A binary hygiene fly composition containing cycloprothrin and its use

Abstract

The application discloses a binary health insecticidal composition containing cycloprothrin and application thereof, effective components are cycloprothin and neonicotinoid insecticides; the total content of the cycloprothin and the neonicotinoid insecticides is 2% to 80%; and the weight ratio of the cycloprothin to the neonicotinoid insecticides is 10:1 to 1:20. The fly-killing composition adopts the effective components with two different action mechanisms, is mixed in a suitable ratio, and has obvious synergistic effect compared with single agents, can effectively control pests, delays the occurrence of drug resistance, and the addition of the attracting composition is innovative.

Description

TECHNICAL FIELD

[0001] The present application relates to a sanitary insecticidal composition, in particular to a binary sanitary insecticidal composition containing cyflumetofen and its application, and the effective component is cyflumetofen and neonicotinoid insecticide. BACKGROUND

[0002] For a long time, the sanitary insecticide is mainly pyrethroid insecticide, and is mostly single agent or two pyrethroid insecticides to achieve the effect of killing sanitary pests. Since the pyrethroid insecticide has entered the market, it has rapidly occupied the field of sanitary insecticide due to high efficiency and low toxicity, but long-term use has caused some resistance problems.

[0003] Cyflumetofen is a newly developed compound, and its application in the sanitary field has not been seen on the market, and it is mainly used for crops. Neonicotinoid insecticide is a kind of artificial synthesis of nicotine compounds which has killing effect on most pests, and mainly kills pests by stomach poison. The application of two different mechanism insecticides has not been seen.

[0004] Residual spraying is a common way of using insecticides in the field of sanitary pest control. The traditional residual spraying relies on the residual of the insecticide on the surface of the object to passively kill the pests contacting the surface. Therefore, the traditional residual spraying needs to cover most of the surfaces that the pests may contact, and the amount of drug used is large, the pollution is serious, and the available insecticides have limitations. By adding some attractants to the residual spraying formulation, the traditional residual spraying can be changed from passive to active to attract pests to contact or feed on the insecticide. The coverage of the insecticide can be changed from local to reduce the amount of drug used and reduce pollution. At the same time, the stomach poison insecticide can also be used. This way has certain limitations, and the short persistence of the attractant leads to the inability to maintain the desired advantages. SUMMARY

[0005] The technical problem to be solved by the present application is to provide a binary sanitary insecticidal composition containing cyflumetofen and its application in view of the deficiencies in the prior art. The present application solves the problem of passive prevention and control of residual spraying by adding an attractant composition, and can also prolong the persistence of the attractant.

[0006] In order to achieve the above purpose, the present application adopts the following technical scheme:

[0007] The present application first provides a binary sanitary insecticidal composition containing cyflumetofen, and the effective component is cyflumetofen and neonicotinoid insecticide. The total weight of cyflumetofen and neonicotinoid insecticide accounts for 2% to 80% of the total weight of the sanitary insecticidal composition, and the balance is auxiliary materials.

[0008] The new neonicotinoid insecticide is any one of imidacloprid, acetamiprid, thiacloprid, thiamethoxam, dinotefuran, sulfoxaflor, chloropyrifos, clothianidin.

[0009] The weight ratio of the cycloprothrin and the neonicotinoid insecticide is 10:1-1:20, preferably 1:1-1:20.

[0010] The auxiliary material is an auxiliary agent and an attractant composition, wherein the auxiliary agent is a mixture of three or more of wetting agent, dispersant, filler, antifreeze, preservative, defoaming agent, thickening agent, PH regulator, deionized water, disintegrant, in any proportion.

[0011] The binary health insecticidal composition has a dosage form of wettable powder, suspension, water dispersible granule, dry suspension.

[0012] When the binary health insecticidal composition has a dosage form of wettable powder, the composition comprises the following raw materials in the following weight percentage: 1-40% of cycloprothrin, 1-40% of neonicotinoid insecticide, 2-6% of wetting agent, 7-18% of dispersant, 2-5% of attractant composition, and the rest is filler.

[0013] When the binary health insecticidal composition has a dosage form of suspension, the composition comprises the following raw materials in the following weight percentage: 1-20% of cycloprothrin, 1-20% of neonicotinoid insecticide, 1-8% of wetting agent, 1-20% of dispersant, 3-7% of antifreeze, 0.3-2% of preservative, 0.1-1% of defoaming agent, 0.5-3% of thickening agent, 0.1-0.5% of PH regulator, 2-5% of attractant composition, and the rest is deionized water.

[0014] When the binary health insecticidal composition has a dosage form of water dispersible granule, the composition comprises the following raw materials in the following weight percentage: 1-40% of cycloprothrin, 1-40% of neonicotinoid insecticide, 2-12% of wetting agent, 5-18% of dispersant, 2-8% of disintegrant, 2-5% of attractant composition, and the rest is filler.

