A physical sunscreen composition containing Chinese flowering crabapple seed oil, uses thereof, and a sunscreen product

Abstract

The present invention belongs to the field of daily chemicals, and discloses a physical sunscreen composition containing Chinese flowering crabapple seed oil, which comprises 5-25 wt% of zinc oxide and 3-15 wt% of Chinese flowering crabapple seed oil. This composition uses Chinese flowering crabapple seed oil as a physical sunscreen synergist to effectively enhance the sun protection effect of physical sunscreens. At the same time, the present invention also discloses the uses of this composition and sunscreen products.

Description

Technical Field

[0001] The present invention belongs to the daily chemical field, and more specifically, relates to a physical sunscreen composition containing calophyllum inophyllum seed oil, its uses, and sunscreen products. Background Art

[0002] Xianting (Guangzhou) Technology R & D Co., Ltd., the raw material supplier of the present applicant, applied for a patent for invention CN202410453798.9 in 2024, which discloses a sunscreen composition containing calophyllum inophyllum seed oil, its preparation method and applications. It includes the following components in parts by weight: Calophyllum inophyllum seed oil: 0.5 - 25 parts; oil-soluble filter: 0 - 10 parts; oil-soluble UVA filter: 1 - 10 parts; oil-soluble UVB filter: 0.1 - 2 parts; full-spectrum chemical sunscreen: 1 - 8 parts; physical sunscreen: 1 - 8 parts; the oil-soluble filter is butyl methoxydibenzoylmethane and / or ethylhexyl methoxycinnamate.

[0003] The conclusion is that by utilizing the sunscreen synergistic effect of calophyllum inophyllum seed oil and other components, chemical sunscreens with potential safety hazards such as ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane can be replaced or completely substituted. Due to the safety of each sunscreen component or the relatively low dosage required, the safety hazard coefficient is reduced, so as to obtain a sunscreen product with a high sun protection factor, a mild formula, low safety hazards, and even environmental friendliness.

[0004] The mechanism is that calophyllum inophyllum seed oil has strong absorption peaks in the entire ultraviolet band of UVA and UVB. The addition of calophyllum inophyllum seed oil can completely replace or reduce the use of chemical sunscreens, increase the proportion of natural ingredients in the formula, and has a strong sunscreen synergistic effect. On the premise of improving the sun protection value, the safety hazards of the formula are reduced, and even an environmentally friendly and high-sun protection-factor sunscreen product can be obtained.

[0005] Looking at Example 3, Example 4, and Comparative Example 2 of this case, after the dosage of calophyllum inophyllum seed oil reaches 5%, the average SPF synergistic amplitude per part of calophyllum inophyllum seed oil is 1.5; from Example 5, Example 6, and Comparative Example 5 of this case, it can be seen that when the dosage of calophyllum inophyllum seed oil reaches 5%, the average SPF synergistic amplitude per part of calophyllum inophyllum seed oil is almost 0; from Example 3 and Example 7, it can be seen that when calophyllum inophyllum seed oil is present, adding 3% of titanium dioxide, its SPF synergistic amplitude is 2.4 per part of titanium dioxide, and this synergistic amplitude is similar to the efficacy of titanium dioxide used independently. It can be considered that the SPF synergistic effect of calophyllum inophyllum seed oil on inorganic sunscreens is not obvious.

[0006] From this literature, we can consider that using calophyllum inophyllum seed oil alone is effective in enhancing the effect of organic sunscreens at low concentrations; there is no obvious synergistic effect on inorganic sunscreens at low concentrations.

[0007] Compared with chemical sunscreen agents, it is difficult to achieve good sunscreen effects by using pure physical sunscreen agents. In order to enhance the sunscreen effect, in the prior art, most of them are achieved through sunscreen synergists, as follows:

[0008] CN115919667A uses hexagonal boron nitride to enhance the SPF value of zinc oxide sunscreen performance from 30 to 35; this solution is a powder cake, and its synergistic mechanism is unclear.

[0009] CN117959212A uses the antioxidant p-hydroxyacetophenone to enhance zinc oxide and titanium dioxide, and the SPF value is increased from 31 to 46; the mechanism is unclear.

