Photobiomodulatory therapy apparel, methods and uses

Abstract

The present specification discloses a photobiomodulation therapy garment having a garment structure configured to be worn on a skin surface by a user with one or more near-infrared light sources integrated with the garment structure. The near-infrared light source is configured to emit near-infrared light directed at one or more regions of interest of the skin at a wavelength between 600 nm and 1600 nm and having a predetermined dosimetric value and duration. A controller having a processor and a memory is in communication with the near-infrared light source to control operating parameters of the near-infrared light source.

Description

[0001] background

[0002] This patent application enjoys the priority benefit and retains the original filing date of international patent application serial number PCT / US2022 / 071626 filed on April 8, 2022, which enjoys the priority benefit and retains the original filing date of U.S. Provisional Patent Application Serial Number 63 / 272,363 filed on October 27, 2021 and U.S. Provisional Patent Application Serial Number 63 / 172,405 filed on April 8, 2021, and this patent application enjoys the priority benefit and retains the original filing date of U.S. Non-provisional patent application 17 / 658,597, which enjoys the priority benefit and retains the original filing date of U.S. Provisional Patent Application Serial Number 63 / 272,363 filed on October 27, 2021 and U.S. Provisional Patent Application Serial Number 63 / 172,405 filed on April 8, 2021, the contents of each of which are hereby incorporated by reference in their entirety.

[0003] The subject matter of this patent application generally relates to apparatus and methods for treating disease using photobiomodulation therapy utilizing near infrared light.

[0004] As background, photobiomodulation therapy is the application of near-infrared light directed to various parts of a subject's body (e.g., to the skin). Photobiomodulation therapy induces photochemical reactions in cells, increasing mitochondrial activity and ATP levels. Near-infrared light is calibrated to penetrate the skin, soft tissue, cartilage, cerebrospinal fluid, and bone structure for the purpose of providing treatment for various diseases. In an example transcranial photobiomodulation therapy, a near-infrared light source is directed toward the head so that the near-infrared light penetrates the skull to apply light to the brain for the treatment of mental health-related conditions such as stress, fatigue, ADHD, other psychiatric disorders, neuropsychiatric disorders, and neurodegenerative diseases, among others.

[0005] During treatment, one or more light sources must remain in place on the user's skin for an extended period of time. However, the user may wish to continue daily activities during treatment, which requires a portable system that remains in place during both sedentary and strenuous activities to deliver treatment accurately and without interruption. In addition, a portable system would allow for instant, real-time use, enabling the user to receive photobiomodulation therapy whenever they need it.

[0006] Aspects of the present invention satisfy these needs and provide other related advantages, as described in the following summary.

[0007] Overview

[0008] Aspects of the invention teach several benefits in construction and use which produce the exemplary advantages described below.

[0009] The specification discloses a photobiomodulation therapy garment having a garment configured to be worn by a user on a skin surface, having one or more near-infrared light sources integrated with the garment. The near-infrared light sources are configured to emit near-infrared light having a wavelength between about 700 nm and about 1600 nm and having a predetermined dose measurement value and duration directed to one or more regions of interest on the skin. A controller having a processor and a memory communicates with the near-infrared light source to control operating parameters of the near-infrared light source.

[0010] Other features and advantages of aspects of the invention will become apparent from the following more detailed description taken in conjunction with the accompanying drawings, which illustrate, by way of example, the principles of aspects of the invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] The accompanying drawings incorporated in and constituting a part of this specification illustrate various aspects of the disclosed subject matter in at least one of its exemplary embodiments, which are further defined in detail in the following description. According to one or more embodiments, features, elements, and aspects of the present disclosure are referenced by reference numerals, and similar reference numerals in different drawings represent the same, equivalent, or similar features, elements, or aspects. The drawings are not necessarily drawn to scale, but emphasis is placed on illustrating the principles described herein and provided by exemplary embodiments of the present invention. In the drawings:

[0013] Figure 1 is a top plan view of an exemplary photobiomodulation therapy kit including a photobiomodulation therapy garment disclosed herein, a controller disclosed herein, and optional cables and communications equipment;

[0014] Figure 2 is a front perspective view of an exemplary photobiomodulation therapy garment as disclosed herein worn by a user;

[0015] Figure 3 is a rear plan view of an exemplary photobiomodulation therapy garment in a deployed configuration;

[0016] Figure 4 yes Figure 3 an enlarged rear plan view of a photobiomodulation therapy garment of , showing an exemplary intergroup and intragroup arrangement of near infrared light sources;

[0017] Figure 5 yes Figure 3 A rear perspective view of the photobiomodulation therapy garment;

[0018] Figure 6 yes Figure 3 a front perspective view of a photobiomodulation therapy garment of FIG. 1 showing a detached terminal rail of a controller;

[0019] Figure 7 yes Figure 3 A front perspective view of a photobiomodulation therapy garment showing a controller disclosed herein secured to the photobiomodulation therapy garment;

[0020] Figure 8 is in a closed configuration Figure 7 A front perspective view of a photobiomodulation therapy garment of , showing an adjustment strap closed to form a band;

[0021] Fig. 9 yes Figure 6 An exploded perspective view of the photobiomodulation therapy garment;

[0022] Fig.10 is a top plan view of a photobiomodulation unit disclosed herein, the photobiomodulation unit including a flexible printed circuit board assembly;

[0023] Fig.11 yes Fig.10 an enlarged cross-sectional view of a photobiomodulation unit taken at 11-11, showing a sensor disclosed herein;

[0024] Fig.12 is a top plan view of a photobiomodulation unit disclosed herein, the photobiomodulation unit including a flexible printed circuit board assembly;

[0025] Fig.13 is a top plan view of a photobiomodulation unit disclosed herein, the photobiomodulation unit including a flexible printed circuit board assembly;

[0026] Fig.14 is a top plan view of a photobiomodulation unit disclosed herein, the photobiomodulation unit including a flexible printed circuit board assembly;

[0027] Fig.15 is a top plan view of a photobiomodulation unit disclosed herein, the photobiomodulation unit including a flexible printed circuit board assembly;

[0028] Fig.16 is an exploded rear perspective view of a photobiomodulation therapy garment disclosed herein showing a liquid conductor circuit assembly; and

[0029] Fig.17is an exploded rear perspective view of a photobiomodulation therapy garment disclosed herein, showing a liquid conductor circuit assembly;

[0030] Fig.18 is a rear plan view of an exemplary photobiomodulation therapy garment in a deployed configuration;

[0031] Fig.19 yes Fig.18 A front plan view of a photobiomodulation therapy garment showing the controller separated terminal rails;

[0032] Fig. 20 yes Fig.18 An exploded perspective view of the photobiomodulation therapy garment;

[0033] Fig.21 yes Fig.18 A top plan view of a flexible printed circuit board assembly of a photobiomodulation therapy garment;

[0034] Fig. 22 is a rear plan view of an exemplary photobiomodulation therapy garment in a deployed configuration;

[0035] Fig.23 yes Fig. 22 A front perspective view of a photobiomodulation therapy garment showing the detached terminal rails of the controller;

[0036] Fig.24 yes Fig. 22 An exploded perspective view of the photobiomodulation therapy garment;

[0037] Fig.25 yes Fig. 22 A top plan view of a flexible printed circuit board assembly of a photobiomodulation therapy garment;

[0038] Fig.26 is a front plan view of an exemplary controller disclosed herein;

[0039] Fig. 27 yes Fig.26 A rear plan view of the controller;

[0040] Fig.28 yes Fig.26 An exploded perspective view of a controller;

[0041] Fig.29 yes Fig.26 A front plan view of an exemplary control assembly of a controller;

[0042] Fig.30 yes Fig.26 a rear plan view of an exemplary control assembly of a controller;

[0043] Fig.31 yes Fig.26 A right side plan view of an exemplary control assembly of a controller;

[0044] Figure 32A-32C Shown are EEG scans of five participants from a study who underwent transcranial photobiomodulation (tPBM) treatment using the photobiomodulation therapy garment disclosed herein, wherein Fig.32A EEG scans of each participant before tPBM treatment are shown; Fig.32B shows an EEG scan of each participant after tPBM treatment; and Fig.32C EEG scans before and after merging are shown to highlight the differences; and

[0045] Figure 33A-Figure 33B A graph showing data obtained from EEG scans of participants using the photobiomodulation therapy garment disclosed herein, wherein: Fig.33A showing a percent change in frequency during use of a photobiomodulation therapy garment disclosed herein; and Fig.33B Gamma power changes over time during use of the photobiomodulation therapy garment disclosed herein are shown.

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[0050]

[0051] Detailed Description

[0052] The detailed description set forth below in conjunction with the accompanying drawings is intended to be the description of an embodiment of the present invention, and is not intended to represent that the present invention can be constructed and / or the only form of utilization. These descriptions set forth the structure and the sequence of steps for building and operating the present invention in conjunction with the embodiments shown. However, it should be understood that identical or equivalent structures and steps can be realized by different embodiments, and these embodiments are also intended to be included in the spirit and scope of the present invention.

[0053] The present system provides, in one or more embodiments, a photobiomodulation therapy garment configured to be worn by a user like any other clothing, thereby allowing full mobility and freedom of movement. The photobiomodulation therapy garment disclosed herein includes a garment configured to be worn by a user on a skin surface, the garment integrating one or more photobiomodulation units, which are configured to administer photobiomodulation therapy in combination with a controller. A photobiomodulation unit includes one or more near-infrared light sources, one or more sensors, and optionally one or more stimulators electrically connected to a connection terminal. The connection terminal is also configured to operably accommodate a controller in a manner to establish an electrical connection. Each of the one or more near-infrared light sources disclosed herein is configured to emit near-infrared light having a wavelength between 600nm and 1600nm and having a predetermined dose measurement value and duration. The controller disclosed herein has a processor and a memory, and is configured to control operating parameters of the near-infrared light source. During operation, the photobiomodulation unit is configured to emit near-infrared light to one or more head and body regions of a user. In some embodiments, as Figure 1-Figure 31 As shown, the photobiomodulation therapy garment 20 includes a garment 30 , a photobiomodulation unit 100 , and a controller 200 .

[0054] In some embodiments, Figure 2 As shown, the photobiomodulation therapy garment 20 can be configured as a photobiomodulation therapy headband 22 for treating a specific area of ​​the head H of a person P using transcranial photobiomodulation therapy. In this configuration, the person P wears the photobiomodulation therapy headband 22 by snugly wrapping the head area H, so that one or more near-infrared light sources integrated into the photobiomodulation therapy headband 22 disclosed herein are positioned above and / or directed toward the area of ​​interest on the skin surface S, for delivering a therapeutic amount of near-infrared light to the area of ​​interest. In some embodiments, the positioning of the photobiomodulation therapy headband 22 is as shown in FIG. Figure 2 As shown in , one or more near-infrared light sources disclosed herein are placed on the frontal bone region of the skull of person P, approximately and / or substantially centered about the midsagittal plane 320 (e.g., centered about the nose), for applying near-infrared light for treating disease to the brain region of person P through the skull. In addition, in these embodiments, the photobiomodulation therapy headband 22 is positioned so that one of the near-infrared light sources disclosed herein is located approximately above the brow region 322 (i.e., the brow ridge above the eye socket), and typically below the hairline (although the hairline varies from person to person). In at least one or more embodiments, at least one near-infrared light source disclosed herein and integrated into the photobiomodulation therapy headband 22 should be located above the brow region 322 or at least above the eye socket to minimize exposure of the eyes to near-infrared light. In some embodiments, as Figure 2 As shown, the photobiomodulation therapy headband 22 is positioned to cover a region of interest defined on the skin surface S, which includes one or more or all of the following items when the photobiomodulation therapy headband 22 is worn on the head H and positioned appropriately: the Fp1 site 300, the Fpz site 302, the Fp2 site 304, the F3 site 306, the Fz site 308 and the F4 site 310.

[0055] Although photobiomodulation therapy clothing 20 Figure 1-Figure 31 2 is shown as a photobiomodulation therapy headband 22, but the photobiomodulation therapy garments disclosed herein can be configured to be worn on various body parts. In some embodiments, the photobiomodulation therapy garments disclosed herein can be configured to wrap or fit a variety of body parts, with the ability to move from one area of ​​interest to another area of ​​interest on the body. In some embodiments, the photobiomodulation therapy garments disclosed herein can be specifically configured to fit specific body parts, such as as a head covering, a face covering (visor), a neck wrap, a shoulder wrap, a wrist wrap, or an abdominal wrap. In some embodiments, the photobiomodulation therapy garments disclosed herein can be configured to fit various body parts of an individual, with the ability to be worn by an individual, such as a hat, a shirt, pants, or underwear.

[0056] The photobiomodulation therapy garment 20 comprises a garment. The garment can be made flexible, semi-rigid, or rigid, and is configured to be comfortable to the user's body and configured to behave much like a piece of clothing or other wearable fashion accessory. In some embodiments, the garment disclosed herein is a fabric material made by weaving, knitting, spreading, felting, stitching, crocheting, or bonding. In some embodiments, the garment comprises multiple layers of fabric material. For example, in some embodiments, the photobiomodulation therapy garment comprises an outer fabric piece and an inner fabric piece. The outer fabric piece is sized and specified to serve as a base for mounting one or more photobiomodulation units and controllers disclosed herein, while the inner fabric component is sized and specified to at least cover one or more photobiomodulation units.

[0057] For example, in some embodiments, and see Figure 3 , Figure 5-Figure 9 , Figure 16-Figure 20 and Figure 22-Figure 24, the photobiomodulation therapy headband 22 includes a garment 30, which includes an outer fabric sheet 40 and an inner fabric sheet 70 and a photobiomodulation unit 100 sandwiched between the outer fabric sheet 40 and the inner fabric sheet 70. The outer fabric sheet 40 can be made of various natural or synthetic textiles, which are usually selected for aesthetic and / or protective qualities. The inner fabric sheet 70 is configured to rest against the skin surface S and can be made of natural or synthetic textiles or other materials that are comfortable against the skin surface S (such as space cotton, etc.). Figure 3-Figure 8 As shown in FIG. 1 , the top and bottom of the outer fabric sheet 40 and the top and bottom of the inner fabric sheet 70 are attached to each other to form the top edge 50 and the bottom edge 52 of the garment 30 in a manner to enclose the photo-biomodulation unit 100 therein.

[0058] like Figure 3 , Figure 5-Figure 9 , Figure 16-Figure 20 and Figure 22-Figure 24 As shown in the figure, the outer fabric piece 40 of the garment 30 also includes a right headband 64 extending longitudinally from the right side portion 54 of the garment 30 and a left headband 66 extending longitudinally from the left side portion 56 of the garment 30. The slider 60 allows the length of the right headband 64 to be adjusted, and the slider 62 is connected to the right headband 64 and fixed to the right headband 64 by a loop (loop) produced by the slider 60. The slider 62 is configured to accommodate the free end of the left headband 66, wherein the left headband 66 may include a hook and loop fitting portion to complete the connection. This headband device makes the photobiomodulation therapy headband 22 easy to adjust and firmly attached to the head H.

[0059] like Fig. 9 , Fig. 20 and Fig.24 As shown in FIG, the outer fabric piece 40 of the garment 30 includes a terminal rail mounting opening 58 that is sized and dimensioned to accommodate the terminal rails of the connection terminals disclosed herein in a manner that enables the controller 200 to be properly engaged to the terminal rails. Figure 3 , Figure 5-Figure 9 , Figure 16-Figure 20 and Figure 22-Figure 24 , the outer fabric piece 40 of the garment 30 further includes a controller strap 68 extending from the left side portion 56 of the garment 30. The controller strap 68 is configured to wrap around the controller 200 once the controller 200 is operably engaged to the photobiomodulation unit 100 so as to securely secure the controller 200 against the outer fabric piece 40. The controller strap 68 has a first end that is securely affixed to the garment 30 and a second end opposite the first end, and the controller strap 68 can wrap around the attached controller 200 to reversibly secure the controller 200 to the garment 30 using, for example, hook and loop fasteners, buckles, or snaps. The controller strap 68 can include a non-elastic material or an elastic material.

[0060] As in Fig. 9 , Fig.16 , Fig.17 , Fig. 20 and Fig.24 As best seen in FIG. 1 , the interior fabric piece 70 of the garment 30 includes one or more near-infrared light source openings 76 and one or more sensor openings 78. Each of the one or more near-infrared light source openings 76 is a cutout located on the interior fabric piece 70 so that when assembled, each opening 76 is aligned with the infrared light source disclosed herein in a manner that allows light from the infrared light source to be emitted through the infrared light source opening 76. Similarly, each of the one or more sensor openings 78 is a cutout located on the interior fabric piece 70 so that when assembled, each opening 78 is aligned with the sensor disclosed herein in a manner that allows the sensor to properly operate through the sensor opening 78 and collect information from the user.

[0061] In some embodiments, and see Figure 3-Figure 5 , Fig. 9 , Fig.18 , Fig. 20 , Fig. 22 and Fig.23 , the inner fabric sheet 70 may include one or more sensor covers 79. Each sensor cover 79 is located on and protects each of the one or more sensors disclosed herein and mounted on the photobiomodulation unit 100. In addition, when the photobiomodulation therapy garment 20 is worn, each of the one or more sensor covers 79 is configured to contact or be placed near the skin surface S. Each sensor cover 79 may be attached to the inner fabric sheet 70, or to the photobiomodulation unit 100 and / or sandwiched between the inner fabric sheet 70 and the photobiomodulation unit 100. In this example embodiment, each sensor cover 79 is constructed of a PVC sheet, which allows one or more sensors located thereunder to interact with the skin surface S to measure body functions (such as one or more of the following: temperature, heart rate, blood oxygen level, and other measurable functions). In addition, each sensor cover 79 provides a visual reference to help the user properly position and wear the photobiomodulation therapy garment 20. For example, when the photobiomodulation therapy headband 22 is placed around the head H, one or more sensor covers 79 may be manually aligned with the nose, placing the sensor cover 79 generally in the sagittal plane 320 .

[0062] The photobiomodulation therapy garment 20 also includes a photobiomodulation unit. The photobiomodulation unit includes a connection terminal, one or more near-infrared light sources, one or more sensors, and is configured to establish electronic communication with the controller 200. In some embodiments, and see Fig. 9 , Fig.10, Figure 12-Figure 15 , Fig. 20 , Fig.21 , Fig.24 and Fig.25 , the photobiomodulation unit 100 includes a flexible printed circuit board assembly 110 that provides a flexible substrate that houses circuits that establish electronic communication between a connection terminal 160 and one or more near-infrared light sources 170 (e.g., infrared light, a low-level laser, and / or a light-emitting diode (LED)), one or more sensors 180, and optionally one or more stimulators 194. The connection terminal 160 (generally rigid or semi-rigid) includes an electronic circuit connector 162 mounted thereon, wherein the electronic circuit connector 162 is configured to provide electronic communication between the controller 200 and the flexible printed circuit board assembly 110. In these embodiments, the flexible printed circuit board assembly 110 is configured to provide flexibility and comfort to the wearer. For example, because the photobiomodulation therapy headband 22 must fit closely to the contours of the forehead, the flexible printed circuit board assembly 110 is designed with strategic cutouts to achieve maximum flexibility and comfort. In some embodiments, and as Figure 8 and Fig.10 As shown, the FPA 110 includes a heat sink material 102 on the flexible substrate on opposite sides of the circuit that dissipates heat generated by the FPA 110 during operation of the photobiomodulation therapy garment 20 .

[0063] In some embodiments, and see Fig.10 , Figure 12-Figure 15 , Fig.21 and Fig.25 The flexible printed circuit board assembly 110 is a thin and flat substrate including a first surface and a second surface opposite to the first surface, and the substrate is configured as a main strip 112 extending from the connection terminal 160 and bifurcating at a root 113 into a first strip 114, a second strip 116, and a sensor strip 140 extending from the middle. The first strip 114 and the second strip 116 are connected at the distal end by a connecting portion 117, and all of them define the boundary of the cutout 118. The first strip 114 and the second strip 116 contain electronic circuits required to establish electronic communication between each near-infrared light source 170 operably mounted on the first strip 114 or the second strip 116 and the connection terminal 160.

[0064] In some embodiments, the first belt 114 and the second belt 116 each include a series of tabs extending laterally outward therefrom for mounting the near infrared light source disclosed herein thereon. Fig.10 and Fig.12 As shown, the first tape 114 includes a first mounting portion 120, a second mounting portion 122, and a third mounting portion 124, wherein the first mounting portion 120 is separated from the second mounting portion 122 by a first cutout 121 therebetween, and the third mounting portion 124 is separated from the second mounting portion 122 by a second cutout 123 therebetween. Similarly, the second tape 116 includes a first mounting portion 130, a second mounting portion 132, and a third mounting portion 134, wherein the first mounting portion 130 is separated from the second mounting portion 132 by a first cutout 131 therebetween, and the third mounting portion 134 is separated from the second mounting portion 132 by a second cutout 133 therebetween. The first mounting portion 120, the second mounting portion 122, the third mounting portion 124 of the first tape 114 and the first mounting portion 130, the second mounting portion 132, the third mounting portion 134 of the second tape 116 are like gores, which allows the flexible printed circuit board assembly 110 to be flexibly bent independently. This flexible bending allows the flexible printed circuit board assembly 110 to easily conform to the contours of one or more areas of interest of the skin area S and place each of the one or more near infrared light sources disclosed herein near the skin surface S with minimal or no gap.

[0065] In some embodiments, and see Fig.10 , Figure 12-Figure 15 , Fig.21 and Fig.25 , the sensor strip 140 includes a sensor mounting portion 142 and a free end 144. The sensor strip 140 extends from the root 113 into the cutout 118 in the following manner: the cutout 118 provides a gap between the sensor strip 140 and the first strip 114 and the second strip 116, thereby disconnecting the sensor strip 140 from the first strip 114 and the second strip 116 except at the root 113. The sensor strip 140 contains electronic circuits required to establish electronic communication between each sensor 180 operably mounted on the sensor strip 140 and the connection terminals 160. The sensor strip 140 is relatively thin and long to allow bending and slight movement of the sensor strip 140 relative to the rest of the flexible printed circuit board assembly 110, which is additionally allowed due to the sensor opening 254 provided by the double-sided tape 250 (see Fig. 9 , Fig.16 , Fig.17 , Fig. 20 and Fig.24 ), which allows for easy bending and installation around the head H with few or no kinks in the flexible printed circuit board assembly 110.

[0066] In some embodiments, and see Fig. 20, Fig.21 , Fig.24 and Fig.25 , the photobiomodulation unit 100 includes a flexible printed circuit board assembly 110 that provides a flexible substrate that houses circuits that establish electronic communication between a connection terminal 160 and one or more near-infrared light sources 170 (such as infrared light, low-intensity lasers and / or light-emitting diodes (LEDs)), one or more sensors 180, and one or more stimulators 194 (such as a transcranial direct current stimulator or a transcranial magnetic stimulator). The connection terminal 160 (generally rigid or semi-rigid) includes an electronic circuit connector 162 mounted thereon, wherein the electronic circuit connector 162 is configured to provide electronic communication between the controller 200 and the flexible printed circuit board assembly 110. In these embodiments, the flexible printed circuit board assembly 110 is configured to provide flexibility and comfort to the wearer. For example, because the photobiomodulation therapy headband 22 must fit closely to the contours of the forehead, the flexible printed circuit board assembly 110 is designed with globally arranged cutouts to achieve maximum flexibility and comfort.

[0067] In some embodiments, and see Figure 6 , Fig. 9 , Fig.10 , Figure 12-Figure 17 , Figure 19-21 and Figure 23-Figure 25, the connection terminal 160 is integrally mounted to one end of the flexible printed circuit board assembly 110. The connection terminal 160 includes an electronic circuit connector 162 and a terminal guide bracket 164. The electronic circuit connector 162 of the connection terminal 160 is located on the same surface of the flexible printed circuit board assembly 110, where one or more infrared light sources 170, one or more sensors 180, and one or more stimulators 194 are mounted, and the flexible printed circuit board assembly 110 contains a circuit for establishing electronic communication with the one or more infrared light sources 170, one or more sensors 180, and one or more stimulators 194. The terminal guide bracket 164 of the connection terminal 160 is located on the flexible printed circuit board assembly 110, on the opposite side of the electronic circuit connector 162. The terminal guide bracket 164 includes a plurality of contacts 166. The terminal rail bracket 164 is configured to accommodate the controller 200 and, when connected, establish electronic communication between the photobiomodulation unit 100 and the controller 200, which has corresponding contacts that mate with the contacts 166. To allow for quick connection and disconnection, the controller 200 and the terminal rail bracket 164 include sliding joinery (e.g., a dovetail and tongue or grooves similar to joinery) to capture the controller 200 within the terminal rail bracket 164 and force electrical contact between the contacts 166 of the terminal rail bracket 164 and corresponding contacts protruding through the controller 200. After sliding the controller 200 into the terminal rail bracket 164, the controller strap 68 is wrapped over the controller 200 and secured to the inner portion 44 of the outer fabric sheet 40 by a releasable connection (such as a hook and loop).

[0068] In some embodiments, and see Fig.16 and Fig.17, the photobiomodulation unit 100 includes a liquid wire circuit assembly 150 that provides electronic communication between a connection terminal 160 and one or more near-infrared light sources 170 (e.g., infrared light, low-intensity lasers and / or light-emitting diodes (LEDs)), one or more sensors 180, and optionally one or more stimulators 194. The liquid wire includes a metal that remains in a liquid phase at room temperature and is encapsulated in a flexible tube. Due to its liquid phase properties, the liquid metal can make good contact with objects of any shape and can maintain excellent electrical properties when the substrate or cover film is deformed. Non-limiting examples of liquid metals include gallium and alloys (such as eutectic gallium indium). The liquid wire circuit assembly 150 includes a connection terminal 160, on which an electronic circuit connector 162 is mounted, wherein the electronic circuit connector 162 is configured to provide electrical communication between one or more liquid wire tubes of the circuit assembly 150 and the connection terminal 160. In these embodiments, the liquid wire circuit assembly 150 is configured to provide flexibility and comfort to the wearer. For example, because the photobiomodulation therapy headband 22 must fit closely to the forehead contour, the liquid wire circuit assembly 150 is designed with globally arranged cutouts to achieve maximum flexibility and comfort.

[0069] In some embodiments, and see Fig.16 and Fig.17 , the liquid wire circuit assembly 150 includes a main liquid wire tube 152, which extends from a connection terminal 160 and is bifurcated at a root 153 into a sensor liquid wire tube 158 extending from a middle portion directly attached to the inner surface of the outer fabric sheet 40, a first liquid wire tube 154, and a second liquid wire tube 156. The first liquid wire tube 154 and the second liquid wire tube 156 contain electronic circuits required to establish electrical connections between each near-infrared light source 170 operably mounted to the first liquid wire tube 154 or the second liquid wire tube 156 and the connection terminal 160, which in turn provides electrical connections to the controller 200. The sensor liquid wire tube 158 contains electronic circuits required to establish electrical communication between each sensor 180 and / or each stimulator 194 operably mounted to the sensor liquid wire tube 158 and the connection terminal 160, which in turn provides electrical connections to the controller 200. The first liquid conduit 154, the second liquid conduit 156, and the sensor liquid conduit 158 ​​are directly attached to the inner surface of the outer fabric sheet 40, so that the liquid conduit circuit assembly 150 can be easily conformed to the contours of one or more areas of interest of the skin area S, and each of the one or more near-infrared light sources disclosed herein is placed near the skin surface S with minimal or no gap. Although not shown, the liquid conduit circuit assembly 150 can be arranged in a manner similar to that of the outer fabric sheet 40. Figure 13-Figure 15The flexible printed circuit board assembly 110 may be configured similarly to the arrangement shown.

[0070] See also Fig.10 , Figure 12-Figure 17 , Fig.21 and Fig.25 , the photobiomodulation unit 100 also includes one or more near-infrared light sources 170, each of which is configured to emit near-infrared light having a wavelength range of 700nm to 1600nm. In some embodiments, the near-infrared light sources 170 emit light having, for example, a wavelength of about 700nm, about 750nm, about 800nm, about 900nm, about 1000nm, about 1100nm, about 1200nm, about 1.300nm, about 1400nm, or about 1500nm. In some embodiments, the near-infrared light sources 170 emit light having, for example, a wavelength of at least 700nm, at least 750nm, at least 800nm, at least 850nm, at least 900nm, at least 1000nm, at least 1100nm, at least 1200nm, at least 1.300nm, at least 1400nm, or at least 1500nm. In some embodiments, the near-infrared light source 170 emits light having a wavelength of, for example, at most 700 nm, at most 750 nm, at most 800 nm, at most 850 nm, at most 900 nm, at most 1000 nm, at most 1100 nm, at most 1200 nm, at most 1.300 nm, at most 1400 nm, or at most 1500 nm.

[0071] In some embodiments, the near infrared light source 170 emits light having a wavelength of, for example, about 700 nm to about 750 nm, about 700 nm to about 800 nm, about 700 nm to about 900 nm, about 700 nm to about 1000 nm, about 700 nm to about 1100 nm, about 700 nm to about 1200 nm, about 700 nm to about 1300 nm, about 700 nm to about 1400 nm, about 700 nm to about 1500 nm, about 750 nm to about 800 nm, about 750 nm to about 850 nm, about 750 nm to about 900 nm, about 750 nm to about 1000nm, about 750nm to about 1100nm, about 750nm to about 1200nm, about 750nm to about 1300nm, about 750nm to about 1400nm, about 750nm to about 1500nm, about 800nm ​​to about 850nm, about 800nm ​​to about 900nm, about 800nm ​​to about 1000nm, about 800nm ​​to about 1100nm, about 800nm ​​to about 1200nm, about 800nm ​​to about 1300nm, about 800nm ​​to about 1400nm, about 800nm ​​to about 1500nm, about 850nm to about 900nm m, about 850nm to about 1000nm, about 850nm to about 1100nm, about 850nm to about 1200nm, about 850nm to about 1300nm, about 850nm to about 1400nm, about 850nm to about 1500nm, about 900nm to about 1000nm, about 900nm to about 1100nm, about 900nm to about 1200nm, about 900nm to about 1300nm, about 900nm to about 1400nm, about 900nm to about 1500nm, about 1000nm to about 1100nm, about 1000nm to about 1200nm nm, about 1000 nm to about 1300 nm, about 1000 nm to about 1400 nm, about 1000 nm to about 1500 nm, about 1100 nm to about 1200 nm, about 1100 nm to about 1300 nm, about 1100 nm to about 1400 nm, about 1100 nm to about 1500 nm, about 1200 nm to about 1300 nm, about 1200 nm to about 1400 nm, about 1200 nm to about 1500 nm, about 1300 nm to about 1400 nm, about 1300 nm to about 1500 nm, or about 1400 nm to about 1500 nm.

