oral preparation made from this composition is antibiotic-free, pollution-free, safe, and effective. It can be directly added to the diet, has good palatability, and long-term use can improve rumen and animal health. Moreover, the preparation method is simple and inexpensive, resulting in significant economic and social benefits. Attached Figure Description

[0019] Figure 1 : Normal sheep feces;

[0020] Figure 2 : Sheep manure from the model group;

[0021] Figure 3 : The 4 sheep in experimental group 1;

[0022] Figure 4 The four sheep in experimental group 2;

[0023] Figure 5 The four sheep in experimental group 3;

[0024] Figure 6 The four sheep in experimental group 4;

[0025] Figure 7 Sheep feces in experimental group 1;

[0026] Figure 8 Sheep feces in experimental group 2;

[0027] Figure 9 Sheep feces in experimental group 3;

[0028] Figure 10 Sheep feces in experimental group 4. Detailed Implementation

[0029] This invention provides a traditional Chinese medicine composition comprising the following raw materials in parts by weight: 7-9 parts Magnolia officinalis, 4-6 parts Citrus aurantium, 10-14 parts stir-fried Crataegus pinnatifida, 12-16 parts germinated barley, 4-6 parts medicated leaven, 4-6 parts Citrus reticulata peel, 4-5 parts Atractylodes lancea, 2-4 parts Areca catechu, 6-10 parts Paeonia lactiflora, 18-22 parts Coptis chinensis, 3-5 parts Pogostemon cablin, 8-12 parts L-malic acid, and 0.4-0.6 parts nicotinamide. Preferably, the raw materials include the following parts by weight: 7.5-8.5 parts Magnolia officinalis, 4.5-5.5 parts Citrus aurantium, 11-13 parts roasted hawthorn, 14-15 parts germinated barley, 4.5-5.5 parts medicated leaven, 4.5-5.5 parts dried tangerine peel, 4.2-4.6 parts Atractylodes lancea, 2.5-3.5 parts Areca catechu, 7-8 parts Paeonia lactiflora, 19-21 parts Coptis chinensis, 3.5-4.5 parts Pogostemon cablin, 9-10 parts L-malic acid, and 0.45-0.55 parts nicotinamide. More preferably, the raw materials include the following parts by weight: 8 parts Magnolia officinalis, 5 parts Citrus aurantium, 12 parts roasted hawthorn, 15 parts germinated barley, 5 parts medicated leaven, 5 parts dried tangerine peel, 4.5 parts Atractylodes lancea, 3 parts Areca catechu, 8 parts Paeonia lactiflora, 20 parts Coptis chinensis, 4 parts Pogostemon cablin, 10 parts L-malic acid, and 0.5 parts nicotinamide. All raw materials used in this invention are commercially available products well-known to those skilled in the art. L-malic acid is food-grade, and the effective content of nicotinamide is greater than 99%.

[0030] In this invention, Magnolia officinalis refers to the bark, root bark, or branch bark of the Magnolia officinalis plant (Magnolia officinalis var. chinensis). It is warm in nature and pungent in taste. It enters the spleen, stomach, and large intestine meridians. It has the effects of resolving dampness and promoting qi circulation, relieving asthma, resolving food stagnation and phlegm, and dispelling wind and relieving pain. It is mainly used to treat food stagnation and qi stagnation, abdominal distension and constipation, dampness obstructing the middle jiao, epigastric fullness and vomiting, diarrhea, chest fullness and cough, etc. It mainly contains volatile oils, magnolol, and other active ingredients, which have strong antibacterial effects against various pathogens such as Staphylococcus, Streptococcus, and Pasteurella. Magnolia officinalis is pungent and warm in nature, suitable for symptoms such as dampness obstruction, qi stagnation and phlegm, and food stagnation. Its pungent taste can promote qi circulation and resolve dampness, and its warming properties can dispel cold; therefore, it is often used to treat digestive system problems such as intestinal stagnation, abdominal distension and pain, and loss of appetite.

[0031] Citrus aurantium is the dried, mature fruit of the Citrus aurantium plant, belonging to the Rutaceae family. It is warm in nature and bitter in taste. It enters the stomach and large intestine meridians. It has the effects of breaking up stagnation and eliminating food accumulation, soothing the liver and relieving depression, and is mainly used to treat abdominal distension, indigestion, hard lumps, and constipation due to qi stagnation. It mainly contains volatile oils, bitter substances, and other active ingredients, which have a good therapeutic effect on stagnation in the digestive system.

