An insecticide aerosol

Abstract

The invention discloses an insecticidal aerosol, comprising the following components in weight percentage: 0.01%-4% of an active ingredient, 0.1%-70% of a solvent, 26%-90% of a propellant, and 2%-10% of a plant essential oil; the active ingredient is a piperic acid derivative compound represented by formula I; the insecticidal aerosol composition of the invention has the advantages of fast knockdown speed and high mortality rate against pests such as mosquitoes, flies, and German cockroaches.

Description

Technical Field

[0001] The present invention relates to an insecticide aerosol, in particular to an insecticide aerosol containing a piperic acid derivative compound, which is used for preventing and controlling sanitary pests such as mosquitoes, flies, and German cockroaches. Background Art

[0002] Currently, pyrethroid compounds are still the main ingredients in the aerosol market. However, with years of use, sanitary pests such as mosquitoes, flies, or German cockroaches have developed resistance to some traditional insecticides, resulting in a decrease in prevention effectiveness.

[0003] Chinese invention patent CN112457288 discloses a piperic acid derivative and its applications, including compound I-72, which exhibits contact and stomach toxicity, as well as good conduction activity. Compound I-72 has not been used in aerosol formulations to date. It exhibits high knockdown and lethal activity, yet exhibits low toxicity. This high activity reduces the amount of active ingredient used per unit area, aligning with national policies on increasing efficiency and reducing application. This is the first aerosol formulation developed for use, which reduces drug resistance in vector-borne organisms and improves their effectiveness in controlling disease vectors. The compound's structural formula is as follows:

[0004]

[0005] By adding plant essential oils to aerosols, the permeability and adhesion of spray droplets to sanitary pests are improved, and the utilization rate of pesticides is improved by increasing the efficacy. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to address the deficiencies in the prior art and to provide an insecticidal aerosol. The aerosol contains a piperic acid derivative compound (compound I-72) as a main component and has a very good control effect on sanitary pests such as mosquitoes, flies, German cockroaches, American cockroaches, bedbugs, ants, and fleas. Also provided are a preparation method of the insecticidal aerosol and its application in controlling sanitary pests.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] An insecticide aerosol comprising the following components in weight percentage: 0.01%-4% active ingredient, 0.1%-70% solvent, 26%-90% propellant, and 2%-10% plant essential oil; the active ingredient is a piperic acid derivative compound represented by Formula I (referred to as Compound I-72);

[0009]

[0010] In the above technical solution, the solvent is any one of C8-18 alkane solvents, amide solvents, monoester solvents, diester solvents, alcohol ether solvents, C2-8 alcohol solvents, water, dodecylbenzene, decaalkylbenzene, or a mixture of two or more of the solvents in any proportion, wherein:

[0011] The C8-18 alkane solvent is preferably D60 (ExxonMobil Petrochemical Company), D80 (ExxonMobil Petrochemical Company), D100 (ExxonMobil Petrochemical Company), D110 (ExxonMobil Petrochemical Company), Isopar-E (ExxonMobil Petrochemical Company), Isopar-G (ExxonMobil Petrochemical Company), Isopar-H (ExxonMobil Petrochemical Company), Isopar-L (ExxonMobil Petrochemical Company), Isopar-M (ExxonMobil Petrochemical Company), any one of octane, nonane, quinane, undecane, dodecane, tridecane, tetradecane, pentadecane, and hexadecane, or a mixture of two or more in any proportion.

[0012] The amide solvent is preferably N, N-dimethyl amide;

[0013] The monoester solvent is preferably γ-butyrolactone; any one of methyl oleate, isopropyl tridecanoate, isopropyl myristate, isopropyl hexadecanoate, isopropyl phenylacetate, ethyl phenylacetate, and n-butyl myristate, or a mixture of two or more of the above in any proportion;

[0014] The diester solvent is preferably any one of diisopropyl glutarate, diisopropyl adipate, and diisobutyl adipate, or a mixture of two or more of the above in any proportion;

[0015] The alcohol ether solvent is preferably a triester solvent such as tributyl citrate, acetyl tributyl citrate, or any one of triethylene glycol monobutyl ether, diethylene glycol monobutyl ether, propylene glycol methyl ether, and dipropylene glycol propyl ether, or a mixture of two or more of the above in any proportion;

[0016] The C2-8 alcohol solvent is preferably any one of ethanol, isopropanol, n-propanol, n-butanol, sec-butanol, tert-butanol, n-pentanol and its isomers, n-hexanol and its isomers, n-heptanol and its isomers, n-octanol and its isomers, or a mixture of two or more in any proportion.

