Liquid adjustable intraocular lens with suspended center lens

Abstract

An intraocular lens (IOL) has a small central lens suspended within a pliable housing that is coaxially aligned with a second lenslet embedded in a wall of the housing when the housing is filled with a liquid. The suspension is located on a dome-shaped or other-shaped webbing attached to the inner periphery of the wall. When filled with a liquid, the distance between the lenses is adjusted to adjust the focal length, such as the force of the ciliary muscles in the eye that presses or pulls the equator of the housing. An optional haptic may protrude from a point above or below the equator. A recess in the rear hemisphere of the housing is capable of maintaining the growth of the cells away from the optical axis of the lens system. A third lenslet may be embedded in an opposing wall of the housing and coaxially aligned with the other lenses to form a three-lens super zoom system.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the benefit of U.S. Provisional Application No. 63 / 545,254, filed on October 23, 2023, which is hereby incorporated by reference in its entirety for all purposes. Technical Field

[0003] The present disclosure relates to the technical field of ophthalmic medical devices, and more particularly, to a liquid-accommodative intraocular lens having a lens suspended at its center, the lens suspended at its center being aligned with one or more other lenses embedded in its wall. Background Art

[0004] Cataract extraction combined with intraocular lens (IOL) implantation is still one of the only effective cataract treatments at present and in the future. Although traditional monofocal IOL implantation after cataract surgery can achieve good long-distance vision, monofocal IOLs do not have the ability to adjust the focal length. After surgery, patients generally have hyperopia and need to rely on glasses to meet the requirements of different close-up work.

[0005] Multifocal intraocular lenses use a unique optical design that can form two or more focal points in the eye at the same time. After surgery, patients can adjust the size of their pupils and choose different focal points to meet the needs of farsightedness and nearsightedness, which reduces the rate of cataract patients wearing glasses after surgery. However, when there are multiple focal points, they can cause halos, glare and other disadvantages to patients.

[0006] In recent years, some scholars have attempted to design an adjustable intraocular lens by changing the filling amount of the optical fluid medium (such as silicone oil) in the capsular bag or changing the type of the optical fluid medium.

[0007] There is a need in the art for improved intraocular lenses that are capable of being adjusted, preferably by the patient's own ciliary muscles. Summary of the invention

[0008] Generally described is a fluid-fillable intraocular lens device similar to a soft-sided bag, having multiple precision rigid optical lenses within, one lens suspended at its center by webbing. Another or more optical lenses are on the bag wall and aligned coaxially with the central lens. When the soft-sided bag is squeezed or pulled around its periphery, such as by the eye's ciliary muscles, the lenses move axially relative to each other, thereby changing the device's diopter.

[0009] The device may be made of two halves joined together with the seam not being at the equator. The haptic arms may extend from the equator, or from regions on either side of the equator but not on the equator.

[0010] Since the webbing and central lens divide the device into two halves internally, the device can be considered to have two chambers: an anterior chamber and a posterior chamber. This dual chamber device is able to adjust the optical path of the entire intraocular lens device, thereby enabling sufficient changes in focus.

[0011] Some embodiments of the present invention relate to an adjustable intraocular lens device, comprising: a flexible liquid-fillable shell having an equator defined by a periphery of the shell farthest from the optical axis of the shell; a sealable valve in the shell; an elastic webbing extending from the inner periphery of the shell; a central lens suspended at the center of the shell by the webbing; and a second lens disposed within the wall of the shell, wherein, when the shell is filled with liquid: the central lens is coaxial with the second lens, and radial pulling or pushing on the equator changes the distance between the lenses while keeping the lenses coaxial.

