Tripeptide-1 melanin biological agent, preparation method and application

Abstract

The invention relates to the technical field of hair nutritional agents, in particular to a tripeptide-1 melanin biological agent, a preparation method and application. The composition comprises tripeptide-1, and further comprises acetyl hexapeptide-8, a ginseng extract, a polygonum multiflorum extract, a ganoderma atrum extract, a pseudo-ginseng extract, castor oil, an angelica sinensis extract and a mixed solvent. The biological preparation can effectively promote the production of collagen and elastin, increase the blood vessel growth and antioxidant ability, stimulate the production of related growth factors, and help the skin to recover the self-repairing ability; the shampoo contains various nutritional ingredients extracted from plants, and can nourish scalp, promote hair growth, promote melanin increase and reduce the growth speed of white hair.

Description

Technical Field

[0001] The present invention relates to the technical field of hair nutrition agents, and in particular to a tripeptide-1 melanin biological preparation, a preparation method and an application thereof. Background Art

[0002] Data from the World Population Network shows that there are 280 million people aged 60 and above, accounting for 19.8%, which means that the proportion of people with gray hair will be much higher than this proportion. With age increase and due to bad habits of modern people, the scalp hair follicles are gradually damaged and atrophied, and the number of melanocytes decreases, causing the hair to turn gray.

[0003] In order to improve the dyeing effect, traditional hair dyes often contain ingredients that aggravate the damage to the scalp environment. Each time you dye your hair, you will increase the number of white hairs by 2% to 5%. Long-term chemical hair dyeing is most harmful to the internal organs of the body, especially the liver and kidneys. It can cause human cell mutations and significantly increase the risk of cancer. In addition, these hair dyes can also destroy red blood cells and cause anemia. People who dye their hair for a long time are prone to headaches, dizziness, lack of energy, sore eyes, tears in the wind, a significant decrease in memory, edema of the eyelid skin, whitening of the scalp, and a high incidence of scleroderma. Frequent use of such hair dyes will greatly affect the health of the human body due to the harmful ingredients in them.

[0004] The technology of white-to-blackening has become a popular trend in recent years and has attracted widespread attention. However, the existing technology still has great problems, and the existing inventions focus on the color change of hair and ignore the injection of hair nutrition, resulting in these products often treating the symptoms but not the root cause, and it is difficult to provide nutrition and increase melanin from the root. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a tripeptide-1 melanin biological preparation, a preparation method and an application thereof.

[0006] The technical solution of the present invention to solve the above technical problems is as follows:

[0007] The invention provides a tripeptide-1 melanin biological preparation. The preparation comprises tripeptide-1, acetyl hexapeptide-8, ginseng extract, polygonum multiflorum extract, black ganoderma lucidum extract, notoginseng extract, castor oil, angelica extract and a mixed solvent.

[0008] Based on the above technical solution, the present invention can also be improved as follows.

[0009] Furthermore, the mixed solvent includes water, propylene glycol and an antioxidant.

[0010] Furthermore, the mass percentage of the tripeptide-1 is 1.5% to 3.5%.

[0011] Furthermore, in the preparation, the mass percentage of acetyl hexapeptide-8 is 1.5% to 2.5%, the mass percentage of ginseng extract is 0.5% to 1%, the mass percentage of Polygonum multiflorum extract is 0.4% to 2.8%, the mass percentage of black ganoderma lucidum extract is 0.5 to 1.5%, the mass percentage of Panax notoginseng extract is 0.2 to 0.8%, the mass percentage of castor oil is 0.1 to 0.5%, the mass percentage of angelica extract is 0.01 to 0.08%, and the balance is the mixed solvent.

[0012] Furthermore, in the preparation, the mass percentage of acetyl hexapeptide-8 is 2%, the mass percentage of ginseng extract is 0.75%, the mass percentage of Polygonum multiflorum extract is 2%, the mass percentage of black ganoderma extract is 1%, the mass percentage of Panax notoginseng extract is 0.5%, the mass percentage of castor oil is 0.2%, the mass percentage of Angelica sinensis extract is 0.05%, and the remainder is the mixed solvent.

[0013] Furthermore, the antioxidant is phenoxyethanol, and the mass percentage of the phenoxyethanol is 0.3-0.6%.

