A sanitary insecticide composition and its application

Abstract

The present application relates to the field of sanitary insecticide technology, and specifically to a sanitary insecticide composition and its application. The sanitary insecticide composition described in the present application comprises active ingredient A and active ingredient B, active ingredient A is Es-biothrin, and active ingredient B is selected from one of cycloheximide and pyrethroid. The mass ratio of active ingredient A and active ingredient B in the composition is 1:20 to 2:1, and the total weight of active ingredients A and B accounts for 1% to 40% of the composition. The sanitary insecticide composition described in the present application has excellent control effects on sensitive and resistant mosquitoes and flies, and is particularly beneficial for controlling pyrethroid-resistant mosquitoes and flies; and has significant synergistic effects, can reduce the amount of insecticide used, and delay resistance.

Description

Technical Field

[0001] The present application relates to the field of sanitary insecticide technology, and more specifically to a sanitary insecticide composition and its application. More specifically, it relates to a sanitary insecticide composition of Es-bioallethrin, cycloheximidine, and pyrimethrin and its application. Background Art

[0002] Many common pests, such as mosquitoes, flies, cockroaches, bedbugs, lice, fleas, ticks, mites, midges, and blackflies, are vectors and can spread diseases. Mosquitoes, for example, can transmit malaria, dengue fever, epidemic encephalitis B, and lymphatic filariasis, while flies can spread a variety of diseases by mechanically carrying pathogens such as dysentery, typhoid, cholera, hepatitis, polio, and anthrax.

[0003] When a vector-borne disease breaks out, the most important thing is to quickly knock down and kill the vectors and cut off the chain of transmission. Currently, the main method used is to use a combination of knockdown agents and lethal agents as sanitary insecticides, using sprays, ultra-low volume sprays, and / or thermal fog sprays to quickly knock down and kill mosquitoes, flies, and other vector insects. Knockdown agents generally use pyrethroid insecticides with good knockdown effects, such as transfluthrin, Es-bioallethrin, tetrafluthrin, chlorfluthrin, d-trans-chlorpropylthrin, tetrafluthrin, and tetramethrin. Lethal agents generally use insecticides with good lethal effects, mainly pyrethroid insecticides such as permethrin, beta-cypermethrin, and deltamethrin, and carbamates such as propoxur may also be used.

[0004] Currently, there are two types of public health insecticides: pyrethroid knockdown agents + pyrethroid lethal agents, and pyrethroid knockdown agents + propoxur lethal agents. Although there are numerous products, the types of agents are very limited, and there is a lack of rotational agents. Furthermore, due to the long-term and extensive use of pyrethroids, mosquitoes have developed varying degrees of resistance to them, making pyrethroid insecticides increasingly ineffective. There is an urgent need for insecticides with different mechanisms of action to manage pyrethroid resistance and to implement rotational agents.

[0005] Cyclodextrin is a cis-nitro-oxygen-bridged heterocyclic neonicotinoid insecticide independently developed by East China University of Science and Technology. It is an antagonist of the nicotinic acetylcholine receptor. Bifenthrin is a new, highly effective, low-toxic, broad-spectrum neonicotinoid insecticide jointly developed by Shanghai East China University of Science and Technology and Jiangsu Kesheng Group Co., Ltd.

[0006] There are no reports in the prior art of combining the knockdown agent Es-bioallethrin with the lethal agents cycloxanthrin or pyrimethrin. Through extensive testing, the applicants have discovered that this combination has excellent control effects against pests, particularly mosquitoes and flies, and is particularly beneficial for combating pyrethroid-resistant mosquitoes and flies. Furthermore, it exhibits significant synergistic effects, reducing insecticide usage and delaying resistance development. Summary of the Invention

[0007] The purpose of the present invention is to overcome the problems existing in the prior art and provide a sanitary insecticide composition containing a pyrethroid knockdown agent and cycloheximidine and pyrethroid, and its application, which has excellent control effects on sanitary pests, especially mosquitoes and flies, and is particularly beneficial for controlling pyrethroid-resistant mosquitoes and flies; and has a significant synergistic effect, can reduce the amount of insecticide used and delay resistance.

[0008] The present application provides a sanitary insecticide composition, comprising an active ingredient A and an active ingredient B, wherein the active ingredient A is Es-bioallethrin, and the active ingredient B is selected from one of cycloheximidine and pyrimethrin.