[0015] When the binary health insecticidal composition has a dosage form of dry suspension, the composition comprises the following raw materials in the following weight percentage: 1-20% of cycloprothrin, 1-40% of neonicotinoid insecticide, 1-8% of wetting agent, 1-8% of dispersant, 2-5% of attractant composition, and the rest is filler.

[0016] The technical scheme above, the bait composition includes the following raw materials in percentage by weight: agar 5%, sorbitol 5%, attractant 60%, propylene glycol 5%, xanthan gum 0.5%, magnesium aluminum silicate 0.5%-1%, and the rest is deionized water; the attractant is selected from any one of brown sugar, white granulated sugar, butter flavor, cis-9-tricosene.

[0017] The technical scheme above, the bait composition is prepared by the following method: weighing agar, sorbitol, attractant, propylene glycol, xanthan gum, and water in proportion, heating to the puffed state, then adding 0.5%-0.7% magnesium aluminum silicate, stirring uniformly to obtain a wet gel-like bait composition; as in the above step, when the amount of magnesium aluminum silicate added is 0.7%-1%, the wet gel-like bait composition is naturally air-dried or oven-dried to obtain a dry gel-like bait composition.

[0018] The technical scheme above, the wet gel-like bait composition is used for suspension agent and is directly added; the dry gel-like bait composition is used for wettable powder, water dispersible granules, and dry suspension agent after being pulverized by airflow.

[0019] The technical scheme above, the dispersant is selected from any one or a mixture of two of modified polyacrylic acid copolymer, modified rosin polyether phosphate, hydrophobic group modified carboxylic acid copolymer, sodium lignosulfonate, sodium alkyl naphthalene sulfonate formaldehyde polycondensate, sodium methyl naphthalene sulfonate formaldehyde condensate, alkyl phenol polyoxyethylene ether phosphate, phenylethyl phenol polyoxyethylene ether phosphate, non-ionic hydroxyl polyethylene oxide block copolymer, sodium fatty alcohol polyoxyethylene ether sulfonate, and sodium fatty alcohol polyoxyethylene ether sulfate.

[0020] The technical scheme above, the wetting agent is selected from any one or a mixture of two of sodium polycarboxylate, fatty alcohol polyoxyethylene ether, fatty acid polyoxyethylene ether, fatty amine polyoxyethylene ether, castor oil polyoxyethylene ether, polyarylphenol polyoxyethylene ether (formaldehyde condensate), trisiloxane polyoxyethylene ether, sodium alpha-alkenyl sulfonate, alkyl benzene polyoxyethylene ether phosphate, and sodium dodecyl sulfate.

[0021] The technical scheme above, the disintegrant is selected from any one or a mixture of two of sodium chloride, ammonium sulfate, sodium carbonate, sodium bicarbonate, and sodium sulfate.

[0022] The technical scheme above, the filler is selected from any one or a mixture of two of kaolin, white carbon black, corn starch, attapulgite, calcium carbonate, light calcium, and diatomite.

[0023] The technical scheme above, the antifreeze agent is any one or a mixture of two of ethylene glycol, propylene glycol, glycerol, and urea.

[0024] The thickening agent is any one of xanthan gum, hydroxyethyl cellulose, methyl cellulose, magnesium aluminum silicate and organic bentonite or a mixture of two.

[0025] The preservative is any one of sodium benzoate, potassium sorbate and carboxin or a mixture of two.

[0026] The defoaming agent is any one of polydimethylsiloxane, silicone oil and glyceryl ricinoleate or a mixture of two.

[0027] The PH regulator is any one of citric acid and benzoic acid.

[0028] The hygienic insecticidal composition is prepared according to the conventional method or the existing method.

[0029] The application provides an application of the hygienic insecticidal composition containing cycloprothrin in the field of hygiene.

[0030] The flies include flies of Muscidae and Calliphoridae, and are specifically housefly, Muscina stabulans, Fannia scalaris, Fannia canicularis, Fannia femoralis, Muscina assimilis, Phaenicia coeruleocephala, Phaenicia sericata, Lucilia caprina, Lucilia luciliae, Calliphora erythrocephala, Calliphora megacephala, Fannia scalaris and Fannia canicularis.

[0031] When the hygienic insecticidal composition containing cycloprothrin is used to control flies in the field of hygiene, the insecticidal composition is diluted 50-200 times with water by the retention spraying control mode, and the liquid medicine is sprayed on the ground, the wall surface, the railing and the fence surface by using the constant spraying equipment.