[0072] In some embodiments, one or more near-infrared light sources 170 are each configured to emit near-infrared light with a pulse wave (or frequency) ranging from about 1 Hz to about 100 Hz. In some embodiments, the near-infrared light source 170 emits light with, for example, the following pulse waves: about 10 Hz, about 20 Hz, about 30 Hz, about 40 Hz, about 50 Hz, about 60 Hz, about 70 Hz, about 80 Hz, about 90 Hz, or about 100 Hz. In some embodiments, the near-infrared light source 170 emits light with, for example, the following pulse waves: at least 10 Hz, at least 20 Hz, at least 30 Hz, at least 40 Hz, at least 50 Hz, at least 60 Hz, at least 70 Hz, at least 80 Hz, at least 90 Hz, or at least 100 Hz. In some embodiments, near-infrared light source 170 emits light having a pulse wave of, for example, at most 10 Hz, at most 20 Hz, at most 30 Hz, at most 40 Hz, at most 50 Hz, at most 60 Hz, at most 70 Hz, at most 80 Hz, at most 90 Hz, or at most 100 Hz. In some embodiments, the near-infrared light source 170 emits light having a pulse wave of, for example, about 10 Hz to about 20 Hz, about 10 Hz to about 30 Hz, about 10 Hz to about 40 Hz, about 10 Hz to about 50 Hz, about 10 Hz to about 60 Hz, about 10 Hz to about 70 Hz, about 10 Hz to about 80 Hz, about 10 Hz to about 90 Hz, about 10 Hz to about 100 Hz, about 20 Hz to about 30 Hz, about 20 Hz to about 40 Hz, about 20 Hz to about 50 Hz, about 20 Hz to about 60 Hz, about 20 Hz to about 70 Hz, about 20 Hz to about 80 Hz, about 20 Hz to about 90 Hz, about 20 Hz to about 100 Hz, about 30 Hz to about 40 Hz, about 30 Hz to about 50 Hz, about 30 Hz to about 60 Hz, about 30 Hz to about 70 Hz, To about 80 Hz, about 30 Hz to about 90 Hz, about 30 Hz to about 100 Hz, about 40 Hz to about 50 Hz, about 40 Hz to about 60 Hz, about 40 Hz to about 70 Hz, about 40 Hz to about 80 Hz, about 40 Hz to about 90 Hz, about 40 Hz to about 100 Hz, about 50 Hz to about 60 Hz, about 50 Hz to about 70 Hz, about 50 Hz to about 80 Hz, about 50 Hz to about 90 Hz, about 50 Hz to about 100 Hz, about 60 Hz to about 70 Hz, about 60 Hz to about 80 Hz, about 60 Hz to about 90 Hz, about 60 Hz to about 100 Hz, about 70 Hz to about 80 Hz, about 70 Hz to about 90 Hz, about 70 Hz to about 100 Hz, about 80 Hz to about 90 Hz, about 80 Hz to about 100 Hz, or about 90 Hz to about 100 Hz.

[0073] In some embodiments, one or more near-infrared light sources 170 are each configured to emit near-infrared light with a pulse wave (or frequency) ranging from about 100 Hz to about 1000 Hz. In some embodiments, the near-infrared light source 170 emits light having, for example, the following pulse waves: about 100 Hz, about 200 Hz, about 300 Hz, about 400 Hz, about 500 Hz, about 600 Hz, about 700 Hz, about 800 Hz, about 900 Hz, or about 1000 Hz. In some embodiments, the near-infrared light source 170 emits light having, for example, the following pulse waves: at least 100 Hz, at least 200 Hz, at least 300 Hz, at least 400 Hz, at least 500 Hz, at least 600 Hz, at least 700 Hz, at least 800 Hz, at least 900 Hz, or at least 1000 Hz. In some embodiments, near-infrared light source 170 emits light having a pulse wave of, for example, at most 100 Hz, at most 200 Hz, at most 300 Hz, at most 400 Hz, at most 500 Hz, at most 600 Hz, at most 700 Hz, at most 800 Hz, at most 900 Hz, or at most 1000 Hz.In some embodiments, the near-infrared light source 170 emits light having a pulse wave of, for example, about 100 Hz to about 200 Hz, about 100 Hz to about 300 Hz, about 100 Hz to about 400 Hz, about 100 Hz to about 500 Hz, about 100 Hz to about 600 Hz, about 100 Hz to about 700 Hz, about 100 Hz to about 800 Hz, about 100 Hz to about 900 Hz, about 100 Hz to about 1000 Hz, about 200 Hz to about 3 ...0 Hz, about 0 Hz, about 200 Hz to about 400 Hz, about 200 Hz to about 500 Hz, about 200 Hz to about 600 Hz, about 200 Hz to about 700 Hz, about 200 Hz to about 800 Hz, about 200 Hz to about 900 Hz, about 200 Hz to about 1000 Hz, about 300 Hz to about 400 Hz, about 300 Hz to about 500 Hz, about 300 Hz to about 600 Hz, about 300 Hz to about 700 Hz, about 3 ... 800Hz, about 300Hz to about 900Hz, about 300Hz to about 1000Hz, about 400Hz to about 500Hz, about 400Hz to about 600Hz, about 400Hz to about 700Hz, about 400Hz to about 800Hz, about 400Hz to about 900Hz, about 400Hz to about 1000Hz, about 500Hz to about 600Hz, about 500Hz to about 700Hz, about 500Hz to about 800Hz, about 500Hz to about 900Hz, about 400Hz to about 1000Hz, about 500Hz to about 600Hz, about 500Hz to about 700Hz, about 500Hz to about 800Hz, about 500Hz to about z to about 900 Hz, about 500 Hz to about 1000 Hz, about 600 Hz to about 700 Hz, about 600 Hz to about 800 Hz, about 600 Hz to about 900 Hz, about 600 Hz to about 1000 Hz, about 700 Hz to about 800 Hz, about 700 Hz to about 900 Hz, about 700 Hz to about 1000 Hz, about 800 Hz to about 900 Hz, about 800 Hz to about 1000 Hz or about 900 Hz to about 1000 Hz.

[0074] In some embodiments, one or more near infrared light sources 170 are each configured to emit near infrared light with a pulse wave (or frequency) ranging from about 1000 Hz to about 5000 Hz. In some embodiments, the near infrared light source 170 emits light with a pulse wave of, for example, about 1000 Hz, about 2000 Hz, about 3000 Hz, about 4000 Hz, or about 5000 Hz. In some embodiments, the near infrared light source 170 emits light with a pulse wave of, for example, at least 1000 Hz, at least 2000 Hz, at least 3000 Hz, at least 4000 Hz, or at least 5000 Hz. In some embodiments, the near infrared light source 170 emits light with a pulse wave of, for example, at most 1000 Hz, at most 2000 Hz, at most 3000 Hz, at most 4000 Hz, or at most 5000 Hz. In some embodiments, the near-infrared light source 170 emits light having a pulse wave of, for example, about 1000 Hz to about 2000 Hz, about 1000 Hz to about 3000 Hz, about 1000 Hz to about 4000 Hz, about 1000 Hz to about 5000 Hz, about 2000 Hz to about 3000 Hz, about 2000 Hz to about 4000 Hz, about 2000 Hz to about 5000 Hz, about 3000 Hz to about 4000 Hz, about 3000 Hz to about 5000 Hz, or about 4000 Hz to about 5000 Hz.

[0075] In some embodiments, one or more near-infrared light sources 170 are each configured to emit near-infrared light having a radiant energy ranging from about 100 J to about 1100 J. In some embodiments, near-infrared light sources 170 have, for example, radiant energies of about 100 J, about 200 J, about 300 J, about 400 J, about 500 J, about 600 J, about 700 J, about 800 J, about 900 J, about 1000 J, or about 1100 J. In some embodiments, near-infrared light sources 170 have, for example, radiant energies of at least 100 J, at least 200 J, at least 300 J, at least 400 J, at least 500 J, at least 600 J, at least 700 J, at least 800 J, at least 900 J, at least 1000 J, or at least 1100 J. In some embodiments, near infrared light source 170 has a radiation energy of, for example, at most 100 J, at most 200 J, at most 300 J, at most 400 J, at most 500 J, at most 600 J, at most 700 J, at most 800 J, at most 900 J, at most 1000 J, or at most 1100 J.In some embodiments, the near infrared light source 170 has a radiation energy of, for example, about 100 J to about 200 J, about 100 J to about 300 J, about 100 J to about 400 J, about 100 J to about 500 J, about 100 J to about 600 J, about 100 J to about 700 J, about 100 J to about 800 J, about 100 J to about 900 J, about 100 J to about 1000 J, about 100 J to about 1100 J, about 200 J to about 300 J, about 200 J to about 400 J, about 2 ... J to about 500J, about 200J to about 600J, about 200J to about 700J, about 200J to about 800J, about 200J to about 900J, about 200J to about 1000J, about 200J to about 1100J, about 300J to about 400J, about 300J to about 500J, about 300J to about 600J, about 300J to about 700J, about 300J to about 800J, about 300J to about 900J, about 300J to about 1000J, about 300J to about 1100J, 0J, about 400J to about 500J, about 400J to about 600J, about 400J to about 700J, about 400J to about 800J, about 400J to about 900J, about 400J to about 1000J, about 400J to about 1100J, about 500J to about 600J, about 500J to about 700J, about 500J to about 800J, about 500J to about 900J, about 500J to about 1000J, about 500J to about 1100J, about 600J to about 700J, about J to about 800J, about 600J to about 900J, about 600J to about 1000J, about 600J to about 1100J, about 700J to about 800J, about 700J to about 900J, about 700J to about 1000J, about 700J to about 1100J, about 800J to about 900J, about 800J to about 1000J, about 800J to about 1100J, about 900J to about 1000J, about 900J to about 1100J or about 1000J to about 1100J.

[0076] In some embodiments, one or more near-infrared light sources 170 are each configured to emit near-infrared light having a radiant energy ranging from about 500 J to about 7000 J. In some embodiments, near-infrared light sources 170 have, for example, radiant energies of about 500 J, about 750 J, about 1000 J, about 1500 J, about 2000 J, about 2500 J, about 3000 J, about 3500 J, about 4000 J, about 4500 J, about 5000 J, about 5500, about 6000 J, about 6500 J, or about 7000 J. In some embodiments, near-infrared light source 170 has a radiation energy of, for example, at least 500 J, at least 750 J, at least 1000 J, at least 1500 J, at least 2000 J, at least 2500 J, at least 3000 J, at least 3500 J, at least 4000 J, at least 4500 J, at least 5000 J, at least 5500, at least 6000 J, at least 6500 J, or at least 7000 J. In some embodiments, the near-infrared light source 170 has a radiation energy of, for example, at most 500 J, at most 750 J, at most 1000 J, at most 1500 J, at most 2000 J, at most 2500 J, at most 3000 J, at most 3500 J, at most 4000 J, at most 4500 J, at most 5000 J, at most 5500, at most 6000 J, at most 6500 J or at most 7000 J. In some embodiments, the near infrared light source 170 has a radiation energy of, for example, about 500 J to about 1000 J, about 500 J to about 1500 J, about 500 J to about 2000 J, about 500 J to about 2500 J, about 500 J to about 3000 J, about 500 J to about 3500 J, about 500 J to about 4000 J, about 500 J to about 4500 J, about 500 J to about 5000 J, about 500 J to about 5500 J, about 500 J to about 6000 J, about 500 J to about 6500 J, about 500 J to about 7000 J, about 750 J to about 1000 J, about 750 J to about 1500 J, about 750 J to about 2000 J, about 750 J to about 2500 J, about 750 J to about 3000 J, about 750 J to about about 3500J, about 750J to about 4000J, about 750J to about 4500J, about 750J to about 5000J, about 750J to about 5500J, about 750J to about 6000J, about 750J to about 6500J, about 750J to about 7000J, about 1000J to about 1500J, about 1000J to about 2000J, about 1000J to about About 2500J, about 1000J to about 3000J, about 1000J to about 3500J, about 1000J to about 4000J, about 1000J to about 4500J, about 1000J to about 5000J, about 1000J to about 5500J, about 1000J to about 6000J, about 1000J to about 6500J or about 1000J to about 7000J.

[0077] In some embodiments, one or more near-infrared light sources 170 are each configured to emit an irradiance (flux density) in the range of about 5 mW / cm 2 About 100mW / cm 2 In some embodiments, the near-infrared light source 170 has an irradiance (flux density) of, for example, about 5 mW / cm 2 , about 10mW / cm 2 , about 15mW / cm 2 , about 20mW / cm 2 , about 25mW / cm 2 , about 30mW / cm 2 , about 35mW / cm 2 , about 40mW / cm 2 , about 50mW / cm 2 , about 60mW / cm 2 , about 70mW / cm 2 , about 80mW / cm 2 , about 90mW / cm 2 or about 100mW / cm 2 In some embodiments, the near-infrared light source 170 has an irradiance (flux density) of, for example, at least 5 mW / cm 2 , at least 10mW / cm 2 , at least 15mW / cm 2 , at least 20mW / cm 2 , at least 25mW / cm 2 , at least 30mW / cm 2 , at least 35mW / cm 2 , at least 40mW / cm 2 , at least 50mW / cm 2 , at least 60mW / cm 2 , at least 70mW / cm 2 , at least 80mW / cm 2 , at least 90mW / cm 2 or at least 100mW / cm 2 In some embodiments, near infrared light source 170 has an irradiance (flux density) of, for example, at most 5 mW / cm 2 , up to 10mW / cm 2 , up to 15mW / cm 2 , up to 20mW / cm 2 , up to 25mW / cm 2 , up to 30mW / cm 2, up to 35mW / cm 2 , up to 40mW / cm 2 , up to 50mW / cm 2 , up to 60mW / cm 2 , up to 70mW / cm 2 , up to 80mW / cm 2 , up to 90mW / cm 2 or up to 100mW / cm 2 In some embodiments, the near-infrared light source 170 has an irradiance (flux density) of, for example, about 5 mW / cm 2 to about 10mW / cm 2 , about 5mW / cm 2 to about 15mW / cm 2 , about 5mW / cm 2 to about 20mW / cm 2 , about 5mW / cm 2 to about 25mW / cm 2 , about 5mW / cm 2 to about 30mW / cm 2 , about 5mW / cm 2 to about 35mW / cm 2 , about 10mW / cm 2 to about 15mW / cm 2 , about 10mW / cm 2 to about 20mW / cm 2 , about 10mW / cm 2 to about 25mW / cm 2 , about 10mW / cm 2 to about 30mW / cm 2 , about 10mW / cm 2 to about 35mW / cm 2 , about 15mW / cm 2 to about 20mW / cm 2 , about 15mW / cm 2 to about 25mW / cm 2 , about 15mW / cm 2 to about 30mW / cm 2 , about 15mW / cm 2 to about 35mW / cm 2 , about 20mW / cm 2 to about 25mW / cm 2 , about 20mW / cm 2 to about 30mW / cm 2 , about 20mW / cm 2 to about 35mW / cm2 , about 25mW / cm 2 to about 30mW / cm 2 About 25mW / cm 2 to about 35mW / cm 2 or about 30mW / cm 2 to about 35mW / cm 2 In some embodiments, the near-infrared light source 170 has an irradiance (flux density) of, for example, about 20 mW / cm 2 to about 50mW / cm 2 , about 20mW / cm 2 to about 60mW / cm 2 , about 20mW / cm 2 to about 70mW / cm 2 , about 20mW / cm 2 to about 80mW / cm 2 , about 20mW / cm 2 to about 90mW / cm 2 , about 20mW / cm 2 About 100mW / cm 2 , about 30mW / cm 2 to about 60mW / cm 2 , about 30mW / cm 2 to about 70mW / cm 2 , about 30mW / cm 2 to about 80mW / cm 2 , about 30mW / cm 2 to about 90mW / cm 2 , about 30mW / cm 2 About 100mW / cm 2 , about 40mW / cm 2 to about 60mW / cm 2 , about 40mW / cm 2 to about 70mW / cm 2 , about 40mW / cm 2 to about 80mW / cm 2 , about 40mW / cm 2 to about 90mW / cm 2 , about 40mW / cm 2 About 100mW / cm 2 , about 50mW / cm 2 to about 60mW / cm 2 , about 50mW / cm 2 to about 70mW / cm 2 , about 50mW / cm 2 to about 80mW / cm2 , about 50mW / cm 2 to about 90mW / cm 2 , about 50mW / cm 2 About 100mW / cm 2 , about 60mW / cm 2 to about 70mW / cm 2 , about 60mW / cm 2 to about 80mW / cm 2 , about 60mW / cm 2 to about 90mW / cm 2 , about 60mW / cm 2 About 100mW / cm 2 , about 70mW / cm 2 to about 80mW / cm 2 , about 70mW / cm 2 to about 90mW / cm 2 , about 70mW / cm 2 About 100mW / cm 2 , about 80mW / cm 2 to about 90mW / cm 2 , about 80mW / cm 2 About 100mW / cm 2 or about 90mW / cm 2 About 100mW / cm 2 .

[0078] In some embodiments, one or more near-infrared light sources 170 are each configured to emit an irradiance (flux density) in the range of about 100 mW / cm 2 About 1000mW / cm 2 In some embodiments, the near-infrared light source 170 has, for example, an irradiance (flux density) of about 50 mW / cm 2 , about 100mW / cm 2 , about 150mW / cm 2 , about 200mW / cm 2 , about 250mW / cm 2 , about 300mW / cm 2 , about 350mW / cm 2 , about 400mW / cm 2 , about 450mW / cm 2 , about 500mW / cm 2 , about 600mW / cm 2 , about 700mW / cm 2 , about 800mW / cm 2, about 900mW / cm 2 or about 1000mW / cm 2 In some embodiments, near-infrared light source 170 has an irradiance (flux density) of, for example, at least 50 mW / cm 2 , at least 100mW / cm 2 , at least 150mW / cm 2 , at least 200mW / cm 2 , at least 250mW / cm 2 , at least 300mW / cm 2 , at least 350mW / cm 2 , at least 400mW / cm 2 , at least 450mW / cm 2 , at least 500mW / cm 2 , at least 600mW / cm 2 , at least 700mW / cm 2 , at least 800mW / cm 2 , at least 900mW / cm 2 or at least 1000mW / cm 2 In some embodiments, near infrared light source 170 has an irradiance (flux density) of, for example, at most 50 mW / cm 2 , up to 100mW / cm 2 , up to 150mW / cm 2 , up to 200mW / cm 2 , up to 250mW / cm 2 , up to 300mW / cm 2 , up to 350mW / cm 2 , up to 400mW / cm 2 , up to 450mW / cm 2 , up to 500mW / cm 2 , up to 600mW / cm 2 , up to 700mW / cm 2 , up to 800mW / cm 2 , up to 900mW / cm 2 or up to 1000mW / cm 2 In some embodiments, the near-infrared light source 170 has an irradiance (flux density) of, for example, about 50 mW / cm 2 About 100mW / cm 2 , about 50mW / cm 2 to about 150mW / cm 2 , about 50mW / cm 2 About 200mW / cm 2, about 50mW / cm 2 to about 250mW / cm 2 , about 50mW / cm 2 About 300mW / cm 2 , about 50mW / cm 2 to about 350mW / cm 2 , about 50mW / cm 2 To about 400mW / cm 2 , about 50mW / cm 2 to about 450mW / cm 2 , about 50mW / cm 2 To about 500mW / cm 2 , about 50mW / cm 2 to about 600mW / cm 2 , about 50mW / cm 2 to about 700mW / cm 2 , about 50mW / cm 2 To about 800mW / cm 2 , about 50mW / cm 2 To about 900mW / cm 2 , about 50mW / cm 2 About 1000mW / cm 2 , about 100mW / cm 2 About 200mW / cm 2 , about 100mW / cm 2 to about 250mW / cm 2 , about 100mW / cm 2 About 300mW / cm 2 , about 100mW / cm 2 to about 350mW / cm 2 , about 100mW / cm 2 To about 400mW / cm 2 , about 100mW / cm 2 to about 450mW / cm 2 , about 100mW / cm 2 To about 500mW / cm 2 , about 100mW / cm 2 to about 600mW / cm 2 , about 100mW / cm 2 to about 700mW / cm 2 , about 100mW / cm 2 To about 800mW / cm 2 , about 100mW / cm 2 To about 900mW / cm 2, about 100mW / cm 2 About 1000mW / cm 2 , about 150mW / cm 2 About 200mW / cm 2 , about 150mW / cm 2 to about 250mW / cm 2 , about 150mW / cm 2 About 300mW / cm 2 , about 150mW / cm 2 to about 350mW / cm 2 , about 150mW / cm 2 To about 400mW / cm 2 , about 150mW / cm 2 to about 450mW / cm 2 , about 150mW / cm 2 To about 500mW / cm 2 , about 150mW / cm 2 to about 600mW / cm 2 , about 150mW / cm 2 to about 700mW / cm 2 , about 150mW / cm 2 To about 800mW / cm 2 , about 150mW / cm 2 To about 900mW / cm 2 , about 150mW / cm 2 About 1000mW / cm 2 , about 200mW / cm 2 About 300mW / cm 2 , about 200mW / cm 2 to about 350mW / cm 2 , about 200mW / cm 2 To about 400mW / cm 2 , about 200mW / cm 2 to about 450mW / cm 2 , about 200mW / cm 2 To about 500mW / cm 2 , about 200mW / cm 2 to about 600mW / cm 2 , about 200mW / cm 2 to about 700mW / cm 2 , about 200mW / cm 2 To about 800mW / cm 2 , about 200mW / cm 2 To about 900mW / cm2 , about 200mW / cm 2 About 1000mW / cm 2 , about 300mW / cm 2 To about 400mW / cm 2 , about 300mW / cm 2 To about 500mW / cm 2 , about 300mW / cm 2 to about 600mW / cm 2 , about 300mW / cm 2 to about 700mW / cm 2 , about 300mW / cm 2 To about 800mW / cm 2 , about 300mW / cm 2 To about 900mW / cm 2 , about 300mW / cm 2 About 1000mW / cm 2 , about 400mW / cm 2 To about 500mW / cm 2 , about 400mW / cm 2 to about 600mW / cm 2 , about 400mW / cm 2 to about 700mW / cm 2 , about 400mW / cm 2 To about 800mW / cm 2 , about 400mW / cm 2 To about 900mW / cm 2 , about 400mW / cm 2 About 1000mW / cm 2 , about 500mW / cm 2 to about 600mW / cm 2 , about 500mW / cm 2 to about 700mW / cm 2 , about 500mW / cm 2 To about 800mW / cm 2 , about 500mW / cm 2 To about 900mW / cm 2 , about 500mW / cm 2 About 1000mW / cm 2 , about 600mW / cm 2 to about 700mW / cm 2 , about 600mW / cm 2 To about 800mW / cm 2 , about 600mW / cm2 To about 900mW / cm 2 , about 600mW / cm 2 About 1000mW / cm 2 , about 700mW / cm 2 To about 800mW / cm 2 , about 700mW / cm 2 To about 900mW / cm 2 , about 700mW / cm 2 About 1000mW / cm 2 , about 800mW / cm 2 To about 900mW / cm 2 , about 800mW / cm 2 About 1000mW / cm 2 or about 900mW / cm 2 About 1000mW / cm 2 .

[0079] In some embodiments, one or more near infrared light sources 170 are each configured to emit light at about 5 J / cm 2 About 200 J / cm 2 In some embodiments, the near-infrared light source 170 has a radiation exposure (luminous flux) of, for example, about 5 J / cm 2 , about 10J / cm 2 , about 15J / cm 2 , about 20J / cm 2 , about 30J / cm 2 , about 40J / cm 2 , about 50J / cm 2 , about 60J / cm 2 , about 65J / cm 2 , about 70J / cm 2 , about 75J / cm 2 , about 80J / cm 2 , about 85J / cm 2 , about 90J / cm 2 , about 100J / cm 2 , about 110J / cm 2 , about 120J / cm 2 , about 130J / cm 2 , about 140J / cm 2 , about 150J / cm 2 , about 160J / cm 2 , about 170J / cm 2 , about 175J / cm2 , about 180J / cm 2 , about 190J / cm 2 or about 200 J / cm 2 In some embodiments, the near-infrared light source 170 has a radiation exposure (luminous flux) of at least 5 J / cm 2 , at least 10J / cm 2 , at least 15J / cm 2 , at least 20J / cm 2 , at least 30J / cm 2 , at least 40J / cm 2 , at least 50J / cm 2 , at least 60J / cm 2 , at least 65J / cm 2 , at least 70J / cm 2 , at least 75J / cm 2 , at least 80J / cm 2 , at least 85J / cm 2 , at least 90J / cm 2 , at least 100J / cm 2 , at least 110J / cm 2 , at least 120J / cm 2 , at least 130J / cm 2 , at least 140J / cm 2 , at least 150J / cm 2 , at least 160J / cm 2 , at least 170J / cm 2 , at least 175J / cm 2 , at least 180J / cm 2 , at least 190J / cm 2 or at least 200 J / cm 2 In some embodiments, the near-infrared light source 170 has a radiation exposure (luminous flux) of, for example, at most 5 J / cm 2 , up to 10J / cm 2 , up to 15J / cm 2 , up to 20J / cm 2 , up to 30J / cm 2 , up to 40J / cm 2 , up to 50J / cm 2 , up to 60J / cm 2 , up to 65J / cm 2 , up to 70J / cm 2 , up to 75J / cm 2 , up to 80J / cm 2 , up to 85J / cm2 , up to 90J / cm 2 , up to 100J / cm 2 , up to 110J / cm 2 , up to 120J / cm 2 , up to 130J / cm 2 , up to 140J / cm 2 , up to 150J / cm 2 , up to 160J / cm 2 , up to 170J / cm 2 , up to 175J / cm 2 , up to 180J / cm 2 , up to 190J / cm 2 or up to 200 J / cm 2 In some embodiments, the near-infrared light source 170 has a radiation exposure (luminous flux) of, for example, about 5 J / cm 2 To about 10J / cm 2 , about 5J / cm 2 To about 15J / cm 2 , about 5J / cm 2 About 20J / cm 2 , about 5J / cm 2 About 30J / cm 2 , about 5J / cm 2 About 40J / cm 2 , about 5J / cm 2 To about 50J / cm 2 , about 5J / cm 2 To about 60J / cm 2 , about 5J / cm 2 To about 70J / cm 2 , about 5J / cm 2 To about 75J / cm 2 , about 5J / cm 2 To about 80J / cm 2 , about 5J / cm 2 To about 90J / cm 2 , about 5J / cm 2 To about 100 J / cm 2 , about 10J / cm 2 To about 15J / cm 2 , about 10J / cm 2 About 20J / cm 2 , about 10J / cm 2 About 30J / cm 2 , about 10J / cm 2 About 40J / cm2 , about 10J / cm 2 To about 50J / cm 2 , about 10J / cm 2 To about 60J / cm 2 , about 10J / cm 2 To about 70J / cm 2 , about 10J / cm 2 To about 75J / cm 2 , about 10J / cm 2 To about 80J / cm 2 , about 10J / cm 2 To about 90J / cm 2 , about 10J / cm 2 To about 100 J / cm 2 , about 20J / cm 2 About 30J / cm 2 , about 20J / cm 2 About 40J / cm 2 , about 20J / cm 2 To about 50J / cm 2 , about 20J / cm 2 To about 60J / cm 2 , about 20J / cm 2 To about 70J / cm 2 , about 20J / cm 2 To about 75J / cm 2 , about 20J / cm 2 To about 80J / cm 2 , about 20J / cm 2 To about 90J / cm 2 , about 20J / cm 2 To about 100 J / cm 2 , about 20J / cm 2 To about 110J / cm 2 , about 20J / cm 2 To about 120J / cm 2 , about 20J / cm 2 To about 130J / cm 2 , about 20J / cm 2 To about 140J / cm 2 , about 20J / cm 2 About 150 J / cm 2 , about 20J / cm 2 To about 160J / cm 2 , about 20J / cm 2 To about 170J / cm 2 , about 20J / cm2 To about 180J / cm 2 , about 20J / cm 2 To about 190J / cm 2 , about 20J / cm 2 About 200 J / cm 2 , about 30J / cm 2 About 40J / cm 2 , about 30J / cm 2 To about 50J / cm 2 , about 30J / cm 2 To about 60J / cm 2 , about 30J / cm 2 To about 70J / cm 2 , about 30J / cm 2 About 75J / cm 2 , about 30J / cm 2 To about 80J / cm 2 , about 30J / cm 2 To about 90J / cm 2 , about 30J / cm 2 To about 100 J / cm 2 , about 30J / cm 2 To about 110J / cm 2 , about 30J / cm 2 To about 120J / cm 2 , about 30J / cm 2 To about 130J / cm 2 , about 30J / cm 2 To about 140J / cm 2 , about 30J / cm 2 About 150 J / cm 2 , about 30J / cm 2 About 160J / cm 2 , about 30J / cm 2 About 170J / cm 2 , about 30J / cm 2 To about 180J / cm 2 , about 30J / cm 2 About 190J / cm 2 , about 30J / cm 2 About 200 J / cm 2 , about 40J / cm 2 To about 50J / cm 2 , about 40J / cm 2 To about 60J / cm 2 , about 40J / cm 2 To about 70J / cm2 , about 40J / cm 2 To about 75J / cm 2 , about 40J / cm 2 To about 80J / cm 2 , about 40J / cm 2 To about 90J / cm 2 , about 40J / cm 2 To about 100 J / cm 2 , about 40J / cm 2 To about 110J / cm 2 , about 40J / cm 2 To about 120J / cm 2 , about 40J / cm 2 To about 130J / cm 2 , about 40J / cm 2 To about 140J / cm 2 , about 40J / cm 2 About 150 J / cm 2 , about 40J / cm 2 To about 160J / cm 2 , about 40J / cm 2 To about 170J / cm 2 , about 40J / cm 2 About 180J / cm 2 , about 40J / cm 2 To about 190J / cm 2 , about 40J / cm 2 To about 200J / cm 2 , about 50J / cm 2 To about 60J / cm 2 , about 50J / cm 2 To about 70J / cm 2 , about 50J / cm 2 To about 75J / cm 2 , about 50J / cm 2 To about 80J / cm 2 , about 50J / cm 2 To about 90J / cm 2 , about 50J / cm 2 To about 100 J / cm 2 , about 50J / cm 2 To about 110J / cm 2 , about 50J / cm 2 To about 120J / cm 2 , about 50J / cm 2 To about 130J / cm 2 , about 50J / cm2 To about 140J / cm 2 , about 50J / cm 2 About 150 J / cm 2 , about 50J / cm 2 About 160J / cm 2 , about 50J / cm 2 About 170J / cm 2 , about 50J / cm 2 To about 180J / cm 2 , about 50J / cm 2 About 190J / cm 2 , about 50J / cm 2 About 200 J / cm 2 , about 60J / cm 2 To about 70J / cm 2 , about 60J / cm 2 To about 80J / cm 2 , about 60J / cm 2 To about 90J / cm 2 , about 60J / cm 2 To about 100 J / cm 2 , about 60J / cm 2 To about 110J / cm 2 , about 60J / cm 2 To about 120J / cm 2 , about 60J / cm 2 To about 130J / cm 2 , about 60J / cm 2 To about 140J / cm 2 , about 60J / cm 2 About 150 J / cm 2 , about 60J / cm 2 About 160J / cm 2 , about 60J / cm 2 About 170J / cm 2 , about 60J / cm 2 To about 180J / cm 2 , about 60J / cm 2 About 190J / cm 2 , about 60J / cm 2 About 200 J / cm 2 , about 70J / cm 2 To about 80J / cm 2 , about 70J / cm 2 To about 90J / cm 2 , about 70J / cm 2To about 100 J / cm 2 , about 80J / cm 2 To about 90J / cm 2 , about 80J / cm 2 To about 100 J / cm 2 or about 90J / cm 2 To about 100 J / cm 2 .