[0014] The present invention also provides a method for preparing a tripeptide-1 melanin biological preparation, comprising the following steps:

[0015] S1, mixing the tripeptide-1, the acetyl hexapeptide-8, the ginseng extract, the polygonum multiflorum extract, the black ganoderma extract, the notoginseng extract, the castor oil and the angelica extract according to a certain proportion;

[0016] S2, preparing the mixed solvent, and mixing the mixture obtained in step S1 with the mixed solvent;

[0017] S3, stabilizing the mixture prepared in step S2.

[0018] Furthermore, in step S3, the stabilization treatment includes a step of adjusting pH, wherein the pH is 6-7.

[0019] The present invention also provides a use of the biological preparation as described above, wherein the biological preparation is used for preparing a scalp nutrient.

[0020] The present invention also provides a scalp nutrient, comprising the biological preparation as described above.

[0021] The beneficial effects of the present invention are:

[0022] (1) The tripeptide-1 melanin biological preparation of the present invention, with the addition of tripeptide-1, can effectively promote the production of collagen and elastin, increase blood vessel growth and antioxidant capacity, and stimulate the production of related growth factors, helping the skin to restore its self-repair ability;

[0023] (2) The tripeptide-1 melanin biological preparation of the present invention contains a variety of nutrients extracted from plants, which can nourish the scalp and promote hair growth;

[0024] (3) The tripeptide-1 melanin biological preparation of the present invention can promote the increase of melanin and reduce the growth rate of gray hair;

[0025] (3) The tripeptide-1 melanin biological preparation of the present invention has a simple method of use, a wider range of use, and stronger adaptability;

[0026] (5) The tripeptide-1 melanin biological preparation of the present invention has safe and effective ingredients and is applicable to a wider range of people;

[0027] (6) The preparation method of the tripeptide-1 melanin biological agent of the present invention has simple steps, low cost, high efficiency, and is suitable for industrial promotion. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 This is a comparison chart of the tripeptide-1 melanin biological preparation of the present invention, before and after use of volunteer 1 in Example 2, Figure 1 a in the middle is before use, Figure 1 b in the middle means after use;

[0029] Figure 2 This is a comparison chart of the tripeptide-1 melanin biological preparation of the present invention, before and after use of volunteer 2 in Example 2, Figure 2 a in the middle is before use, Figure 2 b in the middle means after use. DETAILED DESCRIPTION

[0030] The principles and features of the present invention are described below in conjunction with the accompanying drawings. The examples given are only used to explain the present invention and are not used to limit the scope of the present invention.

[0031] The tripeptide-1 melanin biological preparation of the present invention comprises tripeptide-1, acetyl hexapeptide-8, ginseng extract, polygonum multiflorum extract, black ganoderma extract, notoginseng extract, castor oil, angelica extract and a mixed solvent.

[0032] The tripeptide-1 melanin biological preparation of the present invention contains a variety of nutrients extracted from plants, which are the nutrients required by hair and scalp. The preparation can effectively supplement scalp nutrition, not only nourish the scalp and promote hair growth, but also promote the increase of melanin and reduce the growth rate of gray hair.

[0033] In the biological preparation of the present invention, tripeptide-1 is particularly used. Biotin tripeptide-1 (GHK) is a tripeptide that combines vitamin H and Matrikine series GHK, also known as dermal growth promoting factor, and its chemical structure is as follows:

[0034]

[0035] As a signal peptide, tripeptide-1 can act on the dermis, effectively promote the production of collagen and elastin, increase blood vessel growth and antioxidant capacity, and stimulate the production of related growth factors to help the skin restore its ability to repair itself. The use of tripeptide-1 can increase cell vitality without hurting or irritating the skin, gradually repair the lost collagen in the body, and achieve the purpose of wrinkle removal and anti-aging. Therefore, it can effectively inhibit the aging rate of the scalp and reduce the growth of gray hair when acting on the skin.

[0036] Ginseng can help hair growth, dilate skin capillaries, accelerate blood circulation, enhance cell vitality, increase the nutritional supply of hair follicles, and increase the hair's resistance to shedding and elongation. Therefore, ginseng extract has a good beauty and hair growth effect, and can make hair better.

[0037] Polygonum multiflorum has the effects of blackening hair, nourishing blood, replenishing essence and marrow, and nourishing the liver and kidneys. This is not only recorded in ancient books, but also confirmed by modern science. Therefore, Polygonum multiflorum extract has the effects of blackening hair, promoting hair growth, and treating gray hair and hair loss in both drug prescriptions and dietotherapy prescriptions.

