Ventilation equipment and gas flow adjusting method thereof

Abstract

The invention provides ventilation equipment and a gas flow adjusting method thereof, and the ventilation equipment comprises a gas source interface used for being connected with a gas source; a patient interface for connecting a respiratory system of a patient; a flow delivery device for delivering gas to the patient interface; the pressure sensor is used for acquiring pressure data of the first signal acquisition point; the flow sensor is used for acquiring flow data of a second signal acquisition point; the processor is used for controlling the flow conveying device to convey gas to the patient interface based on the multiple first gas flows and calculating flow characteristic parameters of the patient according to the pressure data and the flow data under the multiple first gas flows; and for controlling the flow delivery device to deliver gas to the patient interface based on the second gas flow. The ventilation equipment has a better ventilation effect when providing respiratory support.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to a ventilation device and a gas flow regulating method of the ventilation device. Background Art

[0002] When the ventilation equipment provides respiratory support to the patient, there is often gas leakage between the patient interface and the patient's connection, which makes the ventilation equipment unable to achieve the expected effect. Taking nasal high-flow oxygen therapy as an example, nasal high-flow oxygen therapy allows the patient to inhale high-flow gas with constant temperature and humidity through a nasal cannula. The high-flow gas produces a certain level of positive end-expiratory pressure and flushes the physiological dead space of the upper respiratory tract, reducing the patient's breathing work. A certain concentration of oxygen can be mixed into the inhaled gas, thereby improving the patient's oxygenation.

[0003] During high-flow oxygen therapy, since there is air leakage at the connection between the high-flow nasal catheter and the nasal cavity, the oxygen inhaled by the patient will be diluted by the air, causing the oxygen concentration of the patient's actual inhaled gas to be lower than the value set by the doctor. Therefore, it is usually necessary to set the flow rate of high-flow oxygen therapy to a value higher than the patient's peak inspiratory flow rate to provide the patient with a stable oxygen concentration.

[0004] At present, it is difficult to measure the peak inspiratory flow of patients during high-flow oxygen therapy, which makes the flow setting of high-flow oxygen therapy a difficult problem in the industry. In the past, doctors mainly relied on experience to estimate the patient's peak inspiratory flow to set the flow. Some researchers also use flow meters to measure the patient's peak inspiratory flow before the patient undergoes high-flow oxygen therapy to determine the flow setting, but this method has low accuracy and poor clinical effect. Summary of the invention

[0005] According to a first aspect, an embodiment provides a ventilation device, comprising:

[0006] Gas source interface, used to connect the gas source;

[0007] A patient interface, used to connect to the patient's breathing system;

[0008] a flow delivery device for delivering gas to the patient interface;

[0009] A pressure sensor, used to obtain pressure data of a first signal collection point;

[0010] A flow sensor, used to obtain flow data of a second signal collection point, wherein the first signal collection point and the second signal collection point are both located between the air source interface of the ventilation device and the patient interface;

[0011] a processor, configured to control the flow delivery device to deliver gas to the patient interface based on a plurality of first gas flow rates, and to calculate a flow characteristic parameter of the patient based on the pressure data and the flow data under the plurality of first gas flow rates; and to control the flow delivery device to deliver gas to the patient interface based on a second gas flow rate to provide respiratory support to the patient, wherein the second gas flow rate is close to or exceeds the gas flow rate inhaled by the patient when the flow characteristic parameter of the patient is calculated;

[0012] The flow characteristic parameter is related to the physiological state of the patient and is used as a reference for determining the second gas flow.

[0013] According to the second aspect, an embodiment provides a method for regulating gas flow of a ventilation device, comprising:

[0014] Acquire pressure data of a first signal collection point;

[0015] Acquire flow data of a second signal collection point, wherein the first signal collection point and the second signal collection point are both located between an air source interface and a patient interface of the ventilation device, the air source interface is used to connect to an air source, and the patient interface is used to connect to a respiratory system of a patient;

[0016] Delivering gas to the patient interface based on a second gas flow rate to provide respiratory support to the patient, wherein the second gas flow rate approaches or exceeds the gas flow rate inhaled by the patient when the patient's flow characteristic parameter is calculated;

[0017] Based on multiple first gas flow rates, gas is delivered to the patient interface, and the patient's flow characteristic parameters are calculated according to the pressure data and the flow data under the multiple first gas flow rates, wherein the flow characteristic parameters are related to the patient's physiological state and are used as a reference for determining the second gas flow rate.

[0018] According to the third aspect, an embodiment provides a computer-readable storage medium, on which a program is stored, and the program can be executed by a processor to implement the method described in the second aspect.

[0019] According to the ventilation device and the gas flow adjustment method of the above-mentioned embodiment, pressure data is obtained at the first signal collection point between the gas source interface and the patient interface, and flow data is obtained at the second signal collection point between the gas source interface and the patient interface. When ventilating the patient, gas is delivered to the patient at multiple first gas flow rates, and the patient's flow characteristic parameters are calculated based on the pressure data and flow data under the multiple first gas flow rates. The flow characteristic parameters can be used as a reference for determining the second gas flow for providing respiratory support. The above process can be completed during the ventilation process. Since the flow characteristic parameters are calculated during the ventilation process, using the flow characteristic parameters as a reference for determining the second gas flow can make the second gas flow better meet the actual needs of the patient. For example, during the period when the patient receives high-flow oxygen therapy, gas can be delivered at multiple first gas flow rates, and then the second gas flow suitable for oxygen therapy is determined based on the obtained flow characteristic parameters, thereby providing the patient with a stable oxygen inhalation concentration and ensuring the ventilation effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 A schematic diagram of the structure of a ventilation device according to an embodiment;

[0021] Figure 2 A diagram showing the relationship between pressure difference and flow data in one embodiment;

[0022] Figure 3 A graph showing pressure data, flow data and proximal pressure changes over time in one embodiment;

[0023] Figure 4 A graph showing the variation of the proximal pressure with time under a plurality of first gas flow rates according to an embodiment;

[0024] Figure 5 is a graph showing the variation of the proximal pressure with time under a first gas flow rate in one embodiment;

[0025] Figure 6 A graph showing the variation of the proximal pressure with time under multiple first gas flow rates in another embodiment;

[0026] Figure 7 The present invention is a flow chart of a method for regulating gas flow of a ventilation device according to an embodiment of the present invention. DETAILED DESCRIPTION

[0027] The present invention is further described in detail below by specific embodiments in conjunction with the accompanying drawings. Wherein similar elements in different embodiments adopt associated similar element numbers. In the following embodiments, many detailed descriptions are for making the present application better understood. However, those skilled in the art can easily recognize that some features can be omitted in different situations, or can be replaced by other elements, materials, methods. In some cases, some operations related to the present application are not shown or described in the specification, this is to avoid the core part of the present application being overwhelmed by too much description, and for those skilled in the art, it is not necessary to describe these related operations in detail, and they can fully understand the related operations according to the description in the specification and the general technical knowledge in the art.

[0028] In addition, the features, operations or characteristics described in the specification can be combined in any appropriate manner to form various implementations. At the same time, the steps or actions in the method description can also be interchanged or adjusted in a manner that is obvious to those skilled in the art. Therefore, the various sequences in the specification and the drawings are only for the purpose of clearly describing a certain embodiment and are not meant to be a required sequence, unless otherwise specified that a certain sequence must be followed.

[0029] The serial numbers of the components in this document, such as "first", "second", etc., are only used to distinguish the objects described and do not have any order or technical meaning. The "connection" and "coupling" mentioned in this application, unless otherwise specified, include direct and indirect connections (couplings).

[0030] Providing respiratory support to a patient as referred to in this application refers to delivering gas to a patient for the purpose of assisting the patient's breathing. For example, delivering gas to a patient during oxygen therapy via high-flow nasal oxygen therapy is providing respiratory support to the patient.

[0031] Current ventilation mainly includes invasive ventilation and non-invasive ventilation, wherein non-invasive ventilation can be connected to the patient's mouth, nose and other parts through components such as masks and nasal catheters, so as to ventilate the patient. These components are collectively referred to as patient interfaces in some embodiments below. There is inevitably gas leakage at the connection between the patient interface and the patient. As a result, when providing respiratory support to the patient, there is an error between the expected gas flow rate and the gas flow rate that the patient can actually inhale. For example, the medical staff estimates that the gas flow rate that the patient currently needs to inhale is N, and accordingly sets the gas flow rate delivered on the ventilation device to M, M>N. Due to gas leakage at the connection between the patient interface and the patient, the gas that the patient can actually inhale changes from M to m, which is less than N, and the gas flow required by the patient is insufficient. Therefore, at least during non-invasive ventilation, it is necessary to consider the factor of gas leakage to set the gas flow rate delivered, and the gas flow rate of the ventilation device set by the medical staff needs to be greater than the maximum gas flow rate required by the patient. In the following, the gas flow rate set by the ventilation device needs to be greater than the patient's peak inspiratory flow rate as an example for explanation.

[0032] The inventors have found in practice that it is not easy to determine the peak inspiratory flow of a patient receiving respiratory support. The peak inspiratory flow measured by a flowmeter or the like before the patient receives respiratory support is likely to be very different from the peak inspiratory flow of the patient when receiving respiratory support, so the best approach is to measure the patient's peak inspiratory flow while the patient is receiving respiratory support. The most important concept of the present application is that the gas flow required for inhalation by the patient can be obtained during a continuous respiratory support process, i.e., there is no need to interrupt the ventilation of the ventilation equipment, nor is there any need to reconnect the patient interface and the patient, so that the factors affecting the gas flow required for inhalation by the patient are minimized, and then the ventilation equipment can be more accurately set according to the gas flow required for inhalation by the patient.

[0033] It should also be noted that another significance of accurately measuring the gas flow rate that the patient needs to inhale during respiratory support is that the gas flow rate of the ventilation equipment does not need to be set too large. For example, when it is found that the currently set gas flow rate exceeds the gas flow rate that the patient needs to inhale too much, the gas flow rate of the ventilation equipment can be appropriately reduced to avoid the excessive gas flow from adversely affecting the patient's breathing.

[0034] Please refer to Figure 1 The ventilation device 100 shown is used to provide respiratory support for the patient. The ventilation device 100 may include but is not limited to a ventilator, an anesthesia machine, and an oxygen therapy device, etc. The respiratory support includes but is not limited to oxygen therapy. For example, the ventilation device 100 can perform (transnasal) high-flow oxygen therapy or other non-invasive ventilation therapy on the patient.

