Device for real-time dilution detection in continuous cycler for peritoneal dialysis

Abstract

The application discloses an access type peritoneal dialysis real-time dilution detection device, which comprises a drainage unit, a dilution unit, a mixing unit, a detection unit and an abdominal pressure instrument; the dilution unit and the mixing unit are connected through a catheter; the mixing unit and the detection unit are connected through a catheter; the drainage unit comprises a sterile bag, a catheter placement device, a fine catheter and a buckle; the buckle is arranged at a first outlet end of the sterile bag and is fixedly installed in the sterile bag; the catheter placement device is located at a second outlet end of the sterile bag and is fixedly installed in the sterile bag; two ends of the two fine catheters pass through the catheter placement device; one end of one fine catheter is connected with the peristaltic pump of the mixing unit through the first outlet, and the other end of the other fine catheter is connected with the abdominal pressure instrument through the first outlet. The access type peritoneal dialysis real-time dilution detection device reduces the glucose concentration to the linear detection range of a commercially available glucose detector through real-time dilution, and there is no need to develop and test a higher-range glucose detector.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of medical devices, and particularly relates to an access type peritoneal dialysis real-time dilution detection device. BACKGROUND

[0002] Peritoneal dialysis is to pour dialysis fluid into the abdominal cavity through a catheter, use the peritoneum as a dialysis membrane, exchange solutes and water, remove metabolic products and excess water in the body, and achieve the purpose of kidney replacement therapy. At present, when using an automatic peritoneal dialysis machine (APD) for treatment, the dialysis catheter is connected to the pipeline of the machine, and the cycle of pouring and removing dialysis fluid is continuously carried out.

[0003] With the development of information technology, intelligent dialysis has great prospects. Real-time detection of the glucose concentration in the abdominal cavity of patients and abdominal pressure during real peritoneal dialysis is an important link to realize intelligent peritoneal dialysis. During the process of detecting the glucose concentration, it is found that the glucose concentration in the abdominal cavity of peritoneal dialysis patients far exceeds the linear detection range of commercially available glucose detectors. SUMMARY

[0004] In view of the above problems, the present application discloses an access type peritoneal dialysis real-time dilution detection device, which comprises a drainage unit, a dilution unit, a mixing unit, a detection unit and an abdominal pressure meter.

[0005] The dilution unit and the mixing unit are connected by a catheter.

[0006] The mixing unit and the detection unit are connected by a catheter.

[0007] The drainage unit comprises a sterile bag, a catheter placement device, a fine catheter and a buckle.

[0008] One end of the sterile bag is provided with a first outlet, and the other end is provided with a second outlet.

[0009] The buckle is arranged at the first outlet end of the sterile bag and fixedly installed in the sterile bag.

[0010] The catheter placement device is located at the second outlet end of the sterile bag and fixedly installed in the sterile bag.

[0011] One end of the two fine catheters passes through the catheter placement device.

[0012] The other end of one of the fine catheters is connected to the mixing unit through the first outlet, and the other end of the other fine catheter is connected to the abdominal pressure meter through the first outlet.

[0013] The abdominal pressure meter is used for real-time detection of abdominal pressure, and the detection unit is used for real-time detection of the glucose concentration in the solution diluted by the mixing unit.

[0014] Further, the catheter placement device comprises a housing, a catheter placement inlet, a catheter placement outlet, a sensor, a roller conveyor, an adjustable length button, a display screen, an indicator light, a catheter placement button, a catheter removal button and a catheter placement channel;

[0015] The housing is a cuboid;

[0016] The catheter placement inlet and the catheter placement outlet are respectively arranged on the two corresponding side walls of the housing, and the catheter placement channel is formed between the two;

[0017] The sensor is arranged at the catheter placement outlet;

[0018] The roller conveyors are respectively arranged on both sides of the catheter placement channel;

[0019] The adjustable length button, the display screen, the indicator light, the catheter placement button, the catheter removal button and the catheter placement inlet are arranged on the same side wall of the housing.

[0020] Further, it further comprises a Y-shaped connecting catheter;

[0021] The Y-shaped connecting catheter comprises a machine end connector, a patient end connector and a catheter end connector;

[0022] The machine end connector is connected with an automatic peritoneal dialysis machine;

[0023] The patient end connector is connected with a peritoneal dialysis catheter;

[0024] The catheter end connector is connected with a second outlet of a sterile bag.

[0025] Further, the dilution unit comprises a dilution liquid bottle, a dilution liquid catheter and a water purifier;

[0026] One end of the dilution liquid catheter is connected with the dilution liquid bottle, and the other end is connected with the mixing unit;

[0027] One end of the water purifier is connected with the dilution liquid bottle.

[0028] Further, the number of the dilution liquid catheters is not less than 4.