[0010] CN117838564A uses microcrystalline cellulose as a sunscreen synergist for inorganic sunscreen agents. The synergistic mechanism is that the crystal structure of microcrystalline cellulose itself can generate a large amount of light refraction and scattering, prolong the propagation path of light, dissipate light, and at the same time promote the contact between light and the effective sunscreen components, thereby being weakened, promoting the increase of the SPF value and PA value of the product, effectively reducing the use of physical sunscreen powders, and improving the product usability.

[0011] Among the more obvious sunscreen synergists, they achieve sunscreen synergy by prolonging the light propagation path.

[0012] In the records of the solutions for enhancing the sunscreen effect of physical sunscreen agents, it has not been found that Malus prunifolia seed oil can achieve sunscreen synergy.

[0013] Therefore, the technical problem to be solved in this case is: how to effectively enhance the pure physical sunscreen system. Summary of the Invention

[0014] The main purpose of the present invention is to provide a physical sunscreen agent composition containing Malus prunifolia seed oil, which uses Malus prunifolia seed oil as a physical sunscreen synergist to effectively achieve the sunscreen synergy of physical sunscreen agents.

[0015] At the same time, the present invention also discloses the uses and sunscreen products of this composition.

[0016] According to the first aspect of the present invention, there is provided a physical sunscreen agent composition containing Malus prunifolia seed oil, including 5-25 wt% zinc oxide and 3-15 wt% Malus prunifolia seed oil; the median particle size of the zinc oxide is not less than 100 nm.

[0017] In the above composition, the composition is an emulsion system or a cream system.

[0018] In the above composition, the emulsion system or cream system is an oil-in-water system or a water-in-oil system.

[0019] In the above-mentioned composition, an emulsifier is further included; the emulsifier is an oil-in-water emulsifier or a water-in-oil emulsifier.

[0020] In some specific cases, the oil-in-water emulsifier can be one or a combination of more than one of glyceryl stearate / PEG-100 stearate, cetearyl glucoside, cetearyl olivate / sorbitan olivate, C12-20 alkyl glucoside, polyglyceryl-3 methylglucose distearate, and its dosage can generally be 2-5 wt%;

[0021] In some specific cases, the water-in-oil emulsifier can be one or a combination of more than one of cetyl PEG / PPG-10 / 1 dimethicone, dimethicone PEG-10 / 15 crosslinked polymer, PEG-10 dimethicone, PEG-30 dipolyhydroxystearate, sorbitan isostearate, and its dosage can generally be 2-5 wt%;

[0022] In the above-mentioned composition, one or a combination of more than one of polyhydric alcohols, oils and fats, preservatives, chelating agents, pH regulators is further included.

[0023] The polyhydric alcohol can be selected from one or a combination of more than one of glycerol, butanediol, propylene glycol, 1,3-propanediol, 1,2-hexanediol, and its dosage can generally be 5-15 wt%;

[0024] The oil and fat can be selected from one or a combination of more than one of C12-15 alkyl benzoate, isononyl isononanoate, dicaprylyl carbonate, polyhydroxystearic acid, caprylic / capric triglyceride, and its dosage can generally be 10-20 wt%;

[0025] The functions of the polyhydric alcohol are: humectant, stabilizer

[0026] The functions of the oil and fat are: humectant, solvent.

[0027] The preservative, chelating agent, and pH regulator are conventional substances in the art, and their types and dosages can be referred to the relevant usage specifications in cosmetics;

[0028] It is recommended to adjust the pH of the composition to 5.5-7.5.

[0029] Meanwhile, the present invention also discloses the use of the composition as described above in preparing a sunscreen daily chemical product.

[0030] Finally, the present invention also discloses a sunscreen product, including 3-100 wt% of the composition as described above.

[0031] One of the technical solutions in the above technical solutions of the present invention has at least the following advantages or beneficial effects:

[0032] The present invention enhances the sun protection effect of physical sunscreens with Chinese flowering crabapple seed oil, and can increase the SPF value by 4 to 60.