[0032] Fried hawthorn is made by roasting the dried, ripe fruit of the hawthorn plant (Crataegus pinnatifida). It is warm in nature and has a sweet and sour taste. It enters the spleen, stomach, and liver meridians. It has the effects of promoting digestion, removing food stagnation, invigorating blood circulation, and relieving pain. It is mainly used to treat food stagnation, abdominal pain, and hyperlipidemia. It is rich in hawthorn acid, flavonoids, and vitamin C, which can promote digestion and lower blood lipids.

[0033] Fructus Hordei Germinatus is the tender bud of grains such as rice and wheat. It is of neutral nature and sweet in taste. It acts on the Spleen Meridian and Stomach Meridian. It has the effects of strengthening the spleen and promoting digestion, and is mainly used to treat indigestion, dyspepsia, and infantile malnutrition. It contains various enzymes and vitamins.

[0034] Medicated Leaven is a traditional Chinese medicine made from wheat through mold fermentation. It is of warm nature and sweet in taste. It acts on the Spleen Meridian and Stomach Meridian. It helps in promoting digestion, resolving dampness, and strengthening the spleen, and is mainly used to treat indigestion, abdominal distension, and dampness obstructing the middle jiao. It is rich in enzymes and trace elements.

[0035] Pericarpium Citri Reticulatae is the dried ripe pericarp of the citrus plant and its related species in the Rutaceae family. It is of warm nature, bitter and pungent in taste. It acts on the Spleen Meridian, Lung Meridian, and Stomach Meridian. It has the effects of regulating qi, soothing the liver, resolving phlegm, and relieving cough, and is mainly used to treat chest and abdominal distension, cough with excessive phlegm, loss of appetite, etc. It contains volatile oils, hesperidin and other components.

[0036] Rhizoma Atractylodis is the dried rhizome of the Atractylodes lancea plant in the Asteraceae family. It is of warm nature, pungent and bitter in taste. It acts on the Spleen Meridian and Stomach Meridian. It has the effects of strengthening the spleen and promoting digestion, removing dampness and resolving phlegm, and is mainly used to treat weakness of the spleen and stomach, indigestion, and damp turbidity blocking the interior. Rhizoma Atractylodis contains volatile oils, atractylodin and other active ingredients, which can promote digestion and remove dampness pathogens.

[0037] Semen Arecae is the dried ripe seed of the Areca catechu plant in the Palmae family. It is of hot nature, bitter and pungent in taste. It acts on the Spleen Meridian, Stomach Meridian, and Large Intestine Meridian. It has the effects of killing parasites, promoting digestion and resolving stagnation, and diuretic and lithotriptic, and is mainly used to treat ascariasis, indigestion, dysuria, kidney stones, etc. It contains arecoline and other alkaloids, which have a certain effect on the digestive system and urinary system.

[0038] Radix Paeoniae Alba is the root of the Paeonia lactiflora plant in the Paeoniaceae family. It is of cold nature, bitter and sweet in taste. It acts on the Liver Meridian and Spleen Meridian. It has the effect of nourishing blood and promoting blood circulation, and is mainly used to treat blood deficiency and blood stasis, abdominal pain and other diseases. Radix Paeoniae Alba contains paeonolic acid, glycosides and other components, which can nourish yin and blood, and soothe muscles and activate blood circulation.

[0039] Rhizoma Coptidis is the dried rhizome of the Coptis chinensis plant in the Sarumahenryi Oliv. family. It is of cold nature and bitter in taste. It acts on the Gallbladder Meridian, Stomach Meridian, and Heart Meridian. It has the effects of clearing heat and drying dampness, purging fire and detoxifying, and is mainly used to treat damp-heat jaundice, mouth ulcers, dysentery and diarrhea, etc. Rhizoma Coptidis contains berberine, coptisine and other components, and has strong antibacterial and anti-inflammatory effects, and is a commonly used drug for treating heat diseases and heat toxins.

[0040] Herba Pogostemonis is the whole herb of the Pogostemon cablin plant in the Labiatae family. It is of warm nature, pungent and bitter in taste. It acts on the Spleen Meridian and Lung Meridian. It has the effects of promoting qi movement and resolving dampness, and dispersing the lung and relieving cough, and is mainly used to treat damp-heat phlegm stagnation, lung heat cough, chest distress and asthma, etc. Herba Pogostemonis contains pogostone, volatile oils and other components, which can soothe muscles and activate collaterals, relieve exterior syndrome and dispel cold, and is commonly used in the treatment of cold cough, damp-heat phlegm retention and other diseases.