[0029] Further, the placement fine catheter is a silica gel tube with an inner diameter not greater than 1mm.

[0030] Further, the mixing unit comprises a peristaltic pump and a heating oscillator;

[0031] The peristaltic pump is respectively connected with the placement fine catheter and the dilution unit;

[0032] The peristaltic pump is connected with the heating oscillator.

[0033] Further, the detection unit comprises a self-power generation detection sensor module, a waste liquid cylinder and an electronic scale;

[0034] The inlet of the self-power generation detection sensor module is connected with the mixing unit, and the outlet is connected with the waste liquid cylinder.

[0035] The waste liquid cylinder is arranged on the electronic scale.

[0036] Further, the terminal server is further connected with the self-power generation detection sensor module, the abdominal pressure instrument, the electronic scale and the automatic peritoneal dialysis machine.

[0037] The terminal server is further connected with the self-power generation detection sensor module, the abdominal pressure instrument, the electronic scale and the automatic peritoneal dialysis machine.

[0038] Further, the dilution unit comprises a water purifier, a dilution liquid bottle, a dilution liquid conduit and a conical container.

[0039] The conical container is conical, the side wall is provided with a plurality of conduit interfaces, and the top point is provided with an outlet; wherein the plurality of conduit interfaces are located at the same height and are arranged at equal intervals.

[0040] The water purifier is connected with the dilution liquid bottle.

[0041] The dilution liquid bottle is connected with the conduit interfaces of the side wall of the conical container through the dilution liquid conduit.

[0042] The inserted thin conduit is connected with the conduit interfaces of the side wall of the conical container.

[0043] The outlet of the conical container is connected with the mixing unit.

[0044] Compared with the prior art, the embodiments of the present application have at least the following advantages:

[0045] 1) The access type peritoneal dialysis real-time dilution detection device of the present application can be used with multiple automatic peritoneal dialysis machines, is more conducive to popularization, and has lower cost.

[0046] 2) The glucose concentration is reduced to the linear detection range of a commercially available glucose detector by real-time dilution, without the need to develop and test a glucose detector that can detect in real time.

[0047] 3) The present application sets a water purifier to prevent different water qualities from affecting the results, and sets a heating oscillator to heat the liquid to body temperature (37℃), ensuring that the glucose detector can detect, and using a temperature sensor to ensure the temperature of the liquid, making the measured glucose concentration value more accurate.

[0048] 4) The present application sets a self-power generation detection sensor module to supply power while detecting the liquid temperature to ensure the accuracy of glucose detection, and sets a battery to use solar and electrical power for dual power supply, saving power resources.

[0049] 5) Based on the collected data, subsequent big data peritoneal dialysis glucose concentration and abdominal pressure model construction can be carried out, and remote intelligent peritoneal dialysis is realized through a remote operation system.

[0050] Other features and advantages of the present application will be set forth in the following description, and in part will become apparent to those skilled in the art from the description, or can be learned by practice of the present application. The objects and other advantages of the present application can be realized and attained by the structure particularly pointed out in the description and the accompanying drawings. BRIEF DESCRIPTION OF DRAWINGS

[0051] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, the drawings in the following description are some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained from these drawings without creative labor.

[0052] Figure 1 The structure schematic diagram of the access type peritoneal dialysis real-time dilution detection device according to the embodiment of the present application is shown;

[0053] Figure 2 The structure schematic diagram of the catheter placement device according to the embodiment of the present application is shown;

[0054] Figure 3 The structure schematic diagram of the dilution unit according to the embodiment of the present application is shown;

[0055] Figure 4 The connection schematic diagram of the plurality of peristaltic pumps according to the embodiment of the present application is shown.

[0056] The figure mark: 1, Y type connection catheter; 2, machine end connector; 3, patient end connector; 4, catheter end connector; 5, sterile bag; 6, buckle switch; 7, catheter placement device; 71, shell; 72, catheter placement inlet; 73, catheter placement outlet; 74, sensor; 75, roller conveyor belt; 76, length adjustment button; 77, display screen; 78, indicator light; 79, catheter placement button; 710, catheter removal button; 711, catheter placement channel; 8, placement thin catheter; 9, buckle; 10, first outlet; 11, peristaltic pump; 12, dilution liquid bottle; 13, dilution liquid catheter; 14, heating oscillator; 15, self-power generation detection sensor module; 16, waste liquid cylinder; 17, electronic scale; 18, terminal server; 19, automatic peritoneal dialysis machine; 20, conical container; 21, second outlet; 22, flow rate sensor; 23, detection catheter; 24, abdominal pressure instrument; 25, water purifier; 26, shell; 27, battery; 28, power cord; 29, solar panel. DETAILED DESCRIPTION

[0057] In order to make the purposes, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are some but not all of the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0058] Figure 1 A structure schematic diagram of the access peritoneal dialysis real-time dilution detection device according to the embodiments of the present application is shown. As shown in the figure, the access peritoneal dialysis real-time dilution detection device provided by the present application comprises a drainage unit, a dilution unit, a mixing unit, a detection unit and an abdominal pressure meter 24. Figure 1

[0059] The drainage unit is connected with the mixing unit and the abdominal pressure meter 24 through a catheter respectively.