[0033] Its synergistic mechanism is as follows: Chinese flowering crabapple seed oil has significant ultraviolet absorption in the entire ultraviolet wavelength range of 280nm - 420nm. Zinc oxide, as a broad-spectrum sunscreen recognized by the FDA, can prevent ultraviolet rays of 280 - 400nm. Non-nano zinc oxide mainly achieves ultraviolet protection by reflection, but the formed protection network is not dense enough. Combining with Chinese flowering crabapple seed oil with a similar absorption wavelength achieves more efficient ultraviolet protection. Description of the Drawings

[0034] Figure 1 It is the absorbance of Chinese flowering crabapple seed oil under different wavelengths. Detailed Embodiments

[0035] The following details the embodiments of the present invention. The described embodiments are exemplary and are only used to explain the present invention and should not be construed as a limitation of the present invention.

[0036] Description of the raw material sources:

[0037] Chinese flowering crabapple seed oil: Wild virgin organic golden Chinese flowering crabapple oil from Cognis (Guangzhou) Trading Co., Ltd.;

[0038] NAOCOS ASMZP (non-nano zinc oxide): Changzhou Nano New Materials Technology Co., Ltd. According to SEM analysis, the original particle size is greater than 100nm;

[0039] ZnO-C-NJE3 (non-nano zinc oxide): From Kobo Inc. in the United States. According to DLS analysis, the median particle size is 122.72nm

[0040] According to EU SCCS / 1611 / 19, whether it is the original particle size or the secondary particle size, it shows that the median particle size is greater than 100nm. The above materials belong to the non-nano level.

[0041] Nano zinc oxide: SUNZnO-NAS;

[0042] Nano titanium dioxide: STR-I00A-LP.

[0043] The first part: Oil-in-water sunscreen system

[0044] Examples and Comparative Examples

[0045] This part verifies the synergistic effect of Chinese flowering crabapple seed oil in the oil-in-water system.

[0046] The preparation method of the oil-in-water system is as follows:

[0047] Preparation of the aqueous phase: Mix the raw materials of the aqueous phase (polyol, water) in a certain proportion, mix them evenly at an appropriate stirring speed, and heat to above 80 °C to form an aqueous phase for standby after insulation.

[0048] Preparation of the oil phase: Mix the raw materials of the oil phase (inorganic sunscreen agent, Chinese flowering crabapple seed oil, oil), and also mix them evenly at an appropriate homogenization speed, and heat to about 80 °C to form a delicate oil phase.

[0049] Emulsification: Slowly add the oil phase to the aqueous phase while keeping stirring, and then homogenize at high speed to form an emulsion. After the stirring returns to room temperature, add a preservative and a pH regulator.

[0050] The formulation of the oil-in-water system refers to Table 1;

[0051] Table 1 Formulation Table Unit: g

[0052]

[0053]

[0054] In Table 1, the oil is C12-15 alkyl benzoate; the polyol is glycerol; the emulsifier is glyceryl stearate / PEG-100 stearate.

[0055] Performance testing

[0056] The above Examples 1-10 and Comparative Examples 1-9 can all form a stable emulsion system, and their appearances are all similar Figure 1 ;

[0057] Take the above Examples 1-10 and Comparative Examples 1-9 as samples, and test their SPF and PA values;

[0058] The test results are as follows in Table 2:

[0059] Table 2 Test Results

[0060] SPF value PFA value Example 1 23 8 Example 2 69 13 Example 3 52 11 Example 4 27 9 Example 5 65 18 Example 6 26 7 Example 7 63 12 Example 8 47 10 Example 9 26 8 Example 10 60 15 Comparative Example 1 13 6 Comparative Example 2 12 5 Comparative Example 3 17 6 Comparative Example 4 11 2 Comparative Example 5 3 2 Comparative Example 6 18 10 Comparative Example 7 34 10 Comparative Example 8 11 5 Comparative Example 9 26 4

[0061] Result analysis:

