Anti-allergic cleaning toothpaste and preparation method thereof

Abstract

The invention provides an anti-sensitivity cleaning toothpaste and a preparation method thereof, wherein the toothpaste comprises the following raw materials in parts by weight: 20-25 parts of hydroxyapatite, 2-6 parts of sodium guaiacyl sulfonate, 2-5 parts of a first plant extract, 1-3 parts of a second plant extract, 5-10 parts of borneol, 4-9 parts of strontium chloride hexahydrate, 10-15 parts of silicon dioxide, 1-3 parts of a thickener, 2-5 parts of a moisturizer, 1-3 parts of a foaming agent and 30-35 parts of deionized water. The toothpaste of the invention has good anti-sensitivity and anti-inflammatory effects and high storage stability, and is an anti-sensitivity toothpaste specifically used for people who use bleaching agents to bleach their teeth.

Description

Technical Field

[0001] The invention belongs to the technical field of toothpaste, and particularly relates to an anti-allergic cleaning toothpaste and a preparation method thereof. Background Art

[0002] Tooth sensitivity is usually caused by the wear of tooth enamel or gum recession, which exposes the dentin inside the teeth. The tiny tubes in the dentin are stimulated by cold, heat, sweet, sour food or drink, and air, causing pain. Anti-sensitivity toothpaste is a toothpaste designed specifically for tooth sensitivity problems. The main ingredients usually contain substances that can help reduce or prevent the symptoms of tooth sensitivity.

[0003] In the prior art, toothpastes achieve anti-sensitivity effects mainly through the following methods: (1) Many anti-sensitivity toothpastes contain ingredients such as potassium nitrate, strontium chloride, and strontium acetate. These ingredients can form a protective layer on the surface of the teeth, or block the openings of the dentinal tubules through chemical reactions, thereby reducing the direct stimulation of external stimuli (such as cold, heat, sweetness, and acidity) on the pulp and reducing sensitivity. (2) Some anti-sensitivity toothpastes contain ingredients such as fluoride and hydroxyapatite, which can help strengthen tooth enamel, promote remineralization, form a barrier, and reduce the exposure of dentin, thereby achieving the effect of reducing sensitivity. (3) Specific anti-sensitivity ingredients such as potassium salts can act on the nerve endings of the teeth, reduce their reactivity to stimuli, reduce the transmission of pain signals, and thus relieve sensitive symptoms. (4) Some anti-sensitivity toothpastes may also contain ingredients with mild anti-inflammatory or analgesic effects, such as fluoride, which can help relieve sensitivity problems caused by periodontal disease or mild gingival inflammation. (5) On the basis of ordinary toothpaste, certain Chinese herbal medicine extracts are added, which have the effects of clearing away heat and detoxifying, anti-inflammatory and hemostatic, and have a certain auxiliary effect in relieving gingival inflammation.

[0004] At present, adding Chinese herbal extracts to ordinary toothpaste to improve the anti-allergic effect of toothpaste will face the following technical problems: (1) Stability issues: Chinese herbal extracts usually contain a variety of active ingredients, which may be sensitive to temperature, light, air or other chemical components in toothpaste, resulting in easy decomposition and failure during storage, affecting the stability and shelf life of the toothpaste. (2) Compatibility: Chinese herbal extracts need to be compatible with other ingredients in toothpaste (such as abrasives, moisturizers, preservatives, etc.), otherwise it may cause precipitation, discoloration, separation, etc., affecting product quality and appearance. (3) Consumer acceptance: The taste and mouthfeel of Chinese herbal toothpaste may be different from traditional toothpaste, and consumers may need time to adapt, which affects market acceptance and product promotion.

[0005] In pursuit of whitening teeth, more and more people choose to use bleaching agents to whiten their teeth. However, tooth sensitivity is a common side effect after using bleaching agents to whiten teeth. Although the anti-sensitivity toothpaste on the market is developing rapidly and there are many types. However, there is no anti-sensitivity toothpaste specifically for people who use bleaching agents to whiten their teeth, and the anti-sensitivity toothpaste products on the market are not ideal.