[0060] The dilution unit and the mixing unit are connected through a catheter.

[0061] The mixing unit and the detection unit are connected through a catheter.

[0062] The drainage unit is used for placing a thin catheter 8 into the abdominal cavity of a patient in a sterile manner and continuously draining the dialysis fluid in the abdominal cavity.

[0063] The dilution unit is used for performing real-time proportional dilution on the drained dialysis fluid.

[0064] The mixing unit is used for uniformly mixing the diluted dialysis fluid and heating it to 37℃ to ensure the accuracy of detection.

[0065] The detection unit is used for detecting the glucose concentration of the diluted dialysis fluid in real time. In an alternative, the amount of dialysis fluid drained by the detection device is recorded during the infusion and drainage process.

[0066] The drainage unit comprises a sterile bag 5, a catheter placer 7, a thin catheter 8, a first outlet 10 and a second outlet 21.

[0067] The sterile bag 5 is provided with the first outlet 10 at one end and the second outlet 21 at the other end. The first outlet 10 is provided with a knob which can be used for the thin catheter 8 to pass out after being opened and will not cause leakage. The sterile bag 5 is closed except for the two openings.

[0068] The catheter placer 7 is fixedly installed at the second outlet 21 end of the sterile bag 5 and located in the sterile bag 5.

[0069] ​Two said inserted fine catheter 8 one end through the catheter 7;

[0070] One said inserted fine catheter 8 the other end through the first outlet 10 and the mixed unit peristaltic pump 11 connection, the other inserted fine catheter 8 the other end through the first outlet 10 and the abdominal pressure instrument 24 connection;

[0071] The abdominal pressure instrument 24 is used for real-time detection of abdominal pressure, and the detection unit is used for real-time detection of the glucose concentration in the solution after dilution by the mixed unit.

[0072] The sterile bag 5 is used for sterile wrapping the inserted fine catheter 8 and the catheter 7;

[0073] The catheter 7 is used for sterile insertion of the inserted fine catheter 8 into the abdominal cavity of the patient;

[0074] The inserted fine catheter 8 is used for insertion into the abdominal cavity of the patient, and the peritoneal dialysis fluid in the abdominal cavity is continuously introduced out;

[0075] The first outlet 10 is used for introducing the inserted fine catheter 8 from the first outlet 10 after the insertion of the inserted fine catheter 8, and is connected with the peristaltic pump 11;

[0076] The second outlet 21 is used for being connected with the Y-shaped connecting catheter 1, and the inserted fine catheter 8 is introduced into the abdominal cavity through the second outlet.

[0077] The sterile bag 5 is a transparent soft bag, and the material is preferably silicone.

[0078] The total flow range of the access type peritoneal dialysis real-time dilution detection device of the application (i.e. the total amount of liquid introduced by the inserted fine catheter 8 to the heating oscillator 14 and the dilution liquid catheter 13) is 15-60ml / min. The above-mentioned flow rate can meet the detection needs and will not waste liquid excessively.

[0079] The application is to realize real-time micro-flow, dilution and detection of the concentration of dialysis fluid in the process of dialysis using an automatic peritoneal dialysis machine 19, to achieve the detection range of commercially available glucose detectors, to realize real-time detection of the pressure in the abdominal cavity of the patient, and to transmit data to a specific terminal server 18 for recording and analysis, to achieve the purpose of constructing a mathematical model for prediction and intelligent prescription adjustment.

[0080] Preferably, the inserted fine catheter 8 is a sterilized silicone tube with an inner diameter of not more than 1mm.

[0081] The silicone tube has moderate hardness, is convenient to insert into the abdominal cavity, and will not cause damage to the patient; will not form creases after bending, and will not affect the drainage effect; is not prone to allergic reactions; has a small inner diameter, is easy to store and insert, and will not affect the normal liquid exchange between the automatic peritoneal dialysis machine 19 and the abdominal cavity of the patient; has a small inner diameter, and is more easily opened and closed by the buckle switch 6.

[0082] Alternatively, flexible hoses made of other materials that are bendable, have a certain degree of rigidity, but will not crease, with an inner diameter of no more than 1 mm, such as latex.

[0083] Preferably, the catheter inserter 7 is an automatic device, and the user controls the insertion and removal of the fine catheter 8 by using two buttons: in and out.