[0012] The elastic webbing may be curved in a direction parallel to the optical axis, similar to a dome. The elastic webbing may include a plurality of different curved arms, or may include a membrane ring having an opening therein. A seam may be formed by two halves of a flexible shell, wherein the seam is neither disposed at the equator nor intersecting the equator. A recess may be formed in the shell, the recess having a continuous edge disposed about the optical axis, the continuous edge configured to seal the encapsulated bag when implanted. When the shell is filled with liquid, the highest point in the recess may be lower than the continuous edge, and the recess is configured to keep the encapsulated bag away from the shell wall material within the recess.

[0013] A third lens may be disposed in a wall of the housing opposite to the second lens, wherein when the housing is filled with liquid: radial pulling or pushing on the equator changes the distance between the central lens and the third lens while keeping the first lens, the second lens and the third lens coaxial.

[0014] The device may also include a set of haptic arms that protrude from an area on the housing that is or is not on the equator of the housing. The set of haptic arms may be referred to as a first set of haptic arms, and the device may also include a second set of haptic arms that protrude from an area on the housing that is on a hemisphere of the equator opposite to the first set of haptic arms. The ends of the first haptic arm and the second haptic arm may be joined together.

[0015] The sealable valve may include a ring and a self-sealing polymer body surrounded by the ring, the polymer body being softer than the ring. A layer of parylene may be laid over the sealable valve. The central lens or one or more other lenses may be formed of polymethyl methacrylate (PMMA), silicone, siloxane, fluorosilane or hydrophobic acrylate. A liquid such as silicone oil may fill the liquid-fillable flexible shell.

[0016] Some embodiments relate to a method for manufacturing and testing an accommodative intraocular lens, the method comprising: connecting a center lens to an elastic webbing extending from an inner periphery of a first half of a flexible shell; joining a second half of the flexible shell to the first half to form a flexible liquid-fillable shell having an equator defined by a periphery of the shell farthest from an optical axis of the shell; filling the shell with liquid through a sealable valve to coaxially align the center lens with a second lens disposed within a wall of the shell; and squeezing the equator of the liquid-filled shell to increase the distance between the center lens and the second lens while keeping the lenses coaxial.

[0017] The joining may include adding an uncured polymer on the halves to form a seam, wherein the seam is neither disposed at nor intersecting the equator. The method may also include joining an end of a first haptic arm protruding from a point on the housing that is not on the equator to an end of a second haptic arm protruding from a point on the housing that is on a hemisphere of the equator opposite the first haptic arm. It may also include folding or rolling the housing in preparation for implantation.

[0018] Some embodiments relate to a liquid-adjustable intraocular lens with a dual chamber, comprising: a capsule, in which a chamber is formed, the capsule comprising: a front capsule; and a posterior capsule, the front capsule and the posterior capsule are fluidically connected; a sealable valve disposed on the capsule; a membrane layer, which is disposed in the chamber to divide the chamber into a front chamber and a posterior chamber, the front chamber and the posterior chamber are fluidically connected; and a central optical lens formed on the membrane layer and having a preset optical focal length; wherein the central optical lens is formed in the middle of the membrane layer. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 is a perspective view of an accommodating intraocular lens device without haptics according to one embodiment.

[0020] Figure 2 is a cross-sectional view of a dual-lens intraocular lens device according to one embodiment.

[0021] Figure 3A is a cross-sectional view of a device pulled at its equator according to one embodiment.

[0022] Figure 3B According to an embodiment Figure 3A A cross-sectional view of a device at rest.

[0023] Figure 3C According to an embodiment Figure 3A A cross-sectional view of a device squeezed at its equator.

[0024] Figure 4 is a radial cross-sectional view of a device showing a webbing with a plurality of different bending arms according to one embodiment.

[0025] Figure 5 is a radial cross-sectional view showing a device that is a webbing with a membrane ring having holes according to one embodiment.

[0026] Figure 6 is a cross-sectional view of a three-lens intraocular lens device according to one embodiment.

[0027] Fig. 7A is a perspective exploded view of two halves (anterior and posterior capsule) of a device having haptics according to one embodiment.

[0028] Figure 7B yes Fig. 7A A perspective view of the two halves of a device being joined.

