Reagent storage device and reagent handling system

Abstract

A reagent storage device (1) and a reagent operation system. The reagent storage device (1) comprises a reagent bin (10), a reagent box storage unit (20) arranged in the reagent bin (10) and comprising a reagent box accommodating space (20A) configured to place a reagent box (30) having a reagent storage space (30A), and one or more piercing units (40) comprising a sample adding needle (41) having an internal passage (41A) and a piercing end (41C) provided with a sample adding needle needle hole (41B) in communication with the internal passage (41A), the piercing unit (40) being movably arranged relative to the reagent box storage unit (20) and having a first piercing working state and a second piercing working state, the piercing unit (40) being configured to, in a state of placing the reagent box (30) in the reagent box accommodating space (20A), in the first piercing working state, the sample adding needle needle hole (41B) being in communication with the reagent storage space (30A) of the reagent box (30), and in the second piercing working state, the sample adding needle needle hole (41B) being disconnected from the reagent storage space (30A) of the reagent box (30), the piercing end (41C) of the sample adding needle (41) of at least one piercing unit (40) being located outside or below the bottom of the corresponding reagent box accommodating space (20A).

Description

Technical Field

[0001] This invention relates to the field of fluid manipulation technology, and in particular to a reagent storage device and a reagent operating system. Background Technology

[0002] In some fluid manipulation devices, such as medical testing equipment like biochemical and gene sequencers, a series of physicochemical reactions are required to detect samples. These reactions necessitate the addition of different reagents. Each test requires the addition of multiple reagents, necessitating the design of a multi-channel switching valve and multiple pipelines to achieve the desired fluid flow path. Additionally, a complete sample dispensing mechanism needs to be designed.

[0003] like Figure 39 As shown, in related technologies, an external puncture sampling mechanism 40' is generally set outside the reagent compartment 10', and the external puncture sampling mechanism 40' is used to puncture and sample the reagents stored in the reagent compartment 10' from above. Summary of the Invention

[0004] This invention provides a reagent storage device and a reagent operating system.

[0005] The first aspect of this disclosure provides a reagent storage device, comprising:

[0006] The reagent compartment includes the internal storage space;

[0007] A reagent kit storage unit, disposed within the internal accommodating space, includes a reagent kit accommodating space configured to hold reagent kits with the reagent storage space; and

[0008] One or more puncture units, each puncture unit including a sample dispensing needle having an internal channel and a puncture tip, the puncture tip having a sample dispensing needle orifice communicating with the internal channel, the puncture unit being movably disposed relative to the reagent storage unit and having a first puncture working state and a second puncture working state, the puncture unit being configured such that: in the state where the reagent kit is placed in the reagent kit accommodating space, in the first puncture working state, the sample dispensing needle orifice is communicating with the reagent storage space of the reagent kit, and in the second puncture working state, the sample dispensing needle orifice is disconnected from the reagent storage space of the reagent kit, wherein the puncture tip of the sample dispensing needle of at least one of the puncture units is located on the outer side or below the bottom of the corresponding reagent kit accommodating space.

[0009] In some embodiments of the reagent storage device, the reagent storage device includes two or more puncture units disposed corresponding to the same reagent kit accommodating space.

[0010] In some embodiments of the reagent storage device, in two or more puncture units corresponding to the same reagent kit accommodating space, the puncture tip of the sample dispensing needle of at least one puncture unit is located on the top outer side or above the corresponding reagent kit accommodating space.

[0011] In some embodiments of the reagent storage device, the reagent storage unit includes a reagent protection portion disposed between the dispensing needle and the reagent accommodating space, the reagent protection portion having a puncture end avoidance opening for avoiding the puncture end of the dispensing needle.

[0012] In some embodiments of the reagent storage device, the sampling needle of at least a portion of the puncture unit includes:

[0013] The internal channel is located within the sample dispensing needle tube; and

[0014] The tip of the sampling needle is located at the puncture end of the sampling needle and is connected to one end of the sampling needle tube. The tip of the sampling needle is a cone with a cross-section that gradually decreases from the sampling needle tube to the side away from the sampling needle tube. The sampling needle hole is located on the side wall of the sampling needle tube near the tip of the sampling needle.

[0015] In some embodiments of the reagent storage device, the sampling needle includes a sampling needle tube and a sampling needle tip located at the puncture end and connected to the sampling needle tube, wherein,

[0016] The sampling needle tube has at least one bent section; and / or

[0017] The sample dispensing needle tube has at least one flexible tube segment; and / or

[0018] The sample dispensing needle tube has at least one telescopic section.

[0019] In some embodiments of the reagent storage device, the sample dispensing needle includes:

[0020] The first straight section of the dispensing needle extends along the surface of the reagent compartment wall; and

[0021] The second straight section of the dispensing needle extends from one side of the surface of the reagent compartment wall into the reagent kit accommodating space. One end of the second straight section of the dispensing needle is connected to one end of the first straight section of the dispensing needle through a bent section of the dispensing needle. The tip of the dispensing needle is connected to the other end of the second straight section of the dispensing needle.

[0022] In some embodiments of the reagent storage device, the puncture unit further includes a sample dispensing needle mounting portion, on which the sample dispensing needle is fixed.

[0023] In some embodiments of the reagent storage device, the reagent storage device further includes a puncture driving unit, including a switching part that is driven connected to or driven to cooperate with the puncture unit, the switching part being configured to drive the puncture unit to switch between a first puncture working state and a second puncture working state.

[0024] In some embodiments of the reagent storage device, the reagent storage device includes two or more puncture units, and the puncture driving unit includes two or more switching parts corresponding to the puncture units, wherein at least two of the switching parts are arranged in conjunction.

[0025] In some embodiments of the reagent storage device, the reagent storage device includes two or more puncture units corresponding to the same reagent kit accommodating space. The puncture driving unit includes two or more switching parts corresponding to the two or more puncture units in the same reagent kit accommodating space, and the two or more switching parts are linked together so that the corresponding two or more puncture units can be synchronously switched from the first puncture working state to the second puncture working state or from the second puncture working state to the first puncture working state.

[0026] In some embodiments of the reagent storage device, the puncture unit includes a sampling needle mounting part and a plurality of sampling needles, the plurality of sampling needles being mounted on the sampling needle mounting part, and the switching part being driven connected or driven to cooperate with the sampling needle mounting part of the puncture unit to drive the plurality of sampling needles to move synchronously.

[0027] In some embodiments of the reagent storage device, the switching unit includes a dispensing needle drive mechanism configured to apply a force to the puncture unit to switch it from a first puncture working state to a second puncture working state and / or apply a force to switch it from the second puncture working state to the first puncture working state.

[0028] In some embodiments of the reagent storage device, the dispensing needle drive mechanism includes:

[0029] The first active part has a first drive working position and a second drive working position;

[0030] The second movable part is driven to connect or cooperate with the first movable part and the puncture unit to transmit the action of the first movable part to the puncture unit. When the first movable part is in the first driven working position, the puncture unit is in one of the first puncture working state and the second puncture working state. When the first movable part is in the second driven working position, the puncture unit is in the other of the first puncture working state and the second puncture working state.

[0031] In some embodiments of the reagent storage device, the puncture drive unit includes a linkage part, which is driven to be connected to or driven to cooperate with at least two switching parts so that the puncture units corresponding to the at least two switching parts move synchronously.

[0032] In some embodiments of the reagent storage device, the puncture drive unit includes:

[0033] A limiting portion, the limiting portion being configured to limit the range of motion of the first movable portion and / or the second movable portion; and / or

[0034] A guide portion, which is configured to guide the movement of the first movable portion and / or the second movable portion.

[0035] In some embodiments of the reagent storage device,

[0036] The limiting portion is configured to limit the range of motion of the linkage portion to limit the range of motion of the first movable portion and / or the second movable portion; and / or

[0037] The guide portion is configured to guide the movement of the linkage portion in order to guide the movement of the first movable portion and / or the second movable portion.

[0038] In some embodiments of the reagent storage device,

[0039] The limiting portion includes one or more limiting structures, at least one of the limiting structures including a limiting groove and a limiting surface, the limiting surface being movably located within the limiting groove and having an abutment state with the limiting groove, one of the limiting groove and the limiting surface being fixed relative to one of the first movable portion and the second movable portion, and the other being fixed relative to the other of the first movable portion and the second movable portion; and / or

[0040] The guide portion includes one or more guide structures, at least one guide structure includes a guide groove and a guide surface, the guide surface slides in conjunction with the guide groove, one of the guide groove and the guide surface is fixed relative to the reagent compartment, and the other is fixed relative to the first movable portion or the second movable portion.

[0041] In some embodiments of the reagent storage device, the puncture drive unit further includes a positioning part, which has a positioning state for maintaining the puncture unit in the first puncture working state and / or the second puncture working state and an avoidance state for preventing interference with the switching of the puncture unit's working position. The positioning part is movably disposed relative to the reagent compartment to switch between the avoidance state and the positioning state.

[0042] In some embodiments of the reagent storage device, the positioning unit cooperates with the reagent kit drive to switch between the avoidance state and the positioning state under the drive of the reagent kit.

[0043] In some embodiments of the reagent storage device, the positioning part includes a slider and a slider reset mechanism. The slider is movably mounted relative to the reagent compartment within the internal accommodating space and includes a positioning surface. The slider is driven to cooperate with the reagent kit. In the avoidance state of the positioning part, the slider is in an avoidance position where the positioning surface is separated from the second movable part, and the slider reset mechanism is in a charging state. In the positioning state of the positioning part, the slider is in a positioning position where the positioning surface abuts against the second movable part, and the slider reset mechanism is in a releasing state.

[0044] In some embodiments of the reagent storage device,

[0045] The first movable part includes a first translation component, which is reciprocally movable relative to the reagent chamber along a first direction. The first translation component is provided with a driving surface, which is inclined along the first direction toward a second direction perpendicular to the first direction.

[0046] The second movable part includes a second translation component, which is fixedly disposed relative to the sample dispensing needle and reciprocally movable relative to the reagent chamber along the second direction. The second translation component has a mating surface corresponding to the driving surface. The mating surface is inclined towards the second direction along the first direction. By changing the position of the first translation component in the first direction, the mating position of the driving surface and the mating surface is changed, thereby changing the position of the second translation component along the second direction.

[0047] In some embodiments of the reagent storage device, the puncture drive unit includes a linkage part, which is driven to connect with or cooperate with at least two switching parts to synchronize the movement of the puncture units corresponding to the at least two switching parts.

[0048] The linkage includes a push-pull rod extending along the first direction;

[0049] The first translation component is fixed to the push-pull rod, and the driving surface is disposed on the side of the push-pull rod near the second translation component;

[0050] The second translation component includes a pressure plate arranged along the second direction, and the mating surface is disposed at the end of the pressure plate near the first translation component.

[0051] In some embodiments of the reagent storage device,

[0052] The puncture drive unit includes a limiting part configured to limit the range of motion of the linkage part to limit the range of motion of the first movable part. The limiting part includes one or more limiting structures, at least one of which includes a limiting groove and a limiting surface. The limiting surface is movably located within the limiting groove and has an abutment with the limiting groove. One of the limiting groove and the limiting surface is disposed on the second movable part, and the other is disposed on the push-pull rod; and / or

[0053] The puncture drive unit includes a guide portion configured to guide the movement of the linkage portion to guide the movement of the first movable portion. The guide portion includes one or more guide structures, at least one of which includes a guide groove and a guide surface. One of the guide groove and the guide surface is fixed relative to the reagent chamber, and the other is disposed on the push-pull rod.

[0054] In some embodiments of the reagent storage device,

[0055] The first movable part includes a first rotating component, which is rotatably disposed relative to the reagent chamber;

[0056] The second movable part includes a second rotating component, which is rotatably disposed relative to the reagent chamber and is drivenly connected to or driven to cooperate with the first rotating component. The second rotating component drives the puncture unit to switch between the first puncture working state and the second puncture working state.

[0057] In some embodiments of the reagent storage device,

[0058] The first rotating component is a rotating shaft;

[0059] The second rotating component includes a cam disposed on the rotating shaft, the cam engaging with the puncture unit.

[0060] In some embodiments of the reagent storage device, the puncture drive unit further includes a movable connection portion connected to the cam and the puncture unit respectively, configured to transmit the motion of the cam to the puncture unit so that the rotation of the cam drives the puncture unit to move.

[0061] In some embodiments of the reagent storage device, the movable connection includes:

[0062] The first pin is disposed on the end face of the cam;

[0063] The second pin is disposed on the puncture unit at a distance parallel to the first pin;

[0064] A movable element having an arc-shaped groove is mounted on the cam and the puncture unit via a first pin and a second pin that engage with the arc-shaped groove, with the first pin and the second pin slidingly engaging with the arc-shaped groove.

[0065] In some embodiments of the reagent storage device,

[0066] The puncture drive unit includes a linkage part, which is driven to be connected or driven to cooperate with at least two switching parts to make the puncture units corresponding to the at least two switching parts move synchronously.

[0067] The linkage includes at least one of a belt drive mechanism, chain drive mechanism, gear drive mechanism, gear and rack drive mechanism, or linkage mechanism connected between the first rotating components of the at least two switching parts.

[0068] In some embodiments of the reagent storage device, the puncture drive unit further includes an actuator, which is driven connected to or driven to cooperate with the first movable part; the actuator includes:

[0069] A handle or rotary lever is driven to connect or engage with the first movable part; or

[0070] An actuator is driven to connect to or cooperate with the first moving part.

[0071] In some embodiments of the reagent storage device, the switching unit includes a sample dispensing needle reset mechanism, wherein,

[0072] One of the sampling needle drive mechanism and the sampling needle reset mechanism is configured to apply a force to the puncture unit to switch it from the first puncture working state to the second puncture working state;

[0073] The other of the sampling needle drive mechanism and the sampling needle reset mechanism is configured to apply a force to the puncture unit to switch it from the second puncture working state to the first puncture working state.

[0074] In some embodiments of the reagent storage device, the sample dispensing needle reset mechanism includes at least one spring; wherein,

[0075] The spring is located and / or connected between the puncture unit and the reagent storage unit; or

[0076] The spring is located and / or connected between the puncture unit and the reagent chamber.

[0077] In some embodiments of the reagent storage device, the reagent storage device includes a plurality of said reagent kit storage units, and / or, said reagent kit storage units include a plurality of said reagent kit accommodating spaces.

[0078] In some embodiments of the reagent storage device, the reagent storage device further includes a heat preservation unit configured to maintain the temperature of the reagent compartment.

[0079] In some embodiments of the reagent storage device, the insulation unit includes a refrigerant circulation system configured to regulate the temperature inside the reagent chamber.

[0080] In some embodiments of the reagent storage device,

[0081] The reagent storage device includes a reagent kit, the reagent kit includes a reagent storage space, and the reagent kit accommodating space of the reagent storage device is used to place the reagent kit.

[0082] In the first puncture working state of the puncture unit, the needle hole of the sample dispensing needle is connected to the reagent storage space of the reagent kit placed in the reagent kit accommodating space. In the second puncture working state of the puncture unit, the needle hole of the sample dispensing needle is disconnected from the reagent storage space of the reagent kit placed in the reagent kit accommodating space.

[0083] In some embodiments of the reagent storage device, the reagent kit has a weak portion corresponding to the puncture end of the dispensing needle. In the first puncture working state of the puncture unit, the puncture end of the dispensing needle enters the reagent storage space by puncturing the weak portion, thereby enabling the dispensing needle hole of the dispensing needle to communicate with the reagent storage space of the reagent kit.

[0084] In some embodiments of the reagent storage device, at least one of the puncture units is located within the internal containment space.

[0085] In some embodiments of the reagent storage device, a base plate is also included, which is located within the internal accommodating space and mounted on the bottom wall of the reagent compartment, and the reagent kit storage unit and / or the puncture unit is mounted on the base plate.

[0086] A second aspect of this disclosure provides a reagent operating system, including the reagent storage device described in the first aspect of this disclosure; wherein the reagent operating system further includes:

[0087] The reagent receiving part is in communication with the internal channel of the sample dispensing needle of at least one of the puncture units; and / or

[0088] The cleaning fluid delivery unit is in communication with the internal channel of the sampling needle of at least one of the puncture units; and / or

[0089] The gas communication section is in communication with the internal channel of the sampling needle of at least one of the puncture units.

[0090] In some embodiments of the reagent operating system,

[0091] The reagent operating system includes a reagent receiving unit and a cleaning solution delivery unit, wherein the reagent receiving unit and the cleaning solution delivery unit are respectively connected to the internal channels of the sample dispensing needles of different puncture units; and / or

[0092] The reagent operating system includes the cleaning solution delivery unit and the gas communication unit, which are connected to the internal channel of the sample application needle of the same puncture unit at different times.

[0093] In some embodiments of the reagent operating system, the reagent operating system includes the reagent receiving unit and the cleaning solution delivery unit, wherein,

[0094] The puncture end of the sample dispensing needle of the puncture unit, which is in communication with the reagent receiving part, is located on the bottom outside or below the corresponding reagent kit accommodating space;

[0095] The puncture end of the sample dispensing needle of the puncture unit, which is in communication with the cleaning solution delivery unit, is located on the top outer side or above the corresponding reagent kit accommodating space.