[0035] Specifically, the ventilation device 100 may include a gas source interface 110, a flow delivery device 120, a breathing circuit 130, a sensor 140, a memory 150, a human-computer interaction device 160, a processor 170 and a display device 180. It should be understood that Figure 1 The ventilation device 100 is merely an example and does not constitute a limitation on the ventilation device 100. When the ventilation device 100 is a specific type of instrument, it may include Figure 1 For example, when the ventilation device 100 is an oxygen therapy device that provides high-flow nasal oxygen therapy (HFNC, HFNC hereafter refers to high-flow nasal oxygen therapy) to the patient, the oxygen therapy device may also include a gas heating device and a gas humidification device. The breathing circuit 130 may be a single circuit or a double circuit (such as Figure 1 shown).

[0036] The gas source interface 110 is used to connect to a gas source (not shown in the figure), and the gas source is used to provide gas. The gas can generally be oxygen and air, etc. In some embodiments, the gas source can be a compressed gas cylinder or a central gas supply source, and the gas supply types include oxygen O2 and air, etc. In other embodiments, the gas source can also be a normal pressure gas, such as air in the external environment. That is, the ventilation device 100 can be a pneumatic, electric or gas-electric hybrid device. The gas source interface 110 may include conventional components such as a pressure gauge, a pressure regulator, a flow meter and a pressure reducing valve, which are respectively used to control the flow of various gases (such as oxygen and air). The gas input by the gas source interface 110 enters the flow transmission device 120 and the breathing circuit 130 and is used to output to the patient interface 131.

[0037] The flow delivery device 120 is used to drive the gas input from the gas source interface 110 to the patient's respiratory system at a specific flow rate. In a specific embodiment, the flow delivery device 120 generally includes a machine-controlled ventilation module, and the airflow pipeline of the machine-controlled ventilation module is connected to the breathing circuit 130. In some embodiments, the flow delivery device 120 also includes a turbine.

[0038] In the present application, the breathing circuit 130 may be a double-tube circuit, which includes an inhalation passage 130a and an exhalation passage 130b. The mixed gas of fresh air introduced by the gas source interface 110 is input from the inlet of the inhalation passage 130a, and is provided to the patient through the patient interface 131 provided at the outlet of the inhalation passage 130a. In other embodiments, the breathing circuit 130 may also be a single-tube circuit. For example, the patient interface 131 is a mask worn on the patient's face. The single-tube circuit delivers the breathing gas into the mask for the patient to inhale, and the gas exhaled by the patient is discharged directly through the mask or the exhalation valve. In addition, when the ventilation device 100 is an oxygen therapy device, the patient interface 131 may be a nasal catheter for inserting into the patient's nose.

[0039] The sensor 140 is used for real-time acquisition of the patient's physiological parameters during ventilation therapy and / or the ventilation parameters of the ventilation device 100. The sensor 140 may include one or more. The physiological parameters may include blood oxygen parameters and respiratory parameters accordingly, wherein the blood oxygen parameters include but are not limited to transcutaneous blood oxygen saturation (SpO2), arterial oxygen partial pressure (PaO2) and arterial oxygen saturation (SaO2), and the respiratory parameters may include but are not limited to inspired oxygen partial pressure (FiO2) and the patient's respiratory rate (RR). In some embodiments, the ventilation device 100 also includes a communication device 190, and the function of the communication device 190 is to receive the patient's blood oxygen parameters and respiratory parameters sent externally. That is to say, in this embodiment, the ventilation device 100 itself does not obtain the blood oxygen parameters and respiratory parameters to be processed later, but other medical devices obtain them and then send them to the ventilation device 100 for processing. In other embodiments, the sensor 140 and the communication device 190 can be combined. For example, the ventilation device 100 itself obtains the respiratory parameters in real time through the sensor 140, and receives the blood oxygen parameters sent externally through the communication device 190, and then processes the respiratory parameters and blood oxygen parameters.

[0040] In this embodiment, the sensor 140 includes a pressure sensor arranged at the first signal collection point 132a and a flow sensor arranged at the second signal collection point 132b. The pressure sensor is used to obtain pressure data of the first signal collection point 132a. The pressure data can represent the pressure value of the first signal collection point 132a. When the ventilation device 100 delivers different gas flow rates, the pressure data will also change accordingly. The flow sensor is used to obtain flow data of the second signal collection point 132b. The flow data can represent the flow value of the second signal collection point 132b. When the ventilation device 100 delivers different gas flow rates, the flow data will also change accordingly. The first signal collection point 132a and the second signal collection point 132b are both located between the gas source interface 110 and the patient interface 131 of the ventilation device 100. Figure 1 The positions of the first signal collection point 132a and the second signal collection point 132b are exemplarily marked, which does not represent the actual positions of the first signal collection point 132a and the second signal collection point 132b. It can be understood that the first signal collection point 132a and the second signal collection point 132b can be set at any place in the ventilation device 100 where flow data and pressure data can be collected, for example, they can be set in the flow delivery device 120, specifically between the turbine (if any) and the breathing tube 130, and can also be set in the breathing tube 130.

[0041] In some embodiments, the first signal collection point 132a and the second signal collection point 132b may also be the same signal collection point, that is, the pressure sensor and the flow sensor acquire data at the same signal collection point.

[0042] In some embodiments, the first signal collection point 132a and the second signal collection point 132b may be located inside the ventilation device 100. It is understood that the ventilation device 100 generally has a housing (not shown in the figure) for accommodating various functional components, and the first signal collection point 132a and the second signal collection point 132b are located inside the housing, that is, the pressure sensor and the flow sensor are disposed inside the housing.

[0043] The memory 150 may be used to store data or programs, for example, to store data collected by each sensor 140, data generated by the processor 170 through calculation, or an image frame generated by the processor 170, which may be a 2D or 3D image, or the memory 150 may store a graphical user interface, one or more default image display settings, or programming instructions for the processor 170. The memory 150 may be a tangible and non-transitory computer-readable medium, such as a flash memory, RAM, ROM, EEPROM, etc.

[0044] The ventilation device 100 may receive an input command signal through the human-computer interaction device 160, and the command signal may include ventilation mode control, ventilation parameter setting, etc. of the ventilation device 100. The human-computer interaction device 160 may include one or a combination of a keyboard, a mouse, a scroll wheel, and a mobile input device (a mobile device with a touch screen, a mobile phone, etc.), etc.

[0045] The processor 170 is used to execute instructions or programs, control the flow delivery device 120, the gas source interface 110 and / or various control valves in the breathing circuit 130, or process the received data to generate the required calculation or judgment results, or generate visual data or graphics, and output the visual data or graphics to the display device 180 for display.

[0046] The display device 180 is used to display the ventilation interface, on which part or all of at least one physiological parameter are displayed. The display device 180 may include one or more display screens, and each display screen may be a touch display screen or a non-touch display screen. When the display device 180 includes a touch display screen, the touch display screen may also serve as a part of the human-computer interaction device 160, and receive user instructions by responding to the user's touch operations.

[0047] In this embodiment, the gas flow rate set when the ventilation device 100 provides respiratory support to the patient or the theoretically output gas flow rate is defined as the second gas flow rate. For example, the medical staff sets the gas flow rate to 40 LPM on the operation panel of the oxygen therapy device, and the processor 170 controls the flow delivery device 120 to perform oxygen therapy for the patient at the second gas flow rate of 40 LPM. The key to this embodiment lies in how to determine the second gas flow rate, or what is used as a reference to determine the second gas flow rate.

[0048] To determine the second gas flow rate, the processor 170 controls the flow delivery device 120 to deliver gas to the patient interface 131 based on multiple first gas flow rates, and calculates the patient's flow characteristic parameters based on the pressure data and flow data under the multiple first gas flow rates. The flow characteristic parameters are related to the patient's physiological state and can be used as a reference for determining the second gas flow rate.

[0049] The first gas flow rate is also the gas flow rate theoretically output by the ventilation device 100. For example, the current gas flow rate displayed on the ventilation interface is 40 LPM, that is, the ventilation device 100 performs oxygen therapy for the patient at a second gas flow rate of 40 LPM, and then the ventilation device 100 delivers gas to the patient at a gas flow rate of 50 LPM and 60 LPM (the ventilation interface displays the gas flow rate as 50 LPM and 60 LPM, respectively), and calculates the flow characteristic parameters based on the pressure data and flow data under these two gas flow rates. In the above process, there are two first gas flow rates, 50 LPM and 60 LPM, respectively. In some embodiments, when the ventilation device provides respiratory support to the patient at the second gas flow rate, the processor 170 repeats the following steps at predetermined intervals: control the flow delivery device 120 to deliver gas to the patient interface 131 based on multiple first gas flow rates, and calculate the flow characteristic parameters based on the pressure data and flow data under multiple first gas flow rates. In other words, the ventilation device 100 periodically calculates the flow characteristic parameters by periodically delivering gas to the patient at multiple first gas flow rates.

[0050] Exemplarily, the second gas flow rate is 20LPM, the first gas flow rate is set to three and increases in intervals of 10LPM, the minimum first gas flow rate is set to be 10LPM greater than the second gas flow rate, and the predetermined duration is 2 minutes. After the ventilation device 100 provides respiratory support to the patient at a gas flow rate of 20LPM for 2 minutes, the ventilation device 100 delivers gas to the patient at gas flow rates of 30LPM, 40LPM and 50LPM in sequence, wherein each time the gas is delivered to the patient based on a first gas flow rate may include one or more respiratory cycles. The flow characteristic parameters can be calculated based on the pressure data and flow data under the above three first gas flow rates as a reference for determining the second gas flow rate. Assuming that after obtaining a flow characteristic parameter, the original second gas flow is changed from 20LPM to 30LPM according to the flow characteristic parameter, then after the ventilation device 100 provides respiratory support to the patient at a gas flow rate of 30LPM for 2 minutes, the ventilation device 100 delivers gas to the patient at gas flow rates of 40LPM, 50LPM and 60LPM in sequence, thus entering the next flow characteristic parameter calculation cycle.

[0051] The advantage of periodically performing ventilation with multiple first gas flow rates and calculating flow characteristic parameters is that a setting reference for the second gas flow rate can be obtained periodically.

