A sanitary insecticide composition containing ciprofloxacin and propoxur and its application

Abstract

The invention discloses a sanitary insecticidal composition containing ciprofloxacin and propoxur and its application, wherein the active ingredients are ciprofloxacin and propoxur, and the total content of the two is 2%-70%, and the balance is an adjuvant; the weight ratio of the described ciprofloxacin and propoxur is 15:1~1:15; the described sanitary insecticidal composition, the formulation is a suspension concentrate, an oil suspension concentrate, a dry suspension concentrate, a wettable powder and a water dispersible granule. The sanitary insecticidal composition in the present invention has good environmental compatibility on the one hand, reduces the amount of pesticide used, and on the other hand, from the perspective of the mechanism of action, the mechanism of action of ciprofloxacin and propoxur is different, there is no cross-resistance, and the preventive effect is improved. The compounding of the insecticides with different mechanisms of action can also delay pest resistance, which is conducive to the resistance management of pests.

Description

Technical Field

[0001] The invention relates to a binary sanitary insecticide composition and application thereof, in particular to a sanitary insecticide composition containing ciprofloxacin and propoxur and application thereof, wherein the active ingredients of the composition are ciprofloxacin and propoxur. Background Art

[0002] For a long time, the residual spraying agents used for public health pests have mostly been single or compound pyrethroid products. The long-term use of pyrethroid agents has caused health pests such as mosquitoes, flies, and cockroaches to develop varying degrees of resistance to some pyrethroids, greatly reducing the prevention and control effect.

[0003] Cyprodinil is a diamide compound that acts on the nicotinic acetylcholine receptors of insects, interfering with the stimulation conduction of the insect nervous system, thereby causing paralysis and death of the insects.

[0004] Propoxur has contact and stomach poisoning effects with good knockdown activity. It has the dual properties of inhibiting acetylcholinesterase and acting on nerve axons.

[0005] The present invention has found through experiments that a combination of ciprofloxacin and propoxur can solve the resistance problem. On the one hand, from the perspective of the mechanism of action, since the combination of the two does not have cross-resistance with existing sanitary insecticides, the resistance problem of sanitary pests such as mosquitoes, flies and cockroaches is solved, the prevention effect is improved, and the dosage of the medicine is reduced; on the other hand, ciprofloxacin and propoxur have low irritation, which improves the safety of the applicators; and furthermore, the combination of the two insecticides with different mechanisms of action can also delay the development of pest resistance. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to address the deficiencies in the prior art and to provide a sanitary insecticide composition containing ciprofloxacin and propoxur and its application. The active ingredients are ciprofloxacin and propoxur. On the one hand, the composition has good environmental compatibility and reduces the amount of pesticide used. On the other hand, from the perspective of the mechanism of action, ciprofloxacin and propoxur have different mechanisms of action, no cross-resistance exists, and the control effect is improved. The combination of the two insecticides with different mechanisms of action can also delay the development of pest resistance, which is beneficial to the resistance control of pests.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] The invention first provides a sanitary insecticide composition containing ciprofloxacin and propoxur. The active ingredients are ciprofloxacin and propoxur. By weight, the total weight of the active ingredients accounts for 2%-70% of the total weight of the sanitary insecticide composition, and the balance is adjuvants. The weight ratio of ciprofloxacin to propoxur is 15:1-1:15.

[0009] In the above technical solution, the weight ratio of ciprofloxacin to propoxur is preferably 11:1 to 5:1.

[0010] In the above technical solution, the auxiliary agent is a mixture of three or more of a wetting agent, a dispersant, an antifreeze agent, a preservative, a defoaming agent, a thickener, a disintegrant, an emulsifier, a filler, a solvent and deionized water in any proportion.

[0011] In the above technical solution, the sanitary insecticide composition has the dosage form of suspension concentrate, oil suspension concentrate, dry suspension concentrate, wettable powder and water dispersible granules.

[0012] In the above technical solution, when the sanitary insecticide composition is in the form of a suspension, it comprises the following raw materials in weight percentage: 1-40% of ciprofloxacin, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 3-7% of an antifreeze agent, 0.3-2% of a preservative, 0.1-1% of a defoaming agent, 0.5-3% of a thickener, and deionized water is added to make up to 100%.

