Apparatus and method for three-band light auto-calibration fundus imaging

Abstract

The application discloses a three-waveband light automatic calibration fundus imaging device and method, which comprises a central light path channel, the central light path channel comprising fundus mirrors, a short-wave pass dichroic mirror, an intermediate light path correction module one, a long-wave pass dichroic mirror, an intermediate light path correction module two and an intermediate infrared camera arranged in sequence; further comprising two side infrared cameras at a certain angle with the central light path channel, an annular lamp strip located around the fundus mirror, an induced display located below the long-wave pass dichroic mirror, an OCT sample arm electric control lifting module and an OCT light path channel located directly below the short-wave pass dichroic mirror; the device can obtain face, eye and eyeball gaze direction information, transmit the OCT light beam to the pupil, eliminate the restriction that the human head must be strictly fixed during OCT fundus imaging, suppress the adverse effect of the shaking of the eyeball gaze direction on imaging through visual induction, and automatically adjust the OCT light path spacing, adapt to different vision groups, and improve the efficiency and quality of fundus imaging.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of optical imaging technology, in particular to an OCT fundus imaging device and method related to vision self-correction, human eye induction and human eye automatic calibration. BACKGROUND

[0002] Optical coherence tomography (OCT) can perform high-resolution, non-invasive tomography on biological tissues and materials. Ophthalmic coherence tomography has become the gold standard technology for managing various eye diseases. The desktop OCT system is often used for ophthalmic diagnosis due to its non-contact and high-resolution three-dimensional imaging advantages. However, the desktop design is bulky and requires a professional operator to accurately align the device with the human eye, which limits the application of the desktop OCT system in ophthalmic specialist clinics and ophthalmic imaging rooms. In addition, the desktop OCT also has strict eye examination requirements such as sitting posture, fixing the forehead and chin, and maintaining gaze, so it significantly hinders the routine assessment and diagnosis of eye diseases for patients who cannot cooperate intellectually or physically. The robotic automation of ophthalmic OCT provides a promising solution for obtaining high-quality images and reducing patient cooperation and operational skill requirements. The OCT imaging robot actively aligns and accurately tracks the eye, so that the patient is no longer restricted by the mechanical fixed device during the imaging process. In addition, the OCT imaging robot can replace human operators to avoid motion artifacts caused by operator fatigue or physiological tremor, ensuring accurate alignment during the imaging process. The OCT imaging robot has the potential to completely change the way people care for their eyes. However, the OCT imaging robot must require a shorter working distance when pursuing a wider range of fundus imaging, and it is a challenging problem for the OCT imaging robot to simultaneously ensure accurate alignment of the human eye while imaging the human eye at a short working distance. In addition, people with poor vision have different degrees of myopia or hypermetropia, and it is necessary to automatically match the OCT fundus scan for people with different vision. SUMMARY

[0003] The purpose of the present application is to solve the problem of cooperation between short-distance OCT imaging and accurate alignment of the human eye. The present application provides a three-waveband light automatic calibration fundus imaging device, which is as follows:

[0004] The device for three-waveband light automatic calibration fundus imaging comprises a central light path channel, the central light path channel comprises, in sequence, a fundus mirror, a short-wave-pass dichroic mirror, an intermediate light path correction module one, a long-wave-pass dichroic mirror, an intermediate light path correction module two and an intermediate infrared camera, wherein two side infrared cameras are symmetrically arranged on both sides of the short-wave-pass dichroic mirror, and the two side infrared cameras are placed at a certain angle with the central light path channel and face the front of the fundus mirror; an annular lamp strip is arranged at the front end of the fundus mirror; the plane of the short-wave-pass dichroic mirror and the long-wave-pass dichroic mirror is at an angle of 45° with the light path of other components in the central light path channel. The side infrared cameras are used to capture the images of the face and the eyes, and provide part of the relative position information for aligning the imaging device to the pupil of the eyes at the ideal working distance; the placement positions of the two side cameras need to meet that the field of view obtained by the two side cameras at the working distance can cover the face. The central light path channel is used to transmit the complete image of the eyes and the pupil when aligning the eyes, and is also used to transmit the eye-induced light and the OCT imaging light beam. The specific functions of the components in the central light path channel are as follows: the short-wave-pass dichroic mirror is used to separate the OCT imaging light beam and the eye reflection light, and the long-wave-pass dichroic mirror is used to separate the induced light and the eye reflection light.

