System for processing health indicator value of patient

Abstract

The invention relates to a system for processing health indicator values in order to determine a numerical score representing a general health of a patient, said system comprising a database (1) comprising a series of indicator values for different health aspects calibrated using standardized values. A plurality of input devices (2A, 2B, 2C) are each associated with at least one patient. A number of intermediate servers (7) are each associated with the input devices (2A, 2B, 2C) of one or more patients and communicate with a master server (8) comprising a computing unit (4) for all intermediate servers. Raw data of indicators of different aspects of patient health received by the input means (2A, 2B, 2C) is calibrated and sent to the master server (8), and its calculated score is stored in a display device (5), such as a smartphone associated with the patient's input means.

Description

[0001] The object of the present invention is a system for processing the health indicator values ​​of at least one patient to determine for each patient a numerical score representing the patient's general health in order to help that person restore, optimize and maintain their health and to ensure and increase their well-being and longevity.

[0002] The applicant's publication WO2016110734 has disclosed a method of evaluating a score representing the health of a patient based on the following considerations.

[0003] Instant access to scientific research results has led to an astonishing acceleration in our understanding of human physiology. Despite this, patients are still too often treated based on faulty or incomplete concepts. The approach is to base treatments only on the most recently validated research in order to provide the best possible care for patients.

[0004] Health is the result of a balance between the two parts of the body: the gastrointestinal system or digestive brain and the nervous system or brain.

[0005] The digestive brain must provide energy, essential nutrients, vitamins, and trace elements. It must also act as a protective barrier to keep out unwanted invaders in the same way as the skin, lung mucosa, and blood-brain barrier. It is in constant communication with the brain through the enteric nervous system and a host of hormones, lipoproteins, interleukins, and other substances, some of which remain unknown.

[0006] The digestive interface needs to be considered as a whole. This includes the thousands of species of bacteria found in the human digestive tract. They live in symbiosis with generations of individuals for thousands of years. Each individual eats according to the results of its own metabolism. These bacteria provide about 50% of each individual's basic nutrient intake. They also produce many lipoproteins that are able to transmit information to the brain. They play an important role in immune function and, most importantly, in the production of inflammation, which can affect the entire body. The latest scientific evidence clearly demonstrates the connection between the intestinal flora and certain diseases, such as obesity and type 2 diabetes. Ensuring the quality of an individual's intestinal flora is fundamental to maintaining good health.

[0007] The intestinal mucosa acts as a true barrier. It consists of juxtaposed cells held together by tight junctions. The integrity of these links is essential. The intestinal mucosa is the border between the outside and the inside of the body. Therefore, it is not surprising that more than half of an individual's immune defense is located in the digestive tract. When foreign bacteria or proteins penetrate this protective layer, the immune system must take over to clear it out of the individual. This can mean a large energy expenditure for the body. This energy will no longer be available for other functions. Therefore, it is crucial to ensure that the intestinal cells (enterocytes) receive optimal nutrition and that nothing attacks the tight junctions.

[0008] The brain is the driver, regulator and coordinator of all basic functions. In order for this brain to function properly, it needs to be well protected by the digestive brain and constantly activated. Physical activity, through movement that stimulates the neurons of the cerebellum, is the most important activation. Other stimuli, sight, hearing, taste and touch also play this role.

[0009] During the course of evolution, the brain has changed. Different areas can be distinguished depending on the stage of development. The primitive brain, known as the nervous system or reptilian system, is the most important area in terms of health. It manages basic functions and ensures the proper coordination of the individual's various cycles throughout the day. Other areas have a regulatory role in the reptilian brain.

[0010] Therefore, if an individual is to know their health status, it is crucial to assess the function of all these areas. This has been made possible by new discoveries in the field of functional neurology. Therefore, certain brain areas can be stimulated or inhibited to change their regulatory effect on the nervous system.

[0011] Furthermore, a hallmark of cellular distress is well known. It is oxidative stress.

[0012] Moreover, both doctors and patients are becoming less available, and while finding an appointment when sick remains manageable, scheduling an appointment for medical follow-up is increasingly complex.

[0013] Today, people have apps on their smartphones that, for example, track their athletic performance or sleep at night, as well as medical records kept by every doctor they visit.