[0062] 1. From the test results of Comparative Example 1, Comparative Example 2, Comparative Example 5, Comparative Example 8, and Comparative Example 9, it can be seen that the sun protection value SPF of NAOCOSASMZP is about 1 to 1.1, the sun protection value SPF of ZnO-C-NJE3 is about 1, the sun protection value SPF of nano zinc oxide is about 1.1, and the sun protection value SPF of nano titanium dioxide is about 2.6;

[0063] From Comparative Example 4, it can be seen that the sun protection value SPF of Chinese flowering crabapple seed oil is about 1.1;

[0064] As can be seen from Comparative Example 3, Comparative Example 4, and Comparative Example 5, when 3 g of NAOCOS ASMZP and 10 g of Chinese flowering crabapple seed oil are used in combination, there is a certain synergistic effect, the sun protection factor (SPF) of the sunscreen increases by 3, and the efficacy per gram of NAOCOS ASMZP increases by 1 on average.

[0065] As can be seen from Comparative Example 1, Comparative Example 4, and Example 3, when 12 g of NAOCOS ASMZP and 10 g of Chinese flowering crabapple seed oil are used in combination, there is an obvious synergistic effect, the sun protection factor (SPF) of the sunscreen increases by 28, and the efficacy per gram of NAOCOS ASMZP increases by 2.3 on average.

[0066] As can be seen from Comparative Example 2, Comparative Example 4, and Example 8, when 12 g of ZnO-C-NJE3 and 10 g of Chinese flowering crabapple seed oil are used in combination, there is an obvious synergistic effect, the sun protection factor (SPF) of the sunscreen increases by 24, and the efficacy per gram of ZnO-C-NJE3 increases by 2 on average.

[0067] This shows that when the dosage of non-nano zinc oxide increases to a certain extent, the synergistic efficacy of Chinese flowering crabapple seed oil is further enhanced.

[0068] 2. As can be seen from Comparative Example 6, Comparative Example 7, Comparative Example 8, and Comparative Example 9, in the absence of Chinese flowering crabapple seed oil, the average sun protection factor (SPF) of nano zinc oxide and nano titanium dioxide is 1.1 and 2.6 respectively; in the presence of Chinese flowering crabapple seed oil, the average sun protection factor (SPF) is 0.7 and 2.3 respectively.

[0069] This shows that Chinese flowering crabapple seed oil cannot improve the sun protection performance of nano-scale inorganic sunscreen agents. When the two are combined, it is just the superposition of the sun protection functions.

[0070] As can be seen from Comparative Example 1, Comparative Example 4, Example 3, Comparative Example 2, Comparative Example 4, and Example 8, whether it is NAOCOS ASMZP or ZnO-C-NJE3, Chinese flowering crabapple seed oil has an obvious promoting effect on it.

[0071] The fundamental reason is that non-nano zinc oxide mainly achieves ultraviolet protection by reflection, but the formed protection net is not dense enough. Combining with Chinese flowering crabapple seed oil with a similar absorption wavelength, it achieves more efficient ultraviolet protection.

[0072] While nano-scale zinc oxide or titanium dioxide mainly achieves ultraviolet protection by absorption, and reflection accounts for a very small part. Because the mechanisms are similar, they cannot achieve synergistic enhancement with Chinese flowering crabapple seed oil.

[0073] 3. As can be seen from Examples 1 to 5, when NAOCOS ASMZP is 5, 10, 12, 15, and 25 respectively, its average efficiency is 2.4, 5.25, 3.41, 1.98, and 2.16; the average efficiency of Example 4 is lower than that of Example 3 and Example 5. The possible reason is that the amount of Chinese flowering crabapple seed oil is too small to achieve an obvious synergistic effect;

[0074] From the perspective of comprehensive efficiency, we recommend that the amount of Chinese flowering crabapple seed oil be 5 - 10%, and the amount of NAOCOS ASMZP be 5 - 12%.

[0075] As can be seen from Examples 6 to 10, when ZnO - C - NJE3 is 5, 10, 12, 15, and 25 respectively, its average efficiency is 3, 4.65, 3, 1.51, and 1.96;

[0076] From the perspective of comprehensive efficiency, we recommend that the amount of Chinese flowering crabapple seed oil be 5 - 10%, and the amount of ZnO - C - NJE3 be 5 - 10%.