[0006] Therefore, there is an urgent need for an anti-allergic cleaning toothpaste and a preparation method thereof. Summary of the invention

[0007] The purpose of the present invention is to provide an anti-allergic cleaning toothpaste and a preparation method thereof.

[0008] In order to achieve the above object, the present invention provides the following technical solutions:

[0009] An anti-sensitivity cleaning toothpaste comprises the following raw materials in parts by mass: 20-25 parts of hydroxyapatite, 2-6 parts of sodium guaiacyl sulfonate, 2-5 parts of a first plant extract, 1-3 parts of a second plant extract, 5-10 parts of borneol, 4-9 parts of strontium chloride hexahydrate, 10-15 parts of silicon dioxide, 1-3 parts of a thickener, 2-5 parts of a humectant, 1-3 parts of a foaming agent and 30-35 parts of deionized water.

[0010] Furthermore, the preparation method of the first plant extract is:

[0011] (1) mixing agrimony, wild chrysanthemum, forsythia, and honeysuckle, and grinding the mixture to an average particle size of 60-80 meshes to obtain a Chinese medicine powder;

[0012] (2) mixing the Chinese medicine powder, water and Lactobacillus furfurali in a mass ratio of 1:8-10:0.1-0.2, performing anaerobic fermentation at a fermentation temperature of 30-35° C. and a fermentation time of 15-17 h, and sterilizing to obtain a first fermentation product;

[0013] (3) adding 0.2-0.3 times the mass of the Chinese medicine powder to the first fermentation product, performing anaerobic fermentation at a temperature of 30-35° C. for 12-14 h, and sterilizing to obtain a second fermentation product;

[0014] (4) filtering the second fermentation product to obtain a filtrate, and concentrating and drying the filtrate to obtain a first plant extract.

[0015] Furthermore, the mass ratio of agrimony, wild chrysanthemum, forsythia and honeysuckle is 1:1.2-1.4:0.5-0.8:1.6-1.9.

[0016] People who use bleaching agents to bleach their teeth often have tooth sensitivity after bleaching, which is the most common side effect of bleaching agents. The bleaching agents penetrate the tooth enamel and enter the dentinal tubules, which may stimulate the pulp tissue and cause pain or inflammation. Currently, there is no toothpaste on the market that is specifically designed for this group of people, resulting in some anti-sensitivity toothpastes that are not suitable for people who use bleaching agents to bleach their teeth, and even make people who are sensitive after tooth bleaching more sensitive to certain ingredients contained in these toothpastes. The present invention can improve the anti-sensitivity of toothpaste by adding the first plant extract to the toothpaste, and has a good anti-sensitivity effect on people who use bleaching agents to bleach their teeth. Agrimony, wild chrysanthemum, forsythia, and honeysuckle are fermented by two kinds of bacteria, and the active components in the product may help alleviate gingivitis, reduce the discomfort when teeth are sensitive, and can help improve the oral health environment.

[0017] Furthermore, the preparation method of the second plant extract is:

[0018] (1) Mix Piper longum, Cortex Moutan and Angelica dahurica, and grind to an average particle size of 60-80 mesh to obtain a mixed powder.

[0019] (2) adding 6-8 times the mass of water to the mixed powder, heating and extracting at 60-70° C. for 2-3 hours to obtain a water-extracted product;

[0020] (3) adding a complex enzyme to the water extraction product, immersing the product at 40-45° C. for 12-15 hours for enzymolysis, and heating the product at 120-122° C. for 15-20 minutes to inactivate the enzyme to obtain an enzymolysis solution;

[0021] (4) filtering the enzymatic hydrolyzate to obtain a filtrate, and concentrating and drying the filtrate to obtain a second plant extract.

[0022] Furthermore, the mass ratio of Piper longum, Cortex Moutan and Angelica dahurica is 0.3-0.7:1.5-1.8:1.

[0023] Furthermore, the complex enzyme is a mixture of cellulase, pectinase and β-glucanase in a mass ratio of 1:0.2-0.6:1.4-1.9.

[0024] Furthermore, the mass of the complex enzyme accounts for 1-3% of the mass of the mixed powder.