[0009] The combination of active ingredient A and active ingredient B achieved an unexpected synergistic effect.

[0010] In the sanitary insecticide composition, the weight ratio of the active ingredient A to the active ingredient B is 1:20 to 2:1; preferably, the weight ratio of the two is 1:20 to 1:1; more preferably, the weight ratio of the two is 1:15 to 1:1, 1:10 to 1:1; most preferably, the weight ratio of the two is 1:5 to 1:1.

[0011] In the sanitary insecticide composition, the weight ratio of the Es-bioallethrin to cycloheximidine is 1:5 to 1:2; or the weight ratio of the Es-bioallethrin to cycloheximidine is 1:2 to 1:1.

[0012] In the sanitary insecticide composition, the sum of the contents of active ingredient A and active ingredient B in the composition is 1% to 40% of the total weight of the composition, preferably 2% to 30%, 2% to 25%, 3% to 20%, 3% to 15%, 4% to 10%, or 5% to 10%.

[0013] The sanitary insecticide composition described herein can be prepared into a dosage form permitted for sanitary insecticides. For example, it can be prepared into a dosage form permitted for sanitary insecticides with pesticide adjuvants. The dosage form is a suspension concentrate, wettable powder, emulsifiable concentrate, microemulsion, soluble concentrate, emulsion in water, water-dispersible granules, or suspoemulsion; preferably, the dosage form is a microcapsule suspension concentrate, dispersible oil suspension concentrate, wettable powder, emulsifiable concentrate, microemulsion, emulsion in water, or ultra-low volume liquid.

[0014] The auxiliary components of the pesticide preparation include carriers and adjuvants.

[0015] Furthermore, the carrier is any one, two or three of water, solvent or filler.

[0016] Furthermore, the solvent includes but is not limited to one or more of C6-C30 isoparaffin or dearomatized solvent oil, methyl laurate, diethyl maleate, tributyl phosphate and other low-toxic and odorless monoester, diester or triester solvents, diisooctyl phthalate, trans-2-hexenol, diesel, diisopropyl diacid, dimethyl phthalate, vegetable oil, engine oil and dimethyl sulfoxide.

[0017] Furthermore, the filler includes but is not limited to one or more of kaolin, white carbon black, clay, bentonite, attapulgite, diatomaceous earth and light calcium.

[0018] Furthermore, the auxiliary agents can be divided into wetting agents, dispersants, emulsifiers, disintegrants, antifreeze agents, preservatives, defoaming agents, thickeners, acid-base regulators, binders, etc. According to different requirements, the above auxiliary agents are selectively added.

[0019] Furthermore, the wetting agent includes but is not limited to one or more of fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, alkyl sulfate, naphthalene sulfonate, alkyl succinate sulfonate and alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate.

[0020] Furthermore, the dispersant includes but is not limited to one or more of polyether phosphates and salts thereof, alkylphenol polyoxyethylene ether formaldehyde condensate sulfonates, polycarboxylates, block polyethers, phenylethylphenol polyoxyethylene ether phosphate triethanolamine salts, naphthalenesulfonate formaldehyde condensates, lignin sulfonates, pull-open powder, NNO, MF and IS dispersing.

[0021] Furthermore, the emulsifier includes but is not limited to one or more of polyether phosphate or salt, T-60, calcium dodecylbenzene sulfonate, ethylene oxide propylene oxide block copolymer, fatty alcohol polyoxyethylene ether, castor oil polyoxyethylene ether, alkylphenol polyoxyethylene ether, alkylbenzene sulfonate calcium and block polyether.

[0022] Furthermore, the disintegrant includes but is not limited to one or more of ammonium sulfate, sodium sulfate, glucose, corn starch, ammonium chloride, bentonite, urea and sodium bicarbonate.

[0023] Furthermore, the antifreeze agent includes but is not limited to one or more of ethylene glycol, propylene glycol, glycerin, sodium chloride, urea, cellosolve, sorbitol, polyvinyl pyrrolidone and calcium chloride.

[0024] Furthermore, the preservative includes but is not limited to one or more of sodium benzoate, potassium sorbate, sodium dehydroacetate, sodium diacetate, kasone, paraben or its sodium salt, bronopol, pentanediol and sodium salicylate.

