A pharmaceutical composition for burns and a method for preparing the same

Abstract

This invention provides a burn medication composition and its preparation method, belonging to the field of traditional Chinese medicine preparation technology. The medication composition includes a powder and an ointment. The powder comprises the following components in parts by weight: 6-9 parts of puffball powder, 6-9 parts of cattail pollen charcoal powder, 1-2 parts of peony bark powder, 3-5 parts of peppermint powder, and 3-5 parts of saposhnikovia root powder. The ointment comprises the following components in parts by weight: 6-12 parts of gromwell root, 5-9 parts of coptis root, 5-9 parts of scutellaria root, and 5 parts of astragalus root. -9 parts, Phellodendron bark 5-9 parts, Gardenia fruit 5-9 parts, Sophora flavescens 5-9 parts, Ligusticum chuanxiong 5-9 parts, Zanthoxylum bungeanum 5-9 parts, Salvia miltiorrhiza 5-9 parts, Angelica sinensis 5-9 parts, Ginseng 5-9 parts, American ginseng 5-9 parts, Artemisia capillaris 5-9 parts, Artemisia argyi 5-9 parts, Indigo naturalis 5-9 parts, Pearl powder 2-5 parts, Borneol 2-5 parts, Rosin 5-9 parts, Beeswax 150-200 parts, High-proof liquor 20-50 parts, and Vegetable oil 900-1200 parts. This invention is effective and has significant therapeutic effects on burn wounds.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine preparation technology, specifically relating to a burn drug composition and its preparation method. Background Technology

[0002] Burns and scalds are common accidental injuries in daily life, often caused by boiling water, boiling oil, fire, acids, or alkalis acting on the skin, resulting in complex skin conditions. First-degree burns only affect the epidermis, causing redness and swelling, but no blisters. Second-degree burns affect the dermis, causing localized redness, swelling, heat, pain, and prominent blisters. Third-degree burns are severe, damaging muscle tissue, bones, and nerve cells, causing charred and necrotic skin, and producing intense pain. If burns are not treated promptly, they can lead to infection, scarring, and impaired limb function.

[0003] Currently, most pain-relieving drugs for burns and trauma contain toxic, narcotic, and corrosive ingredients, and ointment bases often contain chemical bases and preservatives. Furthermore, they are slow to take effect, and the final therapeutic efficacy needs further improvement. Summary of the Invention

[0004] To address the problems existing in the background art, the present invention provides a burn drug composition and its preparation method, which contains herbal plant ingredients, has no toxic side effects, and is effective and has significant therapeutic effects on burn wounds.

[0005] To achieve the above objectives, in a first aspect, the present invention provides a burn pharmaceutical composition comprising a powder and an ointment;

[0006] The medicinal powder comprises the following components in parts by weight: 6-9 parts of puffball powder, 6-9 parts of cattail pollen charcoal powder, 1-2 parts of peony bark powder, 3-5 parts of peppermint powder, and 3-5 parts of saposhnikovia powder.

[0007] The ointment comprises the following components in parts by weight: 6-12 parts of Lithospermum erythrorhizon, 5-9 parts of Coptis chinensis, 5-9 parts of Scutellaria baicalensis, 5-9 parts of Astragalus membranaceus, 5-9 parts of Phellodendron chinense, 5-9 parts of Gardenia jasminoides, 5-9 parts of Sophora flavescens, 5-9 parts of Ligusticum chuanxiong, 5-9 parts of Zanthoxylum bungeanum, 5-9 parts of Salvia miltiorrhiza, 5-9 parts of Angelica sinensis, 5-9 parts of Panax ginseng, 5-9 parts of Panax quinquefolius, 5-9 parts of Artemisia capillaris, 5-9 parts of Artemisia argyi, 5-9 parts of Indigo naturalis, 2-5 parts of pearl powder, 2-5 parts of borneol, 5-9 parts of rosin, 150-200 parts of beeswax, 20-50 parts of high-proof liquor, and 900-1200 parts of vegetable oil.

[0008] The relevant medicinal effects of the above-mentioned drug components are as follows:

[0009] Puffball powder is mainly used to clear the lungs and soothe the throat, detoxify, and stop bleeding. It is suitable for treating symptoms such as lung heat cough, sore throat, and bleeding, and helps to reduce inflammation and promote wound healing.

[0010] Cattail pollen charcoal powder has the effects of astringing and stopping bleeding, promoting blood circulation and relieving pain, and promoting diuresis and reducing swelling. It can be used to treat various bleeding symptoms, including traumatic bleeding.

[0011] Moutan bark powder has the effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis. It is suitable for treating symptoms such as heat entering the blood in febrile diseases, rashes, vomiting blood and nosebleeds.

[0012] Peppermint powder has the effects of dispelling wind-heat, clearing the head and eyes, and soothing the liver and relieving depression. It is suitable for treating symptoms such as wind-heat cold, fever, headache, red eyes, and sore throat. In the case of burns, it helps to reduce inflammation and promote wound healing.