[0025] The present invention can promote the anti-allergic effect of the first plant extract by adding the second plant extract. The active ingredients contained in the second plant extract can complement the first plant extract in terms of mechanism of action. The two can be used in combination to jointly combat the problem of tooth sensitivity from different angles. The components in the second plant extract increase the stability and bioavailability of the active ingredients of the first plant extract by changing the pH value of the oral environment, thereby enhancing the overall anti-allergic effect. At the same time, the second extract can improve the anti-inflammatory property of the toothpaste. The active ingredients produced by composite enzyme fermentation of Piper longum, Cortex Moutan and Angelica dahurica can have certain antibacterial and anti-inflammatory effects, can help alleviate the inflammatory response in the oral cavity, combat inflammatory states such as gingivitis and periodontitis caused by bacteria, and thus help improve the anti-inflammatory effect of the toothpaste. However, after adding the two plant extracts, the plant components in the system are complex, the stability of the toothpaste is not ideal, and the paste solid-liquid separation may occur.

[0026] Sodium guaiacyl sulfonate, CAS: 6223-35-4.

[0027] Furthermore, the thickener is at least one of xanthan gum, carrageenan or sodium carboxymethyl cellulose.

[0028] Furthermore, the moisturizing agent is at least one of glycerin, sorbitol or polyethylene glycol 400.

[0029] Furthermore, the foaming agent is a mixture of cocamidopropyl betaine, sodium lauryl sulfate and sodium lauroyl sarcosinate in a mass ratio of 0.3-0.6:1:1.2-1.5.

[0030] The present invention can improve the dispersibility and stability of toothpaste by using foaming agents with specific proportions and compositions. This may be because the combination of the above-mentioned foaming agents can exhibit the properties of cationic or anionic surfactants under different pH environments. This unique property enables it to stabilize the foam under the formulation conditions of this system and synergize with other components in this system to enhance the stability of the entire system, and further help the plant extract to mix better with other toothpaste ingredients to form a stable paste and prevent stratification or sedimentation.

[0031] Cocamidopropyl Betaine: CAS: 61789-40-0.

[0032] Sodium lauroyl sarcosinate: CAS number: 137-16-6.

[0033] The present invention also provides a method for preparing an anti-allergic cleaning toothpaste, which comprises the following steps: placing raw materials of the anti-allergic cleaning toothpaste in a blender at 500 rpm-700 rpm, stirring for 30 min-50 min, and vacuum degassing into a paste to obtain the anti-allergic cleaning toothpaste.

[0034] Compared with the prior art, the advantages and beneficial effects of the present invention are:

[0035] 1. The toothpaste of the present invention has good anti-sensitivity and anti-inflammatory effects and high storage stability. It is an anti-sensitivity toothpaste specially used for people who bleach their teeth with bleaching agents.

[0036] 2. The present invention can improve the anti-sensitivity of toothpaste by adding the first plant extract into the toothpaste, and has a good anti-sensitivity effect on people who have used bleaching agents to whiten their teeth.

[0037] 3. The present invention can promote the anti-allergic effect of the first plant extract by adding the second plant extract. At the same time, the second extract can improve the anti-inflammatory property of the toothpaste.

[0038] 4. The present invention can improve the stability of toothpaste by using a foaming agent with a specific ratio and composition. DETAILED DESCRIPTION

[0039] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0040] The enzymes and bacterial agents used in the present invention are all commercially available products, specifically:

[0041] β-glucanase, enzyme activity 40u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0042] Cellulase, enzyme activity 50u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0043] Neutral protease, enzyme activity 100u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0044] Pectinase, enzyme activity 50u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0045] Bromelain, enzyme activity 300u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0046] Fig proteinase, enzyme activity 300u / mg, Shanghai Yuanye Biotechnology Co., Ltd.

[0047] Lactobacillus furfur, with the deposit number SHBCC D24371JCM 2762, is deposited in Shanghai Microbiological Collection Center.

[0048] Lactobacillus acidophilus, with the deposit number of CCTCC DB 20081522, is deposited in China Center for Type Culture Collection.

[0049] Lactobacillus casei, with the deposit number of CCTCCAB 2013356, is deposited in China Center for Type Culture Collection.

