Leak-proof fabric, stent graft and processing method thereof

Abstract

This invention provides a leak-proof fabric, a covered stent, and a processing method thereof, relating to the field of covered stent technology. The leak-proof fabric provided by this invention has a base area and a leak-proof area, which are integrally woven together. The leak-proof area is woven with foam components, which have a dehydration shrinkage state and a water absorption swelling state. The foam components are woven together, resulting in a tighter structure, more uniform water absorption and swelling, and no shedding. It is particularly suitable for use as a cover for covered stents, which can prevent endoleaks during endovascular repair surgery and promote platelet aggregation and fibrinogen deposition in blood vessels, thereby rapidly forming thrombi and helping to achieve vascular embolization.

Description

Technical Field

[0001] The present invention relates to the technical field of stent grafts, and in particular to a leak-proof fabric, a stent graft and a processing method thereof. Background Art

[0002] The prevention and treatment of endoleak after endovascular repair (EVAR) of abdominal aortic aneurysm is a technical problem that must be solved in the development of this diagnosis and treatment technology. Usually, a biocompatible highly absorbent polymer or prepolymer material is wrapped or sewn on the coated port to form a collar-like or tire-like sealing ring, which fills the gap between the blood vessel and the stent port by absorbing water and swelling. However, the problem with this method is that it is necessary to sew another layer of pouch on the outside of the coated stent, and place absorbent material in the pouch, or directly use highly absorbent material for the outer layer. The coated stent needs to be compressed into the conveyor during use. The volume of the coating material and the absorbent material affects the loading performance and conveying performance of the product. If the absorbent material is granular, there will be local accumulation and uneven distribution after release, resulting in poor effect in preventing endoleak. If the absorbent material is directly sewn to the outside of the stent coating, high requirements are placed on the strength of the absorbent material. This is because during the delivery and release process, the outside of the stent coating is in direct contact with the sheath, causing friction, which may cause the absorbent material to detach. If it falls into the human body, it will cause catastrophic consequences such as vascular embolism. Summary of the invention

[0003] The purpose of the present invention is to provide a leak-proof fabric, a coated stent and a processing method thereof, so as to solve the technical problems in the prior art that the leak-proof structure of the coated stent expands unevenly, is easy to fall off, and is difficult to compress and implant.

[0004] In a first aspect, the leakage-proof fabric provided by the present invention comprises a basic area and a leakage-proof area, wherein the basic area and the leakage-proof area are woven integrally;

[0005] The anti-leakage area is woven and connected with a foaming piece, and the foaming piece has a dehydration shrinkage state and a water absorption expansion state.

[0006] In combination with the first aspect, the present invention provides a first possible implementation of the first aspect, wherein the leakage-proof fabric is formed by interweaving a plurality of warp yarns and a plurality of weft yarns;

[0007] In the leakage-proof area, the plurality of warp yarns are divided into a base fabric group and a fabric surface group;

[0008] Each of the warp yarns in the basic fabric group is interwoven with the weft yarns in an up-and-down manner;

[0009] The plurality of warp yarns in the fabric surface group are evenly distributed along the extending direction of the weft yarns and respectively extend and interweave in the base area, and the plurality of warp yarns in the fabric surface group cross over the plurality of weft yarns in the leakage-proof area to form floating lines.

[0010] In combination with the first possible implementation of the first aspect, the present invention provides a second possible implementation of the first aspect, wherein, in the basic area, the plurality of warp yarns and the plurality of weft yarns are interwoven in an up-and-down manner.

[0011] In combination with the first aspect, the present invention provides a third possible implementation of the first aspect, wherein, in the extension direction of the weft yarns, the foamed part is interwoven between any two adjacent warp yarns.

[0012] In a second aspect, the present invention provides a coated stent, comprising: a stent and a coating connected to the stent, wherein the coating is configured as the leak-proof fabric described in the first aspect.

[0013] In combination with the second aspect, the present invention provides a first possible implementation of the second aspect, wherein the proximal end and the distal end of the coated stent are respectively provided with an annular leak-proof area, and the annular leak-proof area is configured as the leak-proof area of ​​the leak-proof fabric.