[0013] Fangfeng powder has the effects of dispelling wind and relieving exterior symptoms, eliminating dampness and relieving pain.

[0014] Purple gromwell has the effects of cooling blood and promoting blood circulation, detoxifying and relieving rashes, promoting wound healing, and antibacterial and anti-inflammatory properties.

[0015] Coptis chinensis has the effects of clearing heat and drying dampness, purging fire and detoxifying.

[0016] Scutellaria baicalensis has the effects of clearing heat and drying dampness, purging fire and detoxifying, stopping bleeding and calming the fetus.

[0017] Astragalus has the effects of tonifying qi and strengthening the exterior, promoting diuresis and eliminating toxins, and draining pus and promoting tissue regeneration.

[0018] Phellodendron bark has the effects of clearing heat and drying dampness, purging fire and detoxifying, and eliminating bone steaming.

[0019] Gardenia has the effects of purging fire and relieving irritability, clearing heat and promoting diuresis, cooling blood and detoxifying.

[0020] Sophora flavescens has the effects of clearing heat and drying dampness, killing parasites and relieving itching. It is suitable for treating symptoms such as damp-heat diarrhea, jaundice and dark urine.

[0021] Chuanxiong has the effects of promoting blood circulation, regulating qi, dispelling wind, and relieving pain.

[0022] Sichuan pepper has the effects of warming the middle jiao (digestive system), dispelling cold, relieving pain, and killing parasites.

[0023] Danshen has the effects of promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain, and clearing the mind and relieving irritability.

[0024] Angelica sinensis has the effects of nourishing blood, promoting blood circulation, regulating menstruation, and relieving pain.

[0025] Ginseng has the effects of greatly replenishing vital energy, restoring pulse, and preventing collapse.

[0026] American ginseng has the effects of replenishing qi and nourishing yin, clearing heat and promoting body fluid production.

[0027] Artemisia capillaris has the effects of clearing heat and dampness, promoting bile secretion and relieving jaundice.

[0028] Artemisia argyi has the effects of warming the meridians and stopping bleeding, dispelling cold and relieving pain.

[0029] Indigo naturalis has the effects of clearing heat and detoxifying, cooling blood and eliminating spots, and is suitable for treating symptoms such as dysentery caused by heat toxins.

[0030] Pearl powder has the effects of calming the nerves, relieving anxiety, and improving eyesight.

[0031] Borneol has the effects of clearing the mind and relieving pain, and is suitable for treating symptoms such as delirium caused by febrile diseases.

[0032] Rosin has the effects of dispelling wind and dampness, promoting tissue regeneration and relieving pain.

[0033] Beeswax has astringent, wound-healing, tissue-regenerating, and pain-relieving effects, and is suitable for treating symptoms such as non-healing sores.

[0034] Furthermore, the medicinal powder comprises the following components in parts by weight: 9 parts puffball powder, 9 parts cattail pollen charcoal powder, 1.5 parts peony bark powder, 3 parts peppermint powder, and 3 parts saposhnikovia root powder;

[0035] The ointment comprises the following components in parts by weight: 12 parts Lithospermum erythrorhizon, 8 parts Coptis chinensis, 8 parts Scutellaria baicalensis, 8 parts Astragalus membranaceus, 8 parts Phellodendron chinense, 9 parts Gardenia jasminoides, 9 parts Sophora flavescens, 8 parts Ligusticum chuanxiong, 8 parts Zanthoxylum bungeanum, 6 parts Salvia miltiorrhiza, 8 parts Angelica sinensis, 6 parts Panax ginseng, 6 parts American ginseng, 6 parts Artemisia capillaris, 6 parts Artemisia argyi, 8 parts Indigo naturalis, 3 parts pearl powder, 3 parts borneol, 6 parts rosin, 160 parts beeswax, 30 parts high-proof liquor, and 1100 parts vegetable oil.

[0036] Furthermore, the preparation method of the peony root powder is as follows:

[0037] A1. Weigh out peony bark, cattail pollen charcoal, and saposhnikovia root according to a mass ratio of 55:(4-6):(2-5, and mix them to obtain the raw materials;

[0038] A2. Add 3-5 times the weight of water to the raw material obtained in A1, heat to 70-80℃, keep warm and soak for 1-2 hours to obtain the soaking material;

[0039] A3. Add 5-7 times the weight of water to the soaking material obtained in A2, and extract by distillation and reflux for 7-9 hours to obtain the liquid.

[0040] A4. Concentrate the liquid obtained in A3 to 2-3 times the mass of the raw material, let it stand for 8-10 hours to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.16-1.18 at 60℃, spray dry, collect the powder, and pulverize to obtain the peony bark powder.

[0041] Furthermore, in A1, the mass ratio of peony bark, cattail pollen charcoal, and saposhnikovia root is 55:4:4.