[0077] The second part is the water - in - oil sunscreen system

[0078] Examples and comparative examples

[0079] This part is to verify the synergistic effect of Chinese flowering crabapple seed oil in the water - in - oil system.

[0080] The preparation method of the water - in - oil system is as follows:

[0081] Prepare the aqueous phase: Mix the aqueous phase raw materials in a certain proportion and mix them evenly at an appropriate stirring speed to form the aqueous phase for standby.

[0082] Prepare the oil phase: Mix the oil phase raw materials, mix them evenly at an appropriate stirring speed, and homogenize them at high speed to form a delicate oil phase.

[0083] Emulsification: Slowly add the aqueous phase to the oil phase while keeping stirring to ensure that the aqueous phase is completely emulsified in the oil phase, and then homogenize it at high speed to form an emulsion.

[0084] The formula of the water - in - oil system refers to Table 3;

[0085] Table 3 Formula table

[0086]

[0087]

[0088] In Table 3, the oil is C12 - 15 alkyl benzoate; the polyol is glycerol; the emulsifier is cetyl PEG / PPG - 10 / 1 polydimethylsiloxane.

[0089] Performance detection

[0090] The above Examples 11 - 20 and Comparative Examples 10 - 12 can all form stable emulsion systems;

[0091] Taking the above Examples 11 - 20 and Comparative Examples 10 - 12 as samples, test their SPF and PA values;

[0092] The test results are shown in Table 4 below:

[0093] Table 4 Test Results

[0094] SPF value PFA value Example 11 29 8 Example 12 86 14 Example 13 62 13 Example 14 27 8 Example 15 73 22 Example 16 24 8 Example 17 81 13 Example 18 58 12 Example 19 30 9 Example 20 65 19 Comparative Example 10 14 6 Comparative Example 11 11 6 Comparative Example 12 10 5

[0095] Result Analysis:

[0096] 1. From Comparative Example 10, Comparative Example 11, and Comparative Example 12, it can be seen that in the water-in-oil system, the average sun protection value SPF of NAOCOSASMZP is about 1.2, the average sun protection value SPF of ZnO-C-NJE3 is about 0.92, and the sun protection value SPF of Malus prunifolia seed oil is about 1;

[0097] From Example 13 and Example 18, it can be seen that in the oil-in-water system, the sun protection values SPF of NAOCOS ASMZP and ZnO-C-NJE3 have both increased significantly.

[0098] 2. From Examples 11 to 15, it can be seen that when NAOCOS ASMZP is 5, 10, 12, 15, and 25 respectively, its average efficacy is 3.8, 7.1, 3.9, 2, and 2.52; from the perspective of comprehensive efficacy, we recommend that the dosage of Malus prunifolia seed oil is 5 - 10%, and the dosage of NAOCOS ASMZP is 5 - 10%.

[0099] From Examples 16 to 20, it can be seen that when ZnO-C-NJE3 is 5, 10, 12, 15, and 25 respectively, its average efficacy is 2.8, 6.6, 4, 1.8, and 2.2;

[0100] From the perspective of comprehensive efficacy, we recommend that the dosage of Malus prunifolia seed oil is 5 - 10%, and the dosage of ZnO-C-NJE3 is 5 - 12%.

Claims

1. A physical sunscreen composition containing Chinese flowering crabapple seed oil, characterized in that, Comprising 5-12 wt% zinc oxide and 10-15 wt% Chinese flowering crabapple seed oil; the median particle size of the zinc oxide is not less than 100 nm, the composition is an emulsion system or a cream system, and the emulsion system or cream system is an oil-in-water system or a water-in-oil system.

2. The composition according to claim 1, wherein Further comprising an emulsifier; the emulsifier is an oil-in-water emulsifier or a water-in-oil emulsifier.

3. The composition according to claim 1, characterized in that, Further comprising one or more combinations of polyols, oils and fats, preservatives, chelating agents, pH regulators.

4. Use of the composition according to claim 1 in the preparation of a sunscreen daily chemical product.

5. A sunscreen product, characterized in that, Comprising 3-100 wt% of the composition according to claim 1.

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