[0096] In some embodiments of the reagent operating system,

[0097] The reagent receiving part is connected to the sample dispensing needle of at least one of the puncture units via a connecting tube having a flexible section or a telescopic section; and / or

[0098] The cleaning fluid delivery unit is connected to the sampling needle of at least one of the puncture units via a connecting tube having a flexible section or a telescopic section; and / or

[0099] The gas communication section is connected to the sampling needle of at least one of the puncture units via a connecting tube having a flexible section or a telescopic section.

[0100] In some embodiments of the reagent operating system,

[0101] The reagent receiving unit is connected to the sampling needle of at least one of the puncture units via a connecting tube that passes through the chamber and is sealed between the chamber and the chamber; and / or

[0102] The cleaning fluid delivery unit is connected to the sampling needle of at least one of the puncture units via a connecting tube that passes through the chamber and is sealed between the chamber and the chamber; and / or

[0103] The gas communication section is connected to the sampling needle of at least one of the puncture units via a connecting tube that passes through the chamber and is sealed between the chamber and the chamber.

[0104] The reagent storage device provided in this disclosure allows for the connection and disconnection of the needle hole at the puncture end of the puncture unit with the reagent storage space of the corresponding reagent kit by a small movement of the puncture unit when the puncture end is located at the bottom outside or below the corresponding reagent kit accommodating space. It also enables the reagent in the reagent storage space to be emptied, which helps to save the space occupied by the reagent storage device.

[0105] The reagent operating system disclosed herein has the same advantages as the reagent storage device disclosed herein. Attached Figure Description

[0106] The accompanying drawings, which are included to provide a further understanding of the invention and form part of this disclosure, illustrate exemplary embodiments of the invention and, together with their description, serve to explain the invention and do not constitute an undue limitation thereof. In the drawings:

[0107] Figure 1 This is a schematic diagram of the structure of a reagent storage device according to an embodiment of the present disclosure.

[0108] Figure 2 for Figure 1 A schematic diagram of the reagent storage device from another direction.

[0109] Figure 3 for Figure 1 The diagram shows the structure of a reagent storage device, with one reagent kit located outside the reagent kit containing space.

[0110] Figure 4 for Figure 1 The schematic diagram of the reagent storage device shown has removed the reagent compartment, with one of the reagent kits located outside the reagent compartment.

[0111] Figure 5 for Figure 1 The diagram shown is a structural schematic of the reagent storage device without the reagent compartment.

[0112] Figure 6 for Figure 1 The diagram shows a reagent storage device with the reagent compartment removed from another direction, where one of the reagent kits is located outside the reagent housing space.

[0113] Figure 7 for Figure 1 The schematic diagram of the reagent storage device shown has the reagent compartment removed from its top view.

[0114] Figure 8 for Figure 1 The schematic diagram of the reagent storage device shown has the reagent compartment removed.

[0115] Figure 9 for Figure 1 The diagram shows a reagent storage device from another direction, with the reagent compartment and base removed, and one of the reagent kits located outside the reagent housing space.

[0116] Figure 10 for Figure 1 The diagram shows a combined structure of the reagent storage unit, reagent kit, puncture unit, and puncture drive unit of the reagent storage device, wherein the puncture unit is in the second puncture working state.

[0117] Figure 11 for Figure 10 A magnified schematic diagram of a part of the structure.

[0118] Figure 12 for Figure 1 A schematic diagram of the positioning part of the puncture drive unit of the reagent storage device shown.

[0119] Figure 13 for Figure 10 A magnified schematic diagram of another part of the structure.

[0120] Figure 14 for Figure 1 The diagram shows a combined structure of the reagent storage unit, reagent kit, puncture unit, and puncture drive unit of the reagent storage device, wherein the puncture unit is in the first puncture working state.

[0121] Figure 15 for Figure 14 A schematic diagram of a local structure of one part.

[0122] Figure 16 for Figure 14 A magnified schematic diagram of another part of the structure.

[0123] Figure 17 for Figure 1 A schematic diagram of the sample dispensing needle in the puncture unit of the reagent storage device shown.

[0124] Figure 18 for Figure 11 A schematic diagram of the cross-sectional structure of the sample dispensing needle from another direction.

[0125] Figure 19 for Figure 1 The diagram shows an exploded view of the reagent storage device.

[0126] Figure 20This is a schematic diagram of the structure of a reagent storage device according to another embodiment of the present disclosure.

[0127] Figure 21 for Figure 20 A schematic diagram of the reagent storage device from another direction.

[0128] Figure 22 for Figure 20 The diagram shows the structure of a reagent storage device, with one reagent kit located outside the reagent kit containing space.

[0129] Figure 23 for Figure 20 The diagram shown is a structural schematic of the reagent storage device without the reagent compartment.

[0130] Figure 24 for Figure 20 The diagram shown is a structural schematic of a reagent storage device without the reagent compartment and insulation unit.

[0131] Figure 25 for Figure 20 A schematic diagram of the reagent storage device from another direction.

[0132] Figure 26 for Figure 20 The schematic diagram of the reagent storage device shown has removed the reagent compartment, with one of the reagent kits located outside the reagent compartment.

[0133] Figure 27 for Figure 20 The diagram shows a reagent storage device with the reagent compartment removed from another direction.

[0134] Figure 28 for Figure 20 The diagram shows a reagent storage device with the reagent compartment removed from another direction.

[0135] Figure 29 for Figure 20 The diagram shown is a disassembled structural representation of the reagent storage device without the reagent compartment.

[0136] Figure 30 for Figure 29 A partially enlarged structural diagram.

[0137] Figure 31 for Figure 20 The diagram shows a top view of the reagent storage device.

[0138] Figure 32 for Figure 31 A schematic diagram of the AA-direction cross-section structure.

[0139] Figure 33 for Figure 20The schematic diagram of the reagent storage device shown has the reagent compartment removed from its top view.

[0140] Figure 34 for Figure 33 A schematic diagram of the three-dimensional structure in BB direction.

[0141] Figure 35 for Figure 20 The diagram shows a partial structural representation of the reagent storage device, including the puncture unit, the puncture drive unit, and the reagent kit.

[0142] Figure 36 for Figure 20 The diagram shows a partial structural representation of the reagent storage device, including the puncture unit and the puncture drive unit.

[0143] Figure 37 for Figure 36 The diagram shows a partial exploded structure.

[0144] Figure 38 This is a schematic diagram illustrating the principle of a reagent operating system according to an embodiment of the present disclosure.

[0145] Figure 39 This is a schematic diagram of the structure of the reagent operating system for related technologies. Detailed Implementation

[0146] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the present invention or its application or use. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0147] Unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps set forth in these embodiments do not limit the scope of the invention. It should also be understood that, for ease of description, the dimensions of the various parts shown in the drawings are not drawn to actual scale. Techniques, methods, and devices known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and devices should be considered part of the specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters in the following figures denote similar items; therefore, once an item is defined in one figure, it need not be further discussed in subsequent figures.

[0148] In the process of realizing this disclosure, the inventors discovered the following phenomena in the related technology:

[0149] When the external sample dispensing mechanism 40' is used, the total volume of the sample dispensing mechanism 40' and the reagent chamber 10' is too large.

[0150] The external sample dispensing mechanism 40' outside the reagent compartment 10' cannot be well isolated from the air, resulting in a large amount of condensation. Specifically, the reagent compartment 10' has a refrigeration function, and its top has multiple through holes through which the sample dispensing needle 41' passes. Outside air can easily enter the reagent compartment 10' through these through holes, forming condensation, which then carries dust and impurities into the reagent kit and contaminates the reagents.

[0151] It is difficult to achieve automatic cleaning of the sample dispensing mechanism 40' and sample dispensing needle 41', or it is very difficult to clean them automatically.

[0152] To address the aforementioned problems, this disclosure provides a reagent storage device 1 and a reagent operating system.

[0153] like Figures 1 to 37 As shown, the reagent storage device 1 of this embodiment includes a reagent compartment 10, a reagent kit storage unit 20, and one or more puncture units 40. The reagent compartment 10 includes an internal accommodating space. The reagent kit storage unit 20 is disposed within the internal accommodating space and includes a reagent kit accommodating space 20A, which is configured to hold a reagent kit 30 having a reagent storage space 30A. The puncture unit 40 includes a sampling needle 41. The sampling needle 41 has an internal channel 41A and a puncture end 41C, and the puncture end 41C has a sampling needle hole 41B communicating with the internal channel 41A. The puncture unit 40 is movably disposed relative to the reagent kit storage unit 20 and has a first puncture working state and a second puncture working state. The puncture unit 40 is configured such that, with the reagent kit 30 placed in the reagent kit accommodating space 20A, in the first puncture working state, the needle hole 41B of the dispensing needle is connected to the reagent storage space 30A of the reagent kit 30, and in the second puncture working state, the needle hole 41B of the dispensing needle is disconnected from the reagent storage space 30A of the reagent kit 30, wherein the puncture end 41C of the dispensing needle 41 of at least one puncture unit 40 is located on the bottom outside or below the corresponding reagent kit accommodating space 20A.

[0154] When the puncture end 41C of the sampling needle 41 of the puncture unit 40 is located at the bottom outer side or below the corresponding reagent storage space 20A, a slight movement of the puncture unit 40 can achieve the connection and disconnection between the sampling needle hole 41B of the puncture end 41C and the reagent storage space 30A of the reagent kit 30, and can also empty the reagent in the reagent storage space 30A, which helps to save the space occupied by the reagent storage device 1. This solves the problem of the excessively large total volume of the sampling mechanism 40' and the reagent compartment 10' in related technologies.

[0155] like Figures 1 to 37 In the illustrated embodiment, the reagent compartment 10 includes, for example, a compartment body 11 and a compartment door 12 for closing the compartment body 11. The compartment body 11 and the compartment door 12 together form the internal receiving space of the reagent compartment 10. The compartment body 11 is, for example, a cube with its opening facing one side. In embodiments not shown, the compartment body 11 may be configured in other shapes, such as cylindrical.

[0156] like Figures 1 to 37 In the embodiments shown, in some embodiments of the reagent storage device 1, the compartment door 12 is hinged to the compartment body 11. The opening of the compartment body 11 faces the side of the compartment body 11, and the compartment door 12 is hinged to one side of the compartment body 11. In embodiments not shown, the compartment body 11 may be hinged to the top surface of the compartment body 11 with the compartment door 12, or the compartment body 11 and the compartment door 12 may be detachably connected by a snap-fit ​​or other means to enable the compartment body 11 to be opened and closed.

[0157] In some other embodiments not shown, the reagent compartment 10 can be directly configured as a closed compartment without a door.

[0158] The reagent kit 30 may include only one reagent storage space 30A, or it may include multiple reagent storage spaces 30A, for example, in Figures 1 to 37 In the illustrated embodiment, there are multiple reagent storage spaces 30A. When the reagent kit 30 has multiple reagent storage spaces 30A, the reagent kit 30 may have only a single reagent kit housing 31, with the multiple reagent storage spaces separated by partition walls within the single reagent kit housing 31. When the reagent kit 30 has multiple reagent storage spaces 30A, the reagent kit 30 may also include multiple reagent kit housings 31. Each reagent kit housing 31 may include only a single reagent storage space, or some reagent kit housings 31 may include a single reagent storage space while others include multiple reagent storage spaces, or all reagent kit housings 31 may include multiple reagent storage spaces.

[0159] like Figures 1 to 37In the embodiments shown, in some embodiments of the reagent storage device 1, the reagent storage device 1 includes or is used in conjunction with the reagent storage device 1, and the reagent kit 30 includes a plurality of reagent kit boxes 31, each reagent kit box 31 having a single reagent storage space 30A.

[0160] In the embodiments of this disclosure, "multiple" refers to two or more, such as two, three, five, eight, thirteen, etc.

[0161] In some embodiments of the reagent storage device 1, the reagent storage device 1 includes two or more puncture units 40 corresponding to the same reagent kit accommodating space 20A. For example, such as Figures 1 to 37 In the embodiment shown, two puncture units 40 are provided corresponding to the same reagent kit accommodating space 20A.

[0162] The reagent storage device 1 includes two or more puncture units 40 corresponding to the same reagent kit accommodating space 20A. The sampling needles 41 of different puncture units 40 can be connected to the required functional modules, such as reagent receiving unit, cleaning solution delivery unit or gas communication unit, according to different needs, so as to realize different functions such as sampling, improving the working efficiency of sampling needle 41 or cleaning sampling needle 41.

[0163] In some embodiments of the reagent storage device 1, among two or more puncture units 40 corresponding to the same reagent kit accommodating space 20A, the puncture end 41C of the sample dispensing needle 41 of at least one puncture unit 40 is located on the bottom outer side or below the corresponding reagent kit accommodating space 20A; and / or among two or more puncture units 40 corresponding to the same reagent kit accommodating space 20A, the puncture end 41C of the sample dispensing needle 41 of at least one puncture unit 40 is located on the top outer side or above the corresponding reagent kit accommodating space 20A.

[0164] When the puncture tip 41C of the sampling needle 41 of the puncture unit 40 is located on the top outer side or above the corresponding reagent storage space 20A, a small movement of the puncture unit 40 can connect or disconnect the sampling needle hole 41B of the puncture tip 41C from the reagent storage space 30A of the reagent kit 30, and can also inject reagents, cleaning solutions, or gases into the reagent storage space 30A. Since the corresponding puncture unit 40 only needs a small movement, there is no need to reserve a large space for the puncture unit, which is conducive to the miniaturization of the reagent storage device.

[0165] like Figures 1 to 37In the illustrated embodiment, two puncture units 40 are provided corresponding to each reagent kit accommodating space 20A, one above the other. The puncture tip 41C of the sampling needle 41 of the lower puncture unit 40 is located below the corresponding reagent kit accommodating space 20A. The lower puncture unit 40 is used to extract reagents from the reagent kit 30. The puncture tip 41C of the sampling needle 41 of the upper puncture unit 40 is located above the corresponding reagent kit accommodating space 20A. The upper puncture unit 40 can be used to communicate with gas to facilitate reagent extraction when the lower puncture unit 40 extracts reagents from the reagent kit 30, and can also be used to introduce cleaning solution into the reagent storage space 30A after the lower puncture unit 40 has extracted reagents from the reagent kit 30, to clean the sampling needle 41 of the lower puncture unit 40.

[0166] In some embodiments of the reagent storage device 1, the reagent storage unit 20 includes a reagent protection part 21 disposed between the sample dispensing needle 41 and the reagent accommodating space 20A, and the reagent protection part 21 has a puncture end avoidance port 21A for avoiding the puncture end 41C of the sample dispensing needle 41.

[0167] The reagent kit protective section 21 is provided to easily protect the reagent kit 30, preventing the reagent kit 30 from touching the sample dispensing needle 41 during the process of entering the reagent kit containing space 20A. It also facilitates the accurate positioning of the reagent kit 30 inside the reagent kit storage unit 20. Thus, when the puncture unit 40 switches its working position, the sample dispensing needle hole 41B of the sample dispensing needle 41 can be accurately connected or disconnected from the corresponding reagent storage space 30A according to the working position of the puncture unit 40.

[0168] The reagent kit protective section 21 is, for example, a reagent kit protective plate. Figures 1 to 37 In the illustrated embodiment, each reagent kit storage unit 20 includes two parallel, spaced-apart square reagent kit protective plates. A connecting rod 22 is provided at each of the four corners of the two protective plates, and each connecting rod 22 is fixedly connected to the two protective plates. Each connecting rod 22 passes through both protective plates. The upper and lower ends of the connecting rod 22 are located above and below the two protective plates, respectively. In embodiments not shown, the reagent kit protection part 21 can also be a perforated plate, a frame, a track, or other forms.

[0169] In some embodiments of the reagent storage device 1, such as Figure 17 and Figure 18As shown, at least part of the puncture unit 40 includes a sampling needle 41 comprising a sampling needle tube 411 and a sampling needle tip 412. An internal channel 41A is located within the sampling needle tube 411. The sampling needle tip 412 is located at the puncture end 41C of the sampling needle 41, connected to one end of the sampling needle tube 411. The sampling needle tip 412 is a cone whose cross-section gradually decreases from the sampling needle tube 411 towards the side away from the sampling needle tube 411. The sampling needle orifice 41B is located on the side wall of the sampling needle tube 411 near the sampling needle tip 412.

[0170] The structure of the sampling needle 41 allows the sampling needle hole 41B of the sampling needle 41 to be designed closer to the wall surface or adjacent wall surface into which the sampling needle 41 pierces the reagent storage space 30A. Thus, when the sampling needle 41 is located on the bottom outer side or below the reagent storage space 30A, it facilitates the complete outflow of reagents in the reagent storage space 30A. When the sampling needle 41 is located on the top outer side or above the reagent storage space 30A, it facilitates the entry of gases or cleaning agents into the reagent storage space 30A.