[0032] Compared with the prior art, the application has the following characteristics:

[0033] The hygienic insecticidal composition has good control effect on hygienic pests which are resistant to the pyrethroid insecticide, and the control efficiency is improved; the combination of the insecticides with different action mechanisms can delay the resistance, and provides a new method for controlling hygienic pests and delaying the resistance; the addition of the attractant composition greatly improves the killing effect of the composition on flies and reduces the irritability to non-target animals. DETAILED DESCRIPTION

[0034] The following describes the specific implementation of the technical scheme of the application in detail, but the application is not limited to the following description:

[0035] In the following examples of the application, the attractant composition is prepared by the following method:

[0036] (1) Take 5g agar, 0.5g xanthan gum, 0.5g magnesium aluminum silicate, 24g water, heat to agar and xanthan gum swelling;

[0037] (2) Take 60g attractant, 5g sorbitol, 5g propylene glycol, add to the solution of step (1), stir evenly, get wet gel-like attractant composition, for suspension concentrate, direct addition;

[0038] (3) Repeat steps (1) and (2) with the difference that the amount of magnesium aluminum silicate is adjusted to 1g, and the amount of water is adjusted to 23.5g, to prepare a gel which is dried by self-heating to form a dry gel-like attractant composition, which is used for wettable powder, water dispersible granules, dry suspension after being pulverized by airflow.

[0039] In the following examples of the present application, the preparation methods of various dosage forms are as follows:

[0040] The laboratory preparation method of wettable powder is as follows: the cycloprothrin, neonicotinoid insecticide, wetting agent, dispersing agent, attractant composition and filler are mixed uniformly in a food processor, and then pulverized in an airflow pulverizer to obtain the wettable powder.

[0041] The laboratory preparation method of suspension concentrate is as follows: the wetting agent, dispersing agent, antifreeze agent, preservative, defoaming agent, pH regulator, attractant composition and deionized water are mixed uniformly in a beaker, and then the cycloprothrin and neonicotinoid insecticide are added into the beaker, and then transferred to a sand mill, zirconium oxide beads are added into the sand mill, and ground for 2-3h, and then the thickening agent is added and ground for another 0.5h, so that the particle size D 95 is controlled to be less than 5 microns, the zirconium oxide beads are removed by filtration, and the suspension concentrate is obtained.

[0042] The laboratory preparation method of water dispersible granules is as follows: the cycloprothrin, neonicotinoid insecticide, wetting agent, dispersing agent, disintegrating agent, attractant composition and filler are mixed uniformly in a food processor, and then pulverized in an airflow pulverizer, and then mixed again in a food processor, and then a proper amount of deionized water is added, and then extruded and granulated by a granulator, and then dried at 54℃ for 2h to obtain the water dispersible granules.

[0043] The laboratory preparation method of dry suspension is as follows: the wetting agent, dispersing agent, attractant composition, filler and deionized water are mixed uniformly in a beaker, and then the cycloprothrin and neonicotinoid insecticide are added into the beaker, and then transferred to a sand mill, zirconium oxide beads are added into the sand mill, and ground for 2-3h, so that the particle size D 95 is controlled to be less than 5 microns, and then the obtained material is dried by a spray dryer to obtain the dry suspension.

[0044] The present application will be described in conjunction with specific examples as follows:

[0045] Formulation Example 1: 16% cyromazine*imidacloprid suspension concentrate

[0046] Cyromazine 8 g, imidacloprid 8 g, sodium polycarboxylate 4 g, modified polyacrylic acid copolymer 5 g, propylene glycol 5 g, potassium sorbate 0.5 g, citric acid 0.1 g, magnesium aluminum silicate 0.5 g, xanthan gum 0.3 g, silicone oil 0.2 g, attractant composition (attractant brown sugar) 2 g, deionized water to 100 g. The suspension concentrate was prepared by the above method.

[0047] Formulation Example 2: 5% cyromazine*thiacloprid suspension concentrate

[0048] Cyromazine 1 g, thiacloprid 4 g, sodium polycarboxylate 5 g, fatty alcohol polyoxyethylene ether 2 g, modified rosin polyether phosphate 4 g, sodium lignosulfonate 2 g, urea 3 g, potassium sorbate 0.5 g, magnesium aluminum silicate 0.5 g, xanthan gum 0.4 g, polydimethylsiloxane 0.2 g, benzoic acid 0.2 g, attractant composition (attractant white sugar) 2 g, deionized water to 100 g. The suspension concentrate was prepared by the above method.

[0049] Formulation Example 3: 30% cyromazine*acetamiprid suspension concentrate

[0050] Cyromazine 10 g, acetamiprid 20 g, alkylphenyl polyoxyethylene ether phosphate 8 g, sodium lignosulfonate 2 g, alkylphenol polyoxyethylene ether phosphate 3 g, ethylene glycol 7 g, potassium sorbate 0.3 g, magnesium aluminum silicate 0.25 g, xanthan gum 0.25 g, glyceryl ricinoleate 0.2 g, citric acid 0.3 g, attractant composition (attractant butter flavor) 5 g, deionized water to 100 g. The suspension concentrate was prepared by the above method.

[0051] Formulation Example 4: 5% cyromazine*thiamethoxam suspension concentrate

[0052] Cyromazine 2.5 g, thiamethoxam 2.5 g, fatty alcohol polyoxyethylene ether 2 g, modified rosin polyether phosphate 5 g, sodium dodecyl sulfate 5 g, sodium lignosulfonate 5 g, nonionic hydroxyl polyethylene oxide block copolymer 5 g, glycerol 7 g, sodium benzoate 2 g, magnesium aluminum silicate 2.6 g, xanthan gum 0.4 g, glyceryl ricinoleate 1 g, attractant composition (attractant cis-9-tricosene) 2 g, citric acid 0.5 g, deionized water to 100 g. The suspension concentrate was prepared by the above method.