[0084] like Figure 2 As shown, specifically, the catheter inserter 7 includes a housing 71, a catheter insertion inlet 72, a catheter insertion outlet 73, a sensor 74, a roller conveyor belt 75, an adjustment length button 76, a display screen 77, an indicator light 78, a catheter insertion button 79, a catheter removal button 710, a catheter insertion channel 711, a motor, and a power supply.

[0085] The outer shell 71 is rectangular parallelepiped;

[0086] The catheter insertion inlet 72 and catheter insertion outlet 73 are respectively provided on the front and rear side walls of the outer shell 71, forming a catheter insertion channel 711 between them; the catheter insertion inlet 72 and catheter insertion outlet 73 are the same size and shape, and their shapes match the two parallel insertion thin catheters 8.

[0087] The sensor 74 is fixedly installed at the catheter insertion outlet 73;

[0088] The top and bottom of the conduit insertion channel 711 are respectively provided with roller conveyor belts 75; the roller conveyor belts 75 are fixedly installed on the outer shell 71.

[0089] The length adjustment button 76, display screen 77, indicator light 78, catheter insertion button 79, catheter removal button 710, and catheter insertion inlet 72 are all fixedly installed on the front side wall of the housing 71.

[0090] The roller conveyor belt 75 is electrically connected to the sensor 74, the conduit insertion button 79, and the conduit removal button 710, respectively.

[0091] The length adjustment button 76 is electrically connected to the sensor 74 and the display screen 77 respectively;

[0092] Sensor 74 is electrically connected to display screen 77 and indicator light 78 respectively.

[0093] Sensor 74 is used to detect the position and length of the inserted fine catheter 8;

[0094] The roller conveyor belt 75 is used to push the inserted fine guide tube 8 forward or backward;

[0095] Length adjustment button 76 is used to set the length of the catheter 8 to be inserted under the guidance of the medical staff to ensure the success of the insertion of the catheter 8;

[0096] Display screen 77 is used to display the set length of the catheter 8 to be inserted;

[0097] Indicator light 78 is used to indicate that the length of the catheter 8 to be inserted has reached the set value and the insertion is complete;

[0098] Catheter insertion button 79 is used to control the roller conveyor 75 to start the catheter insertion process. After the length of the catheter 8 to be inserted reaches the set value, the catheter insertion button 79 can also be double-clicked to manually insert the catheter 8;

[0099] Catheter removal button 710 is used to control the roller conveyor 75 to start the catheter removal process;

[0100] Catheter insertion channel 711 is used to allow the catheter 8 to be inserted through the catheter insertion device 7;

[0101] Motor, arranged in the housing 71, is used to drive the roller conveyor 75 to rotate;

[0102] Power supply, arranged in the housing 71, is used to power the catheter insertion device 7.

[0103] When the patient needs to insert a catheter for detection, one end of the catheter 8 to be inserted is inserted inward from the catheter insertion inlet 72 and is inserted inward through the roller conveyor 75. When the catheter 8 to be inserted passes through the catheter insertion outlet 73, it will be detected by the sensor 74, and the length of the catheter 8 to be inserted will be recorded.

[0104] According to the conditions of most patients, a certain length of insertion is set by adjusting the length adjustment button 76, and the set length is displayed on the display screen 77.

[0105] When the sensor 74 senses that the length of the insertion reaches the length set on the display screen 77, the indicator light 78 is on. If the patient has special conditions and the catheter 8 to be inserted is not inserted completely, the catheter insertion button 79 can be manually double-clicked to insert deeper and to the appropriate position. After the patient releases the catheter insertion button 79, the insertion is stopped.

[0106] When the patient finishes the detection and removes the catheter 8 to be inserted, the catheter removal button 710 is pressed, the roller conveyor 75 moves in the opposite direction, and the catheter 8 to be inserted is removed outward. When the sensor 74 senses that the catheter 8 to be inserted is completely removed, the indicator light 78 is turned off.

[0107] Alternatively, the catheter insertion device 7 uses a wheel shaft device, and the user controls the position of the catheter 8 to be inserted through the set knob;

[0108] Alternatively, the placement catheter 8 is placed manually by the operator by operating outside the sterile bag 5, and the placement catheter 8 is placed into the peritoneal dialysis catheter of the patient.

[0109] In some embodiments, the drainage unit further comprises a buckle 9.

[0110] The buckle 9 is arranged at the first outlet 10 end of the sterile bag 5, and the buckle 9 is fixedly installed in the sterile bag 5.

[0111] The buckle 9 is used to fix the position of the placement catheter 8.

[0112] Alternatively, the buckle 9 can not be arranged, and the placement catheter 8 is manually guided into the correct position.

[0113] In some embodiments, the access type peritoneal dialysis real-time dilution detection device further comprises a Y-shaped connecting catheter 1.

