Manufacturing method of high-simulation nerve

Abstract

The invention discloses a manufacturing method of a high-simulation nerve, and belongs to the technical field of human body medicine and animal teaching models, and the manufacturing method comprises the following steps: manufacturing a mold by overturning the mold, manufacturing a gel coat, closing the mold, pouring, opening the mold and trimming. According to the method, a real specimen is directly used as a model seed for model turning and copying, so that the problem of form distortion is avoided; materials used for injection molding are silicon rubber and white glass fibers or polypropylene fibers, the texture of the silicon rubber is similar to the hardness of a real specimen, and the fibers are arranged in longitudinal rows and embedded in the silicon rubber and are very similar to a real specimen in the aspect of anatomical observation; according to the invention, a real object specimen can be copied in form, and the texture and tissue structure are close to those of the real object specimen.

Description

Technical Field

[0001] The present invention relates to the technical field of human medicine and animal teaching models, and in particular to a method for making a highly simulated nerve. Background Art

[0002] In human and veterinary medical education, neural models are important teaching tools to help students understand the complex structure and function of the nervous system. These models can be physical and three-dimensional, or virtual and digital. Physical neural models are usually made to scale with the structure of the nervous system, including the brain, spinal cord, nerve fibers, and ganglia. These models often adopt a detachable design to facilitate students to observe the structure and relationship between the various parts of the nervous system. It can provide an intuitive learning experience, and students can understand the physical structure of the nervous system through touch and observation. It is easy to operate and observe in detail, especially for the understanding of spatial structure.

[0003] However, most of the existing human medical and animal teaching models are sculpted based on real specimens or atlases, and then the models are reproduced. This method often has morphological distortion problems when sculpting the models; one of the materials such as gypsum, resin, PVC, etc. is often used as the injection molding material during injection molding. These materials are relatively hard, while the real specimens are relatively soft compared to them; the peripheral nerves in the real specimens are mainly composed of fibers arranged in longitudinal rows, and the course of the fiber bundles can be seen by anatomical observation, while the existing models only carve out textures similar to their course on the surface, which is too distorted compared to the real specimens. In addition, the production cost is high, and it is not easy to use on a large scale; the update iteration is slow, and it is difficult to reflect the latest scientific research results in a timely manner. Summary of the invention

[0004] In view of this, the present invention provides a method for producing a highly simulated nerve to solve the problem that the existing nerves in human medicine and animal teaching models are distorted in terms of morphology, texture, and tissue structure.

[0005] In order to solve the above technical problems, the technical solution of the present invention is: A method for manufacturing a highly simulated nerve comprises the following steps: mold making, film injection, mold closing, mold opening and trimming; The film turning mold making method comprises the following steps: (1) Select a human or animal specimen containing nerves after dissection and place it on a plate larger than the specimen, with the long axis of the specimen parallel to the plate; (2) Fill the lower half of the specimen with plasticine until it reaches the level of the specimen's midline. The filled midline level should be 5 cm greater than the specimen's edge. (3) Apply a thin layer of vaseline on the surface of the specimen not covered by the plasticine and on the horizontal surface of the plasticine; (4) Weigh the liquid silicone rubber and add silicone rubber curing agent into it. The ratio of silicone rubber curing agent to silicone rubber is 1:15-25; put the prepared liquid silicone rubber into a vacuum chamber and evacuate it; (5) Apply liquid silicone rubber to the horizontal surface of the specimen and the plasticine; (6) After the liquid silicone rubber solidifies, cover its surface with gauze; (7) Repeat step (4); (8) Apply liquid silicone rubber on gauze; after the liquid silicone rubber solidifies, apply a thin layer of vaseline on its surface; (9) Prepare FRP resin: Take epoxy resin and add epoxy resin curing agent; (10) Apply the prepared FRP resin to the surface of the cured silicone rubber coat. When the FRP resin has been formed but not completely cured, cover the surface with FRP cloth; (11) Repeat step (9); (12) Apply the prepared FRP resin to the surface of the FRP cloth and leave it for 10-14 hours to allow it to fully cure; (13) After the FRP resin is completely cured, half of the mold is completed; (14) Turn over the mold halves, the specimen, the plasticine, and the flat plate underneath so that the flat plate is at the top instead of the bottom. Remove the flat plate and the plasticine to expose the specimen. (15) Making the other half of the mold, the making method and steps are the same as steps (3) to (13); (16) After the FRP resin is completely cured, separate the upper and lower parts of the mold and take out the specimen; (17) Use an electric drill to drill a hole at the mold joint. This hole will serve as the pouring port. Use scissors and an angle grinder to trim the mold. The mold is now complete.