[0029] Figure 8 is a flow chart illustrating a process according to one embodiment. DETAILED DESCRIPTION

[0030] An accommodative intraocular lens device is described that has multiple smaller lenses within the device that are capable of moving relative to each other in response to contraction or dilation of the patient's ciliary muscles. A central lens is suspended in the middle of the device from a thin dome-shaped webbing that maintains its tension and shape. The central lens and one or more other lenses are coaxially aligned with each other (at least when a fluid fills the device), and when moved, the central lens and the other lenses remain more or less axially aligned.

[0031] "Bisection" includes division into two parts, or other forms as known in the art. The two parts are not necessarily equal parts.

[0032] A "half" of a device refers to a portion of a device when the device is divided into or composed of two parts, or otherwise as known in the art. A half is not necessarily anywhere near the exact half of an object, but is a substantial portion of a device.

[0033] The "perimeter" of a three-dimensional object includes the perimeter of a circle, ellipse or other closed shape around a central axis as seen from a cross-sectional view of the object, or other forms as known in the art. It does not necessarily mean the maximum perimeter of the object.

[0034] The "equator" of a three-dimensional object includes the greatest circumference of the object, or as otherwise known in the art.

[0035] Figure 11 is a perspective view of an accommodative intraocular lens device 100. It consists of a liquid-fillable shell 102 made of a flexible polymer such as silicone and filled with liquid silicone as shown. The shell or capsule is circular around an optical axis 106 and has an equator 104 defined by an outer periphery farthest from the optical axis.

[0036] A sealable valve 108, sometimes referred to as a sealing valve, is provided on the mostly visible front half of the device. This allows the ophthalmologist to perform filling or adjustment. Shown on the opposite side of the axis, but on the same hemisphere, is a second sealable valve.

[0037] Also visible on the front half is a second lens 110, which is mounted in the wall of the housing. The second lens 110 is a precisely manufactured rigid lens with a preset optical power.

[0038] Figure 2 yes Figure 1 A cross-sectional view of an intraocular lens device. In the housing 102, Figure 1 The second lens 110 visible in FIG. 1 is embedded in the flexible wall 218. The wall 218 surrounds the entire device. The outer periphery 214 of the wall is located on the outside of the device, wherein the largest outer periphery 214 is marked as the device equator 104. At the same time, the inner periphery 216 is located on the inner side of the wall 218 facing the filling liquid 234.

[0039] Liquid 234 is injected through the sealable valve 108. The sealable valve 108 includes a hard polymer ring 232, sometimes referred to as a toroidal body, disposed on the front half 264. The ring 232 surrounds a self-sealing polymer body 230 having a Shore hardness less than that of the ring.

[0040] The valve body is preferably circular and the ring is preferably a circular ring. When the optical fluid medium is injected from the sealable valve 108, since the hardness of the body is less than that of the surrounding ring, it locally adapts to the injection needle entering the capsule 102. In addition, with a soft body, it is easier to achieve sealing after the injection needle is withdrawn to prevent leakage of the optical fluid medium. The ring can be made of hard silicone and the valve body can be made of soft silicone.

[0041] The parylene layer 228 covers the outer surface of the sealable valve 108 and also partially overlaps the outer surface of the bladder 102. This overlap increases the contact area of ​​the parylene layer 228 and the sealable valve 108 for adhesion and helps avoid potential stress concentrations at the interface of the sealable valve 108 and the bladder 102.

[0042] The Young's modulus and hardness of the polyparaxylene layer 228 are significantly higher than those of the sealable valve 108, and the adhesion between the polyparaxylene layer 228 and the sealable valve 108 is better, which is equivalent to making a reinforced baffle layer outside the sealing valve. Therefore, when the injection needle is withdrawn, the optical fluid medium (such as silicone oil) in the sealing valve can generate an outward pressure on the sealing valve, and the outward pressure can make the sealing valve self-closed under the protection of the rigid polyparaxylene layer, so that it can play a role of sealing and leak prevention for a long time.