[0114] The Y-shaped connecting catheter 1 comprises a machine end connector 2, a patient end connector 3, and a catheter end connector 4.

[0115] The machine end connector 2 is connected to the automatic peritoneal dialysis machine 19 through a pipeline.

[0116] The patient end connector 3 is connected to the peritoneal dialysis catheter; wherein the peritoneal dialysis catheter is connected to the abdominal cavity of the patient.

[0117] The catheter end connector 4 is connected to the second outlet 21 of the sterile bag 5.

[0118] The inner diameter of the Y-shaped connecting catheter 1 is about 0.25-0.5cm, which is consistent with the inner diameter of the peritoneal dialysis catheter.

[0119] The Y-shaped connecting catheter 1 is used to connect the automatic peritoneal dialysis machine 19 and the peritoneal dialysis patient, and introduce the placement catheter 8 into the peritoneal dialysis catheter of the patient, so that the automatic continuous drainage is performed during the peritoneal dialysis of the patient.

[0120] Optionally, the access type peritoneal dialysis real-time dilution detection device further comprises a buckle switch 6 and a flow rate sensor 22.

[0121] The buckle switch 6 is arranged on the catheter end connector 4.

[0122] The flow rate sensor 22 is arranged on the machine end connector 2, and the flow rate sensor 22 is connected to the buckle switch 6 and the peristaltic pump 11 respectively (not shown in the figure). Figure 1

[0123] ​The buckle switch 6 is connected with the flow rate sensor 22. When the automatic peritoneal dialysis machine 19 exchanges liquid with the patient, the flow rate sensor 22 detects the liquid flow, and the buckle switch 6 is closed. When the liquid exchange ends and the patient enters the retention state, the flow rate sensor 22 does not detect the liquid flow, and the buckle switch 6 is opened. Whether to set the buckle switch 6 and the flow rate sensor 22 can be decided in subsequent research according to the research results or the needs of the patient.

[0124] By setting the Y-shaped connecting conduit 1, it can be applied to different brands of automatic peritoneal dialysis machines 19 to achieve the purpose of easier popularization and operation, and lower cost. For example, it can be applied to automatic peritoneal dialysis machines 19 of brands such as Becton, Dickenson and Jerry.

[0125] Alternatively, the buckle switch 6 is set as a manual switch for manual operation.

[0126] Alternatively, no switch is set, and the diameter of the Y-shaped connecting conduit 1 is reduced as much as possible to avoid affecting the liquid exchange process.

[0127] In some embodiments, the dilution unit comprises a water purifier 25, a dilution liquid bottle 12 and a dilution liquid conduit 13.

[0128] A plurality of the dilution liquid conduits 13 are connected with the dilution liquid bottle 12 at one end and connected with the peristaltic pump 11 of the mixing unit at the other end.

[0129] The water purifier 25 is connected with the dilution liquid bottle 12 at one end and connected with an external water supply at the other end.

[0130] The water purifier 25 is used to purify the external water supply to meet the requirements of the dilution liquid.

[0131] The dilution liquid bottle 12 is used to store the dilution liquid.

[0132] The dilution liquid conduit 13 is used to transport the dilution liquid.

[0133] The dilution unit can achieve at least five times of real-time dilution effect. By real-time dilution, the glucose concentration is reduced to the linear detection range of the commercially available glucose detector, without the need to develop and test a higher range glucose detector.

[0134] As shown in Figure 3 Alternatively, the dilution unit comprises a water purifier 25, a dilution liquid bottle 12, a dilution liquid conduit 13 and a conical container 20.

[0135] The conical container 20 is in the shape of an inverted cone, and a plurality of conduit interfaces are provided on the side wall at the same diameter, and an outlet is provided at the apex. The plurality of conduit interfaces are located at the same height and are arranged at equal intervals. For example, the conduit interfaces are provided with 5.

[0136] The water purifier 25 is connected with the diluent bottle 12.

[0137] The diluent bottle 12 is connected with the conduit interface of the side wall of the conical container 20 through the diluent conduit 13.

[0138] The implantation fine conduit 8 is connected with the conduit interface of the side wall of the conical container 20.

[0139] The outlet of the conical container 20 is connected with the single peristaltic pump 11; wherein the peristaltic pump 11 is a single-channel type.

[0140] The single peristaltic pump 11 is connected with the heating oscillator 14.

[0141] The length and inner diameter of each of the implantation fine conduits 8 are the same as those of the diluent conduit 13. The same length and inner diameter are to ensure that the drainage suction force of each conduit is the same, i.e. the drainage volume of each conduit is the same, so as to ensure that the dilution is performed in equal ratio.

[0142] For example, the conduit interface of the side wall of the conical container 20 is provided with 10 conduit interfaces, 9 of which are connected with the diluent conduit 13, and 1 of which is connected with the implantation fine conduit 8, so as to perform ten times of real-time equal-ratio dilution on the drained dialysate.