[0006] Wherein, the physical specimen is an immersion specimen or a plasticized specimen.

[0007] Wherein, in the step (4), the vacuum degree of the vacuum pumping is between -0.08 and -0.1 MPa, and the time is between 30 and 60 seconds.

[0008] Wherein, the epoxy resin curing agent is Wherein, the film injection comprises the following steps: (1) Use a brush to apply a thin layer of vaseline as a release agent on the inner surface of the mold; (2) Use scissors to cut the fibers into corresponding lengths according to the length of the peripheral nerve on the specimen; (3) Take liquid silicone rubber and add silicone rubber curing agent, the ratio of silicone rubber curing agent to silicone rubber is 1:20-30; (4) Immerse the spare fiber in the prepared liquid silicone rubber and place the two together in a vacuum chamber to evacuate the vacuum; (5) The impregnated fibers are placed at the corresponding positions on the inner surface of the mold according to the nerve path in the specimen to complete the injection molding; Wherein, the fiber is glass fiber or flax fiber.

[0009] Wherein, in the step (4), the vacuum degree of the vacuum pumping is between -0.08 and -0.1 MPa, and the time is 30-60 seconds.

[0010] Among them, the mold closing step is specifically as follows: after the paving is completed, the molds are closed together to complete the mold closing.

[0011] The specific mold opening steps are as follows: after mold closing, place the mold for 12-20 hours to wait for the liquid silicone rubber to solidify; after solidification, open the mold and take out the model.

[0012] Among them, the finishing steps are specifically as follows: trimming the mold marks with scissors.

[0013] Compared with the prior art, the technical solution provided by the present invention has the following beneficial effects: (1) The present invention directly uses the real specimen as a mold for replication, thus avoiding the problem of morphological distortion; the materials used for injection molding are silicone rubber and flax fiber or glass fiber. The texture of silicone rubber is similar to the hardness of the real specimen. The flax fiber or glass fiber is arranged in longitudinal rows and embedded in the silicone rubber, which is very similar to the real specimen in terms of anatomical observation.

[0014] (2) Compared with the real specimens, the model produced by the present invention has the advantages of being easy to preserve, non-toxic, tasteless, low cost, and no restrictions on the raw materials required for production, which is conducive to the popularization of the product and more convenient for school teachers and students to use. Compared with ordinary models, it is closer to the real specimen in terms of morphological structure, texture hardness, tissue composition, etc., avoiding the disadvantages of ordinary models being distorted, so that students will not suffer cognitive bias due to the distortion of the reference model when learning relevant knowledge, which is more conducive to the teaching of human medicine and animal related knowledge. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a picture of the highly simulated neural product obtained in Example 1. DETAILED DESCRIPTION

[0016] The following embodiments are provided for a better understanding of the present invention, but are not limited to the best mode of implementation, and do not limit the content and protection scope of the present invention. Any product identical or similar to the present invention obtained under the inspiration of the present invention or by combining the features of the present invention with other prior arts shall fall within the protection scope of the present invention.

[0017] In the following examples, the silicone rubber curing agent was purchased from Hangzhou Jessica Chemical Co., Ltd. with a brand name of ND22; the epoxy resin curing agent was purchased from Jinan Chenghao Chemical Co., Ltd. with a brand name of T31. Example 1