[0171] In some embodiments of the reagent storage device 1, such as Figure 4-10 , Figure 14 , Figure 17-18 , Figure 23-24 , Figure 26-29 , Figure 32-37 As shown, the sampling needle 41 includes a sampling needle tube 411 and a sampling needle tip 412 located at the puncture end 41C and connected to the sampling needle tube 411; wherein, the sampling needle tube 411 has at least one sampling needle bending section 4112; and / or the sampling needle tube 411 has at least one flexible section; and / or the sampling needle tube 411 has at least one telescopic section.

[0172] The sample dispensing needle tube 411 is provided with at least one bent section 4112, which is conducive to reasonably setting the shape of the sample dispensing needle 41 according to the surrounding environment of the sample dispensing needle 41, saving the space occupied by the sample dispensing needle 41 and its required movement space, and reducing the volume and cost of the reagent storage device 1.

[0173] The sample application needle tube 411 has at least one flexible tube section and / or the sample application needle tube 411 has at least one telescopic tube section, which helps to prevent the structure of the sample application needle 41 from being damaged or the part connected to the sample application needle from being affected when the puncture unit 40 switches working states.

[0174] In some embodiments of the reagent storage device 1, such as Figure 17-18As shown, the sample dispensing needle tube 411 includes a first straight sample dispensing needle section 4111, a bent sample dispensing needle section 4112, and a second straight sample dispensing needle section 4113. The first straight sample dispensing needle section 4111 extends along the surface of the reagent compartment 10. The second straight sample dispensing needle section 4113 extends from one side of the surface of the reagent compartment 10 toward the reagent kit containing space 20A. One end of the second straight sample dispensing needle section 4113 is connected to one end of the first straight sample dispensing needle section 4111 via a bent sample dispensing needle section 4112, and the sample dispensing needle tip 412 is connected to the other end of the second straight sample dispensing needle section 4113.

[0175] The above setup helps to save space occupied by the sample needle 41 and its movement space with the fewest possible bends in the tube.

[0176] In some embodiments of the reagent storage device 1, such as Figure 4-10 , Figure 14 , Figure 17-18 , Figure 23-24 , Figure 26-29 , Figure 32-37 As shown, the puncture unit 40 also includes a sampling needle mounting part 42, and the sampling needle 41 is fixed on the sampling needle mounting part 42.

[0177] The sample needle mounting part 42 can be, for example, a mounting plate, a mesh plate, a mounting frame, a mounting rod, etc. Figures 1 to 37 In the illustrated embodiment, the sample needle mounting portion 42 is a mounting plate. The sample needle 41 is mounted on the sample needle mounting portion 42 via its fixed connection portion 413.

[0178] The sampling needle mounting part 42 is provided to facilitate the accurate positioning of the sampling needle 41 and to enable the puncture unit 40 to switch between the first puncture working state and the second puncture working state by driving the sampling needle mounting part 42. This also helps to accurately control the working position of the sampling needle 41 and reduce damage to the sampling needle 41.

[0179] In some embodiments of the reagent storage device 1, such as Figure 1 , Figure 3-16 , Figure 20 , Figure 22-30 , Figure 32-37 As shown, the reagent storage device 1 also includes a puncture drive unit 50. The puncture drive unit 50 includes a switching part 51, which is driven connected to or driven to cooperate with the puncture unit 40 and is configured to drive the puncture unit 40 to switch between a first puncture working state and a second puncture working state.

[0180] The switching unit 51 facilitates the switching of the driving puncture unit 40 between the first puncture working state and the second puncture working state.

[0181] In some embodiments of the reagent storage device 1, such as Figure 1 , Figure 3-16 , Figure 20 , Figure 22-30 , Figure 32-37 As shown, the reagent storage device 1 includes two or more puncture units 40. When the reagent storage device 1 includes two or more puncture units 40, the reagent storage device 1 includes two or more switching parts 51, and the two or more switching parts 51 are driven connected or driven to cooperate with the two or more puncture units 40 in a one-to-one correspondence.

[0182] This configuration facilitates the control of the actions of each puncture unit 40 through the switching unit 51, so as to accurately and / or quickly achieve the actions required by each puncture unit 40.

[0183] In some embodiments of the reagent storage device 1, such as Figure 1 , Figure 3-16 , Figure 20 , Figure 22-30 , Figure 32-37 As shown, the reagent storage device 1 includes two or more puncture units 40, and the puncture drive unit 50 includes two or more switching parts 51 corresponding to the puncture units 40, wherein at least two switching parts 51 are arranged in conjunction.

[0184] At least two switching units 51 are linked together, which makes it easier to achieve the required action switching of the puncture unit 40 with fewer operation steps.

[0185] like Figures 1 to 37 In the illustrated embodiment, the reagent storage device 1 includes four puncture units 40 and two reagent kit accommodating spaces 20A. One puncture unit 40 is arranged on each of the upper and lower sides of each reagent kit accommodating space 20A. The reagent storage device 1 includes four switching units 51. Each reagent kit accommodating space 20A is correspondingly provided with two puncture units 40 and two switching units 51. The two switching units 51 corresponding to the same reagent kit accommodating space 20A are linked to simultaneously drive the two puncture units 40 corresponding to the same reagent kit accommodating space 20A.

[0186] In some embodiments of the reagent storage device 1, the reagent storage device 1 includes two or more puncture units 40 corresponding to the same reagent kit accommodating space 20A. The puncture driving unit 50 includes two or more switching parts 51 corresponding to the two or more puncture units 40 corresponding to the same reagent kit accommodating space 20A, and the two or more switching parts 51 are linked together so that the corresponding two or more puncture units 40 can be synchronously switched from a first puncture working state to a second puncture working state or from a second puncture working state to a first puncture working state.

[0187] Two or more switching units 51 corresponding to two or more puncture units 40 arranged in conjunction with each other in the same reagent kit accommodating space 20A are arranged so that the two or more corresponding puncture units 40 can be synchronously switched from the first puncture working state to the second puncture working state or from the second puncture working state to the first puncture working state. This facilitates the synchronous switching of working positions of the puncture units 40 corresponding to the same reagent kit accommodating space 20A, thereby simplifying the operation steps and ensuring accurate correspondence of working positions of different puncture units 40, which helps to reduce operational errors.

[0188] Figures 1 to 37 In the illustrated embodiment, the two puncture units 40 corresponding to the same reagent kit accommodating space 20A synchronously switch from the first puncture working state to the second puncture working state, and synchronously switch from the second puncture working state to the first puncture working state, under the linkage of the corresponding two switching parts 51.

[0189] In some embodiments of the reagent storage device 1, such as Figure 1 , Figure 3-16 , Figure 20 , Figure 22-30 , Figure 32-37 As shown, the puncture unit 40 includes a sampling needle mounting part 42 and a plurality of sampling needles 41. The plurality of sampling needles 41 are mounted on the sampling needle mounting part 42. The switching part 51 is driven to be connected to or driven to cooperate with the sampling needle mounting part 42 of the puncture unit 40 to drive the plurality of sampling needles 41 to move synchronously.

[0190] This configuration facilitates the synchronous movement of multiple sampling needles 41 driven by the switching unit 51, which improves the switching efficiency of the working position of the puncture unit 40 and enables each sampling needle 41 to synchronously connect or disconnect with the corresponding reagent storage space 30A.

[0191] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 8-10 , Figure 14 , Figure 23-24 , Figure 26-29 , Figure 32 , Figure 34-37 As shown, the switching unit 51 includes a sampling needle drive mechanism 511. The sampling needle drive mechanism 511 is configured to apply a force to the puncture unit 40 to switch it from a first puncture working state to a second puncture working state and / or apply a force to switch it from a second puncture working state to a first puncture working state.

[0192] like Figures 1 to 37 In the embodiment shown, the sample dispensing needle drive mechanism 511 is configured to apply a force to the puncture unit 40 to switch it from a first puncture working state to a second puncture working state.

[0193] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 8-11 , Figures 13-16 , Figure 23-24 , Figure 26-30 , Figure 32-37 As shown, the sample dispensing needle driving mechanism 511 includes a first movable part 5111 and a second movable part 5112. The first movable part 5111 has a first driving working position and a second driving working position. The second movable part 5112 is driven connected or driven to cooperate with the first movable part 5111 and the puncture unit 40. When the first movable part 5111 is in its first driving working position, the puncture unit 40 is in one of its first puncture working state and its second puncture working state. When the first movable part 5111 is in its second driving working position, the puncture unit 40 is in the other of its first puncture working state and its second puncture working state.

[0194] The sample dispensing needle drive mechanism 511 includes a first movable part 5111 and a second movable part 5112, which facilitates flexible configuration of the sample dispensing needle drive mechanism 511. For example, the direction and magnitude of the force at the input end and the force at the output end of the switching part 51 can be changed by configuring the first movable part 5111 and the second movable part 5112, which facilitates the linkage between different switching parts 51 and the limiting, guiding, and positioning functions of the switching part 51.

[0195] exist Figures 1 to 37 In the illustrated embodiment, the sampling needle driving mechanism 511 includes a first movable part 5111 and a second movable part 5112. The first movable part 5111 has a first driving working position and a second driving working position. The second movable part 5112 is driven connected or driven to cooperate with the first movable part 5111 and the puncture unit 40. When the first movable part 5111 is in its first driving working position, the puncture unit 40 is in its first puncture working state; when the first movable part 5111 is in its second driving working position, the puncture unit 40 is in its second puncture working state.

[0196] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 9-10 , Figures 13-16 , Figure 23-24 , Figure 26-30 , Figure 32-37 As shown, the puncture drive unit 50 includes a linkage part 52, which is driven to be connected to or driven to cooperate with at least two switching parts 51 so that the puncture units 40 corresponding to the at least two switching parts 51 move synchronously.

[0197] Setting up a linkage unit 52 that connects at least two switching units 51 is beneficial for achieving synchronous control of different puncture units 40.

[0198] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 8-11 , Figures 13-16 As shown, the puncture drive unit 50 includes a limiting portion 53 and / or a guide portion 54. The limiting portion 53 is configured to restrict the range of motion of the first movable portion 5111 and / or the second movable portion 5112. The guide portion 54 is configured to guide the movement of the first movable portion 5111 and / or the second movable portion 5112.

[0199] The puncture drive unit 50 includes a limiting part 53 and / or a guide part 54, which helps to prevent the puncture unit 40 from moving excessively by limiting the range of motion of the first movable part 5111 and / or the second movable part 5112, so that the puncture unit 40 can switch more accurately and quickly between the first puncture working state and the second puncture working state.

[0200] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 8-11 , Figures 13-16 As shown, the limiting part 53 is configured to limit the movement range of the linkage part 52 to limit the movement range of the first movable part 5111 and / or the second movable part 5112; and / or the guiding part 54 is configured to guide the movement of the linkage part 52 to guide the movement of the first movable part 5111 and / or the second movable part 5112.

[0201] The limiting part 53 limits the range of motion of the first movable part 5111 and / or the second movable part 5112 by limiting the range of motion of the linkage part 52, which is beneficial to achieve synchronous limiting of the puncture unit 40 that is linked by the linkage part 52, and can reduce the number of parts or structures used for limiting.

[0202] The guide section 54 is configured to guide the movement of the linkage section 52 to guide the movement of the first movable section 5111 and / or the second movable section 5112, which is beneficial to synchronously guide the piercing unit 40 that is linked by the linkage section 52, and can reduce the number of parts or structures used for guidance.

[0203] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 9-11 , Figure 13-16 As shown, the limiting part 53 includes one or more limiting structures, at least one limiting structure including a limiting groove 53A and a limiting surface 53B. The limiting surface 53B is movably located within the limiting groove 53A and has an abutment state with the limiting groove 53A. One of the limiting groove 53A and the limiting surface 53B is fixed relative to one of the first movable part 5111 and the second movable part 5112, and the other is fixed relative to the other of the first movable part 5111 and the second movable part 5112.

[0204] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 9-11 , Figure 13-16 As shown, the guide portion 54 includes one or more guide structures. At least one guide structure includes a guide groove 54A and a guide surface 54B. The guide surface 54B is slidably engaged with the guide groove 54A. One of the guide groove 54A and the guide surface 54B is fixed relative to the reagent chamber 10, and the other is fixed relative to the first movable portion 5111 or the second movable portion 5112.

[0205] At least one limiting structure of the limiting part 53 is configured to include a limiting groove 53A and a limiting surface 53B. The structure is simple and accurately limits the range of motion of the moving part to be controlled by the limiting part 53.

[0206] At least one guiding structure of the guide portion 54 is configured to include a guide groove 54A and a guide surface 54B. The structure is simple and facilitates accurate guidance of the movement direction of the moving part to be guided by the guide portion 54.

[0207] like Figure 13 and Figure 16 As shown, the limiting surface 53B is disposed on the limiting protrusion 531.

[0208] like Figure 4-6 , Figure 9-11 , Figure 13-16 As shown, the puncture drive unit 50 includes multiple guide structures, each guide structure including a guide groove 54A and a corresponding guide surface 54B. The guide groove 54A is disposed on the push-pull rod 521, and the guide surface 54B is a part of the surface of the support column 22 or is disposed on the guide pin 541 on the support column 22.

[0209] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 9-12 , Figure 14-15 As shown, the puncture drive unit 50 also includes a positioning part 55. The positioning part 55 has a positioning state that keeps the puncture unit 40 in a first puncture working state and / or a second puncture working state, and an avoidance state that prevents interference with the switching of the working position of the puncture unit 40. The positioning part 55 is movably disposed relative to the reagent chamber 10 to switch between the avoidance state and the positioning state.

[0210] The positioning unit 55 can switch between its positioning state and avoidance state, for example, by locking or unlocking the position of at least one of the first movable part 5111, the second movable part 5112, the linkage part 52, and the sample dispensing needle mounting part 42 of the puncture unit 40. For example, Figures 1 to 19 In the illustrated embodiment, the positioning unit 55 switches between its positioning state and avoidance state by locking and unlocking the position of the second movable unit 5112.

[0211] The positioning unit 55 is provided so that the second movable part 5112 can be stably maintained in the required position without the switching unit 51 continuously applying driving force to it. This allows the puncture device 40 to be stably in the second puncture working state, which helps to prevent interference between the reagent kit 30 and the puncture needle 41 of the puncture device 40 when the reagent kit 30 is changed.

[0212] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 9-12 , Figure 14-15 As shown, the positioning unit 55 is driven by the reagent kit 30 to switch between an avoidance state and a positioning state under the drive of the reagent kit 30.

[0213] For example, when the reagent kit 30 is placed in the reagent kit containing space 20A, the positioning part 55 is in a clearance state; when the reagent kit 30 is removed from the reagent kit containing space 20A, the positioning part 55 is in a positioning state.

[0214] The positioning part 55 can switch between avoidance and positioning states by means of the reagent kit 30, without the need for special operation of the positioning part 55, which simplifies the operation steps and ensures that the positioning part 55 is accurately in its required working state when the reagent kit 30 enters and exits the reagent kit accommodating space 20A.

[0215] In some embodiments of the reagent storage device 1, such as Figure 12 As shown, the positioning part 55 includes a slider 551 and a slider reset mechanism 552. The slider 551 is movably installed in the internal accommodating space of the reagent compartment 10 relative to the reagent compartment 10 and includes a positioning surface 5511D. The slider 551 is driven to cooperate with the reagent kit 30. In the avoidance state of the positioning part 55, the slider 551 is in the avoidance position where the positioning surface 5511D is separated from the second movable part 5112, and the slider reset mechanism 552 is in the charging state. In the positioning state of the positioning part 55, the slider 551 is in the positioning position where the positioning surface 5511D abuts against the second movable part 5112, and the slider reset mechanism 552 is in the releasing state.

[0216] exist Figures 1 to 19 In the embodiment shown, the slider reset mechanism 552 includes a spring located inside the slider 551 and pressing against the slider 511 and the support column 22 at both ends.

[0217] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 9-11 , Figure 13-16As shown, the first movable part 5111 includes a first translation component 51111, which is reciprocally movable relative to the reagent chamber 10 along a first direction X. The first translation component 51111 has a driving surface 51111A, which is inclined along the first direction X toward a second direction Z perpendicular to the first direction X. The second movable part 5112 includes a second translation component 51121, which is fixed relative to the sampling needle 41 and reciprocally movable relative to the reagent chamber 10 along the second direction Z. The second translation component 51121 has a mating surface 51121A corresponding to the driving surface 51111A, which is inclined along the first direction X toward the second direction Z. By changing the position of the first translation component 51111 in the first direction X, the mating position of the driving surface 51111A and the mating surface 51121A is changed, thereby changing the position of the second translation component 51121 along the second direction Z.

[0218] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 9-11 , Figure 13-16 As shown, the puncture drive unit 50 includes a linkage part 52, which is driven connected or driven to at least two switching parts 51 to make the puncture units 40 corresponding to the at least two switching parts 51 move synchronously. The linkage part 52 includes a push-pull rod 521 extending along a first direction X; a first translation member 51111 is fixed on the push-pull rod 521, and a driving surface 51111A is disposed on the side of the push-pull rod 521 near the second translation member 51121; the second translation member 51121 includes a pressure plate, which is arranged along a second direction Z, and a mating surface 51121A is disposed on the end of the pressure plate near the first translation member 51111.