[0050] Lactobacillus brevis, with the deposit number of CCTCC DB 20081559, is deposited in China Center for Type Culture Collection.

[0051] Example 1

[0052] The present embodiment provides an anti-sensitivity cleaning toothpaste, comprising the following raw materials in parts by mass: 22 parts of hydroxyapatite, 4 parts of sodium guaiacyl sulfonate, 4 parts of a first plant extract, 2 parts of a second plant extract, 7 parts of borneol, 5 parts of strontium chloride hexahydrate, 13 parts of silicon dioxide, 2 parts of a thickener, 4 parts of a moisturizer, 2 parts of a foaming agent, and 32 parts of deionized water.

[0053] The preparation method of the first plant extract is:

[0054] (1) Mixing agrimony, wild chrysanthemum, forsythia, and honeysuckle in a mass ratio of 1:1.3:0.6:1.8, and crushing to an average particle size of 60 meshes to obtain a traditional Chinese medicine powder;

[0055] (2) mixing the Chinese medicinal powder, water and Lactobacillus furfurali in a mass ratio of 1:9:0.15, performing anaerobic fermentation at a fermentation temperature of 32° C. and a fermentation time of 16 h, and sterilizing to obtain a first fermentation product;

[0056] (3) adding 0.25 times the mass of the Chinese medicine powder to the first fermentation product, performing anaerobic fermentation at a temperature of 32° C. for 13 h, and sterilizing to obtain a second fermentation product;

[0057] (4) filtering the second fermentation product to obtain a filtrate, and concentrating and drying the filtrate to obtain a first plant extract.

[0058] The preparation method of the second plant extract is:

[0059] (1) Piper longum, Cortex Moutan and Angelica dahurica are mixed in a mass ratio of 0.5:1.6:1, and crushed to an average particle size of 80 meshes to obtain a mixed powder.

[0060] (2) adding 7 times the mass of water to the mixed powder, heating and extracting at 65° C. for 2.5 h to obtain a water-extracted product;

[0061] (3) adding 2% of the weight of the mixed powder to the water-extracted product, wherein the mixed enzyme is a mixture of cellulase, pectinase and β-glucanase in a weight ratio of 1:0.4:1.7; immersing at 42°C for 13 hours for enzymolysis, and heating at 121°C for 15 minutes to inactivate the enzymes to obtain an enzymolysis solution;

[0062] (4) filtering the enzymatic hydrolyzate to obtain a filtrate, and concentrating and drying the filtrate to obtain a second plant extract.

[0063] The thickener is xanthan gum.

[0064] The humectant is glycerin.

[0065] The foaming agent is a mixture of cocamidopropyl betaine, sodium lauryl sulfate and sodium lauroyl sarcosinate in a mass ratio of 0.4:1:1.3.

[0066] The preparation method of the anti-allergic cleaning toothpaste comprises the following steps: placing the raw materials of the anti-allergic cleaning toothpaste in a mixer and stirring at 600 rpm for 40 minutes, vacuum degassing into a paste, and obtaining the anti-allergic cleaning toothpaste.

[0067] Example 2

[0068] The present embodiment provides an anti-sensitivity cleaning toothpaste, comprising the following raw materials in parts by mass: 20 parts of hydroxyapatite, 6 parts of sodium guaiacyl sulfonate, 2 parts of a first plant extract, 3 parts of a second plant extract, 5 parts of borneol, 9 parts of strontium chloride hexahydrate, 10 parts of silicon dioxide, 3 parts of a thickener, 2 parts of a moisturizer, 3 parts of a foaming agent and 30 parts of deionized water.

[0069] The preparation method of the first plant extract is:

[0070] (1) Mixing agrimony, wild chrysanthemum, forsythia, and honeysuckle in a mass ratio of 1:1.2:0.8:1.6, and grinding the mixture to an average particle size of 80 meshes to obtain a Chinese medicine powder;

[0071] (2) mixing the Chinese medicine powder, water and Lactobacillus furfur in a mass ratio of 1:8:0.1, performing anaerobic fermentation at a fermentation temperature of 35° C. and a fermentation time of 17 h, and sterilizing to obtain a first fermentation product;

[0072] (3) adding 0.2 times the weight of the Chinese medicine powder to the first fermentation product, performing anaerobic fermentation at a temperature of 35° C. for 12 h, and sterilizing to obtain a second fermentation product;

[0073] (4) filtering the second fermentation product to obtain a filtrate, and concentrating and drying the filtrate to obtain a first plant extract.