[0080] In some embodiments, one or more near infrared light sources 170 are each configured to emit about 100 J / cm 2 To about 1000J / cm 2 In some embodiments, the near-infrared light source 170 has a radiation exposure (luminous flux) of, for example, about 100 J / cm 2 , about 200J / cm 2 , about 300J / cm 2 , about 400J / cm 2 , about 500J / cm 2 , about 600J / cm 2 , about 700J / cm 2 , about 800J / cm 2 , about 900J / cm 2 or about 1000J / cm 2 In some embodiments, the near-infrared light source 170 has a radiation exposure (luminous flux) of at least 100 J / cm 2 , at least 200J / cm 2 , at least 300J / cm 2 , at least 400J / cm 2 , at least 500J / cm 2 , at least 600J / cm 2 , at least 700J / cm 2 , at least 800J / cm 2 , at least 900J / cm 2 or at least 1000J / cm 2 In some embodiments, the near-infrared light source 170 has a radiation exposure (luminous flux) of, for example, at most 100 J / cm 2 , up to 200J / cm 2 , up to 300J / cm 2 , up to 400J / cm 2 , up to 500J / cm 2 , up to 600J / cm 2 , up to 700J / cm 2 , up to 800J / cm2 , up to 900J / cm 2 or up to 1000J / cm 2 In some embodiments, the near-infrared light source 170 has a radiation exposure (luminous flux) of, for example, about 100 J / cm 2 To about 200J / cm 2 , about 100J / cm 2 To about 300J / cm 2 , about 100J / cm 2 To about 400J / cm 2 , about 100J / cm 2 To about 500J / cm 2 , about 100J / cm 2 To about 600J / cm 2 , about 100J / cm 2 To about 700J / cm 2 , about 100J / cm 2 To about 800J / cm 2 , about 100J / cm 2 To about 900J / cm 2 , about 100J / cm 2 To about 1000J / cm 2 , about 200J / cm 2 To about 300J / cm 2 , about 200J / cm 2 To about 400J / cm 2 , about 200J / cm 2 To about 500J / cm 2 , about 200J / cm 2 To about 600J / cm 2 , about 200J / cm 2 To about 700J / cm 2 , about 200J / cm 2 To about 800J / cm 2 , about 200J / cm 2 To about 900J / cm 2 , about 200J / cm 2 To about 1000J / cm 2 , about 300J / cm 2 To about 400J / cm 2 , about 300J / cm 2 To about 500J / cm 2 , about 300J / cm 2 To about 600J / cm 2 , about 300J / cm 2To about 700J / cm 2 , about 300J / cm 2 To about 800J / cm 2 , about 300J / cm 2 To about 900J / cm 2 , about 300J / cm 2 To about 1000J / cm 2 , about 400J / cm 2 To about 500J / cm 2 , about 400J / cm 2 To about 600J / cm 2 , about 400J / cm 2 To about 700J / cm 2 , about 400J / cm 2 To about 800J / cm 2 , about 400J / cm 2 To about 900J / cm 2 , about 400J / cm 2 To about 1000J / cm 2 , about 500J / cm 2 To about 600J / cm 2 , about 500J / cm 2 To about 700J / cm 2 , about 500J / cm 2 To about 800J / cm 2 , about 500J / cm 2 To about 900J / cm 2 , about 500J / cm 2 To about 1000J / cm 2 , about 600J / cm 2 To about 700J / cm 2 , about 600J / cm 2 To about 800J / cm 2 , about 600J / cm 2 To about 900J / cm 2 , about 600J / cm 2 To about 1000J / cm 2 , about 700J / cm 2 To about 800J / cm 2 , about 700J / cm 2 To about 900J / cm 2 , about 700J / cm 2 To about 1000J / cm 2 , about 800J / cm 2 To about 900J / cm 2, about 800J / cm 2 To about 1000J / cm 2 or about 900 J / cm 2 To about 1000J / cm 2 .

[0081] In some embodiments, the near-infrared light source 170 is a high-power infrared light source. In some embodiments, the high-power near-infrared light source has, for example, the following radiant flux (power): about 400mW, about 425mW, about 450mW, about 500mW, about 525mW, about 550mW, about 575mW, or about 600mW. In some embodiments, the high-power near-infrared light source has, for example, the following radiant flux (power): at least 400mW, at least 425mW, at least 450mW, at least 500mW, at least 525mW, at least 550mW, at least 575mW, or at least 600mW. In some embodiments, the high-power near-infrared light source has, for example, the following radiant flux (power): at most 400mW, at most 425mW, at most 450mW, at most 500mW, at most 525mW, at most 550mW, at most 575mW, or at most 600mW. In some embodiments, the high power near-infrared light source has a radiant flux (power), for example, of about 400 mW to about 450 mW, about 400 mW to about 500 mW, about 400 mW to about 550 mW, about 400 mW to about 600 mW, about 450 mW to about 500 mW, about 450 mW to about 550 mW, about 450 mW to about 600 mW, about 500 mW to about 550 mW, about 500 mW to about 600 mW, about 500 mW to about 550 mW, about 500 mW to about 600 mW, or about 550 mW to about 600 mW.

[0082] In some embodiments, the high-power near-infrared light source has, for example, a radiant flux (power) of about 100 mW, about 200 mW, about 300 mW, about 400 mW, about 500 mW, about 600 mW, about 700 mW, about 800 mW, about 900 mW, or about 1000 mW. In some embodiments, the high-power near-infrared light source has, for example, a radiant flux (power) of at least 100 mW, at least 200 mW, at least 300 mW, at least 400 mW, at least 500 mW, at least 600 mW, at least 700 mW, at least 800 mW, at least 900 mW, or at least 1000 mW. In some embodiments, the high-power near-infrared light source has, for example, a radiant flux (power) of at most 100 mW, at most 200 mW, at most 300 mW, at most 400 mW, at most 500 mW, at most 600 mW, at most 700 mW, at most 800 mW, at most 900 mW, or at most 1000 mW. In some embodiments, the high-power near-infrared light source has, for example, a radiant flux (power) of about 100 mW to about 200 mW, about 100 mW to about 300 mW, about 100 mW to about 400 mW, about 100 mW to about 500 mW, about 100 mW to about 600 mW, about 100 mW to about 700 mW, about 100 mW to about 800 mW, about 100 mW to about 900 mW, about 100 mW to about 1000 mW, about 200 mW to about 300mW, about 200mW to about 400mW, about 200mW to about 500mW, about 200mW to about 600mW, about 200mW to about 700mW, about 200mW to about 800mW, about 200mW to about 900mW, about 200mW to about 1000mW, about 300mW to about 400mW, about 300mW to about 500mW, about 300mW to about 600mW, about 300mW to about 700mW, about 200mW to about 800mW, about 200mW to about 900mW, about 200mW to about 1000mW, about 300mW to about 400mW, about 300mW to about 500mW, about 300mW to about 600mW, about 300mW to about 700mW, about 300mW to about about 800mW, about 300mW to about 900mW, about 300mW to about 1000mW, about 400mW to about 500mW, about 400mW to about 600mW, about 400mW to about 700mW, about 400mW to about 800mW, about 400mW to about 900mW, about 400mW to about 1000mW, about 500mW to about 600mW, about 500mW to about 700mW, about 500mW to about 800mW, about 400mW to about 900mW, about 400mW to about 1000mW, about 500mW to about 600mW, about 500mW to about 700mW, about 500mW to about 800mW, about 500mW to about W to about 900mW, about 500mW to about 1000mW, about 600mW to about 700mW, about 600mW to about 800mW, about 600mW to about 900mW, about 600mW to about 1000mW, about 700mW to about 800mW, about 700mW to about 900mW, about 700mW to about 1000mW, about 800mW to about 900mW, about 800mW to about 1000mW, or about 900mW to about 1000mW.

[0083] In some embodiments, the high power near infrared light source has a radiant flux (power) of, for example, about 500 mW, about 750 mW, about 1000 mW, about 1250 mW, about 1500 mW, about 1750 mW, about 2000 mW, about 2250 mW, about 2500 mW, about 2750 mW, about 3000 mW, about 3250 mW, about 3500 mW, about 3750 mW, about 4000 mW, about 4250 mW. mW, about 4500mW, about 4750mW, about 5000mW, about 5250mW, about 5500mW, about 5750mW, about 6000mW, about 6250mW, about 6500mW, about 6750mW, about 7000mW, about 7250mW, about 7500mW, about 7750mW, about 8000mW, about 8250mW, about 8500mW, about 8750mW or about 9000mW. In some embodiments, the high power near infrared light source has a radiant flux (power), for example, of at least 500 mW, at least 750 mW, at least 1000 mW, at least 1250 mW, at least 1500 mW, at least 1750 mW, at least 2000 mW, at least 2250 mW, at least 2500 mW, at least 2750 mW, at least 3000 mW, at least 3250 mW, at least 3500 mW, at least 3750 mW, at least 4000 mW, at least 4250 mW. W, at least 4500 mW, at least 4750 mW, at least 5000 mW, at least 5250 mW, at least 5500 mW, at least 5750 mW, at least 6000 mW, at least 6250 mW, at least 6500 mW, at least 6750 mW, at least 7000 mW, at least 7250 mW, at least 7500 mW, at least 7750 mW, at least 8000 mW, at least 8250 mW, at least 8500 mW, at least 8750 mW or at least 9000 mW. In some embodiments, the high power near infrared light source has a radiant flux (power) of, for example, at most 500 mW, at most 750 mW, at most 1000 mW, at most 1250 mW, at most 1500 mW, at most 1750 mW, at most 2000 mW, at most 2250 mW, at most 2500 mW, at most 2750 mW, at most 3000 mW, at most 3250 mW, at most 3500 mW, at most 3750 mW, at most 4000 mW. W, up to 4250mW, up to 4500mW, up to 4750mW, up to 5000mW, up to 5250mW, up to 5500mW, up to 5750mW, up to 6000mW, up to 6250mW, up to 6500mW, up to 6750mW, up to 7000mW, up to 7250mW, up to 7500mW, up to 7750mW, up to 8000mW, up to 8250mW, up to 8500mW,In some embodiments, the high power near infrared light source has a radiant flux (power) of, for example, about 500 mW to about 1000 mW, about 500 mW to about 1500 mW, about 500 mW to about 2000 mW, about 500 mW to about 2500 mW, about 500 mW to about 3000 mW, about 500 mW to about 3500 mW, about 500 mW to about 4000 mW, about 500 mW to about 4500 mW, about 500 mW to about 5000 mW, about 500 mW to about 5500 mW, about 500 mW to about 6000 mW, about 500 mW to about 6500 mW, about 500 mW to about 7000 mW, about 500 mW to about 7500 mW, about The present invention relates to a power supply of at least one embodiment of the present invention, wherein the power supply of the present invention is at least one embodiment of the present invention. The power supply of the present invention is preferably at least one embodiment of the present invention. The present invention relates to a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, a power supply having a power of at least about 1000 mW, 0mW, about 1000mW to about 7500mW, about 1000mW to about 8000mW, about 1000mW to about 8500mW, about 1000mW to about 9000mW, about 1500mW to about 2000mW, about 1500mW to about 2500mW, about 1500mW to about 3000mW, about 1500mW to about 3500mW, about 1500mW to about 4000mW, about 1500mW to about 4500mW, about 1500mW to about 5000mW, about 1500mW to about 5500mW, about 1500mW to about 6000mW, about 1500mW to about 6500mW, about 1500mW to about 7000mW,The power supply voltage is about 1500mW to about 7500mW, about 1500mW to about 8000mW, about 1500mW to about 8500mW, about 1500mW to about 9000mW, about 2000mW to about 2500mW, about 2000mW to about 3000mW, about 2000mW to about 3500mW, about 2000mW to about 4000mW, about 2000mW to about 4500mW, about 2000mW to about 5000mW, about 2000mW to about 5500mW, 0mW, about 2000mW to about 6000mW, about 2000mW to about 6500mW, about 2000mW to about 7000mW, about 2000mW to about 7500mW, about 2000mW to about 8000mW, about 2000mW to about 8500mW, about 2000mW to about 9000mW, about 2500mW to about 3000mW, about 2500mW to about 3500mW, about 2500mW to about 4000mW, about 2500mW to about 5000mW, about 2500mW to about 6000mW, about 2000mW to about 7500mW, about 2000mW to about 8000mW, about 2000mW to about 8500mW, about 2000mW to about 9000mW, about 4500mW, about 2500mW to about 5000mW, about 2500mW to about 5500mW, about 2500mW to about 6000mW, about 2500mW to about 6500mW, about 2500mW to about 7000mW, about 2500mW to about 7500mW, about 2500mW to about 8000mW, about 2500mW to about 8500mW, about 2500mW to about 9000mW, about 3000mW to about 3500mW, about 300 0mW to about 4000mW, about 3000mW to about 4500mW, about 3000mW to about 5000mW, about 3000mW to about 5500mW, about 3000mW to about 6000mW, about 3000mW to about 6500mW, about 3000mW to about 7000mW, about 3000mW to about 7500mW, about 3000mW to about 8000mW, about 3000mW to about 8500mW or about 3000mW to about 9000mW.

[0084] In some embodiments, the high-power near-infrared light source has a radiation intensity (brightness) of, for example, about 50 mW / sr, about 100 mW / sr, about 150 mW / sr, about 200 mW / sr, about 250 mW / sr, about 300 mW / sr, about 350 mW / sr, about 400 mW / sr, about 450 mW / sr, about 500 mW / sr, about 550 mW / sr, about 600 mW / sr, about 650 mW / sr, about 700 mW / sr, or about 750 mW / sr. In some embodiments, the high-power near-infrared light source has a radiation intensity (brightness) of, for example, at least 50 mW / sr, at least 100 mW / sr, at least 150 mW / sr, at least 200 mW / sr, at least 250 mW / sr, at least 300 mW / sr, at least 350 mW / sr, at least 400 mW / sr, at least 450 mW / sr, at least 500 mW / sr, at least 550 mW / sr, at least 600 mW / sr, at least 650 mW / sr, at least 700 mW / sr or at least 750 mW / sr. In some embodiments, the high-power near-infrared light source has a radiation intensity (brightness) of, for example, at most 50 mW / sr, at most 100 mW / sr, at most 150 mW / sr, at most 200 mW / sr, at most 250 mW / sr, at most 300 mW / sr, at most 350 mW / sr, at most 400 mW / sr, at most 450 mW / sr, at most 500 mW / sr, at most 550 mW / sr, at most 600 mW / sr, at most 650 mW / sr, at most 700 mW / sr or at most 750 mW / sr.In some embodiments, the high power near infrared light source has a brightness range (or radiant intensity) of, for example, about 50 mW / sr to about 100 mW / sr, about 50 mW / sr to about 150 mW / sr, about 50 mW / sr to about 200 mW / sr, about 50 mW / sr to about 300 mW / sr, about 50 mW / sr to about 400 mW / sr, about 50 mW / sr to about 500 mW / sr, about 50 mW / sr to about 600 mW / sr, about 50 mW / sr to about 700 mW / sr, about 50 mW / sr to about 800 mW / sr, about 100 mW / sr to about 150 mW / sr, about 100 mW / sr to about 150 mW / sr, about 100 mW / sr to about 200 mW / sr, about 50 mW / sr to about 300 mW / sr, about 50 mW / sr to about 400 mW / sr, about 50 mW / sr to about 500 mW / sr, about 50 mW / sr to about 600 mW / sr, about 50 mW / sr to about 700 mW / sr, about 50 mW / sr to about 800 mW / sr, about 100 mW / sr to about 150 mW / sr, about 100 mW / sr to about W / sr to about 200mW / sr, about 100mW / sr to about 300mW / sr, about 100mW / sr to about 400mW / sr, about 100mW / sr to about 500mW / sr, about 100mW / sr to about 600mW / sr, about 100mW / sr to about 700mW / sr, about 100mW / sr to about 800mW / sr, about 150mW / sr to about 200mW / sr, about 150mW / sr to about 300mW / sr, about 150mW / sr to about 400mW / sr, about 150mW / sr to about 500mW / sr, about 150mW / sr to about 600mW / sr, about 100mW / sr to about 700mW / sr, about 100mW / sr to about 800mW / sr, about 150mW / sr to about 200mW / sr, about 150mW / sr to about 300mW / sr, about 150mW / sr to about 400mW / sr, about 150mW / sr to about 500mW / sr, about 150mW / sr to about 600mW / sr sr, about 150mW / Sr to about 700mW / sr, about 150mW / Sr to about 800mW / sr, about 200mW / sr to about 300mW / sr, about 200mW / sr to about 400mW / sr, about 200m / sr to about 500mW / sr, about 200mW / sr to about 600mW / sr, about 200mW / sr to about 700mW / sr, about 200mW / sr to about 800mW / sr, about 300mW / sr to about 400mW / sr, about 300mW / sr to about 500mW / sr, about 300mW / sr to about 600mW / sr, about 300mW / sr to about To about 700mW / sr, about 300mW / sr to about 800mW / sr, about 400mW / sr to about 500mW / sr, about 400mW / sr to about 600mW / sr, about 400mW / sr to about 700mW / sr, about 400mW / sr to about 800mW / sr, about 500mW / sr to about 600mW / sr, about 500mW / sr to about 700mW / sr, about 500mW / sr to about 800mW / sr, about 600mW / sr to about 700mW / sr, about 600mW / sr to about 800mW / sr or about 700mW / sr to about 800mW / sr.

[0085] In some embodiments, the near-infrared light source 170 is a low-power infrared light source. In some embodiments, the low-power near-infrared light source has, for example, a radiant flux (power) of about 30 mW, about 35 mW, about 40 mW, about 45 mW, about 50 mW, about 55 mW, about 60 mW, about 65 mW, about 70 mW, or about 75 mW. In some embodiments, the low-power near-infrared light source has, for example, a radiant flux (power) of at least 30 mW, at least 35 mW, at least 40 mW, at least 45 mW, at least 50 mW, at least 55 mW, at least 60 mW, at least 65 mW, at least 70 mW, or at least 75 mW. In some embodiments, the low-power near-infrared light source has a radiant flux (power), for example, of at most 30 mW, at most 35 mW, at most 40 mW, at most 45 mW, at most 50 mW, at most 55 mW, at most 60 mW, at most 65 mW, at most 70 mW, or at most 75 mW. In some embodiments, the low power near infrared light source has a radiant flux (power), for example, of about 30 mW to about 40 mW, about 30 mW to about 50 mW, about 30 mW to about 60 mW, about 30 mW to about 70 mW, about 30 mW to about 75 mW, about 40 mW to about 50 mW, about 40 mW to about 60 mW, about 40 mW to about 70 mW, about 40 mW to about 75 mW, about 50 mW to about 60 mW, about 50 mW to about 70 mW, about 50 mW to about 75 mW, about 60 mW to about 70 mW, about 60 mW to about 75 mW.

[0086] In some embodiments, the low-power near-infrared light source is configured to have, for example, the following radiant intensity (brightness): about 25mW / sr, about 50mW / sr, about 75mW / sr, about 100mW / sr, about 125mW / sr, or about 150mW / sr. In some embodiments, the low-power near-infrared light source has, for example, the following brightness (or radiant intensity): at least 25mW / sr, at least 50mW / sr, at least 75mW / sr, at least 100mW / sr, at least 125mW / sr, or at least 150mW / sr. In some embodiments, the near-infrared light source 170 has, for example, the following radiant intensity (brightness): at most 25mW / sr, at most 50mW / sr, at most 75mW / sr, at most 100mW / sr, at most 125mW / sr, or at most 150mW / sr. In some embodiments, the low-power near-infrared light source has a radiation intensity (brightness) of, for example, about 25 mW / sr to about 50 mW / sr, about 25 mW / sr to about 75 mW / sr, about 25 mW / sr to about 100 mW / sr, about 25 mW / sr to about 125 mW / sr, about 25 mW / sr to about 150 mW / sr, about 50 mW / sr to about 75 mW / sr, about 50 mW / sr to about 100 mW / sr, about 25 mW / sr to about 125 mW / sr, about 25 mW / sr to about 150 mW / sr, about 50 mW / sr to about 75 mW / sr, about 50 mW / sr to about 100 mW / sr. / sr, about 50mW / sr to about 125mW / sr, about 50mW / sr to about 150mW / sr, about 75mW / sr to about 100mW / sr, about 75mW / sr to about 125mW / sr, about 75mW / sr to about 150mW / sr, about 100mW / sr to about 125mW / sr, about 100mW / sr to about 150mW / sr or about 125mW / sr to about 150mW / sr.

[0087] See also Figure 10-Figure 17 , Fig.21 and Fig.25, the photobiomodulation unit 100 also includes one or more sensors 180, which are configured to detect and collect information about one or more parameters to ensure normal use and efficacy, including operational information of the photobiomodulation therapy garment 20, biometric information of the user, or other useful information. Operational information includes, but is not limited to, location and security information of the photobiomodulation therapy garment 20. Biometric information includes, but is not limited to, body measurements and calculations related to the user. Non-limiting examples of biometric sensors include neural conductivity sensors, galvanometric sensors, oxygen level sensors, carbon dioxide level sensors, brain oxygen level sensors, heart rate sensors, cortical blood flow sensors, temperature sensors, electroencephalogram sensors, or any combination thereof. One or more sensors 180 can also measure, record, and analyze information and / or transmit information to the controller 200, which can measure, record, and analyze the information.

[0088] In one or more embodiments, Figure 3-Figure 5 , Fig.10 , Fig.12 , Fig.16 and Fig.17 As shown, the sensor cover 79 and the one or more sensors 180 located below or near it are positioned between the second near-infrared light source group 172 and the fifth near-infrared light source group 175. This position places the sensor cover 79 and the one or more sensors 180 located below it approximately on the sagittal plane 320 of the forehead area. In some embodiments (where the second near-infrared light source group 172 and / or the fifth near-infrared light source group 175 are not present), the sensor cover 79 and the one or more sensors 180 located below or near it can be positioned at a position on the photobiomodulation therapy headband 22 that is configured to place the sensor cover 79 approximately on top of the sagittal plane 320 when properly worn (see Figure 13-Figure 15 , Fig.18 , Fig.21 , Fig. 22 and Fig.25). In some embodiments, the sensor cover 79 and one or more sensors 180 located below or near it are positioned between the first near-infrared light source group 171 and the fourth near-infrared light source group 174. In some embodiments, the sensor cover 79 and one or more sensors 180 located below or near it are positioned between the third near-infrared light source group 173 and the sixth near-infrared light source group 176. In some embodiments (where the two sensors 180 need to be spaced apart to work properly), the sensor cover 79 and one or more sensors 180 located below or near it are positioned between the first near-infrared light source group 171 and the fourth near-infrared light source group 174 (or outside these groups in the direction toward the left side portion 56), and the sensor cover 79 and one or more sensors 180 located below or near it are positioned between the third near-infrared light source group 173 and the sixth near-infrared light source group 176 (or outside these groups in the direction toward the right side portion 54).

[0089] In some embodiments, sensor 180 includes a heart rate sensor and a temperature sensor. Fig.10 and Figure 12-Figure 17 , Fig.21 and Fig.25 , one or more sensors 180 include a cardiovascular sensor 182 that detects blood pulse, oxygen level, and other cardiovascular characteristics. Fig.11 , Fig.11 1 is a longitudinal cross-section of the sensor mounting portion 142, and the cardiovascular sensor 182 includes LED light sources 184, 186 and a photodetector 188. Light from the LED light sources 184, 186 is irradiated on the blood vessels just below the skin surface S; and part of the reflected light is captured by the photodetector 188. The signal from the cardiovascular sensor 182 is transmitted to the controller 200 for determining the cardiovascular parameters of the user. Similarly, see Fig.10 and Figure 12-Figure 17 , Fig.21 and Fig.25 The one or more sensors 180 include a temperature sensor 192 that detects skin parameters, such as skin temperature, skin density, and skin opacity (color). Signals from the temperature sensor 192 are transmitted to the controller 200 for use in determining the skin parameters of the user.

[0090] The photobiomodulation unit 100 may optionally include one or more stimulators 194 configured to administer brain stimulation or inhibition signals. Non-limiting examples of stimulators include transcranial direct current stimulators and transcranial magnetic stimulators. A transcranial direct current stimulator is a component that can generate direct current for stimulating specific parts of the brain, including nerve cells. Such a current generating component can be used to administer transcranial direct current stimulation (tDCS) therapy. A transcranial magnetic stimulator is a component that can generate a magnetic field for stimulating nerve cells in the brain, for example, a magnetic material (electromagnet) that can be magnetized using an electric current. Such a magnetic field generating component can be used to administer transcranial magnetic stimulation (TMS) therapy. In some embodiments and see Fig.21 and Fig.25 , one or more stimulators 194 are operably mounted to an electronic circuit connector 162 or a sensor fluid conduit 158 ​​, which contains the electronic circuitry required to establish electrical communication between each of the one or more stimulators 194 and the connection terminal 160 .

[0091] See also Figure 1 , Figure 2 , Figure 7 , Figure 8 , Fig.19 , Fig.23 and Figure 27-Figure 31, the photobiomodulation therapy garment 20 also includes a controller 200. In one or more embodiments, the controller 200 includes a housing that encapsulates an input, a hardware processor, a memory, and an output, and may include one or more of each of these elements. In one or more example embodiments, the controller 200 may include a single-board computer, a system on a chip, or other similar and / or known computing devices or circuits. The input may include one or more USB connectors and / or short-range wireless devices (e.g., a Bluetooth module, a Wi-Fi module, or other wireless communication devices or systems) for communicating with an external computer (such as a smart phone, a desktop, a laptop, a tablet, other wearable computing devices, a server, etc.). The controller 200 may operate automatically or semi-automatically, or may read executable software instructions, codes, or other information from a memory or computer-readable medium, or may receive information or instructions from a user, from a healthcare provider, or from any other source logically connected to a computer or device (such as another networked computer, a server, or an artificial intelligence (AI) or machine learning system) through an input. In some embodiments, the controller 200 can be remotely accessed and operated by a third party individual (e.g., a healthcare worker) who can monitor the use of the photobiomodulation therapy garment, change its operating parameters, and / or collect data from the photobiomodulation therapy garment 20, thereby providing a remote digital healthcare platform that assists the user in receiving the most effective biomodulation therapy. In some embodiments, the controller 200 can be a "virtual controller" where the controller 200 accesses and operates the photobiomodulation therapy garment 20 through a cloud computing element by a healthcare provider or any other source logically connected to a computer or device (such as another networked computer or server or an AI or machine learning-based system). The controller 200 can be evaluated and operated by pre-programmed instructions and / or parameters, real-time instructions and / or parameters, or both.

[0092] The controller 200 is programmed to provide electrical signals that power each of the one or more near-infrared light sources 170, each of the one or more sensors 180, and each of the one or more stimulators 194. In addition, the controller 200 in one or more embodiments is a computing device that is programmed or configured to implement methods and algorithms that can operably control each of the one or more near-infrared light sources 170, each of the one or more sensors 180, and each of the one or more stimulators 194. For example, in some embodiments, the controller 200 can operably control one or more of the following items: the operation time of the one or more near-infrared light sources 170, the fluence level of the one or more near-infrared light sources 170, the irradiance level of the one or more near-infrared light sources 170, whether the one or more near-infrared light sources 170 are continuously operated or pulsed, which one or more of the one or more near-infrared light sources 170 are activated or deactivated, and a predetermined dose measurement level. Additionally, the controller 200 is operable to control each of the one or more sensors 180, and receive and analyze information collected from each of the one or more sensors 180. In some embodiments, the controller 200 is operable to control one or more of the following: the operating time of one or more stimulators 194, the power level of one or more stimulators 194, whether one or more stimulators 194 are operated continuously or in pulses, which one or more of the one or more stimulators 194 are activated or deactivated, or any combination thereof.