[0025] Furthermore, the defoaming agent includes but is not limited to one or more of organosilicon compounds, lower alcohols, silicone oils, phosphates, fatty acids, and fatty acid esters.

[0026] Furthermore, the thickener includes but is not limited to one or more of xanthan gum, fumed SiO2, bentonite, aluminum stearate, dragon gum powder, polyvinyl alcohol, modified cellulose, magnesium aluminum silicate, gum arabic, gum, gelatin, guar gum, alginic acid, agar and tall oil.

[0027] Furthermore, the acid-base regulator includes but is not limited to one or more of citric acid, oxalic acid, ammonium chloride, tartaric acid and succinic acid.

[0028] Furthermore, the binder includes but is not limited to one or more of polyvinyl pyrrolidone, sodium carboxymethyl cellulose, methyl cellulose, polyvinyl alcohol, dextrin, sodium alginate, sodium alginate, calcium lignosulfonate, etc.

[0029] The present application also provides the use of the sanitary insecticide composition for controlling sanitary pests. The sanitary pests are mosquitoes, flies, cockroaches, bedbugs, lice, fleas, ticks, mites, midges, gnats, horseflies, sandflies, and cockroaches; the sanitary pests are preferably mosquitoes and flies.

[0030] Furthermore, the sanitary mosquitoes include but are not limited to Culex pipiens pallens, Culex pipiens quinquefasciatus, Aedes albopictus, Aedes aegypti, Aedes aegypti, Culex pipiens harassing, Culex pipiens acuminata, Culex pipiens minutus, Culex tritaeniorhynchus, Anopheles gambiae, Anopheles arabiensis, Anopheles melanogaster, Anopheles minimus, Anopheles diversi, Anopheles stephensi, Anopheles sinensis, and Anopheles anthropophagus.

[0031] Furthermore, the sanitary flies include but are not limited to house flies, stable flies, silk fly, bright green fly, big-headed rope, brown-tailed rope, copper green fly, summer toilet fly, and Yuan toilet fly.

[0032] The sanitary insecticide composition described in the present application is sprayed in space to control sanitary pests; the sanitary insecticide composition is diluted with water / kerosene at an appropriate multiple, and during the peak activity period of disease-carrying insects (mosquitoes and flies), it is sprayed using an ultra-low volume sprayer or a thermal fogger to quickly knock down and kill the disease-carrying insects, thereby cutting off the spread and transmission of the disease as soon as possible.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] (1) Cyclomethicone is an antagonist of nicotinic acetylcholine receptors, and pyrethroid is an agonist of nicotinic acetylcholine receptors. Different from pyrethroids and carbamates, it is used as a lethal agent in combination with pyrethroid knockdown agents, showing high efficiency in insecticide knockdown and lethality. It has excellent effects on sanitary pests, especially mosquitoes and flies, and is particularly beneficial for the control of pyrethroid-resistant mosquitoes and flies.

[0035] (2) The sanitary insecticide composition of the present application exhibits an unexpected synergistic effect, reduces the dosage of insecticides, delays the resistance of sanitary pests, and reduces the environmental load.

[0036] (3) The sanitary insecticide composition of the present invention is low-toxic, highly effective, and environmentally friendly, and is suitable for use in the prevention and control of pests in the sanitary field. It can be used as a rotation agent to control pyrethroid-resistant mosquitoes and flies, and adds a new type of compound composition for the rapid control of vector-borne diseases (such as dengue fever, etc.), which delays the development of pest resistance and is beneficial to the control of pest resistance. DETAILED DESCRIPTION

[0037] The present invention will be further described below with reference to specific embodiments, but the present invention is not limited to these specific embodiments. Those skilled in the art should recognize that the present invention covers all possible alternatives, improvements and equivalents within the scope of the claims.

[0038] Application Example 1: Biological activity determination test of indoor sensitive strain of Culex pipiens pallens

[0039] Refer to "Guidelines for Indoor Bioassay Tests of Pesticides - Insecticides Part 1: Contact Activity Test Spot Method" NY / T1154.1-2006.

[0040] Test subjects: Culex pipiens pallens, indoor sensitive strain, female mosquitoes that did not feed on blood 3-5 days after emergence.

[0041] Test agents: Es-bioallethrin, cycloheximidine and pyrimethrin technical materials were weighed separately, dissolved in appropriate amount of acetone, and diluted to a series of concentrations.