[0041] L-malic acid is an organic acid widely found in various fruits and vegetables, especially abundant in apples. L-malic acid is primarily valued for its effects in promoting saliva secretion, increasing digestive enzyme activity, and relieving fatigue. Its role in metabolic regulation can also help enhance bodily functions.

[0042] Nicotinamide is a form of the water-soluble B vitamin vitamin B3. When used in ruminant feed, nicotinamide can regulate lipid metabolism, reduce blood fatty acid levels, and also alleviate stress and reduce inflammation.

[0043] The present invention provides a method for preparing the traditional Chinese medicine composition, comprising the following steps: drying and pulverizing Magnolia officinalis, Citrus aurantium, stir-fried hawthorn, germinated barley, medicated leaven, Citrus reticulata peel, Atractylodes lancea, Areca catechu, Paeonia lactiflora, Coptis chinensis and Pogostemon cablin respectively; weighing the above raw material powders, L-malic acid and nicotinamide in the prescribed amounts; and mixing them into a powder.

[0044] In this invention, the drying temperature is 50℃-60℃, and preferably, the moisture content of each raw material after drying is ≤8%. The drying process of the medicinal materials in this invention removes moisture, preventing mold, insect infestation, and decomposition and destruction of active ingredients, thus ensuring the quality of the medicinal materials and facilitating storage and transportation.

[0045] In this invention, the raw materials of traditional Chinese medicine are dried and then pulverized. The particle size of the pulverized material is 80-120 mesh, preferably 100-110 mesh. The pulverized raw materials of traditional Chinese medicine can be thoroughly mixed with L-malic acid and nicotinamide, giving full play to the interaction between the components. The mixed powder can be mixed with feed for sheep to eat freely, regulating the acid-producing bacteria in their rumen, promoting saliva secretion and rumination, neutralizing gastric acid, protecting the gastrointestinal mucosa, balancing the rumen environment, improving immunity, and preventing rumen acidosis in sheep.

[0046] This invention also provides the use of the aforementioned traditional Chinese medicine composition in the preparation of drugs for the prevention and / or treatment of rumen acidosis in ruminants. Preferably, the traditional Chinese medicine composition regulates the balance of gastrointestinal flora and neutralizes gastric acid. The traditional Chinese medicine composition of this invention is preferably used in the preparation of drugs for the prevention and / or treatment of rumen acidosis in sheep.

[0047] This invention also provides a formulation comprising the aforementioned traditional Chinese medicine composition. The formulation containing the composition of this invention is antibiotic-free, pollution-free, safe and effective, can be directly added to the diet, has good palatability, and long-term use improves rumen and animal health.

[0048] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0049] Example 1

[0050] The traditional Chinese medicine composition includes the following raw materials in parts by weight: 8 parts Magnolia officinalis, 5 parts Citrus aurantium, 12 parts stir-fried hawthorn, 15 parts germinated barley, 5 parts medicated leaven, 5 parts dried tangerine peel, 4.5 parts Atractylodes lancea, 3 parts Areca catechu, 8 parts Paeonia lactiflora, 20 parts Coptis chinensis, 4 parts Pogostemon cablin, 10 parts L-malic acid, and 0.5 parts nicotinamide.

[0051] Preparation method: Magnolia officinalis, Citrus aurantium, stir-fried hawthorn, germinated barley, medicated leaven, dried tangerine peel, Atractylodes lancea, Areca catechu, Paeonia lactiflora, Coptis chinensis, and Pogostemon cablin were dried at 55℃ until the moisture content was ≤8%. Then, each herb was pulverized and passed through a 100-mesh sieve. The powdered herb raw materials, L-malic acid, and nicotinamide were weighed according to the formula ratio and mixed into a powder.

[0052] Example 2

[0053] The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine composition includes the following raw materials in parts by weight: 7 parts Magnolia officinalis, 4 parts Citrus aurantium, 11 parts stir-fried hawthorn, 12 parts germinated barley, 4 parts medicated leaven, 4 parts dried tangerine peel, 4 parts Atractylodes lancea, 2 parts areca nut, 6 parts white peony root, 18 parts Coptis chinensis, 3 parts agastache rugosa, 9 parts L-malic acid, and 0.45 parts nicotinamide.