[0005] The device further comprises an induced display located below the long-wave-pass dichroic mirror, an OCT sample arm electrically controlled lifting module and an OCT light path channel located directly below the short-wave-pass dichroic mirror; specifically, the OCT light path channel comprises, in sequence from bottom to top, a collimating mirror, a two-dimensional galvanometer system and an OCT light path correction module, and the OCT sample arm electrically controlled lifting module is used to drive the OCT light path channel to move up and down. The induced display is used to induce the line of sight of the eyes. The OCT light path channel is used to control the OCT imaging light beam to become a scanning state and transmit the OCT imaging light beam to the short-wave-pass dichroic mirror of the central light path channel, and finally transmit the OCT imaging light beam to the eyes.

[0006] Preferably, the annular lamp strip specifically comprises a plurality of annularly and uniformly distributed LED lamp beads, and the LED lamp beads emit infrared light with a waveband of 750nm-950nm.

[0007] Specifically, the cut-off waveband of the short-wave-pass dichroic mirror is 950nm, the short-wave-pass dichroic mirror reflects light with a waveband of 950nm or above and transmits light with a waveband of 950nm or below; the cut-off waveband of the long-wave-pass dichroic mirror is 700nm, the long-wave-pass dichroic mirror reflects light with a waveband of 700nm or below and transmits light with a waveband of 700nm or above.

[0008] Specifically, the receiving waveband of the intermediate infrared camera is 750-950nm; the emitting waveband of the induced display is 400nm-700nm; the emitting waveband of the OCT light source is 1010nm-1110nm; and the receiving waveband of the side infrared camera is 750nm-950nm.

[0009] Specifically, the intermediate optical path correction module one, the intermediate optical path correction module two and the OCT optical path correction module are each composed of two achromatic doublet lenses.

[0010] In another aspect, the application also discloses a method for three-waveband light self-calibration fundus imaging, which is based on the above-mentioned three-waveband light automatic calibration fundus imaging device; the method comprises:

[0011] The annular light belt provides 750nm-950nm infrared ambient light for imaging human faces and human eyes and is not easy to be disturbed, and forms an annular point diagram in the pupil of a human eye, which is used to assist the pupil calibration of the intermediate camera.

[0012] The two side infrared cameras are used to acquire human face images and first human eye images, and the three-waveband light automatic calibration fundus imaging device is controlled to reach a preliminary working position according to the human face images and the human eye images; specifically, a mechanical arm is controlled by the device to control the position of the whole device.

[0013] The intermediate infrared camera is used to acquire a second human eye image and an annular point diagram through a central optical path channel, and the three-waveband light automatic calibration fundus imaging device is controlled to reach a final working position according to the second human eye image and the annular point diagram; wherein the second human eye image is formed by infrared ambient light provided by the human eye reflection light belt, and the second human eye image is magnified by the fundus mirror of the central optical path; if the human eye reflection light directly enters the intermediate infrared camera, a high-quality image under an ideal field of view cannot be obtained, therefore, the human eye reflection light passes through the fundus mirror, then passes through a short-wave pass dichroic mirror without influence, then passes through the intermediate optical path correction module one for correcting the light beam, then passes through the intermediate optical path correction module two without influence, and finally is transmitted to the intermediate infrared camera, so that the human eye image under the ideal field of view and the annular light belt point diagram formed in the pupil are obtained.

[0014] The visible light waveband image emitted by the induction display is used to induce the line of sight of the human eye to a specified direction; the visible light emitted by the induction display is reflected into the central optical path channel through the long-wave pass dichroic mirror, then passes through the intermediate optical path correction module one, the short-wave pass dichroic mirror without influence and the fundus mirror in sequence, and finally reaches the human eye to form an image for guiding the human eye. The angle between the long-wave pass dichroic mirror and the central optical path channel and the LED display for inducing the line of sight of the human eye is 45 degrees, the long-wave pass dichroic mirror allows the infrared waveband absorbed by the intermediate infrared camera to pass through, and reflects the visible light emitted by the induction display for inducing the line of sight of the human eye.