[0219] The driving surface 51111A may include a curved surface and / or a plane, and the mating surface 51121A may also include a curved surface and / or a plane. The driving surface 51111A and the mating surface 51121A are, for example, planes, curved surfaces, combinations of planes, or combinations of planes and curved surfaces. Preferably, both the driving surface 51111A and the mating surface 51121A are mating arc surfaces or mating planes. The number of driving surfaces 51111A and mating surfaces 51121A can be set according to the driving requirements.

[0220] For example, such as Figure 4-6 , Figure 9-11 , Figure 13-16As shown, the first translation component 51111 includes a protrusion on the linkage part 52 (such as the push-pull rod 521), and the driving surface 51111A includes a curved surface, such as an arc surface, that protrudes from the linkage part 52 (such as the push-pull rod 521) toward the second translation component 51121 (such as the pressure plate) of the protrusion. Correspondingly, the mating surface 51121A includes a curved surface, such as an arc surface, that protrudes from the end of the second translation component 51121 (such as the pressure plate) toward the side away from the linkage part 52 (such as the push-pull rod 521).

[0221] As the linkage 52 (such as the push-pull rod 521) moves along the first direction X, when the curved surface on the linkage 52 (such as the push-pull rod 521) is located within the curved surface of the translation component (such as the pressure plate), that is, when the two curved surfaces are in convex-concave fit, the first translation component 51111 is in its first driving working position. At this time, the puncture end 41C of the sampling needle 41 of the puncture unit 40 enters the reagent storage space 30A. If the reagent kit 30 is contained in the reagent kit accommodating space 20A, the sampling needle hole 41B is connected to the reagent storage space 30A of the reagent kit 30. The required substance can be introduced into the reagent storage space 30A through the sampling needle 41 or the substance can be drawn out from the reagent accommodating space to the end of the sampling needle 41 away from the puncture end 41C.

[0222] As the linkage 52 (such as the push-pull rod 521) translates along the first direction X, when the curved surface on the linkage 52 (such as the push-pull rod 521) leaves the curved surface of the translation component (such as the pressure plate), that is, when the two curved surfaces are released from the convex-concave fit, the first translation component 51111 is in its second driving working position. At this time, the puncture end 41C of the sampling needle 41 of the puncture unit 40 leaves the reagent kit containing space 20A. If the reagent kit containing space 20A contains reagent kit 30, the needle hole 41B of the sampling needle is disconnected from the reagent storage space 30A of the reagent kit 30. At this time, it is impossible to introduce the required substance into the reagent storage space 30A through the sampling needle 41 or to draw the substance from the reagent containing space to the end of the sampling needle 41 away from the puncture end 41C.

[0223] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 9-11 , Figure 13-16 As shown, the puncture drive unit 50 includes a limiting part 53, which is configured to limit the movement range of the linkage part 52 to limit the movement range of the first movable part 5111. The limiting part 53 includes one or more limiting structures. At least one limiting structure includes a limiting groove 53A and a limiting surface 53B. The limiting surface 53B is movably located in the limiting groove 53A and has an abutment state with the limiting groove 53A. One of the limiting groove 53A and the limiting surface 53B is disposed on the second movable part 5112, and the other is disposed on the push-pull rod 521.

[0224] The limiting groove 53A and the limiting surface 53B of at least one limiting structure of the limiting part 53 are respectively arranged on the second movable part 5112 and the push-pull rod 521. This facilitates the accurate determination of the movement range of each movable component of the switching part 51 linked by the push-pull rod 521 and the movement range of the puncture unit 40 driven by the puncture unit 40 by limiting the movement range of the push-pull rod 521. This facilitates the synchronous driving of the puncture unit 40 driven by the push-pull rod 521 to switch quickly and accurately between the first puncture working state and the second puncture working state.

[0225] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 9-11 , Figure 13-16 As shown, the puncture drive unit 50 includes a guide portion 54, which is configured to guide the movement of the linkage portion 52 to guide the movement of the first active portion 5111. The guide portion 54 includes one or more guide structures, at least one of which includes a guide groove 54A and a guide surface 54B. One of the guide groove 54A and the guide surface 54B is fixed relative to the reagent chamber 10, and the other is disposed on the push-pull rod 521.

[0226] The guide groove 54A and guide surface 54B of at least one guide structure of the guide part 54 are fixed and arranged on the push-pull rod 521 relative to the reagent chamber 10, which facilitates the accurate guidance of the movement direction of the push-pull rod 521 and the movement of the first movable part 5111 of the switching part 51 linked to the push-pull rod 521. This facilitates the synchronous driving of the puncture unit 40 driven by the push-pull rod 521 to switch quickly and accurately between the first puncture working state and the second puncture working state.

[0227] In some embodiments of the reagent storage device 1, such as Figure 23-30 , Figure 32-37 As shown, the first movable part 5111 includes a first rotating component 51112, which is rotatably configured relative to the reagent chamber 10; the second movable part 5112 includes a second rotating component 51122, which is rotatably configured relative to the reagent chamber 10 and is drivenly connected to or driven to cooperate with the first rotating component 51112. The second rotating component 51122 drives the puncture unit 40 to switch between a first puncture working state and a second puncture working state.

[0228] The first movable part 5111 includes a first rotating component 51112, and the second movable part 5112 includes a second rotating component 51122. This allows the switching part 51 to perform its function through the rotating components, requiring a smaller operating range and reducing the operating space.

[0229] In some embodiments of the reagent storage device 1, such as Figure 23-30 , Figure 32-37 As shown, the first rotating component 51112 is a rotating shaft; the second rotating component 51122 includes a cam disposed on the rotating shaft, and the cam is in abutting engagement with the puncture unit 40.

[0230] In some embodiments of the reagent storage device 1, such as Figure 23-30 , Figure 32-37 As shown, the puncture drive unit 50 also includes a movable connection part 58, which is connected to the cam and the puncture unit 40 respectively, and is configured to transmit the motion of the cam to the puncture unit 40 so that the rotation of the cam drives the puncture unit 40 to move.

[0231] The movable connecting part 58 can effectively ensure that the cam 40 and the puncture unit 40 move synchronously, preventing the puncture unit 40 from jamming and failing to fit tightly with the cam 40. This ensures the stability and accuracy of the switching part 51 driving the puncture unit 40, and facilitates the timely and accurate switching of the working state of the puncture unit 40.

[0232] In some embodiments of the reagent storage device 1, such as Figures 29-30 As shown, the movable connecting part 58 includes a movable element 581, a first pin 582, and a second pin 583. The first pin 582 is disposed on the end face of the cam. The second pin 583 is disposed on the piercing unit 40 at a distance parallel to the first pin 582. The movable element 581 has an arc-shaped groove 581A. The movable element 581 is mounted on the cam and the piercing unit 40 through the first pin 582 and the second pin 583 engaging with the arc-shaped groove 581A. The first pin 582 and the second pin 583 are in sliding engagement with the arc-shaped groove 581A.

[0233] The movable connection 58 includes a movable element 581, a first pin 582, and a second pin 583, which simplifies the structure of the movable connection 58 and enables it to reliably perform the function of moving the puncture unit 40 and the cam.

[0234] In some embodiments of the reagent storage device 1, such as Figure 23-24 , Figure 26-29 , Figure 32-37 As shown, the puncture drive unit 50 includes a linkage part 52, which is driven to or engaged with at least two switching parts 51 by a first movable part 5111. The at least two switching parts 51 cause the puncture units 40 corresponding to the at least two switching parts 51 to move synchronously. The linkage part 52 includes, for example, at least one of a belt drive mechanism 522, a chain drive mechanism, a gear drive mechanism, a gear and rack drive mechanism, or a linkage mechanism connected between the at least two switching parts 51.

[0235] exist Figures 20 to 37In the illustrated embodiment, the linkage 52 includes a belt drive mechanism 522 connecting the rotating shafts of two puncture manipulation units corresponding to the same reagent kit accommodating space 20A. The belt drive mechanism 522 includes pulleys respectively connected to the two rotating shafts and a conveyor belt mounted on the two pulleys. The conveyor belt can be of various types, such as a V-belt, flat belt, synchronous belt, or multi-ribbed belt, etc., and the pulleys are matched with the conveyor belt.

[0236] exist Figures 20 to 37 In the illustrated embodiment, the first rotating element and the corresponding second rotating element are coaxially fixedly connected, such as a cam being directly fixedly connected to a rotating shaft. In embodiments not illustrated, the rotation axes of the first rotating element and the corresponding second rotating element can be set to be parallel or at an angle by a suitable transmission mechanism such as a gear transmission mechanism. For example, the rotating shaft and the cam can be driven connected by a transmission device to drive the cam to rotate via the rotating shaft.

[0237] In an embodiment not shown, the first movable part 5111 and the second movable part 5112 may each be a translational component and a rotational component, respectively. The translational and rotational components can be switched via a suitable transmission mechanism, such as a gear and rack mechanism, a cam-rod mechanism, or a linkage mechanism.

[0238] In some embodiments of the reagent storage device 1, the puncture drive unit 50 further includes an actuator 56, which is driven to be connected to or driven to cooperate with the first movable part 5111.

[0239] exist Figures 1 to 19 In the illustrated embodiment, the actuating part 56 includes a handle 561, which is driven connected to or driven to engage with the first movable part 5111. The handle 561 may, for example, be located on the side of the compartment 11 where the compartment door 12 is located.

[0240] exist Figures 20 to 37 In the illustrated embodiment, the actuating unit 56 includes a rotating handle 562, which is driven connected to or driven into cooperation with the first movable part 5111 (rotation shaft). The rotating handle 562 may, for example, be located on the side of the compartment 11 where the compartment door 12 is provided.

[0241] In embodiments not shown, an actuator may also be provided, which is driven connected to or driven in cooperation with the first movable part 5111. The actuator can replace the handle 561 or the rotary handle 562. The actuator may include, for example, a hydraulic cylinder, a pneumatic cylinder, a linear motor, a rotary motor, etc. If it is necessary to convert the output of the actuator into direction, speed, or force, an appropriate transmission mechanism may be provided between the actuator and the linkage or switching part. For example, the conversion between rotary motion and linear motion can be achieved through a gear and rack mechanism, a cam mechanism, or a lead screw and nut mechanism, etc., and the conversion of speed or force can be achieved through a gear pair, etc.

[0242] In some embodiments of the reagent storage device 1, such as Figure 4-6 , Figure 8-10 , Figure 14 , Figure 23-24 , Figure 26-29 , Figure 32 , Figure 34-37 As shown, the switching unit 51 includes a sampling needle driving mechanism 511 and a sampling needle resetting mechanism 512. One of the sampling needle driving mechanism 511 and the sampling needle resetting mechanism 512 is configured to apply a force to the puncture unit 40 to switch it from a first puncture working state to a second puncture working state; the other of the sampling needle driving mechanism 511 and the sampling needle resetting mechanism 512 is configured to apply a force to the puncture unit 40 to switch it from a second puncture working state to a first puncture working state.

[0243] The simultaneous installation of a sampling needle drive mechanism 511 and a sampling needle reset mechanism 512 facilitates the rapid and accurate switching of the puncture unit 40 between the first and second puncture working states, thereby ensuring accurate connection or disconnection between the sampling needle 41 and the corresponding reagent storage space 30A in the corresponding puncture working state.

[0244] like Figures 1 to 19 In the illustrated embodiment, the sampling needle drive mechanism 511 is configured to apply a force to the puncture unit 40, switching it from a first puncture operating state to a second puncture operating state. The sampling needle reset mechanism 512 is configured to apply a force to the puncture unit 40, switching it from the second puncture operating state to the first puncture operating state. Figures 20 to 37 In the illustrated embodiment, the sampling needle drive mechanism 511 is configured to apply a force to the puncture unit 40 to switch it from a second puncture working state to a first puncture working state. The sampling needle reset mechanism 512 is configured to apply a force to the puncture unit 40 to switch it from a first puncture working state to a second puncture working state.

[0245] In some embodiments of the reagent storage device 1, such as Figure 4-10 , Figure 14 , Figure 23-30 , Figures 31-37 As shown, the sample needle reset mechanism 512 includes at least one spring 5121; the spring 5121 is located and / or connected between the puncture unit 40 and the reagent storage unit 20; or the spring 5121 is located and / or connected between the reagent compartment 10 and the reagent compartment 10.

[0246] The sample needle reset mechanism 512 includes at least one spring 5121 to facilitate automatic reset of the puncture unit 40 without special operation.

[0247] The type of spring is not limited here, as long as it can achieve the corresponding reset function. For example, it can be a helical spring, and can be set as a tension spring or a compression spring depending on the installation position. It can also be a gas spring or a torsion spring, etc.

[0248] In embodiments not shown, the sample needle reset mechanism 512 may include, for example, an electromagnetic drive mechanism, a pneumatic mechanism, or a hydraulic mechanism.

[0249] In some embodiments of the reagent storage device 1, the reagent storage device 1 includes a plurality of reagent kit storage units 20, and / or the reagent kit storage units 20 include a plurality of reagent kit accommodating spaces 20A.

[0250] The reagent storage device 1 includes multiple reagent kit storage units 20, and each reagent kit storage unit 20 includes multiple reagent kit accommodating spaces 20A, which facilitates the simultaneous management and operation of multiple reagent kits and expands the functionality of the reagent storage device 1.

[0251] In some embodiments of the reagent storage device 1, the reagent storage device 1 further includes a heat preservation unit 60, which is configured to regulate the temperature of the reagent chamber 10.

[0252] The presence of a heat preservation unit 60 allows reagents to be stored at the required temperature, thus ensuring reagent quality.

[0253] In some embodiments of the reagent storage device 1, such as Figure 2 , Figure 4-8 , Figure 21 , Figure 23 , Figure 26-28 As shown, the insulation unit 60 includes a refrigerant circulation system 61.

[0254] The refrigerant circulation system 61 includes a compressor 612, a first heat exchanger 613, a throttling device, and a second heat exchanger 615, which are connected in sequence via refrigerant piping 611. To improve the heat exchange capacity of the first heat exchanger 613 and the second heat exchanger 615, a first fan 616 and a second fan 617 are also provided. A four-way valve for switching the refrigerant flow direction can also be provided, so that the refrigerant circulation system 61 can simultaneously perform cooling and heating functions, thereby helping to maintain the internal storage space of the reagent compartment 10 of the reagent storage device 1 at a temperature lower or higher than the ambient temperature.

[0255] like Figure 1 , Figure 3-6 , Figure 8-10 , Figure 14 , Figures 19-20 , Figure 22-29 , Figure 32 , Figures 34-35As shown, in some embodiments of the reagent storage device 1, the reagent storage device 1 includes a reagent kit 30, the reagent kit 30 includes a reagent storage space 30A, and the reagent kit accommodating space 20A of the reagent storage device 1 is used to place the reagent kit 30; in the first puncture working state of the puncture unit 40, the needle hole 41B of the sample dispensing needle is connected to the reagent storage space 30A of the reagent kit 30 placed in the reagent storage space 20A, and in the second puncture working state of the puncture unit 40, the needle hole 41B of the sample dispensing needle is disconnected from the reagent storage space 30A of the reagent kit 30 placed in the reagent storage space 20A.

[0256] In some embodiments of the reagent storage device 1, such as Figure 3-4 , Figure 6 , Figure 9 , Figure 14 , Figure 19 , Figure 22 , Figure 25-26 , Figure 34 As shown, the reagent kit 30 has a weak part 301 corresponding to the puncture end 41C of the sample dispensing needle 41. In the first puncture working state of the puncture unit 40, the puncture end 41C of the sample dispensing needle 41 enters the reagent storage space 30A by puncturing the weak part 301, so that the sample dispensing needle hole 41B of the sample dispensing needle 41 is connected to the reagent storage space 30A of the reagent kit 30.

[0257] To facilitate the insertion of the sample dispensing needle 41 into the reagent kit housing 31 to communicate with the reagent storage space 30A, a weak portion 301 can be provided at the site where the reagent kit housing 31 mates with the reagent needle, allowing for easy needle insertion. The weak portion 301 can be, for example, a portion of the housing wall of the reagent kit 31 other than the weak portion 301, thinner than the housing wall, or a portion of the housing wall made of a different material than the weak portion 301. The weak portion 301 can be easily replaceable to enable the reuse of the reagent kit 30. For example, an opening and a cover for closing the opening can be provided at the location of the reagent kit housing 31 corresponding to the reagent needle. The weak portion 301 can be the cover itself or a part of the cover. The cover can be, for example, a membrane or a cap.

[0258] like Figure 1-10 , Figure 14 , Figure 20-29 , Figure 32-37 As shown, in some embodiments of the reagent storage device 1, at least one puncture unit 40 is located within the internal containment space.

[0259] The reagent storage device 1 of this embodiment includes a puncture unit 40 within the reagent chamber 10. The needle hole 41B of the dispensing needle 41 of the puncture unit 40 can be connected to or disconnected from the reagent storage space 30A of the reagent kit 30. Thus, the puncture unit 40 can function as an external dispensing mechanism. By coupling the puncture unit 40 into the interior of the reagent chamber 10, compared to the prior art of external dispensing mechanisms in the reagent chamber 10, it is not necessary to reserve multiple through holes on the reagent chamber for the dispensing needle to pass through. This facilitates the isolation of the internal containment space of the reagent chamber 10 and the reagent kit 30 and puncture unit 40 within it from the air. Therefore, it helps to prevent a large amount of air from entering the reagent chamber, forming condensate, and then carrying dust and impurities into the reagent kit, contaminating the reagents.