[0143] The conical container 20 is used for storing the diluent and the drained dialysate.

[0144] The conical container 20 can ensure that the distance of each conduit to the conical outlet (i.e. the connection position of the outlet conduit connected with the peristaltic pump 11) is completely equal, so as to ensure that the suction force of each conduit by the single peristaltic pump 11 is the same, i.e. the drainage volume of each conduit is the same, so as to ensure that the dilution is performed in equal ratio.

[0145] In some embodiments, the number of the diluent conduits 13 is not less than 4.

[0146] For example, as shown in Figure 1 the number of the diluent conduits 13 is set to 4, so as to perform five times of real-time equal-ratio dilution on the drained dialysate.

[0147] For example, when the glucose-based peritoneal dialysate with a mass percentage of 4.25% (i.e. 100 ml of dialysate contains 4.25 g of glucose) is used, and ten times of real-time equal-ratio dilution is required, the number of the diluent conduits 13 can be set to 9.

[0148] Although the number of the diluent conduits 13 is set to 4 in the above description, the present application is not limited thereto, and in the implementation and use, the number can be adjusted according to the concentration of the dialysate.

[0149] In some embodiments, the mixing unit comprises a peristaltic pump 11 and a heating shaker 14;

[0150] The peristaltic pump 11 is connected with the implanted thin catheter 8 and the dilution liquid catheter 13 respectively; wherein the peristaltic pump 11 is a multi-channel type;

[0151] The peristaltic pump 11 is connected with the heating shaker 14 through a pipeline.

[0152] The peristaltic pump 11 is used to provide power for continuously leading out the dialysis liquid in the abdominal cavity;

[0153] The heating shaker 14 is used to uniformly mix the diluted liquid and heat the temperature to body temperature (37℃).

[0154] The heating shaker 14 mixes the diluted liquid and the led-out dialysis liquid, ensures uniform mixing, and heats the mixed liquid to body temperature, so as to ensure that the detection value of the glucose detector is more accurate.

[0155] Alternatively, a plurality of high-precision micro-flow single-channel peristaltic pumps 11 are used, and at least five times of quantitative dilution can be performed. Figure 4 As shown, for example, four peristaltic pumps 11 are used to be connected with the dilution liquid bottles 12 through the dilution liquid catheters 13 respectively; and one peristaltic pump 11 is connected with the implanted thin catheter 8. The above peristaltic pumps 11 are connected with the heating shaker 14.

[0156] In some embodiments, the detection unit comprises a self-powered detection sensor module 15, a waste liquid tank 16 and an electronic scale 17;

[0157] The inlet of the self-powered detection sensor module 15 is connected with the outlet of the heating shaker 14 through a detection catheter 23, and the outlet of the self-powered detection sensor module 15 is connected with the waste liquid tank 16 through the detection catheter 23;

[0158] The self-powered detection sensor module 15 comprises a temperature sensor and a glucose detection sensor.

[0159] Wherein, the inner diameter of the detection catheter 23 ranges from 5mm to 10mm, which meets the implanted length required by the commercially available glucose detector; the self-powered detection sensor module 15 is positioned at a distance of 5-10cm behind the heating shaker 14, the fixed distance allows the delayed time of measurement to be estimated, the temperature sensor detects the temperature of the liquid to ensure that the heating reaches 37℃, and the accuracy of the glucose concentration detection is ensured, and the heat energy is used as the energy source to generate electric current, and the electric current is supplied to the glucose detection sensor.

[0160] The waste liquid tank 16 is arranged on the electronic scale 17;

[0161] If the latching switch 6 and flow sensor 22 are not installed, the self-generating detection sensor module 15, electronic scale 17, and abdominal pressure meter 24 are connected to the terminal server 18. This setup allows for continuous measurement during fluid exchange, resulting in more complete test data.

[0162] If the snap switch 6 and the flow sensor 22 are provided, the flow sensor 22 is connected to the snap switch 6 and the peristaltic pump 11 respectively. Figure 1 (Not shown in the image). The self-generating detection sensor module 15, electronic scale 17, and abdominal pressure meter 24 are connected to the terminal server 18. When the flow rate sensor 22 detects liquid flow, the latch switch 6 closes to prevent the access-type peritoneal dialysis real-time dilution detection device from affecting the liquid exchange of the automatic peritoneal dialysis machine 19, and the peristaltic pump 11 stops. The above settings prevent the liquid exchange process from affecting the detection data, which facilitates the modeling of the glucose concentration curve during the dialysis retention stage; liquid weighing can more accurately calculate the ultrafiltration volume during the retention process, and the test results of this scheme are more accurate.