[0042] Secondly, the present invention provides a method for preparing the above-mentioned burn drug composition, wherein a powder and an ointment are prepared respectively, wherein the powder is a powder and the ointment is an ointment.

[0043] Furthermore, the preparation method of the medicinal powder is as follows: mix puffball powder, cattail pollen carbon powder, peony bark powder, peppermint powder and saposhnikovia powder evenly, and pass through a 60-mesh sieve to obtain the medicinal powder.

[0044] Furthermore, the preparation method of the ointment is as follows:

[0045] S1. Mix the following herbs: Lithospermum erythrorhizon, Coptis chinensis, Scutellaria baicalensis, Astragalus membranaceus, Phellodendron chinense, Gardenia jasminoides, Sophora flavescens, Ligusticum chuanxiong, Zanthoxylum bungeanum, Salvia miltiorrhiza, Angelica sinensis, Panax ginseng, American ginseng, Artemisia capillaris, and Artemisia argyi. Add high-proof liquor and let stand for 1 hour to obtain the soaking material.

[0046] S2. Add the soaking material obtained in S1 into vegetable oil, heat it, and cook it until the vegetable oil is clear. Then filter it to obtain the filtrate.

[0047] S3. Add indigo, pearl powder and borneol to the filtrate obtained in S2, mix well and obtain the initial material.

[0048] S4. Melt the rosin and beeswax, add them to the initial material obtained in S3, mix well, and cool to obtain the ointment.

[0049] Furthermore, in S1, the alcohol content of the high-proof liquor is 55-65 degrees.

[0050] Furthermore, the vegetable oil includes any one of sesame oil, olive oil, and tea oil.

[0051] This application has the following beneficial effects:

[0052] 1. This invention is made of pure herbal plant components, ensuring no toxic side effects and safety and reliability; the burn medicine composition of this invention includes powder and ointment. The powder can quickly stop bleeding, relieve pain and fight infection, which helps to improve the speed of effectiveness, while the ointment can make the early lost vascularizations crawl and regenerate blood vessels, which helps to improve the final efficacy; the test results have verified that the combination of powder and ointment is effective and effective for burn wounds.

[0053] 2. The medicinal powder of this invention includes peony bark powder. In the preparation of peony bark powder, the most beneficial method is to mix peony bark, cattail pollen charcoal and saposhnikovia root and then perform water extraction. Experiments have verified that deleting cattail pollen charcoal and saposhnikovia root, or deleting the water extraction process, or extracting the three substances separately with water and then mixing them, will have a certain negative impact on the speed of the medicine's effect and the final efficacy. Attached Figure Description

[0054] Figure 1 The product images of the burn pharmaceutical composition of the present invention are shown, wherein (a) is a powder image and (b) is an ointment image.

[0055] Figure 2 One of the images showing the cooking process of vegetable oil during the preparation of the ointment of this invention;

[0056] Figure 3 1. A second diagram showing the cooking process of vegetable oil during the preparation of the ointment of this invention;

[0057] Figure 4 A comparative trend chart of healing rate data for each test subject (Examples 1-7) in Experiment 1 of this invention;

[0058] Figure 5 A comparative trend chart of healing rate data for each test subject (Example 1 and Comparative Examples 1-6) in Test Example 1 of this invention;

[0059] Figure 6 The diagram shows the stages of treatment of penetrating wounds on the rump of domestic pigs using the pharmaceutical composition of the present invention. The treatment stages are in the following order: (c) penetrating wound - (d) medication application - (e) bandaging - (f) healing. Detailed Implementation

[0060] The present application will be further described in detail below with reference to the embodiments.

[0061] Unless otherwise specified, the raw materials used in the embodiments and comparative examples of this application are all commercially available.

[0062] Example 1: (1) Preparation of peony bark powder, the preparation method steps are as follows: A1. Weigh peony bark, cattail pollen charcoal and saposhnikovia root according to the mass ratio of 55:4:4, and mix them to obtain raw materials.

[0063] A2. Add 4 times the weight of water to the raw material obtained in A1, heat to 75°C, and soak for 1.5 hours to obtain the soaking material.

[0064] A3. Add 6 times the weight of water to the soaking material obtained in A2, and extract by distillation and reflux for 8 hours to obtain the liquid.

[0065] A4. Concentrate the liquid obtained in A3 to 2.5 times the mass of the raw material, let it stand for 9 hours to allow precipitation, take the supernatant and concentrate it under reduced pressure to a relative density of about 1.17 at 60℃, spray dry, collect the powder, and pulverize to obtain the peony bark powder.

[0066] (2) Preparation of a burn drug composition, comprising a powder and an ointment. The powder is in the form of a powder, and the ointment is in the form of a paste.

[0067] The preparation method of the medicinal powder is as follows: by weight, mix 9 parts of puffball powder, 9 parts of cattail pollen charcoal powder, 1.5 parts of peony bark powder, 3 parts of peppermint powder and 3 parts of saposhnikovia powder, and pass through a 60-mesh sieve to obtain the medicinal powder.