[0260] like Figure 1 , 3 -6、 Figure 7 As shown, in some embodiments of the reagent storage device 1, the reagent storage device 1 further includes a base plate 70, which is located inside the reagent compartment 10 and installed on the bottom wall of the reagent compartment 10. The reagent kit storage unit 20 and / or the puncture unit 40 are installed on the base plate 70.

[0261] like Figures 1 to 19 In the illustrated embodiment, the components of the reagent storage device 1 located inside the reagent compartment 10, such as the reagent storage unit 20, the puncture unit 40, and the puncture drive unit 50, are all mounted on the base plate 70.

[0262] and Figures 1 to 19 The difference between the embodiments shown is that, Figures 20 to 37 In the illustrated embodiment, the components of the reagent storage device 1 located inside the reagent compartment 10, such as the reagent storage unit 20, the puncture unit 40, and the puncture drive unit 50, are all installed on the bottom wall of the compartment 11 of the reagent compartment 10, without a bottom plate.

[0263] A base plate 70 is provided inside the reagent compartment 10, which facilitates the assembly of the reagent storage device 1 into the internal storage space of the reagent compartment 10 after the partial structure is assembled, thereby enabling quick disassembly and maintenance.

[0264] like Figure 38 As shown, this disclosure also provides a reagent operating system, including the reagent storage device 1 of the foregoing embodiments of this disclosure. The reagent operating system further includes at least one of a reagent receiving unit 2, a cleaning solution delivery unit 3, and a gas communication unit 4. The reagent receiving unit 2 is in communication with the internal channel 41A of the sampling needle 41 of at least one puncture unit 40. The cleaning solution delivery unit 3 is in communication with the internal channel 41A of the sampling needle 41 of at least one puncture unit 40. The gas communication unit 4 is in communication with the internal channel 41A of the sampling needle 41 of at least one puncture unit 40.

[0265] The reagent operating system of this embodiment is coupled to the sampling needle 41 of the puncture unit 40 of the reagent storage device 1 via the reagent receiving unit 2 and / or the cleaning solution delivery unit 3 and / or the gas communication unit 4. This enables reagent sampling, output, and / or delivery of cleaning solution to the reagent storage space 30A to clean the sampling needle 41, and / or communication between the reagent storage space 30A and the external gas to allow reagents or cleaning solution to smoothly enter or exit the reagent storage space 30A. The reagent receiving unit 2 allows reagents from the reagent kit 30 to be introduced into the reagent receiving unit 2 for reagent transfer. The cleaning solution delivery unit 3 allows cleaning solution to be introduced into the reagent kit 30 to clean the sampling needle 41 that has come into contact with reagents, thus cleaning the sampling needle 41. The gas communication unit 4 allows gas to be introduced into the reagent storage space 30A of the reagent kit 30, thereby facilitating control of the pressure in the reagent storage space 30A and consequently, control of the reagent outflow rate.

[0266] In some embodiments of the reagent operating system, the reagent operating system includes a reagent receiving unit 2 and a cleaning solution delivery unit 3, which are respectively connected to the internal channels 41A of the sample dispensing needles 41 of different puncture units 40; and / or the reagent operating system includes a cleaning solution delivery unit 3 and a gas communication unit 4, which are connected to the internal channels 41A of the sample dispensing needles 41 of the same puncture unit 40 at different times.

[0267] In some embodiments of the reagent operating system, the reagent operating system includes a reagent receiving unit 2 and a cleaning solution delivery unit 3. Specifically, the puncture end 41C of the sampling needle 41 of the puncture unit 40 in the reagent receiving unit 2, which is in communication with the reagent receiving unit 2, is located at the bottom outer side or below the corresponding reagent kit accommodating space 20A; the puncture end 41C of the sampling needle 41 of the puncture unit 40 in communication with the cleaning solution delivery unit 3 is located at the top outer side or above the corresponding reagent kit accommodating space 20A.

[0268] The above design allows the sample needle 41 for extracting reagents to penetrate only a shallow depth into the reagent kit 30, thus emptying the reagents in the corresponding reagent storage space 30A. This allows for cleaning of the sample needle 41 for extracting reagents with less cleaning solution, while the sample needle 41 for introducing cleaning solution will not come into contact with the reagents and will not be contaminated by them.

[0269] In some embodiments of the reagent operating system, the reagent receiving unit 2 is connected to the sampling needle 41 of at least one puncture unit 40 via a connecting tube having a flexible section or a telescopic section; and / or the cleaning fluid delivery unit 3 is connected to the sampling needle 41 of at least one puncture unit 40 via a connecting tube having a flexible section or a telescopic section; and / or the gas communication unit 4 is connected to the sampling needle 41 of at least one puncture unit 40 via a connecting tube having a flexible section or a telescopic section.

[0270] The end of the sampling needle 41 away from the puncture needle hole 41B can be connected to one end of a connecting tube including a flexible tube segment or a telescopic tube segment. The other end of the connecting tube is connected to or passes through a perforation on the reagent compartment 10. The reagent receiving part 2, the cleaning solution delivery part 3, or the gas communication part 4 located outside the reagent storage device 1 can be connected to the other end of the perforation or the connecting tube, thereby connecting to the sampling needle 41. Due to the flexibility of the connecting tube including the flexible tube segment or the telescopic performance of the connecting tube including the telescopic tube segment, the position change of the sampling needle 41 caused by the switching of the working position of the puncture unit 40 does not affect the connection with the reagent receiving part 2, the cleaning solution delivery part 3, or the gas communication part 4 and the second end of the connecting tube, or does not affect the connection with the perforation on the reagent compartment 10.

[0271] In some embodiments of the reagent operating system, the reagent receiving unit 2 is connected to the sampling needle 41 of at least one puncture unit 40 via a connecting tube that passes through the reagent chamber 10 and is sealed between the reagent chamber 10 and the reagent chamber 10; and / or the cleaning solution delivery unit 3 is connected to the sampling needle 41 of at least one puncture unit 40 via a connecting tube that passes through the reagent chamber 10 and is sealed between the reagent chamber 10 and the reagent chamber 10; and / or the gas communication unit 4 is connected to the sampling needle 41 of at least one puncture unit 40 via a connecting tube that passes through the reagent chamber 10 and is sealed between the reagent chamber 10 and the reagent chamber 10.

[0272] Since the connecting tubes of the reagent receiving section 2 and / or the cleaning solution delivery section 3 and / or the gas communication section 4 and the sample needle 41 are sealed with the reagent chamber 10, it can better prevent external air from entering the reagent chamber 10. This helps to prevent air from entering the internal containment space of the reagent chamber 10 through the gap between the connecting tube and the reagent chamber 10, forming condensate, and then carrying dust and impurities into the reagent kit and contaminating the reagents.

[0273] The following combination Figures 1 to 38 The embodiments of this disclosure will be described in detail.

[0274] In the following description of embodiments of this disclosure, "front" refers to the side where the compartment door is located, corresponding to... Figure 1 and Figure 20 The X direction in the text corresponds to the aforementioned first direction; "back" refers to the side opposite to "front"; "up" and "down" refer to the vertical direction when the reagent storage device 1 is normally placed, with "up" corresponding to... Figure 1 and Figure 20 The Z direction, which corresponds to the second direction mentioned above, is described as "top" and "bottom" respectively in the following descriptions; "left" and "right" refer to the left and right directions when viewed from "front" to "back", with "right" corresponding to... Figure 1 The Y direction in the equation can also be called the third direction.

[0275] Figures 1 to 19 A reagent storage device 1 according to an embodiment of the present disclosure is shown. For example... Figures 1 to 19 In the embodiment shown, the reagent storage device 1 includes a reagent compartment 10, a reagent kit storage unit 20, a reagent kit 30, a puncture unit 40, a puncture drive unit 50, a heat preservation unit 60, and a base plate 70.

[0276] The reagent compartment 10 includes a compartment body 11 and a compartment door 12 for closing the compartment body 11. The compartment body 11 is a cube with its opening facing the front side of the compartment body 11. The compartment body 11 forms an internal receiving space for the reagent compartment 1, and the internal receiving space is sealed when the compartment door 12 is closed. The compartment door 12 is hinged to the front end of the right side wall of the compartment body 11.

[0277] The reagent storage unit 20, reagent kit 30, puncture unit 40, puncture drive unit 50, insulation unit 60, and base plate 70 are all located within the internal accommodating space. The base plate 70 is installed on the bottom wall of the chamber 11, and the reagent storage unit 20, reagent kit 30, puncture unit 40, puncture drive unit 50, and insulation unit 60 are all installed on the base plate 70.

[0278] The reagent storage device 1 includes two reagent kit storage units 20 arranged side by side. Each reagent kit storage unit 20 includes a reagent kit accommodating space 20A, which is configured to hold a reagent kit 30 having a reagent storage space 30A.

[0279] Each reagent kit storage unit 20 includes two parallel, upper and lower square reagent kit protective plates serving as reagent kit protective sections 21, and four connecting rods 22. The reagent kit protective plates have puncture end clearance openings 21A to avoid the puncture end 41C of the sample dispensing needle 41. A connecting rod 22 is provided at each of the four corners of the upper and lower reagent kit protective plates, and each connecting rod 22 is fixedly connected to the upper and lower reagent kit protective plates. Each connecting rod 22 passes through both upper and lower reagent kit protective plates. The upper and lower ends of the connecting rod 22 are located above and below the upper and lower reagent kit protective plates, respectively. The bottom end of the connecting rod 22 is fixedly connected to the base plate 70. The bottom end of the connecting rod 22 is fixedly connected to the base plate 70 by means such as welding, threaded connection, or connection via a connector. The portion of the connecting rod 22 located between the two reagent kit protective plates is a square segment with a square cross-section, while the portions of the connecting rod 22 located above and below the two reagent kit protective plates are circular segments. The space defined by the upper and lower reagent kit protective plates and the four connecting rods 22 constitutes the reagent kit accommodating space 20A. In embodiments not shown, the cross-sectional shape of the connecting rods 22 can be either square from top to bottom or circular from top to bottom.

[0280] The reagent kit 30 includes multiple reagent storage spaces 30A. The reagent kit 30 includes multiple reagent kit bodies 31, and each reagent kit body 31 includes a single reagent storage space 30A.

[0281] like Figure 19 As shown, the reagent kit 30 also includes a mounting frame 32 and a cover plate 33. The mounting frame 32 includes a square frame body and multiple partitions. The partitions divide the space within the frame body into multiple independent areas corresponding to multiple reagent kit boxes 31. Each reagent kit box 31 has an open top and is mounted on the lower part of the mounting frame 32, and is sealed to the partition of the corresponding independent area and the top of the frame body. The cover plate 33 covers the mounting frame 32 and is sealed to the frame body and the top of the partitions. The cover plate 33 has multiple weak points 301 corresponding to each independent area and the corresponding reagent kit box 31. Each reagent kit box 31 has an opening in its bottom wall, and each opening has a corresponding plug 34 that is inserted into the opening. The plug 34 has a weak point 301. After the reagent kit 30 is installed in the reagent kit accommodating space 20A, each weak point 301 is opposite to the corresponding sample dispensing needle 41.

[0282] The reagent storage device 1 includes four puncture units 40, with two puncture units 40 corresponding to each reagent kit storage unit 20. In the two puncture units 40 corresponding to the same reagent kit accommodating space 20A, the puncture tip 41C of the sample dispensing needle 41 of one puncture unit 40 is located below the corresponding reagent kit accommodating space 20A, and the puncture tip 41C of the sample dispensing needle 41 of the other puncture unit 40 is located above the corresponding reagent kit accommodating space 20A.

[0283] The puncture unit 40 includes a sampling needle mounting part 42 and a plurality of sampling needles 41 fixed on the sampling needle mounting part 42. The sampling needle mounting part 42 is a mounting plate.

[0284] The sample application needle 41 has an internal channel 41A and a puncture end 41C. The puncture end 41C is provided with a sample application needle hole 41B that communicates with the internal channel 41A.

[0285] The puncture unit 40 is movably disposed relative to the reagent storage unit 20 and has a first puncture working state and a second puncture working state. With the reagent kit 30 placed in the reagent accommodating space 20A, in the first puncture working state, the sample dispensing needle orifice 41B is connected to the reagent storage space 30A of the reagent kit 30, and in the second puncture working state, the sample dispensing needle orifice 41B is disconnected from the reagent storage space 30A of the reagent kit 30.

[0286] In this configuration, the puncture tip 41C of the sample dispensing needle 41 of the puncture unit 40 located below the reagent kit containing space 20A is also located below the corresponding reagent kit containing space 20A. The lower puncture unit 40 is used to extract reagents from the reagent kit 30. The puncture tip 41C of the sample dispensing needle 41 of the puncture unit 40 located above the same reagent kit containing space 20A is also located above the corresponding reagent kit containing space 20A. The upper puncture unit 40 is used to communicate with gas to facilitate the extraction of reagents from the lower puncture unit 40, and also to allow cleaning solution to be introduced into the reagent storage space 30A after the reagents from the lower puncture unit 40 have been extracted, in order to clean the sample dispensing needle 41 of the lower puncture unit 40.

[0287] like Figure 17 and Figure 18 As shown, the sampling needle 41 of the puncture unit 40 includes a sampling needle tube 411 and a sampling needle tip 412. An internal channel 41A is located within the sampling needle tube 411. The sampling needle tip 412 is located at the puncture end 41C of the sampling needle 41 and is connected to one end of the sampling needle tube 411. The sampling needle tip 412 is a cone whose cross-section gradually decreases from the sampling needle tube 411 towards the side away from the sampling needle tube 411. The sampling needle orifice 41B is located on the side wall of the sampling needle tube 411 near the sampling needle tip 412.

[0288] The sample dispensing needle tube 411 includes a first straight sample dispensing needle section 4111, a bent sample dispensing needle section 4112, and a second straight sample dispensing needle section 4113. The bent sample dispensing needle section 4112 is a flexible section. The first straight sample dispensing needle section 4111 extends along the surface of the chamber wall of the chamber 11 in a first direction X. The second straight sample dispensing needle section 4113 extends from one side of the chamber wall of the chamber 11 toward the reagent kit accommodating space 20A, i.e., along a second direction Z. One end of the second straight sample dispensing needle section 4113 is connected to one end of the first straight sample dispensing needle section 4111 via a bent sample dispensing needle section 4112, and the sample dispensing needle tip 412 is connected to the other end of the second straight sample dispensing needle section 4113. Each sample dispensing needle 41 is mounted on a sample dispensing needle mounting part 42 via its fixing connection part 413. The fixing connection part 413 and the sample dispensing needle mounting part 42 are, for example, threaded connections or interference fits.

[0289] The reagent storage device 1 includes two puncture drive units 50. Each puncture drive unit 50 is correspondingly configured with one reagent kit storage unit 20 and is drivenly connected to the two corresponding puncture units 40 of the corresponding reagent kit storage unit 20.

[0290] Each puncture drive unit 50 includes a switching part 51, a linkage part 52, a limiting part 53, a guide part 54, a positioning part 55, and an actuating part 56.

[0291] Each puncture drive unit 50 includes two switching parts 51 corresponding to two puncture units 40. Each switching part 51 is driven connected or driven to cooperate with the corresponding puncture unit 40 and is configured to drive the puncture unit 40 to switch between a first puncture working state and a second puncture working state. The two switching parts 51 are linked together by a linkage part 52 to simultaneously drive the two puncture units 40 corresponding to the same reagent kit accommodating space 20A to operate, so that the two puncture units 40 synchronously switch from the first puncture working state to the second puncture working state or from the second puncture working state to the first puncture working state.

[0292] In this embodiment, multiple sampling needles 41 of each puncture unit 42 are mounted on the sampling needle mounting part 42. The switching part 51 is driven to connect or drive to cooperate with the sampling needle mounting part 42 of the puncture unit 40 to drive the multiple sampling needles 41 to move synchronously.

[0293] The switching unit 51 includes a sampling needle drive mechanism 511 and a sampling needle reset mechanism 512. The sampling needle drive mechanism 511 applies a force to the puncture unit 40 to switch it from a first puncture working state to a second puncture working state. The sampling needle reset mechanism 512 applies a force to the puncture unit 40 to switch it from the second puncture working state to the first puncture working state.

[0294] The sample dispensing needle drive mechanism 511 includes a first movable part 5111 and a second movable part 5112. The first movable part 5111 has a first driving working position and a second driving working position. The second movable part 5112 is driven connected to or driven to cooperate with the first movable part 5111 and the puncture unit 40, as shown in the reference. Figures 14 to 16 When the first active part 5111 is in its first driving working position, the puncture unit 40 is in its first puncture working state, referencing Figure 4-6 , Figure 8-11 When the first active part 5111 is in its second driving working position, the puncture unit 40 is in the second puncture working state.

