A long-lasting stable selenium disulfide micropowder and its preparation method and application

Abstract

The present invention discloses a long-acting stable selenium disulfide micropowder, a preparation method and application thereof, and belongs to the technical field of encapsulated micropowders. The raw materials of the selenium disulfide micropowder of the present application include: 40-60 parts of wax, 30-50 parts of selenium disulfide and 1-10 parts of adsorbent; its application includes using the micropowder for antibacterial and anti-dandruff. The present invention makes selenium disulfide dispersed in the porous adsorbent by compounding selenium disulfide, wax and adsorbent, and uniformly coats the surface with wax. Wax can effectively protect the selenium disulfide active substance from the influence of external environmental factors, which is conducive to improving its stability and extending its validity period; the encapsulated selenium disulfide active substance can be released after rubbing, achieving a controlled release effect, allowing the active substance to be slowly released, thereby reducing possible toxic and side effects and improving bioavailability. At the same time, the preparation steps of the selenium disulfide micropowder provided by the present invention are simple, reducing the difficulty of industrial production, involving few auxiliary materials and all natural ingredients, and low toxicity.

Description

Technical Field

[0001] The invention belongs to the technical field of selenium disulfide micropowder, and in particular relates to a long-acting stable selenium disulfide micropowder and a preparation method and application thereof. Background Art

[0002] Dandruff is dead skin cells that fall off the surface of the scalp, usually appearing as small white or grayish-white flakes. Under normal circumstances, everyone will have dandruff, but when the dandruff increases abnormally, it is a skin disease. The causes of dandruff are usually the following: 1. The scalp is too dry, loses moisture, and the stratum corneum falls off too quickly; 2. Excessive sebum secretion stimulates the growth of scalp bacteria and accelerates the shedding of the stratum corneum; 3. Scalp infections such as fungal infections such as tinea capitis can also cause dandruff; 4. Incomplete shampooing or using inappropriate shampoo can cause accumulation of scalp residues, stimulating the production of dandruff; 5. Lack of nutrients such as vitamin B and zinc in the body can also cause dandruff problems.

[0003] The presence of dandruff can affect the health of the scalp and may cause problems such as scalp itching and inflammation. By removing dandruff, you can keep your scalp clean and reduce the occurrence of scalp problems. Dandruff will adhere to the hair, affecting the neatness and beauty of the hair. Regularly removing dandruff can keep the hair clean, reduce the greasy feeling of the hair, and improve the overall image and self-confidence.

[0004] Selenium disulfide is a compound commonly used to treat dandruff. Selenium disulfide can inhibit the growth of fungi (such as yeast) on the scalp and reduce the formation of dandruff. Selenium disulfide can also regulate the growth cycle of scalp cells, allowing scalp cells to shed better and reduce the accumulation of flakes. It regulates the sebum secretion of the scalp and reduces the excessive secretion of scalp oil, thereby reducing the formation of dandruff.

[0005] When selenium disulfide is used as an active ingredient in hair care products, there may be some formulation defects. For example, selenium disulfide itself has a special sulfur smell, which may bring an unpleasant smell to the product. In the formulation design, it is necessary to consider how to cover up or reduce the smell of selenium disulfide to enhance the product experience. Secondly, selenium disulfide may be unstable in some cases and easily lose its activity due to the influence of external environment such as light and oxygen. In order to ensure the effectiveness of the product, it is necessary to add appropriate stabilizers to the formula or take other measures to enhance the stability of selenium disulfide. The concentration of selenium disulfide affects the efficacy and safety of the product. Too high a concentration may cause adverse reactions such as dry scalp and irritation, while too low a concentration may affect the therapeutic effect of the product. Therefore, the concentration of selenium disulfide needs to be reasonably controlled in the formulation design to ensure the safety and effectiveness of the product.

[0006] A Chinese patent with publication number CN116019739 A discloses an anti-dandruff agent, a method for preparing the anti-dandruff agent and a daily chemical product, wherein selenium disulfide is loaded into the hydrophobic inner cavity of a water-soluble cyclodextrin. The encapsulated product of this technology may become unstable under changing environmental conditions, resulting in uncontrollable release rate of selenium disulfide, affecting its application effect.