[0068] The preparation method of the ointment is as follows: S1. By weight, mix 12 parts of Lithospermum erythrorhizon, 8 parts of Coptis chinensis, 8 parts of Scutellaria baicalensis, 8 parts of Astragalus membranaceus, 8 parts of Phellodendron chinense, 9 parts of Gardenia jasminoides, 9 parts of Sophora flavescens, 8 parts of Ligusticum chuanxiong, 8 parts of Zanthoxylum bungeanum, 6 parts of Salvia miltiorrhiza, 8 parts of Angelica sinensis, 6 parts of Panax ginseng, 6 parts of American ginseng, 6 parts of Artemisia capillaris, and 6 parts of Artemisia argyi. Add 30 parts of high-proof liquor and let stand for 1 hour to obtain the soaking material. The alcohol content of the high-proof liquor is 60 degrees.

[0069] S2. According to the same standard weight proportions, add the soaking material obtained in S1 to 1100 parts of vegetable oil, heat, and fry until the vegetable oil is clear. Then filter to obtain the filtrate. Olive oil is used as the vegetable oil, and the frying is carried out at a boiling state for a total of 40 minutes.

[0070] S3. According to the same standard weight proportions, add 8 parts of indigo, 3 parts of pearl powder and 3 parts of borneol to the filtrate obtained in S2, mix well and obtain the initial material.

[0071] S4. According to the same standard weight proportions, melt 6 parts of rosin and 160 parts of beeswax, add them to the initial material obtained in S3, mix well, and cool to obtain the ointment.

[0072] Example 2: The difference between this example and Example 1 is that: the preparation of peony bark powder is carried out by the following steps: A1. Peony bark, cattail pollen charcoal and saposhnikovia root are weighed according to the mass ratio of 55:4:2 and mixed to obtain the raw materials.

[0073] A2. Add water three times the mass of the raw material to the raw material obtained in A1, heat to 70°C, keep warm and soak for 1 hour to obtain the soaking material.

[0074] A3. Add 5 times the weight of water to the soaking material obtained in A2, and extract by distillation and reflux for 7 hours to obtain the liquid.

[0075] A4. Concentrate the liquid obtained in A3 to twice the mass of the raw material, let it stand for 8 hours to allow precipitation, take the supernatant and concentrate it under reduced pressure to a relative density of about 1.16 at 60℃, spray dry, collect the powder, and pulverize to obtain the peony bark powder.

[0076] Example 3: The difference between this example and Example 1 is that: the preparation of peony bark powder is as follows: A1. Weigh peony bark, cattail pollen charcoal and saposhnikovia root in a mass ratio of 55:6:5 and mix them to obtain the raw materials.

[0077] A2. Add 5 times the weight of water to the raw material obtained in A1, heat to 80℃, keep warm and soak for 2 hours to obtain the soaking material.

[0078] A3. Add water at 7 times the mass of the raw material to the soaking material obtained in A2, and extract by distillation and reflux for 9 hours to obtain the liquid.

[0079] A4. Concentrate the liquid obtained in A3 to 3 times the mass of the raw material, let it stand for 10 hours to allow precipitation, take the supernatant and concentrate it under reduced pressure to a relative density of about 1.18 at 60℃, spray dry, collect the powder, and pulverize to obtain the peony bark powder.

[0080] Example 4: The difference between this example and Example 1 is that the preparation method of the powder is as follows: by weight, 6 parts of puffball powder, 6 parts of cattail pollen charcoal powder, 1 part of peony bark powder, 3 parts of peppermint powder and 3 parts of saposhnikovia powder are mixed and passed through a 60-mesh sieve to obtain the powder.

[0081] Example 5: The difference between this example and Example 1 is that the preparation method of the powder is as follows: by weight, 9 parts of puffball powder, 9 parts of cattail pollen charcoal powder, 2 parts of peony bark powder, 5 parts of peppermint powder and 5 parts of saposhnikovia powder are mixed and passed through a 60-mesh sieve to obtain the powder.

[0082] Example 6: The difference between this example and Example 1 is that the preparation method of the ointment is as follows: S1. By weight, mix 6 parts of Lithospermum erythrorhizon, 5 parts of Coptis chinensis, 5 parts of Scutellaria baicalensis, 5 parts of Astragalus membranaceus, 5 parts of Phellodendron chinense, 5 parts of Gardenia jasminoides, 5 parts of Sophora flavescens, 5 parts of Ligusticum chuanxiong, 5 parts of Zanthoxylum bungeanum, 5 parts of Salvia miltiorrhiza, 5 parts of Angelica sinensis, 5 parts of Panax ginseng, 5 parts of Panax quinquefolius, 5 parts of Artemisia capillaris, and 5 parts of Artemisia argyi. Add 20 parts of high-proof liquor and let stand for 1 hour to obtain the soaking material. The alcohol content of the high-proof liquor is 55 degrees.