[0042] Experimental treatment: The test adopted the drip method. After the drip treatment, standard feeding was resumed. Each group had 20 female mosquitoes, and the test was repeated 3 times. The number of deaths was counted after 24 hours.

[0043] Table 1 Results of biological activity determination by Culex pipiens spot method

[0044]

[0045]

[0046] Note: ng / ♀ represents the amount of drug instilled per female mosquito.

[0047] The co-toxicity coefficient (CTC value) of the mixture was calculated using the Sun Yunpei method.

[0048] The percentage of agent A in the mixture = agent A content / (agent A content + agent B content)×100%.

[0049] Actual toxicity index (ATI) of mixture = LC of agent A50 LC of mixture 50 ×100.

[0050] Theoretical toxicity index (TTI) of the mixture = ATI (A) × the percentage of agent A in the mixture + ATI (B) × the percentage of agent B in the mixture.

[0051] Co-toxicity coefficient (CTC) = actual toxicity index (ATI) of the mixture / theoretical toxicity index (TTI) of the mixture × 100.

[0052] A co-toxicity coefficient ≥120 indicates a synergistic effect; a co-toxicity coefficient ≤80 indicates an antagonistic effect; and a co-toxicity coefficient between 80 and 120 indicates an additive effect.

[0053] Table 2 Results of the co-toxicity coefficient determination of Es-bioallethrin and cycloheximide

[0054]

[0055]

[0056] Note: ng / ♀ represents the amount of drug instilled per female mosquito.

[0057] According to the results in Table 2, the weight ratio of Es-bioallethrin to cycloheximidine is 1:20 to 2:1, with a co-toxicity coefficient greater than 150, indicating a significant synergistic effect. In particular, the synergistic effect is even more pronounced when the ratio of Es-bioallethrin to cycloheximidine is 1:5 to 1:2, with values ​​exceeding 220.

[0058] Table 3 Determination results of the co-toxicity coefficient of Es-bioallethrin and pyrimethrin

[0059]

[0060] Note: ng / ♀ represents the amount of drug instilled per female mosquito.

[0061] According to the results in Table 3, the co-toxicity coefficient of Es-bioallethrin to pyrimethrin in a weight ratio of 1:20 to 2:1 was greater than 135, indicating a significant synergistic effect. In particular, the synergistic effect was even more pronounced when the ratio of Es-bioallethrin to pyrimethrin was 1:2 to 1:1, with values ​​exceeding 190.

[0062] Formulation Example 1: 10% cycloheximide.Es-bioallethrin emulsifiable concentrate (2:1)

[0063] 6.67 g of cycloheximide technical, 3.33 g of Es-bioallethrin technical, 2.0 g of calcium alkylbenzenesulfonate, 4.0 g of benzyl dimethylphenol polyoxyethyl ether, 3.0 g of phenylphenol polyoxyethyl ether phosphate, 8.0 g of dimethylformamide, and dodecylbenzene were added to make up to 100.0 g to prepare emulsifiable concentrate formulation Example 1.

[0064] Formulation Example 2: 10% cycloheximide.Es-bioallethrin suspension (5:1)

[0065] 8.33 g of cycloheximide technical drug and 1.67 g of Es-bioallethrin technical drug were adsorbed with 3.0 g of white carbon black, and the mixture was supplemented with water to 100.0 g, 1.0 g of fatty alcohol polyoxyethylene ether, 2.0 g of polycarboxylate, 2.0 g of block polyether emulsifier, 0.3 g of xanthan gum, and 5.0 g of ethylene glycol, and the mixture was mixed and ground to prepare suspension formulation Example 2.

[0066] Formulation Example 3: 10% pyrimethrin.Es-bioallethrin wettable powder (1:1)

[0067] 5 g of pyrimethrin technical, 5 g of Es-bioallethrin technical, 3.0 g of white carbon black, 3.0 g of sodium lauryl sulfate, 7.0 g of sodium lignin sulfonate, 0.3 g of citric acid, and kaolin were added to make up to 100.0 g to prepare wettable powder formulation Example 3.