[0007] A Chinese patent with publication number CN114788788 A discloses a selenium disulfide encapsulation technology and selenium disulfide shampoo. The surface of selenium disulfide powder is treated with a silane coupling agent to form an external organic chain end, which is then further cross-linked with silicone oil to form an encapsulation. This may protect the core material, but there may also be the following problems: if some areas are over-crosslinked or not completely cross-linked, the performance and stability of the material will be affected; silicone oil as an encapsulation layer may have brittle problems, especially under low or high temperature conditions, it is easy to crack or break, affecting the service life of the material. If there is any residual silicone oil that is not cleaned up, it may cause skin allergic reactions. Summary of the invention

[0008] In order to overcome the defects of the prior art, the present invention adds the adsorbent to the system. Under the appropriate temperature and stirring conditions, the tiny pores on the surface of the adsorbent can provide a large amount of surface area, so that the molecules of selenium disulfide can be attached to the surface and pores by physical adsorption. The porous surface of the porous material may generate van der Waals forces with the selenium disulfide molecules, effectively fixing the selenium disulfide on the microcrystalline cellulose, and then the wax forms a uniform encapsulation layer on the surface of the porous material to protect the inner core. After the raw materials are dried and mixed by a low-temperature granulator, they enter a rotating bed in a low-temperature environment, and low-temperature air is sprayed from the bottom of the bed. Using a spray system, the raw materials can be sprayed on the surface of the bed to form a liquid film, and the initial triangular or circular control of solidification is completed, and then after air cooling, the liquid gradually solidifies into particles.

[0009] In order to achieve the above purpose, the following technical solutions are adopted:

[0010] The invention provides a long-acting stable encapsulated selenium disulfide micropowder, which comprises the following components in parts by weight: 40 to 60 parts of wax, 30 to 50 parts of selenium disulfide and 1 to 10 parts of an adsorbent.

[0011] Furthermore, the wax is one or more of synthetic wax, carnauba wax, paraffin wax, microcrystalline wax, candelilla wax, white beeswax, liquid paraffin, and beeswax.

[0012] Wax is an oil produced by animals, plants or minerals. It is solid at room temperature, plastic, easy to melt, insoluble in water, soluble in benzene, etc. It is a fatty acid ester of monohydroxy alcohol or sterol and has a certain lubricating effect.

[0013] Furthermore, the adsorbent is one or more of kaolin, bentonite, montmorillonite, activated carbon, microcrystalline cellulose, and illite mica.

[0014] Diatomaceous Earth: Diatomaceous Earth is composed of diatom fossils. It has porosity and a high specific surface area. It is often used to absorb skin oils and in cleaning products.

[0015] Kaolin Clay: Kaolin is a natural clay with good adsorption and oil absorption properties. It is often used in facial masks and cleansing products to help remove dead skin cells and excess oil.

[0016] Bentonite Clay: Bentonite is a highly absorbent clay that draws impurities and toxins from the skin's surface.

[0017] Montmorillonite Clay: Montmorillonite is a layered clay mineral with excellent adsorption properties and can be used as an adsorbent and stabilizer in cosmetics.

[0018] Activated carbon is a carbon material with a highly porous structure, known for its strong adsorption capacity, capable of absorbing and removing impurities, grease, odors, etc.

[0019] Microcrystalline cellulose has a large specific surface area, strong adsorption capacity, excellent and mild cleaning effect; microcrystalline cellulose can form a gel with good suspension and atomization effects under certain conditions in water.

[0020] Hydromica has good adsorption properties and can absorb oil and dirt on the skin surface. Due to the stable chemical properties of Hydromica, it can be used as a stabilizer to improve the stability of cosmetics.

[0021] The present invention also provides a method for preparing long-acting stable encapsulated selenium disulfide micropowder, comprising the following steps:

[0022] (1) Melting the wall material: heating the wax to a molten state to make it liquid so as to encapsulate the active substance, and setting the stirring speed to ensure uniform stirring to obtain a wax solution;

[0023] (2) adsorbent mixing: adding the adsorbent to the wax solution to obtain a mixed solution A;

[0024] (3) Active material mixing: adding the active material selenium disulfide to the mixed solution A in step 2 in 3 to 5 portions to ensure that the selenium disulfide is fully adsorbed into the porous material, and then slowly lowering the temperature to obtain a mixture B;

[0025] (4) low temperature granulation: subjecting the mixture B in step (3) to low temperature granulation to ensure that the particles are rapidly solidified to form solid particles;

[0026] (5) Screening of particles: Screen the particles using a 20-mesh sieve, retain the particles under the sieve, and then screen the particles under the sieve using an 80-mesh sieve, retain the particles above the sieve, and obtain long-lasting and stable encapsulated selenium disulfide micropowder.