[0163] The self-generating detection sensor module 15 is used to continuously detect the glucose concentration of the diluted peritoneal dialysis fluid and transmit the data to the terminal server 18.

[0164] Waste liquid tank 16 is used to collect and store the drained liquid;

[0165] Electronic scale 17 is used to weigh the drained liquid and to calibrate the ultrafiltration rate calculation, making the ultrafiltration rate calculation more accurate.

[0166] If a latching switch 6 is not installed between the Y-type connecting catheter 1 and the sterile bag 5, the data from the electronic scale 17 will be transmitted to the terminal server 18 at the beginning and end of each abdominal retention.

[0167] In some embodiments, the access-type peritoneal dialysis real-time dilution detection device further includes: a terminal server 18;

[0168] The terminal server 18 is connected to the self-generating detection sensor module 15, the abdominal pressure meter 24, the electronic scale 17, and the automatic peritoneal dialysis machine 19, respectively.

[0169] Terminal server 18 is used to store and integrate data, provide feedback to physicians, issue alarms when abnormal values ​​occur, and enable physicians to remotely adjust the automated peritoneal dialysis machine 19.

[0170] This invention configures a corresponding terminal server 18 to depict the concentration curve of substances in the peritoneal cavity of peritoneal dialysis patients in real time, and uses big data to build a model for prediction, providing feedback on a better peritoneal dialysis plan.

[0171] In some embodiments, the access peritoneal dialysis real-time dilution detection device further comprises: a housing 26, a battery 27, a power line 28 and a solar panel 29;

[0172] The battery 27 is arranged inside the housing 26;

[0173] The solar panel 29 is arranged on the top of the housing 26;

[0174] The power line 28 and the solar panel 29 are electrically connected with the battery 27 respectively;

[0175] The battery 27 is electrically connected with the self-power generation detection sensor module 15, the water purifier 25, the heating oscillator 14 and the peristaltic pump 11 (not shown in the figure).

[0176] The battery 27 is arranged in the present application, and the solar energy and the power grid are used for dual power supply, so that the electric power resource is saved.

[0177] The water purifier 25, the dilution liquid bottle 12, the dilution liquid conduit 13, the peristaltic pump 11, the heating oscillator 14 and the self-power generation detection sensor module 15 are fixedly arranged in the housing 26, and the multiple components are integrated in the housing 26, so that the use is facilitated.

[0178] The access peritoneal dialysis real-time dilution detection device of the present application is used for detecting different concentrations of commercially available peritoneal dialysis liquid, and the detection results are shown in Table 1 (the data in Table 1 is detected by the biochemical examination department of a hospital). From the results, it can be concluded that the calculation results after dilution are closer to the actual values, and the higher the concentration, the greater the error in detection, and a great value may appear undetectable. The excipient original liquid is a non-glucose-based peritoneal dialysis liquid, which proves that low-concentration glucose can be directly detected, but high-concentration cannot.

[0179] The working principle of the access peritoneal dialysis real-time dilution detection device of the present application is as follows:

[0180] First, the Y-shaped connecting conduit 1 is connected with the automatic peritoneal dialysis machine 19 conduit, the peritoneal dialysis conduit and the sterile bag 5 respectively, the peritoneal dialysis conduit switch is opened, the patient and the automatic peritoneal dialysis machine 19 are communicated, the peritoneal dialysis is started, then the two insertion fine conduits 8 are inserted into the abdominal cavity of the patient through the peritoneal dialysis conduit by the conduit insertion device 7, after insertion, the first outlet 10 of the sterile bag 5 is opened, the other end of the two insertion fine conduits 8 is penetrated out of the sterile bag 5, one end is connected with the peristaltic pump 11, and the other end is connected with the abdominal pressure instrument 24, the abdominal pressure instrument 24 transmits data to the terminal server 18 in real time.

[0181] Use multi-channel high-precision micro flow peristaltic pump 11, one channel is connected with the placement of thin catheter 8, another channel through the diluent conduit 13 and diluent bottle 12 is connected, need at least can carry out five times of quantitative dilution, in the heating oscillator 14 place mixing and carry out electric heating, make liquid reach 37℃, on the outlet pipeline set up spontaneous electricity detection sensor module 15, the outlet pipeline end is introduced into the waste liquid cylinder 16, waste liquid cylinder 16 is set below electronic scale 17;Spontaneous electricity detection sensor module 15 real-time data transmission to terminal server 18, electronic scale 17 data at the beginning and end of each time to stay abdomen respectively data transmission to terminal server 18.