[0052] It should be noted that the gas flow rate inhaled by the patient usually changes over time, that is, it changes dynamically. For example, the patient's physical condition may change at different times, and the inhaled gas flow rate may also change accordingly. The second gas flow rate desired by the medical staff should be close to or exceed the gas flow rate inhaled by the patient when the patient's flow characteristic parameters are calculated. For example, in the above example, the original second gas flow rate is changed from 20LPM to 30LPM according to the flow characteristic parameters because 30LPM is close to or exceeds the gas flow rate inhaled by the patient when the flow characteristic parameters are calculated. However, those skilled in the art will understand that since the gas flow rate inhaled by the patient changes dynamically, the calculation process can usually only ensure that the second gas flow rate is close to or exceeds the gas flow rate inhaled by the patient when the flow characteristic parameters are calculated in some embodiments, but it does not necessarily guarantee that it will always be close to or exceed the gas flow rate inhaled by the patient afterwards. In addition, the calculation of flow characteristic parameters should not be mechanically limited to the execution time of the "calculation" action. For example, in the above example, the ventilation device 100 periodically delivers gas to the patient at multiple first gas flow rates, and the flow characteristic parameters are calculated once in each cycle. The set second gas flow rate can be close to or exceed the gas flow rate inhaled by the patient at any time in the cycle. In the next cycle, the gas flow rate inhaled by the patient may be higher than the currently set second gas flow rate, or it may be lower than the currently set second gas flow rate. The second gas flow rate can be adjusted again according to the flow characteristic parameters calculated in the next cycle.

[0053] In some embodiments, during the process of the ventilation device 100 periodically delivering gas to the patient at multiple first gas flow rates, the multiple first gas flow rates do not change continuously or in a short period of time. After delivering gas to the patient at a first gas flow rate, the ventilation device 100 may deliver gas to the patient for a period of time based on the third gas flow rate, and then change to deliver gas to the patient at another first gas flow rate. Exemplarily, the second gas flow rate is 20LPM, the first gas flow rate is set to three and increases in intervals of 10LPM, the smallest first gas flow rate is set to be 10LPM greater than the third gas flow rate, and the predetermined duration is 2min. First, the ventilation device 100 delivers gas to the patient at a gas flow rate of 30LPM for 2min, and then the ventilation device 100 provides respiratory support to the patient at a gas flow rate of 20LPM for 2min. Then, after the ventilation device 100 delivers gas to the patient at a gas flow rate of 40LPM for 2min, the ventilation device 100 continues to provide respiratory support to the patient at a gas flow rate of 20LPM for 2min. Then, the ventilation device 100 delivers gas to the patient at a gas flow rate of 50 LPM for 2 minutes, and then the ventilation device 100 continues to provide respiratory support to the patient at a gas flow rate of 20 LPM. That is, in the process of delivering gas to the patient at multiple first gas flow rates to calculate the flow characteristic parameters, the process of ventilating at other flow rates that are irrelevant to the calculation of the flow characteristic parameters can be inserted, as long as it does not interfere with the delivery of gas to the patient at multiple first gas flow rates to calculate the flow characteristic parameters.

[0054] In some embodiments, the ventilation device 100 delivers gas to the patient at multiple first gas flow rates based on flow triggering. Specifically, when the flow delivery device 120 delivers gas to the patient interface 131 based on the second gas flow rate to provide respiratory support to the patient, the processor 170 compares the flow data acquired by the flow sensor with the fourth threshold range, and after identifying that the flow data exceeds the fourth threshold range, controls the flow delivery device 120 to deliver gas to the patient interface 131 based on the multiple first gas flow rates, and calculates the flow characteristic parameters based on the pressure data and flow data under the multiple first gas flow rates.

[0055] Exemplarily, the second gas flow rate is 20LPM, the first gas flow rate is set to three and increases in intervals of 10LPM, and the minimum first gas flow rate is set to be 10LPM greater than the second gas flow rate. In the process of the ventilation device 100 providing respiratory support to the patient at a gas flow rate of 20LPM, the processor 170 compares the flow data with the fourth threshold range. If the flow data exceeds the fourth threshold range, it means that the gas flow actually generated under the currently set second gas flow rate does not meet expectations. The ventilation device 100 delivers gas to the patient at gas flow rates of 30LPM, 40LPM and 50LPM in sequence, wherein each time the gas is delivered to the patient based on a first gas flow rate may include one or more breathing cycles. The flow characteristic parameter can be calculated based on the pressure data and flow data under the above three first gas flows as a reference for determining the second gas flow rate. For example, the second gas flow rate is reset based on the flow characteristic parameter so that the flow data is stabilized within the fourth threshold range again without being too large or too small. In some embodiments, the fourth threshold range can be updated as the second gas flow rate is updated. In other embodiments, the fourth threshold range can also be a fixed range.

[0056] The advantage of delivering gas to the patient at multiple first gas flow rates based on flow triggering is that the second gas flow rate can be adjusted or set for the purpose of stabilizing the flow rate to ensure that the gas flow actually generated at the second gas flow rate meets expectations.

[0057] In some embodiments, the ventilation device 100 delivers gas to the patient at multiple first gas flow rates based on pressure triggering. Specifically, when the flow delivery device 120 delivers gas to the patient interface 131 based on the second gas flow rate to provide respiratory support to the patient, the processor 170 compares the pressure data acquired by the pressure sensor with the fifth threshold range, and after identifying that the pressure data exceeds the fifth threshold range, controls the flow delivery device 120 to deliver gas to the patient interface 131 based on the multiple first gas flow rates, and calculates the flow characteristic parameters based on the pressure data and flow data under the multiple first gas flow rates.

[0058] Exemplarily, the second gas flow rate is 20LPM, the first gas flow rate is set to three and increases in intervals of 10LPM, and the minimum first gas flow rate is set to be 10LPM greater than the second gas flow rate. In the process of the ventilation device 100 providing respiratory support to the patient at a gas flow rate of 20LPM, the processor 170 compares the pressure data with the fifth threshold range. If the pressure data exceeds the fifth threshold range, it means that the actual gas pressure generated under the currently set second gas flow rate does not meet expectations. The ventilation device 100 delivers gas to the patient at gas flow rates of 30LPM, 40LPM and 50LPM in sequence, wherein each time the gas is delivered to the patient based on a first gas flow rate may include one or more breathing cycles. The flow characteristic parameter can be calculated based on the pressure data and flow data under the above three first gas flow rates as a reference for determining the second gas flow rate. For example, the second gas flow rate is reset based on the flow characteristic parameter so that the pressure data is stabilized within the fifth threshold range again without being too large or too small. In some embodiments, the fifth threshold range can be updated as the second gas flow rate is updated. In other embodiments, the fifth threshold range can also be a fixed range.

[0059] The advantage of delivering gas to the patient at multiple first gas flow rates based on pressure triggering is that the second gas flow rate can be adjusted or set for the purpose of stabilizing the pressure to ensure that the gas pressure actually generated at the second gas flow rate meets expectations.

[0060] In some embodiments, the ventilation device 100 has two ventilation stages, wherein the processor 170 controls the ventilation device 100 to deliver multiple first gas flow rates to the patient interface 131 in the first ventilation stage, and calculates the patient's flow characteristic parameters based on the pressure data and flow data under the multiple first gas flow rates. The processor 170 also controls the flow delivery device 120 to deliver gas to the patient interface 131 based on the second gas flow rate in the second ventilation stage to provide respiratory support to the patient.

[0061] Exemplarily, after the ventilation device 100 starts to provide respiratory support, it will first enter the first ventilation stage and then enter the second ventilation stage, and the first ventilation stage has three first gas flow rates by default, which are 20LPM, 30LPM and 40LPM. In the first ventilation stage, the ventilation device 100 delivers gas to the patient at gas flow rates of 20LPM, 30LPM and 40LPM in sequence, wherein the time for delivering gas to the patient based on a first gas flow rate each time may include one or more breathing cycles. Based on the pressure data and flow data under the above three first gas flow rates, the flow characteristic parameters can be calculated to serve as a reference for setting the second gas flow rate in the second ventilation stage. For example, after the flow characteristic parameters are calculated, the second gas flow rate in the second ventilation stage is finally set to 30LPM. It can also be seen from this embodiment that the second gas flow rate and one of the multiple first gas flow rates may also be the same.

[0062] It can be seen from the above description that in the process of providing respiratory support, the ventilation device 100 can "smoothly" transition to provide multiple first gas flow rates. The patient does not need to remove the mask or nasal catheter, nor does it need to temporarily stop delivering gas to the patient. The flow characteristic parameters used as a reference can be determined, thereby minimizing the impact of other factors on determining the gas flow that the patient needs to inhale.

[0063] The following further describes how to calculate the patient's flow characteristic parameters based on the pressure data and flow data at multiple first gas flow rates.

[0064] In some embodiments, during the process of the ventilation device 100 delivering gas to the patient at each first gas flow rate, the processor 170 calculates the proximal gas characteristics of the patient's proximal end at each first gas flow rate for a period of time based on the pressure data and flow data for a period of time at each first gas flow rate, and then determines the flow characteristic parameters based on the proximal gas characteristics. Among them, a period of time can be the total duration of ventilation with a first gas flow rate, for example, when gas is delivered to the patient at a first gas flow rate during i respiratory cycles of the patient, the proximal gas characteristics of the patient's proximal end during i respiratory cycles are calculated based on the pressure data and flow data during i respiratory cycles; a period of time can also be a part of the total duration of ventilation with a first gas flow rate, for example, when gas is delivered to the patient at a first gas flow rate during i respiratory cycles of the patient, the proximal gas characteristics corresponding to this part of the respiratory cycle are calculated based on the pressure data and flow data during a part of the respiratory cycle in i respiratory cycles.

[0065] In the above description of determining the flow characteristic parameters, the proximal gas characteristics of the patient's proximal end refer to the gas characteristics of the position close to the patient interface 131. The proximity here should not be understood mechanically. For those skilled in the art, the proximal end of the patient and the distal end of the patient are relative concepts. The position relatively close to the patient interface 131 can be understood as the proximal end of the patient. For example, when the ventilation device 100 is an oxygen therapy device, the oxygen therapy device itself can be used as the distal end of the patient. The pipeline between the oxygen therapy device and the nasal catheter and the nasal catheter itself can be understood as the proximal end of the patient, as long as it is closer to the patient than the first signal acquisition point 132a and the second signal acquisition point 132b. The gas characteristics refer to the characteristics or features that can reflect the flow and / or pressure. It can be seen from this that the process of delivering gas to the patient at multiple first gas flow rates to determine the flow characteristic parameters is actually to calculate the characteristics or features of the flow and / or pressure of the patient's proximal end through the actual pressure data and flow data when delivering gas to the patient at each first gas flow rate, and then determine the flow characteristic parameters according to the characteristics or features of the flow and / or pressure of the patient's proximal end.