[0083] S2. According to the same standard weight proportions, add the soaking material obtained in S1 to 900 parts of vegetable oil, heat, and simmer until the vegetable oil is clear. Filter to obtain the filtrate. Sesame oil is used as the vegetable oil, and the simmering process is at a boiling state for a total of 45 minutes.

[0084] S3. According to the same standard weight proportions, add 5 parts of indigo, 2 parts of pearl powder and 2 parts of borneol to the filtrate obtained in S2, mix well and obtain the initial material.

[0085] S4. According to the same standard weight proportions, melt 5 parts of rosin and 150 parts of beeswax, add them to the initial material obtained in S3, mix well, and cool to obtain the ointment.

[0086] Example 7: The difference between this example and Example 1 is that the preparation method of the ointment is as follows: S1. By weight, mix 12 parts of Lithospermum erythrorhizon, 9 parts of Coptis chinensis, 9 parts of Scutellaria baicalensis, 9 parts of Astragalus membranaceus, 9 parts of Phellodendron chinense, 9 parts of Gardenia jasminoides, 9 parts of Sophora flavescens, 9 parts of Ligusticum chuanxiong, 9 parts of Zanthoxylum bungeanum, 9 parts of Salvia miltiorrhiza, 9 parts of Angelica sinensis, 9 parts of Panax ginseng, 9 parts of American ginseng, 9 parts of Artemisia capillaris, and 9 parts of Artemisia argyi. Add 50 parts of high-proof liquor and let stand for 1 hour to obtain the soaking material. The alcohol content of the high-proof liquor is 65 degrees.

[0087] S2. According to the same standard weight proportions, add the soaking material obtained in S1 to 1200 parts of vegetable oil, heat, and simmer until the vegetable oil is clear. Filter to obtain the filtrate. Sesame oil is used as the vegetable oil, and the simmering process is at a boiling state for a total of 45 minutes.

[0088] S3. According to the same standard weight proportions, add 9 parts of indigo, 5 parts of pearl powder and 5 parts of borneol to the filtrate obtained in S2, mix well and obtain the initial material.

[0089] S4. According to the same standard weight proportions, melt 9 parts of rosin and 200 parts of beeswax, add them to the initial material obtained in S3, mix well, and cool to obtain the ointment.

[0090] Comparative Example 1: The difference between this comparative example and Example 1 is that the ointment has been removed, that is, the burn drug composition only includes the powder.

[0091] The preparation method of the medicinal powder is as follows: by weight, mix 9 parts of puffball powder, 9 parts of cattail pollen charcoal powder, 1.5 parts of peony bark powder, 3 parts of peppermint powder and 3 parts of saposhnikovia powder, and pass through a 60-mesh sieve to obtain the medicinal powder.

[0092] Comparative Example 2: The difference between this comparative example and Example 1 is that the powder was removed, that is, the burn drug composition only includes the ointment.

[0093] The preparation method of the ointment is as follows: S1. By weight, mix 12 parts of Lithospermum erythrorhizon, 8 parts of Coptis chinensis, 8 parts of Scutellaria baicalensis, 8 parts of Astragalus membranaceus, 8 parts of Phellodendron chinense, 9 parts of Gardenia jasminoides, 9 parts of Sophora flavescens, 8 parts of Ligusticum chuanxiong, 8 parts of Zanthoxylum bungeanum, 6 parts of Salvia miltiorrhiza, 8 parts of Angelica sinensis, 6 parts of Panax ginseng, 6 parts of American ginseng, 6 parts of Artemisia capillaris, and 6 parts of Artemisia argyi. Add 30 parts of high-proof liquor and let stand for 1 hour to obtain the soaking material. The alcohol content of the high-proof liquor is 60 degrees.

[0094] S2. According to the same standard weight proportions, add the soaking material obtained in S1 to 1100 parts of vegetable oil, heat, and fry until the vegetable oil is clear. Then filter to obtain the filtrate. Olive oil is used as the vegetable oil, and the frying is carried out at a boiling state for a total of 40 minutes.

[0095] S3. According to the same standard weight proportions, add 8 parts of indigo, 3 parts of pearl powder and 3 parts of borneol to the filtrate obtained in S2, mix well and obtain the initial material.

[0096] S4. According to the same standard weight proportions, melt 6 parts of rosin and 160 parts of beeswax, add them to the initial material obtained in S3, mix well, and cool to obtain the ointment.

[0097] Comparative Example 3: The difference between this comparative example and Example 1 is that the raw material components of the powder are directly used in the preparation of the ointment.

[0098] Specifically, the burn medication composition only includes an ointment.

