Functional material containing composite hydroxyapatite for relieving dry mouth and halitosis of middle-aged and elderly people and preparation method of functional material

Abstract

The invention relates to a composite hydroxyapatite-containing functional material for relieving dry mouth and ozostomia of middle-aged and elderly people and a preparation method thereof, and belongs to the technical field of dental oral care. Comprising the following raw materials in parts by weight: 10 to 15 parts of deionized water, 0.1 to 0.3 part of a sweetening agent, 2 to 3 parts of a surfactant, 3 to 5 parts of glycerol, 30 to 35 parts of a humectant, 0.6 to 1 part of a thickening agent, 3 to 5 parts of trehalose, 25 to 35 parts of composite hydroxyapatite, 0.1 to 0.2 part of superoxide dismutase and 0.1 to 0.2 part of glucanase. The prepared functional material body has a good effect of relieving the dry mouth and ozostomia of the middle-aged and elderly people.

Description

Technical Field

[0001] The invention belongs to the technical field of dental oral care, and relates to a functional material body containing composite hydroxyapatite for alleviating dry mouth and halitosis of middle-aged and elderly people, and a preparation method thereof. Background Art

[0002] As middle-aged and elderly people age, their salivary gland function declines, saliva secretion decreases, and the ability to clean the mouth decreases, making them more susceptible to dry mouth and bad breath. Dry mouth is a symptom caused by a lack of saliva in the mouth. Due to reduced saliva secretion, patients feel dryness in the mouth, a foreign body sensation, and a burning sensation. When chewing food, especially drier food, they cannot form a food bolus, which affects swallowing. The amount of saliva secreted is small, and the flushing effect on the teeth and oral mucosa is also small, making the self-cleaning function of the mouth worse. The production and secretion of saliva are affected by systemic, local, external, and self-factors. Due to metabolic disorders, the types and number of bacteria in the mouth change, which may also cause dry mouth and bad breath.

[0003] When the mouth is dry, food and bacteria adhere to the tooth surface, promoting the formation of plaque. At the same time, the pH value in the mouth decreases, which increases the risk of tooth decay and causes changes in the oral flora. The proportion of pathogenic bacteria related to caries, such as Streptococcus mutans and Actinomycetes, is significantly higher than normal.

[0004] Therefore, a material having the effect of alleviating dry mouth and bad breath in the middle-aged and elderly people is needed. Summary of the invention

[0005] The purpose of the present invention is to provide a functional material body containing composite hydroxyapatite for alleviating dry mouth and bad breath in middle-aged and elderly people and a preparation method thereof. The prepared functional material body has a good effect of alleviating dry mouth and bad breath.

[0006] The purpose of the present invention can be achieved through the following technical solutions: A functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in middle-aged and elderly people, comprising the following raw materials in parts by weight: 10-15 parts of deionized water, 0.1-0.3 parts of sweetener, 2-3 parts of surfactant, 3-5 parts of glycerol, 30-35 parts of moisturizer, 0.6-1 parts of thickener, 3-5 parts of trehalose, 25-35 parts of composite hydroxyapatite, 0.1-0.2 parts of superoxide dismutase and 0.1-0.2 parts of glucanase; The preparation process of the composite hydroxyapatite is as follows: S1. Preparation of hydroxyapatite: S1.1. Dissolve calcium salt in water to prepare a calcium solution with a mass fraction of 10-15%, and adjust the pH value of the solution to 8-10 with alkali to obtain solution A; S1.2, add ammonium dihydrogen phosphate to solution A, heat to 40-60°C, and stir for 30-60 min to obtain solution B, wherein the weight ratio of ammonium dihydrogen phosphate in solution B to solution A is (3-5): (90-100); S1.3, pour solution B into a reactor, stir at 120-150°C for 18-25h, wash the obtained substance with deionized water and anhydrous ethanol, and dry it in a constant temperature drying oven at 55-70°C for 8-12h to obtain hydroxyapatite; S2. Preparation of modified hydroxyapatite: Mix menthol: clove oil: anhydrous ethanol in a volume ratio of (15-20): (4-6): (45-55) to obtain a mixed solution, add hydroxyapatite, stir at 55-65°C for 10-12 hours, then rotary evaporate for 1-2 hours, wash with deionized water, and then dry at 65-75°C for 8-10 hours to obtain modified hydroxyapatite; S3. Preparation of composite hydroxyapatite: The modified hydroxyapatite is dispersed in deionized water, ultrasonically treated for 15 minutes, and then high methoxy pectin is added. After stirring at a speed of 200 r / min for 1-2 hours, hydroxyethyl cellulose is added and the speed is increased to 300-400 r / min and stirring is continued for 2-4 hours. The mixture is dried in a vacuum drying oven at 45-50° C. for 10-14 hours. The obtained solid is ball-milled in a ball mill and then sieved through a 200-mesh sieve to obtain the composite hydroxyapatite, wherein the mass ratio of the modified hydroxyapatite, hydroxyethyl cellulose, high methoxy pectin and deionized water is (15-25):(3-6):(2-5):100.

[0007] As a preferred technical solution of the present invention, the thickener is one of polyvinyl pyrrolidone, xanthan gum and cellulose gum.

[0008] As a preferred technical solution of the present invention, the moisturizing agent is one or both of sorbitol and polyethylene glycol-8.

[0009] As a preferred technical solution of the present invention, the surfactant is one of sodium lauroyl sarcosinate and lauryl alcohol.

[0010] As a preferred technical solution of the present invention, the sweetener is one of saccharin sodium and stevia extract.

[0011] As a preferred technical solution of the present invention, in step S1.1, the calcium salt is one of calcium nitrate tetrahydrate and calcium chloride.