[0017] In the above technical solution, the propellant is any one of liquefied petroleum gas, propane, butane, dimethyl ether or compressed air.

[0018] In the above technical solution, the plant essential oil is any one of artemisia oil, cottonseed oil, pepper oil, citronella oil, clove oil and geranium oil.

[0019] In the above technical solution, the insecticide aerosol may further include a pyrethroid compound, and the weight ratio of the pyrethroid compound to the piperic acid derivative compound is 2:1 to 1:3.

[0020] In the above technical solution, the pyrethroid is any one of transfluthrin, transfluthrin, d-trans chlorpropamide, and bio-allethrin.

[0021] The present invention also provides a method for preparing the insecticidal aerosol, comprising the following steps: mixing the piperic acid derivative compound, solvent, and plant essential oil (and pyrethroid compound) in the stated proportions at room temperature or under heating (20°C-50°C), adding the mixture into a spray can with a common spray valve or a control valve (valve volume 0.02ml-1ml), and adding a propellant into the can under pressure through the control valve to obtain the insecticidal aerosol.

[0022] The present invention also provides an application of the insecticide aerosol in preventing and controlling sanitary pests.

[0023] In the above technical solution, the sanitary pests refer to mosquitoes, flies, German cockroaches, American cockroaches, bedbugs, ants, fleas, bees, etc.

[0024] In the above technical solution, when the insecticide aerosol is used to control sanitary pests, it is applied by spraying 2 or more times in a certain space through a control valve. The number of sprays is determined according to the size of the space, and an average of 1 spray per 5m3.

[0025] The insecticidal aerosol of the present invention, when in use, generates a high-speed airflow by opening the control valve and, under the pressure of the propellant, utilizing the vaporization energy of the propellant to disperse and atomize the active ingredient liquid in the tank, forming small mist droplets suspended in the air. The droplets then come into contact with sanitary pests such as mosquitoes, flies, and cockroaches, thereby achieving the purpose of rapidly controlling and killing the pests. Efficacy experiments have demonstrated that the insecticidal aerosol of the present invention exhibits rapid knockdown and a high mortality rate against sanitary pests such as Culex pipiens pallens, houseflies, and German cockroaches, achieving superior control efficacy compared to a control agent. DETAILED DESCRIPTION

[0026] The following describes in detail the specific implementation of the technical solution of the present invention, but the present invention is not limited to the following description:

[0027] The preparation method of the dosage form in each embodiment of the present invention is as follows: Compound I-72, solvent, plant essential oil and pyrethroid compound in the stated proportions are mixed at room temperature and added to a spray tank equipped with a control valve, and a propellant is added to the tank under pressure through the control valve to prepare the preparation.

[0028] The present invention will be described below in conjunction with specific embodiments:

[0029] Formulation Example 1: 0.3% Compound I-72 Aerosol

[0030] Compound I-720.3g, artemisia oil 2g, diisopropyl adipate 42.7g, propane-butane 55g, were used to prepare an aerosol according to the above method.

[0031] Formulation Example 2: 0.3% Compound I-72 Aerosol

[0032] Compound I-720.3g, citronella oil 4g, dipropylene glycol propyl ether 10g, ethanol 20.7g, n-butanol 10g, liquefied petroleum gas 55g, were used to prepare an aerosol according to the above method.

[0033] Formulation Example 3: 0.4% Compound I-72 Aerosol

[0034] Compound I-720.4g, Zanthoxylum bungeanum oil 5g, dipropylene glycol propyl ether 10g, ethanol 58.6g, propane-butane 26g, were used to prepare an aerosol according to the above method.

[0035] Formulation Example 4: 0.4% Compound I-72 Aerosol

[0036] Compound I-720.4g, geranium oil 6g, D11040.6g, propane-butane 53g, were used to prepare an aerosol according to the above method.

[0037] Formulation Example 5: 0.5% Compound I-72 Aerosol

[0038] Compound I-720.5g, citronella oil 5g, D11044.5g, liquefied petroleum gas 50g, were used to prepare an aerosol according to the above method.

[0039] Formulation Example 6: 0.5% Compound I-72 Aerosol

[0040] Compound I-720.5g, D8030.5g, Isopar-M 10g, citronella oil 9g, propane-butane 50g, were used to prepare an aerosol according to the above method.