[0014] In combination with the first possible implementation of the second aspect, the present invention provides a second possible implementation of the second aspect, wherein the stent includes a plurality of corrugated frames, and the plurality of corrugated frames are arranged at intervals along a direction from the proximal end to the distal end;

[0015] At least one of the annular anti-leakage areas is located between two adjacent corrugated frames in the direction from the proximal end to the distal end, and / or at least one of the annular anti-leakage areas is located between the crest and the trough of one of the corrugated frames.

[0016] In combination with the first possible implementation of the second aspect, the present invention provides a third possible implementation of the second aspect, wherein at least one of the brackets in the annular leak-proof area is configured as an unsupported structure or a weakly supported structure.

[0017] In combination with the first possible implementation of the second aspect, the present invention provides a fourth possible implementation of the second aspect, wherein the stent includes a plurality of corrugated frames, and the plurality of corrugated frames are arranged at intervals along a direction from the proximal end to the distal end;

[0018] The annular leak-proof area includes: a first annular portion and a second annular portion, both of which surround one of the corrugated frames at the proximal end of the coated stent, and the first annular portion and the second annular portion are spaced apart in a direction from the proximal end to the distal end.

[0019] In combination with the second aspect, the present invention provides a fifth possible implementation of the second aspect, wherein the stent graft is provided with a window area, and the window area is configured as the leak-proof area of ​​the leak-proof fabric.

[0020] In a third aspect, the present invention provides a method for processing a stent graft, comprising the following steps:

[0021] Weaving a leakproof fabric having a base area and a leakproof area in an integrally woven manner, and loading a foaming element in the leakproof area;

[0022] The leakproof fabric is connected to the support.

[0023] The embodiments of the present invention bring the following beneficial effects: the leak-proof fabric has a basic area and a leak-proof area, the basic area and the leak-proof area are woven together, the leak-proof area is woven and connected with a foam part, the foam part has a dehydration shrinkage state and a water absorption expansion state, the foam parts are woven and connected, the structure is tighter, the water absorption expansion is more uniform, and it will not fall off, which is particularly suitable for use as a coating for a coated stent, which can avoid the occurrence of internal leakage in intracavitary repair surgery, and is beneficial to causing platelet aggregation and fibrinogen deposition in the blood vessel, thereby quickly forming a thrombus and helping to achieve vascular embolism.

[0024] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, preferred embodiments are given below and described in detail with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the related technologies, the drawings required for use in the specific embodiments or the related technical descriptions will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0026] Figure 1 A partial schematic diagram of a leak-proof fabric provided by an embodiment of the present invention;

[0027] Figure 2 A schematic plan view of a leak-proof fabric provided by an embodiment of the present invention;

[0028] Figure 3 A cross-sectional view of the leak-proof fabric provided by an embodiment of the present invention in a direction perpendicular to the weft yarn;

[0029] Figure 4 A cross-sectional view of the leakproof fabric provided by an embodiment of the present invention in a direction perpendicular to the warp yarn;

[0030] Figure 5A schematic diagram of a first stent graft provided by an embodiment of the present invention;

[0031] Figure 6 A schematic diagram of a second stent graft provided by an embodiment of the present invention;

[0032] Figure 7 A schematic diagram of a third stent graft provided in an embodiment of the present invention.

[0033] Icons: 001-warp yarn; 002-weft yarn; 100-basic area; 200-leakage-proof area; 300-foamed part; 400-bracket; 401-unsupported structure; 402-weakly supported structure; 410-corrugated frame; 411-peak; 412-trough; 500-annular leakage-proof area; 510-first annular part; 520-second annular part; 600-window area. DETAILED DESCRIPTION

[0034] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] In the description of the present invention, it should be noted that the terms "center", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In addition, "proximal" and "distal" are referenced to operators or operating tools to obtain corresponding orientation references. "First", "second" and "third" are only used to describe the difference in names, and cannot be understood as indicating or implying relative importance. The physical quantities in the formula, if not separately marked, should be understood as basic quantities of the basic units of the International System of Units, or derived quantities derived from the basic quantities through mathematical operations such as multiplication, division, differentiation or integration.