[0038] Black Ganoderma lucidum is rich in trace elements such as calcium, zinc, iron, copper, phosphorus, potassium, sodium, selenium, germanium, etc. Among them, copper plays a key role in the formation of pigments in the body and can promote the production and development of collagen. Therefore, black Ganoderma lucidum extract can make hair darker and brighter.

[0039] Panax notoginseng extract can promote blood circulation and improve scalp microcirculation, which may have a certain promoting effect on hair growth.

[0040] Angelica extract can nourish the skin and hair, make the hair black and shiny, strengthen the hair, and effectively prevent yellow and gray hair.

[0041] Castor oil is mainly used to treat hair loss or gray hair. It can promote hair growth, moisturize hair, make hair shiny, and prevent and treat scalp infections. Regular use of castor oil as a moisturizer can improve the look and feel of dry hair and help offset the damage caused by chemical treatments.

[0042] Preferably, the mass percentage of tripeptide-1 is 1.5% to 3.5%; this mass percentage of tripeptide-1 has the best scalp nourishing effect; if the content is too much, it will not further improve the use effect, but increase the cost, and if the content is too little, it will significantly reduce the effect.

[0043] Preferably, in the biological preparation, the mass percentage of acetyl hexapeptide-8 is 1.5% to 2.5%, the mass percentage of ginseng extract is 0.5% to 1%, the mass percentage of Polygonum multiflorum extract is 0.4% to 2.8%, the mass percentage of black ganoderma lucidum extract is 0.5 to 1.5%, the mass percentage of Panax notoginseng extract is 0.2 to 0.8%, the mass percentage of castor oil is 0.1 to 0.5%, the mass percentage of angelica extract is 0.01 to 0.08%, and the remainder is a mixed solvent.

[0044] Preferably, in the preparation, the mass percentage of acetyl hexapeptide-8 is 2%, the mass percentage of ginseng extract is 0.75%, the mass percentage of Polygonum multiflorum extract is 2%, the mass percentage of black ganoderma lucidum extract is 1%, the mass percentage of Panax notoginseng extract is 0.5%, the mass percentage of castor oil is 0.2%, the mass percentage of Angelica sinensis extract is 0.05%, and the remainder is the mixed solvent.

[0045] Preferably, the antioxidant is phenoxyethanol, and the mass percentage of phenoxyethanol is 0.3-0.6%.

[0046] The preparation method of the hair nourishing agent for turning white hair into black of the present invention comprises the following steps:

[0047] S1. Mix tripeptide-1, acetyl hexapeptide-8, ginseng extract, Polygonum multiflorum extract, black ganoderma lucidum extract, Panax notoginseng extract, castor oil and angelica extract according to the proportion.

[0048] Each extract of the present invention is commercially available.

[0049] Preferably, the mixing method is to mix and stir for 10 minutes at a rotation speed of 2000 / min.

[0050] S2, preparing a mixed solvent, and mixing the mixture obtained in step S1 with the mixed solvent.

[0051] Preferably, the mixed solvent is water and propylene glycol.

[0052] S3. Adjust the pH value of the mixture prepared in step S2 to 6-7 to obtain a biological preparation.

[0053] Preferably, after adjusting the pH value, an antioxidant is added to the mixture, and the mixture is mixed evenly to obtain a biological preparation.

[0054] The biological preparation of the present invention can be used to prepare a scalp nutrient.

[0055] The scalp nutrient of the present invention includes the biological preparation as described above. The scalp nutrient can be shampoo, conditioner, nourishing agent applied to the scalp, etc.

[0056] The present invention is described in detail below through specific examples.

[0057] Example 1

[0058] This example examines the effect of tripeptide-1 (GHK) on the proliferation of keratinocytes.

[0059] The specific detection method is to incubate the scalp hair follicle tissue cells with 0.1-100mM / L GHK at 37°C for 72h and perform a 72h proliferation experiment. The results are expressed as the optical density value or absorbance value (0.D.) after the MTT method. The results show that the scalp hair follicle cells proliferate by 10%, indicating that tripeptide-1 has a significant effect on promoting the proliferation of keratinocytes and shows a good concentration correlation.

[0060] Example 2

[0061] This example examines the effect of the biological preparation of the present invention on promoting the increase of melanin.