[0015] The OCT sample arm electric control lifting module controls the overall up and down movement of the OCT light path to a position matched with the myopia and hypermetropia degree of the measured person according to the vision condition of the measured object, and the OCT light beam is used to scan and image the fundus of the human eye with the ideal working distance. Specifically, the OCT light source with a light-emitting wave band of 1010nm-1110nm emits parallel light beams after collimating mirrors, the parallel light beams are changed into parallel light beams scanning in a two-dimensional plane through a two-dimensional galvanometer system, and then are transmitted to a short-wave-pass dichroic mirror of the central light path after passing through an OCT light path correction module composed of two achromatic doublet lenses; the short-wave-pass dichroic mirror is at an angle of 45 degrees with the central light path and the bottom light path of the OCT, the short-wave-pass dichroic mirror allows the infrared light received by the intermediate infrared camera and the visible light emitted by the induction display for inducing the line of sight of the human eye to pass through, and reflects the OCT imaging light beam. After being reflected by the short-wave-pass dichroic mirror, the light beam is transmitted to the fundus mirror and finally irradiates the human eye pupil to scan the fundus and obtain the fundus scanning image of the human eye.

[0016] After the above scheme is adopted, the beneficial effects of the present application are as follows: the present application designs the combination and separation of the OCT imaging light path and the human eye calibration light path, solves the cooperation problem of short-distance OCT imaging and accurate alignment of the human eye, and introduces another induction light path on the basis of the above two light paths to guide the human eye and assist in accurately imaging the region of interest on the fundus of the human eye, and at the same time, the OCT sample arm electric control lifting module is used to adjust the distance between the OCT light paths according to the myopia or hypermetropia degree of the measured object, so as to meet the automatic OCT fundus imaging of different vision groups.

[0017] In order to make the above-mentioned purposes and features of the present application more obvious and easy to understand, the following preferred embodiments are described in detail below, and the accompanying drawings are used for illustration. BRIEF DESCRIPTION OF DRAWINGS

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiments, and it should be understood that the following drawings only show some embodiments of the present application, and therefore should not be regarded as a limitation on the scope, and for those skilled in the art, other related drawings can also be obtained without creative labor on the basis of these drawings.

[0019] Figure 1 A device structure schematic diagram of the three-waveband light automatic calibration fundus imaging provided by the embodiments of the present application is shown;

[0020] Figure 2 A human face imaging schematic diagram of the double-side infrared camera provided by the embodiments of the present application is shown;

[0021] Figure 3A 16 LED lamp bead ring-shaped lamp strip effect schematic diagram provided by the embodiment of the application is shown.

[0022] Figure 4 A double-side infrared camera initial calibration effect schematic diagram provided by the embodiment of the application is shown.

[0023] Figure 5 An OCT imaging robot structure schematic diagram provided by the embodiment of the application is shown.

[0024] Figure 6 A central light path channel imaging to a human eye schematic diagram provided by the embodiment of the application is shown.

[0025] Figure 7 An induced light transmission to a human eye schematic diagram provided by the embodiment of the application is shown.

[0026] Figure 8 A left eye accurate calibration effect schematic diagram provided by the embodiment of the application is shown.

[0027] Figure 9 An OCT imaging to a fundus under a 50 mm working distance schematic diagram provided by the embodiment of the application is shown.

[0028] Figure 10 A three-waveband light automatic calibration fundus imaging flowchart provided by the embodiment of the application is shown.

[0029] Marked in the figure: 1-funduscope, 2-short wave pass dichroic mirror, 3-intermediate light path correction module one, 4-long wave pass dichroic mirror, 5-intermediate light path correction module two, 6-intermediate infrared camera, 7-induction display, 8-collimating mirror, 9-two-dimensional galvanometer system, 10-OCT light path correction module, 11-OCT sample arm electric control lifting module, 12-side infrared camera, 13-ring-shaped lamp strip, 14-human eye, 15-device control mechanical arm, 16-three-waveband light automatic calibration fundus imaging device. DETAILED DESCRIPTION

[0030] To make the purposes, technical solutions, and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be described below in a clear and complete manner with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some but not all of the embodiments of the present application. The components of the embodiments of the present application described and shown in the drawings can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the claimed present application, but merely represents selected embodiments of the present application. Based on the embodiments of the present application, every other embodiment obtained by a person of ordinary skill in the art without creative work falls within the scope of protection of the present application.