[0054] Example 3

[0055] The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine composition includes the following raw materials in parts by weight: 9 parts Magnolia officinalis, 6 parts Citrus aurantium, 14 parts stir-fried hawthorn, 16 parts germinated barley, 6 parts medicated leaven, 6 parts dried tangerine peel, 5 parts Atractylodes lancea, 4 parts Areca catechu, 10 parts Paeonia lactiflora, 22 parts Coptis chinensis, 4.5 parts Pogostemon cablin, 12 parts L-malic acid, and 0.5 parts nicotinamide.

[0056] Comparative Example 1

[0057] The difference between this comparative example and Example 1 is that the traditional Chinese medicine composition includes the following raw materials in parts by weight: 5 parts Magnolia officinalis, 5 parts Citrus aurantium, 12 parts stir-fried hawthorn, 20 parts germinated barley, 5 parts Shenqu (medicated leaven), 4.5 parts Citrus reticulata peel, 4.5 parts Atractylodes macrocephala, 4.5 parts Areca catechu, 8 parts rhubarb, and 20 parts Glauber's salt.

[0058] Example 4

[0059] Comparison of the effects of different Chinese herbal medicine combinations

[0060] 1. To establish an experimental animal model of rumen acidosis in sheep, eight ewes weighing 35kg ± 5kg were selected and divided into a normal group and a model group, with four ewes in each group. The normal group received the same diet as before, consisting of alfalfa hay. The model group was fed a diet with a concentrate-to-roughage ratio of 70:30, consisting of cornmeal and alfalfa hay. The total daily feed for each group was 1.5kg, fed at 7:00 AM and 7:00 PM, with free access to water. Clinical symptoms were observed.

[0061] Approximately 21 hours after the first feeding, the control group showed no abnormalities, and their feces were smooth and granular. Figure 1The model group showed watery, loose stools. Figure 2 Clinical symptoms included reduced rumination, foul-smelling breath, and decreased urination. This confirmed the successful establishment of the model.

[0062] 2. A sheep rumen acidosis experimental model was constructed using the method described in step 1. The experimental models were randomly divided into 4 groups, with 4 sheep in each group. Each group was fed a diet with a concentrate-to-roughage ratio of 70:30, consisting of cornmeal and alfalfa hay. Experimental group 1 ( Figure 3 The powder prepared in Example 1 was added to the experimental group 2 at a rate of 6% of the diet mass. Figure 4 The powder prepared in Example 2 was added to the experimental group 3 at a rate of 6% of the diet mass. Figure 5 The powder prepared in Comparative Example 1 was added at a rate of 6% of the diet mass. Experimental Group 4 ( Figure 6 The control group received no added powder. Each group received a total daily ration of 1.5 kg, fed at 7:00 AM and 7:00 PM, with free access to feed and water. In this invention, each experimental sheep used a neck clamp to ensure that each sheep consumed its own feed trough, maintaining a consistent feed intake. The effectiveness of the rumen acidosis prevention experiment was observed by examining fecal morphology and clinical symptoms.

[0063] The results are as follows Figure 7-10 As shown, 24 hours after the first feeding, all four sheep in experimental group 4 developed diarrhea symptoms, presenting with watery loose stools. Figure 10 Furthermore, their exhaled breath had a sour, foul odor, rumination was reduced, and urination was decreased. In experimental group 1, the feces of the four sheep were generally normal in shape. Figure 7 No clinical symptoms were observed. The feces of the four sheep in experimental group 2 were basically normal in appearance. Figure 8 ( ), without clinical symptoms.