[0014] The object of the present invention is a system for processing the health indicator values ​​of at least one patient to determine for each patient a numerical score representing the patient's general health to help that person restore, optimize and maintain their health and to ensure and increase their well-being and longevity.

[0015] The present invention relates to a system for processing health indicator values ​​of a patient to determine a numerical score representing the general health of the patient for each individual patient in a plurality of patients. The system comprises: a database comprising a series of indicator values ​​of different health aspects calibrated using standardized values; a device for inputting a series of health indicator data of the patient in the standardized values; a unit for storing data received by the input device; and a unit for calculating a numerical score representing the general health of the patient based on a weighting of the health indicator data values ​​of the patient.

[0016] Such a system is derived from a specific implementation of the method described in WO2016110734 through a generalization of health indicator values ​​and their groupings and applied weightings, while the method of WO2016110734 to be described later involves defined health indicator values ​​and their groupings and specific weightings.

[0017] It is an object of the present invention to provide a system that enables the method of WO2016110734 to calculate a health score to be implemented in an easier way, and in particular by giving each patient quicker access to the score, which is particularly advantageous when the system treats a large number of patients.

[0018] It is another object of the present invention to provide such a system that is capable of utilizing other health indicator values ​​and implementing other methods based on other weightings of the patient's health indicator values.

[0019] According to the invention, the system comprises: a plurality of input devices, each of which is associated with at least one patient; a plurality of intermediate servers, each of which is associated with the input devices of one or more patients; and a master server for all intermediate servers, the master server comprising a computing unit. The electronic sensor device comprises at least one sensor associated with the input device for receiving raw data indicators of different aspects of the patient's health from these input devices. A calibration device integrated into the input device, the intermediate server or the master server is arranged to calibrate the raw sensor data according to the calibrated standardized values ​​from the database and to pass the calibration values ​​to the storage unit, which is arranged to send the calibration data to the computing unit of the master server.

[0020] Each intermediate server forms with the main server a platform for exchanging health score data calculated by the computing unit of the main server. The data exchange platform is arranged to store the general health score of each patient in a display device associated with the patient-specific input device. The computing unit of the main server is arranged to calculate the health score of the patient immediately whenever the input device integrates patient health indicator data (whose value affects the calculation of the health score) so as to automatically update the general health score of each patient stored in the display device.

[0021] The applicant's WO2016110734 defines a method for determining a numerical score representing a patient's general health based on a series of indicators related to the patient's general health and stored in a database, which can be implemented by the system of the present invention. The method comprises the following steps:

[0022] - in an initial calibration step, a database is established according to a series of indicators related to the general state of health of the patient, the series of indicators including an indicator related to oxidative stress, an indicator related to the functioning of the digestive brain, an indicator related to the functioning of the reptilian brain and an indicator related to the patient's physical abilities coupled with information about the general state of health of the patient, each individual indicator being assigned a value between 0 and 10, and then

[0023] - Perform statistical analysis on this database in order to

[0024] - establishing a score ranging from 0 to 10 for each of said patient indicators based on the measured values ​​of the patient's health status indicators relative to the reference values,

[0025] - Establishment of four groups consisting of said indicators stored in the database, namely:

[0026] A group of oxidative stress indicators, hereinafter referred to as group 1;

[0027] A group of indicators related to digestive brain function, hereinafter referred to as Group 2;

[0028] a set of indicators related to the function of the reptilian brain, hereinafter referred to as Group 3; and

[0029] a set of indicators related to the patient's physical capabilities coupled with information about the patient's general state of health, hereinafter referred to as Group 4, and

[0030] - for a patient, assigning a value between 0 and 100 to each group depending on the patient's indicator score, the value of each group being determined by the relationship 10*(the sum of the scores from 0 to 10 for each of the N indicators in the indicator group considered in calculating the value of each group) / N,

[0031] - Then, a health score S specific to the patient's general health is calculated on a scale between 0 and 100 using the following formula:

[0032] S=(∑1 * (Group 1 value)+2 * (Group 2 value)+2 * (Group 3 value)+3 * (Group 4 value)) / 8.

[0033] Numerical scores are determined on a scale of 0 to 100. The value of each group also varies from 0 to 100, while the value of each indicator varies from 0 to 10.