[0093] In some embodiments, and see Figure 26-Figure 28 , the controller 200 includes a housing including a front housing portion 202 and a rear housing portion 204, a control assembly 210, and a heat dissipation material 230. The outer surface of the front housing portion 202 includes an on-off button 206 and an indicator light window 208. The rear housing portion 204 includes a reversibly removable cover 205, which exposes a connection terminal 212 when the cover 205 is removed, and the connection terminal 212 includes a guide rail bracket 214 and a contact 216. The guide rail bracket 214 is configured to reversibly and securely engage with the terminal guide rail bracket 164 of the connection terminal 160 of the photobiomodulation therapy garment 20 when the user determines to attach the controller 200 to the photobiomodulation therapy garment 20. When the guide rail bracket 214 is securely engaged with the terminal guide rail bracket 164, the contact 216 of the guide rail bracket 214 is in direct contact with the contact of the terminal guide rail bracket 164 to establish electronic communication between the controller 200 and the photobiomodulation therapy garment 20. As shown in Fig.28 and Fig.30As seen in FIG. 1 , the front housing 202 and the rear housing 204 form a port, such as USB-A, USB-B, USB-C, micro-USB, and lightning, that can access a cable connector 228. The cable connector 228 is configured to connect to a power source to enable charging of a rechargeable battery.

[0094] The control assembly 210 includes a rechargeable power source and one or more printed circuit boards. Figure 29-Figure 31 As shown in , the control assembly 210 includes a rechargeable power source 220 that supplies the power required to operate the controller 200 and printed circuit boards 222, 222' that provide a substrate and housing for the circuits required to operate the various components of the controller 200. Power is supplied to the printed circuit boards 222, 222' via a power sensing component 218, which is configured to transfer power from the rechargeable power source to the printed circuit boards 222, 222'. In this exemplary embodiment, the connection terminal 210 is located on the rear surface of the printed circuit board 222, while the power sensing component 218, the system chip 223, the on / off switch 224, the cable connector 229, and the antenna 229 are each located on the front surface of the printed circuit board 222 in a manner that provides the electronic communication necessary for the connection terminal 212 to communicate with the terminal 160, and provides the electronic communication necessary for the operation of the system chip 223, the on / off switch 224, the cable connector 228, and the antenna 229. The light source 226 is located on a printed circuit board 222' which provides a substrate and housing for circuitry that provides the electronic communications necessary for the operation of the light source 226. The antenna 229 is configured to enable wireless communication between the controller 200 and another device.

[0095] See now Fig.28 During assembly of the controller 200, a heat sink material 230 (such as a copper film) is placed on the inner surface of the rear housing portion 204 in a manner that aligns the cutouts in the heat sink material 230 with the openings in the rear housing portion 204, whereby the contacts 216 of the control terminals 212 are accessible to the contacts 166 when assembled. The control assembly 210 is then secured to the rear housing portion 204 in an orientation that aligns the contacts 216 of the control terminals 212 with the cutouts in the heat sink material and the openings in the rear housing portion 204, and in a manner that aligns the on / off switch 224 with the on / off button 206, aligns the light source 226 with the indicator light window 208, and aligns the cable connector 228 with the port for the cable connector 228.

[0096] In some embodiments, the controller 200 is operable to instruct activation of one or more infrared light sources 170 on the left side of the midsagittal plane 320 and deactivation of one or more infrared light sources 170 on the right side of the midsagittal plane 320, or vice versa. In some embodiments, the controller 200 is operable to instruct activation of one or more infrared light sources 170 on the left and right side of the midsagittal plane 320, while activating one or more infrared light sources 170 on the left side of the midsagittal plane 320 at a higher irradiance level relative to one or more infrared light sources 170 on the right side of the midsagittal plane 320, or vice versa.

[0097] In some embodiments, the controller 200 uses information collected from each of the one or more sensors 180, information provided by the user, or information remotely input by a third party individual to dynamically adjust operating parameters of the photobiomodulation therapy garment 20. Such information input is then processed by the controller 200 relative to information stored in an operating database in one or more algorithms and based on analysis performed in comparing the collected or provided or input information to information stored in such a database using one or more algorithms, executable instructions provided by the controller 200 adjust operating parameters of: one or more near infrared light sources 170, each of the one or more sensors 180, and each of the one or more stimulators 194.

[0098] For example, during operation of the photobiomodulation therapy garment 20, the cardiovascular sensor 182 obtains cardiovascular parameters from the user and analyzes the input information relative to the cardiovascular parameters stored in the operational database to evaluate the actual cardiovascular parameters and adjust the operation of the photobiomodulation therapy garment 20 based on the therapy selected by the user or third party individual. In some embodiments, a decrease in heart rate variability detected by the cardiovascular sensor 182 and sent to the controller 200 may cause the controller 200 to provide executable instructions to optimize the pulse wave by increasing the frequency of light emitted from one or more near-infrared light sources 170 if the user or third party individual has selected alertness therapy. As an example, the initial pulse wave of the photobiomodulation therapy garment 20 may be set to 40 Hz, and based on the detected heart rate variability, the controller 200 will increase the frequency of light emitted from one or more near-infrared light sources 170 to 50 Hz. Continuous monitoring and analysis of heart rate variability by cardiovascular sensor 182 and controller 200 may result in the 50 Hz pulse wave setting being maintained or increased to 60 Hz or 70 Hz or higher in order to establish an appropriate pulse wave for vigilance therapy emitted from one or more near infrared light sources 170. This dynamic monitoring of heart rate variability by cardiovascular sensor 182 and controller 200 results in continuous adjustment of the pulse wave in order to achieve the optimal pulse wave for the selected vigilance therapy.

[0099] In some embodiments, an increase in heart rate variability detected by the cardiovascular sensor 182 and sent to the controller 200 may result in the controller 200 providing executable instructions to optimize the pulse wave by reducing the frequency of light emitted from one or more near-infrared light sources 170 if the user or third-party individual has selected a calmness or relaxation therapy. As an example, the initial pulse wave of the photobiomodulation therapy garment 20 may be set to 40 Hz, and based on the detected heart rate variability, the controller 200 may reduce the frequency of light emitted from one or more near-infrared light sources 170 to 30 Hz. Continuous monitoring and analysis of heart rate variability by the cardiovascular sensor 182 and controller 200 may result in the 30 Hz pulse wave setting remaining unchanged, or reduced to 10 Hz or 1 Hz, in order to establish an appropriate pulse wave for calmness or relaxation therapy emitted from one or more near-infrared light sources 170. This dynamic monitoring of heart rate variability by the cardiovascular sensor 182 and controller 200 may result in continuous adjustment of the pulse wave to achieve the optimal pulse wave for the selected calmness or relaxation therapy.

[0100] As another example, during operation of the photobiomodulation therapy garment 20, the skin sensor 192 obtains information about skin parameters from the user and analyzes the input information relative to skin information stored in the operational database to assess the actual skin parameters and adjust the operation of the photobiomodulation therapy garment 20 based on the therapy selected by the user or third party individual. In some embodiments, a decrease in skin temperature detected by the skin sensor 192 and sent to the controller 200 causes the controller 200 to provide executable instructions to optimize the skin temperature by increasing the irradiance of light emitted from one or more near infrared light sources 170 if the user or third party individual has selected alertness therapy. As an example, the initial irradiance of the photobiomodulation therapy garment 20 may be set to 250 mW / cm 2 , and based on the detected skin temperature, the controller 200 increases the irradiance of the light emitted from one or more near-infrared light sources 170 to 500 mW / cm 2 Continuous monitoring and analysis of skin temperature by skin sensor 192 and controller 200 can result in 500mW / cm 2 The irradiance setting remains the same or is increased to 750mW / cm 2 or 1000mW / cm 2 Or more, in order to establish the appropriate skin temperature for the alertness therapy. This dynamic monitoring of skin temperature by skin sensor 192 and controller 200 will result in continuous adjustment of irradiance to achieve the optimal skin temperature for the selected alertness therapy.

[0101] In some embodiments, an increase in skin temperature detected by skin sensor 192 and sent to controller 200 may result in controller 200 providing executable instructions to optimize skin temperature by reducing the irradiance of light emitted from one or more near infrared light sources 170, if the user or third party individual has selected sedation therapy or relaxation therapy. As an example, the initial irradiance of photobiomodulation therapy garment 20 may be set to 250 mW / cm 2 , and based on the detected skin temperature, the controller 200 reduces the irradiance of the light emitted from one or more near-infrared light sources 170 to 100 mW / cm 2 Continuous monitoring and analysis of skin temperature by skin sensor 192 and controller 200 can result in 125mW / cm 2 The irradiance setting remains unchanged or is reduced to 75mW / cm 2 or 25mW / cm 2Or lower, in order to establish the appropriate skin temperature for sedation therapy or relaxation therapy. This dynamic monitoring of skin temperature by skin sensor 192 and controller 200 will result in continuous adjustment of irradiance to achieve the optimal skin temperature for the selected sedation therapy or relaxation therapy.

[0102] In some embodiments, a decrease in skin temperature detected by the skin sensor 192 and sent to the controller 200 may cause the controller 200 to provide executable instructions to optimize the skin temperature by increasing the duty cycle of light emitted from one or more near-infrared light sources 170, if the user or third-party individual has selected alertness therapy. As an example, the initial duty cycle of the photobiomodulation therapy garment 20 may be set to 50%, and based on the detected skin temperature, the controller 200 may increase the duty cycle of light emitted from one or more near-infrared light sources 170 to 60%. Continuous monitoring and analysis of skin temperature by the skin sensor 192 and controller 200 may cause the 60% duty cycle setting to remain unchanged, or to be increased to 75% or higher, in order to establish an appropriate skin temperature for alertness therapy. This dynamic monitoring of skin temperature by the skin sensor 192 and controller 200 will result in continuous adjustment of the duty cycle to achieve the optimal skin temperature for the selected alertness therapy.

[0103] In some embodiments, an increase in skin temperature detected by the skin sensor 192 and sent to the controller 200 may result in the controller 200 providing executable instructions to optimize the skin temperature by reducing the duty cycle of light emitted from one or more near-infrared light sources 170, if the user or third-party individual has selected a calming therapy or a relaxing therapy. As an example, the initial duty cycle of the photobiomodulation therapy garment 20 may be set to 50%, and based on the detected skin temperature, the controller 200 may reduce the duty cycle of light emitted from one or more near-infrared light sources 170 to 40%. Continuous monitoring and analysis of skin temperature by the skin sensor 192 and the controller 200 may result in the 40% duty cycle setting remaining unchanged, or reduced to 25% or less, in order to establish an appropriate skin temperature for alertness therapy. This dynamic monitoring of skin temperature by the skin sensor 192 and the controller 200 will result in continuous adjustment of the duty cycle to achieve the optimal skin temperature for the selected calming therapy or relaxing therapy.

[0104] In some embodiments, a higher skin opacity (indicating skin with a higher melanin content) detected by the skin sensor 192 and sent to the controller 200 causes the controller 200 to provide executable instructions to optimize skin penetration by adjusting the wavelength or combination of wavelengths of light emitted from one or more near-infrared light sources 170 to provide optimal light penetration for the selected therapy. As an example, the initial wavelength of the photobiomodulation therapy garment 20 may be set to 900 nm, and based on the detected skin opacity, the controller 200 increases the wavelength of light emitted from one or more near-infrared light sources 170 to approximately 970 nm. Continuous monitoring and analysis of skin opacity by the skin sensor 192 and controller 200 may cause the wavelength setting to remain unchanged or to be increased to 1000 nm or higher to establish an appropriate wavelength for skin penetration for the selected therapy. This dynamic monitoring of skin opacity by the skin sensor 192 and controller 200 will result in continuous adjustment of the wavelength to achieve optimal skin penetration for the selected therapy.

[0105] In some embodiments, lower skin opacity (indicating skin with lower melanin content) detected by the skin sensor 192 and sent to the controller 200 causes the controller 200 to provide executable instructions to optimize skin penetration by adjusting the wavelength or combination of wavelengths of light emitted from one or more near-infrared light sources 170 to provide optimal light penetration for the selected therapy. As an example, the initial wavelength of the photobiomodulation therapy garment 20 may be set to 900 nm, and based on the detected skin opacity, the controller 200 may reduce the wavelength of light emitted from one or more near-infrared light sources 170 to approximately 810 nm. Continuous monitoring and analysis of skin opacity by the skin sensor 192 and the controller 200 may cause the wavelength setting to remain unchanged or to be reduced to 790 nm or lower in order to establish an appropriate wavelength for skin penetration for the selected therapy. This dynamic monitoring of skin opacity by the skin sensor 192 and the controller 200 will result in continuous adjustment of the wavelength to achieve optimal skin penetration for the selected therapy.

[0106] In some embodiments, a higher skin density (indicating a higher fat content of the skin) detected by the skin sensor 192 and sent to the controller 200 may cause the controller 200 to provide executable instructions to optimize skin penetration by adjusting the wavelength of light emitted from one or more near-infrared light sources 170 to provide optimal light penetration for the selected therapy. As an example, the initial wavelength of the photobiomodulation therapy garment 20 may be set to 900 nm, and based on the detected density of the skin, the controller 200 may increase the wavelength of light emitted from one or more near-infrared light sources 170 to approximately 970 nm. Continuous monitoring and analysis of skin density by the skin sensor 192 and controller 200 may cause the wavelength setting to remain the same, or to be increased to 1000 nm or more, in order to establish an appropriate wavelength for skin penetration for the selected therapy. This dynamic monitoring of skin density by the skin sensor 192 and controller 200 will result in continuous adjustment of the wavelength to achieve optimal skin penetration for the selected therapy.

[0107] In some embodiments, a lower skin density (indicating skin with lower fat content) detected by the skin sensor 192 and sent to the controller 200 causes the controller 200 to provide executable instructions to optimize skin penetration by adjusting the wavelength of light emitted from one or more near-infrared light sources 170 to provide optimal light penetration for the selected therapy. As an example, the initial wavelength of the photobiomodulation therapy garment 20 may be set to 900 nm, and based on the detected skin density, the controller 200 may reduce the wavelength of light emitted from one or more near-infrared light sources 170 to approximately 810 nm. Continuous monitoring and analysis of skin density by the skin sensor 192 and controller 200 may cause the wavelength setting to remain unchanged or to be reduced to 790 nm or lower to establish an appropriate wavelength for skin penetration for the selected therapy. This dynamic monitoring of skin density by the skin sensor 192 and controller 200 will result in continuous adjustment of the wavelength to achieve optimal skin penetration for the selected therapy.

[0108] As another example, during operation of the photobiomodulation therapy garment 20, information may be provided by the user or a third party individual, and the input information may be used directly to adjust the operation of the photobiomodulation therapy garment 20 based on the therapy selected by the user, or analyzed relative to user-defined or third party-defined information stored in an operational database to adjust the operation of the photobiomodulation therapy garment 20 based on the selected therapy. As an example, the initial therapy of the photobiomodulation therapy garment 20 may be set to alertness therapy, and based on the user's input (e.g., "still tired" or "feel good") or the third party individual's input (based on, for example, monitoring of the user's physiological or vital signs), the controller 200 may adjust the characteristics of the light emitted from one or more near infrared light sources 170. Continuous user or third party individual input to the controller 200 will establish appropriate light characteristics for the selected alertness therapy. This dynamic monitoring of the user or third party individual input to the controller 200 will result in continuous adjustment of the light characteristics to achieve the optimal effect of the selected alertness therapy. As another example, where the treatment is a prescription therapy, instructions may be provided by a third party individual activating the photobiomodulation therapy garment 20 and scheduling parameters of the treatment, such as average irradiance, peak irradiance, average luminous flux, peak luminous flux, total energy incident during the treatment session, total power over the treatment area, duration of the treatment session, wave mode of pulsed or continuous operation, duty cycle, exposure area, frequency of multiple treatments, or any combination thereof. In this example, the user need only wear the photobiomodulation therapy garment 20 at the appropriate time and place.

[0109] As another example, during operation of the photobiomodulation therapy garment 20, the sensor 180 obtains information about mitochondrial function from the user and analyzes the input information relative to the mitochondrial function information stored in the operational database to assess actual mitochondrial function and adjust the operation of the photobiomodulation therapy garment 20 based on the therapy personally selected by the user or a third party. As an example, the initial therapy of the photobiomodulation therapy garment 20 can be set to alertness therapy, and based on the detected mitochondrial function (e.g., NAD + or NADH levels), the controller 200 will adjust the characteristics of the light emitted from the one or more near infrared light sources 170. Continuous monitoring and analysis of skin opacity by the sensor 180 and controller 200 will establish appropriate light characteristics for the selected alertness therapy emitted from the one or more near infrared light sources 170. This dynamic monitoring of mitochondrial function by the sensor 180 and controller 200 will result in continuous adjustment of the light characteristics to achieve optimal skin penetration of the selected alertness therapy.

[0110] The adjustments made by the controller 200 and described in the examples of the above paragraphs and the processing performed therein on various types of information can be performed in conjunction with a machine learning-based framework that applies elements of artificial intelligence (AI) to analyze information provided as input within a model trained on historical or known data (such as data stored in the above-mentioned operational database) to improve such adjustments to the operating parameters of the following items: one or more near-infrared light sources 170, each of the one or more sensors 180, and each of the one or more stimulators 194. Therefore, the present invention may include such a machine learning-based framework that can include multiple elements that perform several processing aspects performed by the controller 200 together or as separately instantiated models.

[0111] Modeling performed within a machine learning based framework may include many different types of machine learning and apply many different mathematical methods to analyze information and generate outputs that improve the results of continuous adjustments to the operating parameters of: one or more near infrared light sources 170, each of the one or more sensors 180, and each of the one or more stimulators 194 described herein. For example, in some embodiments of the invention, the machine learning based framework may include algorithms that apply techniques of supervised learning, reinforcement learning, and other methods of machine learning and artificial intelligence to further evaluate the inputs to the controller 200.

[0112] The framework based on machine learning can include any of several different mathematical methods. These mathematical methods can include statistical analysis, which is a non-deterministic mathematical method that can calculate the probability of an event occurring or not occurring. Regression analysis is a type of statistical analysis in which a model is used to estimate the relationship between variables of interest (e.g., a dependent variable and one or more independent variables (commonly referred to as "predictors")). This type of machine learning is used to infer the causal relationship between independent and dependent variables and to predict and forecast results, where this causal relationship has an impact on the future state of the application of the overall modeling being performed. There are many types of regression analysis (such as linear and nonlinear regression) and specific methods (such as logistic regression) that can use derived parameters to explain the importance of the maximum value in the form of log-odds when calculating probability values. For example, other types of logistic functions and other types of regression analysis can also be used to calculate the probability in the present invention, and are within the scope of the present invention. Other methods that can be used include, but are not limited to, decision trees, random forest classifiers, support vector machines, and probits. Therefore, it should be further understood that the present invention and this specification are not limited to any type of mathematical model or statistical process mentioned herein, particularly with respect to its application in one or more layers of machine learning.

[0113] Modeling within a machine learning-based framework can also include the application of neural networks. A neural network generally includes a node, which is a computational unit with one or more biased input / output connections. Such biased connections act as a transfer (or activation) function that combines input quantities and output quantities in some way. The nodes are organized into multiple layers that form a neural network. There are many types of neural networks, which are computing systems that "learn" to perform tasks based on examples, without being programmed with task-specific rules.

[0114] Neural networks are generally based on an array of connected, clustered nodes (or "neurons") that transmit signals to each other through biased input / output connections in multiple layers. As mentioned above, the connections are activation or transfer functions that "fire" these nodes and combine the inputs according to a mathematical equation or formula. Different types of neural networks generally have different configurations of these connected, clustered node layers, but they can generally be described as input layers, intermediate or "hidden" layers, and output layers. These layers can perform different transformations on their various inputs using different mathematical calculations or functions.

[0115] Signals are transmitted between nodes through connections, and the output of each node is calculated using a nonlinear function that adds up all the inputs to that node. Weight matrices and biases are typically applied to each node and each connection, and these weights and biases are adjusted as the neural network processes inputs and transmits them through nodes and connections. These weights represent an increase or decrease in signal strength at a particular connection. In addition, nodes can have thresholds so that a signal is sent only when the aggregate output at that node exceeds the threshold. Weights generally represent how long an activation function takes, while biases represent when such functions begin; together they help minimize gradients over time. At least in the case of weights, they can be initialized and change (i.e., decay) over time as the system learns what the weights should be and how they should be adjusted. In other words, neural networks evolve as they learn, and the mathematical formulas and functions that comprise the design of a neural network can change over time as the system improves itself.

[0116] The application of neural networks within a machine learning-based framework can include instantiations of different networks for different purposes. This includes "production" neural networks (which are configured to improve the algorithm executed within the overall modeling framework to generate output data (e.g., as adjusted operating parameters of one or more near-infrared light sources 170, each of one or more sensors 180, and each of one or more stimulators 194)) and "training" neural networks (which are configured to train production networks using improvements to the causes of learned previous historical results).

[0117] Recurrent Neural Networks is the name of a type of neural network in which the connections between nodes follow a directed time sequence, which allows the neural network to model temporal dynamic behavior and process input sequences of variable length. These types of neural networks are deployed wherever there is a need to recognize and / or act on such sequences. As with neural networks in general, there are many types of recurrent neural networks.

[0118] Neural networks with recurrent architectures may also have stored or controlled internal states that allow for storage under the direct control of the neural network, making them more suitable for inputs that are temporal in nature. Such storage may take the form of connections or gates for time delays or feedback loops that allow nodes or connections to retain data that precedes in time the modeling of such temporal dynamic behavior. Such controlled internal states are called gated states or gated memories and are part of Long Short Term Memory Networks (LSTM) and Gated Recurrent Units (GRU), which are names for different types of recurrent neural network architectures. This type of neural network is designed for situations where the desired output of the system is motivated by the need for memory as a storage device and, as mentioned above, the system is designed to process inputs that include timed data sequences. Examples of such timed data sequences include video, speech recognition, and handwriting, where the processing requires analysis of data that changes instantaneously. In the present invention, where the output data takes the form of operating parameters of one or more near-infrared light sources 170, each of one or more sensors 180, and each of one or more stimulators 194, understanding the effects of various events on the state over a period of time results in more accurate and reliable operating parameters, which can at least affect the amount of time that stimulation is provided.

[0119] There are many other types of recurrent neural networks. These include, for example, fully recurrent neural networks, Hopfield networks, bidirectional associative memory networks, echo state networks, neural Turing machines, and many other networks, all of which exhibit the ability to model temporal dynamic behavior. Any instantiation of such a neural network in the present invention may include one or more of these types, and it should be understood that the neural networks applied within a machine learning-based framework may include neural networks different from these types. Therefore, the present invention contemplates that many types of neural networks may be implemented, depending at least on the type of problem being analyzed.

[0120] The controller 200 is reversibly connected to the photobiomodulation therapy garment 20 by operably engaging the terminal rail bracket 164. The controller 200 may optionally include a rechargeable battery located within the housing. The controller 200 can be removed from the terminal rail bracket 164 for charging the rechargeable battery therein using a charging connector such as USB-C, micro-USB, etc. In addition, the charging connector can provide wired data communication with a remote computer (such as a smart phone, laptop, desktop or other computer device). In one or more embodiments, this enables tracking of usage and / or updating or changing operating parameters (such as desired dosimetry values, duration, adjusting the wave mode to pulsed or continuous operation, etc.) and / or updating controller firmware and / or changing the type of photobiomodulation therapy garment 20 to which the controller 200 will be attached. The controller 200 can be a universal controller such that the controller 200 can be connected to multiple embodiments of the photobiomodulation therapy garment 20, such as the photobiomodulation therapy headband 22, the neck region garment, the back of the neck region garment, the shoulder region garment, the wrist region garment, the abdomen region garment, the back region garment, etc., each of which is configured to cover their corresponding area when worn.

[0121] One or more near-infrared light sources 170 of the photobiomodulation unit 100 can be positioned as one or more individual near-infrared light source groups arranged in a plurality of intergroup patterns relative to each other and located on one or more regions of interest in the skin area S to be treated by photobiomodulation therapy. For example, there may be, for example, one near-infrared light source group, two near-infrared light source groups, three near-infrared light source groups, four near-infrared light source groups, five near-infrared light source groups, six near-infrared light source groups, seven near-infrared light source groups, eight near-infrared light source groups, nine near-infrared light source groups, or ten near-infrared light source groups. Each near-infrared light source group is spaced apart from an adjacent group, wherein the intergroup spacing between each near-infrared light source group may be the same, or may vary depending on a desired dose measurement value, as well as depending on the relative position of the desired region of interest. The relative pattern of the near-infrared light source groups is configured to position each group on the photobiomodulation therapy garment 20 to at least partially cover their corresponding regions of interest on the skin surface S, which may appear to be a random pattern to a casual observer. Figure 4As shown, the spacing of the inter-group pattern between each near-infrared light source group can be defined by the column distance d1 and the row distance d2. The inter-group distance can be measured from the center of the light source. In one or more embodiments, the column distance d1 and the row distance d2 are at least 5 mm, or at least 10 mm, or at least 15 mm, or at least 20 mm, or at least 25 mm, or at least 30 mm, or at least 35 mm, or at least 40 mm. In a rectangular array, the row distance d2 can be the same distance as the column distance d1, or it can be different from the column distance d1.

[0122] In some embodiments, the one or more skin regions S effectively covered by the group pattern of one or more near-infrared light sources 170 include, for example, a total area of ​​about 10 cm 2 、Approx. 15cm 2 、About 20cm 2 、Approx. 25cm 2 、About 30cm 2 、Approx. 35cm 2 、Approx. 40cm 2 、Approx. 45cm 2 、About 50cm 2 、Approx. 55cm 2 or about 60cm 2 In some embodiments, the one or more skin regions S effectively covered by the group pattern of one or more near-infrared light sources 170 include, for example, a total area of ​​at least 10 cm 2 , at least 15cm 2 , at least 20cm 2 , at least 25cm 2 , at least 30cm 2 , at least 35cm 2 , at least 40cm 2 , at least 45cm 2 , at least 50cm 2 , at least 55cm 2 or at least 60cm 2 In some embodiments, the one or more skin regions S effectively covered by the group pattern of one or more near-infrared light sources 170 include, for example, a total area of ​​at most 10 cm 2 , up to 15cm 2 , up to 20cm 2 , up to 25cm 2 , up to 30cm 2 , up to 35cm 2 , up to 40cm 2 , up to 45cm 2 , up to 50cm 2 , up to 55cm2 or up to 60cm 2 In some embodiments, the one or more skin regions S effectively covered by the group pattern of one or more near-infrared light sources 170 include, for example, a total area of ​​about 10 cm 2 To about 15cm 2 , about 10cm 2 To about 20cm 2 , about 10cm 2 To about 25cm 2 , about 10cm 2 About 30cm 2 , about 10cm 2 To about 35cm 2 、10cm 2 To about 40cm 2 , about 10cm 2 To about 45cm 2 , about 10cm 2 To about 50cm 2 , about 10cm 2 To about 55cm 2 , about 10cm 2 About 60cm 2 、Approx. 15cm 2 To about 20cm 2 、Approx. 15cm 2 To about 25cm 2 、Approx. 15cm 2 About 30cm 2 、Approx. 15cm 2 To about 35cm 2 、Approx. 15cm 2 To about 40cm 2 、Approx. 15cm 2 To about 45cm 2 、Approx. 15cm 2 To about 50cm 2 、Approx. 15cm 2 To about 55cm 2 、Approx. 15cm 2 About 60cm 2 、About 20cm 2 To about 25cm 2 、About 20cm 2 About 30cm 2 、About 20cm 2 To about 35cm 2 、About 20cm 2 To about 40cm 2 、About 20cm 2 To about 45cm 2、About 20cm 2 To about 50cm 2 、About 20cm 2 To about 55cm 2 、About 20cm 2 About 60cm 2 、Approx. 25cm 2 About 30cm 2 、Approx. 25cm 2 To about 35cm 2 、Approx. 25cm 2 To about 40cm 2 、Approx. 25cm 2 To about 45cm 2 , about 25cm2 to about 50cm 2 、Approx. 25cm 2 To about 55cm 2 、Approx. 25cm 2 About 60cm 2 、About 30cm 2 To about 35cm 2 、About 30cm 2 To about 40cm 2 、About 30cm 2 To about 45cm 2 、About 30cm 2 To about 50cm 2 、About 30cm 2 To about 55cm 2 、About 30cm 2 About 60cm 2 、Approx. 35cm 2 To about 40cm 2 、Approx. 35cm 2 To about 45cm 2 、Approx. 35cm 2 To about 50cm 2 、Approx. 35cm 2 To about 55cm 2 、Approx. 35cm 2 About 60cm 2 、Approx. 40cm 2 To about 45cm 2 、Approx. 40cm 2 To about 50cm 2 、Approx. 40cm 2 To about 55cm 2 、Approx. 40cm 2 About 60cm 2 、Approx. 45cm 2 To about 50cm 2 、Approx. 45cm 2 To about 55cm2 、Approx. 45cm 2 About 60cm 2 、Approx. 50cm 2 To about 55cm 2 、Approx. 50cm 2 About 60cm 2 or about 55cm 2 About 60cm 2 .

[0123] In some embodiments, the photobiomodulation unit 100 of the photobiomodulation therapy garment 20 includes one or more near-infrared light source groups. Each of the one or more near-infrared light source groups is positioned in a pattern that is configured to direct each light source to a specific area of ​​interest when the photobiomodulation therapy garment 20 is properly positioned on the forehead of the person P. In some embodiments, the photobiomodulation unit 100 includes one or more near-infrared light source groups that are positioned so that when the photobiomodulation therapy garment 20 is properly worn, each of the one or more near-infrared light source groups is positioned in a manner that at least partially overlaps or is approximately centered on a primary acupuncture meridian, a major extraordinary vessel, a minor extraordinary vessel, or any combination thereof. The major acupuncture meridians include, but are not limited to, the heart meridian, the pericardium meridian, the lung meridian, the spleen meridian, the liver meridian, the kidney meridian, the small intestine meridian, the large intestine meridian, the triple burner meridian, the stomach meridian, the foot Shaoyang gallbladder meridian, and the foot Taiyang bladder meridian. The major extraordinary meridians include, but are not limited to, the conception meridian and the governor meridian. The minor extraordinary meridians are the Chong Meridian, the Dai Meridian, the Yin Wei Meridian, the Yin Qiao Meridian, the Yang Wei Meridian and the Yang Qiao Meridian.