[0295] Each sample dispensing needle drive mechanism 511 has a first movable part 5111 including four first translational components 51111, with two first translational components 51111 on each of the front and rear sides of the reagent kit storage unit 20. The two first translational components 51111 on each side of the reagent kit storage unit 20 are arranged at intervals along the front-rear direction. Each first translational component 51111 is reciprocally movable relative to the compartment 11 along a first direction X, and each first translational component 51111 has a driving surface 51111A, which is inclined along the first direction X toward a second direction Z perpendicular to the first direction X.

[0296] Each sample dispensing needle drive mechanism 511's second movable part 5112 includes two second translational components 51121, one on each of the left and right sides of the reagent kit storage unit 20. Each second translational component 51121 is fixedly connected to the corresponding sample dispensing needle mounting part 42, thereby being fixedly positioned relative to the sample dispensing needle 41. Each second translational component 51121 is also reciprocally movable relative to the chamber 11 along the second direction Z. Each second translational component 51121 has two mating surfaces 51121A that correspond one-to-one with the two driving surfaces 51111A of the corresponding first translational component 51111 on one side. The mating surfaces 51121A are inclined along the first direction X toward the second direction Z. By changing the position of the first translational component 51111 in the first direction X, the mating position of the driving surface 51111A and the corresponding mating surface 51121A is changed, thereby changing the position of the second translational component 51121 along the second direction Z.

[0297] Each sample needle reset mechanism 512 includes four springs 5121, which are located at the four corners of the reagent kit storage unit 20. Each spring 5121 is sleeved on the connecting rod 22 at the corresponding corner. The corresponding end of the connecting rod 22 passes through the sample needle mounting part 42, and a portion of the rod extends outside the sample needle mounting part 42. The spring 5121 is sleeved on the outer portion of the rod of the sample needle mounting part 42. One end of the spring 5121 abuts against the corresponding sample needle mounting part 42, and the other end presses against the spring seat 5122. The spring seat 5122 is fixed to the end of the connecting rod 22 by a threaded connector. Each spring 5121 is a compression spring, which applies a force to the sample needle mounting part 42 so that it is directed toward the reagent storage unit 20. The sample needle mounting part 42 also applies a force to the second translation member 51121 so that it is directed toward the push-pull rod 521. When the push-pull rod 521 is in the rearward extreme position, each driving surface 51111A and the corresponding mating surface 51121A are in a convex-concave mating state. This is beneficial because when the sample needle mounting part 42 is in the first puncture working state of the puncture unit 40, the sample needle mounting part 42 and the sample needle 421 on it are both in the designated position, preventing the sample needle 421 from not being effectively connected to the corresponding reagent storage space 30A.

[0298] The linkage 52 is driven to connect with or engage with the two switching units 51 to synchronize the movement of the corresponding puncture units 40. The linkage 52 includes two push-pull rods 521 extending along the first direction X. The two push-pull rods 521 are located on the left and right sides of the reagent storage unit 20, respectively. The first translation components 51111 of each of the two puncture units 40 are fixed to the push-pull rod 521 on the same side. The driving surface 51111A is provided on the side of the push-pull rod 521 near the corresponding second translation component 51121. The second translation component 51121 includes a pressure plate arranged along the second direction Z, and the mating surface 51121A is provided on the end of the pressure plate near the corresponding first translation component 51111.

[0299] The first translation component 51111 is a protrusion provided on the push-pull rod 521, and the driving surface 51111A is an arc-shaped surface of the protrusion that protrudes from the push-pull rod 521 toward the pressure plate side. Correspondingly, the mating surface 51121A includes an arc-shaped surface provided on the pressure plate that protrudes toward the side away from the push-pull rod 521 at the end facing the push-pull rod 521 side.

[0300] As the push-pull rod 521 translates in the front-to-back direction, when the driving surface 51111A on the push-pull rod 521 is located within the mating surface 51121A on the pressure plate, that is, when the two arc-shaped surfaces of the driving surface 51111A and the mating surface 51121A respectively engage in a convex-concave fit, the first translation component 51111 is in its first driving working position (e.g., Figure 14-16 As shown), at this time, the puncture end 41C of the sampling needle 41 of the puncture unit 40 enters the reagent storage space 20A. If the reagent storage space 20A contains the reagent kit 30, the tip 412 of the sampling needle pierces the corresponding reagent body 31, and the needle hole 41B of the sampling needle is connected to the corresponding reagent storage space 30A of the reagent body 31. Thus, the required substance can be introduced into the reagent storage space 30A through the sampling needle 41 or the substance can be drawn out from the reagent storage space 20A to the end of the sampling needle 41 away from the puncture end 41C.

[0301] As the push-pull rod 521 translates along the front-to-back direction, when the arc-shaped surface on the push-pull rod 521 moves away from the arc-shaped surface of the pressure plate, that is, when the two arc-shaped surfaces disengage from the convex-concave fit, the first translation component 51111 is in its second driving working position (e.g., Figure 4-6 , Figure 9-11 , Figure 12As shown), at this time, the puncture end 41C of the sampling needle 41 of the puncture unit 40 leaves the reagent kit containing space 20A. If the reagent kit containing space 20A contains reagent kit 30, the tip 412 of the sampling needle separates from the corresponding reagent kit body 31, and the needle hole 41B of the sampling needle is disconnected from the reagent storage space 30A corresponding to the reagent kit body 31. At this time, it is impossible to introduce the required substance into the reagent storage space 30A through the sampling needle 41 or to draw the substance from the reagent containing space to the end of the sampling needle 41 away from the puncture end 41C.

[0302] The limiting part 53 is configured to limit the range of motion of the first movable part 5111 and the second movable part 5112. In this embodiment, the limiting part 53 limits the range of motion of the first movable part 5111 and the second movable part 5112 by limiting the range of motion of the push-pull rod 521, which is a linkage part 52.

[0303] like Figure 4-6 , Figure 9-11 , Figure 13-16 As shown, the limiting part 53 of each puncture drive unit 50 includes four limiting structures, which are grouped in pairs, with each pair of limiting structures located on the upper and lower sides of a push-pull rod 521. Each limiting structure includes a limiting groove 53A and a limiting surface 53B. The limiting surface 53B is movably located within the limiting groove 53A and has an abutment state with the limiting groove 53A. The limiting groove 53A is disposed on the second movable part 5112, which in this embodiment is disposed on the pressure plate, and the limiting surface 53B is disposed on the push-pull rod 521, which serves as the linkage part 52. Specifically, the push-pull rod 521 is provided with a limiting protrusion 531 facing the pressure plate, and the limiting surface 53B is a portion of the surface of the limiting protrusion 531.

[0304] like Figure 4-6 , Figure 9-11 , Figure 13-16As shown, each push-pull rod 521 has a limiting protrusion 531 on its upper and lower sides. The limiting protrusion 531 is hook-shaped, including a main body connected to the push-pull rod 521 and a hook portion protruding from the side away from the push-pull rod 521 towards the first direction X. The surface of the hook portion facing the push-pull rod 521 is inclined outward from the main body in the direction from the side close to the push-pull rod 521 towards the side away from the push-pull rod 521. This surface of the hook portion facing the push-pull rod 521 forms part of the limiting surface 53B. The surface of the main body on the side opposite to the hook portion forms another part of the limiting surface. A limiting groove 53A is provided on one side of the pressure plate corresponding to each limiting protrusion 531. The limiting groove 53A includes a first groove segment near the push-pull rod 521 and a second groove segment connected to the first groove segment on the side away from the push-pull rod 521. The width of the second groove segment along the first direction X is greater than the width of the first groove segment along the first direction X. The first groove segment and the second groove segment are connected by a stepped surface. The limiting protrusion 531 is located in the limiting groove 53A, and the limiting protrusion 531 has a movable allowance in the limiting groove 53A along the first direction X.

[0305] When the push-pull rod 521 moves from the front to the rear, the hook, driven by the push-pull rod 521, approaches and finally abuts against the intersection of the stepped surface of the rear side of the limiting groove 53A and the first groove segment. After abutting, the limiting structure 53 prevents the push-pull rod 521 from continuing to move backward, thereby limiting the backward movement of the first translation component 51111 by limiting the push-pull rod 521. In addition, the hook restricts the movement of the second translation component 51121 away from the push-pull rod, thus also limiting the upward movement of the second translation component 51121.

[0306] When the push-pull rod 521 moves from the rear to the front, the surface of the hook on the side of the push-pull rod 521, driven by the push-pull rod 521, gradually moves away from the stepped surface of the limiting groove 53A, releasing the restriction on the movement of the second translation component 51121 away from the push-pull rod. The second translation component 51121 can move along the second direction Z away from the push-pull rod 521 under the drive of the push-pull rod 521 and the first translation component 51111 on it. As the push-pull rod 521 continues to move forward, the surface of the main body of the limiting protrusion 531 opposite to the hook abuts against the right side wall of the first groove section of the limiting groove 53A. After abutting, the limiting structure 53 prevents the push-pull rod 521 from continuing to move to the right, thereby limiting the forward movement of the first translation component 51111 by limiting the push-pull rod 521.

[0307] like Figure 4-6 , Figure 9-11 , Figure 13-16As shown, the guide portion 54 is configured to guide the movement of the first movable portion 5111 along the first direction X. In this embodiment, the guide portion 54 guides the movement of the first movable portion 5111 by guiding the movement of the push-pull rod 521, which serves as the linkage portion 52.

[0308] like Figure 4-6 , Figure 9-11 , Figure 13-16 As shown, the guide part 54 includes multiple guide structures, each guide structure including a guide groove 54A and a corresponding guide surface 54B. The guide surface 54B slides with the corresponding guide groove 54A. The guide surface 54B is fixed relative to the compartment 11, and the guide groove 54A is fixed relative to the first movable part 5111. For example, in this embodiment, the guide groove 54A is provided on the push-pull rod 521.

[0309] like Figure 4-6 , Figure 9-11 , Figure 13-16 As shown, the puncture drive unit 50 has two guide structures at each of the front and rear ends of each push-pull rod 521. In one of the guide structures at each end of each push-pull rod 521, a guide groove 54A is provided on the push-pull rod 521 with the groove direction being the second direction Z. The support column 22 of the reagent storage unit 20, extending along the second direction Z, passes through the guide groove 54A. The surface of the support column 22 along the third direction Y slides in cooperation with the guide groove 54A and has a certain amount of movement within the guide groove 54A along the first direction X. In the other guide structure at each end of each push-pull rod 521, the guide groove 54A is on the push-pull rod 521 with the groove direction being the third direction Y. The corresponding guide surface 54B is provided on the guide pin 541. The guide pin 541 is axially in the third direction Y, is located within the corresponding guide groove 54A, slides in cooperation with the guide groove 54A, and has a certain amount of movement within the guide groove 54A along the first direction X.

[0310] exist Figures 1 to 19 In the illustrated embodiment, the linkage 52 is movably mounted on the support column 22 via the guide pin 541. Furthermore, by appropriately setting the length and position of the guide groove 54A corresponding to the guide pin 541, so that the front and rear limit positions of the relative movement of the guide pin 541 within the guide groove 54A precisely correspond to the second and first driving working positions of the first translation component 51111 on the push-pull rod 521, the guide pin 541 and the corresponding guide groove 54A can also limit the movement of the first movable part 5111 along the first direction X. Similarly, the connecting rod 22 and the corresponding guide groove 54A can also limit the movement of the first movable part 5111 along the first direction X through the appropriate setting of the length and position of the guide groove 54A.

[0311] like Figure 4-6 , Figure 9-12 , Figure 14-15 As shown, the positioning unit 55 has a positioning state that keeps the puncture unit 40 in the second puncture working state and an avoidance state that prevents interference with the switching of the working position of the puncture unit 40. The positioning unit 55 is movably disposed relative to the chamber body 11 to switch between the avoidance state and the positioning state.

[0312] The positioning unit 55 switches between a positioning state and an avoidance state by locking and unlocking the position of the second movable unit 5112. When the first movable unit 5111 is in its second drive operating position, the positioning unit 55 is in the positioning state. When the first movable unit 5111 switches between the first drive operating position and the second drive operating position, the positioning unit 55 is in the avoidance state.

[0313] The positioning part 55 is driven to cooperate with the reagent kit 30 to switch between a clearance state and a positioning state under the action of the reagent kit 30. When the reagent kit 30 is placed in the reagent kit containing space 20A, the positioning part 55 is in the clearance state, and when the reagent kit 30 is removed from the reagent kit containing space 20A, the positioning part 55 is in the positioning state.

[0314] like Figure 12 As shown, the positioning part 55 includes a slider 551 and a slider reset mechanism 552. The slider 551 is movably installed within the compartment 11 relative to the compartment 11 and includes a positioning surface 5511D. The slider 551 is driven to cooperate with the reagent kit 30. In the avoidance state of the positioning part 55, the slider 551 is in an avoidance position where the positioning surface 5511D is separated from the second movable part 5112. The slider reset mechanism 552 is in a charging state. In the positioning state of the positioning part 55, the slider 551 is in a positioning position where the positioning surface 5511D abuts against the second movable part 5112. The slider reset mechanism 552 is in a releasing state. In this embodiment, the positioning part 55 of each puncture driving unit 50 includes two positioning mechanisms. The two positioning mechanisms are respectively located at the rear of the left and right sides of the reagent kit storage unit 20, and each positioning mechanism is respectively installed on the support column 22 on the corresponding side.

[0315] The following combination Figures 11 to 12 The structure of the positioning mechanism is described. For example... Figure 11 and Figure 12 As shown, the positioning mechanism includes the aforementioned slider 551, slider reset mechanism 552, and slider mounting pin 553.

[0316] like Figure 12 As shown, the slider 551 includes two parallel, spaced-apart first blocks 5511 and a second block 5512 connected at right angles to the two first blocks 5511. The slider 551 is movably mounted on the support column 22.

[0317] The rear section of the push-pull rod 521 is located within the gap between the two first blocks 5511, and the push-pull rod 521 is slidably engaged with the slider 551. Therefore, the push-pull rod 521 defines the position of the slider 551 along the second direction Z and its movement along the first direction X. Each first block 5511 of the slider 551 is also provided with a first slider groove 5511A and a second slider groove 5511B. The slotting direction of the first slider groove 5511B is the second direction Z. The corresponding support column 22 passes through the first slider groove 5511B of the two first blocks 5511, is slidably connected to the first slider groove 5511B, and has a certain amount of movement along the first direction X in the first slider groove 5511B. The slotting direction of the second slider groove 5511B is the third direction Y, and two slider mounting pins 553 are respectively provided corresponding to the second slider grooves 5511B of the two first blocks 5511. The slider mounting pin 553 is axially in the third direction Y, is mounted on the support column 22 and located in the second slider groove 5511B. The slider mounting pin 553 slides in the second slider groove 5511B and has a certain amount of movement along the first direction X. Thus, the slider 551 is movably mounted on the support column 22 via the slider mounting pin 553 and the push-pull rod 521.

[0318] In this embodiment, the front and rear limit positions of the slider mounting pin 553 within the second slider groove 5511B determine the limit positions of the slider 551.

[0319] exist Figures 1 to 19 In the illustrated embodiment, the slider reset mechanism 552 includes a spring located inside the slider 551, with its two ends respectively pressing against the slider 511 and the support column 22. In this embodiment, each first block 5511 has a spring mounting hole 5511C extending along the first direction X, and a spring is installed in the spring mounting hole 5511C. The spring mounting hole 5511C communicates with the first slider groove 5511A, so that one end of the spring abuts against the support column 22 to apply force to the support column 22. To facilitate spring installation and spring elasticity adjustment, a threaded hole can be opened at the end of the spring mounting hole 5511C, and a screw that mates with the threaded hole can be installed in the threaded hole. The screw abuts against one end of the spring, and when the position of the screw in the threaded hole is adjusted, the elasticity of the spring is adjusted accordingly.

[0320] The positioning surface 5511D is disposed at the end of each first block 5511 that is away from the second block 5112. The end of the first block 5511 that is away from the second block 5512 includes a stepped surface facing the corresponding puncture unit 40, and the stepped surface forms the positioning surface 5511D.

[0321] The second block 5512 is opposite to the rear of the reagent kit accommodating space 20A and is located within the reagent kit accommodating space 20A when the slider reset mechanism 552 is in the stress-releasing state. As the reagent kit 30 moves from front to back and is gradually pushed into the reagent kit accommodating space 20A, it gradually approaches and contacts the second block 5512. After contact, the second block 5512 gradually moves backward under the push of the reagent kit 30. During the backward movement of the second block 5512, the positioning surface 5511D of the slider 551 moves backward accordingly and the overlap between it and the second movable part 5112 in the first direction X gradually decreases until they separate and are in a clearance position. Figure 14 As shown, at this time, the slider reset mechanism 552 is in a charging state. In the charging state, the slider reset mechanism 552 is subjected to the maximum force, just like a spring.