[0034] In a preferred embodiment of the method, the score associated with the digestion analysis, the oxidized LDL (low-density lipoprotein) value, the HOMA (homoestasis model assessment) index, the selenium value, the ferritin value and the zinc value are used to determine the group 1 value. Group 1 gives the value of oxidative stress.

[0035] Oxidative stress is the root of many chronic diseases and is the result of highly reactive molecules linked to oxygen, constantly destroying our most important molecules and ultimately making us sick. Paradoxically, these highly reactive molecules, called free radicals, have important biological functions, especially in cell signaling, and are useful to the individual. In addition, they can attack all components of living organisms and promote chronic diseases such as cataracts, cancer, coronary heart disease, diabetes, kidney failure, Alzheimer's, Parkinson's, etc. In theory, these free radicals are neutralized or processed by the body's own protective mechanisms, called antioxidants. Today, antioxidants are becoming the key to longevity and our allies in the fight against modern diseases. These are protective elements that intervene by scavenging free radicals. Oxidative stress can lead to physical or neurological fatigue, whether temporary or permanent, as well as eating disorders.

[0036] In one embodiment of the method, the scores associated with digestive analysis, CRP (C-reactive protein) values, HOMA index and ω6 / ω3 ratio are used to determine Group 2 values. Group 2 gives values ​​for digestive inflammation.

[0037] In one embodiment of the method, Group 3 values ​​are determined using scores associated with a health questionnaire, values ​​associated with a measure of perceived time, homocysteine ​​values, ω3 index values, scores associated with parameters of cardiac variability specifically during the night, root mean square values ​​of successive differences in heart rate, LF / HF (low frequency / high frequency) ratios reflecting overall sympathovagal balance, restorative sleep index values, and values ​​associated with a measure of the overall activity of the autonomic nervous system. Group 3 gives values ​​for brain function.

[0038] Specifically, measuring nervous system activity through cardiac variability during exercise and over 24 hours enables measurement of sleep quality and individual recovery capacity. This measurement is essential for patient follow-up. The more intensive the program, the greater the need for improvement.

[0039] In one embodiment of the method, the value of group 4 is determined specifically by a health questionnaire (the results of which are analyzed and weighted), a sports test according to speed or strength, a score associated with the measurement of heart amplitude, a score associated with a speed test and a root mean square value of a continuous heart rate difference equal to or less than 10, a somatosensory test, a visual test, a vestibular test, a ferritin value, a HOMA index, a zinc value, a selenium value, a CRP value, and an immune questionnaire value. Group 4 gives a value for general health. This is because a complete examination based on a comprehensive functional neurological examination makes it possible to determine the functional level of the nervous system and the control ability of higher cortical areas. Individual functions and interactions of the three main sensory systems of the periphery, vestibule, and eye are also tested. We also assess the adaptability of the motor system, the visual ability during head movement, and the functional ability of the lower limb joints. Each index has a value between 0 and 10.

[0040] For example, the group 1 value may be determined using the following formula: Group 1 value = ∑(((3 * Digestion analysis value)+(3 * Oxidized LDL value) +2 * (zinc value + selenium value) + HOMA index value + ferritin value) * 10) / 12.

[0041] The Group 2 value can be determined using the following formula: Group 2 value = ∑ (((5 * CRP value)+(3 * Digestion analysis value) +2 * (ω6 / ω3 value) + HOMA index value) * 10) / 11.

[0042] The Group 3 value can be determined using the following formula: Group 3 value = ∑(((3 * Health questionnaire value)+(4 * Perceived time measurement)+(5 * Autonomic nervous system measurements)+(3 * Overnight values ​​of cardiac variability parameters HF)+(3 * Overnight value of cardiac variability parameter LF)+(3 * Homocysteine ​​RMS lF)+(3 * RMS value of continuous heart rate difference)+(2 * Homocysteine ​​value) + (LF / HF ratio) + ω3 index value + sleep recovery index value) * 10) / 26.

[0043] Finally, the Group 4 value can be determined using the following formula: Group 4 value = ∑(((3 * Health survey volume value)+(5 * Speed ​​Effort Test Value)+(5 *Strength Effort Test Value)+(4 * Heart amplitude)+(4 * The RMS value of the speed test value and the continuous heart rate difference) + (2 * Somatosensory test value)+(2 * Visual test value)+(3 * Vestibular test value)+(2 * Ferritin value) + Homa index value + zinc value + selenium value + (4 * CRP value)+(2 * Immunity test value) * 10) / 39.