[0043] In the exemplary embodiment of the figure, two sealable valves 108 are symmetrically arranged on the central axis of the capsule 102. One of the sealable valves can be used for injection, while the other sealable valve plays a role of mechanical compensation and balance, and it can also be used as a backup valve. Other numbers of sealable valves can be used.

[0044] The optical fluid medium 234 can be silicone oil, silane, sterile heavy water for ophthalmology (perfluorodecalin C10F18), sodium hyaluronate (healon GV), or other liquids. The housing can also be pre-filled. During surgery, the liquid can be adjusted until the set shape or optical path is met.

[0045] An elastic webbing 226 extends from the inner periphery 216 of the flexible housing 102 to suspend the central lens 220. The webbing 226 is slightly curved in a direction parallel to the optical axis 106, and is a three-dimensional dome-shaped product of the webbing. The central lens 220 is coaxially aligned with the second lens 110.

[0046] The second lens 110 has a lens center 212 and the center lens 220 has a lens center 222. When forces push radially (up and down in the figure) on the equator 104 or other outer periphery 214 of the housing 102, they are transmitted through the filling structure to change the distance between the lens centers 212 and 222 while keeping the lenses 110 and 220 coaxial. As a result, the lens changes its final focus and zoom.

[0047] During manufacturing, the housing 102 is assembled from two halves, a front half 264 and a rear half 268. The two halves are joined at a seam 236. The seam 236 runs all the way around the housing 102, but is neither located at nor intersecting the equator 104. Further, the polymer 238 added to seal and form the seam has now solidified, which is neither located at nor intersecting the equator 104. Avoiding the equator with a slightly thicker seam allows the equator to more consistently carry and transfer the stresses that move the lenses relative to each other.

[0048] A circular depression 240 is formed in the rear portion 268 of the housing 102. The depression 240 has a continuous edge 242 around it and the optical axis 106. The continuous edge 242 avoids localized dimples or other features so that the edge can seal against the capsular bag when the housing 102 is implanted in a subject.

[0049] One technical advantage of this seal is that it helps prevent cells from growing and migrating over time along the shell from the outer regions to the middle where they could obscure vision around the optical axis.

[0050] As shown in the figure, the continuous edge 242 is higher than the highest point 244 in the recess 240. That is, any line from edge to edge will not touch any part of the recess in the edge. This configuration keeps the enclosed bladder away from the wall 218 of the housing 102.

[0051] One technical advantage of keeping the wall away from the capsular bag is that it allows a surgical laser to be used to precisely cut the posterior portion of the capsular bag without localizing its thermal energy on the capsular bag and melting one side of the shell.

[0052] FIG. 3A to FIG. 3C is a cross-sectional view of a liquid filled intraocular device having a housing 302. Mounted in the wall of the housing 302 is a second lens 310. Suspended within the housing 302 is a center lens 320. The distance between the respective centers of the lenses is shown in the figure.

[0053] exist Figure 3A In the embodiment of the present invention, the equator is pulled by the ciliary muscle or the test fixture, resulting in a relatively short distance 350 between the centers of the lenses.

[0054] exist Figure 3B In the embodiment of FIG. 3 , the housing is at rest with no pulling or pushing forces on its equator, resulting in a longer “resting” distance 352 between the centers of the lenses.

[0055] exist Figure 3C , the equator is squeezed, resulting in a relatively long distance 354 between the centers of the lenses.

[0056] The design allows the same radial forces that affect focus in the natural lens to also affect focus in this multi-microlens device. If calibrated correctly, in some cases the patient doesn't even need glasses. The central lens is suspended on a dome-shaped webbing that enables the lens to move correctly inside and change its focus.

[0057] Figure 4 and Figure 5 Shown are different types of webbing that can be used to suspend the center lens.