[0013] In the above technical solution, when the sanitary insecticide composition is in the form of an oil suspension, it comprises the following raw materials in weight percentage: 1-25% of cyfluthrin, 1-10% of propoxur, 0.2-1% of a wetting agent, 0.3-3% of a dispersant, 2-6% of an emulsifier, 0.2-5% of a defoamer, and 0.2-5% of a thickener, with the solvent making up to 100%.

[0014] In the above technical solution, when the sanitary insecticide composition is in the form of a dry suspension, it comprises the following raw materials in weight percentage: 1-50% of cyflumizone, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, and the filler is supplemented to 100%.

[0015] In the above technical solution, when the sanitary insecticide composition is in the form of a wettable powder, it comprises the following raw materials in weight percentage: 1-60% of cyflumizone, 1-10% of propoxur, 2-6% of a wetting agent, 7-18% of a dispersant, and the filler is supplemented to 100%.

[0016] In the above technical solution, when the sanitary insecticide composition is in the form of water-dispersible granules, it comprises the following raw materials in weight percentage: 1-60% of ciprofloxacin, 1-10% of propoxur, 2-15% of wetting agent, 5-20% of dispersant, 2-8% of disintegrant, and the filler is supplemented to 100%.

[0017] In the above technical solution, the wetting agent is selected from any one of sodium naphthalenesulfonate, sodium lauryl sulfate, laquer powder BX, alkylphenol polyoxyethylene ether formaldehyde condensate sodium sulfate, alkylbenzene polyoxyethylene ether phosphate, phenylethylphenol polyoxyethylene ether phosphate, sodium alkyl sulfate, sodium alkyl sulfonate, and dodecylbenzenesulfonic acid, or a mixture of two or more in any proportion.

[0018] In the above technical solution, the dispersant is selected from any one of sodium polycarboxylate, sodium lignin sulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate, sodium naphthalenesulfonic acid formaldehyde condensate, non-ionic hydroxy polyethylene oxide block copolymer, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester, and glycerol fatty acid ester polyoxyethylene ether, or a mixture of two or more in any proportion.

[0019] In the above technical solution, the antifreeze agent is selected from any one of ethylene glycol, propylene glycol, glycerol, glycerin, and urea, or a mixture of two or more of them in any proportion.

[0020] In the above technical solution, the preservative is selected from any one of sodium benzoate, benzoic acid, potassium sorbate, and kasone, or a mixture of two or more of them in any proportion.

[0021] In the above technical solution, the defoaming agent is selected from any one of polydimethylsiloxane, silicone oil, glycerol ricinoleate, distearylethylenediamine, or a mixture of two or more in any proportion.

[0022] In the above technical solution, the thickener is selected from any one of xanthan gum, hydroxymethyl cellulose, hydroxyethyl cellulose, and magnesium aluminum silicate, or a mixture of two or more in any proportion.

[0023] In the above technical solution, the disintegrant is selected from any one of sodium chloride, ammonium sulfate, sodium carbonate, sodium bicarbonate, sodium sulfate, or a mixture of two or more of them in any proportion.

[0024] In the above technical solution, the emulsifier is selected from any one of calcium dodecylbenzenesulfonate, nonylphenol polyoxyethylene ether, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, Span 60, Span 80, Tween 60, Tween 80, fatty alcohol polyoxyethylene ether, styrylphenol polyoxyethylene ether, alkylaryl polyoxyethylene ether polyoxypropylene ether, or a mixture of two or more in any proportion.

[0025] In the above technical solution, the filler is selected from any one of kaolin, white carbon black, corn starch, attapulgite, calcium carbonate, light calcium carbonate, diatomaceous earth, and bentonite, or a mixture of two or more in any proportion.

[0026] In the above technical solution, the solvent is selected from any one of N,N-dimethylformamide, N,N-dimethylacetamide, N,N-dimethylformamide, xylene, ethanol, soybean oil, methyl oleate, corn oil, rapeseed oil, and dodecane, or a mixture of two or more in any proportion.

[0027] In the above technical solution, the sanitary insecticide composition, when in the form of suspension concentrate, oil suspension concentrate, dry suspension concentrate, wettable powder and water dispersible granules, can be prepared according to conventional methods or existing methods in the art.