[0044] In summary, the method of WO2016110734 determines a numerical score representing the general health of a patient based on the weighting of the patient's health indicator values.

[0045] In order to perform the method described in WO2016110734, the calculation unit calculates the score stored in a storage unit accessible from a main server, an intermediate server or an electronic capture device.

[0046] In one embodiment of the invention, each of the input devices comprises a keyboard for manual data entry and an input for computerized data.

[0047] In this embodiment, each intermediate server and computing unit processes the data of each patient separately.

[0048] Also according to this embodiment, each of the input devices comprises means for storing and displaying a general health score for each patient.

[0049] In one embodiment, the calculation unit is parameterized to calculate the health score based on at least three and preferably at least four parameters representing different health indicator values.

[0050] According to this embodiment, the calculation unit is configured to calculate the health score according to weighted values ​​of four groups of parameters, which represent different values ​​of health indicators corresponding to the patient's oxidative stress index, digestive brain function, reptile brain function and general health status, respectively.

[0051] Still according to this embodiment, the calculation unit is configured to calculate the health score by considering the heart amplitude, the perception time and the value of the ω3 index.

[0052] In one embodiment, the electronic sensing device of the input means is a smart phone, a connected watch and / or a heart rate strap.

[0053] In another embodiment, the input means with the electronic sensor device and the intermediate server are grouped together in a single device, or integrated into multiple devices that are grouped together in the same location, typically a doctor's office.

[0054] Thus, a system according to the invention will have as many input devices as there are doctors, each with an intermediate server, each doctor taking care of one or more patients.

[0055] The characteristics of the invention will become more apparent after reading several embodiments given purely by way of example, which are in no way limited by reference to the schematic diagrams in which:

[0056] - Figure 1 shows a schematic diagram of a portion of a system illustrating tracking of a patient through the patient's smartphone, an intermediate server, and a main server; and

[0057] - Figure 2 shows a schematic diagram of a system illustrating monitoring of five patients each via a smartphone, two intermediate servers and a main server;

[0058] Figure 1 A portion of a system for processing health indicator values ​​of a patient to determine a numerical score representing the general health of the patient is shown. The system comprises: a database 1 comprising a series of health indicator values ​​calibrated using standardized values; means 2A, 2B, 2C for inputting a series of health indicator data of the patient in the standardized values; units 3A, 3B for storing data received by the input means 2A, 2B, 2C; and a unit 4 for calculating a numerical score representing the general health of the patient based on a weighting of the health indicator data values ​​of the patient.

[0059] In this example, the database 1 and the storage unit 3A are located on a host server 8 where the computing unit 4 is located.

[0060] In this example, the input device 2C comprises a smartphone 5 having a sensor 6 arranged to receive raw health indicator data from a patient and to calibrate the raw data using electronic components according to standardized database values.

[0061] In this embodiment, the smartphone 5 is connected to a connected watch 9 and a heart rate belt 10 .

[0062] The storage unit 3B is integrated into the intermediate server 7 , while the storage unit 3A is integrated into the main server 8 , and the computing unit 4 is completely integrated into the main server 8 .

[0063] Database 1 contains a set of indicators related to oxidative stress, to the functioning of the digestive brain, to the functioning of the reptilian brain and to the patient's physical abilities coupled with information about the patient's general state of health, quantified, for example, as indicated in WO2016110734.

[0064] The various input devices 2A, 2B, 2C correspond to the keyboard of the main server 8, the keyboard of the intermediate server 7 or the keyboard of the smart phone 5. These various input devices are arranged to input the original values ​​of all health indicators according to the groups stored in the database 1. For example, the data input via the smart phone 5 or the intermediate server 7 is calibrated by the main server 8, which immediately returns the health score. In another example, the captured data is automatically calibrated on the smart phone 5 or the intermediate server 7 and is passed to the main server 8 to calculate the health score.

[0065] exist Figure 2 In the example shown, each intermediate server 7 is managed by each doctor, so that the doctors can monitor the progress of each of their patients. The intermediate servers 7 communicate with a main server 8, which together with each intermediate server 7 constitutes a data exchange platform for the health score calculated by the calculation unit 4 and for storing the general health score of each in the storage and display means associated with the specific input means for the patient, usually in the intermediate server 7, which sends the score to the smartphone 5.