[0041] Formulation Example 7: 0.6% Compound I-72 Aerosol

[0042] Compound I-720.6g, cottonseed oil 5g, Isopar-E 34.4g, Isopar-L 15g, propane-butane 45g, were used to prepare an aerosol according to the above method.

[0043] Formulation Example 8: 0.6% Compound I-72 Aerosol

[0044] Compound I-720.6g, cottonseed oil 5g, D8023.4g, D11021g, propane 50g, and butane were used to prepare an aerosol according to the above method.

[0045] Formulation Example 9: 0.7% Compound I-72 Aerosol

[0046] Compound I-720.7g, artemisia oil 2g, dipropylene glycol propyl ether 14.3g, diisopropyl adipate 28g, water 5g, propane-butane 50g, were used to prepare an aerosol according to the above method.

[0047] Formulation Example 10: 0.7% Compound I-72 Aerosol

[0048] Compound I-720.7g, geranium oil 5g, dipropylene glycol propyl ether 14g, ethanol 30.3g, liquefied petroleum gas 50g, were used to prepare an aerosol according to the above method.

[0049] Formulation Example 11: 0.7% Compound I-72 Aerosol

[0050] Compound I-720.7g, geranium oil 5g, dipropylene glycol propyl ether 15g, isopropyl alcohol 14.3g, water 10g, propane-butane 55g, were used to prepare an aerosol according to the above method.

[0051] Formulation Example 12: 0.01% Compound I-72 Aerosol

[0052] Compound I-720.01g, clove oil 2g, D6024.99g, D8023g, propane 50g, and butane were used to prepare an aerosol according to the above method.

[0053] Formulation Example 13: 0.1% Compound I-72 Aerosol

[0054] Compound I-7 20.1g, pepper oil 2g, diisopropyl adipate 27.9g, D110 20g, propane-butane 50g, were used to prepare an aerosol according to the above method.

[0055] Formulation Example 14: 0.15% Compound I-72 Aerosol

[0056] Compound I-720.15g, bio-allethrin 0.05g, geranium oil 5g, dipropylene glycol propyl ether 15g, n-butanol 6.8g, ethanol 15g, water 8g, propane-butane 50g, were used to prepare an aerosol according to the above method.

[0057] Formulation Example 15: 0.2% Compound I-72 Aerosol

[0058] Compound I-720.2g, tetrafluthrin 0.1g, artemisia oil 6g, diisopropyl adipate 21.7g, D11022g, dimethyl ether 50g, an aerosol was prepared according to the above method.

[0059] Formulation Example 16: 1.0% Compound I-72 Aerosol

[0060] Compound I-721.0g, D-trans-chlorpromazine 0.2g, Zanthoxylum bungeanum oil 5g, diisopropyl adipate 28.8g, D11020g, and dimethyl ether 45g were used to prepare an aerosol according to the above method.

[0061] Formulation Example 17: 1.0% Compound I-72 Aerosol

[0062] Compound I-721.0g, pepper oil 5g, diisopropyl adipate 29g, D11020g, dimethyl ether 45g, an aerosol was prepared according to the above method.

[0063] Formulation Example 18: 2.0% Compound I-72 Aerosol

[0064] Compound I-7 22g, clove oil 8g, Isopar-E 24g, Isopar-L 21g, propane 45g, an aerosol was prepared according to the above method.

[0065] Formulation Example 19: 3.0% Compound I-72 Aerosol

[0066] Compound I-723g, artemisia oil 7g, diisopropyl adipate 25g, D11015g, dimethyl ether 50g, were used to prepare an aerosol according to the above method.

[0067] Formulation Example 20: 4.0% Compound I-72 Aerosol

[0068] Compound I-724g, clove oil 10g, diisopropyl adipate 10g, dodecylbenzene 20g, D1106g, liquefied petroleum gas 50g, an aerosol was prepared according to the above method.

[0069] Comparative Example 1: 0.4% Compound I-72 Aerosol

[0070] Compound I-720.4g, D11046.6g, propane 53g, and butane were used to prepare an aerosol according to the above method.

[0071] Comparative Example 2: 0.5% Compound I-72 Aerosol

[0072] Compound I-720.5g, D11049.5g, liquefied petroleum gas 50g, and an aerosol were prepared according to the above method.