[0036] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0037] like Figure 1 , Figure 2 , Figure 3 and Figure 4 As shown, the leakage-proof fabric provided in the embodiment of the present invention comprises a basic area 100 and a leakage-proof area 200, wherein the basic area 100 and the leakage-proof area 200 are woven integrally; the leakage-proof area 200 is woven and connected with a foaming part 300, and the foaming part 300 has a dehydration shrinkage state and a water absorption expansion state.

[0038] Among them, the foaming part 300 adopts a foaming water-absorbing material such as gelatin sponge, and can be configured as a filamentous or membrane-like structure. The overall thickness of the leak-proof fabric is configured to be 0.2mm to 0.3mm, so that it has better compressibility when used as a coating of the coated stent, so that it can be implanted by a thinner outer sheath. The foaming part 300 is connected in a woven manner in the leak-proof area 200, which ensures that the foaming part 300 is firmly and evenly connected. When the foaming part 300 absorbs water and expands, the expansion area of ​​the leak-proof area 200 is more evenly distributed, and the expanded foaming part 300 can be prevented from falling off. It is particularly suitable for use as a coating of the coated stent, which can avoid the occurrence of internal leakage in intracavitary repair surgery, and is conducive to causing platelet aggregation and fibrinogen deposition in the blood vessel, thereby quickly forming a thrombus and helping to achieve vascular embolism.

[0039] It should be noted that the leakage-proof area 200 can be configured as a circle, rectangle, ring or polygon as required, and the foaming part 300 is woven and connected in a corresponding specific shape area, which is easy to process and has high flexibility in structural design.

[0040] In the embodiment of the present invention, the leakproof fabric is formed by interweaving a plurality of warp yarns 001 and a plurality of weft yarns 002; in the leakproof area 200, the plurality of warp yarns 001 are divided into a basic fabric group and a fabric surface group, and the basic fabric group can be configured to be 1 / 3 to 1 / 2 of the total number of warp yarns 001 in the leakproof area 200, and the number ratio of the warp yarns 001 in the basic fabric group and the fabric surface group can also be adjusted according to the stability of the foaming part 300 and the test effect of the internal leakage prevention; each warp yarn 001 in the basic fabric group is interwoven with the weft yarn 002 in an up-and-down manner. In other words, after each warp yarn 001 passes over a weft yarn 002 from the upper layer, it will be interwoven to the lower layer of the next weft yarn 002, and after each weft yarn 002 passes over a warp yarn 001 from the upper layer, it will be interwoven to the lower layer of the next warp yarn 001, thereby realizing an up-and-down interweaving form.

[0041] The multiple warp yarns 001 in the fabric surface group are evenly distributed along the extension direction of the weft yarns, and extend and interweave with the weft yarns 002 in the basic area 100 respectively, and the multiple warp yarns 001 in the fabric surface group cross the multiple weft yarns 002 in the leakage-proof area 200 to form floating lines. The area where the floating lines are located is more convenient for the subsequent addition of foaming parts 300, and the floating lines can have a restraining effect on the added foaming parts 300, and can also ensure that the foaming parts 300 have sufficient exposed gaps on the fabric surface to facilitate their contact with liquid to achieve liquid absorption and expansion.

[0042] In an optional embodiment, the plurality of warp yarns 001 and the plurality of weft yarns 002 in the basic region 100 are interwoven in an up-and-down manner.

[0043] In alternative embodiments, the warp yarns 001 and the weft yarns 002 in the basic region 100 may also be arranged in other conventional interlacing forms.

[0044] See also Figure 4 and Figure 5 In the extension direction of the weft yarn 002, the foam piece 300 is interwoven between any two adjacent warp yarns 001, and the foam piece 300 is bound by the warp yarn 001 as a floating line, thereby ensuring that the foam piece 300 is firmly connected and preventing the foam piece 300 from loosening and falling off.

[0045] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 and Figure 7 As shown, the stent graft provided by the embodiment of the present invention includes: a stent 400 and a membrane connected to the stent 400, and the membrane is configured as the leakproof fabric described in the above embodiment. The membrane and the stent 400 can be relatively fixed by suturing, and the shape and position of the leakproof area 200 on the leakproof fabric can be set according to the position of the area where the stent graft needs to be leakproof.

[0046] like Figure 1 , Figure 3 , Figure 4 , Figure 5 , Figure 6 and Figure 7 As shown, in an optional embodiment, the proximal end and the distal end of the stent graft are respectively provided with an annular leak-proof area 500, and the annular leak-proof area 500 is configured as the leak-proof area 200 of the leak-proof fabric.