[0031] First, the application scenarios applicable to the present application are introduced. The robot OCT in the present application is an important link for eye fundus scanning imaging of a patient for eye diagnosis and treatment. OCT can detect tiny retinal or optic nerve head lesions, thus providing a sensitive diagnostic means in the early stage of the disease, which is particularly important for early intervention and treatment of eye diseases. For an eye disease that has been diagnosed, OCT scanning can be used to monitor the progress of the disease and evaluate the treatment effect. For example, in the treatment of glaucoma, OCT can help doctors evaluate the changes in the retinal nerve fiber layer thickness, so as to adjust the treatment plan. In ophthalmic surgery, OCT can provide real-time eye structure imaging to help doctors plan and operate the surgery.

[0032] It is found through research that, to implement robot OCT imaging of a large field of view, the key lies in that the OCT robot imaging device needs to realize accurate three-dimensional space point positions and tracking of a pupil and a gaze direction in a working distance range, that is, to automatically implement eye OCT imaging calibration.

[0033] Embodiment 1

[0034] Based on the above content, the embodiments of the present application provide a device for three-waveband light automatic calibration of eye fundus imaging, which solves the coordination problem between OCT robot automatic calibration of a pupil and OCT imaging at a short distance.

[0035] Please refer to Figure 5 , Figure 5 A structure schematic diagram of an OCT imaging robot provided in the embodiments of the present application is shown in FIG. 1. As shown in FIG. 1, the OCT imaging robot includes a robot body 1, a robot arm 2, a robot head 3, a robot hand 4, and an OCT imaging device 5. Figure 5As shown in the figure, the OCT imaging robot structure provided in the embodiment of the present application comprises a device control robot arm 13 and a three-waveband light automatic calibration fundus imaging device 16. The three-waveband light automatic calibration fundus imaging device is used to acquire image information of a human face, human eyes and eyeball gaze directions, and to realize final OCT imaging. The device control robot arm is used to control the device to move to an ideal working position according to the image information of the human face, human eyes and eyeball gaze directions acquired by the three-waveband light automatic calibration fundus imaging device.

[0036] As shown in the figure, Figure 2 , Figure 2 The bilateral infrared camera pair provided in the embodiment of the present application is used for human face imaging. As shown in the figure, Figure 2 As shown in the figure, the three-waveband light automatic calibration fundus imaging device provided in the embodiment of the present application comprises two side infrared cameras 12. The two side infrared cameras 12 can acquire a public field of view of a human face with a width of 100 mm when the imaging distance is 50 mm.

[0037] As shown in the figure, Figure 3 , Figure 3 The annular lamp strip 13 attached around the fundus mirror 1 is provided in the embodiment of the present application. As shown in the figure, Figure 3 The annular lamp strip is composed of 16 infrared LED lamp beads which are uniformly distributed around the fundus mirror. In addition to providing infrared ambient light for the human face, the annular lamp strip also forms an obvious annular point diagram in the human eye 14, which is used to acquire the eyeball gaze direction to assist in pupil calibration.

[0038] As shown in the figure, Figure 4 , Figure 4 The initial calibration effect diagram of the bilateral infrared camera pair provided in the embodiment of the present application is shown in the figure. As shown in the figure, Figure 4 As shown in the figure, the bilateral infrared camera pair provided in the embodiment of the present application can acquire almost the entire human face and the complete image of the double human eyes at the initial calibration position.

[0039] As shown in the figure, Figure 1 , Figure 1 The device structure diagram of the three-waveband light automatic calibration fundus imaging device provided in the embodiment of the present application is shown in the figure. As shown in the figure, Figure 1As shown, the device for three-waveband light automatic calibration fundus imaging of the embodiment comprises a central light path channel, the central light path channel comprises a fundus mirror 1, a short-wave pass dichroic mirror 2, an intermediate light path correction module one 3, a long-wave pass dichroic mirror 4, an intermediate light path correction module two 5, and an intermediate infrared camera 6 arranged in sequence, wherein two side infrared cameras 12 are symmetrically arranged on both sides of the short-wave pass dichroic mirror 2, and the two side infrared cameras 12 are at a certain placement angle with the central light path channel and face the front of the fundus mirror 1; an annular lamp strip 13 is arranged at the front end of the fundus mirror 1; the plane of the short-wave pass dichroic mirror 2 and the long-wave pass dichroic mirror 4 is at an angle of 45° with the light path of other components in the central light path channel. Specifically, the placement angle of the two side infrared cameras 12 with the central light path channel is 25-35 degrees, and the embodiment is 30 degrees.