[0058] exist Figure 44, a plurality of distinct curved arms 456 extend from the inner periphery 416 of the housing 402. These arms may be calibrated to be relatively thick compared to wider arms or a more continuous dome of material.

[0059] exist Figure 5 In the embodiment of the present invention, a ring of membrane 558 having holes 562 extends from the inner periphery 516 of the housing 502. The membrane 558 is a thin film layer that may or may not be formed separately from the rest of the half. The thickness of the membrane and / or the size of the holes can be calibrated to move the central lens more or less depending on the radial force projected onto the periphery.

[0060] Figure 6 6 is a cross-sectional view of a three-lens intraocular lens device. A flexible housing 602 encapsulates a central lens 620, which is suspended on an internal webbing. The central lens 620 has a lens center 622. A second lens 610 is embedded in its front half and has a lens center 612.

[0061] The third lens 660 is disposed in a wall on the hemisphere opposite to the second lens of the housing 602. Since the second lens is embedded in the front half, the third lens is embedded in the rear half. The third lens 660 has a lens center 666.

[0062] When the housing 602 is filled with liquid, the central lens 620, the second lens 610, and the third lens 660 are coaxially aligned along the optical axis 606 of the housing 602. Pulling or pushing radially on the equator of the housing 602 changes the distance 650 between the central lens 620 and the second lens 610. It can also change the distance 651 between the central lens 620 and the third lens 660. The distances 650 and 651 are all changed while keeping the lenses coaxially aligned.

[0063] One technical advantage of a three-lens system is that it allows for higher optical powers. In addition, there are more ways to calibrate the lenses and more adjustments. This is particularly beneficial for subjects with damage to the ciliary muscles or other natural eye parts.

[0064] FIG. 7A to FIG. 7Bis a perspective view of a device having haptics 770 and haptics 772, where haptics 770 and haptics 772 originate from front half 764 and back half 768, respectively. Like the haptics in other ocular devices, the haptics support devices in the lens capsule that are associated with the action of the ciliary muscles and adjust the shape of the capsule. The haptics can also be sutured directly into the wall of the eye where the ciliary body is located and can be used in the absence of a capsular bag or when the capsular bag is damaged. The haptics can be made of polyvinylidene fluoride (PVDF), polymethyl methacrylate (PMMA), polyimide, acrylate, or other elastic biocompatible material.

[0065] Fig. 7A The half before joining is shown, where the front portion 764 has the largest width perimeter, i.e., the equator 704. At point 771 on the front portion 764, the haptic front connecting arm 770 is connected to its outer surface. The point is approximately between the seam and the pole of the hemispherical half 764, i.e., at halfway through the thickness of the front half 764. A second connecting arm 770 in the same set of haptic arms is disposed on the opposite side of the same hemisphere.

[0066] Similarly, on the back half 768, the haptic front connecting arm 772 connects to the outer surface of the back half at point 774. Point 774 is approximately between the seam and the pole of the hemispherical half 768, i.e., halfway through the thickness of the back half 768. A second connecting arm 772 in the same second set of haptic arms is disposed on the opposite side of the same hemisphere.

[0067] At this point, the ends 776 of the haptic arms 770 and 772 are free. The haptic arms can remain free while the two hemispheres, the front half 764 and the back half 768, are joined together. Alternatively, each haptic arm can be paired with its corresponding arm on the opposite hemisphere.

[0068] Figure 7B Shown are front half 764 and back half 768 joined together at seam 738. In this exemplary embodiment, the ends of the haptic arms are angled and joined together to form a Y-shaped structure with joined ends 778. They can be bonded with an adhesive such as silicone.

[0069] A technical advantage of this configuration where the front connecting arm is connected to the rear connecting arm at its end is that the arms avoid the seam 738 between the halves and avoid the equator 704. It has been demonstrated through mechanical simulation analysis and experiments that the optimal force position for the connection position of the haptic can be found. The split Y design can facilitate force balance of the capsule in diopter adjustment. It can also achieve controllable deformation, thereby improving the accuracy and effectiveness of diopter adjustment.