[0053] Formulation Example 5: 15% cyromazine*diamethoate suspension concentrate

[0054] Cycloprothrin 5 g, Fipronil 10 g, fatty acid polyoxyethylene ether 7 g, fatty alcohol polyoxyethylene ether sodium sulfonate 1 g, propylene glycol 7 g, potassium sorbate 0.3 g, citric acid 0.3 g, magnesium aluminum silicate 1 g, xanthan gum 0.4 g, glyceryl ricinoleate 1 g, attractant composition (attractant red sugar) 3 g, and deionized water to 100 g. The suspension was prepared according to the above method.

[0055] Formulation Example 6: 2% cycloprothrin · fipronil suspension

[0056] Cycloprothrin 1 g, fipronil 1 g, hydrophobically modified carboxylic acid copolymer 7 g, sodium salt of methylnaphthalene sulfonic acid formaldehyde condensate 1 g, sodium fatty alcohol polyoxyethylene ether sulfate 1 g, sodium α-olefin sulfonate 1 g, propylene glycol 5 g, kaolin 1.8 g, citric acid 0.5 g, magnesium aluminum silicate 2 g, xanthan gum 0.4 g, silicone oil 0.5 g, attractant composition (attractant cis-9-tricosene) 2 g, and deionized water to 100 g. The suspension was prepared according to the above method.

[0057] Formulation Example 7: 10% cycloprothrin · chlorothalonil suspension

[0058] Cycloprothrin 2 g, chlorothalonil 8 g, sodium fatty alcohol polyoxyethylene ether sulfate 7 g, fatty amine polyoxyethylene ether 4 g, propylene glycol 5 g, potassium sorbate 2 g, citric acid 0.4 g, magnesium aluminum silicate 2 g, xanthan gum 0.4 g, silicone oil 0.5 g, attractant composition (attractant cis-9-tricosene) 3 g, and deionized water to 100 g. The suspension was prepared according to the above method.

[0059] Formulation Example 8: 40% cycloprothrin · clothianidin suspension

[0060] Cycloprothrin 20 g, clothianidin 20 g, benzyl phenol polyoxyethylene ether phosphate 2 g, hydrophobically modified carboxylic acid copolymer 2 g, castor oil polyoxyethylene ether 4 g, propylene glycol 5 g, kaolin 2 g, citric acid 0.1 g, magnesium aluminum silicate 2 g, xanthan gum 0.4 g, silicone oil 0.5 g, attractant composition (attractant cis-9-tricosene) 5 g, and deionized water to 100 g. The suspension was prepared according to the above method.

[0061] Formulation Example 9: 30% cycloprothrin · acetamiprid wettable powder

[0062] Cycloprothrin 10 g, acetamiprid 20 g, sodium lignosulfonate 8 g, sodium salt of alkyl naphthalene sulfonic acid formaldehyde condensate 10 g, sodium dodecyl sulfate 2 g, attractant composition (attractant cis-9-tricosene) 4 g, and kaolin to 100 g. The wettable powder was prepared according to the above method.

[0063] Formulation Example 10: 80% cycloprothrin · dinotefuran wettable powder

[0064] Cyflumetofen 40 g, fipronil 40 g, sodium lignosulfonate 10 g, sodium dodecyl sulfate 5 g, attractant composition (attractant sucrose) 2 g, kaolin to make 100 g. A wettable powder was prepared by the above method.

[0065] Preparation Example 11: 4% cyflumetofen·chlorantraniliprole wettable powder

[0066] Cyflumetofen 1 g, chlorantraniliprole 3 g, sodium salt of methylnaphthalenesulfonic acid formaldehyde condensate 7 g, sodium dodecyl sulfate 6 g, attractant composition (attractant cis-9-tricosene) 3.8 g, kaolin to make 100 g. A wettable powder was prepared by the above method.

[0067] Preparation Example 12: 5% cyflumetofen·thiacloprid wettable powder

[0068] Cyflumetofen 2.5 g, thiacloprid 2.5 g, sodium lignosulfonate 10 g, sodium dodecyl sulfate 6 g, attractant composition (attractant cis-9-tricosene) 3.8 g, kaolin to make 100 g. A wettable powder was prepared by the above method.

[0069] Preparation Example 13: 25% cyflumetofen·thiamethoxam wettable powder

[0070] Cyflumetofen 5 g, thiamethoxam 20 g, sodium lignosulfonate 10 g, sodium dodecyl sulfate 4 g, attractant composition (attractant cis-9-tricosene) 3.8 g, kaolin to make 100 g. A wettable powder was prepared by the above method.