[0040] The device further comprises an induced display 7 located at the side of the long-wave pass dichroic mirror 4, an OCT sample arm electric control lifting module 11, and an OCT light path channel located below the short-wave pass dichroic mirror 2; the OCT light path channel comprises a collimating mirror 8, a two-dimensional galvanometer system 9, and an OCT light path correction module 10 arranged in sequence from bottom to top, and the OCT sample arm electric control lifting module 11 is used to drive the OCT light path channel to move up and down.

[0041] The focal length of the fundus mirror 1 is 50 mm, which is used for large field OCT fundus scanning at a working distance of 50 mm.

[0042] The short-wave pass dichroic mirror 2 is located at the central position of the two side infrared cameras and also belongs to part of the central light path channel, which is used to transmit the 750nm-950nm infrared light reflected by the induced light and the human eye, and reflect the OCT imaging light beam with a wave band of 1010-1110nm;

[0043] The intermediate light path correction module one is composed of two double-cemented achromatic lenses with a focal length of 75 mm, which is used to transmit the human eye image to the subsequent central light path and transmit the induced image emitted by the induced display.

[0044] The cut-off wave band of the long-wave pass dichroic mirror 4 is 700 nm, which is used to transmit the 750nm-950nm infrared light reflected by the human eye, and reflect the visible light image with a wavelength of 400nm-700nm emitted by the induced display 7 for inducing the visual line of the human eye.

[0045] The intermediate light path correction module two 5 is used to guide the received human eye reflection light to the intermediate infrared camera 6 at a suitable angle and convergence degree.

[0046] The intermediate infrared camera 6 is used to receive the infrared human eye image reflected by the human eye and transmitted by the central light path.

[0047] The inducing display 7 is used to induce the line of sight of the human eye, which emits a 400nm-700nm visible light image to guide the human eye to look in a specified direction.

[0048] The OCT light path channel is used to conduct the OCT imaging light beam.

[0049] Referring to Figure 6 , Figure 6 A central light path channel for imaging the human eye provided by an embodiment of the present application is shown in FIG. 1. As shown in FIG. 1, the human eye 14 is used to provide an information source for OCT robot calibration, Figure 6 The central light path channel for imaging the human eye in the OCT robot calibration system 100 includes: Figure 6 The fundus mirror 1;

[0050] The short-wave pass dichroic mirror 2 with a cutoff wavelength of 950nm is used to transmit the 400nm-700nm inducing light and the 750nm-950nm infrared light reflected by the human eye, while reflecting the OCT imaging light beam with a wavelength of 1010-1110nm;

[0051] The intermediate light path correction module one 3;

[0052] The long-wave pass dichroic mirror 4 with a cutoff wavelength of 700nm is used to transmit the 750nm-950nm infrared light reflected by the human eye, while reflecting the 400nm-700nm visible light image emitted by the inducing display 7 used to induce the line of sight of the human eye;

[0053] The intermediate light path correction module two 5;

[0054] The intermediate infrared camera 6.

[0055] As shown in FIG. 2, the 750nm-950nm ambient light reflected by the human eye 14 passes through the fundus mirror 1, the short-wave pass dichroic mirror 2, the intermediate light path correction module one 3, the long-wave pass dichroic mirror 4 and the intermediate light path correction module two 5 in sequence and finally enters the intermediate infrared camera 6.

[0056] Figure 6 Referring to ,

[0057] An inducing light transmission to the human eye provided by an embodiment of the present application is shown in FIG. 3. As shown in FIG. 3, the 400nm-700nm visible light image emitted by the inducing display 7 used to induce the line of sight of the human eye passes through the long-wave pass dichroic mirror 4 with a cutoff wavelength of 700nm, and then passes through the intermediate light path correction module one 3, the short-wave pass dichroic mirror 2 with a cutoff wavelength of 950nm and the fundus mirror 1 in sequence to be observed by the human eye 14. Figure 7 Figure 7 Figure 7

[0058] Figure 8 Figure 8 ​​​​​A schematic diagram of the precise calibration effect on the left eye provided by an embodiment of the present application is shown in FIG. 1. Figure 8 As shown in FIG. 1, at the final working distance of 50 mm, the two side infrared cameras 12 can obtain the face and eye images, and the middle infrared camera can obtain the eye image.