[0027] Preferably, the ratio of the adsorbent to selenium disulfide is (1-10):(30-50).

[0028] More preferably, the ratio of the adsorbent to selenium disulfide is (1-4):(35-45).

[0029] Most preferably, the ratio of the adsorbent to selenium disulfide is 2:40.

[0030] Furthermore, the melting temperature in step (1) is 50° C. to 85° C., the heating time is 30 to 60 min, and the stirring speed is 100 to 500 rpm.

[0031] Furthermore, in the adding process in step (3), the stirring speed is set at 200 to 300 rpm, and the temperature is maintained at 60° C. to 65° C., and the stirring is performed for 10 to 30 minutes.

[0032] Furthermore, the temperature in step (3) is slowly reduced to 30-40°C.

[0033] Furthermore, in the step 4, the feed rate of the low-temperature granulation treatment is 5-20 kg / h, the drum speed is 100-500 rpm, the working pressure is 5-20 bar, and the cooling temperature is -20°C to 10°C.

[0034] The present invention also provides the application of long-acting stable encapsulated selenium disulfide micropowder: the micropowder is used for antibacterial and anti-dandruff.

[0035] The beneficial effects of the present invention are:

[0036] (1) Uniform encapsulation: Selenium disulfide is dispersed in the porous adsorbent through the action of the adsorbent, and then the wax is uniformly coated on the surface.

[0037] (2) Good stability: Wax can effectively protect the active ingredient of selenium disulfide from the influence of external environmental factors, such as oxygen and moisture, thereby improving its stability and extending its shelf life.

[0038] (3) Controlled release effect: The encapsulated selenium disulfide active ingredient can be released after rubbing, achieving a controlled release effect, allowing the active ingredient to be released slowly, thereby reducing possible toxic side effects and improving bioavailability.

[0039] (4) The preparation steps of the selenium disulfide micropowder involved in the present invention are simple, which reduces the difficulty of industrial production.

[0040] (5) The present invention involves few auxiliary materials, and all of them are natural ingredients with low toxicity. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 The particle size determination test results of the selenium disulfide micropowder of the present invention;

[0042] Figure 2 These are photos of the scalp of volunteer A before and after using Example 1;

[0043] Figure 3 These are photos of the scalp of volunteer B before and after using Example 1.

[0044] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0045] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0046] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0047] The experimental methods in the following examples are conventional methods unless otherwise specified, and the experimental materials used in the following examples are purchased from commercial channels unless otherwise specified.

[0048] Example 1

[0049] This embodiment provides a method for preparing a long-lasting and stable encapsulated selenium disulfide micropowder, comprising the following steps:

[0050] (1) Melting the wall material: 20 parts of candelilla wax and 30 parts of liquid paraffin were heated at 85° C. for 40 min until they were melted and turned into a liquid state to facilitate encapsulation of the active substance. At the same time, the stirring speed was set at 300 rpm to ensure uniform stirring, thereby obtaining a wax solution;

[0051] (2) Adsorbent mixture: 3 parts of kaolin were added to the wax solution to obtain a mixed solution A;

[0052] (3) Active material mixing: 30 parts of active material selenium disulfide were added to the mixed solution A in step 2 in three times to ensure that selenium disulfide was fully adsorbed into the porous material. The stirring speed was set at 200 rpm during the addition process, and the temperature was maintained at 60° C. for 30 minutes, and then the temperature was slowly reduced to 40° C. to obtain a mixture B;

[0053] (4) Low temperature granulation: The feed rate was set at 10 kg / h, the drum speed was 200 rpm, the working pressure was 15 bar, and the cooling temperature was -10 °C, and the mixture B in step 4 was treated to ensure that the particles were quickly solidified to form solid particles;

[0054] (5) Screening of particles: Screen the particles using a 20-mesh sieve, retain the particles under the sieve, and then screen the particles under the sieve using an 80-mesh sieve, retain the particles above the sieve, and obtain long-lasting and stable encapsulated selenium disulfide micropowder.