[0066] It should be noted that the characteristics or features of the flow and / or pressure at the proximal end of the patient are calculated based on the pressure data of the first signal acquisition point 132a and the flow data of the second signal acquisition point 132b, rather than being directly measured at the proximal end of the patient. For example, when the proximal gas characteristic is the proximal pressure at the proximal end of the patient, it is not necessary to set up another pressure sensor at the proximal end of the patient to measure the proximal pressure. This is because the inventors have found that there are many problems with setting up another pressure sensor at the proximal end of the patient to measure the proximal pressure. First, there is not enough space to set up another pressure sensor near the patient interface 131; second, the closer some ventilation devices 100 are to the patient interface 131, the greater the impact on the measurement accuracy of the sensor; third, some ventilation devices 100 will replace the pipelines near the patient interface 131 more frequently, and the cost of setting up a pressure sensor will be higher.

[0067] The following uses the proximal gas characteristic as the proximal pressure as an example to further explain how to calculate the proximal pressure based on the pressure data and flow data in the technical solution of the present application.

[0068] In some embodiments, a model describing the relationship between pressure difference and flow data is first established. The pressure difference refers to the pressure difference between the first signal acquisition point 132a and the proximal end of the patient. The model can be a mathematical expression, a curve, a lookup table, or a machine learning model. The inventors have found that the above-mentioned pressure difference is related to the type and model of the respiratory circuit (ventilation circuit) and the nasal catheter, and has nothing to do with the air outlet gap of the patient interface 131. Since different types and models of ventilation circuits and nasal catheters have different resistance characteristics, an operation to obtain the above-mentioned functional relationship is required after operations such as replacing the nasal catheter. Specifically, the gas flow rate set by the ventilation device 100 can be gradually changed, and then the pressure data and flow data under different gas flow rates can be obtained, and the pressure value at the proximal end of the patient can be measured. A pressure difference can be obtained under each flow data, and then through methods such as Figure 2 The curve fitting method shown can express the relationship between the flow data and the pressure difference. From the above description, it can be seen that the process of establishing the model is somewhat similar to the process of obtaining the flow characteristic parameters. Both require the gas to be transported outward at different gas flow rates, but the two are completely different in essence. In the process of establishing the model, it is not necessary to connect to the patient's respiratory system. Therefore, an external pressure sensor can be used to measure the pressure value near the patient's proximal end. For example, a component with a pressure sensor at one end is extended into the patient interface 131 to measure the pressure near the patient interface 131. In some embodiments, the above model can be imported by an external device. In other embodiments, the above model can also be obtained in the ventilation device 100 through ventilation experiments.

[0069] In some embodiments, the preset model can be expressed as ΔP=f(Flow), and an exemplary specific expression is ΔP=K 1 *Flow, where Flow is the acquired flow data, and K1 is the coefficient obtained by fitting the pressure difference and flow data, then: P n = Press-ΔP = Press-K 1 *Flow, where Pn is the proximal pressure and Press is the pressure data. Substituting the collected pressure data and flow data into this formula, the proximal pressure can be calculated. Figure 3 The graph shows the change of pressure data, flow data and proximal pressure over time at a first gas flow rate. At the first gas flow rate, the patient has gone through multiple breathing cycles. From the graph, it can be seen that as the patient's breathing pressure data and flow data change, the calculated proximal pressure also changes accordingly. In addition to the above-mentioned expressions, other forms of polynomials, exponential functions, logarithmic functions, and power functions can also be used to represent the model. In some embodiments, the acquired model can also be stored in the ventilation device 100 in advance, and the user can set the type and model of the pipeline and nasal catheter on the operation interface to automatically match the corresponding model.

[0070] The above method for calculating the proximal pressure can reduce the interference of gas leakage at the patient interface 131, so that the obtained proximal pressure is more accurate.

[0071] As can be seen from the above description, the proximal gas characteristic is a value that changes with time. In some embodiments, according to the proximal gas characteristic that changes with time, a gas characteristic value corresponding to each first gas flow rate can be obtained, that is, a first gas flow rate has a gas characteristic value. After calculating the gas characteristic value under each first gas flow rate, the processor 170 uses the first gas flow rate corresponding to the gas characteristic value when the preset condition is met as the flow characteristic parameter. In other words, the ventilation device 100 delivers gas at multiple first gas flow rates and obtains the corresponding gas characteristic value. If there is a gas characteristic value under a certain first gas flow rate that meets the preset condition, the first gas flow rate is used as a reference for setting the second gas flow rate. The following continues to explain the proximal gas characteristic as the proximal pressure as an example. It can be understood that when the patient inhales, the inhalation flow rate will change, thereby causing the proximal pressure to change. When the same gas flow rate is used to deliver gas to the patient interface 131, the proximal pressure will decrease when the gas flow rate inhaled by the patient increases, and the proximal pressure will increase when the gas flow rate inhaled by the patient decreases.

[0072] In some embodiments, a statistical analysis is performed on the proximal pressure within a period of time under each first gas flow rate to obtain a pressure statistical value, and the pressure statistical value is used as a gas characteristic value. The pressure statistical value is any one of the mean value, standard deviation, median value, maximum value and minimum value. Then, it is determined whether the pressure statistical value falls within a preset first threshold range. If the pressure statistical value falls within the first threshold range, it means that the first gas flow rate corresponding to the pressure statistical value can be used as a reference for setting the second gas flow rate.

[0073] For example, Figure 4 In the figure, the first threshold range is the portion indicated by the dotted line, and the minimum value of the proximal pressure is taken as the pressure statistic value. When the first gas flow rate is 40 LPM, the minimum value of the proximal pressure falls within the first threshold range, so the flow characteristic parameter is 40 LPM.

[0074] In any breathing cycle, when the gas flow rate inhaled by the patient at the proximal end of the patient is the largest, the proximal pressure in the breathing cycle reaches a minimum value. Therefore, when the proximal pressure reaches a minimum value, it means that the gas flow rate inhaled by the patient is the peak inspiratory flow rate. If the minimum value of the proximal pressure is within the first threshold range, it means that the gas flow rate that can be provided at the proximal end of the patient under the current first gas flow rate is close to or exceeds the patient's peak inspiratory flow rate. Therefore, the first gas flow rate can be used as a reference for setting the second gas flow rate. For example, the second gas flow rate should not be less than the current first gas flow rate. The first threshold range can be obtained based on the clinical experience of medical staff or determined by other physiological parameters of the patient. For example, the first threshold range is a certain value of 0, which means that when delivering gas with multiple first gas flow rates, it is necessary to find a first gas flow rate: at this first gas flow rate, no negative pressure will be generated at the proximal end of the patient, that is, the gas flow rate at the proximal end of the patient ≥ gas leakage + inspiratory peak flow rate. This formula is also easy to understand. If the gas flow rate at the proximal end of the patient is less than the gas leakage + inspiratory peak flow rate, the patient not only needs to inhale gas from the breathing circuit, but also inhale gas from the outside, so that the proximal pressure will be less than 0; the first threshold range can also be obtained based on the positive end-expiratory pressure. For example, the first threshold range is between the patient's positive end-expiratory pressure and the sum of the positive end-expiratory pressure and a constant.

[0075] In some embodiments, when delivering gas at any first gas flow rate, the first duration of the first gas flow rate delivering gas to the patient interface 131 is recorded, and the second duration of the proximal pressure greater than the preset pressure threshold value in the first duration is recorded, and then the duration ratio between the second duration and the first duration is calculated as the gas characteristic value of the first gas flow rate. If the duration ratio falls within the preset second threshold range, it means that the time for the proximal pressure to be stable within a certain range is in line with expectations, and further means that the time for the proximal gas flow rate of the patient to be stable within a certain range is in line with expectations, for example, the time for approaching or exceeding the patient's inspiratory peak flow rate is in line with expectations, so the first gas flow rate corresponding to the time ratio can be used as a reference for setting the second gas flow rate.

[0076] In some embodiments, when gas is delivered at any first gas flow rate, an integral value of the proximal pressure over time during the patient's inhalation phase is obtained, and the integral value is used as a gas characteristic value. Figure 5, which is a graph showing the proximal pressure changing with time at a first gas flow rate, wherein the dotted line is the baseline, and the area enclosed by the proximal pressure change curve and the baseline is the integral value of the proximal pressure over time, which can represent the work done by the patient during the inhalation phase, wherein the baseline can be set by medical personnel based on the patient's condition, for example, the baseline is generated by the proximal pressure calculated when the ventilation device 100 has not yet started ventilation and the patient has not yet breathed after the patient interface 131 is connected to the patient, and the baseline represents the proximal pressure when the patient has not yet breathed and the ventilation device 100 has not yet ventilated. If the integral value falls within the preset third threshold range, it means that the work done by the patient during the inhalation phase is within a reasonable range, so the first gas flow rate corresponding to the integral value can be used as a reference for setting the second gas flow rate. Of course, the baseline can also be automatically set by the ventilation device 100.

[0077] In the above embodiment, the corresponding first gas flow whose gas characteristic value meets the preset conditions is taken as the flow characteristic parameter. In other embodiments, the flow characteristic parameter may not necessarily correspond to exactly one first gas flow. In this case, the first gas flow whose gas characteristic value meets the preset conditions may include more than one. Therefore, the flow characteristic parameter can be calculated based on the first gas flow corresponding to multiple gas characteristic values ​​that meet the preset conditions. For example, if the gas characteristic values ​​corresponding to n first gas flow rates all meet the preset conditions, then various fitting methods are used to obtain a gas flow as the flow characteristic parameter based on these n first gas flow rates.

[0078] For example, Figure 6 In the figure, the first threshold range is the dotted line part, the minimum value of the proximal pressure is taken as the pressure statistic value, and the minimum value of the proximal pressure when the first gas flow rate is 40LPM and when the first gas flow rate is 50LPM both fall within the first threshold range. Then, the average value of the two first gas flow rates can be taken as the flow characteristic parameter, or the two first gas flow rates can be multiplied by preset coefficients and then added to obtain the flow characteristic parameter.

