Application of fullerene to improvement of discomforting period of cats in changing food

Abstract

The invention discloses an application of fullerene in improving the uncomfortable period of changing food for cats. Fullerene has the effect of relieving the conditions of diarrhea, vomiting and anorexia when cats change food.

Description

Technical Field

[0001] The invention relates to the field of feed, and in particular to the use of fullerene in improving the discomfort period of cats when changing food. Background Art

[0002] The Pet Health Center of the School of Veterinary Medicine at the University of California, Davis, found through research that although it is not so common for cat food on the market to be malnourished or over-nourished nowadays, only serious defects have been reduced, and minor problems still occur from time to time. Another problem with commercial cat food is that it is easy to cause adverse reactions, especially "inflammatory bowel disease" (IBD). By comparing experiments in which cats were fed raw rabbit meat and high-quality commercial cat food, scientists found that a single diet or a single cat food could not maintain the best intestinal health of cats. Only a diversified diet is the best model. Therefore, cats should be given as many different foods as possible from an early age, including various good brands of cat food, wet food and freeze-dried food, as well as different formulas of the same brand, so that they can continue to maintain the diversified dietary nature left by their ancestors. So, how often should cats change their cat food? There is not enough scientific experimental evidence to draw a conclusion, but experts have concluded that three or four months may be the most ideal time interval, and it is necessary to change it at least once every six months. This is based on the environment faced by the cat's ancestors, the wild cats. In the wild, cats' prey changes usually depend on the "seasonal" conditions in nature. For example, there may be more of a certain animal in a certain season, and cats will use them as their main food. The conditions in nature usually depend on the season, and they will change significantly every three or four months. Therefore, experts speculate that cats' digestive systems are more accustomed to a frequency of changes every three or four months. Perhaps not coincidentally, modern cat food is usually packaged in large packages that are eaten in three to four months to half a year, which may be due to this reason. Therefore, there is a conclusion that cat food should be changed at least once every six months, otherwise it may be detrimental to gastrointestinal health. It must be reminded that there is not enough scientific evidence to confirm this view, but from a theoretical point of view, this arrangement is not a problem.

[0003] However, cats' stomachs are relatively fragile, especially those of some more expensive cat breeds. A 7-day transition period is currently recommended during the food change process. Even so, many cats will still experience food discomfort, manifested as diarrhea, hair loss, anorexia, vomiting, bad temper, and depression. One or more of these symptoms. Summary of the invention

[0004] Based on the above problems, the purpose of the present invention is to provide a new use of fullerene for improving the discomfort period of cats when changing food.

[0005] The present invention provides a new use of fullerene to improve the discomfort period of cats changing food;

[0006] Furthermore, the improvement of the cat's discomfort period when changing food is to reduce diarrhea, vomiting and anorexia when the cat changes food.

[0007] Furthermore, the use is as a feed additive for improving the discomfort period of cats during food change.

[0008] Furthermore, the fullerene is fullerene C60, C60 derivatives, or a water-soluble and oil-soluble mixture of C60.

[0009] The present invention also provides a method for improving the discomfort period of cats when changing food, which is characterized by feeding a feed additive containing fullerene.

[0010] The present invention has tested that fullerene can realize easy food change for cats, especially for problems such as diarrhea, vomiting, and anorexia. When the food is changed directly without a 7-day transition period, symptoms such as diarrhea, vomiting, and anorexia will not occur. DETAILED DESCRIPTION

[0011] Embodiments of the present invention are described in detail below, and the examples of the embodiments are intended to be used to explain the present invention, but should not be construed as limiting the present invention. In the embodiments, if specific techniques or conditions are not specified, they are carried out according to the techniques or conditions described in the literature in this area or according to the product specification. If the manufacturer is not specified for reagents or instruments used, they are all conventional products that can be obtained commercially.

[0012] Example 1: A method for preparing fullerene microcapsule powder

[0013] S1. Prepare a nutritional compound oil by mixing olive oil, linseed oil and Xanthoceras sorbifolia oil in a volume ratio of 5:3:2;

[0014] S2, 2.5g fullerene C 60 After sterilization, dissolve in 1L of nutritional compound oil to form a compound oil complex;

[0015] S3, dissolving 10g sodium caseinate, 5g dipotassium hydrogen phosphate, and 15g mono- and di-glycerol fatty acid esters into the composite oil compound to obtain an oil phase;

[0016] S4, dissolving 473 g of maltodextrin in 1 L of hot water (e.g., 80° C. hot water for easy dissolution) to obtain an aqueous phase;

[0017] S5, mixing the obtained water phase and oil phase, stirring evenly, and then sterilizing;

[0018] S6, homogenizing and spray drying to obtain fullerene microcapsule powder, wherein the content of fullerene in the fullerene microcapsule powder is 0.25wt%, and the particle size of the fullerene microcapsule powder is 20-500μm.

[0019] The fullerene microcapsule powders with fullerene contents of 0.4wt%, 0.5wt%, 0.6wt%, 0.7wt% and 0.8wt% can be prepared in the same manner.