[0018] This embodiment provides a method for manufacturing a highly simulated nerve, including the following steps: mold making, film injection, mold closing, mold opening and trimming; The film turning mold making method comprises the following steps: (1) Select a human or animal specimen containing nerve plastination after dissection and place it on a plate larger than the specimen, with the long axis of the specimen parallel to the plate surface; (2) Fill the lower half of the specimen with plasticine until it reaches the level of the specimen's midline. The filled midline level should be 5 cm greater than the specimen's edge. (3) Apply a thin layer of vaseline on the surface of the specimen not covered by the plasticine and on the horizontal surface of the plasticine; (4) Weigh the liquid silicone rubber and add silicone rubber curing agent into it, the ratio of silicone rubber curing agent to silicone rubber is 1:20; put the prepared liquid silicone rubber into a vacuum chamber and evacuate the vacuum; the vacuum degree of evacuation is -0.09MPa, and the time is 45s; (5) Apply liquid silicone rubber to the horizontal surface of the specimen and the plasticine; (6) After the liquid silicone rubber solidifies, cover its surface with gauze; (7) Repeat step (4); (8) Apply liquid silicone rubber on gauze; after the liquid silicone rubber solidifies, apply a thin layer of vaseline on its surface; (9) Prepare FRP resin: Take epoxy resin and add epoxy resin curing agent; (10) Apply the prepared FRP resin to the surface of the cured silicone rubber coat. When the FRP resin has been formed but not completely cured, cover the surface with FRP cloth; (11) Repeat step (9); (12) Apply the prepared FRP resin on the surface of the FRP cloth and leave it for 12 hours to allow it to completely cure; (13) After the FRP resin is completely cured, half of the mold is completed; (14) Turn over the mold halves, the specimen, the plasticine, and the flat plate underneath so that the flat plate is at the top instead of the bottom. Remove the flat plate and the plasticine to expose the specimen. (15) Making the other half of the mold, the making method and steps are the same as steps (3) to (13); (16) After the FRP resin is completely cured, separate the upper and lower parts of the mold and take out the specimen; (17) Use an electric drill to drill a hole at the mold joint. This hole will serve as the pouring port. Use scissors and an angle grinder to trim the mold. The mold is now complete.

[0019] Wherein, the film injection comprises the following steps: (1) Use a brush to apply a thin layer of vaseline as a release agent on the inner surface of the mold; (2) Use scissors to cut the glass fiber into the corresponding length according to the length of the peripheral nerve on the specimen; (3) Take liquid silicone rubber and add silicone rubber curing agent, the ratio of silicone rubber curing agent to silicone rubber is 1:25; (4) Immerse the spare fiber in the prepared liquid silicone rubber, and put the two together into a vacuum chamber for evacuation; the vacuum degree of evacuation is -0.09 MPa, and the time is 45 seconds; (5) The impregnated fibers are placed at the corresponding positions on the inner surface of the mold according to the nerve path in the specimen to complete the injection molding; Among them, the mold closing step is specifically as follows: after the paving is completed, the molds are closed together to complete the mold closing.

[0020] The specific mold opening steps are as follows: after the mold is closed, place it for 16 hours to wait for the liquid silicone rubber to solidify; after the solidification is completed, open the mold and take out the model.

[0021] Among them, the finishing steps are specifically as follows: trimming the mold marks with scissors.

[0022] The high-simulation neural product obtained in this embodiment is shown in FIG. Figure 1 As shown, the nerve is the yellow part in the figure. Example 2

[0023] This embodiment provides a method for manufacturing a highly simulated nerve, including the following steps: mold making, mold injection, mold closing, mold opening and trimming; The film turning mold making method comprises the following steps: (1) Select a human or animal specimen containing nerve plastination after dissection and place it on a plate larger than the specimen, with the long axis of the specimen parallel to the plate surface; (2) Fill the lower half of the specimen with plasticine until it reaches the level of the specimen's midline. The filled midline level should be 5 cm greater than the specimen's edge. (3) Apply a thin layer of vaseline on the surface of the specimen not covered by the plasticine and on the horizontal surface of the plasticine; (4) Weigh the liquid silicone rubber and add silicone rubber curing agent into it, the ratio of silicone rubber curing agent to silicone rubber is 1:15; put the prepared liquid silicone rubber into a vacuum chamber and evacuate it; the vacuum degree of evacuation is -0.1MPa, and the time is 30s; (5) Apply liquid silicone rubber to the horizontal surface of the specimen and the plasticine; (6) After the liquid silicone rubber solidifies, cover its surface with gauze; (7) Repeat step (4); (8) Apply liquid silicone rubber on gauze; after the liquid silicone rubber solidifies, apply a thin layer of vaseline on its surface; (9) Prepare FRP resin: Take epoxy resin and add epoxy resin curing agent; (10) Apply the prepared FRP resin to the surface of the cured silicone rubber coat. When the FRP resin has been formed but not completely cured, cover the surface with FRP cloth; (11) Repeat step (9); (12) Apply the prepared FRP resin on the surface of the FRP cloth and leave it for 10 hours to allow it to completely cure; (13) After the FRP resin is completely cured, half of the mold is completed; (14) Turn over the mold halves, the specimen, the plasticine, and the flat plate underneath so that the flat plate is at the top instead of the bottom. Remove the flat plate and the plasticine to expose the specimen. (15) Making the other half of the mold, the making method and steps are the same as steps (3) to (13); (16) After the FRP resin is completely cured, separate the upper and lower parts of the mold and take out the specimen; (17) Use an electric drill to drill a hole at the mold joint. This hole will serve as the pouring port. Use scissors and an angle grinder to trim the mold. The mold is now complete.