[0028] The present invention also provides an application of the sanitary insecticide composition containing cyfluthrin and propoxur in preventing and controlling sanitary pests.

[0029] In the above technical solution, the sanitary pests refer to Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Aedes harassingus, Chironomids, Housefly, Cityfly, Bigheaded Chrysopagus, Lucilia sericata, Lucilia cuprifolia, Bright Greenfly, Summer Toilet Fly, Yuan Toilet Fly, German Cockroach, and American Cockroach.

[0030] In the above technical solution, the sanitary pests are preferably resistant varieties such as Culex pipiens pallens, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Housefly, Cityfly, Lucilia sericata, Lucilia cuprina, German cockroach, and American cockroach.

[0031] In the above technical solution, when the sanitary insecticide composition containing cyfluthrin and propoxur is used to control sanitary pests, the sanitary insecticide composition is diluted 50-300 times with water and then sprayed on surfaces such as walls, doors, windows, ceilings and home furnishings, so that the sanitary insecticide composition remains on the surfaces of the above objects, thereby knocking down and killing the sanitary pests.

[0032] Compared with the existing technology, it has the following characteristics:

[0033] (1) A diamide compound is applied to the field of sanitary pest retention spraying;

[0034] (2) The synergistic effect of compounding with propoxur is obvious, which improves the lethal effect against sanitary pests;

[0035] (3) Good environmental compatibility, reducing the amount of pesticides used;

[0036] (4) The combination of two active ingredients with different mechanisms of action can effectively reduce the problem of pest resistance that may arise from long-term use of a single agent. DETAILED DESCRIPTION

[0037] The following describes in detail the specific implementation of the technical solution of the present invention, but the present invention is not limited to the following description:

[0038] The preparation methods of the dosage forms in each embodiment of the present invention are as follows:

[0039] The laboratory preparation method of the suspension concentrate is as follows: a wetting agent, a dispersant, an antifreeze agent, a preservative, a defoamer, a thickener, and deionized water are weighed according to a ratio and added to a beaker and mixed evenly. Then, cyfluthrin and propoxur are added to the beaker, and then the suspension concentrate is transferred to a sand mill. Zirconia beads are added to the sand mill and ground for 2-3 hours. The thickener is added and ground for another 0.5 hour until the particle size D95 is controlled to be below 5 microns. The suspension concentrate is then filtered to remove the zirconium oxide beads.

[0040] The laboratory preparation method of the oil suspension concentrate is as follows: dispersant, wetting agent, emulsifier, defoamer, thickener and solvent are weighed according to the ratio and added into a beaker and mixed evenly, then cyfluthrin and propoxur are added into the beaker, and then the mixture is transferred to a sand mill, zirconium oxide beads are added into the sand mill, and the mixture is ground for 2-3 hours, and the thickener is added and ground for 0.5 hours, so that the particle size D95 is controlled below 5 microns, and the zirconium oxide beads are removed by filtration to obtain the oil suspension concentrate.

[0041] The laboratory preparation method of the dry suspension concentrate is as follows: the wetting agent, dispersant and filler are weighed according to the proportion, added to a beaker and mixed evenly, and then cyflumilast and propoxur are added to the beaker, and then transferred to a sand mill, zirconium oxide beads are added to the sand mill, and ground for 2-3 hours to control the particle size D95 to be below 5 microns, the zirconium oxide beads are filtered to remove the zirconium oxide beads, and the resulting material is dried in a spray dryer to obtain the suspension concentrate.

[0042] The laboratory preparation method of wettable powder is as follows: cyflumilast, propoxur, wetting agent, dispersant and filler are weighed according to the ratio, added into a food processor and mixed evenly, and then put into a jet mill to grind.

[0043] The laboratory preparation method of water-dispersible granules is as follows: ciprofloxacin, propoxur, wetting agent, dispersant, disintegrant and filler are weighed according to the ratio, added into a food processor and mixed evenly, then put into a jet mill for grinding, mixed again with a food processor, added with an appropriate amount of water, extruded into granules with a granulator, and dried in a 45°C oven.