[0079] In some embodiments, after obtaining the flow characteristic parameters, the ventilation device 100 automatically determines whether it is necessary to reset the second gas flow rate, and sets the second gas flow rate according to the flow characteristic parameters when it is necessary to reset, that is, obtaining the flow characteristic parameters does not mean that the second gas flow rate must be reset. For example, the current second gas flow rate is 30LPM, and then the gas characteristic value at 30LPM is obtained, and then the gas is delivered at the first gas flow rates of 40LPM and 50LPM respectively, and the gas characteristic values ​​at 40LPM and 50LPM are obtained respectively. Finally, after judgment, it is found that the gas characteristic value at 30LPM meets the preset conditions, then the current second gas flow rate does not need to be reset, and in this case, the second gas flow rate is equal to one of the multiple first gas flows.

[0080] In some embodiments, after obtaining a new flow characteristic parameter, the processor 170 compares the current flow characteristic parameter with the flow characteristic parameter obtained last time, and determines that the second gas flow rate needs to be reset when the flow characteristic parameter changes. For example, when the ventilation device 100 regularly delivers gas at multiple first gas flow rates, if the flow characteristic parameter obtained in the next cycle is the same as the flow characteristic parameter obtained in the previous cycle, it means that the reference for setting the second gas flow rate has not changed, and naturally there is no need to reset the second gas flow rate.

[0081] In some embodiments, the method of setting the second gas flow rate according to the flow characteristic parameter includes: obtaining a flow change value, and taking the sum of the flow characteristic parameter and the flow change value as the second gas flow rate, wherein the flow change value may be a preset constant, and the flow change value may be a positive value, and of course may also be 0. For example, the current second gas flow rate is 30LPM, the flow change value is 5LPM, and the flow characteristic parameter calculated after delivering gas at multiple first gas flow rates is 35LPM, then the processor 170 controls the gas flow delivered by the flow delivery device 120 to change from 30LPM to 40LPM.

[0082] In some embodiments, the method of setting the second gas flow rate according to the flow characteristic parameter includes: obtaining a proportional parameter, and taking the product of the flow characteristic parameter and the proportional parameter as the second gas flow rate. The proportional parameter may be a preset constant, and the proportional coefficient may be greater than or equal to 1. For example, the current second gas flow rate is 20 LPM, the proportional parameter is 1.2, and the flow characteristic parameter calculated after delivering gas at multiple first gas flow rates is 25 LPM, then the processor 170 controls the gas flow delivered by the flow delivery device 120 to change from 20 LPM to 30 LPM.

[0083] In addition to automatically setting the second gas flow rate, the user may be given the power to reset it.

[0084] In some embodiments, after the flow characteristic parameter is obtained, the flow characteristic parameter is displayed on the ventilation interface. The user can consider whether to reset the second gas flow rate according to the displayed flow characteristic parameter. If it is considered necessary to reset the second gas flow rate, the flow characteristic parameter can be used as a reference to determine whether to increase or decrease the second gas flow rate. In this process, the user can also make a decision based on other physiological parameters obtained. In some embodiments, the flow characteristic parameter can also be compared with a preset flow threshold range. If the flow characteristic parameter exceeds the flow threshold range, an alarm is issued. For example, when the flow characteristic parameter exceeds the upper limit of the flow threshold range, the user is prompted that the patient's inspiratory peak flow rate is too high and the currently set flow rate cannot meet the patient's inspiratory needs.

[0085] In some embodiments, information related to the flow characteristic parameter is output to prompt the user to set the second gas flow. For example, if the obtained flow characteristic parameter is higher than the current second gas flow, the user is prompted to appropriately increase the second gas flow. If the obtained flow characteristic parameter is less than the current second gas flow, the user is prompted to appropriately reduce the second gas flow. In addition, in addition to the adjustment direction, the prompt can also increase the adjustment amount. For example, when prompting the user to increase the current second gas flow, a suggestion on how much to increase can be given. When prompting the user to reduce the current second gas flow, a suggestion on how much to reduce can be given. For example, a dialog box can pop up, and when the user clicks to accept, the second gas flow is reset according to the suggestion in the dialog box. If the user does not accept, the current second gas flow is maintained for ventilation.

[0086] In some embodiments, after obtaining the flow characteristic parameter, the processor 170 compares the current flow characteristic parameter with the flow characteristic parameter obtained last time, and if the current flow characteristic parameter changes compared to the flow characteristic parameter obtained last time, information related to the changed flow characteristic parameter is output to prompt the user to increase or decrease the second gas flow rate. For example, when the ventilation device 100 regularly delivers gas at multiple first gas flow rates, if the flow characteristic parameter obtained in the next cycle increases compared to the flow characteristic parameter obtained in the previous cycle, information prompting the user to increase the second gas flow rate is output.

[0087] Please refer to Figure 7 The embodiment shown in the figure provides a method for regulating gas flow of a ventilation device, comprising:

[0088] Step S100: Obtain pressure data of the first signal collection point 132a.

[0089] Step S200: Acquire the flow data of the second signal collection point 132b.

[0090] The first signal collection point 132a and the second signal collection point 132b are both located between the air source interface of the ventilation device and the patient interface 131, the air source interface is used to connect the air source, and the patient interface 131 is used to connect the patient's respiratory system. The first signal collection point 132a and the second signal collection point 132b can be the same or different. Exemplarily, the first signal collection point 132a and the second signal collection point 132b can be inside the ventilation device 100 itself.

[0091] Step S300: delivering gas to the patient interface 131 based on a second gas flow rate to provide respiratory support to the patient, wherein the second gas flow rate approaches or exceeds the gas flow rate inhaled by the patient when the flow characteristic parameter of the patient is calculated.

[0092] It is understandable that the second gas flow rate desired by the medical staff should be close to or exceed the gas flow rate inhaled by the patient when the patient's flow characteristic parameters are calculated, so as to meet the patient's inhalation needs as much as possible.

[0093] Step S400: delivering gas to the patient interface 131 based on the multiple first gas flow rates, and calculating the patient's flow characteristic parameters according to the pressure data and flow data at the multiple first gas flow rates.

[0094] The flow characteristic parameters are related to the patient's physiological state and can be used as a reference for determining the second gas flow in step S300. The first gas flow here is the gas flow theoretically output by the ventilation device 100. For example, the current gas flow displayed on the ventilation interface is 40LPM, that is, the ventilation device 100 performs oxygen therapy for the patient at a second gas flow of 40LPM, and then the ventilation device 100 delivers gas to the patient at gas flow rates of 50LPM and 60LPM (the ventilation interface displays the gas flow rates as 50LPM and 60LPM, respectively), and calculates the flow characteristic parameters based on the pressure data and flow data under these two gas flow rates. In the above process, there are two first gas flow rates, namely 50LPM and 60LPM.

[0095] In some embodiments, gas is periodically delivered to the patient at multiple first gas flow rates to periodically calculate flow characteristic parameters, so step S400 is repeatedly executed at predetermined time intervals to repeatedly obtain flow characteristic parameters at predetermined time intervals.

[0096] Exemplarily, the second gas flow rate is 20LPM, the first gas flow rate is set to three and increases in intervals of 10LPM, the minimum first gas flow rate is set to be 10LPM greater than the second gas flow rate, and the predetermined duration is 2 minutes. After the ventilation device 100 provides respiratory support to the patient at a gas flow rate of 20LPM for 2 minutes, the ventilation device 100 delivers gas to the patient at gas flow rates of 30LPM, 40LPM and 50LPM in sequence, wherein each time the gas is delivered to the patient based on a first gas flow rate may include one or more respiratory cycles. The flow characteristic parameters can be calculated based on the pressure data and flow data under the above three first gas flow rates as a reference for determining the second gas flow rate. Assuming that after obtaining a flow characteristic parameter, the original second gas flow is changed from 20LPM to 30LPM according to the flow characteristic parameter, then after the ventilation device 100 provides respiratory support to the patient at a gas flow rate of 30LPM for 2 minutes, the ventilation device 100 delivers gas to the patient at gas flow rates of 40LPM, 50LPM and 60LPM in sequence, thus entering the next flow characteristic parameter calculation cycle.

[0097] In some embodiments, step S400 is triggered based on flow rate. Specifically, when delivering gas to the patient interface 131 based on the second gas flow rate to provide respiratory support to the patient, the acquired flow data is compared with the fourth threshold range, and after identifying that the flow data exceeds the fourth threshold range, step S400 is executed. In some embodiments, the fourth threshold range can be updated as the second gas flow rate is updated. In other embodiments, the fourth threshold range can also be a fixed range.

[0098] In some embodiments, step S400 is triggered based on pressure. Specifically, when delivering gas to the patient interface 131 based on the second gas flow rate to provide respiratory support to the patient, the acquired pressure data is compared with the fifth threshold range, and after identifying that the pressure data exceeds the fifth threshold range, step S400 is executed. In some embodiments, the fifth threshold range can be updated as the second gas flow rate is updated. In other embodiments, the fifth threshold range can also be a fixed range.

[0099] In some embodiments, the ventilation device 100 has two ventilation stages, wherein in the first ventilation stage, the ventilation device 100 delivers a plurality of first gas flow rates to the patient interface 131, and calculates the patient's flow characteristic parameters based on the pressure data and flow data under the plurality of first gas flow rates, and delivers gas to the patient interface 131 based on the second gas flow rate in the second ventilation stage to provide respiratory support to the patient, and the second gas flow rate in the second ventilation stage can be determined based on the flow characteristic parameters of the first ventilation stage. That is, firstly, step S400 is executed to calculate the flow characteristic parameters, and then step S300 is executed based on the calculated flow characteristic parameters.

[0100] Exemplarily, after the ventilation device 100 starts to provide respiratory support, it will first enter the first ventilation stage and then enter the second ventilation stage, and the first ventilation stage has three first gas flow rates by default, which are 20LPM, 30LPM and 40LPM. In the first ventilation stage, the ventilation device 100 delivers gas to the patient at gas flow rates of 20LPM, 30LPM and 40LPM in sequence, wherein the time for delivering gas to the patient based on a first gas flow rate each time may include one or more breathing cycles. Based on the pressure data and flow data under the above three first gas flow rates, the flow characteristic parameters can be calculated to serve as a reference for setting the second gas flow rate in the second ventilation stage. For example, after the flow characteristic parameters are calculated, the second gas flow rate in the second ventilation stage is finally set to 30LPM. It can also be seen from this embodiment that the second gas flow rate and one of the multiple first gas flow rates may also be the same.

[0101] The following further describes how to calculate the patient's flow characteristic parameters based on the pressure data and flow data at multiple first gas flow rates.