[0024] Wherein, the film injection comprises the following steps: (1) Use a brush to apply a thin layer of vaseline as a release agent on the inner surface of the mold; (2) Use scissors to cut the flax fibers into corresponding lengths according to the length of the peripheral nerves on the specimen; (3) Take liquid silicone rubber and add silicone rubber curing agent, the ratio of silicone rubber curing agent to silicone rubber is 1:20; (4) Immerse the spare fiber in the prepared liquid silicone rubber and put the two together into a vacuum chamber for evacuation; the vacuum degree of evacuation is -0.08 MPa and the time is 60 seconds; (5) The impregnated fibers are placed at the corresponding positions on the inner surface of the mold according to the nerve path in the specimen to complete the injection molding; Among them, the mold closing step is specifically as follows: after the paving is completed, the molds are closed together to complete the mold closing.

[0025] The specific mold opening steps are as follows: after the mold is closed, place it for 12 hours to wait for the liquid silicone rubber to solidify; after the solidification is completed, open the mold and take out the model.

[0026] Among them, the finishing steps are specifically as follows: trimming the mold marks with scissors. Example 3

[0027] This embodiment provides a method for manufacturing a highly simulated nerve, including the following steps: mold making, mold injection, mold closing, mold opening and trimming; The film turning mold making method comprises the following steps: (1) Select a human or animal specimen containing nerves that has been dissected and place it on a plate that is larger than the specimen, with the long axis of the specimen parallel to the plate surface; (2) Fill the lower half of the specimen with plasticine until it reaches the level of the specimen's midline. The filled midline level should be 5 cm greater than the specimen's edge. (3) Apply a thin layer of vaseline on the surface of the specimen not covered by the plasticine and on the horizontal surface of the plasticine; (4) Weigh the liquid silicone rubber and add silicone rubber curing agent into it, the ratio of silicone rubber curing agent to silicone rubber is 1:25; put the prepared liquid silicone rubber into a vacuum chamber and evacuate the vacuum; the vacuum degree of evacuation is -0.08 MPa, and the time is 60 seconds; (5) Apply liquid silicone rubber to the horizontal surface of the specimen and the plasticine; (6) After the liquid silicone rubber solidifies, cover its surface with gauze; (7) Repeat step (4); (8) Apply liquid silicone rubber on gauze; after the liquid silicone rubber solidifies, apply a thin layer of vaseline on its surface; (9) Prepare FRP resin: Take epoxy resin and add epoxy resin curing agent; (10) Apply the prepared FRP resin to the surface of the cured silicone rubber coat. When the FRP resin has been formed but not completely cured, cover the surface with FRP cloth; (11) Repeat step (9); (12) Apply the prepared FRP resin to the surface of the FRP cloth and leave it for 14 hours to allow it to completely cure; (13) After the FRP resin is completely cured, half of the mold is completed; (14) Turn over the mold halves, the specimen, the plasticine, and the flat plate underneath so that the flat plate is at the top instead of the bottom. Remove the flat plate and the plasticine to expose the specimen. (15) Making the other half of the mold, the making method and steps are the same as steps (3) to (13); (16) After the FRP resin is completely cured, separate the upper and lower parts of the mold and take out the specimen; (17) Use an electric drill to drill a hole at the mold joint. This hole will serve as the pouring port. Use scissors and an angle grinder to trim the mold. The mold is now complete.

[0028] Wherein, the film injection comprises the following steps: (1) Use a brush to apply a thin layer of vaseline as a release agent on the inner surface of the mold; (2) Use scissors to cut the flax fibers into corresponding lengths according to the length of the peripheral nerves on the specimen; (3) Take liquid silicone rubber and add silicone rubber curing agent, the ratio of silicone rubber curing agent to silicone rubber is 1:30; (4) Immerse the spare fiber in the prepared liquid silicone rubber, and put the two together into a vacuum chamber for evacuation; the vacuum degree of evacuation is -0.1MPa, and the time is 30s; (5) The impregnated fibers are placed at the corresponding positions on the inner surface of the mold according to the nerve path in the specimen to complete the injection molding; Among them, the mold closing step is specifically as follows: after the paving is completed, the molds are closed together to complete the mold closing.