[0044] The present invention will be described below in conjunction with specific embodiments:

[0045] Formulation Example 1: 18% cyprodinil·propoxur suspension concentrate

[0046] 15% cyflumizone, 3% propoxur, 1% sodium naphthalenesulfonate, 8% sodium polycarboxylate, 3% ethylene glycol, 0.3% sodium benzoate, 0.1% distearyl ethylenediamine, 3% xanthan gum, and deionized water to 100%.

[0047] Formulation Example 2: 16% cyprodinil·propoxur suspension concentrate

[0048] 15% cyflumizone, 1% propoxur, 3% sodium lauryl sulfate, 5% sodium lignin sulfonate, 4% propylene glycol, 1% benzoic acid, 0.4% silicone oil, 2.5% hydroxymethyl cellulose, and deionized water to 100%.

[0049] Formulation Example 3: 10% cyprodinil·propoxur suspension concentrate

[0050] 5% cyfluthrin, 5% propoxur, 5% lakai powder BX, 3% alkylphenol polyoxyethylene ether formaldehyde condensate, 6% glycerol, 1.5% potassium sorbate, 0.7% glyceryl ricinoleate, 1.5% hydroxyethyl cellulose, and deionized water is added to 100%.

[0051] Formulation Example 4: 12% cyprodinil·propoxur suspension concentrate

[0052] 2% cyflumizone, 10% propoxur, 8% sodium sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, 1% sodium naphthalenesulfonic acid formaldehyde condensate, 7% glycerin, 2% kasonide, 1% polydimethylsiloxane, 0.5% magnesium aluminum silicate, and deionized water is added to 100%.

[0053] Formulation Example 5: 18% cyprodinil·propoxur oil suspension concentrate

[0054] 15% cyflumizone, 3% propoxur, 0.2% alkylbenzene polyoxyethylene ether phosphate, 3% non-ionic hydroxy polyethylene oxide block copolymer, 6% calcium dodecylbenzenesulfonate, 0.2% distearylethylenediamine, 5% xanthan gum, methyl oleate is made up to 100%.

[0055] Formulation Example 6: 27% cyprodinil·propoxur oil suspension concentrate

[0056] 25% cyflumizone, 2% propoxur, 0.5% phenylethylphenol polyoxyethylene ether phosphate, 1.5% fatty amine polyoxyethylene ether, 5% nonylphenol polyoxyethylene ether, 2% silicone oil, 3% hydroxymethyl cellulose, and corn oil is added to 100%.

[0057] Formulation Example 7: 20% cyprodinil·propoxur oil suspension concentrate

[0058] 10% cyflumizone, 10% propoxur, 0.8% sodium lauryl sulfate, 1% fatty acid polyoxyethylene ester, 3% alkylphenol polyoxyethylene ether, 3% glyceryl ricinoleate, 2% hydroxyethyl cellulose, and rapeseed oil is added to 100%.

[0059] Formulation Example 8: 8% cyprodinil·propoxur oil suspension concentrate

[0060] 2% cyprodinil, 6% propoxur, 1% sodium alkyl sulfonate, 0.3% glycerol fatty acid ester polyoxyethylene ether, 2% castor oil polyoxyethylene ether, 5% polydimethylsiloxane, 0.2% magnesium aluminum silicate, and dodecane is added to make up 100%.

[0061] Formulation Example 9: 18% cyprodinil·propoxur dry suspension concentrate

[0062] 15% of cyflumizone, 3% of propoxur, 1% of phenylethylphenol polyoxyethylene ether phosphate, 8% of sodium naphthalenesulfonic acid formaldehyde condensate, and kaolin to 100%.

[0063] Formulation Example 10: 55% cyprodinil·propoxur dry suspension concentrate

[0064] 50% cyflumizone, 5% propoxur, 3% sodium lauryl sulfate, 5% alkylphenol polyoxyethylene ether formaldehyde condensate, and corn starch is supplemented to 100%.

[0065] Formulation Example 11: 30% cyprodinil·propoxur dry suspension concentrate

[0066] 20% of cyfluthrin, 10% of propoxur, 5% of sodium alkyl sulfonate, 3% of sodium lignin sulfonate, and attapulgite to 100%.

[0067] Formulation Example 12: 12% cyprodinil·propoxur dry suspension concentrate

[0068] 2% cyflumizone, 10% propoxur, 8% dodecylbenzenesulfonic acid, 1% sodium polycarboxylate, and calcium carbonate to 100%.