[0047] In a preferred embodiment, double annular anti-leakage areas 500 can be respectively arranged at the proximal and distal ends of the stent graft, thereby improving the reliability of anti-endoleakage at both ends. The foaming member 300 in the anti-leakage area 200 contacts the blood and expands in volume, so that the coating fits the shape of the blood vessel, thereby preventing the occurrence of endoleakage at the proximal and distal ends. It can also prevent endoleakage at the overlap position when the stent grafts overlap each other.

[0048] like Figure 5 and Figure 7 As shown, the stent 400 includes a plurality of corrugated frames 410, and the plurality of corrugated frames 410 are arranged at intervals along the direction from the proximal end to the distal end; at least one of the annular leak-proof areas 500 is located between two adjacent corrugated frames 410 in the direction from the proximal end to the distal end, and an unsupported structure 401 is formed between two adjacent corrugated frames 410, which can be compressed in a relatively thinner outer sheath.

[0049] As a replaceable or combined implementation, at least one annular leak-proof area 500 is located between the crest 411 and the trough 412 of one of the corrugated frames 410, avoiding the crest and trough areas of the stent 400. This can reduce the problem of large compressed volume of the coated stent during pre-installation, so that the coated stent can be matched with a thinner outer sheath, facilitating interventional implantation during surgery, making the operation simpler and reducing harm to the patient.

[0050] like Figure 6 and Figure 7 As shown, in an optional embodiment, the support 400 in at least one annular anti-leakage area 500 is configured as a non-support structure 401 or a weak support structure 402 .

[0051] The area without the corrugated frame 410 in the stent 400 can be regarded as the unsupported structure 401, and the area with thinner wire material of the corrugated frame 410 or weaker elasticity can be regarded as the weak support structure 402. Setting the position of the unsupported structure 401 or the weak support structure 402 as the annular leak-proof area 500 can ensure that the area is easy to compress and is convenient for implantation with a thinner outer sheath.

[0052] like Figure 7 As shown, in an optional embodiment, the stent 400 includes a plurality of corrugated frames 410, and the plurality of corrugated frames 410 are spaced apart along a direction from the proximal end to the distal end; the annular anti-leakage zone 500 includes: a first annular portion 510 and a second annular portion 520, and the first annular portion 510 and the second annular portion 520 are both surrounded by one of the corrugated frames 410 at the proximal end of the coated stent, and the first annular portion 510 and the second annular portion 520 are spaced apart along a direction from the proximal end to the distal end.

[0053] The first annular portion 510 and the second annular portion 520 form a double seal, wherein the first annular portion 510 is close to the wave crest 411 and the second annular portion 520 is close to the wave trough 412, thereby ensuring the flexibility of the stent graft and ensuring that the stent graft can be compressed into a thinner outer sheath.

[0054] like Figure 3 , Figure 4 and Figure 5 As shown, in an optional embodiment, the coated stent is provided with a window area 600, and the window area 600 is configured as a leak-proof area 200 of leak-proof fabric. The window area 600 can be configured into a circular or diamond shape, and the leak-proof area 200 is made to correspond to the shape of the window area 600. When a window is opened in the coated stent and the branch is released, internal leakage at the overlap position of the branch and the main body can be prevented.

[0055] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 and Figure 7 As shown, the coating support processing method provided by the embodiment of the present invention includes the following steps: weaving a leakproof fabric having a basic area 100 and a leakproof area 200 in an integrally woven manner, and loading a foaming member 300 in the leakproof area 200; connecting the leakproof fabric to the support 400. Among them, the loading method of the foaming member 300 can utilize the gap formed by the woven structure of the leakproof area 200, and when loading the foaming member 300, the foaming material can be inserted into the gap of the woven structure of the leakproof area 200. The shape of the leakproof area 200 can be designed according to the needs of the coating support, and the foaming member 300 can be inserted into the leakproof area 200 after the warp yarn 001 and the weft yarn 002 are woven, or the foaming member 300 can be woven into it during the weaving process of the warp yarn 001 and the weft yarn 002. The coated stent processing method described in this embodiment can be used to form the leak-proof fabric described in the above embodiment, and the leak-proof fabric is sewed to the stent 400 to form a coated stent, which has the technical effects of the above leak-proof fabric and coated stent, and will not be repeated here.