[0059] Please refer to Figure 9 , Figure 9 A schematic diagram of the OCT imaging of the fundus at a working distance of 50 mm provided by an embodiment of the present application is shown in FIG. 2. Figure 9 As shown in FIG. 2, the OCT light source of 1010 nm-1110 nm is irradiated to the two-dimensional galvanometer system 9 through the collimating mirror 8, and becomes a scanning state with the galvanometer system as the focal point, and then passes through the OCT optical path correction module 10 composed of two achromatic doublet lenses with focal lengths of 80 mm and 150 mm, is reflected into the central optical channel through the short-wave pass dichroic mirror 2 with a cutoff wavelength of 950 nm, passes through the fundus mirror 1, and finally converges at the position of the pupil of the human eye at 50 mm to perform fundus scanning.

[0060] Embodiment 2

[0061] The present embodiment provides a method for three-band light self-calibration fundus imaging, and the device of the method is based on the three-band light self-calibration fundus imaging device of embodiment 1.

[0062] Please refer to Figure 10 , Figure 10 A flowchart of the three-band light automatic calibration fundus imaging process provided by an embodiment of the present application is shown in FIG. 3. Figure 10 As shown in FIG. 3, the three-band light automatic calibration fundus imaging method provided by the present embodiment includes:

[0063] S101, the environment light is provided by the ring light belt 13, and the two side infrared cameras 12 acquire the image information of the face and the eye of the imaging object at the initial position according to imaging similar to Figure 2 .

[0064] S102, the device control mechanical arm 15 calculates the relative position relationship between the head of the imaged person and the device according to the initial information acquired by the two side infrared cameras 12, and starts to control the device to reach the preliminary working position (within 10 mm from the target position) in real time. In this process, the relative position information acquired by the two side infrared cameras 12 and the process of the device control mechanical arm 15 moving according to the relative position information constantly occur.

[0065] S103, the infrared light reflected by the eye and the surrounding part reaches the middle infrared camera 6 through the central optical channel, and the transmission process of the eye image is shown in FIG. 4. Figure 6 As shown in FIG. 4, the middle infrared camera 6 acquires the image information of the eye at the current position and the ring point diagram in the pupil.

[0066] S104, the device controls the mechanical arm 15 to further calculate the relative position relationship between the eye of the imaged person and the device and the gaze direction of the eyeball by using the image of the human eye and the annular point image in the pupil obtained by the intermediate infrared camera 6, and starts to control the device to accurately reach the final working position of 50mm (within 20um from the target position) in real time.

[0067] S105, the visible light image of the induction display 7 for inducing the line of sight of the human eye reaches the human eye through the partial central light path channel, and the human eye is guided to a specified direction through the induction image, so that the gaze direction of the eyeball is inhibited from being shaken adversely, and finally an effect image as shown in Figure 8 is obtained.

[0068] S106, according to the vision condition of the measured object, the OCT sample arm electric control lifting module controls the OCT light path module to move up and down to a position matched with the vision of the measured object, then the OCT imaging light beam enters the pupil to scan the fundus and realize fundus imaging through the OCT light path channel and the partial central light path channel, and the specific transmission process of the light beam is as shown in Figure 9 .

[0069] The positions and angles at which the two side infrared cameras 12 are placed satisfy that the images obtained by the two side infrared cameras 12 can contain the whole human face within the image field of view at the working distance.

[0070] The specific requirement that the images obtained by the two side infrared cameras 12 can contain the whole human face within the image field of view is that most of the image field of view is the human face, and in the embodiment, the distance between the image field of view edge and the human face is 2-3cm.

[0071] The above only describes the preferred embodiments of the present application, and it should be understood that the present application is not limited to the forms disclosed herein, and should not be regarded as excluding other embodiments, but can be used in various other combinations, modifications and environments, and can be modified within the scope of the concepts described herein by the above-mentioned teaching or related technical or knowledge. Any modification and change made by the person skilled in the art without departing from the spirit and scope of the present application shall be within the protection scope of the claims of the present application.