[0029] The specific mold opening steps are as follows: after mold closing, place the mold for 20 hours to wait for the liquid silicone rubber to solidify; after solidification, open the mold and take out the model.

[0030] Among them, the finishing steps are specifically as follows: trimming the mold marks with scissors.

[0031] Although the embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and cannot be understood as limiting the present invention. A person skilled in the art may change, modify, replace and modify the above embodiments within the scope of the present invention without departing from the principles and purpose of the present invention. The protection scope of the present invention is defined by the claims and their equivalent technical solutions.

Claims

1. A method for producing a highly simulated nerve, characterized in that The process includes the following steps: mold making, film injection, mold closing, mold opening and trimming; The film turning mold making method comprises the following steps: (1) Select a human or animal specimen containing nerves after dissection and place it on a plate larger than the specimen, with the long axis of the specimen parallel to the plate; (2) Fill the lower half of the specimen with plasticine until it reaches the level of the specimen's midline. The filled midline level should be 5 cm greater than the specimen's edge. (3) Apply a thin layer of vaseline on the surface of the specimen not covered by the plasticine and on the horizontal surface of the plasticine; (4) Weigh the liquid silicone rubber and add silicone rubber curing agent into it. The ratio of silicone rubber curing agent to silicone rubber is 1:15-25; put the prepared liquid silicone rubber into a vacuum chamber and evacuate it; (5) Apply liquid silicone rubber to the horizontal surface of the specimen and the plasticine; (6) After the liquid silicone rubber solidifies, cover its surface with gauze; (7) Repeat step (4); (8) Apply liquid silicone rubber on gauze; after the liquid silicone rubber solidifies, apply a thin layer of vaseline on its surface; (9) Prepare FRP resin: Take epoxy resin and add epoxy resin curing agent; (10) Apply the prepared FRP resin to the surface of the cured silicone rubber coat. When the FRP resin has been formed but not completely cured, cover the surface with FRP cloth; (11) Repeat step (9); (12) Apply the prepared FRP resin to the surface of the FRP cloth and leave it for 10-14 hours to allow it to fully cure; (13) After the FRP resin is completely cured, half of the mold is completed; (14) Turn over the mold halves, the specimen, the plasticine, and the flat plate underneath so that the flat plate is at the top instead of the bottom. Remove the flat plate and the plasticine to expose the specimen. (15) Making the other half of the mold, the making method and steps are the same as steps (3) to (13); (16) After the FRP resin is completely cured, separate the upper and lower parts of the mold and take out the specimen; (17) Use an electric drill to drill a hole at the mold joint. This hole will serve as the pouring port. Use scissors and an angle grinder to trim the mold. The mold is now complete.

2. The method for making a highly simulated nerve according to claim 1, characterized in that: The physical specimen is an immersion specimen or a plasticized specimen.

3. The method for making a highly simulated nerve according to claim 1, characterized in that: In the step (4), the vacuum degree of the vacuum pumping is between -0.08 and -0.1 MPa, and the time is 30-60 seconds.

4. The method for making a highly simulated nerve according to claim 1, characterized in that The injection molding comprises the following steps: (1) Use a brush to apply a thin layer of vaseline as a release agent on the inner surface of the mold; (2) Use scissors to cut the fibers into corresponding lengths according to the length of the peripheral nerve on the specimen; (3) Take liquid silicone rubber and add silicone rubber curing agent, the ratio of silicone rubber curing agent to silicone rubber is 1:20-30; (4) Immerse the spare fiber in the prepared liquid silicone rubber and place the two together in a vacuum chamber to evacuate the air; (5) The impregnated fibers are placed in the corresponding positions on the inner surface of the mold according to the nerve path in the specimen to complete the injection molding.

5. The method for making a highly simulated nerve according to claim 4, characterized in that: The fiber is glass fiber or flax fiber.

6. The method for making a highly simulated nerve according to claim 4, characterized in that: In the step (4), the vacuum degree of the vacuum pumping is between -0.08 and -0.1 MPa, and the time is 30-60 seconds.

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