[0069] Formulation Example 13: 18% cyprodinil·propoxur wettable powder

[0070] 15% cyflumizone, 3% propoxur, 2% sodium naphthalenesulfonate, 18% sodium polycarboxylate, and kaolin to 100%.

[0071] Formulation Example 14: 65% cyprodinil·propoxur wettable powder

[0072] 60% cyfluthrin, 5% propoxur, 3% sodium lauryl sulfate, 14% sodium lignin sulfonate, 10% white carbon black, and corn starch to make up 100%.

[0073] Formulation Example 15: 30% cyprodinil·propoxur wettable powder

[0074] 20% of cyflumizone, 10% of propoxur, 5% of lakai powder BX, 11% of alkylphenol polyoxyethylene ether formaldehyde condensate, and attapulgite to 100%.

[0075] Formulation Example 16: 13% cyprodinil·propoxur wettable powder

[0076] 3% of cyflumizone, 9% of propoxur, 6% of sodium sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, 7% of sodium naphthalenesulfonic acid formaldehyde condensate, and kaolin is added to make up 100%.

[0077] Formulation Example 17: 18% cyprodinil·propoxur water dispersible granules

[0078] 15% cyflumizone, 3% propoxur, 2% alkylbenzene polyoxyethylene ether phosphate, 20% nonionic hydroxy polyethylene oxide block copolymer, 2% sodium sulfate, and bentonite to 100%.

[0079] Formulation Example 18: 64% cyprodinil·propoxur water dispersible granules

[0080] 60% cyfluthrin, 4% propoxur, 6% phenylethylphenol polyoxyethylene ether phosphate, 15% fatty amine polyoxyethylene ether, 2% sodium carbonate, 2% sodium bicarbonate, and diatomaceous earth to 100%.

[0081] Formulation Example 19: 30% cyprodinil·propoxur water dispersible granules

[0082] 20% cyfluthrin, 10% propoxur, 10% sodium lauryl sulfate, 10% polyoxyethylene fatty acid esters, 6% ammonium sulfate, and light calcium supplemented to 100%.

[0083] Formulation Example 20: 20% cyprodinil·propoxur water dispersible granules

[0084] 10% cyflumizone, 10% propoxur, 10% sodium alkyl sulfonate, 5% dodecylbenzenesulfonic acid, 4% fatty acid polyoxyethylene ester, 1% glycerol fatty acid ester polyoxyethylene ether, 8% sodium chloride, and calcium carbonate is added to make up 100%.

[0085] Formulation Example 21: 50% cyprodinil·propoxur suspension concentrate

[0086] 40% cyflumizone, 10% propoxur, 1% sodium naphthalenesulfonate, 8% sodium polycarboxylate, 3% ethylene glycol, 0.3% sodium benzoate, 0.1% polydimethylsiloxane, 3% xanthan gum, and deionized water to 100%.

[0087] Formulation Example 22: 35% cyprodinil·propoxur oil suspension concentrate

[0088] 25% cyflumizone, 10% propoxur, 0.2% alkylbenzene polyoxyethylene ether phosphate, 3% non-ionic hydroxy polyethylene oxide block copolymer, 6% calcium dodecylbenzenesulfonate, 0.2% polydimethylsiloxane, 5% xanthan gum, methyl oleate makes up to 100%.

[0089] Formulation Example 23: 60% cyprodinil·propoxur dry suspension concentrate

[0090] 50% of cyflumizone, 10% of propoxur, 1% of phenylethylphenol polyoxyethylene ether phosphate, 8% of sodium naphthalenesulfonic acid formaldehyde condensate, and kaolin to 100%.

[0091] Formulation Example 24: 70% cyprodinil·propoxur wettable powder

[0092] 60% cyflumizone, 10% propoxur, 2% sodium naphthalenesulfonate, 7% sodium polycarboxylate, and kaolin to 100%.

[0093] Formulation Example 25: 70% cyprodinil·propoxur water dispersible granules

[0094] 60% cyflumizone, 10% propoxur, 2% alkylbenzene polyoxyethylene ether phosphate, 7% nonionic hydroxy polyethylene oxide block copolymer, 2% sodium sulfate, and bentonite to make up 100%.