[0074] The preparation method of the second plant extract is:

[0075] (1) Piper longum, Cortex Moutan and Angelica dahurica are mixed in a mass ratio of 0.7:1.5:1, and crushed to an average particle size of 80 meshes to obtain a mixed powder.

[0076] (2) adding water 6 times the mass of the mixed powder to the mixed powder, heating and extracting at 70° C. for 3 h to obtain a water-extracted product;

[0077] (3) adding 1% of the weight of the mixed powder to the water-extracted product, wherein the mixed enzyme is a mixture of cellulase, pectinase and β-glucanase in a weight ratio of 1:0.2:1.9; immersing at 45°C for 12 hours for enzymolysis, and heating at 121°C for 15 minutes to inactivate the enzymes to obtain an enzymolysis solution;

[0078] (4) filtering the enzymatic hydrolyzate to obtain a filtrate, and concentrating and drying the filtrate to obtain a second plant extract.

[0079] The thickener is carrageenan.

[0080] The humectant is sorbitol.

[0081] The foaming agent is a mixture of cocamidopropyl betaine, sodium lauryl sulfate and sodium lauroyl sarcosinate in a mass ratio of 0.3:1:1.5.

[0082] The preparation method of the anti-allergic cleaning toothpaste comprises the following steps: placing the raw materials of the anti-allergic cleaning toothpaste in a mixer and stirring at 700 rpm for 30 minutes, vacuum degassing into a paste, and obtaining the anti-allergic cleaning toothpaste.

[0083] Comparative Example 1

[0084] The difference between this comparative example and Example 1 is that the first plant extract and the second plant extract are different in the proportions.

[0085] An anti-sensitivity cleaning toothpaste comprises the following raw materials in parts by mass: 22 parts of hydroxyapatite, 4 parts of sodium guaiacyl sulfonate, 1 part of a first plant extract, 5 parts of a second plant extract, 7 parts of borneol, 5 parts of strontium chloride hexahydrate, 13 parts of silicon dioxide, 2 parts of a thickener, 4 parts of a humectant, 2 parts of a foaming agent and 32 parts of deionized water.

[0086] Comparative Example 2

[0087] The difference between this comparative example and Example 1 is that the mass ratio of crane grass, wild chrysanthemum, forsythia and honeysuckle is 1:1:1:1.

[0088] Comparative Example 3

[0089] The difference between this comparative example and Example 1 is that different strains of bacteria are used in the preparation of the first plant extract.

[0090] The preparation method of the first plant extract is:

[0091] (1) Mixing agrimony, wild chrysanthemum, forsythia, and honeysuckle in a mass ratio of 1:1.3:0.6:1.8, and crushing the mixture to a particle size of less than 60 meshes to obtain a traditional Chinese medicine powder;

[0092] (2) mixing the Chinese medicine powder, water and Lactobacillus casei in a mass ratio of 1:9:0.15, performing anaerobic fermentation at a fermentation temperature of 32° C. and a fermentation time of 16 h, and sterilizing to obtain a first fermentation product;

[0093] (3) adding 0.25 times the weight of the Chinese medicine powder to the first fermentation product, performing anaerobic fermentation at a temperature of 32° C. for 13 h, and sterilizing to obtain a second fermentation product;

[0094] (4) filtering the second fermentation product to obtain a filtrate, and concentrating and drying the filtrate to obtain a first plant extract.

[0095] Comparative Example 4

[0096] The difference between this comparative example and Example 1 is that the mass ratio of Piper longum, Cortex Moutan and Angelica dahurica is 1:1:1.

[0097] Comparative Example 5

[0098] The difference between this comparative example and Example 1 is that the composite enzyme is a mixture of cellulase, pectinase and β-glucanase in a mass ratio of 1:1:1.