[0071] Preparation Example 14: 42% cyflumetofen·flupyradifurone wettable powder

[0072] Cyflumetofen 2 g, flupyradifurone 40 g, sodium lignosulfonate 12 g, sodium dodecyl sulfate 5 g, attractant composition (attractant cis-9-tricosene) 5 g, kaolin to make 100 g. A wettable powder was prepared by the above method.

[0073] Preparation Example 15: 15% cyflumetofen·chlorothalonil wettable powder

[0074] Cyflumetofen 5 g, chlorothalonil 10 g, sodium salt of methylnaphthalenesulfonic acid formaldehyde condensate 18 g, sodium dodecyl sulfate 6 g, attractant composition (attractant cis-9-tricosene) 3.8 g, kaolin to make 100 g. A wettable powder was prepared by the above method.

[0075] Preparation Example 16: 35% cyflumetofen·lothiclarb wettable powder

[0076] Cycloprothrin 5 g, thiacloprid 30 g, sodium lignosulfonate 12 g, sodium dodecyl sulfate 4 g, attractant composition (attractant cis-9-tricosene) 4 g, kaolin to 100 g. Wettable powder was prepared by the above-mentioned method.

[0077] Formulation Example 17: 60% cycloprothrin · dinotefuran water dispersible granule

[0078] Cycloprothrin 20 g, dinotefuran 40 g, sodium lignosulfonate 5 g, sodium polycarboxylate 5 g, sodium sulfate 1 g, ammonium sulfate 3 g, attractant composition (attractant cis-9-tricosene) 5 g, corn starch to 100 g. Water dispersible granule was prepared by the above-mentioned method.

[0079] Formulation Example 18: 20% cycloprothrin · imidacloprid water dispersible granule

[0080] Cycloprothrin 5 g, imidacloprid 15 g, sodium lignosulfonate 5 g, sodium polycarboxylate 12 g, sodium sulfate 1 g, ammonium sulfate 1 g, attractant composition (attractant butter essence) 2 g, light calcium 6 g, diatomite to 100 g. Water dispersible granule was prepared by the above-mentioned method.

[0081] Formulation Example 19: 30% cycloprothrin · acetamiprid water dispersible granule

[0082] Cycloprothrin 10 g, acetamiprid 20 g, sodium lignosulfonate 8 g, sodium polycarboxylate 2 g, sodium carbonate 4 g, sodium bicarbonate 4 g, attractant composition (attractant cis-9-tricosene) 3 g, kaolin to 100 g. Water dispersible granule was prepared by the above-mentioned method.

[0083] Formulation Example 20: 25% cycloprothrin · thiacloprid water dispersible granule

[0084] Cycloprothrin 5 g, thiacloprid 20 g, sodium lignosulfonate 8 g, sodium polycarboxylate 5 g, sodium carbonate 2 g, sodium bicarbonate 2 g, attractant composition (attractant cis-9-tricosene) 4 g, diatomite to 100 g. Water dispersible granule was prepared by the above-mentioned method.

[0085] Formulation Example 21: 40% cycloprothrin · thiamethoxam water dispersible granule

[0086] Cycloprothrin 20 g, thiamethoxam 20 g, methylnaphthalene sulfonate formaldehyde condensate sodium salt 5 g, sodium polycarboxylate 5 g, sodium chloride 6 g, attractant composition (attractant cis-9-tricosene) 5 g, calcium carbonate 5 g, corn starch to 100 g. Water dispersible granule was prepared by the above-mentioned method.

[0087] Formulation Example 22: 30% cycloprothrin · spirodiclofen water dispersible granule

[0088] Cyflumetofen 5 g, fluazuron 25 g, sodium salt of alkyl naphthalene sulfonate formaldehyde polycondensate 4 g, sodium salt of methyl naphthalene sulfonate formaldehyde polycondensate 4 g, sodium salt of polycarboxylic acid 10 g, sodium chloride 6 g, attractant composition (attractant cis-9-tricosene) 5 g, light calcium 4 g, attapulgite to make up to 100 g. Water dispersible granules were prepared by the above method.

[0089] Preparation Example 23: 20% cyflumetofen · chlorothalonil water dispersible granules

[0090] Cyflumetofen 15 g, chlorothalonil 5 g, sodium salt of lignin sulfonate 6 g, fatty amine polyoxyethylene ether 10 g, sodium chloride 6 g, attractant composition (attractant cis-9-tricosene) 3.8 g, light calcium 4 g, attapulgite to make up to 100 g. Water dispersible granules were prepared by the above method.

[0091] Preparation Example 24: 25% cyflumetofen · nitenpyram water dispersible granules

[0092] Cyflumetofen 5 g, nitenpyram 20 g, sodium salt of lignin sulfonate 6 g, fatty alcohol polyoxyethylene ether 10 g, sodium chloride 6 g, attractant composition (attractant cis-9-tricosene) 3.8 g, light calcium 4 g, attapulgite to make up to 100 g. Water dispersible granules were prepared by the above method.