[0073] Comparative Example 3: 0.5% Compound I-72 Aerosol

[0074] Compound I-720.5g, D8039.5g, Isopar-M 10g, propane 50g, and butane were used to prepare an aerosol according to the above method.

[0075] Control agent 1: 0.6% tetramethrin-permethrin aerosol (commercially available, composed of 0.3% tetramethrin + 0.3% permethrin)

[0076] Verification test 1: Cylindrical aerosol efficacy test

[0077] Test agents: Preparation Examples 1, 4, 5, 6, 7, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 of the present invention, Comparative Example 1, Comparative Example 2, Comparative Example 3 and Control Agent 1

[0078] Test insects: Culex pipiens, female adults that have not fed blood on the 3rd to 5th day after emergence

[0079] Housefly, adult flies 3-4 days after emergence, half male and half female

[0080] German cockroaches, 10-15 day old adults, half male and half female

[0081] Test method: Refer to GB / T 13917.2-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration Part 2: Aerosol method.

[0082] Mosquitoes and flies: Use a cylinder device. The specific method is to put the test insects (30 houseflies, or 30 mosquitoes) into the cylinder. After the test insects resume normal activities, place the aerosol cylinder to be tested horizontally, with the nozzle pointing vertically downward, aiming at the spray hole, spray the agent (1.0±0.1g), and immediately plug the round hole with a rubber stopper (G). After 1 minute, remove the pull plate (A), start the time immediately, and record the number of knocked-down test insects at regular intervals. After 20 minutes, move the knocked-down test insects to a clean insect cage, restore the feeding standard, and feed them with 5% sugar water cotton balls. Check the number of dead insects for 24 hours, and the test insects that have not been knocked down will be counted as live insects. The test should be repeated three times or more. The test device should be cleaned after each test.

[0083] Cockroaches: Use a cylindrical device without pulling the plate. Place 20 German cockroaches in a cylinder B with a circle of vaseline on the upper part of the inner wall and a 12-mesh iron screen at the bottom. After the test insects resume normal activities, place the aerosol cylinder horizontally, with the nozzle pointing vertically downward at the spray hole on E, spray the agent (1.0±0.1g), immediately plug the round hole with a rubber stopper (G), start timing, and record the number of knocked-down test insects at regular intervals. After 20 minutes, transfer all the test insects to a clean container and resume standard feeding. Feed with mixed feed blocks and soaked cotton balls, and check the number of dead insects for 72 hours. The test should be repeated three times or more. After each test, the test device should be cleaned. The detailed results are shown in the following table:

[0084] Table 1 Results of the efficacy test of the above aerosols against Culex pipiens, housefly and German cockroach

[0085]

[0086]

[0087] As can be seen from Table 1, the aerosol of the present invention has a good killing effect on Culex pipiens pallens, housefly and German cockroach.

[0088] The above examples are only for illustrating the technical concept and technical features of the present invention and are not intended to limit the scope of protection of the present invention. Any equivalent transformation or modification made based on the essence of the present invention should be included in the scope of protection of the present invention.

Claims

1. An insecticide aerosol, characterized in that: The composition comprises the following components in weight percentage: 0.01%-4% active ingredient, 0.1%-70% solvent, 26%-90% propellant, and 2%-10% plant essential oil; the active ingredient is a piperic acid derivative compound shown in the following formula: The plant essential oil is any one of artemisia oil, cottonseed oil, pepper oil, citronella oil, clove oil and geranium oil.

2. The insecticide aerosol according to claim 1, characterized in that The solvent is any one of C8-18 alkane solvents, amide solvents, monoester solvents, diester solvents, alcohol ether solvents, C2-8 alcohol solvents, water, dodecylbenzene, decaalkylbenzene, or a mixture of two or more of the solvents in any proportion.

3. The insecticide aerosol according to claim 1, characterized in that The propellant is any one of liquefied petroleum gas, propane, butane, dimethyl ether or compressed air.

4. The insecticide aerosol according to claim 1, characterized in that The insecticide aerosol may further include pyrethroid compounds, wherein the weight ratio of pyrethroid compounds to piperic acid derivative compounds is 2:1 to 1:3; the pyrethroid is any one of transfluthrin, transfluthrin, d-trans chlorpropamide, and bio-allethrin.

5. Use of the insecticide aerosol according to any one of claims 1 to 4 in controlling sanitary pests, characterized in that: The sanitary pests are mosquitoes, flies, German cockroaches and American cockroaches.

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