[0099] Comparative Example 6

[0100] The difference between this comparative example and Example 1 is that the composite enzyme is a mixture of neutral protease, bromelain and ficin in a mass ratio of 1:0.4:1.7.

[0101] Comparative Example 7

[0102] The difference between this comparative example and Example 1 is that the foaming agent is a mixture of cocamidopropyl betaine, sodium lauryl sulfate and sodium lauroyl sarcosinate in a mass ratio of 1:1:1.

[0103] Comparative Example 8

[0104] The difference between this comparative example and Example 1 is that the foaming agent is dodecyl dimethyl betaine (Haolong Chemical), sodium lauroyl glutamate (CAS29923-31-7) and sodium dodecyl sulfate in a mass ratio of 0.4:1:1.3.

[0105] Performance Testing

[0106] 1. According to the standard, 88 qualified subjects who used bleaching agents to bleach their teeth and suffered from tooth sensitivity were screened. The subjects complained of sensitivity to cold, hot, sour, and sweet stimuli, pain when biting hard objects, rapid onset, sharp pain, and short duration. Before the experiment, the subjects were confirmed by probes (sensitive to 10-50g tactile stimulation) and cold water stimulation. The subjects were divided into 11 groups with 8 people in each group, namely, Example 1-2 group, Comparative Example 1-8 group and blank group (blank group used normal saline to rinse their mouth). The subjects used the toothpaste prepared by the assigned embodiments and comparative examples to brush their teeth in the morning and evening for 2 weeks. After 2 weeks, the subjects went to the dental clinic for examination and evaluation.

[0107] Evaluation criteria: The sensitivity after cold stimulation was measured by blowing room temperature air onto the sensitive tooth surface using a three-purpose air gun on a dental comprehensive treatment chair. A standardized air stimulation method was used: at room temperature, the air gun on the dental comprehensive treatment table was used to blow air for 1 second at a distance of 1-1.5 cm from the sensitive tooth. The air temperature was 20±2°C. When blowing, the fingers were covered with the adjacent teeth to avoid the symptoms of the adjacent teeth affecting the accuracy of the results. Each tooth was examined once. The Schiff cold air sensitivity index was used for evaluation, and the scores were as follows: 0 = the tooth and the subject had no reaction to air stimulation; 1 = the tooth and the subject had a reaction to air stimulation, but did not request to stop the stimulation; 2 = the tooth and the subject had a reaction to air stimulation, and requested to stop the stimulation or remove the stimulation; 3 = the tooth and the subject had a reaction to air stimulation, the stimulation caused pain, and requested to stop.

[0108] Table 1 Performance test results

[0109]

[0110]

[0111] 2. Xylene-induced ear swelling test in mice.

[0112] Using the toothpaste of Examples 1-2 and Comparative Examples 1-8, mice were divided into 11 groups (including a control group), each group having 10 mice. After smearing one ear of the mouse with xylene to cause swelling, the swollen part of the ear of the mouse was smeared with an equal amount of the toothpaste, and the control group was smeared with an equal amount of physiological saline. After 2 hours, the swelling degree of the ear of each group of mice was measured, and the results are shown in Table 2.

[0113] Table 2 Test results

[0114]

[0115] 3. Refer to GB / T8372-2017 to determine the stability of toothpaste. The test conditions are:

[0116] The toothpaste was stored at -10℃, 25℃, and 40℃ for 3 months respectively, and then returned to room temperature to observe the paste state. At the same time, it was placed at -10℃, 25℃, and 40℃ for 10 days in sequence as a cycle, and a total of 3 cycles were used to measure the temperature stability. The results are shown in Table 3.

[0117] Table 3 Stability test results

[0118]

[0119]

[0120] It can be seen from the above performance test results that the toothpastes of Examples 1-2 have good anti-allergic and anti-inflammatory effects and high stability, especially the comprehensive performance of Example 1 is the most outstanding, which is mainly due to the synergistic effect of the raw materials of the toothpaste.