[0099] The preparation method of the ointment is as follows: S1. By weight, mix 9 parts of puffball powder, 9 parts of cattail pollen charcoal powder, 1.5 parts of peony bark powder, 3 parts of peppermint powder, 3 parts of saposhnikovia root powder, 12 parts of gromwell root, 8 parts of coptis root, 8 parts of scutellaria root, 8 parts of astragalus root, 8 parts of phellodendron bark, 9 parts of gardenia fruit, 9 parts of sophora root, 8 parts of chuanxiong rhizome, 8 parts of Sichuan pepper, 6 parts of salvia root, 8 parts of angelica root, 6 parts of ginseng, 6 parts of American ginseng, 6 parts of artemisia capillaris, and 6 parts of mugwort leaf. Add 30 parts of high-proof liquor and let stand for 1 hour to obtain the soaking material. The alcohol content of the high-proof liquor is 60 degrees.

[0100] S2. According to the same standard weight proportions, add the soaking material obtained in S1 to 1100 parts of vegetable oil, heat, and fry until the vegetable oil is clear. Then filter to obtain the filtrate. Olive oil is used as the vegetable oil, and the frying is carried out at a boiling state for a total of 40 minutes.

[0101] S3. According to the same standard weight proportions, add 8 parts of indigo, 3 parts of pearl powder and 3 parts of borneol to the filtrate obtained in S2, mix well and obtain the initial material.

[0102] S4. According to the same standard weight proportions, melt 6 parts of rosin and 160 parts of beeswax, add them to the initial material obtained in S3, mix well, and cool to obtain the ointment.

[0103] Comparative Example 4: The difference between this comparative example and Example 1 is that the peony bark powder is directly obtained by drying and pulverizing peony bark.

[0104] Comparative Example 5: The difference between this comparative example and Example 1 is that in the preparation of peony bark powder, cattail pollen carbon and saposhnikovia root are removed.

[0105] Specifically, the preparation method for peony bark powder is as follows: A1. Add water equal to 4 times the weight of peony bark to peony bark, heat to 75℃, and soak for 1.5 hours to obtain soaking material.

[0106] A2. Add 6 times the weight of peony bark in water to the soaking material obtained in A1, and extract by distillation and reflux for 8 hours to obtain the liquid.

[0107] A3. Concentrate the liquid obtained in A2 to 2.5 times the mass of peony bark, let it stand for 9 hours to allow precipitation, take the supernatant and concentrate it under reduced pressure to a relative density of about 1.17 at 60℃, spray dry, collect the powder, pulverize, and obtain peony bark powder.

[0108] Comparative Example 6: The difference between this comparative example and Example 1 is that the peony bark powder is prepared by extracting peony bark, cattail pollen charcoal and saposhnikovia root into powder by water and then mixing them together.

[0109] Specifically, the preparation method for peony bark powder is as follows: Take three raw materials, peony bark, cattail pollen charcoal, and saposhnikovia root, and perform water extraction operations to obtain water-extracted powders of the three raw materials, namely peony bark water-extracted powder, cattail pollen charcoal water-extracted powder, and saposhnikovia root water-extracted powder. Then, mix the peony bark water-extracted powder, cattail pollen charcoal water-extracted powder, and saposhnikovia root water-extracted powder in a mass ratio of 55:4:4 to obtain peony bark powder.

[0110] The specific steps of the water extraction operation are as follows: A1. Add water to the raw material in a volume of 4 times the weight of the raw material, heat to 75°C, keep warm and soak for 1.5 hours to obtain the soaked material.

[0111] A2. Add water at a ratio of 6 times the mass of the raw material to the soaking material obtained in A1, and extract by distillation and reflux for 8 hours to obtain the liquid.

[0112] A3. Concentrate the liquid obtained in A2 to 2.5 times the mass of the raw material, let it stand for 9 hours to settle, take the supernatant and concentrate it under reduced pressure to a relative density of about 1.17 at 60℃, spray dry, collect the powder, and pulverize to obtain the water-extracted powder of the raw material.

[0113] Experimental Example 1: Experimental Item: The effect of each experimental subject on the healing of burn wounds in mice.

[0114] Test subjects: Pharmaceutical compositions prepared in Examples 1-7 and Comparative Examples 1-6.

[0115] Experimental Methods: Seventy-five SPF-grade Kunming mice (18-22g) were used. On the first day, five mice were randomly selected as the control group and no model treatment was performed. The remaining 70 mice were treated with the model, with a hair removal area of ​​approximately 3cm*4cm on the back of each mouse. The mice were observed for 24 hours to ensure there were no abnormalities such as redness, swelling, inflammation, or damage at the hair removal site. On the second day, after intraperitoneal anesthesia at room temperature, the mice were placed in a prone position. A 20g weight was placed in a container and heated to boiling, maintained for 10 minutes. After disinfecting the skin of the hair removal area with 75% ethanol, the heated weight was quickly placed on the mouse skin with slight pressure, forming a superficial second-degree burn model with a burn area of ​​approximately 2cm*2cm. The normal area and the burn site were clearly distinguishable, and significant subcutaneous edema was observed within 4 hours of the burn.