[0182] Although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that the technical solutions recorded in the foregoing embodiments can still be modified, or some technical features can be replaced by equivalents; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. An access-type peritoneal dialysis real-time dilution detection device, characterized in that, include: Drainage unit, dilution unit, mixing unit, detection unit and abdominal pressure meter (24); The dilution unit and the mixing unit are connected by conduits; The mixing unit and the detection unit are connected by a conduit; The drainage unit includes a sterile bag (5), a catheter inserter (7), a fine catheter (8), and a buckle (9); The sterile bag (5) has a first outlet (10) at one end and a second outlet (21) at the other end. The buckle (9) is located at the first outlet (10) end of the sterile bag (5) and is fixedly installed inside the sterile bag (5); The catheter inserter (7) is located at the second outlet (21) end of the sterile bag (5) and is fixedly installed inside the sterile bag (5); One end of each of the two insertion fine catheters (8) passes through the catheter inserter (7); One of the inserted fine catheters (8) passes through the first outlet (10) and is connected to the mixing unit, and the other of the inserted fine catheters (8) passes through the first outlet (10) and is connected to the abdominal pressure meter (24); The abdominal pressure meter (24) is used to detect abdominal pressure in real time, and the detection unit is used to detect the glucose concentration in the solution after dilution by the mixing unit in real time. Also includes: Y-type connecting catheter (1); The Y-type connecting catheter (1) includes a machine end connector (2), a patient end connector (3), and a catheter end connector (4). The machine end connector (2) is connected to the automated peritoneal dialysis machine (19); The patient end connector (3) is connected to the peritoneal dialysis catheter; The catheter end connector (4) is connected to the second outlet (21) of the sterile bag (5).

2. The access-type peritoneal dialysis real-time dilution detection device according to claim 1, characterized in that, The catheter inserter (7) includes a housing (71), a catheter insertion inlet (72), a catheter insertion outlet (73), a sensor (74), a roller conveyor belt (75), an adjustment length button (76), a display screen (77), an indicator light (78), a catheter insertion button (79), a catheter removal button (710), and a catheter insertion channel (711). The outer shell (71) is rectangular; The catheter insertion inlet (72) and catheter insertion outlet (73) are respectively provided on the two corresponding side walls of the outer shell (71), forming a catheter insertion channel (711) between them. The sensor (74) is located at the catheter insertion outlet (73); Roller conveyor belts (75) are respectively provided on both sides of the catheter insertion channel (711); The length adjustment button (76), display screen (77), indicator light (78), catheter insertion button (79), catheter removal button (710) and catheter insertion inlet (72) are all located on the same side wall of the outer casing (71).

3. The access-type peritoneal dialysis real-time dilution detection device according to claim 1, characterized in that, The dilution unit includes: a diluent bottle (12), a diluent conduit (13), and a water purifier (25). One end of the diluent conduit (13) is connected to the diluent bottle (12), and the other end is connected to the mixing unit; One end of the water purifier (25) is connected to the diluent bottle (12).

4. The access-type peritoneal dialysis real-time dilution detection device according to claim 3, characterized in that, The number of diluent conduits (13) shall not be less than 4.

5. The access-type peritoneal dialysis real-time dilution detection device according to claim 1, characterized in that, The inserted fine catheter (8) is a silicone tube with an inner diameter of no more than 1 mm.

6. The access-type peritoneal dialysis real-time dilution detection device according to claim 1, characterized in that, The mixing unit includes a peristaltic pump (11) and a heated oscillator (14). The peristaltic pump (11) is connected to the inserted thin tubing (8) and the dilution unit, respectively; The peristaltic pump (11) is connected to the heating oscillator (14).

7. The access-type peritoneal dialysis real-time dilution detection device according to claim 1, characterized in that, The detection unit includes a self-generating detection sensor module (15), a waste liquid tank (16), and an electronic scale (17). The inlet of the self-generating power detection sensor module (15) is connected to the mixing unit, and the outlet is connected to the waste liquid cylinder (16); The waste liquid tank (16) is mounted on the electronic scale (17).

8. The access-type peritoneal dialysis real-time dilution detection device according to claim 7, characterized in that, Also includes: Terminal server (18); The terminal server (18) is connected to the self-generating detection sensor module (15), the abdominal pressure meter (24), the electronic scale (17), and the automatic peritoneal dialysis machine (19), respectively.

9. The access-type peritoneal dialysis real-time dilution detection device according to claim 1, characterized in that, The dilution unit includes: a water purifier (25), a diluent bottle (12), a diluent conduit (13), and a conical container (20). The conical container (20) is conical in shape, with multiple conduit ports on its side walls and an outlet at its apex; wherein the multiple conduit ports are located at the same height and are equally spaced. The water purifier (25) is connected to the diluent bottle (12); The diluent bottle (12) is connected to the conical container (20) via a diluent conduit (13) and a conduit interface on the side wall of the conical container (20); The inserted fine catheter (8) is connected to the catheter interface on the side wall of the conical container (20); The outlet of the conical container (20) is connected to the mixing unit.

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