[0102] In some embodiments, during the process of the ventilation device 100 delivering gas to the patient at each first gas flow rate, the proximal gas characteristics of the patient's proximal end at each first gas flow rate for a period of time are calculated based on the pressure data and flow data for a period of time at each first gas flow rate, and then the flow characteristic parameters are determined based on the proximal gas characteristics. Among them, a period of time can be the total duration of ventilation with a first gas flow rate, for example, when gas is delivered to the patient at a first gas flow rate during i respiratory cycles of the patient, the proximal gas characteristics of the patient's proximal end during i respiratory cycles are calculated based on the pressure data and flow data during i respiratory cycles; a period of time can also be a part of the total duration of ventilation with a first gas flow rate, for example, when gas is delivered to the patient at a first gas flow rate during i respiratory cycles of the patient, the proximal gas characteristics corresponding to this part of the respiratory cycle are calculated based on the pressure data and flow data during a part of the respiratory cycle in i respiratory cycles.

[0103] In the above description of determining the flow characteristic parameters, the proximal gas characteristics of the patient's proximal end refer to the gas characteristics of the position close to the patient interface 131. The proximity here should not be understood mechanically. For those skilled in the art, the proximal end of the patient and the distal end of the patient are relative concepts. The position relatively close to the patient interface 131 can be understood as the proximal end of the patient. The proximal end of the patient only needs to be closer to the patient than the first signal acquisition point 132a and the second signal acquisition point 132b. The gas characteristics refer to the characteristics or features that can reflect the flow and / or pressure. It can be seen from this that the process of delivering gas to the patient at multiple first gas flow rates to determine the flow characteristic parameters is actually to calculate the characteristics or features of the flow and / or pressure at the proximal end of the patient through the actual pressure data and flow data when delivering gas to the patient at each first gas flow rate, and then determine the flow characteristic parameters according to the characteristics or features of the flow and / or pressure at the proximal end of the patient.

[0104] The following uses the proximal gas characteristic as the proximal pressure as an example to further explain how to calculate the proximal pressure based on the pressure data and flow data in the technical solution of the present application.

[0105] In some embodiments, a model describing the relationship between pressure difference and flow data is first established. The pressure difference refers to the pressure difference between the first signal acquisition point 132a and the proximal end of the patient. The model can be a mathematical expression, a curve, a lookup table, or a machine learning model. The inventors have found that the above-mentioned pressure difference is related to the type and model of the respiratory circuit (ventilation circuit) and the nasal catheter, and has nothing to do with the air outlet gap of the patient interface 131. Since different types and models of ventilation circuits and nasal catheters have different resistance characteristics, an operation to obtain the above-mentioned functional relationship is required after operations such as replacing the nasal catheter. Specifically, the gas flow rate set by the ventilation device 100 can be gradually changed, and then the pressure data and flow data under different gas flow rates can be obtained, and the pressure value at the proximal end of the patient can be measured. A pressure difference can be obtained under each flow data, and then through methods such as Figure 2 The curve fitting method shown can express the relationship between the flow data and the pressure difference. From the above description, it can be seen that the process of establishing the model is somewhat similar to the process of obtaining the flow characteristic parameters. Both require the gas to be transported outward at different gas flow rates, but the two are completely different in essence. In the process of establishing the model, it is not necessary to connect to the patient's respiratory system. Therefore, an external pressure sensor can be used to measure the pressure value near the patient's proximal end. For example, a component with a pressure sensor at one end is extended into the patient interface 131 to measure the pressure near the patient interface 131. In some embodiments, the above model can be imported by an external device. In other embodiments, the above model can also be obtained in the ventilation device 100 through ventilation experiments.

[0106] In some embodiments, the preset model can be expressed as ΔP=f(Flow), and an exemplary specific expression is ΔP=K 1 *Flow, where Flow is the acquired flow data, and K1 is the coefficient obtained by fitting the pressure difference and flow data, then: P n = Press-ΔP = Press-K 1 *Flow, where Pn is the proximal pressure and Press is the pressure data. Substituting the collected pressure data and flow data into this formula, the proximal pressure can be calculated. Figure 3 The graph shows the change of pressure data, flow data and proximal pressure over time at a first gas flow rate. At the first gas flow rate, the patient has gone through multiple breathing cycles. From the graph, it can be seen that as the patient's breathing pressure data and flow data change, the calculated proximal pressure also changes accordingly. In addition to the above-mentioned expressions, other forms of polynomials, exponential functions, logarithmic functions, and power functions can also be used to represent the model. In some embodiments, the acquired model can also be stored in the ventilation device 100 in advance, and the user can set the type and model of the pipeline and nasal catheter on the operation interface to automatically match the corresponding model.

[0107] It can be seen from the above description that the proximal gas characteristic is a value that changes with time. In some embodiments, according to the proximal gas characteristic that changes with time, a gas characteristic value corresponding to each first gas flow rate can be obtained, that is, a first gas flow rate has a gas characteristic value. After calculating the gas characteristic value under each first gas flow rate, the first gas flow rate corresponding to the gas characteristic value when the preset condition is met is used as the flow characteristic parameter. In other words, the ventilation device 100 delivers gas at multiple first gas flow rates and obtains the corresponding gas characteristic value. If there is a gas characteristic value under a certain first gas flow rate that meets the preset condition, the first gas flow rate is used as a reference for setting the second gas flow rate. The following continues to explain the proximal gas characteristic as the proximal pressure as an example. It can be understood that when the patient inhales, the inhalation flow rate will change, thereby causing the proximal pressure to change. When the same gas flow rate is used to deliver gas to the patient interface 131, the proximal pressure will decrease when the gas flow rate inhaled by the patient increases, and the proximal pressure will increase when the gas flow rate inhaled by the patient decreases.

[0108] In some embodiments, a statistical analysis is performed on the proximal pressure within a period of time under each first gas flow rate to obtain a pressure statistical value, and the pressure statistical value is used as a gas characteristic value. The pressure statistical value is any one of the mean value, standard deviation, median value, maximum value and minimum value. Then, it is determined whether the pressure statistical value falls within a preset first threshold range. If the pressure statistical value falls within the first threshold range, it means that the first gas flow rate corresponding to the pressure statistical value can be used as a reference for setting the second gas flow rate.

[0109] For example, Figure 4 In the figure, the first threshold range is the portion indicated by the dotted line, and the minimum value of the proximal pressure is taken as the pressure statistic value. When the first gas flow rate is 40 LPM, the minimum value of the proximal pressure falls within the first threshold range, so the flow characteristic parameter is 40 LPM.

[0110] In any breathing cycle, when the gas flow rate inhaled by the patient at the proximal end of the patient is the largest, the proximal pressure in the breathing cycle reaches a minimum value. Therefore, when the proximal pressure reaches a minimum value, it means that the gas flow rate inhaled by the patient is the peak inspiratory flow rate. If the minimum value of the proximal pressure is within the first threshold range, it means that the gas flow rate that can be provided at the proximal end of the patient under the current first gas flow rate is close to or exceeds the patient's peak inspiratory flow rate. Therefore, the first gas flow rate can be used as a reference for setting the second gas flow rate. For example, the second gas flow rate should not be less than the current first gas flow rate. The first threshold range can be obtained based on the clinical experience of medical staff or determined by other physiological parameters of the patient. For example, the first threshold range is a certain value of 0, which means that when delivering gas with multiple first gas flow rates, it is necessary to find a first gas flow rate: at this first gas flow rate, no negative pressure will be generated at the proximal end of the patient, that is, the gas flow rate at the proximal end of the patient ≥ gas leakage + inspiratory peak flow rate. This formula is also easy to understand. If the gas flow rate at the proximal end of the patient is less than the gas leakage + inspiratory peak flow rate, the patient not only needs to inhale gas from the breathing circuit, but also inhale gas from the outside, so that the proximal pressure will be less than 0; the first threshold range can also be obtained based on the positive end-expiratory pressure. For example, the first threshold range is between the patient's positive end-expiratory pressure and the sum of the positive end-expiratory pressure and a constant.

[0111] In some embodiments, when delivering gas at any first gas flow rate, the first duration of the first gas flow rate delivering gas to the patient interface 131 is recorded, and the second duration of the proximal pressure greater than the preset pressure threshold value in the first duration is recorded, and then the duration ratio between the second duration and the first duration is calculated as the gas characteristic value of the first gas flow rate. If the duration ratio falls within the preset second threshold range, it means that the time for the proximal pressure to be stable within a certain range is in line with expectations, and further means that the time for the proximal gas flow rate of the patient to be stable within a certain range is in line with expectations, for example, the time for approaching or exceeding the patient's inspiratory peak flow rate is in line with expectations, so the first gas flow rate corresponding to the time ratio can be used as a reference for setting the second gas flow rate.

[0112] In some embodiments, when gas is delivered at any first gas flow rate, an integral value of the proximal pressure over time during the patient's inhalation phase is obtained, and the integral value is used as a gas characteristic value. Figure 5, which is a graph showing the proximal pressure changing with time at a first gas flow rate, wherein the dotted line is the baseline, and the area enclosed by the proximal pressure change curve and the baseline is the integral value of the proximal pressure over time, which can represent the work done by the patient during the inhalation phase, wherein the baseline can be set by medical personnel based on the patient's condition, for example, the baseline is generated by the proximal pressure calculated when the ventilation device 100 has not yet started ventilation and the patient has not yet breathed after the patient interface 131 is connected to the patient, and the baseline represents the proximal pressure when the patient has not yet breathed and the ventilation device 100 has not yet ventilated. If the integral value falls within the preset third threshold range, it means that the work done by the patient during the inhalation phase is within a reasonable range, so the first gas flow rate corresponding to the integral value can be used as a reference for setting the second gas flow rate. Of course, the baseline can also be automatically set by the ventilation device 100.

[0113] In the above embodiment, the corresponding first gas flow whose gas characteristic value meets the preset conditions is taken as the flow characteristic parameter. In other embodiments, the flow characteristic parameter may not necessarily correspond to exactly one first gas flow. In this case, the first gas flow whose gas characteristic value meets the preset conditions may include more than one. Therefore, the flow characteristic parameter can be calculated based on the first gas flow corresponding to multiple gas characteristic values ​​that meet the preset conditions. For example, if the gas characteristic values ​​corresponding to n first gas flow rates all meet the preset conditions, then various fitting methods are used to obtain a gas flow as the flow characteristic parameter based on these n first gas flow rates.