[0062] The specific ingredients of the biological preparation of this embodiment are: 1% acetyl hexapeptide-8, 0.8% black ganoderma extract, 0.75% ginseng extract, 2% Polygonum multiflorum extract, 1.5% Artemisia argyi root extract, 1.8% Salvia miltiorrhiza extract, 3.5% Platycladus orientalis leaf extract, 2% blueberry extract, 5.5% castor oil, 3% oligopeptide-1, 2.5% tripeptide-1, 0.5% vitamin C, 0.75% vitamin E, 0.2% zinc, 0.05% copper, and the remainder is a mixture of water, propylene glycol and antioxidants, and the mass percentage of phenoxyethanol is 0.5%.

[0063] Volunteer 1 and volunteer 2 were asked to apply the biological preparation of this embodiment respectively. The application cycle was 8 days, once a day, and the effect was as follows: Figure 1 and 2 shown.

[0064] pass Figure 1 and Figure 2 It can be seen that the biological preparation of the present invention can significantly promote the production of collagen and elastin, increase blood vessel growth and antioxidant capacity, and stimulate the production of related growth factors, help the skin restore its self-repair ability, promote the increase of melanin and reduce the growth rate of gray hair.

[0065] In the description of the present invention, it should be noted that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0066] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0067] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being "above", "above" or "above" a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being "below", "below" or "below" a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0068] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradiction.

[0069] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0070] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A tripeptide-1 melanin biological preparation, characterized in that: The ingredients of the preparation include tripeptide-1, acetyl hexapeptide-8, ginseng extract, polygonum multiflorum extract, black ganoderma lucidum extract, notoginseng extract, castor oil, angelica extract and a mixed solvent.

2. A tripeptide-1 melanin biological preparation according to claim 1, characterized in that: The mixed solvent includes water, propylene glycol and an antioxidant.

3. A tripeptide-1 melanin biological preparation according to claim 2, characterized in that: The mass percentage of the tripeptide-1 is 1.5% to 3.5%.

4. A tripeptide-1 melanin biological preparation according to claim 3, characterized in that: In the preparation, the mass percentage of acetyl hexapeptide-8 is 1.5% to 2.5%, the mass percentage of ginseng extract is 0.5% to 1%, the mass percentage of Polygonum multiflorum extract is 0.4% to 2.8%, the mass percentage of black ganoderma lucidum extract is 0.5% to 1.5%, the mass percentage of Panax notoginseng extract is 0.2% to 0.8%, the mass percentage of castor oil is 0.1% to 0.5%, the mass percentage of angelica extract is 0.01% to 0.08%, and the balance is the mixed solvent.

5. A tripeptide-1 melanin biological preparation according to claim 4, characterized in that: In the preparation, the mass percentage of acetyl hexapeptide-8 is 2%, the mass percentage of ginseng extract is 0.75%, the mass percentage of Polygonum multiflorum extract is 2%, the mass percentage of black ganoderma lucidum extract is 1%, the mass percentage of Panax notoginseng extract is 0.5%, the mass percentage of castor oil is 0.2%, the mass percentage of Angelica sinensis extract is 0.05%, and the balance is the mixed solvent.

6. A tripeptide-1 melanin biological preparation according to any one of claims 2 to 5, characterized in that: The antioxidant is phenoxyethanol, and the mass percentage of the phenoxyethanol is 0.3-0.6%.

7. A method for preparing the tripeptide-1 melanin biological agent according to any one of claims 1 to 6, characterized in that: The following steps are involved: S1, mixing the tripeptide-1, the acetyl hexapeptide-8, the ginseng extract, the polygonum multiflorum extract, the black ganoderma extract, the notoginseng extract, the castor oil and the angelica extract according to a certain proportion; S2, preparing the mixed solvent, and mixing the mixture obtained in step S1 with the mixed solvent; S3, stabilizing the mixture prepared in step S2.

8. The method for preparing a tripeptide-1 melanin biological preparation according to claim 7, characterized in that: In step S3, the stabilization treatment includes a step of adjusting pH, wherein the pH is 6-7.

9. A use of a biological agent as claimed in any one of claims 1 to 6, characterized in that: The biological preparation is used for preparing a scalp nutrient.

10. A scalp nutrient, characterized in that: The method comprises the biological agent according to any one of claims 1 to 6.

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