[0066] The unit 4 for calculating a numerical score representative of the patient's general health is arranged to calculate the patient's health score as soon as a value of a health indicator influencing said health score is manually or automatically integrated into the data input device 2A, 2B, 2C. In this way, the general health score of each patient stored in the data exchange platform on the one hand and in the storage and display means associated with the patient's specific input device on the other hand is automatically updated.

[0067] For example, for each sports activity, Figure 1 The patient's smartphone 5, shown connected to a connected watch 9 and heart rate belt 10, records data affecting the health score and sends it to an intermediate server 7, which in turn sends it to the main server 8. In this way, the patient's health score is automatically updated by the calculation unit 4 located in the main server 8.

[0068] The computing unit 4 in the main server 8 may, for example, comprise a computer module programmed to calculate a numerical score representing the general health of the patient based on a weighting of the patient's health indicator values ​​(eg according to the algorithm described in publication WO201611734).

[0069] In the same way, when the doctor enters a value that affects the patient's health score on the keyboard 2B of the intermediate server 7, specifically in the case of blood test results, the calculation unit 4 in the main server 8 immediately recalculates the patient's health score and the patient can immediately view their new health score, for example on their smartphone 5.

[0070] The phone app enables patients to access their health score and track its progress over time (by day, week or month).

[0071] The measured values ​​of the indicators are used to establish a score for each of the indicators based on the measured values ​​relative to the baseline value.

[0072] In order to perform the method described in WO2016110734, a value corresponding to each of the four groups consisting of the indicators is input into the input devices 2A, 2B, 2C, each of the groups representing information corresponding to the following items respectively: oxidative stress, hereinafter referred to as Group 1; gastrointestinal system function, hereinafter referred to as Group 2; nervous system function, hereinafter referred to as Group 3; and the patient's physical ability coupled with information about the general state of the patient's health, hereinafter referred to as Group 4.

[0073] Finally, the computing unit 4 located in the main server 8 uses a computer algorithm to calculate the patient-specific health score S on a scale from 0 to 100 using the following formula:

[0074] S = ∑(group 1 value + (2 * Group 2 value)+(2 * Group 3 values) + (3 groups 4 values) / (2 * number of groups).

[0075] For example, a patient with a Group 1 value of 49.17, a Group 2 value of 47.27, a Group 3 value of 86.92, and a Group 4 value of 99.12 would have a health score S = 76.86.

[0076] In this example, the closer the health score value is to 100, the healthier the patient is.

[0077] Figure 2 A system for processing index values ​​of health of five patients to determine a numerical score representing the general health of each patient is shown. Figure 1, the system includes a main server 8 and a database 1 in an intermediate server 7. The database stores a series of health indicator values ​​calibrated according to standardized values. Each intermediate server 7 is associated with a smart phone 5 of each patient, thereby constituting a device for inputting a series of health indicator data for each patient from standardized values. The system also includes: a storage unit 3B in the intermediate server 7 and a storage unit 3A in the main server 8, for storing data received by the input devices 2A, 2B, 2C; and a calculation unit 4 in the main server 8, which is used to calculate a numerical score representing general health based on the weighting of the health indicator values.

[0078] In this example, the input device comprises one smartphone 5 for each patient, i.e. five smartphones 5, each smartphone comprising a sensor 6 arranged to receive raw health indicator data from each patient and calibrate the raw data according to standardized values ​​from a database (either in the smartphone 5 or in an intermediate server 7).

[0079] The storage unit is integrated in each smartphone 5 , in each of the two intermediate servers 7 and in the main server 8 , wherein the main server 8 and the two intermediate servers 7 receive data calibrated to standardized values ​​from the database via communication means.

[0080] In this example, the first intermediate server 7 tracks two patients and the second intermediate server 7 tracks three patients. In this way, each doctor can monitor the progress of each of their patients. Each intermediate server 7 communicates with the main server 8, thereby constituting a data exchange platform for the health score calculated by the calculation unit 4 and for storing the general health score of each patient at a location associated with said input device specific to the patient, i.e. in the smartphone 5.