[0055] Example 2

[0056] This embodiment provides a method for preparing a long-lasting and stable encapsulated selenium disulfide micropowder, comprising the following steps:

[0057] (1) Melting the wall material: 30 parts of carnauba wax and 20 parts of white beeswax were heated at 85° C. for 40 min until they were melted and turned into a liquid state to facilitate encapsulation of the active substance. At the same time, the stirring speed was set at 300 rpm to ensure uniform stirring, thereby obtaining a wax solution;

[0058] (2) Adsorbent mixture: 4 parts of Illy hydromica were added to the wax solution to obtain a mixed solution A;

[0059] (3) Active material mixing: 40 parts of active material selenium disulfide were added to the mixed solution A in step 2 in three portions to ensure that selenium disulfide was fully adsorbed into the porous material. During the adding process, the stirring speed was set at 200 rpm, the temperature was maintained at 60° C., and the stirring was continued for 30 minutes. Then the temperature was slowly reduced to 40° C. to obtain a mixture B.

[0060] (4) Low temperature granulation: The feed rate was set at 10 kg / h, the drum speed was 200 rpm, the working pressure was 15 bar, and the cooling temperature was -10 °C, and the mixture B in step 4 was treated to ensure that the particles were quickly solidified to form solid particles;

[0061] (5) Screening of particles: Screen the particles using a 20-mesh sieve, retain the particles under the sieve, and then screen the particles under the sieve using an 80-mesh sieve, retain the particles above the sieve, and obtain long-lasting and stable encapsulated selenium disulfide micropowder.

[0062] Example 3

[0063] This embodiment provides a method for preparing a long-lasting and stable encapsulated selenium disulfide micropowder, comprising the following steps:

[0064] (1) Melting the wall material: 25 parts of microcrystalline wax and 25 parts of synthetic wax were heated at 85° C. for 40 min until they were melted and turned into a liquid state to facilitate encapsulation of the active substance. At the same time, the stirring speed was set at 300 rpm to ensure uniform stirring, thereby obtaining a wax solution;

[0065] (2) Adsorbent mixture: 5 parts of activated carbon were added to the wax solution to obtain a mixed solution A;

[0066] (3) Active material mixing: 50 parts of active material selenium disulfide were added to the mixed solution A in step 2 in three portions to ensure that selenium disulfide was fully adsorbed into the porous material. During the addition process, the stirring speed was set at 200 rpm, the temperature was maintained at 60° C., and the stirring was continued for 30 minutes. Then the temperature was slowly reduced to 40° C. to obtain a mixture B.

[0067] (4) Low temperature granulation: The feed rate was set at 10 kg / h, the drum speed was 200 rpm, the working pressure was 15 bar, and the cooling temperature was -10 °C, and the mixture B in step 4 was treated to ensure that the particles were quickly solidified to form solid particles;

[0068] (5) Screening of particles: Screen the particles using a 20-mesh sieve, retain the particles under the sieve, and then screen the particles under the sieve using an 80-mesh sieve, retain the particles above the sieve, and obtain long-lasting and stable encapsulated selenium disulfide micropowder.

[0069] Example 4

[0070] This embodiment provides a method for preparing a long-lasting and stable encapsulated selenium disulfide micropowder, comprising the following steps:

[0071] (1) Melting the wall material: 40 parts of beeswax and 10 parts of paraffin wax were heated at 75°C for 40 min until they were melted and turned into a liquid state to facilitate encapsulation of the active substance. At the same time, the stirring speed was set at 300 rpm to ensure uniform stirring, thereby obtaining a wax solution;

[0072] (2) Adsorbent mixture: 2 parts of microcrystalline cellulose were added to the wax solution to obtain a mixed solution A;

[0073] (3) Active material mixing: 40 parts of active material selenium disulfide were added to the mixed solution A in step 2 in three portions to ensure that selenium disulfide was fully adsorbed into the porous material. During the adding process, the stirring speed was set at 200 rpm, the temperature was maintained at 60° C., and the stirring was continued for 30 minutes. Then the temperature was slowly reduced to 40° C. to obtain a mixture B.