[0068] Formulation Example 4: 10% Bifenthrin.Es-Biopithrin Microemulsion (2:1)

[0069] Microemulsion Preparation Example 4 was prepared by adding 6.67 g of benzopyrid technical drug, 3.33 g of Es-bioallethrin technical drug, 2.0 g of fatty alcohol polyoxyethylene ether, 17.0 g of castor oil polyoxyethylene ether, and dimethylformamide to make up to 100.0 g.

[0070] Comparative Example 1: 10% cycloheximide suspension

[0071] 10.0 g of cycloheximide technical was adsorbed with 3.0 g of white carbon black, 1.0 g of fatty alcohol polyoxyethylene ether, 2.0 g of polycarboxylate, 2.0 g of block polyether emulsifier, 0.3 g of xanthan gum, 5.0 g of ethylene glycol, and water was added to 100.0 g, and the mixture was mixed and ground to prepare a suspension concentrate according to Comparative Example 1.

[0072] Comparative Example 2: 10% Bifenthrin Suspension

[0073] 10.0 g of bispyribac original drug was adsorbed with 3.0 g of white carbon black, 1.0 g of fatty alcohol polyoxyethylene ether, 2.0 g of polycarboxylate, 2.0 g of block polyether emulsifier, 0.3 g of xanthan gum, 5.0 g of ethylene glycol, and water was added to 100.0 g, and the mixture was mixed and ground to prepare the suspension concentrate of Comparative Example 2.

[0074] Comparative Example 3: 10% Permethrin EC

[0075] Comparative Example 3 of emulsifiable concentrate preparation was prepared by adding 10 g of permethrin technical, 4 g of calcium dodecylbenzenesulfonate, 6 g of fatty alcohol polyoxyethylene ether, and 150# solvent oil to make up to 100 g.

[0076] Comparative Example 4: 10% Permethrin.Es-Biopthrin emulsifiable concentrate (2:1)

[0077] Comparative Example 4 of emulsifiable concentrate preparation was prepared by adding 6.67 g of permethrin technical, 3.33 g of Es-bioallethrin technical, 4 g of calcium dodecylbenzenesulfonate, 6 g of fatty alcohol polyoxyethylene ether, and 150# solvent oil to make up to 100 g.

[0078] Application Example 2: Indoor efficacy test on mosquitoes and flies

[0079] Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, spray method.

[0080] Test subjects: Culex pipiens pallens, indoor sensitive strain; Housefly, indoor sensitive strain.

[0081] Test treatment: mosquito and fly test preparation dosage 30mg / m 3 , diluted 50 times with water, sprayed in a cylinder, 30 heads per group, repeated 3 times, counted the number of knockdowns within 20 minutes, the test insects were restored to standard feeding, and the number of deaths was counted after 24 hours.

[0082] Table 4 Example preparation mosquito and fly indoor efficacy test results

[0083]

[0084] According to the results in Table 4, the lethal agents cycloheximide, cypermethrin and permethrin have very poor knockdown activity against mosquitoes and flies. After being combined with the knockdown agent, the knockdown activity of the combined preparations against mosquitoes and flies is significantly improved, and the mortality rate is also improved relative to the lethal single agent.

[0085] Application Example 3: Biological Activity Determination Test of Aedes albopictus Outdoor Strain

[0086] Refer to "Guidelines for Indoor Bioassay Tests of Pesticides - Insecticides Part 1: Contact Activity Test Spot Method" NY / T1154.1-2006.

[0087] Test subjects: female Aedes albopictus mosquitoes of sensitive and outdoor strains that have not fed blood on the 3rd to 5th day after emergence.

[0088] Test agents: Es-biopermethrin, permethrin, cycloheximidine and pyrimethrin technical drugs, add appropriate amount of acetone to dissolve and dilute to a series of concentrations.

[0089] Experimental treatment: The test adopted the drip method. After the drip treatment, standard feeding was resumed. Each group had 20 female mosquitoes, and the test was repeated 3 times. The number of deaths was counted after 24 hours.

[0090] Table 5 Aedes albopictus spot test results

[0091]

[0092] According to the results in Table 5, it can be seen that the Aedes albopictus collected outdoors developed resistance to permethrin with a resistance multiple of 7.25 times, while there was no significant difference in the activity of cycloheximide and pyrimethoxam against permethrin-resistant and sensitive strains. Therefore, cycloheximide and pyrimethoxam have no cross-resistance with permethrin and can control permethrin-resistant mosquitoes.

[0093] Application Example 4: Aedes albopictus efficacy test

[0094] Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, spray method.