[0116] Of the 70 mice treated with the model, 5 were randomly selected as the model group and received no medication. The remaining 65 mice were divided into 13 groups of 5 each, and administered the corresponding drug compositions (the drug compositions prepared in Examples 1-7 and Comparative Examples 1-6). All mice were housed under identical conditions. The powder was sprayed directly to cover the wound; the ointment was applied directly to cover the wound; for a combination of powder and ointment, the powder was sprayed first, followed by the ointment. Administering was done every 8 hours. Before administration, any residual drug and liquefied material on the wound surface was wiped away to expose the wound. The model group received 0.9% saline solution for wound application. Administration continued for 15 days, and skin healing was observed, calculated, and statistically analyzed on days 2, 5, 10, and 15. Healing was expressed as a healing rate. During these 15 days, the 5 mice in the control group showed normal growth and no abnormalities.

[0117] Healing rate calculation method: On days 2, 5, 10, and 15 after drug administration, the area of ​​local skin lesions was measured using a recording and weighing method. Specifically, the lesion area was first marked with transparent film, then a piece of transparent film corresponding to the size of the lesion area was cut off and its mass was weighed; the mass was used to represent the area. Healing rate = (initial wound area - unhealed wound area) / initial wound area * 100%. The average value was calculated for each group.

[0118] Experimental results: see Table 1.

[0119] Table 1. Test data for Experiment Example 1

[0120]

[0121] Results Analysis: Analyze Examples 1-7 and combine the data in Table 1 and... Figure 4 As can be seen, the burn drug composition prepared by the present invention includes a powder and an ointment. For burn wounds, each time the drug is administered, a layer of powder is sprayed on the wound first, and then a layer of ointment is applied. It is fast-acting, and the healing rate can reach more than 9.6% on the second day of administration. Moreover, the therapeutic effect is significant, and the healing rate after 15 days of continuous administration is as high as 92.2%.

[0122] Analysis of Example 1 and Comparative Examples 1-3, combined with data from Table 1 and Figure 5 It can be seen that using only the powder and not the ointment (Comparative Example 1) resulted in a healing rate of 9.1% on the second day of administration, with little impact on the speed of effectiveness, only a slight decrease; however, the efficacy decreased significantly after 15 days of administration, with a healing rate of only 71.5%.

[0123] Using only the ointment and not the powder (Comparative Example 2), compared to the former (Comparative Example 1), the efficacy was improved after 15 days of administration, with a healing rate of 78.7%, but it was still lower than the efficacy (healing rate) of using the powder and ointment of this invention in combination (Example 1); moreover, the healing rate on the second day of administration was only 6.4%, and the speed of effectiveness in the early stage of administration was significantly reduced.

[0124] Comparative Example 3 involved directly using the raw materials of the powder in the preparation of the ointment. As a result, the speed of onset of action (healing rate on the second day of administration) and the final efficacy (healing rate on the 15th day of administration) were both lower than those in Example 1, indicating that the method of using the powder and ointment together is more beneficial for treating burn wounds.

[0125] Analysis of Example 1 and Comparative Examples 4-6, combined with data from Table 1 and Figure 5 It can be seen that the powder components of this invention include peony bark powder. In the preparation of peony bark powder, mixing peony bark, cattail pollen charcoal and saposhnikovia root and then performing water extraction is most beneficial to the speed of onset and final efficacy of the medicine. Deleting cattail pollen charcoal and saposhnikovia root, or deleting the water extraction process, or extracting the three substances separately with water and then mixing them, will all have a certain negative impact on the speed of onset and final efficacy of the medicine.

[0126] Experimental Example 2: The burn drug composition prepared in Example 1 of the present invention was used to treat penetrating injuries to the buttocks of domestic pigs.

[0127] Each time medication is administered, first spray a layer of powder, then apply a layer of ointment; administer medication once every 8 hours; because it is a penetrating wound, in order to avoid the influence of the external environment and to prevent the medication from falling off, the wound needs to be bandaged after each administration.

[0128] Before each administration, any remaining medication and effusion on the wound surface must be wiped away to prevent secretions or residual medication from affecting the efficacy of subsequent treatments. Significant therapeutic effects were observed after 20 days of continuous administration. Figure 6 .

[0129] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

[0130] Furthermore, various different embodiments of the present invention can be combined in any way, as long as they do not violate the spirit of the present invention, they should also be regarded as the content disclosed by the present invention.