[0064] The traditional Chinese medicine composition in Comparative Example 1 was the same as that used by Li Guangjin et al. (Li Guangjin, Wang Lan, Zou Benlian. Integrated Traditional Chinese and Western Medicine Treatment of Bovine Rumen Acidosis [J]. Journal of Traditional Chinese Veterinary Medicine, 2004(01):14.) when treating bovine rumen acidosis with integrated traditional Chinese and Western medicine. In Experimental Group 3, 4 sheep consumed the traditional Chinese medicine composition provided in Comparative Example 1. Although no obvious diarrhea symptoms were observed, the feces were in clumps. Figure 9This invention has found that, compared to Comparative Example 1, the herbal composition of this invention, by replacing Atractylodes macrocephala with Atractylodes lancea, exhibits stronger warming and qi-regulating, dampness-resolving and diarrhea-stopping properties. Atractylodes lancea has a strong blood-activating and stasis-removing effect, which helps improve blood circulation, promotes meridian unblocking, and relieves gastrointestinal pain and inflammation. Atractylodes lancea contains more volatile oil components, possessing certain antibacterial and anti-inflammatory effects, which may provide better relief for some gastrointestinal inflammations and help prevent the occurrence of gastrointestinal diseases such as rumen acidosis in sheep. Replacing rhubarb with Paeonia lactiflora, while having a laxative effect, can easily cause adverse reactions such as diarrhea, while Paeonia lactiflora is a milder herb with blood-activating, stasis-removing, calming, and pain-relieving effects, making it more suitable for regulating gastrointestinal function and relieving pain. Replacing Glauber's salt with Coptis chinensis, which has heat-clearing, dampness-drying, fire-purging, and detoxifying effects, more effectively reduces inflammation and kills bacteria, helping to treat rumen acidosis in sheep. This invention also adds patchouli, which has the effects of dispelling wind and dampness, reducing inflammation and fighting bacteria, helping to improve indigestion and prevent gastric acidosis. The newly added L-malic acid and nicotinamide are vitamin-like components that help regulate gastric acid secretion and promote digestion, further contributing to improving indigestion and preventing rumen acidosis. Therefore, this invention is more comprehensive and effective in regulating gastrointestinal function, reducing inflammation and killing bacteria, relieving pain, and preventing rumen acidosis.

[0065] The traditional Chinese medicine composition provided by this invention contains no Western medicine ingredients, but instead includes food-grade L-malic acid and nicotinamide, making it more in line with the requirements of green and healthy animal husbandry. This invention has achieved good results in the prevention and treatment of rumen acidosis in sheep. The method of use is also simpler, eliminating the need for decoction preparation, making it more convenient and efficient. The traditional Chinese medicine composition provided by this invention has good preventive and therapeutic effects on rumen acidosis in sheep.

[0066] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for the prevention and / or treatment of rumen acidosis in ruminants, characterized in that, It is composed of the following raw materials in parts by weight: 7-9 parts Magnolia officinalis, 4-6 parts Citrus aurantium, 10-14 parts stir-fried hawthorn, 12-16 parts germinated barley, 4-6 parts medicated leaven, 4-6 parts dried tangerine peel, 4-5 parts Atractylodes lancea, 2-4 parts areca nut, 6-10 parts white peony root, 18-22 parts Coptis chinensis, 3-5 parts agastache rugosa, 8-12 parts L-malic acid, and 0.4-0.6 parts nicotinamide.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, It is composed of the following raw materials in parts by weight: Magnolia officinalis 7.5-8.5 parts, Citrus aurantium 4.5-5.5 parts, stir-fried hawthorn 11-13 parts, germinated barley 14-15 parts, medicated leaven 4.5-5.5 parts, dried tangerine peel 4.5-5.5 parts, Atractylodes lancea 4.2-4.6 parts, Areca catechu 2.5-3.5 parts, Paeonia lactiflora 7-8 parts, Coptis chinensis 19-21 parts, Pogostemon cablin 3.5-4.5 parts, L-malic acid 9-10 parts, and nicotinamide 0.45-0.55 parts.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, It is composed of the following ingredients in parts by weight: 8 parts Magnolia officinalis, 5 parts Citrus aurantium, 12 parts stir-fried hawthorn, 15 parts germinated barley, 5 parts medicated leaven, 5 parts dried tangerine peel, 4.5 parts Atractylodes lancea, 3 parts Areca catechu, 8 parts Paeonia lactiflora, 20 parts Coptis chinensis, 4 parts Pogostemon cablin, 10 parts L-malic acid, and 0.5 parts nicotinamide.

4. A method for preparing the traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The process includes the following steps: drying and pulverizing Magnolia officinalis, Citrus aurantium, stir-fried hawthorn, germinated barley, medicated leaven, dried tangerine peel, Atractylodes lancea, Areca catechu, Paeonia lactiflora, Coptis chinensis, and Pogostemon cablin, weighing the above raw material powders, L-malic acid, and nicotinamide in the prescribed amounts, and mixing them into a powder.

5. The preparation method according to claim 4, characterized in that, The drying temperature is 50℃-60℃.

6. The preparation method according to claim 5, characterized in that, The moisture content of each raw material after drying is ≤8%.

7. The preparation method according to claim 4, characterized in that, The particle size of the pulverized material is 80-120 mesh.

8. The use of the traditional Chinese medicine composition according to any one of claims 1-3 in the preparation of a drug for the prevention and / or treatment of rumen acidosis in ruminants.

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