[0070] Figure 8 8 is a flow chart illustrating a process 800 according to one embodiment. In operation 801, a central rigid lens is connected to an elastic webbing extending from an inner periphery of a first half of a flexible shell. In operation 802, a second half of the flexible shell is joined to the first half to form a liquid-fillable, flexible shell having an equator defined by a periphery of the shell that is farthest from the optical axis of the shell. In operation 803, the end of a first haptic arm protruding from a point on the shell that is not on the equator is joined to the end of a second haptic arm protruding from a point on the shell on the hemisphere opposite the equator to the first haptic arm. In operation 804, the shell is filled with liquid through a sealable valve to align the central rigid lens coaxially with a second rigid lens disposed within the wall of the shell. In operation 805, the equator of the liquid-filled shell is squeezed to increase the distance between the central rigid lens and the second rigid lens while keeping the lenses coaxial. This can be done in testing, or during or after implantation.

[0071] Although what is considered to be the best mode and / or other examples have been described above, it should be understood that various modifications may be made therein, the subject matter disclosed herein may be implemented in various forms and examples, and its teachings may be applied in many applications, only some of which are described herein. The following claims are intended to claim any and all applications, modifications and variations that fall within the true scope of the present teachings.

[0072] Unless otherwise indicated, all measurements, values, ratings, positions, amplitudes, dimensions and other specifications stated in this specification, including those in the appended claims, are approximate and not exact. They are intended to have a reasonable range consistent with the functions to which they relate and the customary practices in the fields to which they belong. For temperature or other engineering units, "about" includes measurements or settings within ±1%, ±2%, ±5%, ±10%, or other tolerance ranges of the specified engineering units as known in the art.

[0073] The scope of protection is limited only by the claims appended hereto. That scope is intended and should be interpreted to be consistent with the ordinary meaning of the language used in the claims when interpreted in light of this specification and subsequent litigation history, and to encompass all structural and functional equivalents.

[0074] Unless stated above, nothing stated or illustrated is intended or should be construed as causing any component, step, feature, object, benefit, advantage or equivalent to be dedicated to the public, whether or not it is recited in the claims.

[0075] It should be understood that the terms and expressions used herein have the same ordinary meanings assigned to them by their respective fields of inquiry and research, except where specific meanings are otherwise provided herein. Relational terms such as first and second may be used only to distinguish one entity or action from another entity or action, without necessarily requiring or implying any actual such relationship or order between such entities or actions. The terms "include", "comprises", or any other variant thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or device that includes a list of elements includes not only those elements, but may include other elements that are not explicitly listed or inherent to such process, method, article, or device. In the absence of further constraints, an element after "a" or "an" does not exclude the presence of additional identical elements in the process, method, article, or device that includes the element.

[0076] The abstract is provided to allow the reader to quickly ascertain the nature of the technical disclosure. It should be understood that it will not be used to interpret or limit the scope or meaning of the claims. In addition, in the foregoing detailed description, it can be seen that various features are combined together in various embodiments for the purpose of streamlining the disclosure. This disclosed method should not be interpreted as reflecting the following intention: the claimed embodiments require more features than those expressly recited in each claim. On the contrary, as reflected in the attached claims, the inventive subject matter lies in less than all the features of a single disclosed embodiment. Therefore, the attached claims are hereby incorporated into the detailed description, with each claim independently serving as a separate claimed embodiment.

Claims

1. An adjustable intraocular lens device, comprising: a flexible liquid-fillable shell having an equator defined by a peripheral edge of the shell farthest from an optical axis of the shell; a sealable valve in said housing; an elastic webbing extending from an inner periphery of the shell; a central lens suspended from the center of the housing by the webbing; and a second lens disposed within a wall of the housing, Wherein, when the housing is filled with liquid: The central lens is coaxial with the second lens, and Radially pulling or pushing on the equator changes the distance between the lenses while keeping the lenses coaxial.