[0124] In some embodiments, and as Figure 4 , Fig.10 , Fig.12 , Fig.13 , Fig.16 and Fig.17 As shown, the photobiomodulation unit 100 includes six near-infrared light source groups, namely, a first near-infrared light source group 171, a second near-infrared light source group 172, a third near-infrared light source group 173, a fourth near-infrared light source group 174, a fifth near-infrared light source group 175, and a sixth near-infrared light source group 176. In some embodiments, and referring to Figure 4 , Fig.16 , Fig.17 , and see Fig.10 and Fig.12, the near-infrared light source groups 171, 172, 173, 174, 175, 176 of the near-infrared light source 170 present on the photobiomodulation unit 100 are arranged in a rectangular array pattern of three columns and two rows, wherein each near-infrared light source group is separated by a column distance d1 and a row distance d2. In these embodiments, the near-infrared light source groups 171, 172, 173, 174, 175, 176 are positioned in such a pattern that the pattern is configured to direct each light source to a specific area of ​​interest when the photobiomodulation therapy headband 22 is properly positioned on the forehead of the person P. For example, in some embodiments, near-infrared light source groups 171, 172, 173, 174, 175, 176 are configured into the photobiomodulation therapy headband 22 so that when worn on the forehead of person P, the photobiomodulation therapy headband 22 is positioned approximately above the superciliary region 322 in the following manner: the first near-infrared light source group 171, the second near-infrared light source group 172, the third near-infrared light source group 173, the fourth near-infrared light source group 174, the fifth near-infrared light source group 175 and the sixth near-infrared light source group 176 are positioned at least above the eye sockets of person P. In some embodiments, each of the near-infrared light source groups 171, 172, 173, 174, 175, and 176 is positioned so that when the photobiomodulation therapy headband 22 is properly worn, the first near-infrared light source group 171 of the near-infrared light source 170 is located at a first position at least partially overlapping or approximately centered on the Fp1 site 300, the second near-infrared light source group 172 of the near-infrared light source 170 is located at a second position at least partially overlapping or approximately centered on the Fpz site 302, and the third near-infrared light source group 170 is located at a second position at least partially overlapping or approximately centered on the Fpz site 302. Source group 173 is located at a third position that is at least partially overlapping or roughly centered on Fp2 portion 304, the fourth near-infrared light source group 174 of the near-infrared light source 170 is located at a fourth position that is at least partially overlapping or roughly centered on F3 portion 306, the fifth near-infrared light source group 175 of the near-infrared light source 170 is located at a fifth position that is at least partially overlapping or roughly centered on Fz portion 308, and the sixth near-infrared light source group 176 of the near-infrared light source 170 is located at a sixth position that is at least partially overlapping or roughly centered on F4 portion 310.

[0125] In some embodiments, and as Fig.13As shown, the photobiomodulation unit 100 includes six near-infrared light source groups of near-infrared light sources 170, namely, a first near-infrared light source group 171, a second near-infrared light source group 172, a third near-infrared light source group 173, a fourth near-infrared light source group 174, a fifth near-infrared light source group 175, and a sixth near-infrared light source group 176. The six near-infrared light source groups are organized into two inverse triangles, wherein the first near-infrared light source group 171, the second near-infrared light source group 172, the third near-infrared light source group 173, and the fourth near-infrared light source group 174 are aligned in an upper row, and the fifth near-infrared light source group 175 and the sixth near-infrared light source group 176 are aligned in a lower row. The first near-infrared light source group 171 and the second near-infrared light source group 172 are positioned to cover an area including the parts F3 306 and Fz 308 of the head H, and the third light group 173 and the fourth light group 174 are positioned to cover an area including the parts Fz 308 and F4 310 of the head H. Fifth near infrared light source group 175 is positioned to cover an area including site Fp1 300, and sixth near infrared light source group 176 is positioned to cover an area including site Fp2 304. In these embodiments, one or more sensors 180 are positioned in the lower row, between fifth near infrared light source group 175 and sixth near infrared light source group 176.

[0126] In some embodiments, and as Fig.14 As shown, the photobiomodulation unit 100 includes five near-infrared light source groups of near-infrared light sources 170, namely, a first near-infrared light source group 171, a second near-infrared light source group 172, a third near-infrared light source group 173, a fourth near-infrared light source group 174, and a fifth near-infrared light source group 175. The first near-infrared light source group 171, the second near-infrared light source group 172, and the third near-infrared light source group 173 are aligned in an upper row, and the fourth near-infrared light source group 174 and the fifth near-infrared light source group 175 are aligned in a lower row, wherein the fourth near-infrared light source group 174 is located below the first near-infrared light source group 171, and the fifth near-infrared light source group 175 is located below the third near-infrared light source group 173. The first near-infrared light source group 171, the second near-infrared light source group 172, and the third near-infrared light source group 173 are positioned to cover an area including parts F3 306, Fz 308, and F4 310 of the head H. Fourth near infrared light source group 174 is positioned to cover an area including site Fp1 300, and fifth near infrared light source group 175 is positioned to cover an area including site Fp2 304. In these embodiments, one or more sensors 180 are positioned in the lower row and below second near infrared light source group 172 and between fourth near infrared light source group 174 and fifth near infrared light source group 175.

[0127] In some embodiments, and as Fig.15As shown, the photobiomodulation unit 100 includes three near-infrared light source groups of near-infrared light sources 170, namely, a first near-infrared light source group 171, a second near-infrared light source group 172, and a third near-infrared light source group 173. The first near-infrared light source group 171, the second near-infrared light source group 172, and the third near-infrared light source group 173 are arranged in a row and positioned to cover an area including parts F3 306, Fz 308, and F4 310 of the head H. In these embodiments, one or more sensors 180 are positioned below the second near-infrared light source group 172.

[0128] In some embodiments, and as Fig.21 As shown, the photobiomodulation unit 100 includes two near-infrared light source intergroups of near-infrared light sources 170, wherein each intergroup includes four near-infrared light sources 170 arranged in a 2x 2 pattern. The first intergroup is substantially centered on sites Fp1 300 and F3 306 and at least partially covers Fpz 302 and Fz 308, and the second intergroup is substantially centered on sites Fp2 304 and F4 310 and at least partially covers Fpz 302 and Fz 308. In these embodiments, one or more sensors 180 are positioned between the first near-infrared light source group and the second near-infrared light source group. In aspects of these embodiments, the photobiomodulation unit 100 includes two stimulators 194, wherein one stimulator 194 is substantially centrally positioned within the first infrared light source intergroup and the other stimulator 194 is substantially centrally positioned within the second infrared light source intergroup. In aspects of these embodiments, the stimulator 194 is a transcranial direct current stimulator.

[0129] In some embodiments, and as Fig.25 As shown, the photobiomodulation unit 100 includes four near-infrared light source intergroups of near-infrared light sources 170, wherein each intergroup includes five near-infrared light sources 170 arranged in a row of three and a row of two. The first intergroup and the second intergroup are substantially centered on sites Fp1 300 and F3 306 and at least partially cover Fpz 302 and Fz 308, and the third intergroup and the fourth intergroup are substantially centered on sites Fp2 304 and F4 310 and at least partially cover Fpz 302 and Fz 308. In these embodiments, one or more sensors 180 are positioned between the first and second near-infrared light source groups and the third and fourth near-infrared light source groups. In aspects of these embodiments, the photobiomodulation unit 100 includes two stimulators 194, wherein one stimulator 194 is substantially centrally positioned between the first and second infrared light source intergroups, and the other stimulator 194 is substantially centrally positioned between the third and fourth infrared light source intergroups. In aspects of these embodiments, stimulator 194 is a transcranial direct current stimulator.

[0130] In some embodiments, and as in Figure 12-Figure 17 , Fig.21 and Fig.25 As shown in , each near-infrared light source group includes a single near-infrared light source 170. For example, and as Figure 12-Figure 15 and Fig.17 As shown, each of the near-infrared light source groups 171, 172, 173, 174, 175, 176 of the photobiomodulation unit 100 includes a single-lamp near-infrared light source 170. In the embodiment where there is only a single-lamp near-infrared light source 170 in the near-infrared light source group, such near-infrared light source 170 is preferably a high-power near-infrared light source having a radiation intensity (brightness) range of about 150 mW / sr or more, more preferably about 250 mW / sr or more.

[0131] In some embodiments, each near-infrared light source group includes multiple near-infrared light sources 170. For example, Fig.10 and Fig.16 As shown, each of the near-infrared light source groups 171, 172, 173, 174, 175, 176 of the photobiomodulation unit 100 includes nine near-infrared light sources 170. In embodiments where there are multiple near-infrared light sources 170 in the near-infrared light source group, such near-infrared light sources 170 may all be low-power near-infrared light sources with a radiation intensity (brightness) range of 125 mW / sr or less. In other embodiments where there are multiple near-infrared light sources 170 in the near-infrared light source group, such near-infrared light sources 170 may all be a combination of high-power near-infrared light sources with a radiation intensity (brightness) range of about 150 mW / sr or more, more preferably about 250 mW / sr or more, and low-power near-infrared light sources with a radiation intensity (brightness) range of 125 mW / sr or less.

[0132] In addition, in an embodiment where the near-infrared light source group includes multiple near-infrared light sources 170, there is an intra-group spacing between each individual near-infrared light source 170 and the adjacent near-infrared light source 170 in the same group. The intra-group spacing of each near-infrared light source 170 in the near-infrared light intra-group may be the same between each individual near-infrared light source 170, or may vary according to the desired dose measurement value, and according to the relative position of the desired region of interest. In some embodiments, each individual near-infrared light source 170 of each near-infrared light source group is arranged in a pattern configured for the desired treatment effect (where each individual near-infrared light source 170 is random relative to other individual near-infrared light sources 170 in the same near-infrared light source group) and / or arranged in a pattern determined by a combination of factors including the desired treatment effect, cost, manufacturing capabilities, etc. The relative pattern of the near-infrared light source group is configured to position each near-infrared light source 170 on the photobiomodulation therapy garment 20 to at least partially cover their corresponding regions of interest on the skin surface S, which may appear to be a random pattern to a casual observer.

[0133] Each individual near-infrared light source 170 within the near-infrared light inner group is spaced apart from all other individual near-infrared light sources 170 within the same inner group by an intra-group light source spacing. Each near-infrared light source 170 in the near-infrared light inner group can be arranged in a pattern that matches the positions of multiple regions of interest on the skin surface S. Therefore, the resulting near-infrared light inner group can appear to be arranged in an irregular pattern corresponding to the positions of multiple regions of interest on the skin surface S, wherein each region of interest can be at least partially covered by the corresponding group at the same time. As a result, the inter-group spacing and relative position of each near-infrared light source 170 in the near-infrared light inner group can vary according to the position of the region of interest on the skin surface S.

[0134] In some embodiments, for example, Figure 4In the rectangular arrangement shown, the spacing between each near-infrared light source 170 in the near-infrared light inner group can be defined by the column spacing d3 and the row spacing d4. The intra-group spacing can be measured from the center of the near-infrared light source 170. In some embodiments, the column spacing d3 and the row spacing d4 are at least 2 mm, at least 3 mm, at least 4 mm, at least 5 mm, at least 6 mm, at least 7 mm, at least 8 mm, at least 9 mm, at least 10 mm, at least 12 mm, or at least 15 mm. In the rectangular array, the row spacing d3 can be the same distance as the column spacing d4, or it can be different from the column spacing d4. In this rectangular arrangement, each near-infrared light source 170 in the near-infrared light inner group is arranged in an n1×n2 array, where n1 and n2 each represent the number of individual near-infrared light sources 170 in rows and columns, respectively. For example, the infrared light inner group can be a 2×2 array, a 2×3 array, a 3×2 array, a 3×3 array, a 3×4 array, a 4×3 array, a 4×4 array, a 2×5 array, a 5×2 array, a 3×5 array, a 5×3 array, a 4×5 array, a 5×4 array, a 5×5 array, etc. In some embodiments, each near infrared light source 170 in the near infrared light inner group can be configured as a radial or circular array around a single circle or multiple concentric circles. In these embodiments, the inter-group spacing can be measured from the center of the light source.

[0135] In some embodiments, each near-infrared light source of the photobiomodulation therapy garment 20 is configured as a near-infrared light inner group including a plurality of near-infrared light sources 170 arranged in an inner group array. In some embodiments, the near-infrared light source groups 171, 172, 173, 174, 175, and 176 of the photobiomodulation therapy garment 20 are each configured as a near-infrared light inner group including a plurality of near-infrared light sources 170 arranged in an inner group array, wherein the first near-infrared light source group 171 includes a plurality of near-infrared light sources 170 arranged in a first near-infrared light inner group, the second near-infrared light source group 172 includes a plurality of near-infrared light sources 170 arranged in a second near-infrared light inner group, the third near-infrared light source group 173 includes a plurality of near-infrared light sources 170 arranged in a third near-infrared light inner group, the fourth near-infrared light source group 174 includes a plurality of near-infrared light sources 170 arranged in a fourth near-infrared light inner group, the fifth near-infrared light source group 175 includes a plurality of near-infrared light sources 170 arranged in a fifth near-infrared light inner group, and the sixth near-infrared light source group 176 includes a plurality of near-infrared light sources 170 arranged in a sixth near-infrared light inner group.

[0136] In some embodiments, and see Figure 4 , Fig.10 and Fig.13, the near-infrared light source groups 171, 172, 173, 174, 175, 176 of the photobiomodulation therapy headband 22 are each configured as a near-infrared light inner group, which includes nine near-infrared light sources 170 arranged in a 3×3 array of three columns and three rows. In this example, d3 is greater than d4, which can produce therapeutic benefits due to the combined and overlapping light patterns incident on the skin surface S surface and the globally arranged gaps or areas with less overlap of the light patterns. In the example embodiment shown, d3=6mm to 7mm, and d4=9mm to 10mm. The overlapping patterns of the incident light produce areas of different power levels incident on the skin surface S inside and around each array or group, with areas of maximum irradiance and light flux directly under each individual near-infrared light source 170, areas of less irradiance and light flux between closely positioned individual near-infrared light sources 170, and areas of minimum irradiance and light flux between individual near-infrared light sources 170 positioned farthest from each other. In addition, although each of the near-infrared light source groups 171, 172, 173, 174, 175, and 176 are each illustrated as having the same intra-group pattern, each intra-group pattern can be configured with a different pattern and a different number of individual near-infrared light sources 170, which can be determined based on the desired form of therapy and the dose measurement values ​​required for each region of interest.

[0137] In one or more embodiments, in operation, the near-infrared light source groups can all be activated by the controller 200 using the same operating parameters (e.g., all groups are activated at the same time, all groups are in pulse mode, and all groups have the same power setting). In one or more embodiments, in operation, the near-infrared light source groups can each be activated by the controller 200 with different operating parameters, wherein one or more selected groups can be activated, while other groups remain closed. In addition, in one or more embodiments, the controller 200 has the ability to control the power level and / or pulse / continuous operation of each near-infrared light source group independently of other near-infrared light source groups on the photobiomodulation therapy clothing 20. The available operating parameters have great flexibility. Not only can each individual near-infrared light group be operated separately, but each individual near-infrared light source 170 in each near-infrared light group can also be individually addressed and controlled using individual operating parameters. In this way, each individual near-infrared light source 170 can be individually addressed as a unit, so that each individual near-infrared light source 170 can be activated / turned on or deactivated / turned off independently of all other individual near-infrared light sources 170. Furthermore, in one or more embodiments, each individual near infrared light source 170 can be driven in a pulsed or continuous mode independently of all other individual near infrared light sources 170. Additionally, in one or more embodiments, each individual near infrared light source 170 can be driven using a power profile that is independent of all other individual light sources. In this way, multiple predefined patterns can be initiated by executable instructions from the controller 200, wherein the pattern of activated light sources can be changed according to the desired treatment effect and the location of the region of interest.

[0138] Watch now Fig. 9 , Fig.16 , Fig.17 , Fig. 20 and Fig.24 In some embodiments, the photobiomodulation therapy garment 20 is assembled by sandwiching the photobiomodulation unit 100 between the outer fabric sheet 40 and the inner fabric sheet 70. In some embodiments, and as Fig. 9 , Fig. 20 and Fig.24 As shown, the size and shape of the hot melt adhesive film 240 is determined to cover most or all of the flexible printed circuit board assembly 110, but does not cover the terminal guide bracket 164 of the connection terminal 160, which is positioned between the outer fabric sheet 40 and the photobiomodulation unit 100. In some embodiments, and as Fig.16 and Fig.17As shown, the liquid wire circuit assembly 150 is directly affixed to the outer fabric sheet 40, such as by using an adhesive or by being woven into the outer fabric sheet 40. In embodiments where the photobiomodulation unit 100 includes the flexible printed circuit board assembly 110, the photobiomodulation unit 100 is aligned with the outer fabric sheet 40 in a manner that allows the terminal rail brackets 164 of the connection terminals 160 to be inserted through the terminal rail mounting openings 58. In embodiments where the photobiomodulation unit 100 includes the liquid wire circuit assembly 150, the connection terminals 160 are affixed to the outer fabric sheet 40 during construction of the liquid wire circuit assembly 150 on the outer fabric sheet 40.

[0139] Still see Fig. 9 , Fig.16 , Fig.17 , Fig. 20 and Fig.24 Once the photobiomodulation unit 100 is positioned on the outer fabric sheet 40, a layer of double-sided tape 250 positioned between the photobiomodulation unit 100 and the inner fabric sheet 70 is sized and shaped to cover most or all of the photobiomodulation unit 100. The double-sided tape 250 includes one or more near-infrared light source openings 252 and one or more sensor openings 254, each of which is a cutout configured to provide clearance for their respective components so that the double-sided tape 250 does not interfere with the operation of the one or more near-infrared light sources 170 and the one or more sensors 180. If present, the sensor cover 79 is appropriately positioned over its corresponding sensor 180. Subsequently, the inner fabric sheet 70 is aligned with the outer fabric sheet 40 and the photobiomodulation unit 100, and positioned so that each of the one or more near-infrared light sources 170 and each of the one or more sensors 180 are appropriately positioned with their corresponding near-infrared light source openings 76 and sensor openings 78, thereby allowing these components to function properly. Subsequently, the inner fabric sheet 70 may be secured to the outer fabric sheet 40 by sewing the edges 70 of the inner fabric sheet to the outer fabric sheet 40 .

[0140] In some embodiments, and as Fig. 20 and Fig.24 As shown in , the photobiomodulation unit 100 optionally includes a frame 260, a colloid 270, a heat dissipation material 280, or any combination thereof. The frame 260 provides structural support and protection to one or more near-infrared light sources 170, one or more sensors 180, and one or more stimulators 194. The colloid 270 is used as a pad to provide comfort to the user when wearing the photobiomodulation therapy garment disclosed herein. The heat dissipation material 280 is used to dissipate the heat generated by the one or more near-infrared light sources 170, one or more sensors 180, and one or more stimulators 194 during operation of the photobiomodulation therapy garment disclosed herein.

[0141] The photobiomodulation therapy clothing disclosed herein is used to provide photobiomodulation therapy. In some embodiments, the photobiomodulation therapy is transcranial photobiomodulation therapy. This non-invasive light-based neuromodulation therapy does not require drugs, and by providing various active photochemical reactions, it changes the working mode of the user's brain from the neuronal level upward, thereby providing long-term benefits. For example, photobiomodulation therapy can increase the production of mitochondrial energy and adenosine triphosphate (ATP) in neurons by enhancing the activity of cytochrome c oxidase. In addition, the transfer of light energy can also trigger the production of reactive oxygen species (ROS) (which can regulate inflammation at the cell and tissue levels and improve cell repair and healing) and the production of nitric oxide (NO) (which is essential for good vascular health and optimal blood flow, nutrient delivery and waste removal). This is important because insufficient cerebral blood flow and circulation can cause the brain to have fuzzy memory, forgetfulness, inattention and even dementia. Enhanced cellular energy and increased cerebral blood flow lead to increased neurogenesis and neuronal plasticity, improved neuroprotection, enhanced neural repair and reduced inflammation. Additionally, this photobiomodulation therapy provides calming and relaxing benefits, as well as improved focus and performance, thereby increasing mental productivity, mental well-being, and overall cognitive function.

[0142] The present specification discloses a method of improving cerebral blood flow in an individual using photobiomodulation therapy, the method comprising exposing a head region to infrared light of a photobiomodulation therapy garment disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include a forehead region, a temporal region, an occipital region, or any combination thereof.

[0143] In some embodiments, the disclosed method of improving cerebral blood flow comprises exposing a head region comprising, for example, an area of ​​about 10 cm 2 To about 15cm 2 , about 10cm 2 To about 20cm 2 , about 10cm 2 To about 25cm 2 , about 10cm 2 About 30cm 2 , about 10cm 2 To about 35cm 2 , about 10cm 2 To about 40cm 2 , about 10cm 2 To about 45cm 2 , about 10cm 2 To about 50cm 2 、Approx. 15cm 2 To about 20cm 2 、Approx. 15cm2 To about 25cm 2 、Approx. 15cm 2 About 30cm 2 、Approx. 15cm 2 To about 35cm 2 、Approx. 15cm 2 To about 40cm 2 、Approx. 15cm 2 To about 45cm 2 、Approx. 15cm 2 To about 50cm 2 、About 20cm 2 To about 25cm 2 、About 20cm 2 About 30cm 2 、About 20cm 2 To about 35cm 2 、About 20cm 2 To about 40cm 2 、About 20cm 2 To about 45cm 2 、About 20cm 2 To about 50cm 2 、Approx. 25cm 2 About 30cm 2 、Approx. 25cm 2 To about 35cm 2 、Approx. 25cm 2 To about 40cm 2 、Approx. 25cm 2 To about 45cm 2 、Approx. 25cm 2 To about 50cm 2 、About 30cm 2 To about 35cm 2 、About 30cm 2 To about 40cm 2 、About 30cm 2 To about 45cm 2 or about 30cm 2 To about 50cm 2 .

[0144] In some embodiments, the disclosed method for improving cerebral blood flow may include a single treatment course or multiple treatment courses. In various aspects of these embodiments, the disclosed method for improving cerebral blood flow includes, for example, about 1 to about 5 treatment courses, about 1 to about 10 treatment courses, about 1 to about 15 treatment courses, about 1 to about 20 treatment courses, about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses. In other aspects of these embodiments, the disclosed method for improving cerebral blood flow may include multiple treatment courses that last for months or years.

[0145] In some embodiments, the disclosed methods of improving cerebral blood flow include exposing a region of the head to infrared light for, e.g., about 5 minutes to about 10 minutes, about 5 minutes to about 15 minutes, about 5 minutes to about 20 minutes, about 5 minutes to about 25 minutes, about 5 minutes to about 30 minutes, about 5 minutes to about 35 minutes, about 5 minutes to about 40 minutes, about 10 minutes to about 15 minutes, about 10 minutes to about 20 minutes, about 10 minutes to about 25 minutes, about 10 minutes to about 30 minutes, about 10 minutes to about 35 minutes, about 10 minutes to about 40 minutes, about 15 minutes to about 20 minutes, about 15 minutes to about 25 minutes, about 15 minutes to about 30 minutes, about 15 minutes to about 35 minutes, or about 15 minutes to about 40 minutes, during a treatment course.

[0146] In some embodiments, the disclosed method of improving cerebral blood flow comprises infrared light having an average irradiance range of, for example, about 50 mW / cm 2 About 100mW / cm 2 , about 50mW / cm 2 to about 150mW / cm 2 , about 50mW / cm 2 About 200mW / cm 2 , about 50mW / cm 2 to about 250mW / cm 2 , about 50mW / cm 2 About 300mW / cm 2 , about 100mW / cm 2 to about 150mW / cm 2 , about 100mW / cm 2 About 200mW / cm 2 , about 100mW / cm 2 to about 250mW / cm2 , about 100mW / cm 2 About 300mW / cm 2 , about 150mW / cm 2 About 200mW / cm 2 , about 150mW / cm 2 to about 250mW / cm 2 , about 150mW / cm 2 About 300mW / cm 2 , about 200mW / cm 2 to about 250mW / cm 2 , about 200mW / cm 2 About 300mW / cm 2 or about 250mW / cm 2 About 300mW / cm 2 .

[0147] In some embodiments, the disclosed method of improving cerebral blood flow comprises infrared light comprising an average light flux of, for example, about 30 J / cm2 over a body region. 2 To about 50J / cm 2 , about 30J / cm 2 About 75J / cm 2 , about 30J / cm 2 To about 100 J / cm 2 , about 30J / cm 2 To about 125J / cm 2 , about 30J / cm 2 About 150 J / cm 2 , about 50J / cm 2 About 75J / cm 2 , about 50J / cm 2 To about 100 J / cm 2 , about 50J / cm 2 To about 125J / cm 2 , about 50J / cm 2 About 150 J / cm 2 , about 75J / cm 2 To about 100 J / cm 2 , about 75J / cm 2 To about 125J / cm 2 , about 75J / cm 2 About 150 J / cm 2 , about 100J / cm 2 To about 125J / cm 2 , about 100J / cm 2 About 150 J / cm2 or about 100 J / cm 2 About 150 J / cm 2 .

[0148] In some embodiments, the disclosed method of improving cerebral blood flow comprises infrared light comprising a total energy incident during the treatment process of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about from about 2.5 kJ, from about 1.0 kJ to about 3.0 kJ, from about 1.0 kJ to about 3.5 kJ, from about 1.0 kJ to about 4.0 kJ, from about 1.0 kJ to about 4.5 kJ, from about 1.0 kJ to about 5.0 kJ, from about 1.0 kJ to about 5.5 kJ, from about 1.0 kJ to about 6 kJ, from about 1.5 kJ to about 2.0 kJ, from about 1.5 kJ to about 2.5 kJ, from about 1.5 kJ to about 3.0 kJ, from about 1.5 kJ to about 3.5 kJ, from about 1.5 kJ to about 4.0 kJ, from about 1.5 kJ to about 4.5 kJ, from about 1.5 kJ to about 5.0 kJ, from about 1.5 kJ to about 5.5 kJ, from about 1.5 kJ to about 6 kJ, from about 2.0 kJ to about 2.5 kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, about From about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0149] In some embodiments, the disclosed method of improving cerebral blood flow comprises infrared light comprising a total power of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW on a body region. , about 1,000 mW to about 9,000 mW, about 2,000 mW to about 3,000 mW, about 2,000 mW to about 4,000 mW, about 2,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about 5 ,000mW, about 3,000mW to about 6,000mW, about 3,000mW to about 7,000mW, about 3,000mW to about 8,000mW, about 3,000mW to about 9,000mW, about 4,000mW to about 5,000mW, about 4,000mW to about 6,000mW, about 4,000mW to about 7,000mW, about 4,000mW to about 8,000mW, about 4,000mW to about 9,000mW, about 5,000mW to about The power supply voltage may be selected from the group consisting of: 1,000 mW to about 6,000 mW, 1,000 mW to about 7,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, or 1,000 mW to about 9,000 mW.

[0150] In various aspects of these embodiments, the disclosed method of improving cerebral blood flow comprises exposing a 2 To about 27cm 2 In other aspects of these embodiments, the disclosed method of improving cerebral blood flow includes infrared light including the following items: about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2, the total energy incident during the treatment process is about 0.5kJ to about 6kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for improving cerebral blood flow includes infrared light having a total power of about 900mW to about 8,100mW on the head area. In other aspects of these embodiments, the disclosed method for improving cerebral blood flow also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy garment disclosed herein.

[0151] In various aspects of these embodiments, the disclosed method of improving cerebral blood flow comprises exposing a cerebral blood flow comprising about 20 cm 2 To about 28cm 2 In other aspects of these embodiments, the disclosed method of improving cerebral blood flow includes infrared light including the following items: about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , the total energy incident during the treatment process is about 1.5kJ to about 3.5kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving cerebral blood flow includes infrared light having a total power of about 1,000mW to about 8,400mW on the head area. In other aspects of these embodiments, the disclosed method of improving cerebral blood flow also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of improving cerebral blood flow can comprise a single treatment session or multiple treatment sessions, e.g., about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0152] In various aspects of these embodiments, the disclosed method of improving cerebral blood flow comprises exposing a cerebral blood flow comprising about 22 cm 2 To about 26cm 2 In other aspects of these embodiments, the disclosed method of improving cerebral blood flow includes infrared light including the following items: about 250 mW / cm 2 To about 300mW / cm 2The average irradiance range is about 150 J / cm 2 About 200 J / cm 2 , the total energy incident during the treatment process is about 4kJ to about 5kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for improving cerebral blood flow includes infrared light having a total power of about 3,000mW to about 8,400mW on the head area. In other aspects of these embodiments, the disclosed method for improving cerebral blood flow also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be applied using the transcranial photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed method for improving cerebral blood flow can include a single treatment process or multiple treatment processes, such as about 2 to about 5 treatment processes, about 2 to about 10 treatment processes, about 2 to about 15 treatment processes, about 2 to about 20 treatment processes, about 5 to about 10 treatment processes, about 5 to about 15 treatment processes, about 5 to about 20 treatment processes, about 10 to about 15 treatment processes, about 10 to about 20 treatment processes, or about 15 to about 20 treatment processes.

[0153] The present specification discloses a method of treating depression in an individual using photobiomodulation therapy, the method comprising exposing a head region to infrared light of a photobiomodulation therapy garment disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include a forehead region, a temporal region, an occipital region, or any combination thereof.

[0154] In some embodiments, the disclosed methods of treating depression include exposing a head region including, for example, an area of ​​about 10 cm 2 To about 15cm 2 , about 10cm 2 To about 20cm 2 , about 10cm 2 To about 25cm 2 , about 10cm 2 About 30cm 2 , about 10cm 2 To about 35cm 2 , about 10cm 2 To about 40cm 2 , about 10cm 2 To about 45cm 2 , about 10cm 2 To about 50cm 2 、Approx. 15cm 2 To about 20cm 2 、Approx. 15cm 2 To about 25cm 2、Approx. 15cm 2 About 30cm 2 、Approx. 15cm 2 To about 35cm 2 、Approx. 15cm 2 To about 40cm 2 、Approx. 15cm 2 To about 45cm 2 、Approx. 15cm 2 To about 50cm 2 、About 20cm 2 To about 25cm 2 、About 20cm 2 About 30cm 2 、About 20cm 2 To about 35cm 2 、About 20cm 2 To about 40cm 2 、About 20cm 2 To about 45cm 2 、About 20cm 2 To about 50cm 2 、Approx. 25cm 2 About 30cm 2 、Approx. 25cm 2 To about 35cm 2 、Approx. 25cm 2 To about 40cm 2 、Approx. 25cm 2 To about 45cm 2 、Approx. 25cm 2 To about 50cm 2 、About 30cm 2 To about 35cm 2 、About 30cm 2 To about 40cm 2 、About 30cm 2 To about 45cm 2 or about 30cm 2 To about 50cm 2 .