[0095] The following specific tests are used to test the efficacy of the drug:

[0096] Control agent 1: 10% chlorpromazine-propoxur suspension (commercially available)

[0097] Control agent 2: 10% cischlorfenuron wettable powder (commercially available)

[0098] Experiment 1: Determination of resistance levels of Culex pipiens pallens and housefly in the wild in Nanjing

[0099] (1) Experimental subjects: Culex pipiens pallens reared in the laboratory, the first generation of Culex pipiens pallens reared in the laboratory from the wild in Nanjing, houseflies reared in the laboratory, the first generation of houseflies reared in the laboratory from the wild in Nanjing

[0100] (2) Test method: Refer to the Guidelines for Indoor Bioassay of Pesticides Part 1: Contact Activity Test, and use the spot method NY / T1154.1-2006 to conduct activity assay on Culex pipiens pallens and Musca domestica.

[0101] (3) Test agent: Propoxur original drug

[0102] (4) Test results:

[0103] Table 1 Activity data of Culex pipiens pallens and housefly in the laboratory and in the wild in Nanjing

[0104]

[0105] As can be seen from the table above, the resistance of Culex pipiens pallens to propoxur in the wild in Nanjing is 33 times that of the laboratory strain, and the resistance of houseflies to propoxur in the wild in Nanjing is 29 times that of the laboratory strain. Hereinafter, the Culex pipiens pallens and houseflies collected from the wild in Nanjing are referred to as field-resistant strains.

[0106] Verification experiment 2: Determination of resistance levels of Culex pipiens and housefly in the wild in Nanjing

[0107] (1) Experimental subjects: Culex pipiens pallens reared in the laboratory, the first generation of Culex pipiens pallens reared in the laboratory from the wild in Nanjing, houseflies reared in the laboratory, the first generation of houseflies reared in the laboratory from the wild in Nanjing

[0108] (2) Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spray test.

[0109] (3) Test agent: Example 1

[0110] (4) Test results:

[0111] Table 2 Residual spraying data of Culex pipiens pallens and housefly in the laboratory and in the wild in Nanjing

[0112]

[0113] From the residual spraying test data in Table 2, it can be seen that the KT50 of Culex pipiens and houseflies in the wild in Nanjing was significantly higher than that of the laboratory strains, which also confirmed that the Nanjing strains had developed resistance to propoxur.

[0114] Verification test 3: Co-toxicity coefficient of ciprofloxacin and propoxur against Culex pipiens pallens

[0115] (1) Test subjects: Culex pipiens (laboratory reared)

[0116] (2) Test method: Refer to the Guidelines for Indoor Bioassay of Pesticides Part 1: Contact Activity Test, and use the spot method NY / T1154.1-2006 to conduct activity test on Culex pipiens pallens.

[0117] (3) Data statistics: The co-toxicity coefficient method was used to evaluate the activity of the combination of the two against Culex pipiens pallens. The toxicity regression equation was then calculated using DPS statistical software to obtain the LD50 value of each drug. The toxicity index and co-toxicity coefficient of the drug were then calculated according to the Sun Yunpei method. A co-toxicity coefficient greater than 120 indicates a synergistic effect, a co-toxicity coefficient between 80-120 indicates an additive effect, and a co-toxicity coefficient less than 80 indicates an antagonistic effect. The test results are shown in the following table:

[0118] Table 3 Co-toxicity coefficient of cyfluthrin and propoxur to Culex pipiens pallens

[0119]

[0120] It can be seen from Table 3 that the co-toxicity coefficient of ciprofloxacin:propoxur at the ratio of 13:1 to 5:1 is greater than 120, which is a synergistic effect.

[0121] Verification test 4: efficacy test for preventing and controlling mosquitoes and flies

[0122] (1) Test subjects: Culex pipiens and housefly (first generation of field-resistant strains)

[0123] (2) Test method: Refer to GB / T13919.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spray test.

[0124] (3) Test agents: Preparation Examples 1, 5, 9, 13, and 17 were diluted with water to 900 ppm, and control agents 1 and 2 were diluted with water to 900 ppm.