Claims

1. A device for three-wavelength light auto-calibration fundus imaging, characterized in that, The device comprises a central light path channel, the central light path channel comprises, in sequence, an eye fundus mirror (1), a short-wave pass dichroic mirror (2), an intermediate light path correction module one (3), a long-wave pass dichroic mirror (4), an intermediate light path correction module two (5), and an intermediate infrared camera (6), wherein two side infrared cameras (12) are symmetrically arranged on both sides of the short-wave pass dichroic mirror (2), and the two side infrared cameras (12) are at a certain placement angle with the central light path channel and face the front of the eye fundus mirror (1); an annular light belt (13) is arranged at the front end of the eye fundus mirror (1), and the annular light belt (13) can emit infrared light; the plane of the short-wave pass dichroic mirror (2) and the long-wave pass dichroic mirror (4) is at an angle of 45° with the light path of other components in the central light path channel; Further comprising an induction display (7) for inducing the line of sight of the human eye, which is arranged below the long-wave pass dichroic mirror (4); Further comprising an OCT sample arm electric control lifting module (11) and an OCT light path channel arranged below the short-wave pass dichroic mirror (2), the OCT light path channel comprises, in sequence from bottom to top, a collimating mirror (8), a two-dimensional galvanometer system (9), and an OCT light path correction module (10), and the OCT sample arm electric control lifting module (11) is used to drive the OCT light path channel to move up and down.

2. The apparatus for three waveband optical auto-calibration fundus imaging according to claim 1, wherein, The annular light belt (13) is specifically a plurality of annular LED lamp beads which are uniformly distributed.

3. The device for automatic calibration of fundus imaging with three-band light according to claim 2, characterized in that, The LED lamp beads can emit infrared light with a wave band of 750nm-950nm.

4. The apparatus of claim 1, wherein, The short-wave pass dichroic mirror (2) has a cut-off wave band of 950nm, reflects light with a wave band above 950nm, and transmits light with a wave band below 950nm; the long-wave pass dichroic mirror (4) has a cut-off wave band of 700nm, reflects light with a wave band below 700nm, and transmits light with a wave band above 700nm.

5. The apparatus of claim 1, wherein the apparatus is configured to automatically calibrate the three waveband light to the eye of the subject. The receiving wave band of the intermediate infrared camera (6) is 750-950nm, and the emitting wave band of the induction display (7) is 400nm-700nm.

6. The apparatus of claim 1, wherein, The emitting wave band of the OCT light source is 1010nm-1110nm, and the receiving wave band of the side infrared camera (12) is 750nm-950nm.

7. The apparatus of claim 1, wherein the apparatus is configured to automatically calibrate the three waveband light to the eye of the subject. The intermediate light path correction module one (3), the intermediate light path correction module two (5), and the OCT light path correction module (10) are each composed of two achromatic doublet lenses.

8. A method for three-band optical self-calibration fundus imaging, characterized in that, The method is based on the device for automatically calibrating eye fundus imaging of three wave bands of light according to any one of claims 1-7, and the method comprises the following steps: The annular light belt (13) provides an infrared ambient light with a wave band of 750nm-950nm for the human face, so that a ring-shaped point image of the annular light belt is generated in the pupil of the human eye; The human face image and the first human eye image are acquired by the two side infrared cameras (12), and the device for automatically calibrating eye fundus imaging of three wave bands of light is controlled to reach a preliminary working position according to the human face image and the human eye image; The intermediate infrared camera (6) is used to obtain a second human eye image and a ring point image through a central light path channel, and the three-waveband light automatic calibration eye fundus imaging device is controlled to reach a final working position according to the second human eye image and the ring point image; The visible light waveband image emitted by the induced display (7) is used to induce the human eye to look in a specified direction; The OCT sample arm electric control lifting module (11) controls the whole OCT light path channel to move up and down to a position matched with the myopia and hypermetropia degree of the measured object according to the vision condition of the measured object, and the OCT light beam is used to scan and image the eye fundus of the human eye with an ideal working distance.

9. The method of claim 8, wherein, The positions and angles of the two side infrared cameras (12) meet that, at a working distance, the images obtained by the two side infrared cameras (12) can contain the whole human face in a field of view.

Images