Claims

1. A burn medication composition, characterized in that, Composed of powder and ointment; The powder is made from the following components in parts by weight: 6-9 parts puffball powder, 6-9 parts cattail pollen charcoal powder, 1-2 parts peony bark powder, 3-5 parts peppermint powder, and 3-5 parts saposhnikovia root powder. The ointment is made from the following components in parts by weight: 6-12 parts of Lithospermum erythrorhizon, 5-9 parts of Coptis chinensis, 5-9 parts of Scutellaria baicalensis, 5-9 parts of Astragalus membranaceus, 5-9 parts of Phellodendron chinense, 5-9 parts of Gardenia jasminoides, 5-9 parts of Sophora flavescens, 5-9 parts of Ligusticum chuanxiong, 5-9 parts of Zanthoxylum bungeanum, 5-9 parts of Salvia miltiorrhiza, 5-9 parts of Angelica sinensis, 5-9 parts of Panax ginseng, 5-9 parts of Panax quinquefolius, 5-9 parts of Artemisia capillaris, 5-9 parts of Artemisia argyi, 5-9 parts of Indigo naturalis, 2-5 parts of pearl powder, 2-5 parts of borneol, 5-9 parts of rosin, 150-200 parts of beeswax, 20-50 parts of high-proof liquor, and 900-1200 parts of vegetable oil; The preparation method of the peony bark powder is as follows: A1. Weigh out peony bark, cattail pollen charcoal, and saposhnikovia root according to a mass ratio of 55:(4-6):(2-5, and mix them to obtain the raw materials; A2. Add 3-5 times the weight of water to the raw material obtained in A1, heat to 70-80℃, keep warm and soak for 1-2 hours to obtain the soaking material; A3. Add 5-7 times the weight of water to the soaking material obtained in A2, and extract by distillation and reflux for 7-9 hours to obtain the liquid. A4. Concentrate the liquid obtained in A3 to 2-3 times the mass of the raw material, let it stand for 8-10 hours to precipitate, take the supernatant and concentrate it under reduced pressure to a relative density of 1.16-1.18 at 60℃, spray dry, collect the powder, and pulverize to obtain the peony bark powder. When using the powder and ointment together, first spray the powder onto the burn wound, then apply the ointment over the powder.

2. The burn medication composition according to claim 1, characterized in that, The powder is made from the following components in parts by weight: 9 parts puffball powder, 9 parts cattail pollen charcoal powder, 1.5 parts peony bark powder, 3 parts peppermint powder, and 3 parts saposhnikovia root powder. The ointment is made from the following components in parts by weight: 12 parts Lithospermum erythrorhizon, 8 parts Coptis chinensis, 8 parts Scutellaria baicalensis, 8 parts Astragalus membranaceus, 8 parts Phellodendron chinense, 9 parts Gardenia jasminoides, 9 parts Sophora flavescens, 8 parts Ligusticum chuanxiong, 8 parts Zanthoxylum bungeanum, 6 parts Salvia miltiorrhiza, 8 parts Angelica sinensis, 6 parts Panax ginseng, 6 parts Panax quinquefolius, 6 parts Artemisia capillaris, 6 parts Artemisia argyi, 8 parts Indigo naturalis, 3 parts Pearl powder, 3 parts Borneol, 6 parts Rosin, 160 parts Beeswax, 30 parts High-proof liquor, and 1100 parts Vegetable oil.

3. The burn medication composition according to claim 1, characterized in that, In A1, the mass ratio of peony bark, cattail pollen charcoal, and saposhnikovia root is 55:4:

4.

4. A method for preparing a burn pharmaceutical composition according to any one of claims 1-3, characterized in that, The medicinal powder and the medicinal paste are prepared separately, wherein the medicinal powder is in the form of powder and the medicinal paste is in the form of paste.

5. The method for preparing the burn pharmaceutical composition according to claim 4, characterized in that, The preparation method of the medicinal powder is as follows: mix puffball powder, cattail pollen charcoal powder, peony bark powder, peppermint powder and saposhnikovia powder evenly, and pass through a 60-mesh sieve to obtain the medicinal powder.

6. The method for preparing the burn pharmaceutical composition according to claim 4, characterized in that, The ointment is prepared as follows: S1. Mix the following herbs: Lithospermum erythrorhizon, Coptis chinensis, Scutellaria baicalensis, Astragalus membranaceus, Phellodendron chinense, Gardenia jasminoides, Sophora flavescens, Ligusticum chuanxiong, Zanthoxylum bungeanum, Salvia miltiorrhiza, Angelica sinensis, Panax ginseng, American ginseng, Artemisia capillaris, and Artemisia argyi. Add high-proof liquor and let stand for 1 hour to obtain the soaking material. S2. Add the soaking material obtained in S1 into vegetable oil, heat it, and cook it until the vegetable oil is clear. Then filter it to obtain the filtrate. S3. Add indigo, pearl powder and borneol to the filtrate obtained in S2, mix well and obtain the initial material. S4. Melt the rosin and beeswax, add them to the initial material obtained in S3, mix well, and cool to obtain the ointment.

7. The method for preparing the burn pharmaceutical composition according to claim 6, characterized in that, In S1, the alcohol content of the high-proof liquor is 55-65 degrees.

8. The method for preparing the burn pharmaceutical composition according to claim 6, characterized in that, The vegetable oil is selected from any one of sesame oil, olive oil, and tea oil.

Images