[0155] In some embodiments, the disclosed methods for treating depression may include a single treatment course or multiple treatment courses. In various aspects of these embodiments, the disclosed methods for treating depression include, for example, about 1 to about 5 treatment courses, about 1 to about 10 treatment courses, about 1 to about 15 treatment courses, about 1 to about 20 treatment courses, about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses. In other aspects of these embodiments, the disclosed methods for treating depression may include multiple treatment courses that last for months or years.

[0156] In some embodiments, the disclosed methods of treating depression include exposing a region of the head to infrared light for, e.g., about 5 minutes to about 10 minutes, about 5 minutes to about 15 minutes, about 5 minutes to about 20 minutes, about 5 minutes to about 25 minutes, about 5 minutes to about 30 minutes, about 5 minutes to about 35 minutes, about 5 minutes to about 40 minutes, about 10 minutes to about 15 minutes, about 10 minutes to about 20 minutes, about 10 minutes to about 25 minutes, about 10 minutes to about 30 minutes, about 10 minutes to about 35 minutes, about 10 minutes to about 40 minutes, about 15 minutes to about 20 minutes, about 15 minutes to about 25 minutes, about 15 minutes to about 30 minutes, about 15 minutes to about 35 minutes, or about 15 minutes to about 40 minutes, during the course of treatment.

[0157] In some embodiments, the disclosed method of treating depression includes infrared light having an average irradiance range of, for example, about 50 mW / cm 2 About 100mW / cm 2 , about 50mW / cm 2 to about 150mW / cm 2 , about 50mW / cm 2 About 200mW / cm 2 , about 50mW / cm 2 to about 250mW / cm 2 , about 50mW / cm 2 About 300mW / cm 2 , about 100mW / cm 2 to about 150mW / cm 2 , about 100mW / cm 2 About 200mW / cm 2 , about 100mW / cm 2 to about 250mW / cm 2, about 100mW / cm 2 About 300mW / cm 2 , about 150mW / cm 2 About 200mW / cm 2 , about 150mW / cm 2 to about 250mW / cm 2 , about 150mW / cm 2 About 300mW / cm 2 , about 200mW / cm 2 to about 250mW / cm 2 , about 200mW / cm 2 About 300mW / cm 2 or about 250mW / cm 2 About 300mW / cm 2 .

[0158] In some embodiments, the disclosed method of treating depression includes infrared light including an average light flux of, for example, about 30 J / cm 2 To about 50J / cm 2 , about 30J / cm 2 About 75J / cm 2 , about 30J / cm 2 To about 100 J / cm 2 , about 30J / cm 2 To about 125J / cm 2 , about 30J / cm 2 About 150 J / cm 2 , about 50J / cm 2 About 75J / cm 2 , about 50J / cm 2 To about 100 J / cm 2 , about 50J / cm 2 To about 125J / cm 2 , about 50J / cm 2 About 150 J / cm 2 , about 75J / cm 2 To about 100 J / cm 2 , about 75J / cm 2 To about 125J / cm 2 , about 75J / cm 2 About 150 J / cm 2 , about 100J / cm 2 To about 125J / cm 2 , about 100J / cm 2 About 150 J / cm 2or about 100 J / cm 2 About 150 J / cm 2 .

[0159] In some embodiments, the disclosed methods of treating depression include infrared light including a total energy incident during the treatment process of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about 2.5 kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, about From about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0160] In some embodiments, the disclosed methods of treating depression include infrared light including a total power of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW, about 1,000 mW to about 9,000 mW, about 1,000 mW to about 10,000 mW, about 1,000 mW to about 11,000 mW, about 1,000 mW to about 12,000 mW, about 1,000 mW to about 13,000 mW, about 1,000 mW to about 14,000 mW, about 1,000 mW to about 15,000 mW, about 1,000 mW to about 16,000 mW, about 1,000 mW to about 17,000 mW, about 1,000 mW to about 18,000 mW, about 1 about 1,000 mW to about 9,000 mW, about 2,000 mW to about 3,000 mW, about 2,000 mW to about 4,000 mW, about 2,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about 5, The present invention relates to a power supply having a power of about 1000 mW, about 3,000 mW to about 6,000 mW, about 3,000 mW to about 7,000 mW, about 3,000 mW to about 8,000 mW, about 3,000 mW to about 9,000 mW, about 4,000 mW to about 5,000 mW, about 4,000 mW to about 6,000 mW, about 4,000 mW to about 7,000 mW, about 4,000 mW to about 8,000 mW, about 4,000 mW to about 9,000 mW, about 5,000 mW to about mW to about 6,000 mW, about 5,000 mW to about 7,000 mW, about 5,000 mW to about 8,000 mW, about 5,000 mW to about 9,000 mW, about 6,000 mW to about 7,000 mW, about 6,000 mW to about 8,000 mW, about 6,000 mW to about 9,000 mW, about 7,000 mW to about 8,000 mW, about 7,000 mW to about 9,000 mW, or about 8,000 mW to about 9,000 mW.

[0161] In various aspects of these embodiments, the disclosed method of treating depression comprises exposing a subject to a subject comprising about 18 cm 2 To about 27cm 2 In other aspects of these embodiments, the disclosed method for treating depression includes infrared light including the following items: about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2, the total energy incident during the treatment process is about 0.5kJ to about 6kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating depression includes infrared light having a total power of about 900mW to about 8,100mW on the head area. In other aspects of these embodiments, the disclosed method for treating depression also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be applied using the transcranial photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed method for treating depression can include a single treatment process or multiple treatment processes, such as about 2 to about 5 treatment processes, about 2 to about 10 treatment processes, about 2 to about 15 treatment processes, about 2 to about 20 treatment processes, about 5 to about 10 treatment processes, about 5 to about 15 treatment processes, about 5 to about 20 treatment processes, about 10 to about 15 treatment processes, about 10 to about 20 treatment processes, or about 15 to about 20 treatment processes.

[0162] In various aspects of these embodiments, the disclosed method of treating depression comprises exposing a subject to a 20 cm 2 To about 28cm 2 In other aspects of these embodiments, the disclosed method for treating depression includes infrared light including the following items: about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , the total energy incident during the treatment process is about 1.5 kJ to about 3.5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating depression includes infrared light having a total power of about 1,000 mW to about 8,400 mW on the head area. In other aspects of these embodiments, the disclosed method for treating depression also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be applied using the transcranial photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed method for treating depression can include a single treatment process or multiple treatment processes, such as about 2 to about 5 treatment processes, about 2 to about 10 treatment processes, about 2 to about 15 treatment processes, about 2 to about 20 treatment processes, about 5 to about 10 treatment processes, about 5 to about 15 treatment processes, about 5 to about 20 treatment processes, about 10 to about 15 treatment processes, about 10 to about 20 treatment processes, or about 15 to about 20 treatment processes.

[0163] In various aspects of these embodiments, the disclosed method of treating depression comprises exposing a subject to about 22 cm 2 To about 26cm 2 In other aspects of these embodiments, the disclosed method for treating depression includes infrared light including the following items: about 250 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 150 J / cm 2 About 200 J / cm 2 , the total energy incident during the treatment process is about 4kJ to about 5kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating depression includes infrared light having a total power of about 3,000mW to about 8,400mW on the head area. In other aspects of these embodiments, the disclosed method for treating depression also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be applied using the transcranial photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed method for treating depression can include a single treatment process or multiple treatment processes, such as about 2 to about 5 treatment processes, about 2 to about 10 treatment processes, about 2 to about 15 treatment processes, about 2 to about 20 treatment processes, about 5 to about 10 treatment processes, about 5 to about 15 treatment processes, about 5 to about 20 treatment processes, about 10 to about 15 treatment processes, about 10 to about 20 treatment processes, or about 15 to about 20 treatment processes.

[0164] The present specification discloses a method of treating autism in an individual using photobiomodulation therapy, the method comprising exposing a head region to infrared light of a photobiomodulation therapy garment disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include a forehead region, a temporal region, an occipital region, or any combination thereof.

[0165] In some embodiments, the disclosed methods of treating autism include exposing a head region including, for example, an area of ​​about 10 cm 2 To about 15cm 2 , about 10cm 2 To about 20cm 2 , about 10cm 2 To about 25cm 2 , about 10cm 2 About 30cm 2 , about 10cm 2 To about 35cm 2 , about 10cm 2 To about 40cm2 , about 10cm 2 To about 45cm 2 , about 10cm 2 To about 50cm 2 、Approx. 15cm 2 To about 20cm 2 、Approx. 15cm 2 To about 25cm 2 、Approx. 15cm 2 About 30cm 2 、Approx. 15cm 2 To about 35cm 2 、Approx. 15cm 2 To about 40cm 2 、Approx. 15cm 2 To about 45cm 2 、Approx. 15cm 2 To about 50cm 2 、About 20cm 2 To about 25cm 2 、About 20cm 2 About 30cm 2 、About 20cm 2 To about 35cm 2 、About 20cm 2 To about 40cm 2 、About 20cm 2 To about 45cm 2 、About 20cm 2 To about 50cm 2 、Approx. 25cm 2 About 30cm 2 、Approx. 25cm 2 To about 35cm 2 、Approx. 25cm 2 To about 40cm 2 、Approx. 25cm 2 To about 45cm 2 、Approx. 25cm 2 To about 50cm 2 、About 30cm 2 To about 35cm 2 、About 30cm 2 To about 40cm 2 、About 30cm 2 To about 45cm 2 or about 30cm 2 To about 50cm 2 .

[0166] In certain embodiments, the disclosed method for treating self-closing disease can include a single treatment course or multiple treatment courses. In various aspects of these embodiments, the disclosed method for treating self-closing disease includes, for example, about 1 to about 5 treatment courses, about 1 to about 10 treatment courses, about 1 to about 15 treatment courses, about 1 to about 20 treatment courses, about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses or about 15 to about 20 treatment courses. In other aspects of these embodiments, the disclosed method for treating self-closing disease can include multiple treatment courses that last for months or years.

[0167] In some embodiments, the disclosed methods of treating autism include exposing a region of the head to infrared light for, e.g., about 5 minutes to about 10 minutes, about 5 minutes to about 15 minutes, about 5 minutes to about 20 minutes, about 5 minutes to about 25 minutes, about 5 minutes to about 30 minutes, about 5 minutes to about 35 minutes, about 5 minutes to about 40 minutes, about 10 minutes to about 15 minutes, about 10 minutes to about 20 minutes, about 10 minutes to about 25 minutes, about 10 minutes to about 30 minutes, about 10 minutes to about 35 minutes, about 10 minutes to about 40 minutes, about 15 minutes to about 20 minutes, about 15 minutes to about 25 minutes, about 15 minutes to about 30 minutes, about 15 minutes to about 35 minutes, or about 15 minutes to about 40 minutes, during the treatment process.

[0168] In some embodiments, the disclosed method of treating autism includes infrared light having an average irradiance range of, for example, about 50 mW / cm 2 About 100mW / cm 2 , about 50mW / cm 2 to about 150mW / cm 2 , about 50mW / cm 2 About 200mW / cm 2 , about 50mW / cm 2 to about 250mW / cm 2 , about 50mW / cm 2 About 300mW / cm 2 , about 100mW / cm 2 to about 150mW / cm 2 , about 100mW / cm 2 About 200mW / cm 2 , about 100mW / cm 2 to about 250mW / cm 2, about 100mW / cm 2 To about 300mW / cm 2 , about 150mW / cm 2 About 200mW / cm 2 , about 150mW / cm 2 to about 250mW / cm 2 , about 150mW / cm 2 To about 300mW / cm 2 , about 200mW / cm 2 to about 250mW / cm 2 , about 200mW / cm 2 To about 300mW / cm 2 or about 250mW / cm 2 To about 300mW / cm 2 .

[0169] In some embodiments, the disclosed method of treating autism includes infrared light including an average light flux of, for example, about 30 J / cm2 over a body area. 2 To about 50J / cm 2 , about 30J / cm 2 To about 75J / cm 2 , about 30J / cm 2 To about 100 J / cm 2 , about 30J / cm 2 To about 125J / cm 2 , about 30J / cm 2 About 150 J / cm 2 , about 50J / cm 2 To about 75J / cm 2 , about 50J / cm 2 To about 100 J / cm 2 , about 50J / cm 2 To about 125J / cm 2 , about 50J / cm 2 About 150 J / cm 2 , about 75J / cm 2 To about 100 J / cm 2 , about 75J / cm 2 To about 125J / cm 2 , about 75J / cm 2 About 150 J / cm 2 , about 100J / cm 2 To about 125J / cm 2 , about 100J / cm 2 About 150 J / cm 2or about 100 J / cm 2 About 150 J / cm 2 .

[0170] In some embodiments, the disclosed method of treating autism includes infrared light including a total energy incident during the treatment process of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about 2.5 kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, about From about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0171] In some embodiments, the disclosed method of treating autism includes infrared light including a total power of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW, about 1,000 mW to about 9,000 mW, about 2,000 mW to about 3,000 mW, about 2,000 mW to about 4,000 mW, about 2,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about 5, The present invention relates to a power supply having a power of about 1000 mW, about 3,000 mW to about 6,000 mW, about 3,000 mW to about 7,000 mW, about 3,000 mW to about 8,000 mW, about 3,000 mW to about 9,000 mW, about 4,000 mW to about 5,000 mW, about 4,000 mW to about 6,000 mW, about 4,000 mW to about 7,000 mW, about 4,000 mW to about 8,000 mW, about 4,000 mW to about 9,000 mW, about 5,000 mW to about mW to about 6,000 mW, about 5,000 mW to about 7,000 mW, about 5,000 mW to about 8,000 mW, about 5,000 mW to about 9,000 mW, about 6,000 mW to about 7,000 mW, about 6,000 mW to about 8,000 mW, about 6,000 mW to about 9,000 mW, about 7,000 mW to about 8,000 mW, about 7,000 mW to about 9,000 mW, or about 8,000 mW to about 9,000 mW.

[0172] In various aspects of these embodiments, the disclosed method of treating autism comprises exposing a 2 To about 27cm 2 In other aspects of these embodiments, the disclosed method for treating autism includes infrared light including the following items: about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2, the total energy incident during the treatment process is about 0.5kJ to about 6kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating autism includes infrared light having a total power of about 900mW to about 8,100mW on the head area. In other aspects of these embodiments, the disclosed method for treating autism also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be applied using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating autism can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0173] In various aspects of these embodiments, the disclosed method of treating autism comprises exposing a 2 To about 28cm 2 In other aspects of these embodiments, the disclosed method for treating autism includes infrared light including the following items: about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , the total energy incident during the treatment process is about 1.5kJ to about 3.5kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating autism includes infrared light having a total power of about 1,000mW to about 8,400mW on the head area. In other aspects of these embodiments, the disclosed method for treating autism also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be applied using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating autism can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0174] In various aspects of these embodiments, the disclosed method of treating autism comprises exposing a 2 To about 26cm 2 In other aspects of these embodiments, the disclosed method for treating autism includes infrared light including the following items: about 250 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 150 J / cm 2 To about 200J / cm 2 , the total energy incident during the treatment process is about 4kJ to about 5kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating autism includes infrared light having a total power of about 3,000mW to about 8,400mW on the head area. In other aspects of these embodiments, the disclosed method for treating autism also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be applied using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating autism can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0175] The present specification discloses a method of treating attention deficit hyperactivity disorder in an individual using photobiomodulation therapy, the method comprising exposing a head region to infrared light of a photobiomodulation therapy garment disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include a forehead region, a temporal region, an occipital region, or any combination thereof.

[0176] In some embodiments, the disclosed methods of treating attention deficit hyperactivity disorder include exposing a head region including, for example, an area of ​​about 10 cm 2 To about 15cm 2 , about 10cm 2 To about 20cm 2 , about 10cm 2 To about 25cm 2 , about 10cm 2 About 30cm 2 , about 10cm 2 To about 35cm 2 , about 10cm 2To about 40cm 2 , about 10cm 2 To about 45cm 2 , about 10cm 2 To about 50cm 2 、Approx. 15cm 2 To about 20cm 2 、Approx. 15cm 2 To about 25cm 2 、Approx. 15cm 2 About 30cm 2 、Approx. 15cm 2 To about 35cm 2 、Approx. 15cm 2 To about 40cm 2 、Approx. 15cm 2 To about 45cm 2 、Approx. 15cm 2 To about 50cm 2 、About 20cm 2 To about 25cm 2 、About 20cm 2 About 30cm 2 、About 20cm 2 To about 35cm 2 、About 20cm 2 To about 40cm 2 、About 20cm 2 To about 45cm 2 、About 20cm 2 To about 50cm 2 、Approx. 25cm 2 About 30cm 2 、Approx. 25cm 2 To about 35cm 2 、Approx. 25cm 2 To about 40cm 2 、Approx. 25cm 2 To about 45cm 2 、Approx. 25cm 2 To about 50cm 2 、About 30cm 2 To about 35cm 2 、About 30cm 2 To about 40cm 2 、About 30cm 2 To about 45cm 2 or about 30cm 2 To about 50cm 2 .

[0177] In some embodiments, the disclosed methods for treating attention deficit hyperactivity disorder may include a single treatment course or multiple treatment courses. In various aspects of these embodiments, the disclosed methods for treating attention deficit hyperactivity disorder include, for example, about 1 to about 5 treatment courses, about 1 to about 10 treatment courses, about 1 to about 15 treatment courses, about 1 to about 20 treatment courses, about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses. In other aspects of these embodiments, the disclosed methods for treating attention deficit hyperactivity disorder may include multiple treatment courses that last for months or years.

[0178] In some embodiments, the disclosed methods of treating attention deficit hyperactivity disorder include exposing a region of the head to infrared light for, e.g., about 5 minutes to about 10 minutes, about 5 minutes to about 15 minutes, about 5 minutes to about 20 minutes, about 5 minutes to about 25 minutes, about 5 minutes to about 30 minutes, about 5 minutes to about 35 minutes, about 5 minutes to about 40 minutes, about 10 minutes to about 15 minutes, about 10 minutes to about 20 minutes, about 10 minutes to about 25 minutes, about 10 minutes to about 30 minutes, about 10 minutes to about 35 minutes, about 10 minutes to about 40 minutes, about 15 minutes to about 20 minutes, about 15 minutes to about 25 minutes, about 15 minutes to about 30 minutes, about 15 minutes to about 35 minutes, or about 15 minutes to about 40 minutes, during the course of treatment.

[0179] In some embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes infrared light having an average irradiance range of, for example, about 50 mW / cm 2 About 100mW / cm 2 , about 50mW / cm 2 to about 150mW / cm 2 , about 50mW / cm 2 About 200mW / cm 2 , about 50mW / cm 2 to about 250mW / cm 2 , about 50mW / cm 2 About 300mW / cm 2 , about 100mW / cm 2 to about 150mW / cm 2 , about 100mW / cm 2 About 200mW / cm 2 , about 100mW / cm2 to about 250mW / cm 2 , about 100mW / cm 2 To about 300mW / cm 2 , about 150mW / cm 2 About 200mW / cm 2 , about 150mW / cm 2 to about 250mW / cm 2 , about 150mW / cm 2 To about 300mW / cm 2 , about 200mW / cm 2 to about 250mW / cm 2 , about 200mW / cm 2 To about 300mW / cm 2 or about 250mW / cm 2 To about 300mW / cm 2 .

[0180] In some embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes infrared light including an average light flux of, for example, about 30 J / cm 2 To about 50J / cm 2 , about 30J / cm 2 To about 75J / cm 2 , about 30J / cm 2 To about 100 J / cm 2 , about 30J / cm 2 To about 125J / cm 2 , about 30J / cm 2 About 150 J / cm 2 , about 50J / cm 2 To about 75J / cm 2 , about 50J / cm 2 To about 100 J / cm 2 , about 50J / cm 2 To about 125J / cm 2 , about 50J / cm 2 About 150 J / cm 2 , about 75J / cm 2 To about 100 J / cm 2 , about 75J / cm 2 To about 125J / cm 2 , about 75J / cm 2 About 150 J / cm 2 , about 100J / cm 2 To about 125J / cm 2, about 100J / cm 2 About 150 J / cm 2 or about 100 J / cm 2 About 150 J / cm 2 .

[0181] In some embodiments, the disclosed methods of treating attention deficit hyperactivity disorder include infrared light including a total energy incident during the treatment process of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1 .0 kJ to about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, From about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0182] In some embodiments, the disclosed methods of treating attention deficit hyperactivity disorder include infrared light including a total power of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW, about 1,000 mW to about 9,000 mW, about 1,000 mW to about 10,000 mW, about 1,000 mW to about 11,000 mW, about 1,000 mW to about 12,000 mW, about 1,000 mW to about 13,000 mW, about 1,000 mW to about 14,000 mW, about 1,000 mW to about 15,000 mW, about 1,000 mW to about 16,000 mW, about 1,000 mW to about 17,000 mW, about 1,000 mW to about 18,000 mW, about 1 The power consumption of the present invention is 2,000 mW, about 1,000 mW to about 9,000 mW, about 2,000 mW to about 3,000 mW, about 2,000 mW to about 4,000 mW, about 2,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about about 5,000 mW, about 3,000 mW to about 6,000 mW, about 3,000 mW to about 7,000 mW, about 3,000 mW to about 8,000 mW, about 3,000 mW to about 9,000 mW, about 4,000 mW to about 5,000 mW, about 4,000 mW to about 6,000 mW, about 4,000 mW to about 7,000 mW, about 4,000 mW to about 8,000 mW, about 4,000 mW to about 9,000 mW, about 5,000 mW to about The power supply may be selected from the group consisting of: a) about 1,000 mW to about 6,000 mW, b) about 5,000 mW to about 7,000 mW, c) about 5,000 mW to about 8,000 mW, d) about 5,000 mW to about 9,000 mW, d) about 6,000 mW to about 7,000 mW, d) about 6,000 mW to about 8,000 mW, d) about 6,000 mW to about 9,000 mW, d) about 7,000 mW to about 8,000 mW, d) about 7,000 mW to about 9,000 mW, or d) about 8,000 mW to about 9,000 mW.

[0183] In various aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder comprises exposing a 2 To about 27cm 2 In other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes infrared light including the following items: about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2, the total energy incident during the treatment process is about 0.5 kJ to about 6 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating attention deficit hyperactivity disorder includes infrared light having a total power of about 900 mW to about 8,100 mW on the head area. In other aspects of these embodiments, the disclosed method for treating attention deficit hyperactivity disorder also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating attention deficit hyperactivity disorder can comprise a single treatment course or multiple treatment courses, such as about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0184] In various aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder comprises exposing a 2 To about 28cm 2 In other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes infrared light including the following items: about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2, the total energy incident during the treatment process is about 1.5 kJ to about 3.5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating attention deficit hyperactivity disorder includes infrared light having a total power of about 1,000 mW to about 8,400 mW on the head area. In other aspects of these embodiments, the disclosed method for treating attention deficit hyperactivity disorder also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating attention deficit hyperactivity disorder can comprise a single treatment course or multiple treatment courses, such as about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0185] In various aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder comprises exposing a 2 To about 26cm 2 In other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes infrared light including the following items: about 250 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 150 J / cm 2 About 200 J / cm 2, the total energy incident during the treatment process is about 4kJ to about 5kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating attention deficit hyperactivity disorder includes infrared light having a total power of about 3,000mW to about 8,400mW on the head area. In other aspects of these embodiments, the disclosed method for treating attention deficit hyperactivity disorder also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be applied using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating attention deficit hyperactivity disorder can comprise a single treatment course or multiple treatment courses, such as about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0186] The present specification discloses a method of treating a neurodevelopmental disorder in an individual using photobiomodulation therapy, the method comprising exposing a head region to infrared light of a photobiomodulation therapy garment disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include a forehead region, a temporal region, an occipital region, or any combination thereof.

[0187] In some embodiments, the disclosed methods of treating a neurodevelopmental disorder include exposing a head region including, for example, an area of ​​about 10 cm 2 To about 15cm 2 , about 10cm 2 To about 20cm 2 , about 10cm 2 To about 25cm 2 , about 10cm 2 About 30cm 2 , about 10cm 2 To about 35cm 2 , about 10cm 2 To about 40cm 2 , about 10cm 2 To about 45cm 2 , about 10cm 2 To about 50cm 2 、Approx. 15cm 2 To about 20cm 2 、Approx. 15cm 2 To about 25cm 2 、Approx. 15cm 2 About 30cm 2 、Approx. 15cm2 To about 35cm 2 、Approx. 15cm 2 To about 40cm 2 、Approx. 15cm 2 To about 45cm 2 、Approx. 15cm 2 To about 50cm 2 、About 20cm 2 To about 25cm 2 、About 20cm 2 About 30cm 2 、About 20cm 2 To about 35cm 2 、About 20cm 2 To about 40cm 2 、About 20cm 2 To about 45cm 2 、About 20cm 2 To about 50cm 2 、Approx. 25cm 2 About 30cm 2 、Approx. 25cm 2 To about 35cm 2 、Approx. 25cm 2 To about 40cm 2 、Approx. 25cm 2 To about 45cm 2 、Approx. 25cm 2 To about 50cm 2 、About 30cm 2 To about 35cm 2 、About 30cm 2 To about 40cm 2 、About 30cm 2 To about 45cm 2 or about 30cm 2 To about 50cm 2 .

[0188] In some embodiments, the disclosed method for treating neurodevelopmental disorders may include a single treatment course or multiple treatment courses. In various aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders includes, for example, about 1 to about 5 treatment courses, about 1 to about 10 treatment courses, about 1 to about 15 treatment courses, about 1 to about 20 treatment courses, about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses. In other aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders may include multiple treatment courses that last for months or years.

[0189] In some embodiments, the disclosed methods of treating a neurodevelopmental disorder comprise exposing a region of the head to infrared light for, e.g., about 5 minutes to about 10 minutes, about 5 minutes to about 15 minutes, about 5 minutes to about 20 minutes, about 5 minutes to about 25 minutes, about 5 minutes to about 30 minutes, about 5 minutes to about 35 minutes, about 5 minutes to about 40 minutes, about 10 minutes to about 15 minutes, about 10 minutes to about 20 minutes, about 10 minutes to about 25 minutes, about 10 minutes to about 30 minutes, about 10 minutes to about 35 minutes, about 10 minutes to about 40 minutes, about 15 minutes to about 20 minutes, about 15 minutes to about 25 minutes, about 15 minutes to about 30 minutes, about 15 minutes to about 35 minutes, or about 15 minutes to about 40 minutes, during the course of treatment.

[0190] In some embodiments, the disclosed methods of treating a neurodevelopmental disorder include infrared light having an average irradiance range of, for example, about 50 mW / cm 2 About 100mW / cm 2 , about 50mW / cm 2 to about 150mW / cm 2 , about 50mW / cm 2 About 200mW / cm 2 , about 50mW / cm 2 to about 250mW / cm 2 , about 50mW / cm 2 About 300mW / cm 2 , about 100mW / cm 2 to about 150mW / cm 2 , about 100mW / cm 2 About 200mW / cm 2 , about 100mW / cm 2to about 250mW / cm 2 , about 100mW / cm 2 About 300mW / cm 2 , about 150mW / cm 2 About 200mW / cm 2 , about 150mW / cm 2 to about 250mW / cm 2 , about 150mW / cm 2 About 300mW / cm 2 , about 200mW / cm 2 to about 250mW / cm 2 , about 200mW / cm 2 About 300mW / cm 2 or about 250mW / cm 2 About 300mW / cm 2 .

[0191] In some embodiments, the disclosed methods of treating a neurodevelopmental disorder include infrared light having an average light flux of, for example, about 30 J / cm 2 To about 50J / cm 2 , about 30J / cm 2 About 75J / cm 2 , about 30J / cm 2 To about 100 J / cm 2 , about 30J / cm 2 To about 125J / cm 2 , about 30J / cm 2 About 150 J / cm 2 , about 50J / cm 2 About 75J / cm 2 , about 50J / cm 2 To about 100 J / cm 2 , about 50J / cm 2 To about 125J / cm 2 , about 50J / cm 2 About 150 J / cm 2 , about 75J / cm 2 To about 100 J / cm 2 , about 75J / cm 2 To about 125J / cm 2 , about 75J / cm 2 About 150 J / cm 2 , about 100J / cm 2 To about 125J / cm 2 , about 100J / cm 2About 150 J / cm 2 or about 100 J / cm 2 About 150 J / cm 2 .

[0192] In some embodiments, the disclosed methods of treating a neurodevelopmental disorder include infrared light including a total energy incident during the treatment process of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5 kJ to about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about 2. kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, about From about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0193] In some embodiments, the disclosed methods of treating a neurodevelopmental disorder include infrared light including a total power of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW, about 1,000 mW to about 9,000 mW, about 1,000 mW to about 10,000 mW, about 1,000 mW to about 11,000 mW, about 1,000 mW to about 12,000 mW, about 1,000 mW to about 13,000 mW, about 1,000 mW to about 14,000 mW, about 1,000 mW to about 15,000 mW, about 1,000 mW to about 16,000 mW, about 1,000 mW to about 17,000 mW, about 1,000 mW to about 18,000 mW, about 1 mW, about 1,000 mW to about 9,000 mW, about 2,000 mW to about 3,000 mW, about 2,000 mW to about 4,000 mW, about 2,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about 5,000 mW, about 3,000 mW to about 6,000 mW, about 3,000 mW to about 7,000 mW, about 3,000 mW to about 8,000 mW, about 3,000 mW to about 9,000 mW, about 4,000 mW to about 5,000 mW, about 4,000 mW to about 6,000 mW, about 4,000 mW to about 7,000 mW, about 4,000 mW to about 8,000 mW, about 4,000 mW to about 9,000 mW, about 5,000 mW to about The power supply voltage may be selected from the group consisting of: 1,000 mW to about 6,000 mW, 1,000 mW to about 7,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, or 1,000 mW to about 9,000 mW.