[0114] For example, Figure 6 In the figure, the first threshold range is the dotted line part, the minimum value of the proximal pressure is taken as the pressure statistic value, and the minimum value of the proximal pressure when the first gas flow rate is 40LPM and when the first gas flow rate is 50LPM both fall within the first threshold range. Then, the average value of the two first gas flow rates can be taken as the flow characteristic parameter, or the two first gas flow rates can be multiplied by preset coefficients and then added to obtain the flow characteristic parameter.

[0115] In some embodiments, after step S400, the method further includes:

[0116] Step S500, determine whether it is necessary to reset the second gas flow rate, if it is necessary to reset the gas flow rate, execute step S600, otherwise, continue to execute step S300.

[0117] As can be seen from step S500, obtaining the flow characteristic parameter does not mean that the second gas flow must be reset. For example, the current second gas flow is 30 LPM, then the gas characteristic value at 30 LPM is obtained, and then the gas is delivered at the first gas flow of 40 LPM and 50 LPM respectively, and the gas characteristic values ​​at 40 LPM and 50 LPM are obtained respectively. Finally, after judgment, it is found that the gas characteristic value at 30 LPM meets the preset conditions, then the current second gas flow does not need to be reset, and in this case, the second gas flow is equal to one of the multiple first gas flows.

[0118] In some embodiments, after a new flow characteristic parameter is obtained, the current newly obtained flow characteristic parameter is compared with the flow characteristic parameter obtained last time, and it is determined that the second gas flow rate needs to be reset when the flow characteristic parameter changes. For example, when the ventilation device 100 regularly delivers gas at multiple first gas flow rates, if the flow characteristic parameter obtained in the next cycle is the same as the flow characteristic parameter obtained in the previous cycle, it means that the reference for setting the second gas flow rate has not changed, and naturally there is no need to reset the second gas flow rate.

[0119] Step S600: setting the second gas flow rate according to the flow characteristic parameters.

[0120] In some embodiments, the method of setting the second gas flow rate according to the flow characteristic parameter includes: obtaining a flow change value, and taking the sum of the flow characteristic parameter and the flow change value as the second gas flow rate, wherein the flow change value may be a preset constant, and the flow change value may be a positive value, and of course may also be 0. For example, the current second gas flow rate is 30LPM, the flow change value is 5LPM, and the flow characteristic parameter calculated after delivering gas at multiple first gas flow rates is 35LPM, then the delivered gas flow rate is changed from 30LPM to 40LPM.

[0121] In some embodiments, the method of setting the second gas flow rate according to the flow characteristic parameter includes: obtaining a proportional parameter, and taking the product of the flow characteristic parameter and the proportional parameter as the second gas flow rate. The proportional parameter may be a preset constant, and the proportional coefficient may be greater than 1 or equal to 1. For example, if the current second gas flow rate is 20 LPM, the proportional parameter is 1.2, and the flow characteristic parameter calculated after delivering gas at multiple first gas flow rates is 25 LPM, the delivered gas flow rate is changed from 20 LPM to 30 LPM.

[0122] In some embodiments, after the flow characteristic parameters are obtained, step S500 is not performed, but the power of resetting the second gas flow rate is given to the user.

[0123] In some embodiments, after the flow characteristic parameters are obtained, the flow characteristic parameters are displayed on the ventilation interface. The user can consider whether to reset the second gas flow based on the displayed flow characteristic parameters. If it is considered necessary to reset the second gas flow, the flow characteristic parameters can be used as a reference to determine whether to increase or decrease the second gas flow. In this process, the user can also make a decision based on other physiological parameters obtained.

[0124] In some embodiments, information related to the flow characteristic parameter is output to prompt the user to set the second gas flow. For example, if the obtained flow characteristic parameter is higher than the current second gas flow, the user is prompted to appropriately increase the second gas flow, and if the obtained flow characteristic parameter is lower than the current second gas flow, the user is prompted to appropriately reduce the second gas flow. In addition, in addition to the adjustment direction, the prompt can also increase the adjustment amount. For example, when prompting the user to increase the current second gas flow, a suggestion on how much to increase can be given, and when prompting the user to reduce the current second gas flow, a suggestion on how much to reduce can be given.

[0125] In some embodiments, after the flow characteristic parameter is obtained, the current flow characteristic parameter is compared with the flow characteristic parameter obtained last time, and if the current flow characteristic parameter is changed compared with the flow characteristic parameter obtained last time, information related to the changed flow characteristic parameter is output to prompt the user to increase or decrease the second gas flow rate. For example, when the ventilation device 100 regularly delivers gas at multiple first gas flow rates, if the flow characteristic parameter obtained in the next cycle increases compared with the flow characteristic parameter obtained in the previous cycle, information prompting the user to increase the second gas flow rate is output.

[0126] According to the ventilation equipment and gas flow regulation method thereof in the above-mentioned embodiments, the gas flow that the patient needs to inhale can be determined more accurately, thereby ensuring the patient's inhalation requirements. For example, the patient's peak inhalation flow can be calculated while the patient is receiving respiratory support, and the second gas flow can be determined based on the peak inhalation flow, thereby ensuring the effect of respiratory support.

[0127] This document is described with reference to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope of this document. For example, various operating steps and components for performing the operating steps may be implemented in different ways (e.g., one or more steps may be deleted, modified, or incorporated into other steps) depending on the specific application or considering any number of cost functions associated with the operation of the system.

[0128] In addition, as will be appreciated by those skilled in the art, the principles of the present invention may be reflected in a computer program product on a computer-readable storage medium, which is pre-installed with a computer-readable program code. Any tangible, non-temporary computer-readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROMs, DVDs, Blu Ray disks, etc.), flash memory, and / or the like. These computer program instructions may be loaded onto a general-purpose computer, a special-purpose computer, or other programmable data processing device to form a machine, so that these instructions executed on a computer or other programmable data processing device may generate a device that implements a specified function. These computer program instructions may also be stored in a computer-readable memory, which may instruct a computer or other programmable data processing device to operate in a specific manner, so that the instructions stored in the computer-readable memory may form a manufactured product, including an implementation device that implements a specified function. The computer program instructions may also be loaded onto a computer or other programmable data processing device, so that a series of operating steps are performed on the computer or other programmable device to produce a computer-implemented process, so that the instructions executed on the computer or other programmable device may provide steps for implementing a specified function.

[0129] Although the principles of this invention have been shown in various embodiments, many modifications of structures, arrangements, proportions, elements, materials and components particularly suitable for specific environments and operational requirements can be used without departing from the principles and scope of this invention. The above modifications and other changes or amendments will be included in the scope of this invention.

[0130] The foregoing specific description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes can be made without departing from the scope of the present disclosure. Therefore, the consideration of the present disclosure will be illustrative rather than restrictive, and all these modifications will be included in its scope. Similarly, the advantages, other advantages and solutions to the problems of various embodiments have been described above. However, the benefits, advantages, solutions to the problems and any elements that can produce these, or make them more clear, should not be interpreted as critical, necessary or necessary. The term "include" and any other variants used in this article are all non-exclusive inclusions, so that the process, method, article or device including the list of elements not only includes these elements, but also includes other elements that are not explicitly listed or do not belong to the process, method, system, article or device. In addition, the term "coupled" and any other variants used in this article refer to physical connections, electrical connections, magnetic connections, optical connections, communication connections, functional connections and / or any other connections.

[0131] Those skilled in the art will appreciate that many changes may be made to the details of the above-described embodiments without departing from the basic principles of the invention. Therefore, the scope of the invention should be determined from the following claims.

Claims

1. A ventilation device, characterized in that: include: Gas source interface, used to connect the gas source; A patient interface, used to connect to the patient's breathing system; a flow delivery device for delivering gas to the patient interface; A pressure sensor, used to obtain pressure data of a first signal collection point; A flow sensor, used to obtain flow data of a second signal collection point, wherein the first signal collection point and the second signal collection point are both located between the air source interface of the ventilation device and the patient interface; a processor, configured to control the flow delivery device to deliver gas to the patient interface based on a plurality of first gas flow rates, and to calculate a flow characteristic parameter of the patient based on the pressure data and the flow data under the plurality of first gas flow rates; and for controlling the flow delivery device to deliver gas to the patient interface based on a second gas flow rate to provide respiratory support to the patient, wherein the second gas flow rate approaches or exceeds the gas flow rate inhaled by the patient when the flow characteristic parameter of the patient is calculated; The flow characteristic parameter is related to the physiological state of the patient and is used as a reference for determining the second gas flow.

2. The ventilation device according to claim 1, characterized in that The step of calculating the flow characteristic parameters of the patient according to the pressure data and the flow data under the plurality of first gas flow rates comprises: According to the pressure data and the flow data under the multiple first gas flow rates, the proximal gas characteristics of the patient's proximal end under the multiple first gas flow rates are calculated, and the flow characteristic parameters are determined based on the proximal gas characteristics; the proximal end of the patient is closer to the patient than the first signal acquisition point and the second signal acquisition point.

3. The ventilation device according to claim 2, characterized in that The calculating, according to the pressure data and the flow data at the multiple first gas flow rates, the proximal gas characteristics of the patient's proximal end at the multiple first gas flow rates, and determining the flow characteristic parameter based on the proximal gas characteristics, comprises: Calculate the gas characteristics of the proximal end of the patient at each first gas flow rate for a period of time according to the pressure data and the flow data at each first gas flow rate for a period of time; The flow characteristic parameter is determined according to the proximal gas characteristics within a period of time under the multiple first gas flow rates.

4. The ventilation device according to claim 3, characterized in that The calculating of the gas characteristics of the proximal end of the patient at each of the first gas flow rates for a period of time includes: The pressure data and the flow data within a period of time at each of the first gas flow rates are input into a preset model, and the proximal pressure of the patient's proximal end within a period of time at each of the first gas flow rates is calculated, and the proximal pressure is used as the proximal gas characteristic.

5. The ventilation device according to claim 4, characterized in that The determining the flow characteristic parameter according to the proximal gas characteristics within a period of time under the multiple first gas flow rates includes: According to the proximal gas characteristics within a period of time at each of the first gas flow rates, a corresponding gas characteristic value at each of the first gas flow rates is calculated; Determine whether the gas characteristic value meets the preset conditions, and use the first gas flow corresponding to the gas characteristic value that meets the preset conditions as the flow characteristic parameter; or, calculate the flow characteristic parameter based on the first gas flow corresponding to multiple gas characteristic values ​​that meet the preset conditions.