2. The device according to claim 1, wherein: The elastic ribbon is arc-shaped along a direction parallel to the optical axis.

3. The device according to claim 1, wherein: The elastic webbing includes a plurality of different curved arms.

4. The device according to claim 1, wherein: The elastic webbing includes a membrane ring having openings therein.

5. The apparatus according to claim 1, further comprising: A seam is formed by two halves of the flexible shell, wherein the seam is neither disposed at the equator nor intersects the equator.

6. The apparatus according to claim 1, further comprising: a recessed portion formed in the housing, the recessed portion having a continuous edge disposed around the optical axis, The continuous edge is configured to seal the encapsulated pocket upon implantation.

7. The device according to claim 6, wherein: When the housing is filled with liquid, the highest point in the recess is lower than the continuous edge. The recess is configured to retain the encased bladder away from shell wall material within the recess.

8. The apparatus according to claim 1, further comprising: a third lens disposed in a wall of the housing opposite to the second lens; Wherein, when the housing is filled with liquid: Radially pulling or pushing on the equator changes the distance between the central lens and the third lens while keeping the first lens, the second lens and the third lens coaxial.

9. The apparatus according to claim 1, further comprising: A set of haptic arms protrude from areas of the housing that are not on the equator of the housing.

10. The device according to claim 9, wherein: The set of tactile arms is a first set of tactile arms, and the device further comprises: A second set of haptic arms protrude from an area of ​​the housing on a hemisphere of the equator opposite the first set of haptic arms.

11. The device according to claim 10, wherein: Distal ends of the first haptic arm and the second haptic arm are connected together.

12. The device according to claim 1, wherein: The sealable valve comprises: Ring; and A self-sealing polymer body is surrounded by the ring, the polymer body being more flexible than the ring.

13. The apparatus according to claim 1, further comprising: A parylene layer is over the sealable valve.

14. The device according to claim 1, wherein: The central lens is formed of polymethyl methacrylate (PMMA), silicone, siloxane, fluorosilane, or hydrophobic acrylate.

15. The apparatus according to claim 1, further comprising: A liquid fills the liquid-fillable flexible shell.

16. A method of manufacturing and testing an accommodating intraocular lens, the method comprising: connecting the central lens to an elastic webbing extending from an inner periphery of the first half of the flexible housing; joining a second half of the flexible housing to the first half to form a liquid-fillable flexible housing having an equator defined by a peripheral edge of the housing farthest from an optical axis of the housing; filling the housing with a liquid through a sealable valve to coaxially align the central lens with a second lens disposed within a wall of the housing; as well as The equator of the liquid-filled housing is compressed to increase the distance between the central lens and the second lens while keeping the lenses coaxial.

17. The method according to claim 16, wherein: The joining includes adding uncured polymer to the halves to form a seam, wherein the seam is neither disposed at nor intersecting the equator.

18. The method according to claim 16, further comprising: A distal end of a first haptic arm protruding from a point on the housing that is not on the equator is coupled to a distal end of a second haptic arm protruding from a point on the housing that is on a hemisphere of the equator opposite the first haptic arm.

19. The method according to claim 16, further comprising: The housing is folded or rolled in preparation for implantation.

20. A liquid-accommodative intraocular lens having two chambers, comprising: A capsule having a chamber formed therein, the capsule comprising: anterior capsule; and a posterior capsule, the anterior capsule being fluidly connected to the posterior capsule; a sealable valve disposed on the bladder; a membrane layer disposed in the chamber to divide the chamber into a front chamber and a rear chamber, the front chamber and the rear chamber being fluidically connected; and A central optical lens, which is formed on the film layer and has a preset optical power; Wherein, the central optical lens is formed in the middle of the film layer.

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