[0081] The unit 4 for calculating a numerical score representing the patient's general health is arranged to calculate the patient's health score immediately whenever data of health indicator values ​​affecting the health score are manually or automatically integrated, so that the general health score of each patient stored in the data exchange platform and in the smart phone 5 constituting a storage / display device associated with the patient's specific input device is automatically updated by the main server 8.

[0082] For example, after each sports activity, each patient's smartphone 5 records data affecting the health score and sends this data to the storage unit 3A, 3B, which sends this data to the main server 8. In this way, the patient's health score is automatically updated by the main server 8.

[0083] In the same way, when each of the two doctors enters a value affecting the health score on the keyboard 2B of the intermediate server 7, in particular in the case of blood test results, each patient can immediately view their new health score.

[0084] For example, four months is enough time to establish significant changes with real impact on health. Only after this period of time will improvements in blood balance and sleep quality, which are the best indicators of the patient's reptilian brain function, become apparent. Comparative analysis of pre- and post-procedure evaluations will demonstrate improvements in the patient's health scores.

Claims

1. A system for processing health indicator values ​​to determine, for each individual patient among a plurality of patients, a numerical score representing the general health of the patient, the system comprising: - a database (1) comprising a series of indicator values ​​for different health aspects calibrated using standardized values; Means (2A, 2B, 2C) for inputting a series of health index data of a patient, said data being among said standardized values; - a storage unit (3A, 3B) for data received by the input device (2A, 2B, 2C); and - a unit (4) for calculating a numerical score representing the patient's general health based on the weighting of the patient's health indicator data values; Features The system comprises: - a plurality of input devices (2A, 2B, 2C), each input device of the plurality of input devices being associated with at least one patient; - a plurality of intermediate servers (7), each intermediate server (7) being associated with said input device (2A, 2B, 2C) of one or more patients, a main server (8), which is used for all intermediate servers (7), and which includes the computing unit (4), - an electronic sensor device (5) comprising at least one sensor (6) associated with the input means (2A, 2B, 2C) for receiving raw data indicators of different aspects of the patient's health from these input means (2A, 2B, 2C), and - calibration means, integrated into the input device (2A, 2B, 2C), the intermediate server (7) or the main server (8), to calibrate the raw data from the sensor (6) according to the calibrated standardized values ​​from the database (1) and to transfer the calibration values ​​to the storage unit (3A, 3B), which is arranged to send the calibration data to the calculation unit (4) of the main server (8), in: Each intermediate server (7) together with the main server (8) constitutes a data exchange platform for the health score calculated by the calculation unit (4) of the main server (8), the data exchange platform being arranged to store the general health score of each patient in a display device (5) associated with the input means specific to the patient; and The computing unit (4) of the main server (8) is arranged to calculate the patient's health score immediately whenever the input device (2A, 2B, 2C) integrates patient health indicator data whose value affects the calculation of the health score, so as to automatically update the general health score of each patient stored in the display device (5) associated with the input device specific to the patient.

2. The system according to claim 1, wherein at least one of the input devices (2A, 2B, 2C) comprises a keyboard for manual data entry and an input for computerized data.

3. A system according to claim 1 or 2, comprising a database (1) in the main server (8), or a database in each intermediate server (7).

4. A system according to any one of claims 1, 2 or 3, wherein each of the input means (2A, 2B, 2C) comprises a device (5) for storing and displaying a general health score for each patient.

5. System according to any of the preceding claims, wherein the calculation unit (4) is arranged to calculate the health score based on at least three and preferably at least four parameters representing different health indicator values.

6. The system according to claim 5, wherein the computing unit (4) is configured to calculate the health score based on weighted values ​​of four groups of parameters, the four groups of parameters representing different values ​​of health indicators corresponding to the patient's oxidative stress index, digestive brain function, reptilian brain function and general health status, respectively.

7. The system according to claim 5 or 6, wherein the calculation unit is configured to calculate the health score by considering the heart amplitude, the perception time and the value of the ω3 index.

8. System according to one of the preceding claims, wherein the electronic sensor device (5) of the input means is a smartphone, a connected watch (9) or a heart rate belt (10).

9. A system according to one of the preceding claims, wherein each intermediate server (7) with its input means (2A, 2B, 2C) and the components of the electronic sensor device (5) are grouped into a single device or integrated into several devices grouped at the same location.

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