[0121] However, the comparative examples did not adopt the necessary technical solutions, resulting in corresponding performance tests that were significantly worse than those of the embodiments. In comparative example 1, the addition amounts of the two plant extracts were changed, and it can be seen that the anti-allergic and anti-inflammatory effects decreased, proving that the two components have a synergistic effect. The preparation methods of the two plant extracts in comparative examples 2-6 are different, and it can be seen from the results that this affects the anti-allergic and anti-inflammatory effects of the toothpaste. Comparative examples 7-8 show that the foaming agent affects the storage effect of the toothpaste. The above experimental results further prove the importance of the technical solution defined in the present invention for its technical effects.

[0122] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An anti-allergic cleaning toothpaste, characterized in that: The invention comprises the following raw materials in parts by weight: 20-25 parts of hydroxyapatite, 2-6 parts of sodium guaiacyl sulfonate, 2-5 parts of a first plant extract, 1-3 parts of a second plant extract, 5-10 parts of borneol, 4-9 parts of strontium chloride hexahydrate, 10-15 parts of silicon dioxide, 1-3 parts of a thickener, 2-5 parts of a moisturizing agent, 1-3 parts of a foaming agent and 30-35 parts of deionized water; The preparation method of the first plant extract is: (1) mixing agrimony, wild chrysanthemum, forsythia, and honeysuckle, and grinding the mixture to an average particle size of 60-80 meshes to obtain a Chinese medicine powder; (2) mixing the Chinese medicine powder, water and Lactobacillus furfurali in a mass ratio of 1:8-10:0.1-0.2, performing anaerobic fermentation at a fermentation temperature of 30-35° C. and a fermentation time of 15-17 h, and sterilizing to obtain a first fermentation product; (3) adding 0.2-0.3 times the mass of the Chinese medicine powder to the first fermentation product, performing anaerobic fermentation at a temperature of 30-35° C. for 12-14 h, and sterilizing to obtain a second fermentation product; (4) filtering the second fermentation product to obtain a filtrate, and concentrating and drying the filtrate to obtain a first plant extract; The mass ratio of agrimony, wild chrysanthemum, forsythia and honeysuckle is 1:1.2-1.4:0.5-0.8:1.6-1.9; The preparation method of the second plant extract is: (1) Mix Piper longum, Cortex Moutan and Angelica dahurica, and grind to an average particle size of 60-80 mesh to obtain a mixed powder. (2) adding 6-8 times the mass of water to the mixed powder, heating and extracting at 60-70° C. for 2-3 hours to obtain a water-extracted product; (3) adding a complex enzyme to the water extraction product, immersing the product at 40-45° C. for 12-15 h, and heating the product at 120-122° C. for 15-20 min to inactivate the enzyme, thereby obtaining an enzymatic solution; (4) filtering the enzymatic hydrolyzate to obtain a filtrate, and concentrating and drying the filtrate to obtain a second plant extract; The mass ratio of Piper longum, Cortex Moutan and Angelica dahurica is 0.3-0.7:1.5-1.8:1; The complex enzyme is a mixture of cellulase, pectinase and beta-glucanase in a mass ratio of 1:0.2-0.6:1.4-1.

9.

2. The anti-allergic cleaning toothpaste according to claim 1, characterized in that: The mass of the complex enzyme accounts for 1-3% of the mass of the mixed powder.

3. The anti-allergic cleaning toothpaste according to claim 1, characterized in that: The thickener is at least one of xanthan gum, carrageenan or sodium carboxymethyl cellulose.

4. The anti-allergic cleaning toothpaste according to claim 1, characterized in that: The moisturizing agent is at least one of glycerin, sorbitol or polyethylene glycol 400.

5. The anti-allergic cleaning toothpaste according to claim 1, characterized in that: The foaming agent is a mixture of cocamidopropyl betaine, sodium lauryl sulfate and sodium lauroyl sarcosinate in a mass ratio of 0.3-0.6:1:1.2-1.

5.

6. A method for preparing the anti-allergic cleaning toothpaste according to any one of claims 1 to 5, characterized in that: The preparation method comprises the following steps: placing the raw materials of the anti-allergic cleaning toothpaste in a mixer at 500 rpm to 700 rpm and stirring for 30 min to 50 min, and vacuum degassing into a paste to obtain the anti-allergic cleaning toothpaste.

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