[0020] Example 2: A method for preparing fullerene compound oil

[0021] Fullerene C 60 The mixture is dispersed in a nutritional compound oil prepared by olive oil, linseed oil and Xanthoceras sorbifolia oil in a volume ratio of 5:3:2 to obtain a mixed solution. The mixed solution is subjected to ball milling or ultrasound, and then centrifuged and filtered in sequence. The filtrate is collected to obtain a fullerene compound oil. The fullerene content in the fullerene compound oil is 0.5wt%.

[0022] Test Example 1: Fullerene microcapsule powder helps cats smoothly transition to a new diet

[0023] 1. Materials and Methods

[0024] 1.1 Experimental animals

[0025] This experiment selected healthy adult cats of similar weight and age (the breeds were: Ragdoll cats, British Shorthair cats, Chinchilla cats, and Chinese rural cats).

[0026] 1.2 Test methods

[0027] 30 healthy adult cats of similar weight (about 6-7 kg) and age (3-4 years old) were selected for a 7-day staple food replacement test. The test was divided into two treatment groups, namely a blank group and a fullerene group, with 15 replicates in each group. The blank group was fed with a mixed cat food of 20% cat food A and 80% cat food B by weight on the first and second days, and a mixed cat food of 50% cat food A and 50% cat food B from the third to the fifth day. On the sixth day, a mixed cat food of 80% cat food A and 20% cat food B was fed according to the weight ratio, and on the seventh day, cat food B was fed. The fullerene group was fed in the same way as above, but 0.2wt% of fullerene microcapsule powder (i.e., the fullerene microcapsule powder with a fullerene content of 0.25wt% prepared in Example 1) was added to the mixed cat food.

[0028] 1.2.2 Sample collection and determination

[0029] 1.2.2.1 Daily Management

[0030] During the experiment, the cats' mental state was observed every day, and the experimental records were kept. On the 7th day of the food change, the cats' fur color and mood were scored. The highest and lowest values ​​were removed from each group, and the average score was taken as the final score. A 5-point scoring system was used, and the higher the score, the better the performance. Score evaluation method: 5 points means that the spirit is very good, the fur color is smooth, and there is no difference from before the food change; 4 points means that the mental state is good, the fur color is smooth and there is slight hair loss; 3 points means that the spirit is slightly depressed, not active, the fur color is messy and there is slight hair loss; 2 points means that the spirit is depressed, the response to teasing is slow, the fur color is messy and there is a lot of hair loss; 1 point means that the spirit is depressed, the eyes are dull, the appetite is poor, the fur color is messy and gray, the hair loss is serious, and there is no obvious response to teasing.

[0031] 1.2.2.2 Observe the hardness of cat feces

[0032] During the test, the cats were observed for the number of times they defecate and the softness of their feces. The scores were scored on a scale of 1-5, with the lower the score, the softer the feces. Scoring criteria: 5 points means the feces are granular, dry and free of moisture; 4 points means the feces are strip-shaped, but segmented, dry and free of moisture; 3 points means the feces are a complete strip, dry and contain a small amount of moisture; 2 points means the feces are a complete strip, moist and relatively wet; 1 point means the feces are a complete strip, with a high moisture content and easy to break.

[0033] 1.2.3 Data Analysis

[0034] The data were analyzed by variance analysis using SPSS 25.0 and multiple comparisons were performed using the Turkey method.

[0035] 2. Test results and analysis

[0036] Table 1 Experimental results

[0037]

[0038]

[0039] From the experimental results we can see that:

[0040] Comparison of cat feces softness: The feces of the cats in the fullerene group were softer than those in the control group, and were softer than the control group every day.

[0041] Comparison of bowel movement frequency: cats in the fullerene group had fewer bowel movements, with fewer bowel movements per day than the control group.

[0042] Comparison of food intake: The cats in the fullerene group ate more food than those in the control group.

[0043] Weight comparison: The weight of the cats in the fullerene group barely changed before and after the experiment, while the weight of the cats in the control group became lighter after the experiment than before the experiment.

[0044] Comparison of cats' coat color and mood: Cats in the fullerene group had better coat color and mood than cats in the control group.

[0045] Comparison of vomiting frequency: The vomiting frequency of cats in the fullerene group was significantly lower than that of cats in the control group.

[0046] The above shows that fullerene can make it easy for cats to change their food, especially for problems such as diarrhea, vomiting, and anorexia. If the food is changed directly without a 7-day transition period, symptoms such as diarrhea, vomiting, and anorexia will not occur.

[0047] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations on the present invention. A person skilled in the art may change, modify, replace and modify the above embodiments within the scope of the present invention without departing from the principles and intent of the present invention.

Claims

1. Fullerene can improve the discomfort of cats during the food change period.

2. The use according to claim 1, characterized in that The improving the cat's discomfort period when changing food is to reduce the diarrhea, vomiting and anorexia of the cat when changing food.

3. The use according to claim 1, characterized in that The use is to use it as a feed additive to improve the discomfort period of cats during food change.

4. The use according to claim 1, characterized in that The fullerene is fullerene C60, C60 derivatives, and C60 water-soluble and oil-soluble mixtures.

5. A method for improving the discomfort period of cats when changing food, characterized in that: Feed a feed additive containing fullerenes.

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