[0093] Preparation Example 25: 60% cyflumetofen · dinotefuran dry suspension

[0094] Cyflumetofen 20 g, dinotefuran 40 g, sodium salt of lignin sulfonate 5 g, sodium salt of polycarboxylic acid 5 g, attractant composition (attractant brown sugar) 5 g, corn starch to make up to 100 g. Dry suspension was prepared by the above method.

[0095] Preparation Example 26: 20% cyflumetofen · imidacloprid dry suspension

[0096] Cyflumetofen 5 g, dinotefuran 15 g, sodium salt of lignin sulfonate 2.5 g, sodium salt of polycarboxylic acid 8 g, attractant composition (attractant cis-9-tricosene) 3 g, light calcium 6 g, diatomite to make up to 100 g. Dry suspension was prepared by the above method.

[0097] Preparation Example 27: 30% cyflumetofen · acetamiprid dry suspension

[0098] Cyflumetofen 10 g, acetamiprid 20 g, sodium salt of lignin sulfonate 8 g, sodium salt of polycarboxylic acid 2 g, attractant composition (attractant cis-9-tricosene) 4 g, kaolin to make up to 100 g. Dry suspension was prepared by the above method.

[0099] Preparation Example 28: 25% cyflumetofen · thiacloprid dry suspension

[0100] Chlorfenapyr 20 g, Sodium lignosulfonate 8 g, Sodium polycarboxylate 5 g, Attractant composition (attractant cis-9-tricosene) 3 g, Diatomite to 100 g. Dry suspension concentrate was prepared by the above method.

[0101] Preparation Example 29: 40% chlorfenapyr·thiamethoxam dry suspension

[0102] Chlorfenapyr 20 g, Thiamethoxam 20 g, Sodium methyl naphthalene sulfonate formaldehyde condensate 4 g, Sodium polycarboxylate 5 g, Attractant composition (attractant cis-9-tricosene) 4 g, Calcium carbonate 5 g, Corn starch to 100 g. Dry suspension concentrate was prepared by the above method.

[0103] Preparation Example 30: 30% chlorfenapyr·fluopyram dry suspension

[0104] Chlorfenapyr 5 g, Fluopyram 25 g, Sodium alkyl naphthalene sulfonate formaldehyde condensate 4 g, Sodium methyl naphthalene sulfonate formaldehyde condensate 4 g, Sodium polycarboxylate 8 g, Attractant composition (attractant cis-9-tricosene) 5 g, Light calcium 4 g, Attapulgite to 100 g. Dry suspension concentrate was prepared by the above method.

[0105] Preparation Example 31: 20% chlorfenapyr·chlorothalonil dry suspension

[0106] Chlorfenapyr 15 g, Chlorothalonil 5 g, Sodium lignosulfonate 6 g, Fatty amine polyoxyethylene ether 4 g, Attractant composition (attractant cis-9-tricosene) 2 g, Light calcium 4 g, Attapulgite to 100 g. Dry suspension concentrate was prepared by the above method.

[0107] Preparation Example 32: 25% chlorfenapyr·lothianidin dry suspension

[0108] Chlorfenapyr 5 g, Clothianidin 20 g, Sodium lignosulfonate 6 g, Fatty alcohol polyoxyethylene ether 5 g, Attractant composition (attractant cis-9-tricosene) 3 g, Light calcium 4 g, Attapulgite to 100 g. Dry suspension concentrate was prepared by the above method.

[0109] Comparative Example 1: 8% chlorfenapyr suspension

[0110] Chlorfenapyr 8 g, Sodium polycarboxylate 4 g, Modified rosin polyether phosphate 5 g, Propylene glycol 5 g, Potassium sorbate 0.5 g, Citric acid 0.1 g, Magnesium aluminum silicate 0.5 g, Xanthan gum 0.3 g, Silicone oil 0.2 g, Attractant composition (attractant brown sugar) 2 g, Deionized water to 100 g. Suspension was prepared by the above method.

[0111] Comparative Example 2: 40% dinotefuran wettable powder

[0112] Fipronil 40 g, sodium lignosulfonate 10 g, sodium dodecyl sulfate 5 g, attractant composition (attractant red sugar) 2 g, kaolin to 100 g. The wettable powder was prepared according to the above method.

[0113] Comparative Example 3: 15% imidacloprid water dispersible granule

[0114] Imidacloprid 15 g, sodium lignosulfonate 5 g, sodium polycarboxylate 12 g, sodium sulfate 1 g, ammonium sulfate 1 g, light calcium 6 g, diatomite to 100 g. The water dispersible granule was prepared according to the above method.

[0115] Comparative Example 4: 40% fipronil dry flowable concentrate

[0116] Fipronil 40 g, sodium lignosulfonate 5 g, sodium polycarboxylate 5 g, attractant composition (attractant red sugar) 5 g, corn starch to 100 g. The dry flowable concentrate was prepared according to the above method.