[0074] (4) Low temperature granulation: The feed rate was set at 10 kg / h, the drum speed was 200 rpm, the working pressure was 15 bar, and the cooling temperature was -10 °C, and the mixture B in step 4 was treated to ensure that the particles were quickly solidified to form solid particles;

[0075] (5) Screening of particles: Screen the particles using a 20-mesh sieve, retain the particles under the sieve, and then screen the particles under the sieve using an 80-mesh sieve, retain the particles above the sieve, and obtain long-lasting and stable encapsulated selenium disulfide micropowder.

[0076] Example 5

[0077] This embodiment provides a method for preparing long-lasting stable encapsulated selenium disulfide micropowder, which has the same formulation as that of Example 4, except that the stirring speed in step (3) is 300 rpm.

[0078] Example 6

[0079] This embodiment provides a method for preparing long-lasting stable encapsulated selenium disulfide micropowder, which has the same formula as that of Example 4, except that the low-temperature granulation feed rate in step (4) is 20 kg / h and the working pressure is 5 bar.

[0080] Example 7

[0081] This embodiment provides a method for preparing long-acting stable encapsulated selenium disulfide micropowder, which has the same formula as that of Example 4, except that the low-temperature granulation cooling temperature in step (4) is -20°C.

[0082] Example 8

[0083] The present embodiment provides a method for preparing a long-acting stable encapsulated selenium disulfide micropowder, specifically, using a 40-mesh sieve to sieve the particles, retaining the undersieve portion, and then using a 60-mesh sieve to sieve the particles under the sieve, retaining the oversieve portion, to obtain a long-acting stable encapsulated selenium disulfide micropowder.

[0084] Comparative Example 1

[0085] In this comparative example, no adsorbent is added, and the preparation process comprises the following steps:

[0086] (1) Melting the wall material: 40 parts of beeswax and 10 parts of paraffin wax were heated at 75°C for 40 min until they were melted and turned into a liquid state to facilitate encapsulation of the active substance. At the same time, the stirring speed was set at 300 rpm to ensure uniform stirring, thereby obtaining a wax solution;

[0087] (2) Active ingredient mixing: 40 parts of active ingredient selenium disulfide was added to the wax solution in three portions. The stirring speed was set at 200 rpm during the addition process. The temperature was maintained at 60° C. and stirred for 30 minutes. Then the temperature was slowly reduced to 40° C. to obtain a mixture B.

[0088] (3) Low temperature granulation: The feed rate was set at 10 kg / h, the drum speed was 200 rpm, the working pressure was 15 bar, and the cooling temperature was -10 °C, and the mixture B in step 4 was treated to ensure that the particles were quickly solidified to form solid particles;

[0089] (4) Screening of particles: Screen the obtained particles using a 20-mesh sieve to obtain selenium disulfide micropowder.

[0090] Comparative Example 2

[0091] This comparative example does not use low-temperature granulation, and the preparation process includes the following steps:

[0092] (1) Melting the wall material: 40 parts of beeswax and 10 parts of paraffin wax were heated at 75°C for 40 min until they were melted and turned into a liquid state to facilitate encapsulation of the active substance. At the same time, the stirring speed was set at 300 rpm to ensure uniform stirring, thereby obtaining a wax solution;

[0093] (2) Adsorbent mixture: 2 parts of microcrystalline cellulose were added to the wax solution to obtain a mixed solution A;

[0094] (3) Active material mixing: 40 parts of active material selenium disulfide were added to the mixed solution A in step 2 in three portions to ensure that selenium disulfide was fully adsorbed into the porous material. During the adding process, the stirring speed was set at 200 rpm, the temperature was maintained at 60° C., and the stirring was continued for 30 minutes. Then the temperature was slowly reduced to 40° C. to obtain a mixture B.

[0095] (4) Granulation: The mixture is cooled to a solid state, and the solid mixture is crushed into granules using a pulverizer;

[0096] (5) Screening of particles: Screen the obtained particles using a 20-mesh sieve to obtain selenium disulfide micropowder.