[0194] In various aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder comprises exposing a 2 To about 27cm 2 In other aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder comprises infrared light comprising the following items: about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2, the total energy incident during the treatment process is about 0.5 kJ to about 6 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders includes infrared light having a total power of about 900 mW to about 8,100 mW on the head area. In other aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating a neurodevelopmental disorder can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0195] In various aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder comprises exposing a 2 To about 28cm 2 In other aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder comprises infrared light comprising the following items: about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , the total energy incident during the treatment process is about 1.5 kJ to about 3.5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders includes infrared light having a total power of about 1,000 mW to about 8,400 mW on the head area. In other aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating a neurodevelopmental disorder can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0196] In various aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder comprises exposing a 2 To about 26cm 2 In other aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder comprises infrared light comprising the following items: about 250 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 150 J / cm 2 About 200 J / cm 2 , the total energy incident during the treatment process is about 4kJ to about 5kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders includes infrared light having a total power of about 3,000mW to about 8,400mW on the head area. In other aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating a neurodevelopmental disorder can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0197] The present specification discloses a method of treating a neurocognitive degenerative disorder in an individual using photobiomodulation therapy, the method comprising exposing a head region to infrared light of a photobiomodulation therapy garment disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include a forehead region, a temporal region, an occipital region, or any combination thereof.

[0198] In some embodiments, the disclosed methods of treating a neurocognitive degenerative disorder include exposing a head region including, for example, an area of ​​about 10 cm 2 To about 15cm 2 , about 10cm 2 To about 20cm 2 , about 10cm 2 To about 25cm 2 , about 10cm 2 About 30cm 2 , about 10cm 2 To about 35cm2 , about 10cm 2 To about 40cm 2 , about 10cm 2 To about 45cm 2 , about 10cm 2 To about 50cm 2 、Approx. 15cm 2 To about 20cm 2 、Approx. 15cm 2 To about 25cm 2 、Approx. 15cm 2 About 30cm 2 、Approx. 15cm 2 To about 35cm 2 、Approx. 15cm 2 To about 40cm 2 、Approx. 15cm 2 To about 45cm 2 、Approx. 15cm 2 To about 50cm 2 、About 20cm 2 To about 25cm 2 、About 20cm 2 About 30cm 2 、About 20cm 2 To about 35cm 2 、About 20cm 2 To about 40cm 2 、About 20cm 2 To about 45cm 2 、About 20cm 2 To about 50cm 2 、Approx. 25cm 2 About 30cm 2 、Approx. 25cm 2 To about 35cm 2 、Approx. 25cm 2 To about 40cm 2 、Approx. 25cm 2 To about 45cm 2 、Approx. 25cm 2 To about 50cm 2 、About 30cm 2 To about 35cm 2 、About 30cm 2 To about 40cm 2 、About 30cm 2 To about 45cm 2 or about 30cm 2 To about 50cm 2 .

[0199] In some embodiments, the disclosed method for treating neurocognitive degeneration disorder may include a single treatment course or multiple treatment courses. In various aspects of these embodiments, the disclosed method for treating neurocognitive degeneration disorder includes, for example, about 1 to about 5 treatment courses, about 1 to about 10 treatment courses, about 1 to about 15 treatment courses, about 1 to about 20 treatment courses, about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses or about 15 to about 20 treatment courses. In other aspects of these embodiments, the disclosed method for treating neurocognitive degeneration disorder may include multiple treatment courses that last for months or years.

[0200] In some embodiments, the disclosed method of treating a neurocognitive degenerative disorder comprises exposing a region of the head to infrared light for, e.g., about 5 minutes to about 10 minutes, about 5 minutes to about 15 minutes, about 5 minutes to about 20 minutes, about 5 minutes to about 25 minutes, about 5 minutes to about 30 minutes, about 5 minutes to about 35 minutes, about 5 minutes to about 40 minutes, about 10 minutes to about 15 minutes, about 10 minutes to about 20 minutes, about 10 minutes to about 25 minutes, about 10 minutes to about 30 minutes, about 10 minutes to about 35 minutes, about 10 minutes to about 40 minutes, about 15 minutes to about 20 minutes, about 15 minutes to about 25 minutes, about 15 minutes to about 30 minutes, about 15 minutes to about 35 minutes, or about 15 minutes to about 40 minutes, during the course of treatment.

[0201] In some embodiments, the disclosed methods of treating neurocognitive degenerative disorders include infrared light having an average irradiance range of, for example, about 50 mW / cm 2 About 100mW / cm 2 , about 50mW / cm 2 to about 150mW / cm 2 , about 50mW / cm 2 About 200mW / cm 2 , about 50mW / cm 2 to about 250mW / cm 2 , about 50mW / cm 2 To about 300mW / cm 2 , about 100mW / cm 2 to about 150mW / cm 2 , about 100mW / cm 2 About 200mW / cm 2 , about 100mW / cm2 to about 250mW / cm 2 , about 100mW / cm 2 To about 300mW / cm 2 , about 150mW / cm 2 About 200mW / cm 2 , about 150mW / cm 2 to about 250mW / cm 2 , about 150mW / cm 2 To about 300mW / cm 2 , about 200mW / cm 2 to about 250mW / cm 2 , about 200mW / cm 2 To about 300mW / cm 2 or about 250mW / cm 2 To about 300mW / cm 2 .

[0202] In some embodiments, the disclosed methods of treating neurocognitive degenerative disorders include infrared light having an average light flux of, for example, about 30 J / cm2 over a body region. 2 To about 50J / cm 2 , about 30J / cm 2 To about 75J / cm 2 , about 30J / cm 2 To about 100 J / cm 2 , about 30J / cm 2 To about 125J / cm 2 , about 30J / cm 2 About 150 J / cm 2 , about 50J / cm 2 To about 75J / cm 2 , about 50J / cm 2 To about 100 J / cm 2 , about 50J / cm 2 To about 125J / cm 2 , about 50J / cm 2 About 150 J / cm 2 , about 75J / cm 2 To about 100 J / cm 2 , about 75J / cm 2 To about 125J / cm 2 , about 75J / cm 2 About 150 J / cm 2 , about 100J / cm 2 To about 125J / cm 2, about 100J / cm 2 About 150 J / cm 2 or about 100 J / cm 2 About 150 J / cm 2 .

[0203] In some embodiments, the disclosed methods of treating neurocognitive degenerative disorders include infrared light including a total energy incident during the treatment process of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.5 kJ 0 kJ to about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about 2 kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, From about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0204] In some embodiments, the disclosed methods of treating neurocognitive degenerative disorders include infrared light including a total power of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW, about 1,000 mW to about 9,000 mW, about 1,000 mW to about 10,000 mW, about 1,000 mW to about 11,000 mW, about 1,000 mW to about 12,000 mW, about 1,000 mW to about 13,000 mW, about 1,000 mW to about 14,000 mW, about 1,000 mW to about 15,000 mW, about 1,000 mW to about 16,000 mW, about 1,000 mW to about 17,000 mW, about 1,000 mW to about 18,000 mW, about 1 0mW, about 1,000mW to about 9,000mW, about 2,000mW to about 3,000mW, about 2,000mW to about 4,000mW, about 2,000mW to about 5,000mW, about 2,000mW to about 6,000mW, about 2,000mW to about 7,000mW, about 2,000mW to about 8,000mW, about 2,000mW to about 9,000mW, about 3,000mW to about 4,000mW, about 3,000mW to about about 5,000 mW, about 3,000 mW to about 6,000 mW, about 3,000 mW to about 7,000 mW, about 3,000 mW to about 8,000 mW, about 3,000 mW to about 9,000 mW, about 4,000 mW to about 5,000 mW, about 4,000 mW to about 6,000 mW, about 4,000 mW to about 7,000 mW, about 4,000 mW to about 8,000 mW, about 4,000 mW to about 9,000 mW, about 5,000 mW to about The power supply may be selected from the group consisting of: a) about 1,000 mW to about 6,000 mW, b) about 5,000 mW to about 7,000 mW, c) about 5,000 mW to about 8,000 mW, d) about 5,000 mW to about 9,000 mW, d) about 6,000 mW to about 7,000 mW, d) about 6,000 mW to about 8,000 mW, d) about 6,000 mW to about 9,000 mW, d) about 7,000 mW to about 8,000 mW, d) about 7,000 mW to about 9,000 mW, or d) about 8,000 mW to about 9,000 mW.

[0205] In various aspects of these embodiments, the disclosed method of treating a neurocognitive degenerative disorder comprises exposing a 2 To about 27cm 2 In other aspects of these embodiments, the disclosed method of treating a neurocognitive degenerative disorder comprises infrared light comprising the following items: about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2, the total energy incident during the treatment process is about 0.5kJ to about 6kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating neurocognitive degenerative disorders includes infrared light having a total power of about 900mW to about 8,100mW on the head area. In other aspects of these embodiments, the disclosed method for treating neurocognitive degenerative disorders also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating neurocognitive degenerative disorders can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0206] In various aspects of these embodiments, the disclosed method of treating a neurocognitive degenerative disorder comprises exposing a 2 To about 28cm 2 In other aspects of these embodiments, the disclosed method of treating a neurocognitive degenerative disorder comprises infrared light comprising the following items: about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2, the total energy incident during the treatment process is about 1.5 kJ to about 3.5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating neurocognitive degenerative disorders includes infrared light having a total power of about 1,000 mW to about 8,400 mW on the head area. In other aspects of these embodiments, the disclosed method for treating neurocognitive degenerative disorders also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating neurocognitive degenerative disorders can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0207] In various aspects of these embodiments, the disclosed method of treating a neurocognitive degenerative disorder comprises exposing a 2 To about 26cm 2 In other aspects of these embodiments, the disclosed method of treating a neurocognitive degenerative disorder comprises infrared light comprising the following items: about 250 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 150 J / cm 2 About 200 J / cm 2, the total energy incident during the treatment process is about 4kJ to about 5kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for treating neurocognitive degenerative disorders includes infrared light having a total power of about 3,000mW to about 8,400mW on the head area. In other aspects of these embodiments, the disclosed method for treating neurocognitive degenerative disorders also includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods of treating neurocognitive degenerative disorders can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0208] Photobiomodulation therapy using photobiomodulation therapy clothing disclosed herein can also be applied to the trunk or its region, or limbs (such as one or two arms) or its region, or one or two legs or its region. This non-invasive light-based neuromodulation therapy does not require drugs, and by providing various active photochemical reactions, changes the working mode of the user's nervous system from the neuron level upward, thereby providing long-term benefits. For example, photobiomodulation therapy can increase the generation of neuronal mitochondrial energy and adenosine triphosphate (ATP) by enhancing the production of increased cellular energy by enhancing cytochrome c oxidase activity. In addition, the transfer of light energy can also trigger the generation of reactive oxygen species (ROS) (which can regulate inflammation at the cell and tissue level and improve cell repair and healing) and the generation of nitric oxide (NO) (which is essential for good vascular health and optimal blood flow, nutrient delivery and waste removal). This is important because it is harmful for the body area to receive insufficient blood flow and circulation, and may cause slow wound healing time, ischemia and / or necrosis. Increased cellular energy and increased blood flow lead to increased neurogenesis and neuronal plasticity, improved neuroprotection, enhanced neural repair and reduced inflammation.

[0209] The present specification discloses a method for improving vascular hemodynamics of an individual using photobiomodulation therapy, the method comprising exposing a body region to infrared light of a photobiomodulation therapy garment disclosed herein for one or more treatment processes. In various aspects of these embodiments, the disclosed method for improving vascular hemodynamics comprises exposing a body region comprising a torso region, an arm region, a leg region, or any combination thereof. Non-limiting examples of torso regions include an abdominal region, a back region, a shoulder region, or any combination thereof. Non-limiting examples of arm regions include an upper arm region, a forearm region, or a hand. Non-limiting examples of leg regions include a thigh region, a calf region, or a foot.

[0210] In some embodiments, the disclosed method of improving vascular hemodynamics comprises exposing a head region comprising, for example, an area of ​​about 10 cm 2 To about 25cm 2 , about 10cm 2 To about 50cm 2 , about 10cm 2 To about 75cm 2 , about 10cm 2 To about 100cm 2 , about 10cm 2 About 125cm 2 , about 10cm 2 About 150cm 2 , about 10cm 2 About 175cm 2 , about 10cm 2 To about 200cm 2 , about 10cm 2 To about 225cm 2 , about 10cm 2 To about 250cm 2 , about 10cm 2 To about 275cm 2 , about 10cm 2 To about 300cm 2 、Approx. 25cm 2 To about 50cm 2 、Approx. 25cm 2 To about 75cm 2 、Approx. 25cm 2 To about 100cm 2 、Approx. 25cm 2 About 125cm 2 、Approx. 25cm 2 About 150cm 2 、Approx. 25cm 2 About 175cm 2 、Approx. 25cm2 To about 200cm 2 、Approx. 25cm 2 To about 225cm 2 、Approx. 25cm 2 To about 250cm 2 、Approx. 25cm 2 To about 275cm 2 、Approx. 25cm 2 To about 300cm 2 、About 50cm 2 To about 75cm 2 、About 50cm 2 To about 100cm 2 、About 50cm 2 About 125cm 2 、About 50cm 2 About 150cm 2 、About 50cm 2 About 175cm 2 、About 50cm 2 To about 200cm 2 、About 50cm 2 To about 225cm 2 、About 50cm 2 To about 250cm 2 、About 50cm 2 To about 275cm 2 、About 50cm 2 To about 300cm 2 、Approx. 75cm 2 To about 100cm 2 、Approx. 75cm 2 About 125cm 2 、Approx. 75cm 2 About 150cm 2 、Approx. 75cm 2 About 175cm 2 、Approx. 75cm 2 To about 200cm 2 、Approx. 75cm 2 To about 225cm 2 、Approx. 75cm 2 To about 250cm 2 、Approx. 75cm 2 To about 275cm 2 、Approx. 75cm 2 To about 300cm 2 , about 100cm 2 About 125cm 2 , about 100cm 2 About 150cm2 , about 100cm 2 About 175cm 2 , about 100cm 2 To about 200cm 2 , about 100cm 2 To about 225cm 2 , about 100cm 2 To about 250cm 2 , about 100cm 2 To about 275cm 2 or about 100cm 2 To about 300cm 2 .

[0211] In some embodiments, the disclosed methods of improving vascular hemodynamics may include a single treatment course or multiple treatment courses. In various aspects of these embodiments, the disclosed methods of improving vascular hemodynamics include, for example, about 1 to about 5 treatment courses, about 1 to about 10 treatment courses, about 1 to about 15 treatment courses, about 1 to about 20 treatment courses, about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses. In other aspects of these embodiments, the disclosed methods of improving vascular hemodynamics may include multiple treatment courses that last for months or years.

[0212] In some embodiments, the disclosed method of improving vascular hemodynamics comprises exposing a head region to infrared light during a treatment course, for example, from about 5 minutes to about 10 minutes, from about 5 minutes to about 15 minutes, from about 5 minutes to about 20 minutes, from about 5 minutes to about 25 minutes, from about 5 minutes to about 30 minutes, from about 5 minutes to about 35 minutes, from about 5 minutes to about 40 minutes, from about 10 minutes to about 15 minutes, from about 10 minutes to about 20 minutes, from about 10 minutes to about 25 minutes, from about 10 minutes to about 30 minutes, from about 10 minutes to about 35 minutes, from about 10 minutes to about 40 minutes, from about 15 minutes to about 20 minutes, from about 15 minutes to about 25 minutes, from about 15 minutes to about 30 minutes, from about 15 minutes to about 35 minutes, or from about 15 minutes to about 40 minutes.

[0213] In some embodiments, the disclosed method of improving vascular hemodynamics includes infrared light having an average irradiance range of, for example, about 50 mW / cm 2 About 100mW / cm 2 , about 50mW / cm2 to about 150mW / cm 2 , about 50mW / cm 2 About 200mW / cm 2 , about 50mW / cm 2 to about 250mW / cm 2 , about 50mW / cm 2 About 300mW / cm 2 , about 100mW / cm 2 to about 150mW / cm 2 , about 100mW / cm 2 About 200mW / cm 2 , about 100mW / cm 2 to about 250mW / cm 2 , about 100mW / cm 2 About 300mW / cm 2 , about 150mW / cm 2 About 200mW / cm 2 , about 150mW / cm 2 to about 250mW / cm 2 , about 150mW / cm 2 About 300mW / cm 2 , about 200mW / cm 2 to about 250mW / cm 2 , about 200mW / cm 2 About 300mW / cm 2 or about 250mW / cm 2 About 300mW / cm 2 .

[0214] In some embodiments, the disclosed method of improving vascular hemodynamics includes infrared light including an average light flux of, for example, about 30 J / cm 2 To about 50J / cm 2 , about 30J / cm 2 About 75J / cm 2 , about 30J / cm 2 To about 100 J / cm 2 , about 30J / cm 2 To about 125J / cm 2 , about 30J / cm 2 About 150 J / cm 2 , about 50J / cm 2 About 75J / cm 2 , about 50J / cm 2 To about 100 J / cm2 , about 50J / cm 2 To about 125J / cm 2 , about 50J / cm 2 About 150 J / cm 2 , about 75J / cm 2 To about 100 J / cm 2 , about 75J / cm 2 To about 125J / cm 2 , about 75J / cm 2 About 150 J / cm 2 , about 100J / cm 2 To about 125J / cm 2 , about 100J / cm 2 About 150 J / cm 2 or about 100 J / cm 2 About 150 J / cm 2 .

[0215] In some embodiments, the disclosed method of improving vascular hemodynamics comprises infrared light comprising a total energy incident during the treatment process of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about kJ to about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about 2 kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, From about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0216] In some embodiments, the disclosed method of improving vascular hemodynamics comprises infrared light comprising a total power of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW, about 1,000 mW to about 9,000 mW, about 1,000 mW to about 10,000 mW, about 1,000 mW to about 11,000 mW, about 1,000 mW to about 12,000 mW, about 1,000 mW to about 13,000 mW, about 1,000 mW to about 14,000 mW, about 1,000 mW to about 15,000 mW, about 1,000 mW to about 16,000 mW, about 1,000 mW to about 17,000 mW, about 1,000 mW to about 18,000 mW, about 1,000 mW to about 19,000 mW, about 1 mW, about 1,000 mW to about 9,000 mW, about 2,000 mW to about 3,000 mW, about 2,000 mW to about 4,000 mW, about 2,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about 5,000 mW, about 3,000 mW to about 6,000 mW, about 3,000 mW to about 7,000 mW, about 3,000 mW to about 8,000 mW, about 3,000 mW to about 9,000 mW, about 4,000 mW to about 5,000 mW, about 4,000 mW to about 6,000 mW, about 4,000 mW to about 7,000 mW, about 4,000 mW to about 8,000 mW, about 4,000 mW to about 9,000 mW, about 5,000 mW to about The power supply voltage may be selected from the group consisting of: 1,000 mW to about 6,000 mW, 1,000 mW to about 7,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, or 1,000 mW to about 9,000 mW.

[0217] In various aspects of these embodiments, the disclosed method of improving vascular hemodynamics includes infrared light comprising: about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30 J / cm 2 About 150 J / cm 2, the total energy incident during the treatment process is about 0.5 kJ to about 6 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for improving vascular hemodynamics includes infrared light having a total power of about 900 mW to about 8,100 mW on the body area. In other aspects of these embodiments, the disclosed method for improving vascular hemodynamics also includes direct current stimulation therapy to the body area. Both photobiomodulation therapy and direct current stimulation therapy can be applied using the photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed method for improving vascular hemodynamics can include a single treatment process or multiple treatment processes, such as about 2 to about 5 treatment processes, about 2 to about 10 treatment processes, about 2 to about 15 treatment processes, about 2 to about 20 treatment processes, about 5 to about 10 treatment processes, about 5 to about 15 treatment processes, about 5 to about 20 treatment processes, about 10 to about 15 treatment processes, about 10 to about 20 treatment processes, or about 15 to about 20 treatment processes.

[0218] In various aspects of these embodiments, the disclosed method of improving vascular hemodynamics includes infrared light comprising: about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30 J / cm 2 About 150 J / cm 2 , the total energy incident during the treatment process is about 1.5 kJ to about 3.5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for improving vascular hemodynamics includes infrared light having a total power of about 1,000 mW to about 8,400 mW on the body area. In other aspects of these embodiments, the disclosed method for improving vascular hemodynamics also includes direct current stimulation therapy to the body area. Both photobiomodulation therapy and direct current stimulation therapy can be applied using the photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed method for improving vascular hemodynamics can include a single treatment process or multiple treatment processes, such as about 2 to about 5 treatment processes, about 2 to about 10 treatment processes, about 2 to about 15 treatment processes, about 2 to about 20 treatment processes, about 5 to about 10 treatment processes, about 5 to about 15 treatment processes, about 5 to about 20 treatment processes, about 10 to about 15 treatment processes, about 10 to about 20 treatment processes, or about 15 to about 20 treatment processes.

[0219] In various aspects of these embodiments, the disclosed method of improving vascular hemodynamics includes infrared light comprising: about 250 mW / cm2 To about 300mW / cm 2 The average irradiance range is about 150 J / cm 2 To about 200J / cm 2 , the total energy incident during the treatment process is about 4kJ to about 5kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for improving vascular hemodynamics includes infrared light having a total power of about 3,000mW to about 8,400mW on the body area. In other aspects of these embodiments, the disclosed method for improving vascular hemodynamics also includes direct current stimulation therapy to the body area. Both photobiomodulation therapy and direct current stimulation therapy can be applied using the photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed method for improving vascular hemodynamics can include a single treatment process or multiple treatment processes, such as about 2 to about 5 treatment processes, about 2 to about 10 treatment processes, about 2 to about 15 treatment processes, about 2 to about 20 treatment processes, about 5 to about 10 treatment processes, about 5 to about 15 treatment processes, about 5 to about 20 treatment processes, about 10 to about 15 treatment processes, about 10 to about 20 treatment processes, or about 15 to about 20 treatment processes.

[0220] The present specification discloses a method for improving the redox activity of cytochrome c oxidase in an individual using photobiomodulation therapy, the method comprising exposing a body area to infrared light of a photobiomodulation therapy garment disclosed herein for one or more treatment processes. In various aspects of these embodiments, the disclosed method for improving the redox activity of cytochrome c oxidase comprises exposing a body area, the body area comprising a torso area, an arm area, a leg area, or any combination thereof. Non-limiting examples of torso areas include an abdominal area, a back area, a shoulder area, or any combination thereof. Non-limiting examples of arm areas include an upper arm area, a forearm area, or a hand. Non-limiting examples of leg areas include a thigh area, a calf area, or a foot.

[0221] In some embodiments, the disclosed methods of improving the redox activity of cytochrome c oxidase include exposing a head region comprising, for example, an area of ​​about 10 cm 2 To about 25cm 2 , about 10cm 2 To about 50cm 2 , about 10cm 2 To about 75cm 2 , about 10cm 2 To about 100cm 2 , about 10cm 2 About 125cm 2, about 10cm 2 About 150cm 2 , about 10cm 2 About 175cm 2 , about 10cm 2 To about 200cm 2 , about 10cm 2 To about 225cm 2 , about 10cm 2 To about 250cm 2 , about 10cm 2 To about 275cm 2 , about 10cm 2 To about 300cm 2 、Approx. 25cm 2 To about 50cm 2 、Approx. 25cm 2 To about 75cm 2 、Approx. 25cm 2 To about 100cm 2 、Approx. 25cm 2 About 125cm 2 、Approx. 25cm 2 About 150cm 2 , about 25cm2 to about 175cm 2 、Approx. 25cm 2 To about 200cm 2 、Approx. 25cm 2 To about 225cm 2 、Approx. 25cm 2 To about 250cm 2 、Approx. 25cm 2 To about 275cm 2 、Approx. 25cm 2 To about 300cm 2 、Approx. 50cm 2 To about 75cm 2 、Approx. 50cm 2 To about 100cm 2 、Approx. 50cm 2 About 125cm 2 、Approx. 50cm 2 About 150cm 2 、Approx. 50cm 2 About 175cm 2 、Approx. 50cm 2 To about 200cm 2 、Approx. 50cm 2 To about 225cm 2 、Approx. 50cm 2 To about 250cm 2、About 50cm 2 To about 275cm 2 、About 50cm 2 To about 300cm 2 、Approx. 75cm 2 To about 100cm 2 、Approx. 75cm 2 About 125cm 2 、Approx. 75cm 2 About 150cm 2 、Approx. 75cm 2 About 175cm 2 、Approx. 75cm 2 To about 200cm 2 、Approx. 75cm 2 To about 225cm 2 、Approx. 75cm 2 To about 250cm 2 、Approx. 75cm 2 To about 275cm 2 、Approx. 75cm 2 To about 300cm 2 , about 100cm 2 About 125cm 2 , about 100cm 2 About 150cm 2 , about 100cm 2 About 175cm 2 , about 100cm 2 To about 200cm 2 , about 100cm 2 To about 225cm 2 , about 100cm 2 To about 250cm 2 , about 100cm 2 To about 275cm 2 or about 100cm 2 To about 300cm 2 .

[0222] In some embodiments, the disclosed methods for improving cytochrome c oxidase redox activity may include a single treatment course or multiple treatment courses. In various aspects of these embodiments, the disclosed methods for improving cytochrome c oxidase redox activity include, for example, about 1 to about 5 treatment courses, about 1 to about 10 treatment courses, about 1 to about 15 treatment courses, about 1 to about 20 treatment courses, about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses. In other aspects of these embodiments, the disclosed methods for improving cytochrome c oxidase redox activity may include multiple treatment courses that last for months or years.

[0223] In some embodiments, the disclosed methods of improving cytochrome c oxidase redox activity comprise exposing a region of the head to infrared light for, e.g., about 5 minutes to about 10 minutes, about 5 minutes to about 15 minutes, about 5 minutes to about 20 minutes, about 5 minutes to about 25 minutes, about 5 minutes to about 30 minutes, about 5 minutes to about 35 minutes, about 5 minutes to about 40 minutes, about 10 minutes to about 15 minutes, about 10 minutes to about 20 minutes, about 10 minutes to about 25 minutes, about 10 minutes to about 30 minutes, about 10 minutes to about 35 minutes, about 10 minutes to about 40 minutes, about 15 minutes to about 20 minutes, about 15 minutes to about 25 minutes, about 15 minutes to about 30 minutes, about 15 minutes to about 35 minutes, or about 15 minutes to about 40 minutes, during the course of treatment.

[0224] In some embodiments, the disclosed methods for improving the redox activity of cytochrome c oxidase include infrared light having an average irradiance range of, for example, about 50 mW / cm 2 About 100mW / cm 2 , about 50mW / cm 2 to about 150mW / cm 2 , about 50mW / cm 2 About 200mW / cm 2 , about 50mW / cm 2 to about 250mW / cm 2 , about 50mW / cm 2 About 300mW / cm 2 , about 100mW / cm 2 to about 150mW / cm 2 , about 100mW / cm 2 About 200mW / cm2 , about 100mW / cm 2 to about 250mW / cm 2 , about 100mW / cm 2 To about 300mW / cm 2 , about 150mW / cm 2 About 200mW / cm 2 , about 150mW / cm 2 to about 250mW / cm 2 , about 150mW / cm 2 To about 300mW / cm 2 , about 200mW / cm 2 to about 250mW / cm 2 , about 200mW / cm 2 To about 300mW / cm 2 or about 250mW / cm 2 To about 300mW / cm 2 .

[0225] In some embodiments, the disclosed methods of improving cytochrome c oxidase redox activity include infrared light comprising an average light flux of, for example, about 30 J / cm2 over a body region. 2 To about 50J / cm 2 , about 30J / cm 2 To about 75J / cm 2 , about 30J / cm 2 To about 100 J / cm 2 , about 30J / cm 2 To about 125J / cm 2 , about 30J / cm 2 About 150 J / cm 2 , about 50J / cm 2 To about 75J / cm 2 , about 50J / cm 2 To about 100 J / cm 2 , about 50J / cm 2 To about 125J / cm 2 , about 50J / cm 2 About 150 J / cm 2 , about 75J / cm 2 To about 100 J / cm 2 , about 75J / cm 2 To about 125J / cm 2 , about 75J / cm 2 About 150 J / cm 2 , about 100J / cm 2To about 125J / cm 2 , about 100J / cm 2 About 150 J / cm 2 or about 100 J / cm 2 About 150 J / cm 2 .

[0226] In some embodiments, the disclosed methods of improving cytochrome c oxidase redox activity include infrared light including a total energy incident during the treatment process of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ , about 1.0 kJ to about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ From about 2.5 kJ to about 2.5 kJ, from about 2.0 kJ to about 3.0 kJ, from about 2.0 kJ to about 3.5 kJ, from about 2.0 kJ to about 4.0 kJ, from about 2.0 kJ to about 4.5 kJ, from about 2.0 kJ to about 5.0 kJ, from about 2.0 kJ to about 5.5 kJ, from about 2.0 kJ to about 6 kJ, from about 2.5 kJ to about 3.0 kJ, from about 2.5 kJ to about 3.5 kJ, from about 2.5 kJ to about 4.0 kJ, from about 2.5 kJ to about 4.5 kJ, from about 2.5 kJ to about 5.0 kJ, from about 2.5 kJ to about 5.5 kJ, from about 2.5 kJ to about 6 kJ, from about 3.0 kJ to about 3.5 kJ, from about 3.0 kJ to about 4.0 kJ, from about 3.0 kJ to about 4.5 kJ , about 3.0 kJ to about 5.0 kJ, about 3.0 kJ to about 5.5 kJ, about 3.0 kJ to about 6 kJ, about 3.5 kJ to about 4.0 kJ, about 3.5 kJ to about 4.5 kJ, about 3.5 kJ to about 5.0 kJ, about 3.5 kJ to about 5.5 kJ, about 3.5 kJ to about 6 kJ, about 4.0 kJ to about 4.5 kJ, about 4.0 kJ to about 5.0 kJ, about 4.0 kJ to about 5.5 kJ, about 4.0 kJ to about 6 kJ, about 4.5 kJ to about 5.0 kJ, about 4.5 kJ to about 5.5 kJ, about 4.5 kJ to about 6 kJ, about 5.0 kJ to about 5.5 kJ, about 5.0 kJ to about 6 kJ, or about 5.5 kJ to about 6 kJ.