[0056] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A leakproof fabric, characterized in that: The leakage-proof fabric comprises a basic area (100) and a leakage-proof area (200), wherein the basic area (100) and the leakage-proof area (200) are woven together as one body; The anti-leakage area (200) is woven and connected with a foaming piece (300), and the foaming piece (300) has a dehydration shrinkage state and a water absorption expansion state; The leakproof fabric is formed by interweaving a plurality of warp yarns (001) and a plurality of weft yarns (002); In the leakage-proof area (200), the plurality of warp yarns (001) are divided into a base fabric group and a fabric surface group; Each of the warp yarns (001) in the basic fabric group is interwoven with the weft yarns (002) in an up-and-down manner; The plurality of warp yarns (001) in the fabric surface group are evenly distributed along the extension direction of the weft yarns and are respectively extended and interwoven in the base area (100), and the plurality of warp yarns (001) in the fabric surface group cross over the plurality of weft yarns (002) in the leakage prevention area (200) to form floating lines.

2. The leakproof fabric according to claim 1, characterized in that: In the basic area (100), a plurality of the warp yarns (001) and a plurality of the weft yarns (002) are interwoven in an up-and-down manner.

3. The leakproof fabric according to claim 1 or 2, characterized in that: In the extension direction of the weft yarns (002), the foaming member (300) is interwoven between any two adjacent warp yarns (001).

4. A stent graft, characterized in that: include: A support (400) and a coating connected to the support (400), wherein the coating is configured as the leakproof fabric according to any one of claims 1 to 3.

5. The stent graft according to claim 4, characterized in that: The proximal end and the distal end of the stent graft are respectively provided with an annular leak-proof area (500), and the annular leak-proof area (500) is configured as the leak-proof area (200) of the leak-proof fabric.

6. The stent graft according to claim 5, characterized in that: The stent (400) comprises a plurality of corrugated frames (410), wherein the plurality of corrugated frames (410) are arranged at intervals in a direction from the proximal end to the distal end; At least one of the annular anti-leakage areas (500) is located between two adjacent corrugated frames (410) in a direction from the proximal end to the distal end, and / or at least one of the annular anti-leakage areas (500) is located between a wave crest (411) and a wave trough (412) of one of the corrugated frames (410).

7. The stent graft according to claim 5, characterized in that: The support (400) within at least one of the annular leak-proof areas (500) is configured as a non-support structure (401) or a weakly supported structure (402).

8. The stent graft according to claim 5 or 7, characterized in that: The stent (400) comprises a plurality of corrugated frames (410), wherein the plurality of corrugated frames (410) are arranged at intervals in a direction from the proximal end to the distal end; The annular anti-leakage area (500) includes: a first annular portion (510) and a second annular portion (520), wherein the first annular portion (510) and the second annular portion (520) are both surrounded by one of the corrugated frames (410) at the proximal end of the coated stent, and the first annular portion (510) and the second annular portion (520) are spaced apart in a direction from the proximal end to the distal end.

9. The stent graft according to claim 4, characterized in that: The stent graft is provided with a window area (600), and the window area (600) is configured as the leak-proof area (200) of the leak-proof fabric.

10. A method for processing a stent graft, characterized in that: The following steps are involved: A leak-proof fabric having a base area (100) and a leak-proof area (200) is knitted in an integral knitting manner, and a foaming element (300) is loaded in the leak-proof area (200); The leakproof fabric is formed by interweaving a plurality of warp yarns (001) and a plurality of weft yarns (002); in the leakproof area (200), the plurality of warp yarns (001) are divided into a basic fabric group and a fabric surface group; each warp yarn (001) in the basic fabric group is interwoven with the weft yarn (002) in an up-and-down manner; the plurality of warp yarns (001) in the fabric surface group are evenly distributed along the extension direction of the weft yarns, and are respectively extended and interwoven in the basic area (100), and the plurality of warp yarns (001) in the fabric surface group cross over the plurality of weft yarns (002) in the leakproof area (200) to form floating lines; The leakproof fabric is connected to the support (400).

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