[0117] Comparative Example 5: 15% cyromazine·fipronil suspension concentrate

[0118] Cyromazine 5 g, fipronil 10 g, fatty acid polyoxyethylene ether 7 g, fatty alcohol polyoxyethylene ether sodium sulfonate 1 g, propylene glycol 7 g, potassium sorbate 0.3 g, citric acid 0.3 g, magnesium aluminum silicate 1 g, xanthan gum 0.4 g, glyceryl ricinoleate 1 g, deionized water to 100 g. The suspension concentrate was prepared according to the above method.

[0119] Comparative Example 6: 80% cyromazine·fipronil wettable powder

[0120] Cyromazine 40 g, fipronil 40 g, sodium lignosulfonate 10 g, sodium dodecyl sulfate 5 g, kaolin to 100 g. The wettable powder was prepared according to the above method.

[0121] Comparative Example 7: 20% cyromazine·imidacloprid water dispersible granule

[0122] Cyromazine 5 g, imidacloprid 15 g, sodium lignosulfonate 5 g, sodium polycarboxylate 12 g, sodium sulfate 1 g, ammonium sulfate 1 g, light calcium 6 g, diatomite to 100 g. The water dispersible granule was prepared according to the above method.

[0123] The technical effects of the present application are described below in conjunction with specific tests:

[0124] Verification Test 1: Co-toxicity coefficient test

[0125] (1) Test object: housefly (laboratory breeding)

[0126] (2) Test method: Refer to GB / T26350-2010 "Housefly resistance detection method housefly bioassay method" and NY / T1154.7-2006 "Pesticide indoor biological determination test standard insecticide part 7: mixed joint action determination"

[0127] (3) Data statistics: First, the test agent is dissolved with dichloromethane, then diluted with 0.1% Triton-X100 aqueous solution at a ratio of 1:9, 1 mL of each dilution concentration of the drug solution is added to a 150 mL serum bottle, the serum bottle is constantly rotated to make the drug solution evenly distributed on the inner wall of the bottle, and the bottle is placed in a fume hood overnight to make the organic solvent volatilize completely. The concentration interval of 100% death and 100% survival of the test insects is determined. Appropriate concentration is taken in the interval, and series of dilution is carried out with 0.1% Triton-X100 aqueous solution. 1 mL of each dilution concentration of the drug solution is added to a 150 mL serum bottle, the serum bottle is constantly rotated to make the drug solution evenly distributed on the inner wall of the bottle, and the bottle is placed in a fume hood overnight to make the organic solvent volatilize completely. Then vaseline is smeared on the bottle neck of the serum bottle, 20 test insects are put into each bottle, and the experiment is repeated 5 times. The corresponding solvent treatment is used as the control group. After 1 h, all the test insects are transferred to clean vessels for standard feeding, and the number of deaths is checked and counted after 24 h. Statistical analysis software SPSS is used for analysis, and the LC 50 and 95% confidence limit values of each pesticide are calculated. The determination results are shown in the following table:

[0128] Table 1 Co-toxicity coefficient of cyromazine and imidacloprid to housefly

[0129]

[0130]

[0131] From Table 1, it can be seen that when the complexing ratio of cyromazine:imidacloprid is 10:1 to 2:1, the co-toxicity coefficient to housefly is greater than 100 and less than 120, showing additive effect; when the complexing ratio of cyromazine:imidacloprid is 1:1 to 1:20, the co-toxicity coefficient to housefly is greater than 120, showing obvious synergistic effect.

[0132] Table 2 Co-toxicity coefficient of cyromazine and dinotefuran to housefly

[0133]

[0134] From Table 2, it can be seen that when the complexing ratio of cyromazine:imidacloprid is 10:1 to 2:1, the co-toxicity coefficient to housefly is greater than 100 and less than 120, showing additive effect; when the complexing ratio of cyromazine:imidacloprid is 1:1 to 1:20, the co-toxicity coefficient to housefly is greater than 120, showing obvious synergistic effect.

[0135] The optimum ratio and co-toxicity coefficient of cyromazine and neonicotinoid insecticides are shown in Table 3 below:

[0136] Table 3 Co-toxicity coefficient of cyromazine and neonicotinoid insecticides on Musca domestica

[0137]

[0138] Verification test 2: retention efficacy test for controlling flies

[0139] (1) Test object: Musca domestica

[0140] (2) Test method: Retention spray test according to GB / T 13917.1-2009 Indoor efficacy test and evaluation of hygienic insecticides for pesticide registration.

[0141] (3) Test agents:

[0142] Comparative example 1: 70% imidacloprid water dispersible granules (commercially available)

[0143] Comparative example 2: 40% dinotefuran soluble granules (commercially available)

[0144] Preparation examples 1-35 were diluted with water to 800 ppm, and comparative examples 1-4 and comparative examples 1-2 were diluted with water to 800 ppm.

[0145] (4) Data statistics:

[0146] Table 4 Efficacy test results of several treatments on Musca domestica

[0147]

[0148]

[0149] The test results show that the preferred ratio of the compound agent has a mortality rate of 80% to 100% on Musca domestica, and the effect is obvious.