[0097] Comparative Example 3

[0098] In this comparative example, selenium disulfide is not loaded, and the preparation process comprises the following steps:

[0099] (1) Melting the wall material: 40 parts of beeswax and 10 parts of paraffin wax were heated at 75°C for 40 min until they were melted and turned into a liquid state to facilitate encapsulation of the active substance. At the same time, the stirring speed was set at 300 rpm to ensure uniform stirring, thereby obtaining a wax solution;

[0100] (2) Adsorbent mixture: 2 parts of microcrystalline cellulose were added to the wax solution, the stirring speed was set to 200 rpm, the temperature was maintained at 60° C., and the mixture was stirred for 30 min, and then the temperature was slowly reduced to 40° C. to obtain a mixture;

[0101] (3) Low temperature granulation: set the feed rate at 10 kg / h, the drum speed at 200 rpm, the working pressure at 15 bar, and the cooling temperature at -10 °C to process the mixture in step 4 to ensure that the particles are quickly solidified to form solid particles;

[0102] (4) Screening of particles: Screen the particles using a 20-mesh sieve, retain the particles under the sieve, and then screen the particles under the sieve using an 80-mesh sieve, retain the particles above the sieve, and thus obtain encapsulated micropowder.

[0103] Comparative Example 4

[0104] In this comparative example, the components are mixed together, and the preparation process comprises the following steps:

[0105] (1) adding 40 parts of beeswax, 10 parts of paraffin, 2 parts of microcrystalline cellulose, and 40 parts of selenium disulfide into a unified system, heating at 75° C. for 40 min until the mixture is melted, setting the stirring speed at 300 rpm to ensure uniform stirring, and then slowly reducing the temperature to 40° C. to obtain a mixture;

[0106] (2) Low temperature granulation: The feed rate was set at 10 kg / h, the drum speed was 200 rpm, the working pressure was 15 bar, and the cooling temperature was -10 °C. The mixture in step 4 was treated to ensure that the particles were quickly solidified to form solid particles.

[0107] (3) Screening of particles: Screen the particles using a 20-mesh sieve, retain the part under the sieve, and then screen the particles under the sieve using an 80-mesh sieve, retain the part above the sieve, and thus obtain long-lasting and stable encapsulated selenium disulfide micropowder.

[0108] Test Example 1: Particle size measurement test

[0109] 1. Test samples: the formulation of Example 1, the formulation of Example 2, the formulation of Example 3, and the formulation of Example 4.

[0110] 2. Test method: Measured by laser particle size analyzer.

[0111] 3. Test results: see Figure 1The particle size is 25 μm.

[0112] Test Example 2: Stability Test

[0113] 1. Test samples: the formulation of Example 1, the formulation of Example 2, the formulation of Example 3, the formulation of Example 4, the formulation of Comparative Example 1, and the formulation of Comparative Example 2.

[0114] 2. Test method: Place the test samples in dry, transparent glass bottles and seal them in a stability test box.

[0115] 3. Test results: see Table 1.

[0116] Table 1: Selenium disulfide powder stability test results

[0117]

[0118] Test Example 3: Antibacterial effect evaluation test

[0119] 1. Test samples: the formulation of Example 1, the formulation of Example 2, the formulation of Example 3, the formulation of Example 4, the formulation of Comparative Example 1, and the formulation of Comparative Example 2.

[0120] 2. Test method: 1g of selenium disulfide powder obtained in the embodiment and comparative example was added to 20ml of Malassezia furfur suspension for mixing, and a blank control test was performed at the same time. Then, the culture medium was added and cultured at 30°C for 4 days, and the colonies were counted and the inhibition rate was calculated, the inhibition rate = (the average colony number of the control group - the average colony number of the test group) / the average colony number of the control group × 100%.

[0121] 3.Evaluation results: See Table 2.

[0122] Table 2: Results of the evaluation test on the antibacterial effect of selenium disulfide micropowder

[0123]

[0124] Test Example 4: Evaluation of Antidandruff Effect

[0125] 1. Test sample: According to the content of selenium disulfide in shampoo products, selenium disulfide anti-dandruff samples were prepared using Example 1 and Comparative Example 2, and the components included: 1.0% selenium disulfide, 0.5% panthenol, 0.5% salicylic acid, 0.2% disodium edetate, 20% surfactant, 5.0% hair conditioner, 0.9% preservative and 0.2% pH adjuster.