6. The ventilation device according to claim 5, characterized in that The calculating, according to the proximal gas characteristics within a period of time at each of the first gas flow rates, a corresponding gas characteristic value at each of the first gas flow rates, comprises: A statistical analysis is performed on the proximal pressure within a period of time at each of the first gas flows to obtain a pressure statistic value, and the pressure statistic value is used as the gas characteristic value. The pressure statistic value is any one of a mean value, a standard deviation, a median, a maximum value and a minimum value.

7. The ventilation device according to claim 6, characterized in that The determining whether the gas characteristic value meets a preset condition includes: It is determined whether the pressure statistic falls within a preset first threshold range.

8. The ventilation device according to claim 5, characterized in that The calculating, according to the proximal gas characteristics within a period of time at each of the first gas flow rates, a corresponding gas characteristic value at each of the first gas flow rates, comprises: recording a first duration when the flow delivery device delivers gas to the patient interface based on each of the first gas flows; Recording a second time duration during which the proximal pressure is greater than a preset pressure threshold when the flow delivery device delivers gas to the patient interface based on each of the first gas flows; The time ratio between the second time period and the first time period is used as the gas characteristic value.

9. The ventilation device according to claim 8, characterized in that The determining whether the gas characteristic value meets a preset condition includes: It is determined whether the duration ratio falls within a preset second threshold range.

10. The ventilation device according to claim 5, characterized in that The calculating, according to the proximal gas characteristics within a period of time at each of the first gas flow rates, a corresponding gas characteristic value at each of the first gas flow rates, comprises: The integral value of the proximal pressure over time during the inhalation phase of the patient when the flow delivery device delivers gas to the patient interface based on each first gas flow rate is obtained, and the integral value is used as the gas characteristic value.

11. The ventilation device according to claim 10, characterized in that The determining whether the gas characteristic value meets a preset condition includes: It is determined whether the integral value falls within a preset third threshold range.

12. The ventilation device according to claim 1, characterized in that The processor is used to repeatedly execute the following steps at predetermined time intervals: control the flow delivery device to deliver gas to the patient interface based on the multiple first gas flow rates, and calculate the flow characteristic parameters based on the pressure data and the flow data under the multiple first gas flow rates.

13. The ventilation device according to claim 1, characterized in that The controlling the flow delivery device to deliver gas to the patient interface based on the multiple first gas flow rates, and calculating the flow characteristic parameter according to the pressure data and the flow data under the multiple first gas flow rates, includes: When the flow delivery device delivers gas to the patient interface based on the second gas flow rate to provide respiratory support to the patient, the flow data is compared with a fourth threshold range. After identifying that the flow data exceeds the fourth threshold range, the flow delivery device is controlled to deliver gas to the patient interface based on the multiple first gas flow rates, and the flow characteristic parameters are calculated based on the pressure data and the flow data under the multiple first gas flow rates.

14. The ventilation device according to claim 1, characterized in that The controlling the flow delivery device to deliver gas to the patient interface based on the multiple first gas flow rates, and calculating the flow characteristic parameter according to the pressure data and the flow data under the multiple first gas flow rates, includes: When the flow delivery device delivers gas to the patient interface based on the second gas flow rate to provide respiratory support to the patient, the pressure data is compared with a fifth threshold range. After identifying that the pressure data exceeds the fifth threshold range, the flow delivery device is controlled to deliver gas to the patient interface based on the multiple first gas flow rates, and the flow characteristic parameters are calculated based on the pressure data and the flow data under the multiple first gas flow rates.

15. The ventilation device according to any one of claims 1 to 14, characterized in that The processor is further configured to: The second gas flow rate is set according to the flow characteristic parameter.

16. The ventilation device according to claim 15, characterized in that The step of setting the second gas flow rate according to the flow characteristic parameter comprises: A flow rate change value is obtained, and the sum of the flow rate characteristic parameter and the flow rate change value is used as the second gas flow rate.

17. The ventilation device of claim 15, wherein: The step of setting the second gas flow rate according to the flow characteristic parameter comprises: A proportional parameter is obtained, and a product of the flow characteristic parameter and the proportional parameter is used as the second gas flow rate.

18. The ventilation device of claim 15, wherein: The step of setting the second gas flow rate according to the flow characteristic parameter comprises: After identifying that the flow characteristic parameter has changed, the second gas flow rate is set according to the changed flow characteristic parameter.

19. The ventilation device of claim 1, wherein: The flow characteristic parameter is used as a reference for determining the flow rate of the second gas, including at least one of the following methods: Displaying the flow characteristic parameters; Outputting information related to the flow characteristic parameter to prompt a user to set the second gas flow rate; After identifying that the flow characteristic parameter has changed, information related to the changed flow characteristic parameter is output to prompt the user to increase or decrease the second gas flow.

20. The ventilation device of claim 1, wherein: The processor is used to control the ventilation device to deliver a plurality of first gas flow rates to the patient interface in a first ventilation stage, and calculate the patient's flow characteristic parameters according to the pressure data and the flow data under the plurality of first gas flow rates; And in the second ventilation stage, the flow delivery device is used to control the flow delivery device to deliver gas to the patient interface based on the second gas flow rate to provide respiratory support to the patient.

21. The ventilation device of claim 1, wherein: It also includes a shell, in which the processor, the pressure sensor and the flow sensor are all arranged.

22. A method for regulating gas flow of a ventilation device, characterized in that: include: Acquire pressure data of a first signal collection point; Acquire flow data of a second signal collection point, wherein the first signal collection point and the second signal collection point are both located between an air source interface and a patient interface of the ventilation device, the air source interface is used to connect to an air source, and the patient interface is used to connect to a respiratory system of a patient; Delivering gas to the patient interface based on a second gas flow rate to provide respiratory support to the patient, wherein the second gas flow rate approaches or exceeds the gas flow rate inhaled by the patient when the patient's flow characteristic parameter is calculated; Based on multiple first gas flow rates, gas is delivered to the patient interface, and the patient's flow characteristic parameters are calculated according to the pressure data and the flow data under the multiple first gas flow rates, wherein the flow characteristic parameters are related to the patient's physiological state and are used as a reference for determining the second gas flow rate.

23. The method of claim 22, wherein: The step of calculating the flow characteristic parameters of the patient according to the pressure data and the flow data under the plurality of first gas flow rates comprises: According to the pressure data and the flow data under the multiple first gas flow rates, the proximal gas characteristics of the patient's proximal end under the multiple first gas flow rates are calculated, and the flow characteristic parameters are determined based on the proximal gas characteristics; the proximal end of the patient is closer to the patient than the first signal acquisition point and the second signal acquisition point.

24. The method of claim 23, wherein: The calculating, according to the pressure data and the flow data at the multiple first gas flow rates, the proximal gas characteristics of the patient's proximal end at the multiple first gas flow rates, and determining the flow characteristic parameter based on the proximal gas characteristics, comprises: Calculate the gas characteristics of the proximal end of the patient at each first gas flow rate for a period of time according to the pressure data and the flow data at each first gas flow rate for a period of time; The flow characteristic parameter is determined according to the proximal gas characteristics within a period of time under the multiple first gas flow rates.

25. The method of claim 24, wherein: The calculating of the gas characteristics of the proximal end of the patient at each of the first gas flow rates for a period of time includes: The pressure data and the flow data within a period of time at each of the first gas flow rates are input into a preset model, and the proximal pressure of the patient's proximal end within a period of time at each of the first gas flow rates is calculated, and the proximal pressure is used as the proximal gas characteristic.

26. The method of claim 25, wherein: The determining the flow characteristic parameter according to the proximal gas characteristics within a period of time under the multiple first gas flow rates includes: According to the proximal gas characteristics within a period of time at each of the first gas flow rates, a corresponding gas characteristic value at each of the first gas flow rates is calculated; Determine whether the gas characteristic value meets the preset conditions, and use the first gas flow corresponding to the gas characteristic value that meets the preset conditions as the flow characteristic parameter; or, calculate the flow characteristic parameter based on the first gas flow corresponding to multiple gas characteristic values ​​that meet the preset conditions.

27. The method of claim 22, wherein: Also includes: The following steps are repeatedly performed at predetermined time intervals: delivering gas to the patient interface based on the multiple first gas flow rates, and calculating the flow characteristic parameters according to the pressure data and the flow data under the multiple first gas flow rates.

28. The method of claim 22, wherein: The delivering gas to the patient interface based on the multiple first gas flow rates, and calculating the flow characteristic parameter according to the pressure data and the flow data under the multiple first gas flow rates, comprises: When delivering gas to the patient interface based on the second gas flow rate to provide respiratory support to the patient, the flow data is compared with a fourth threshold range. After identifying that the flow data exceeds the fourth threshold range, gas is delivered to the patient interface based on the multiple first gas flow rates, and the flow characteristic parameters are calculated based on the pressure data and the flow data under the multiple first gas flow rates.

29. The method of claim 22, wherein: The delivering gas to the patient interface based on the multiple first gas flow rates, and calculating the flow characteristic parameter according to the pressure data and the flow data under the multiple first gas flow rates, comprises: When delivering gas to the patient interface based on the second gas flow rate to provide respiratory support to the patient, the pressure data is compared with the fifth threshold range. After identifying that the pressure data exceeds the fifth threshold range, gas is delivered to the patient interface based on the multiple first gas flow rates, and the flow characteristic parameters are calculated based on the pressure data and the flow data under the multiple first gas flow rates.

30. The method according to any one of claims 22 to 29, characterized in that Also includes: The second gas flow rate is set according to the flow characteristic parameter.

31. The method of claim 22, wherein: The flow characteristic parameter is used as a reference for determining the flow rate of the second gas, including at least one of the following methods: Displaying the flow characteristic parameters; Outputting information related to the flow characteristic parameter to prompt a user to set the second gas flow rate; After identifying that the flow characteristic parameter has changed, information related to the changed flow characteristic parameter is output to prompt the user to increase or decrease the second gas flow.

32. The method of claim 22, wherein: Also includes: Delivering a plurality of first gas flow rates to the patient interface in a first ventilation phase, and calculating a flow characteristic parameter of the patient according to the pressure data and the flow data under the plurality of first gas flow rates; And in a second ventilation phase, gas is delivered to the patient interface based on a second gas flow rate to provide respiratory support to the patient.

33. A computer-readable storage medium, characterized in that: The medium stores a program, which can be executed by a processor to implement the method as claimed in any one of claims 22 to 32.

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