[0150] Verification test 3: attraction effect test of the attractant composition

[0151] (1) Test object: Musca domestica

[0152] (2) Test method: Retention spray test according to GB / T 13917.1-2009 Indoor efficacy test and evaluation of hygienic insecticides for pesticide registration.

[0153] (3) Test agents:

[0154] Comparative examples 5, 6, and 7 were diluted with water to 800 ppm, and preparation examples 5, 10, and 18 were diluted with water to 800 ppm.

[0155] (4) Data statistics:

[0156] Table 5 Results of efficacy test of several treatments on Musca domestica

[0157] treatment group target 24h mortality formulation example 5 housefly 90.0％ comparative example 5 housefly 76.7％ formulation example 10 housefly 96.7％ comparative example 6 housefly 86.7％ formulation example 18 housefly 100.0％ comparative example 7 housefly 83.3％

[0158] The test results show that the mortality of the agent added with the attractant composition is higher than that of the agent without the attractant composition.

[0159] The above examples are only for illustrating the technical concept and technical features of the present application, and cannot limit the protection scope of the present application. Any equivalent transformation or modification according to the essence of the present application should be covered in the protection scope of the present application.

Claims

1. Use of a binary hygiene insecticidal composition containing cycloprothrin for controlling flies in the hygiene sector, characterized in that: The effective component of the binary hygiene insecticidal composition containing cycloprothrin includes cycloprothrin and neonicotinoid insecticide, the total weight of cycloprothrin and neonicotinoid insecticide accounts for 2-80% of the total weight of the hygiene insecticidal composition, and the rest is auxiliary material; The neonicotinoid insecticide is any one of imidacloprid, acetamiprid, thiacloprid, thiamethoxam, dinotefuran, flupyradifurone, chlorocholine chloride and nitenpyram; the weight ratio of cycloprothrin and neonicotinoid insecticide is 1:1-1:20; The auxiliary material is an auxiliary agent and an attracting composition, wherein the auxiliary agent is a mixture of three or more of wetting agent, dispersing agent, filler, antifreezing agent, preservative, defoaming agent, thickening agent, PH regulator, deionized water and disintegrating agent in any proportion; The attracting composition includes the following raw materials in percentage by weight: agar 5%, sorbitol 5%, attractant 60%, propylene glycol 5%, xanthan gum 0.5%, magnesium aluminum silicate 0.5-1% and deionized water in the rest; The flies refer to housefly, Muscina stabulans, Fannia scalaris, Fannia canicularis, Muscina assimilis, Phaenicia coeruleifrons, Phaenicia sericata, Phaenicia lugubris, Phaenicia claripalpis, Calliphora erythrocephala, Aldrichina grahami, Fannia scalaris and Fannia canicularis.

2. Use according to claim 1, characterized in that: The binary hygiene insecticidal composition is in the form of wettable powder, suspension concentrate, water dispersible granule or dry suspension.

3. Use according to claim 2, characterized in that: When the binary hygiene insecticidal composition is in the form of wettable powder, it includes the following raw materials in percentage by weight: 1-40% of cycloprothrin, 1-40% of neonicotinoid insecticide, 2-6% of wetting agent, 7-18% of dispersing agent, 2-5% of attracting composition, and the rest is filler.

4. Use according to claim 2, characterized in that: When the binary hygiene insecticidal composition is in the form of suspension concentrate, it includes the following raw materials in percentage by weight: 1-20% of cycloprothrin, 1-20% of neonicotinoid insecticide, 1-8% of wetting agent, 1-20% of dispersing agent, 3-7% of antifreezing agent, 0.3-2% of preservative, 0.1-1% of defoaming agent, 0.5-3% of thickening agent, 0.1-0.5% of PH regulator, 2-5% of attracting composition, and the rest is deionized water.

5. Use according to claim 2, characterized in that: When the binary hygiene insecticidal composition is in the form of water dispersible granule, it includes the following raw materials in percentage by weight: 1-40% of cycloprothrin, 1-40% of neonicotinoid insecticide, 2-12% of wetting agent, 5-18% of dispersing agent, 2-8% of disintegrating agent, 2-5% of attracting composition, and the rest is filler.

6. Use according to claim 2, characterized in that: When the binary hygiene insecticidal composition is in the form of dry suspension, it includes the following raw materials in percentage by weight: 1-20% of component A, 1-40% of component B, 1-8% of wetting agent, 1-8% of dispersing agent, 2-5% of attracting composition, and the rest is filler.

7. Use according to claim 1, characterized in that: The bait composition is prepared by the following method: weighing agar, sorbitol, attractant, propylene glycol, xanthan gum and water in proportion, heating to swelling state, then adding 0.5% magnesium aluminum silicate, stirring uniformly to obtain a wet gel-like bait composition; by the same method, when the amount of magnesium aluminum silicate is 1%, the wet gel-like bait composition is naturally dried or oven dried to obtain a dry gel-like bait composition; the wet gel-like bait composition is directly added as a suspension agent; the dry gel-like bait composition is used as a wettable powder, a water dispersible granule or a dry suspension agent after being pulverized by airflow.

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