[0322] Before the reagent kit 30 is removed from the reagent kit containing space 20A, the push-pull rod 521 needs to be pulled forward, so that the first translation component 51111 arranged on the push-pull rod 521 moves forward accordingly. The two upper and lower second translation components 51121 on the left and the two upper and lower second translation components 51121 on the right move upward and to the sides respectively, so that each puncture unit 40 is in the second puncture working state. When the reagent kit 30 is removed from the reagent kit containing space 20A, it gradually moves forward. Due to the action of the spring of the positioning part 55, the second block 5512 and the slider 551 move forward with the reagent kit 30 until they are limited by the slider mounting pin 553 and the second slider groove 5511B. The slider 551 no longer moves with the reagent kit 30. At this time, the slider reset mechanism 552 of the positioning part 55 is in the stress-relieving state. In the stress-relieving state, the slider reset mechanism 552, like a spring, experiences the least force.

[0323] exist Figures 1 to 19 In the embodiment shown, the actuation part 56 of each puncture drive unit 50 includes a handle 561. The handle 561 is driven to be connected or driven to cooperate with the first movable part 5111 of the switching part 51. The handle 561 is located on the side of the chamber 11 where the chamber door 12 is provided, that is, on the front side.

[0324] The handle 561 has a U-shaped structure, comprising two parallel, spaced-apart first handle rods and a second handle rod connecting the two first handle rods. The two first handle rods extend vertically and are positioned on the left and right sides of the reagent kit accommodating space 20A, respectively. The free end of each first handle rod is fixedly connected to the front end of the push-pull rod 521. The second handle rod extends horizontally and is located above the reagent kit accommodating space 20A. The U-shaped handle 561 avoids obstructing the inlet and outlet of the reagent kit 30 at the front end of the reagent kit accommodating space 20A.

[0325] The insulation unit 60 is configured to regulate the temperature of the reagent chamber 10. The insulation unit 60 includes a refrigerant circulation system 61. The refrigerant circulation system 61 includes a compressor 612, a first heat exchanger 613, a throttling device, and a second heat exchanger 615, which are connected in sequence via refrigerant piping 611. To improve the heat exchange capacity of the first heat exchanger 613 and the second heat exchanger 615, a first fan 616 and a second fan 617 are also provided, respectively.

[0326] Figures 20 to 37 A reagent storage device 1 according to another embodiment of the present disclosure is shown. Figures 20 to 37 The reagent storage device 1 shown in another embodiment of this disclosure employs a reagent compartment 10, a reagent kit storage unit 20, a reagent kit 30, a puncture unit 40, and a heat preservation unit 60 that are similar to those used in other reagent storage devices. Figures 1 to 19 The same structure is shown in the embodiment; the composition, structure, and function of these parts can all be referred to. Figures 1 to 19 The embodiments shown below are only for reference. Figure 20 and Figure 37 The illustrated embodiments and Figures 1 to 19 The differences between the illustrated embodiments will be explained.

[0327] like Figures 20 to 37 As shown, the reagent storage device 1 in this embodiment does not include a base plate, and the structure of the puncture drive unit 50 is similar to... Figures 1 to 19 The reagent storage device 1 in the illustrated embodiment differs from the puncture drive unit 50 in that it is additionally equipped with a detection unit 80.

[0328] In this embodiment, each puncture drive unit 50 includes a switching part 51, a linkage part 52, an actuation part 56, a support part 57, and a movable connection part 58.

[0329] In this embodiment, each puncture driving unit 50 includes two switching parts 51 corresponding one-to-one with the two puncture units 40. Each switching part 51 is driven connected or driven to cooperate with the corresponding puncture unit 40 and is configured to drive the puncture unit 40 to switch between a first puncture working state and a second puncture working state. The two switching parts 51 are linked together by a linkage part 52 to simultaneously drive the two puncture units 40 corresponding to the same reagent kit accommodating space 20A to operate, so that the two puncture units 40 synchronously switch from the first puncture working state to the second puncture working state or from the second puncture working state to the first puncture working state.

[0330] In this embodiment, multiple sampling needles 41 of each puncture unit 42 are mounted on the sampling needle mounting part 42. The switching part 51 is driven to connect or drive to cooperate with the sampling needle mounting part 42 of the puncture unit 40 to drive the multiple sampling needles 41 to move synchronously.

[0331] The switching unit 51 includes a sampling needle drive mechanism 511 and a sampling needle reset mechanism 512. The sampling needle drive mechanism 511 applies a force to the puncture unit 40 to switch it from a first puncture working state to a second puncture working state. The sampling needle reset mechanism 512 applies a force to the puncture unit 40 to switch it from the second puncture working state to the first puncture working state.

[0332] The sample dispensing needle driving mechanism 511 includes a first movable part 5111 and a second movable part 5112. The first movable part 5111 has a first driving working position and a second driving working position. The second movable part 5112 is driven connected or driven to cooperate with the first movable part 5111 and the puncture unit 40. When the first movable part 5111 is in its first driving working position, the puncture unit 40 is in its first puncture working state; when the first movable part 5111 is in its second driving working position, the puncture unit 40 is in its second puncture working state.

[0333] like Figure 23-30 , Figure 32-37 As shown, the first movable part 5111 includes a first rotating component 51112, which is rotatably configured relative to the chamber body 11; the second movable part 5112 includes a second rotating component 51122, which is rotatably configured relative to the chamber body 11 and is drivenly connected to or driven to cooperate with the first rotating component 51112. The second rotating component 51122 drives the puncture unit 40 to switch between a first puncture working state and a second puncture working state.

[0334] In this embodiment, the first rotating component 51112 is a rotating shaft; the second rotating component 51122 includes a cam disposed on the rotating shaft, and the cam abuts against the puncture unit 40. The cam is directly fixedly connected to the rotating shaft. In this embodiment, the rotating shaft and the cam on it are both located outside the sample needle mounting portion 42 of the corresponding puncture unit 40. By changing the rotation angle of the cam relative to the sample needle mounting portion 42 when the rotating shaft and the cam rotate, the cam drives the sample needle mounting portion 42 to move closer to or away from the reagent kit accommodating space 20A, thereby switching the puncture unit 40 between the first puncture working state and the second puncture working state. The first movable part 5111, that is, the first driving working position of the rotating shaft, corresponds to the position where the long axis of the cam abuts against the sample needle mounting portion 42, and the second driving working position of the first movable part 5111, that is, the rotating shaft, corresponds to the position where the short axis of the cam abuts against the sample needle mounting portion 42.

[0335] like Figures 20 to 37In the illustrated embodiment, the sampling needle drive mechanism 511 is configured to apply a force to the puncture unit 40 to switch it from a second puncture working state to a first puncture working state. The sampling needle reset mechanism 512 is configured to apply a force to the puncture unit 40 to switch it from a first puncture working state to a second puncture working state.

[0336] Each needle reset mechanism 512 includes four springs 5121, which are located at the four corners of the reagent kit storage unit 20. Each spring 5121 has its two ends connected to the needle mounting portion 42 and the crossbeam 571. Each spring 5121 is a tension spring, thereby applying a force to the needle mounting portion 42 to move it away from the reagent kit storage unit 20. That is, the needle reset mechanism 512 is configured to apply a force to the puncture unit 40 to switch it from a first puncture working state to a second puncture working state.

[0337] like Figure 23-24 , Figure 26-29 , Figure 32-37 As shown, the linkage 52 is driven to connect or cooperate with the two switching parts 51 to make the puncture units 40 corresponding to the at least two switching parts 51 move synchronously. The linkage 52 includes a first rotating component 51112 connected to the two switching parts 51, that is, a belt drive mechanism 522 between the rotating shafts.

[0338] The belt drive mechanism 522 includes pulleys 5221 and 5222 respectively connected to two rotating shafts, and a conveyor belt 5223 mounted on pulleys 5221 and 5222. Through the belt drive mechanism 522, the two rotating shafts of the same puncture drive unit 50 rotate synchronously in opposite directions, thereby driving the two cams to rotate synchronously in opposite directions, which in turn drives the sample needle mounting part 42 to move synchronously in opposite directions, so that the upper and lower puncture units 40 can switch synchronously from the first puncture working state to the second puncture working state or from the second puncture working state to the first puncture working state.

[0339] exist Figures 20 to 37 In the illustrated embodiment, the actuation unit 56 includes a rotating handle 562, which is fixedly connected to a rotating shaft. The rotating handle 562 is located on the side of the chamber 11 where the chamber door 12 is located, i.e., the front side. Rotating the rotating handle 562 drives the rotating shaft to rotate, thereby causing the cam to rotate and switching the puncture unit 40 between a first puncture working state and a second puncture working state.

[0340] The support section 57 is used to install the switching section 51 and the linkage section 52. The support section 57 includes crossbeams 571 respectively disposed on the front and rear sides of each of the upper and lower sides of the compartment body 11, a connecting beam 572 connecting the front and rear crossbeams 571, a longitudinal beam 573 connecting the upper and lower crossbeams 571 on the rear side, two bearings 574 located in the bearing holes at the upper and lower ends of the longitudinal beam 573, and each of the two upper and lower rotating shafts passing through the front and rear crossbeams 571 and rotatably supported on the two crossbeams 571. The two ends of the rotating shaft pass through the corresponding crossbeams 571, the rear end of the rotating shaft passes through the corresponding bearing 574 and is connected to the pulley 5221 or 5222, and the front end of the rotating shaft is connected to the actuation section 56. The crossbeams 571, the connecting beams 572 and the longitudinal beams 573 are all fixed to the reagent kit storage unit 20.

[0341] The movable connecting part 58 is connected to both the cam and the puncture unit 40, and is configured to transmit the motion of the cam to the puncture unit 40 so that the rotation of the cam drives the puncture unit 40 to operate. Figures 29-30 As shown, the movable connecting part 58 includes a movable element 581, a first pin 582, and a second pin 583. The first pin 582 is disposed on the end face of the cam. The second pin 583 is disposed on the piercing unit 40 at a distance parallel to the first pin 582. The movable element 581 has an arc-shaped groove 581A. The movable element 581 is mounted on the cam and the piercing unit 40 through the first pin 582 and the second pin 583 engaging with the arc-shaped groove 581A. The first pin 582 and the second pin 583 are in sliding engagement with the arc-shaped groove 581A.

[0342] Figures 20 to 37 In the illustrated embodiment, the components of the reagent storage device 1 located inside the reagent compartment 10, such as the reagent storage unit 20, the puncture unit 40, and the puncture drive unit 50, are all installed on the bottom wall of the compartment 11 of the reagent compartment 10.

[0343] The detection unit 80 may include, for example, a reagent kit detection section 81 to determine whether the test kit 30 is properly installed within the reagent kit accommodating space 20A, and / or a door detection section 82 to determine whether the test compartment door 12 is tightly closed. The reagent kit detection section 81 and the door detection section 82 may be, for example, electromagnetic sensors, photoelectric sensors, etc.

[0344] The above embodiments are not intended to limit this disclosure. For example, although this disclosure... Figures 1 to 19 The illustrated embodiment does not include a detection unit 80; however, in variations of this embodiment, a detection unit 80 may be included. For example, although... Figures 20 to 37 The puncture drive unit 50 of the illustrated embodiment does not include a limiting part, a guide part, and a positioning part, but in some variations of this embodiment, at least one of the limiting part, the guide part, and the positioning part may still be provided.

[0345] Figure 38 A reagent operating system according to an embodiment of this disclosure is shown. For example... Figure 38 As shown, the reagent operating system provided in this embodiment includes the reagent storage device 1 described in the foregoing embodiments of this disclosure. The reagent operating system further includes a reagent receiving unit 2, a cleaning solution delivery unit 3, and a gas communication unit 4. The reagent receiving unit 2 is in communication with the internal channel 41A of the sample dispensing needle 41 of the puncture unit 40 located below the reagent kit containing space 20A. The gas communication unit 4 and the cleaning solution delivery unit 3 are respectively in communication with the internal channel 41A of the sample dispensing needle 41 of the puncture unit 40 located above the reagent kit containing space 20A. The reagent receiving unit 2 and the corresponding sample dispensing needle 41 are connected by a connecting tube passing through and sealing the compartment 11. The gas communication unit 4 and the cleaning solution delivery unit 3 are connected to the corresponding sample dispensing needle 41 by connecting tubes passing through and sealing the compartment 11.

[0346] The reagent operating system may include a controller. The controller is used to operate the reagent operating system. The controller may be coupled to, for example, the reagent receiving unit 2, the cleaning fluid delivery unit 3, and / or the gas communication unit 4. If the reagent storage device 1 includes a detection unit 80 and / or an actuator, the controller may also be coupled to the detection unit 80 and / or the actuator to receive detection signals from the detection unit 80 and / or issue control commands to the actuator. The controller may be implemented as a general-purpose processor, a programmable logic controller (PLC), a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field-programmable gate array (FPGA), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, or any suitable combination thereof for performing the functions described in this disclosure.

[0347] The operating procedure for this reagent operating system is explained below:

[0348] Open the compartment door 12, pull out the handle 561 to the foremost position or rotate the handle 562 to position the puncture unit 40 in the second puncture working position. If there is a used reagent kit 30 inside, remove it and place the reagent kit 30 into the reagent storage space 20A, ensuring it is properly installed. Push the handle 561 or rotate the handle to switch the puncture unit 40 from the second puncture working position to the first puncture working position, forcing the sample needle mounting parts 42 and the sample needles 41 of both the upper and lower puncture units 40 to move simultaneously toward the reagent storage space 20A. Each reagent needle 41 pierces the corresponding weak part 301 on the reagent kit 30, making the sample needle hole 41B communicate with the corresponding reagent storage space 30A. Close the compartment door 12.

[0349] Once reagent kit 30 is installed and door 12 is closed, the testing process is initiated. The reagent operating system completes the relevant tests, including controlling the connection and disconnection between reagent receiving unit 2 and / or gas communication unit 4 and reagent storage space 30A. If a controller is used, the relevant tests can be completed under its control. If a monitoring unit is connected to the controller, the position of reagent kit 30 and door 12 can be monitored through the monitoring unit and the controller.

[0350] After the test is completed, the cleaning solution delivery unit 3 supplies cleaning solution to the corresponding reagent storage space 30A. The corresponding end of the sampling needle 41 at the bottom of the reagent storage space 30A is immersed in the cleaning solution, which can be drained through an external device. By repeatedly using different cleaning solutions, the sampling needle 41 can be cleaned to the required level of cleanliness.

[0351] Open the compartment door 12, pull the handle 561 to the front or turn the rotary handle 562 to switch the puncture unit 40 to the second puncture working state, disconnect the sample needle 41 from the corresponding reagent storage space 30A, and then pull out the reagent kit 30 to complete the test cleaning process.

[0352] In this reagent operating system, the reagent receiving unit 2 can introduce the reagents in the reagent kit 30 into the reagent receiving unit 2 to realize reagent transfer; the gas communication unit 4 can introduce gas into the reagent storage space 30A of the reagent kit 30 during reagent transfer, thereby facilitating the control of the pressure of the reagent storage space 30A and the control of the reagent outflow rate; the cleaning solution delivery unit 3 can introduce cleaning solution into the reagent kit 30 after reagent transfer to clean the sample needle 41 that has come into contact with the reagent, thereby realizing the cleaning of the sample needle 41.

[0353] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them; although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications can still be made to the specific implementation of the present invention or equivalent substitutions can be made to some technical features without departing from the spirit of the technical solutions of the present invention, and all such modifications and substitutions should be covered within the scope of the technical solutions claimed in the present invention.

Claims

1. A reagent storage device (1), comprising: The reagent compartment (10) includes internal storage space; A reagent kit storage unit (20), disposed within the internal accommodating space, includes a reagent kit accommodating space (20A), the reagent kit accommodating space (20A) being configured to hold a reagent kit (30) having a reagent storage space (30A); and Multiple puncture units (40) are provided, each puncture unit (40) including a sample dispensing needle (41), the sample dispensing needle (41) having an internal channel (41A) and a puncture end (41C), the puncture end (41C) having a sample dispensing needle hole (41B) communicating with the internal channel (41A), the puncture unit (40) being movably disposed relative to the reagent storage unit (20) and having a first puncture working state and a second puncture working state, the puncture unit (40) being configured such that: when the reagent kit (30) is placed in the reagent accommodating space (20A), in the first puncture working state, the sample dispensing needle hole (41B) is communicating with the reagent storage space (30A) of the reagent kit (30), and in the second puncture working state, the sample dispensing needle hole (41B) is disconnected from the reagent storage space (30A) of the reagent kit (30); and The puncture drive unit (50) includes a switching part (51) that is driven connected to or driven to cooperate with the puncture unit (40), the switching part (51) being configured to drive the puncture unit (40) to switch between a first puncture working state and a second puncture working state; The reagent storage device (1) includes two or more puncture units (40) corresponding to the same reagent kit accommodating space (20A). In two or more puncture units (40) corresponding to the same reagent kit accommodating space (20A), the puncture end (41C) of the sample dispensing needle (41) of at least one puncture unit (40) is located outside or below the bottom of the corresponding reagent kit accommodating space (20A). The sample dispensing needle (41) includes a sample dispensing needle tube (411) and a sample dispensing needle tip (412) connected to the sample dispensing needle tube (411) at the puncture end (41C). The sample dispensing needle tube (411) has at least one bent section (4112); and / or the sample dispensing needle tube (411) has at least one flexible section; and / or the sample dispensing needle tube (411) has at least one telescopic section. In two or more puncture units (40) provided corresponding to the same reagent kit accommodating space (20A), the puncture end (41C) of the sample dispensing needle (41) of at least one puncture unit (40) is located on the top outside or above the corresponding reagent kit accommodating space (20A). The puncture drive unit (50) includes two or more switching parts (51) that correspond one-to-one with two or more puncture units (40) in the same reagent kit accommodating space (20A), and the two or more switching parts (51) are linked together so that the corresponding two or more puncture units (40) can be synchronously switched from the first puncture working state to the second puncture working state or from the second puncture working state to the first puncture working state.