[0095] Test subjects: outdoor Aedes albopictus strains collected, which were tested for biological activity according to Example 3 and showed a 7.25-fold resistance to permethrin, and were female mosquitoes that had not fed blood on the 3rd to 5th day after emergence.

[0096] Test treatment: Test preparation dosage 30mg / m 3 , diluted 50 times with water, sprayed in a cylinder, 30 heads per group, repeated 3 times, counted the number of knockdowns within 20 minutes, the test insects were restored to standard feeding, and the number of deaths was counted after 24 hours.

[0097] Table 6 Example preparations Aedes albopictus outdoor strain efficacy test results

[0098]

[0099]

[0100] According to the results in Table 6, it can be seen that the combination of cycloheximide / piperidin and Es-bioallethrin can control permethrin-resistant mosquitoes, and the knockdown speed and 24-hour mortality rate are significantly better than those of the combination of permethrin and Es-bioallethrin.

[0101] The sanitary composition of the present invention can be used as a rotation agent for permethrin compound preparations to control pyrethroid-resistant vector insects, providing a new type of agent for rapid control of vector-borne diseases (such as dengue fever, etc.), and has a synergistic effect, reducing the dosage of insecticides, delaying the resistance of sanitary pests, and reducing the environmental load.

[0102] The sanitary insecticide composition containing Es-bioallethrin and cycloheximide / piperidin and its application of the present invention have been described through specific examples. Those skilled in the art can refer to the content of the present invention and appropriately change the raw materials, process conditions and other links to achieve corresponding other purposes. The relevant changes do not depart from the content of the present invention. All similar replacements and modifications are obvious to those skilled in the art and are considered to be included in the scope of the present invention.

[0103] In the description of this specification, the descriptions with reference to the terms "one specific embodiment", "some embodiments", "example", "specific example", etc. mean that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in this specification and the features of different embodiments or examples without contradiction.

[0104] The scope of protection of this application is not limited to the above-described embodiments. Obviously, those skilled in the art may make various modifications and variations to this application without departing from the scope and spirit of the invention. If such modifications and variations fall within the scope of the claims of this application and their equivalents, the intention of this application also includes such modifications and variations.

Claims

1. A sanitary insecticide composition, characterized in that: The invention comprises active ingredient A and active ingredient B, wherein active ingredient A is Es-bioallethrin, and active ingredient B is selected from one of cycloheximidine and pyraclostrobin; and the weight ratio of the active ingredient A to the active ingredient B is 1:20 to 2:

1.

2. The sanitary insecticidal composition according to claim 1, wherein The weight ratio of the active ingredient A to the active ingredient B is 1:20 to 1:

1.

3. The sanitary insecticide composition according to claim 2, characterized in that The weight ratio of the active ingredient A to the active ingredient B is 1:10 to 1:

1.

4. The sanitary insecticide composition according to claim 3, characterized in that The weight ratio of the active ingredient A to the active ingredient B is 1:5 to 1:

1.

5. The sanitary insecticide composition according to claim 4, characterized in that The weight ratio of the Es-bioallethrin to cycloheximidine is 1:5 to 1:2; or the weight ratio of the Es-bioallethrin to cycloheximidine is 1:2 to 1:

1.

6. The sanitary insecticide composition according to any one of claims 1 to 5, characterized in that The total content of active ingredient A and active ingredient B in the composition is 1% to 40% of the total weight of the composition.

7. The sanitary insecticide composition according to claim 6, characterized in that The total content of active ingredient A and active ingredient B in the composition is 3% to 15% of the total weight of the composition.

8. The sanitary insecticide composition according to any one of claims 1 to 5, characterized in that The composition is prepared into a dosage form allowed by sanitary insecticides.

9. The sanitary insecticide composition according to claim 8, characterized in that The dosage forms include suspension, wettable powder, emulsifiable concentrate, microemulsion, soluble solution, aqueous emulsion, water-dispersible granules and suspoemulsion.

10. The sanitary insecticide composition according to claim 8, characterized in that The dosage form is microcapsule suspension, dispersible oil suspension, and ultra-low volume liquid.

11. The use of the sanitary insecticide composition according to any one of claims 1 to 10, characterized in that: Used for preventing and controlling sanitary pests; the sanitary pests are mosquitoes.

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