[0227] In some embodiments, the disclosed methods of improving cytochrome c oxidase redox activity include infrared light including a total power of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW, about 1,000 mW to about 9,000 mW, about 1,000 mW to about 10,000 mW, about 1,000 mW to about 11,000 mW, about 1,000 mW to about 12,000 mW, about 1,000 mW to about 13,000 mW, about 1,000 mW to about 14,000 mW, about 1,000 mW to about 15,000 mW, about 1,000 mW to about 16,000 mW, about 1,000 mW to about 17,000 mW, about 1,000 mW to about 18,000 mW, about 1,000 mW to about 19,000 mW, about 1 about 8,000 mW, about 1,000 mW to about 9,000 mW, about 2,000 mW to about 3,000 mW, about 2,000 mW to about 4,000 mW, about 2,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about mW to about 5,000 mW, about 3,000 mW to about 6,000 mW, about 3,000 mW to about 7,000 mW, about 3,000 mW to about 8,000 mW, about 3,000 mW to about 9,000 mW, about 4,000 mW to about 5,000 mW, about 4,000 mW to about 6,000 mW, about 4,000 mW to about 7,000 mW, about 4,000 mW to about 8,000 mW, about 4,000 mW to about 9,000 mW, about 5, The power supply may be selected from the group consisting of: a) about 5,000 mW to about 6,000 mW, b) about 5,000 mW to about 7,000 mW, c) about 5,000 mW to about 8,000 mW, d) about 5,000 mW to about 9,000 mW, d) about 6,000 mW to about 7,000 mW, d) about 6,000 mW to about 8,000 mW, d) about 6,000 mW to about 9,000 mW, d) about 7,000 mW to about 8,000 mW, d) about 7,000 mW to about 9,000 mW, or d) about 8,000 mW to about 9,000 mW.

[0228] In various aspects of these embodiments, the disclosed method of improving the redox activity of cytochrome c oxidase comprises infrared light comprising the following: about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30 J / cm 2 About 150 J / cm 2, the total energy incident during the treatment process is about 0.5 kJ to about 6 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity includes infrared light having a total power of about 900 mW to about 8,100 mW on a body area. In still other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity also includes direct current stimulation therapy to a body area. Both photobiomodulation therapy and direct current stimulation therapy can be applied using the photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods for improving cytochrome c oxidase redox activity can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0229] In various aspects of these embodiments, the disclosed method of improving the redox activity of cytochrome c oxidase comprises infrared light comprising the following: about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30 J / cm 2 About 150 J / cm 2 , the total energy incident during the treatment process is about 1.5 kJ to about 3.5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity includes infrared light having a total power of about 1,000 mW to about 8,400 mW on a body area. In still other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity also includes direct current stimulation therapy to the body area. Both photobiomodulation therapy and direct current stimulation therapy can be applied using the photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods for improving cytochrome c oxidase redox activity can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0230] In various aspects of these embodiments, the disclosed method of improving the redox activity of cytochrome c oxidase comprises infrared light comprising: about 250 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 150 J / cm 2 About 200 J / cm 2 , the total energy incident during the treatment process is about 4 kJ to about 5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity includes infrared light having a total power of about 3,000 mW to about 8,400 mW on a body area. In still other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity also includes direct current stimulation therapy to the body area. Both photobiomodulation therapy and direct current stimulation therapy can be applied using the photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods for improving cytochrome c oxidase redox activity can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0231] The present specification discloses a method of improving enteric nervous system activity of an individual using photobiomodulation therapy, the method comprising exposing a torso region to infrared light of a photobiomodulation therapy garment disclosed herein for one or more treatment sessions. Non-limiting examples of torso regions include an abdominal region, a back region, a shoulder region, or any combination thereof.

[0232] In some embodiments, the disclosed methods of improving enteric nervous system activity include exposing a head region including, for example, an area of ​​about 10 cm 2 To about 25cm 2 , about 10cm 2 To about 50cm 2 , about 10cm 2 To about 75cm 2 , about 10cm 2 To about 100cm 2 , about 10cm 2 About 125cm 2 , about 10cm 2 About 150cm 2 , about 10cm 2About 175cm 2 , about 10cm 2 To about 200cm 2 , about 10cm 2 To about 225cm 2 , about 10cm 2 to about 250cm2, about 10cm2 to about 275cm 2 , about 10cm 2 To about 300cm2, about 25cm 2 To about 50cm 2 、Approx. 25cm 2 To about 75cm 2 、Approx. 25cm 2 To about 100cm 2 、Approx. 25cm 2 About 125cm 2 、Approx. 25cm 2 About 150cm 2 、Approx. 25cm 2 About 175cm 2 、Approx. 25cm 2 To about 200cm 2 、Approx. 25cm 2 To about 225cm 2 、Approx. 25cm 2 To about 250cm 2 、Approx. 25cm 2 To about 275cm 2 、Approx. 25cm 2 To about 300cm 2 、About 50cm 2 To about 75cm 2 、About 50cm 2 To about 100cm 2 、About 50cm 2 About 125cm 2 、About 50cm 2 About 150cm 2 、About 50cm 2 About 175cm 2 、About 50cm 2 To about 200cm 2 、About 50cm 2 To about 225cm 2 、About 50cm 2 To about 250cm 2 、About 50cm 2 To about 275cm 2 、About 50cm 2 To about 300cm 2 、Approx. 75cm2 To about 100cm 2 、Approx. 75cm 2 About 125cm 2 、Approx. 75cm 2 About 150cm 2 、Approx. 75cm 2 About 175cm 2 、Approx. 75cm 2 To about 200cm 2 、Approx. 75cm 2 To about 225cm 2 、Approx. 75cm 2 To about 250cm 2 、Approx. 75cm 2 To about 275cm 2 、Approx. 75cm 2 To about 300cm 2 , about 100cm 2 About 125cm 2 , about 100cm 2 About 150cm 2 , about 100cm 2 About 175cm 2 , about 100cm 2 To about 200cm 2 , about 100cm 2 To about 225cm 2 , about 100cm 2 To about 250cm 2 , about 100cm 2 To about 275cm 2 or about 100cm 2 To about 300cm 2 .

[0233] In some embodiments, the disclosed method of improving enteric nervous system activity may include a single treatment course or multiple treatment courses. In various aspects of these embodiments, the disclosed method of improving enteric nervous system activity includes, for example, about 1 to about 5 treatment courses, about 1 to about 10 treatment courses, about 1 to about 15 treatment courses, about 1 to about 20 treatment courses, about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses. In other aspects of these embodiments, the disclosed method of improving enteric nervous system activity may include multiple treatment courses that last for months or years.

[0234] In some embodiments, the disclosed method of improving enteric nervous system activity comprises exposing the head region to infrared light for, e.g., about 5 minutes to about 10 minutes, about 5 minutes to about 15 minutes, about 5 minutes to about 20 minutes, about 5 minutes to about 25 minutes, about 5 minutes to about 30 minutes, about 5 minutes to about 35 minutes, about 5 minutes to about 40 minutes, about 10 minutes to about 15 minutes, about 10 minutes to about 20 minutes, about 10 minutes to about 25 minutes, about 10 minutes to about 30 minutes, about 10 minutes to about 35 minutes, about 10 minutes to about 40 minutes, about 15 minutes to about 20 minutes, about 15 minutes to about 25 minutes, about 15 minutes to about 30 minutes, about 15 minutes to about 35 minutes, or about 15 minutes to about 40 minutes, during the course of treatment.

[0235] In some embodiments, the disclosed methods of improving enteric nervous system activity include infrared light having an average irradiance range of, for example, about 50 mW / cm 2 About 100mW / cm 2 , about 50mW / cm 2 to about 150mW / cm 2 , about 50mW / cm 2 About 200mW / cm 2 , about 50mW / cm 2 to about 250mW / cm 2 , about 50mW / cm 2 About 300mW / cm 2 , about 100mW / cm 2 to about 150mW / cm 2 , about 100mW / cm 2 About 200mW / cm 2 , about 100mW / cm 2 to about 250mW / cm 2 , about 100mW / cm 2 About 300mW / cm 2 , about 150mW / cm 2 About 200mW / cm 2 , about 150mW / cm 2 to about 250mW / cm 2 , about 150mW / cm 2 About 300mW / cm 2 , about 200mW / cm 2 to about 250mW / cm 2 , about 200mW / cm 2 About 300mW / cm 2or about 250mW / cm 2 To about 300mW / cm 2 .

[0236] In some embodiments, the disclosed methods of improving enteric nervous system activity include infrared light including an average light flux of, for example, about 30 J / cm 2 To about 50J / cm 2 , about 30J / cm 2 To about 75J / cm 2 , about 30J / cm 2 To about 100 J / cm 2 , about 30J / cm 2 To about 125J / cm 2 , about 30J / cm 2 About 150 J / cm 2 , about 50J / cm 2 To about 75J / cm 2 , about 50J / cm 2 To about 100 J / cm 2 , about 50J / cm 2 To about 125J / cm 2 , about 50J / cm 2 About 150 J / cm 2 , about 75J / cm 2 To about 100 J / cm 2 , about 75J / cm 2 To about 125J / cm 2 , about 75J / cm 2 About 150 J / cm 2 , about 100J / cm 2 To about 125J / cm 2 , about 100J / cm 2 About 150 J / cm 2 or about 100 J / cm 2 About 150 J / cm 2 .

[0237] In some embodiments, the disclosed methods of improving enteric nervous system activity include infrared light including a total energy incident during the treatment process of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about 2 kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, From about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0238] In some embodiments, the disclosed methods of improving enteric nervous system activity include infrared light including a total power of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW, about 1,000 mW to about 9,000 mW, about 1,000 mW to about 10,000 mW, about 1,000 mW to about 11,000 mW, about 1,000 mW to about 12,000 mW, about 1,000 mW to about 13,000 mW, about 1,000 mW to about 14,000 mW, about 1,000 mW to about 15,000 mW, about 1,000 mW to about 16,000 mW, about 1,000 mW to about 17,000 mW, about 1,000 mW to about 18,000 mW, about 1,000 mW to about 19,000 mW, about 1 mW, about 1,000 mW to about 9,000 mW, about 2,000 mW to about 3,000 mW, about 2,000 mW to about 4,000 mW, about 2,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about 5,000 mW, about 3,000 mW to about 6,000 mW, about 3,000 mW to about 7,000 mW, about 3,000 mW to about 8,000 mW, about 3,000 mW to about 9,000 mW, about 4,000 mW to about 5,000 mW, about 4,000 mW to about 6,000 mW, about 4,000 mW to about 7,000 mW, about 4,000 mW to about 8,000 mW, about 4,000 mW to about 9,000 mW, about 5,000 mW to about The power supply voltage may be selected from the group consisting of: 1,000 mW to about 6,000 mW, 1,000 mW to about 7,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, 1,000 mW to about 8,000 mW, 1,000 mW to about 9,000 mW, or 1,000 mW to about 9,000 mW.

[0239] In various aspects of these embodiments, the disclosed method of improving enteric nervous system activity comprises infrared light comprising: about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30 J / cm 2 About 150 J / cm 2, the total energy incident during the treatment process is about 0.5kJ to about 6kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving enteric nervous system activity includes infrared light, which includes a total power of about 900mW to about 8,100mW on the torso area. In other aspects of these embodiments, the disclosed method of improving enteric nervous system activity also includes direct current stimulation therapy to the torso area. Both photobiomodulation therapy and direct current stimulation therapy can be applied using the photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed methods for improving enteric nervous system activity can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0240] In various aspects of these embodiments, the disclosed method of improving enteric nervous system activity comprises infrared light comprising: about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30 J / cm 2 About 150 J / cm 2 , the total energy incident during the treatment process is about 1.5 kJ to about 3.5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving enteric nervous system activity includes infrared light, which includes a total power of about 1,000 mW to about 8,400 mW on the torso area. In still other aspects of these embodiments, the disclosed method of improving enteric nervous system activity also includes direct current stimulation therapy to the torso area. Both photobiomodulation therapy and direct current stimulation therapy can be applied using the photobiomodulation therapy garment disclosed herein. In other aspects of these embodiments, the disclosed methods for improving enteric nervous system activity can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0241] In various aspects of these embodiments, the disclosed method of improving enteric nervous system activity comprises infrared light comprising: about 250 mW / cm2 About 300mW / cm 2 The average irradiance range is about 150 J / cm 2 About 200 J / cm 2 , the total energy incident during the treatment process is about 4kJ to about 5kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving enteric nervous system activity includes infrared light, which includes a total power of about 3,000mW to about 8,400mW on the torso area. In still other aspects of these embodiments, the disclosed method of improving enteric nervous system activity also includes direct current stimulation therapy to the torso area. Both photobiomodulation therapy and direct current stimulation therapy can be applied using the photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed methods for improving enteric nervous system activity can comprise a single treatment course or multiple treatment courses, e.g., about 2 to about 5 treatment courses, about 2 to about 10 treatment courses, about 2 to about 15 treatment courses, about 2 to about 20 treatment courses, about 5 to about 10 treatment courses, about 5 to about 15 treatment courses, about 5 to about 20 treatment courses, about 10 to about 15 treatment courses, about 10 to about 20 treatment courses, or about 15 to about 20 treatment courses.

[0242] In some embodiments, the photobiomodulation therapy garment disclosed herein is used as the sole treatment device. In some embodiments, the photobiomodulation therapy garment disclosed herein is used in combination with another therapy. In some embodiments, the photobiomodulation therapy garment disclosed herein is used in combination with another cognitive behavioral therapy.

[0243] In some embodiments, the photobiomodulation therapy garments disclosed herein are used in combination with another photobiomodulation therapy (e.g., high power irradiance photobiomodulation therapy). In some embodiments, the photobiomodulation therapy garments disclosed herein are used in combination with another photobiomodulation therapy (e.g., high power irradiance photobiomodulation therapy). 2 or less irradiance, combined with low-power transcranial photobiomodulation therapy using photobiomodulation therapy clothing capable of delivering approximately 250 mW / cm 2In some embodiments, high-power transcranial photobiomodulation therapy is performed on an individual using a fixed device with an irradiance of 100 % or more. In some embodiments, high-power transcranial photobiomodulation therapy is performed in a clinical or other healthcare facility setting, while low-power photobiomodulation therapy is performed in a non-clinical setting (e.g., at home, in a park, or while traveling by public transportation). In some embodiments, low-power transcranial photobiomodulation therapy is used to enhance the effectiveness of high-power transcranial photobiomodulation therapy and improve the treatment of depression and depressive symptoms in an individual. In some embodiments, the circadian rhythm-based timed administration disclosed herein will be used to time the administration of high-power transcranial photobiomodulation therapy, low-power transcranial photobiomodulation therapy, or both.

[0244] In some embodiments, the photobiomodulation therapy garment disclosed herein is used in combination with transcranial magnetic stimulation (TMS). In some embodiments, an individual undergoes TMS in combination with low-power transcranial photobiomodulation therapy using a photobiomodulation therapy garment disclosed herein having the following items: capable of applying about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , a total energy incident during the treatment process of about 0.5 kJ to about 6 kJ, a total power over the head area of ​​about 900 mW to about 8,100 mW, or any combination thereof. In some embodiments, an individual undergoes TMS in combination with low-power transcranial photobiomodulation therapy using a photobiomodulation therapy garment disclosed herein having the following items: capable of applying about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , a total energy incident during the treatment process of about 1.5 kJ to about 3.5 kJ, a total power over the head area of ​​about 1,000 mW to about 8,400 mW, or any combination thereof. In some embodiments, an individual undergoes TMS in combination with low-power transcranial photobiomodulation therapy using a photobiomodulation therapy garment disclosed herein having the following items: capable of applying about 250 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 150 J / cm 2 About 200 J / cm 2, the total energy incident during the treatment process is about 4 kJ to about 5 kJ, the total power over the head area is about 3,000 mW to about 8,400 mW, or any combination thereof. In some embodiments, TMS is performed in a clinical or other healthcare facility setting, while low-power photobiomodulation therapy is performed in a non-clinical setting (e.g., at home, in a park, or while traveling by public transportation). In some embodiments, low-power transcranial photobiomodulation therapy is used to enhance the effectiveness of TMS and improve the treatment of depression and depressive symptoms in individuals. In some embodiments, the circadian rhythm-based timed administration disclosed herein will be used to time the administration of TMS, low-power transcranial photobiomodulation therapy, or both.

[0245] In some embodiments, the photobiomodulation therapy garments disclosed herein are used in conjunction with evidence-based mental health practices. In some embodiments, individuals experience a decrease in the intensity of light emitted by a photobiomodulation therapy garment as disclosed herein. 2 or less irradiance of photobiomodulation therapy clothing combined with low-power transcranial photobiomodulation therapy in an evidence-based mental health practice. Evidence-based mental health practices include, but are not limited to, evidence-based psychotherapy (EBT), cognitive behavioral therapy (CBT), dialectical behavioral therapy (DBT), exposure therapy, functional family therapy (FFT), assertive community therapy (ACT), acceptance and commitment therapy (ACT), prolonged exposure therapy (PE), cognitive training and rehabilitation, and motivational interviewing (MI). In some embodiments, the evidence-based mental health practice is performed by a therapist in a clinical or other health care facility setting, while the low-power photobiomodulation therapy is performed in a non-clinical setting (e.g., at home, in a park, or while traveling by transportation). In some embodiments, the evidence-based mental health practice is performed by a therapist in a virtual environment, while the low-power photobiomodulation therapy is performed in a non-clinical setting (e.g., at home, in a park, or while traveling by transportation). In some embodiments, the evidence-based mental health practice is a digital-based artificial intelligence (AI) therapy, while the low-power photobiomodulation therapy is performed in a non-clinical setting (e.g., at home, in a park, or while traveling by transportation). In some embodiments, low-power transcranial photobiomodulation therapy is used to enhance the effectiveness of evidence-based mental health practices and improve the treatment of depression and depressive symptoms in individuals. In some embodiments, the circadian rhythm-based timing of administration disclosed herein will be used to time the administration of evidence-based mental health practices, low-power transcranial photobiomodulation therapy, or both.

[0246] In some embodiments, the photobiomodulation therapy garment disclosed herein is used in combination with ocular light therapy (e.g., bright light therapy or blue light therapy). In some embodiments, an individual undergoes ocular light therapy in combination with transcranial photobiomodulation therapy using a photobiomodulation therapy garment disclosed herein having the following items: capable of applying about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , a total energy incident during the treatment process of about 0.5 kJ to about 6 kJ, a total power over the head region of about 900 mW to about 8,100 mW, or any combination thereof. In some embodiments, an individual undergoes ocular light therapy in combination with transcranial photobiomodulation therapy using a photobiomodulation therapy garment disclosed herein having the following items: capable of applying about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , a total energy incident during the treatment process of about 1.5 kJ to about 3.5 kJ, a total power over the head region of about 1,000 mW to about 8,400 mW, or any combination thereof. In some embodiments, an individual undergoes ocular light therapy in conjunction with transcranial photobiomodulation therapy using a photobiomodulation therapy garment disclosed herein having the following items: capable of applying about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , the total energy incident during the treatment process is about 0.5kJ to about 6kJ, the total power on the head area is about 900mW to about 8,100mW, or any combination thereof. In some embodiments, transcranial photobiomodulation therapy can be administered daily during ocular light therapy and / or between each of two or more ocular light therapy sessions. In some embodiments, transcranial photobiomodulation therapy is used to enhance the effectiveness of ocular light therapy by enhancing relaxation, calmness, and well-being. In some embodiments, the circadian rhythm-based timed administration disclosed herein will be used to time the administration of ocular light therapy, transcranial photobiomodulation therapy, or both.

[0247] In some embodiments, the photobiomodulation therapy garment disclosed herein is used in conjunction with mindfulness therapy. In some embodiments, an individual practices mindfulness therapy in conjunction with transcranial photobiomodulation therapy using the photobiomodulation therapy garment disclosed herein having the following items: capable of applying about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , a total energy incident during the treatment process of about 0.5 kJ to about 6 kJ, a total power over the head area of ​​about 900 mW to about 8,100 mW, or any combination thereof. In some embodiments, an individual practices mindfulness therapy in conjunction with transcranial photobiomodulation therapy using a photobiomodulation therapy garment disclosed herein having the following items: capable of applying about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , a total energy incident during the treatment process of about 1.5 kJ to about 3.5 kJ, a total power over the head area of ​​about 1,000 mW to about 8,400 mW, or any combination thereof. In some embodiments, an individual practices mindfulness therapy in conjunction with transcranial photobiomodulation therapy using a photobiomodulation therapy garment disclosed herein having the following items: capable of applying about 50 mW / cm 2 About 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , the total energy incident during the treatment process is about 0.5kJ to about 6kJ, the total power on the head area is about 900mW to about 8,100mW, or any combination thereof. In some embodiments, transcranial photobiomodulation therapy can be administered daily during mindfulness therapy and / or between each of two or more mindfulness therapies. In some embodiments, transcranial photobiomodulation therapy is used to enhance the effectiveness of mindfulness therapy by enhancing relaxation, calmness, and well-being. In some embodiments, the circadian rhythm-based timed administration disclosed herein will be used to time the administration of mindfulness therapy, transcranial photobiomodulation therapy, or both.

[0248] In some embodiments, the photobiomodulation therapy apparel disclosed herein is used in conjunction with meditation therapy. In some embodiments, an individual practices meditation therapy in conjunction with transcranial photobiomodulation therapy using the photobiomodulation therapy apparel disclosed herein having the following items: capable of applying about 50 mW / cm2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , a total energy incident during the treatment process of about 0.5 kJ to about 6 kJ, a total power over the head area of ​​about 900 mW to about 8,100 mW, or any combination thereof. In some embodiments, an individual practices meditation therapy in conjunction with transcranial photobiomodulation therapy using a photobiomodulation therapy garment disclosed herein having the following items: capable of applying about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , a total energy incident during the treatment process of about 1.5 kJ to about 3.5 kJ, a total power over the head area of ​​about 1,000 mW to about 8,400 mW, or any combination thereof. In some embodiments, an individual practices meditation therapy in conjunction with transcranial photobiomodulation therapy using a photobiomodulation therapy garment disclosed herein having the following items: capable of applying about 50 mW / cm 2 To about 300mW / cm 2 The average irradiance range is about 30J / cm 2 About 150 J / cm 2 , the total energy incident during the treatment process is about 0.5kJ to about 6kJ, the total power on the head area is about 900mW to about 8,100mW, or any combination thereof. In some embodiments, transcranial photobiomodulation therapy can be administered daily during meditation therapy and / or between each of two or more meditation therapies. In some embodiments, transcranial photobiomodulation therapy is used to enhance the effectiveness of meditation therapy by enhancing relaxation, calmness, and well-being. In some embodiments, the circadian rhythm-based timed administration disclosed herein will be used to time the administration of meditation therapy, transcranial photobiomodulation therapy, or both.

[0249] In some embodiments, photobiomodulation therapy using the photobiomodulation therapy garment disclosed herein, whether alone or in combination with another therapy, is administered based on the individual's circadian rhythm. In some embodiments, the individual uses the photobiomodulation therapy garment disclosed herein for transcranial photobiomodulation therapy in the morning (e.g., between 6 a.m. and 10 a.m.). In some embodiments, the individual uses the photobiomodulation therapy garment disclosed herein for transcranial photobiomodulation therapy in the afternoon / evening (e.g., between 3 p.m. and 7 p.m.). The photobiomodulation therapy garment disclosed herein is capable of administering approximately 20 mW / cm2 To about 500mW / cm 2 Photobiomodulation therapy clothing with an irradiance of will be used in this circadian rhythm-based timing administration. In some embodiments, circadian rhythm-based timing administration will be used to treat depression and depressive symptoms in individuals.

[0250] Various aspects of this specification may also be described by the following examples:

[0251] 1. A photobiomodulation therapy garment worn on a skin surface having an area of ​​interest, the photobiomodulation therapy garment comprising: a flexible outer sheet, a flexible inner sheet, a flexible circuit board, a near-infrared light source, and a controller, the flexible inner sheet having a portion allowing near-infrared light to pass therethrough, the inner sheet being configured to face the skin surface; the flexible circuit board being positioned between the outer sheet and the inner sheet; the near-infrared light source being mounted on the flexible circuit board and aligned with a portion of the flexible inner sheet, the near-infrared light source being configured to emit near-infrared light having a wavelength between 600 nm and 1600 nm and having a predetermined dose measurement value directed to the area of ​​interest on the skin surface during photobiomodulation therapy; the controller having a processor and a memory, the controller being in electrical communication with the near-infrared light source via the flexible circuit board, the processor and the memory being configured with executable instructions for controlling one or more of the light source operation time, the light source luminous flux level, the light source irradiance level, the light source pulse operation, and the light source continuous operation.

[0252] 2. The photobiomodulation therapy garment of embodiment 1, wherein the near infrared light source is part of a group of near infrared light sources arranged on a flexible circuit board and configured to be directed toward an area of ​​interest on a skin surface during photobiomodulation therapy.

[0253] 3. A photobiomodulation therapy garment according to embodiment 1 or 2, wherein the near-infrared light source group is arranged with an intra-group light source spacing of at least 2 mm between the near-infrared light sources, or at least 3 mm between the near-infrared light sources, or at least 4 mm between the near-infrared light sources, or at least 5 mm between the near-infrared light sources, or at least 6 mm between the near-infrared light sources, or at least 7 mm between the near-infrared light sources, or at least 8 mm between the near-infrared light sources, or at least 9 mm between the near-infrared light sources, or at least 10 mm between the near-infrared light sources.

[0254] 4. A photobiomodulation therapy garment according to any one of embodiments 1-...

Claims

1. A photobiomodulation therapy garment comprising: a garment configured to be worn by a user on a skin surface, the garment comprising a first surface and a second surface opposite the first surface, the first surface being configured to face the skin surface once the garment is worn; as well as a photobiomodulation unit integrated within the garment, the photobiomodulation unit comprising a connection terminal, one or more near-infrared light sources, and one or more sensors, the connection terminal being in electronic communication with the one or more near-infrared light sources and the one or more sensors, wherein the one or more near-infrared light sources are low-intensity lasers and are each configured to emit near-infrared light having a wavelength between 800 nm and 1200 nm and having a predetermined dosimetry value; a controller including a processor and a memory, the controller being configured to operably engage the terminal rails of the connection terminal in a manner to establish electronic communication between the controller and the connection terminal; wherein the first surface of the garment comprises a first portion, the first portion comprising one or more light openings, wherein each of the one or more near-infrared light sources is operatively aligned with the one or more light openings to allow near-infrared light from the one or more near-infrared light sources to properly pass through the one or more light openings, wherein the first surface of the garment includes a second portion, the second portion including one or more sensor openings, wherein each of the one or more sensors is operatively aligned with the one or more sensor openings to allow the one or more sensors to properly operate through the one or more sensor openings, and The processor and the memory are configured with executable instructions for independently controlling each of the one or more near-infrared light sources and each of the one or more sensors.

2. The photobiomodulation therapy garment according to claim 1, wherein: The garment is configured to wrap around or conform to a body region, with the ability to be moved from one body region to another on the body.

3. The photobiomodulation therapy garment according to claim 1 or 2, wherein: The size and specifications of the garments are determined to fit specific body parts in particular.

4. The photobiomodulation therapy garment according to any one of claims 1 to 3, wherein: Each of the one or more sensors is configured to detect and collect information about one or more parameters of the garment, the photobiomodulation unit and components therein, the controller and components therein, and a user, and then transmit the information to the controller.

5. The photobiomodulation therapy garment according to claim 4, wherein: The one or more parameters include operational information of the garment, the photobiomodulation unit and components therein, and the controller and components therein, biometric information about a user, or any combination of these items.

6. The photobiomodulation therapy garment according to any one of claims 1 to 5, wherein: The executable instructions independently control each of the one or more near infrared light sources.

7. The photobiomodulation therapy garment of claim 6, wherein: The executable instructions control the activation, activation duration, deactivation, deactivation duration, activation pattern and timing, deactivation pattern and timing, luminous flux level, irradiance level, dosimetry level, pulsed operation, continuous operation, operation time, cycle duration, or any combination of these for each of the one or more near-infrared light sources.

8. The photobiomodulation therapy garment according to any one of claims 1 to 7, wherein: The executable instructions independently control each of the one or more sensors.

9. The photobiomodulation therapy garment of claim 8, wherein: The executable instructions control the collection and analysis of information from each of the one or more sensors.

10. The photobiomodulation therapy garment according to any one of claims 1 to 9, wherein: The one or more near-infrared light sources are a plurality of spaced-apart near-infrared light sources.

11. The photobiomodulation therapy garment of claim 10, wherein: The plurality of near-infrared light sources are arranged in a plurality of spaced-apart near-infrared light source groups, each of the plurality of near-infrared light source groups including a plurality of near-infrared light sources.

12. The photobiomodulation therapy garment of any one of claims 1-11, further comprising one or more stimulators.

13. The photobiomodulation therapy garment of claim 12, wherein: The one or more stimulators include components capable of generating direct current or a magnetic field.

14. The photobiomodulation therapy garment of claim 13, wherein: The one or more stimulators that generate direct current are transcranial direct current stimulators.

15. The photobiomodulation therapy garment according to any one of claims 1 to 14, wherein: The processor and the memory are configured with executable instructions for dynamically controlling each of the one or more near infrared light sources and each of the one or more sensors.

16. The photobiomodulation therapy garment according to any one of claims 1 to 15, wherein: The skin surface includes the forehead area, the neck area clothing, the back of the neck area, the shoulder area, the wrist area, the abdomen area, the back area or any combination of these items.

17. The photobiomodulation therapy garment of claim 16, wherein: The frontal area includes the dorsolateral prefrontal cortex area, the frontal eye movement area, or both.

18. The photobiomodulation therapy garment of claim 16, wherein: The forehead site includes Fp1 site, Fpz site, Fp2 site, F3 site, Fz site, F4 site or any combination of these items.

Images