2. The reagent storage device (1) according to claim 1, wherein The reagent storage unit (20) includes a reagent protection part (21) disposed between the sample dispensing needle (41) and the reagent accommodating space (20A), and the reagent protection part (21) has a puncture end avoidance port (21A) for avoiding the puncture end (41C) of the sample dispensing needle (41).

3. The reagent storage device (1) according to claim 1 or 2, wherein The sampling needle (41) of at least part of the puncture unit (40) includes: The sample dispensing needle tube (411), the internal channel (41A) being located within the sample dispensing needle tube (411); and The tip (412) of the sampling needle is located at the puncture end (41C) of the sampling needle (41) and connected to one end of the sampling needle tube (411). The tip (412) of the sampling needle is a cone with a gradually decreasing cross-section from the sampling needle tube (411) toward the side away from the sampling needle tube (411). The needle hole (41B) of the sampling needle is located on the side wall of the sampling needle tube (411) near the tip (412).

4. The reagent storage device (1) according to any one of claims 1 to 3, wherein The sample dispensing needle tube (411) includes: The first straight section (4111) of the sample dispensing needle extends along the surface of the reagent chamber (10) wall; and The second straight section (4113) of the sample dispensing needle extends from one side of the wall surface of the reagent compartment (10) toward the reagent kit accommodating space (20A). One end of the second straight section (4113) of the sample dispensing needle is connected to one end of the first straight section (4111) of the sample dispensing needle through a bent section (4112) of the sample dispensing needle. The tip (412) of the sample dispensing needle is connected to the other end of the second straight section (4113) of the sample dispensing needle.

5. The reagent storage device (1) according to any one of claims 1 to 4, wherein The puncture unit (40) also includes a sampling needle mounting part (42), on which the sampling needle (41) is fixed.

6. The reagent storage device (1) according to any one of claims 1 to 5, wherein The puncture unit (40) includes a sample needle mounting part (42) and a plurality of sample needles (41). The plurality of sample needles (41) are mounted on the sample needle mounting part (42). The switching part (51) is driven to connect or drive to cooperate with the sample needle mounting part (42) of the puncture unit (40) to drive the plurality of sample needles (41) to move synchronously.

7. The reagent storage device (1) according to any one of claims 1 to 6, wherein, The switching unit (51) includes a sampling needle drive mechanism (511) configured to apply a force to the puncture unit (40) to switch it from the first puncture working state to the second puncture working state and / or apply a force to switch it from the second puncture working state to the first puncture working state.

8. The reagent storage device (1) according to claim 7, wherein The dispensing needle drive mechanism (511) includes: The first active part (5111) has a first drive working position and a second drive working position; The second movable part (5112) is driven connected or driven to cooperate with the first movable part (5111) and the puncture unit (40) to transmit the action of the first movable part (5111) to the puncture unit (40). When the first movable part (5111) is in the first driven working position, the puncture unit (40) is in one of the first puncture working state and the second puncture working state. When the first movable part (5111) is in the second driven working position, the puncture unit (40) is in the other of the first puncture working state and the second puncture working state.

9. The reagent storage device (1) according to claim 8, wherein The puncture drive unit (50) includes a linkage part (52), which is driven to be connected or driven to cooperate with at least two switching parts (51) so that the puncture units (40) corresponding to the at least two switching parts (51) move synchronously.

10. The reagent storage device (1) according to claim 8 or 9, wherein The puncture drive unit (50) includes: The limiting part (53) is configured to limit the range of motion of the first movable part (5111) and / or the second movable part (5112); and / or The guide (54) is configured to guide the movement of the first movable part (5111) and / or the second movable part (5112).

11. The reagent storage device (1) according to claim 10, wherein, The limiting portion (53) is configured to limit the range of motion of the linkage portion (52) of the puncture drive unit (50) to limit the range of motion of the first movable portion (5111) and / or the second movable portion (5112); and / or The guide portion (54) is configured to guide the movement of the linkage portion (52) of the puncture drive unit (50) to guide the movement of the first movable portion (5111) and / or the second movable portion (5112).

12. The reagent storage device (1) according to claim 10 or 11, wherein, The limiting part (53) includes one or more limiting structures, at least one of the limiting structures including a limiting groove (53A) and a limiting surface (53B), the limiting surface (53B) being movably located within the limiting groove (53A) and having an abutment state with the limiting groove (53A), one of the limiting groove (53A) and the limiting surface (53B) being fixed relative to one of the first movable part (5111) and the second movable part (5112), and the other being fixed relative to the other of the first movable part (5111) and the second movable part (5112); and / or The guide portion (54) includes one or more guide structures, at least one of which includes a guide groove (54A) and a guide surface (54B). The guide surface (54B) is slidably engaged with the guide groove (54A). One of the guide groove (54A) and the guide surface (54B) is fixed relative to the reagent compartment (10), and the other is fixed relative to the first movable portion (5111) or the second movable portion (5112).

13. The reagent storage device (1) according to any one of claims 8 to 12, wherein, The puncture drive unit (50) further includes a positioning part (55), which has a positioning state that keeps the puncture unit (40) in the first puncture working state and / or the second puncture working state and an avoidance state that prevents interference with the switching of the working position of the puncture unit (40). The positioning part (55) is movably arranged relative to the reagent compartment (10) to switch between the avoidance state and the positioning state.

14. The reagent storage device (1) according to claim 13, wherein, The positioning part (55) is driven to cooperate with the reagent kit (30) to switch between the avoidance state and the positioning state under the drive of the reagent kit (30).

15. The reagent storage device (1) according to claim 14, wherein The positioning part (55) includes a slider (551) and a slider reset mechanism (552). The slider (551) is movably installed in the internal accommodating space relative to the reagent compartment (10) and includes a positioning surface (5511D). The slider (551) is driven to cooperate with the reagent kit (30). In the avoidance state of the positioning part (55), the slider (551) is in an avoidance position where the positioning surface (5511D) is separated from the second movable part (5112), and the slider reset mechanism (552) is in a charging state. In the positioning state of the positioning part (55), the slider (551) is in a positioning position where the positioning surface (5511D) abuts against the second movable part (5112), and the slider reset mechanism (552) is in a releasing state.

16. The reagent storage device (1) according to any one of claims 8 to 15, wherein, The first movable part (5111) includes a first translation component (51111), which is reciprocally movable relative to the reagent chamber (10) along a first direction (X). The first translation component (51111) is provided with a driving surface (51111A), which is inclined along the first direction (X) toward a second direction (Z) perpendicular to the first direction (X). The second movable part (5112) includes a second translation component (51121). The second translation component (51121) is fixedly disposed relative to the sample dispensing needle (41) and reciprocally disposed relative to the reagent chamber (10) along the second direction (Z). The second translation component (51121) is provided with a mating surface (51121A) corresponding to the driving surface (51111A). The mating surface (51121A) is inclined towards the second direction (Z) along the first direction (X). By changing the position of the first translation component (51111) in the first direction (X), the mating position of the driving surface (51111A) and the mating surface (51121A) is changed, thereby changing the position of the second translation component (51121) along the second direction (Z).

17. The reagent storage device (1) according to claim 16, wherein The puncture drive unit (50) includes a linkage part (52), which is driven to connect with or cooperate with at least two switching parts (51) to make the puncture units (40) corresponding to the at least two switching parts (51) move synchronously. The linkage (52) includes a push-pull rod (521) extending along the first direction (X). The first translation component (51111) is fixed to the push-pull rod (521), and the driving surface (51111A) is disposed on the side of the push-pull rod (521) near the second translation component (51121); The second translation component (51121) includes a pressure plate arranged along the second direction (Z), and the mating surface (51121A) is disposed at the end of the pressure plate near the first translation component (51111).

18. The reagent storage device (1) according to claim 17, wherein, The puncture drive unit (50) includes a limiting part (53), which is configured to limit the range of motion of the linkage part (52) to limit the range of motion of the first movable part (5111). The limiting part (53) includes one or more limiting structures, at least one of which includes a limiting groove (53A) and a limiting surface (53B). The limiting surface (53B) is movably located within the limiting groove (53A) and has an abutment state with the limiting groove (53A). One of the limiting groove (53A) and the limiting surface (53B) is disposed on the second movable part (5112), and the other is disposed on the push-pull rod (521); and / or The puncture drive unit (50) includes a guide portion (54) configured to guide the movement of the linkage portion (52) to guide the movement of the first movable portion (5111). The guide portion (54) includes one or more guide structures, at least one of which includes a guide groove (54A) and a guide surface (54B). One of the guide groove (54A) and the guide surface (54B) is fixed relative to the reagent chamber (10), and the other is disposed on the push-pull rod (521).

19. The reagent storage device (1) according to any one of claims 8 to 14, wherein, The first movable part (5111) includes a first rotating component (51112), which is rotatably disposed relative to the reagent chamber (10); The second movable part (5112) includes a second rotating component (51122), which is rotatably disposed relative to the reagent chamber (10) and drivenly connected or driven to cooperate with the first rotating component (51112). The second rotating component (51122) drives the puncture unit (40) to switch between the first puncture working state and the second puncture working state.

20. The reagent storage device (1) according to claim 19, wherein, The first rotating component (51112) is a rotating shaft; The second rotating component (51122) includes a cam disposed on the rotating shaft, the cam being in a pressing engagement with the puncture unit (40).

21. The reagent storage device (1) according to claim 20, wherein The puncture drive unit (50) further includes a movable connection part (58), which is connected to the cam and the puncture unit (40) respectively, and is configured to transmit the motion of the cam to the puncture unit (40) so that the rotation of the cam drives the puncture unit (40) to move.

22. The reagent storage device (1) according to claim 21, wherein The movable connecting part (58) includes: The first pin (582) is disposed on the end face of the cam; The second pin (583) is disposed on the puncture unit (40) at a distance parallel to the first pin (582); The movable element (581) has an arc-shaped groove (581A). The movable element (581) is mounted on the cam and the puncture unit (40) through the first pin (582) and the second pin (583) cooperating with the arc-shaped groove (581A). The first pin (582) and the second pin (583) are in sliding engagement with the arc-shaped groove (581A).

23. The reagent storage device (1) according to any one of claims 19 to 22, wherein, The puncture drive unit (50) includes a linkage part (52), which is driven to be connected to or driven to cooperate with at least two switching parts (51) so that the puncture units (40) corresponding to the at least two switching parts (51) move synchronously; The linkage (52) includes at least one of the following: a belt drive mechanism (522), a chain drive mechanism, a gear drive mechanism, a gear and rack drive mechanism, or a linkage mechanism connected between the first rotating component (51112) of the at least two switching parts (51).

24. The reagent storage device (1) according to any one of claims 18 to 23, wherein The puncture drive unit (50) further includes an actuator (56), which is driven connected to or driven to cooperate with the first movable part (5111); the actuator (56) includes: A handle (561) or a rotary handle (562) is driven to connect or engage with the first movable part (5111); or The actuator is driven to connect or cooperate with the first active part (5111).

25. The reagent storage device (1) according to any one of claims 7 to 24, wherein, wherein, The switching unit (51) includes a sample dispensing needle reset mechanism (512), wherein, One of the sampling needle drive mechanism (511) and the sampling needle reset mechanism (512) is configured to apply a force to the puncture unit (40) to switch it from the first puncture working state to the second puncture working state; The other of the sampling needle drive mechanism (511) and the sampling needle reset mechanism (512) is configured to apply a force to the puncture unit (40) to switch it from the second puncture working state to the first puncture working state.

26. The reagent storage device (1) according to claim 25, wherein The sample dispensing needle reset mechanism (512) includes at least one spring (5121); wherein, The spring (5121) is located and / or connected between the puncture unit (40) and the reagent storage unit (20); or The spring (5121) is located and / or connected between the puncture unit (40) and the reagent chamber (10).

27. The reagent storage device (1) according to any one of claims 1 to 26, wherein The reagent storage device (1) includes a plurality of the reagent kit storage units (20), and / or the reagent kit storage units (20) include a plurality of the reagent kit accommodating spaces (20A).

28. The reagent storage device (1) according to any one of claims 1 to 27, wherein The reagent storage device (1) further includes a heat preservation unit (60) configured to maintain the temperature of the reagent compartment (10).

29. The reagent storage device (1) according to claim 28, wherein The insulation unit (60) includes a refrigerant circulation system (61) configured to regulate the temperature inside the reagent chamber (10).

30. The reagent storage device (1) according to any one of claims 1 to 29, wherein, The reagent storage device (1) includes a reagent kit (30), the reagent kit (30) includes a reagent storage space (30A), and the reagent kit accommodating space (20A) of the reagent storage device (1) is used to place the reagent kit (30). In the first puncture working state of the puncture unit (40), the sample dispensing needle orifice (41B) is connected to the reagent storage space (30A) of the reagent kit (30) placed in the reagent kit accommodating space (20A). In the second puncture working state of the puncture unit (40), the sample dispensing needle orifice (41B) is disconnected from the reagent storage space (30A) of the reagent kit (30) placed in the reagent kit accommodating space (20A).

31. The reagent storage device (1) according to claim 30, wherein The reagent kit (30) has a weak part (301) corresponding to the puncture end (41C) of the sample dispensing needle (41). In the first puncture working state of the puncture unit (40), the puncture end (41C) of the sample dispensing needle (41) enters the reagent storage space (30A) by puncturing the weak part (301), thereby realizing the connection between the sample dispensing needle hole (41B) of the sample dispensing needle (41) and the reagent storage space (30A) of the reagent kit (30).

32. The reagent storage device (1) according to any one of claims 1 to 31, wherein At least one of the puncture units (40) is located within the internal accommodating space.

33. The reagent storage device (1) according to any one of claims 1 to 32, wherein It also includes a base plate (70) located within the internal accommodating space and mounted on the bottom wall of the reagent compartment (10), and the reagent storage unit (20) and / or the puncture unit (40) mounted on the base plate (70).

34. A reagent operating system, comprising a reagent storage device (1) according to any one of claims 1 to 33; wherein the reagent operating system further comprises: The reagent receiving part (2) is in communication with the internal channel (41A) of the sample dispensing needle (41) of at least one of the puncture units (40); and / or The cleaning fluid delivery unit (3) is in communication with the internal channel (41A) of the sample dispensing needle (41) of at least one of the puncture units (40); and / or The gas communication section (4) is in communication with the internal channel (41A) of the sample dispensing needle (41) of at least one of the puncture units (40).

35. The reagent operating system according to claim 34, wherein, The reagent operating system includes the reagent receiving unit (2) and the cleaning solution delivery unit (3), wherein the reagent receiving unit (2) and the cleaning solution delivery unit (3) are respectively connected to the internal channels (41A) of the sample dispensing needles (41) of different puncture units (40); and / or The reagent operating system includes the cleaning fluid delivery unit (3) and the gas communication unit (4). The cleaning fluid delivery unit (3) and the gas communication unit (4) are in communication with the internal channel (41A) of the sample dispensing needle (41) of the same puncture unit (40) at different times.

36. The reagent handling system of claim 34 or 35, wherein, The reagent operating system includes the reagent receiving unit (2) and the cleaning solution delivery unit (3), wherein, The puncture end (41C) of the sample dispensing needle (41) of the puncture unit (40) which is in communication with the reagent receiving part (2) is located on the bottom outside or below the corresponding reagent kit accommodating space (20A); The puncture end (41C) of the sample dispensing needle (41) of the puncture unit (40) which is in communication with the cleaning solution delivery unit (3) is located on the top outside or above the corresponding reagent kit accommodating space (20A).

37. The reagent operating system according to any one of claims 34 to 36, wherein, The reagent receiving unit (2) is connected to the sample dispensing needle (41) of at least one of the puncture units (40) via a connecting tube having a flexible section or a telescopic section; and / or The cleaning fluid delivery unit (3) is connected to the sampling needle (41) of at least one of the puncture units (40) via a connecting tube having a flexible section or a telescopic section; and / or The gas communication section (4) is connected to the sample application needle (41) of at least one of the puncture units (40) via a connecting tube having a flexible section or a telescopic section.

38. The reagent operating system according to any one of claims 34 to 37, wherein, The reagent receiving part (2) is connected to the sample dispensing needle (41) of at least one of the puncture units (40) via a connecting tube that passes through the reagent chamber (10) and is sealed to the reagent chamber (10); and / or The cleaning fluid delivery unit (3) is connected to the sample dispensing needle (41) of at least one of the puncture units (40) via a connecting tube that passes through the reagent chamber (10) and is sealed to the reagent chamber (10); and / or The gas communication section (4) is connected to the sample application needle (41) of at least one of the puncture units (40) by a connecting tube that passes through the reagent chamber (10) and is sealed between the reagent chamber (10).

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