[0126] 2. Test method: One hundred volunteers with dandruff were divided into two groups, 50 in each group. They were asked to use the anti-dandruff sample of the test sample twice a week. The safety and anti-dandruff efficacy were evaluated based on the volunteers' experience. The anti-dandruff efficacy standards were as follows: (1) Effective: significant anti-dandruff effect; (2) Poor: average or no effect; (3) Poor: redness, swelling, itching, or unpleasant odor.

[0127] 3.Evaluation results: See Table 3.

[0128] Figure 2 , Figure 3 The scalp pictures of two volunteers before and after using Example 1 are taken, with the left side being before use and the right side being after use. The results in the picture show that the selenium disulfide sample prepared by using the long-acting stable encapsulated selenium disulfide micropowder of the present invention can significantly reduce the dandruff rate.

[0129] Table 3: Evaluation of the anti-dandruff effect of selenium disulfide micropowder

[0130] product efficient Poor Poor Anti-dandruff sample of Example 1 30 16 4 Anti-dandruff sample of comparative example 2 19 25 6

[0131] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0132] The present invention and its implementation methods are described above, which is not restrictive. The drawings are only one of the implementation methods of the present invention, and the actual application is not limited thereto. In short, if ordinary technicians in the field are inspired by it and design methods and embodiments similar to the technical solution without creativity without departing from the purpose of the invention, they should all fall within the protection scope of the present invention.

Claims

1. A long-lasting stable encapsulated selenium disulfide micropowder, characterized in that: The method comprises the following raw material components in parts by weight: 40-60 parts of wax, 30-50 parts of selenium disulfide and 1-10 parts of an adsorbent; The wax is one or more of synthetic wax, carnauba wax, paraffin wax, microcrystalline wax, candelilla wax, white beeswax, liquid paraffin, and beeswax; the adsorbent is one or more of kaolin, activated carbon, microcrystalline cellulose, and Illy hydromica, and the ratio of the adsorbent to selenium disulfide is (1-10):(30-50); and The long-acting stable encapsulated selenium disulfide micropowder is prepared according to the following steps: (1) Melting the wall material: heating the wax to a molten state to make it liquid so as to encapsulate the active substance, and setting the stirring speed to ensure uniform stirring to obtain a wax solution; (2) adsorbent mixing: adding the adsorbent to the wax solution to obtain a mixed solution A; (3) Active material mixing: adding the active material selenium disulfide to the mixed solution A in step (2) in 3 to 5 portions to ensure that the selenium disulfide is fully adsorbed into the porous material, and then slowly lowering the temperature to obtain a mixture B; (4) low temperature granulation: the mixture B in step (3) is subjected to low temperature granulation treatment to ensure that the particles are quickly solidified to form solid particles, wherein the feed rate of the low temperature granulation treatment is 5-20 kg / h, the drum speed is 100-500 rpm, the working pressure is 5-20 bar, and the cooling temperature is -20°C to 10°C; (5) Screening of particles: Screen the particles using a 20-mesh sieve, retain the particles under the sieve, and then screen the particles under the sieve using an 80-mesh sieve, retain the particles above the sieve, and obtain long-lasting and stable encapsulated selenium disulfide micropowder.

2. The long-acting stable encapsulated selenium disulfide micropowder according to claim 1, characterized in that: The ratio of the adsorbent to selenium disulfide is (1-4):(35-45).

3. The long-acting stable encapsulated selenium disulfide micropowder according to claim 2, characterized in that: The ratio of the adsorbent to selenium disulfide is 2:

40.

4. The long-acting stable encapsulated selenium disulfide micropowder according to claim 3, characterized in that: The melting temperature in step (1) is 50-85° C., the heating time is 30-60 min, and the stirring speed is 100-500 rpm.

5. The long-acting stable encapsulated selenium disulfide micropowder according to claim 4, characterized in that: The adding process in step (3) is performed at a stirring speed of 200-300 rpm, and the stirring is maintained at a temperature of 60° C.-65° C. for 10-30 min.

6. The long-acting stable encapsulated selenium disulfide micropowder according to claim 5, characterized in that: The temperature in step (3) is slowly reduced to 30-40°C.

7. An application of the long-acting stable encapsulated selenium disulfide micropowder according to any one of claims 1 to 6, characterized in that: The micro powder is used for preparing antibacterial and anti-dandruff shampoo preparations.

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