[0125] (4) Statistics:

[0126] Table 4 Efficacy test data of several treatments against Culex pipiens and housefly

[0127]

[0128]

[0129] As can be seen from Table 4, the KT50 values ​​of several examples of the ciprofloxacin and propoxur combination against resistant Culex pipiens pallens and houseflies were all less than 8 minutes, and the 24-hour mortality rates were all greater than 95%. In contrast, the KT50 values ​​of control agents 1 and 2 against resistant Culex pipiens pallens and houseflies were all greater than 14 minutes, and the 24-hour mortality rates were all less than or equal to 80%. This indicates that the ciprofloxacin and propoxur combination, when applied using a residual spraying method, has a good control effect against resistant strains of Culex pipiens pallens and houseflies.

[0130] The above examples are only for illustrating the technical concept and technical features of the present invention and are not intended to limit the scope of protection of the present invention. Any equivalent transformation or modification made based on the essence of the present invention should be included in the scope of protection of the present invention.

Claims

1. An application of a sanitary insecticide composition containing ciprofloxacin and propoxur in controlling sanitary pests, characterized in that: The sanitary pests include Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Argus harassingus, Chironomids, Housefly, Cityfly, Chrysomelidae megacephala, Lucilia sericata, Lucilia cuprifolia, Lucilia luminescent, Summer toilet fly, Meta toilet fly, German cockroach, and American cockroach. The active ingredients of the sanitary insecticide composition are cyprosulfuron and propoxur, and the total weight of the active ingredients accounts for 2%-70% of the total weight of the sanitary insecticide composition, and the balance is adjuvants. The weight ratio of cyprosulfuron to propoxur is 13:1 to 5:

1.

2. The use according to claim 1, characterized in that: The auxiliary agent is a mixture of three or more of a wetting agent, a dispersant, an antifreeze agent, a preservative, a defoaming agent, a thickener, a disintegrant, an emulsifier, a filler, a solvent and deionized water in any proportion; the sanitary insecticide composition has the dosage form of a suspension concentrate, an oil suspension concentrate, a dry suspension concentrate, a wettable powder and a water-dispersible granule.

3. The use according to claim 2, characterized in that: When the sanitary insecticide composition is in the form of a suspension, it comprises the following raw materials in percentage by weight: 1-40% of ciprofloxacin, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, 3-7% of an antifreeze agent, 0.3-2% of a preservative, 0.1-1% of a defoamer, 0.5-3% of a thickener, and deionized water is added to make up to 100%.

4. The use according to claim 2, characterized in that: When the sanitary insecticide composition is in the form of an oil suspension, it comprises the following raw materials in percentage by weight: 1-25% of cyflumizone, 1-10% of propoxur, 0.2-1% of a wetting agent, 0.3-3% of a dispersant, 2-6% of an emulsifier, 0.2-5% of a defoamer, and 0.2-5% of a thickener, with the solvent making up to 100%.

5. The use according to claim 2, characterized in that: When the sanitary insecticide composition is in the form of a dry suspension, it comprises the following raw materials in percentage by weight: 1-50% of ciprofloxacin, 1-10% of propoxur, 1-8% of a wetting agent, 1-8% of a dispersant, and the filler is added to make up 100%.

6. The use according to claim 2, characterized in that: When the sanitary insecticide composition is in the form of a wettable powder, it comprises the following raw materials in percentage by weight: 1-60% of ciprofloxacin, 1-10% of propoxur, 2-6% of a wetting agent, 7-18% of a dispersant, and the filler is added to make up 100%.

7. The use according to claim 1, characterized in that: When the sanitary insecticide composition is in the form of water-dispersible granules, it comprises the following raw materials in weight percentage: 1-60% of ciprofloxacin, 1-10% of propoxur, 2-15% of a wetting agent, 5-20% of a dispersant, 2-8% of a disintegrant, and the filler is supplemented to 100%.

8. The use according to claim 1, characterized in that When the sanitary insecticide composition containing cyfluthrin and propoxur is used to control sanitary pests, the sanitary insecticide composition is diluted 30-300 times with water and then sprayed on walls, doors, windows, ceilings and household surfaces, so that the sanitary insecticide composition remains on the surfaces of the above objects, thereby knocking down and killing the sanitary pests.

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