[0012] As a preferred technical solution of the present invention, in step S1.1, the alkali is a sodium hydroxide aqueous solution with a concentration of 1 mol / L.

[0013] As a preferred technical solution of the present invention, in step S2, the weight volume ratio of the hydroxyapatite to the mixed solution is 1: (18-20) g / mL.

[0014] As a preferred technical solution of the present invention, in step S3, the ball milling condition is grinding at a rotation speed of 400 r / min for 3 hours.

[0015] A method for preparing a functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in middle-aged and elderly people, comprising the following preparation process: The sweetener, surfactant and deionized water are fully mixed by weight, stirred and dissolved to obtain a mixture A, and then a humectant, glycerin and a thickener are added, and the mixture is stirred at a speed of 250 r / min for 70 to 100 minutes to obtain a mixture B; after the mixture A and the mixture B are mixed, superoxide dismutase and glucanase are added, and the mixture is stirred at a speed of 350 r / min for 60 to 90 minutes to obtain a mixture C; composite hydroxyapatite and trehalose are continuously added to the mixture C, and the mixture is stirred under vacuum conditions for 30 to 60 minutes to obtain the composite hydroxyapatite-containing functional material body capable of relieving dry mouth and bad breath in the middle-aged and elderly.

[0016] Hydroxyapatite has excellent adsorption properties and can quickly combine with bacteria and halitosis-causing chemicals (such as hydrogen sulfide, methyl mercaptan, etc.) in the mouth, and then expel them together through gargling, thereby cleaning the mouth and reducing halitosis. At the same time, hydroxyapatite can effectively inhibit harmful bacteria in the mouth that cause halitosis, such as porphyromonas gingivalis, spirochetes and other anaerobic bacteria. By inhibiting the growth and reproduction of these harmful bacteria, hydroxyapatite helps prevent and relieve periodontal diseases and further reduce halitosis.

[0017] Menthol can effectively neutralize bad breath, making it fresh and pleasant, while promoting saliva secretion, thereby helping to reduce bacteria in the mouth and relieve bad breath and dry mouth. Clove oil has bactericidal and anti-inflammatory effects, and has a significant inhibitory effect on a variety of pathogenic fungi and bacteria. It can kill or inhibit bacteria in the mouth and reduce the odor produced by bacteria, thereby achieving the effect of removing bad breath.

[0018] The present invention prepares hydroxyapatite by reacting calcium salt with ammonium dihydrogen phosphate under the action of alkali, takes hydroxyapatite as a carrier, and adopts an impregnation method to immerse the hydroxyapatite carrier in a solution containing menthol and clove oil, so that the menthol and clove oil molecules fully penetrate into the interior and surface of the carrier, and at the same time, the organic molecules can be loaded on the porous structure surface of the hydroxyapatite by adsorption. After the menthol, clove oil and hydroxyapatite are combined, they can play a synergistic role to enhance each other's effects, and improve the problem of halitosis more efficiently.

[0019] The modified hydroxyapatite is then treated to obtain composite hydroxyapatite. When hydroxyethyl cellulose molecules are added to the liquid, hydroxyethyl cellulose, as a polymer material, has good film-forming and adhesion properties. Due to the influence of solubility and molecular arrangement, hydroxyethyl cellulose molecules will aggregate to the surface. In terms of surface structure, the hydrophilic nature of the hydroxyl group enables the hydroxyethyl cellulose molecules to quickly form hydrogen bonds with water molecules, thereby forming a uniform distribution on the surface of the modified hydroxyapatite. High methoxy pectin is first added. High methoxy pectin has excellent moisturizing properties and emulsion stability, which can further enhance the film-forming effect and make the film more stable. The molecular structure of high methoxy pectin contains a large number of functional groups such as hydroxyl and carboxyl groups. These functional groups can interact with calcium ions and phosphate ions on the surface of hydroxyapatite. This interaction helps to promote the close combination of the film and hydroxyapatite.

[0020] At the same time, high methoxyl pectin molecules contain more polar groups and have strong hydrophilic properties. Therefore, during use, they have good compatibility with water. During the friction process of composite hydroxyapatite, various components in it are continuously released, thereby increasing the effect of the material in relieving bad breath and dry mouth.

[0021] Superoxide dismutase is an antioxidant ingredient in toothpaste that can remove free radicals in the mouth and protect teeth from oxidative damage. Glucanase can also inhibit the formation of new dental plaque by breaking down glucan, helping to keep teeth clean and bright.

[0022] Trehalose can absorb and lock in moisture, forming a protective layer and reducing moisture evaporation, thereby helping to keep the mouth moist and relieve dry mouth symptoms. Trehalose helps maintain the integrity and stability of oral mucosal cells, enhances the barrier function of the oral mucosa, and further reduces the discomfort caused by dry mouth.

[0023] Beneficial effects of the present invention: The present invention prepares hydroxyapatite by reacting calcium salt and ammonium dihydrogen phosphate under the action of alkali, and modifies the hydroxyapatite by solution impregnation. The prepared composite hydroxyapatite has the effect of relieving dry mouth and bad breath when mixed with other auxiliary agents. DETAILED DESCRIPTION

[0024] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0025] In the following examples and comparative examples: Hydroxyapatite: purchased from Shanghai Kanglang Biotechnology Co., Ltd., product number: KL811001; Saccharin sodium: purchased from Shanghai Huichu Chemical Technology Co., Ltd.; Sodium lauroyl sarcosinate: purchased from Tesco Chemical (Hubei) Co., Ltd.; Sorbitol: purchased from Shandong Yaheng Biotechnology Co., Ltd.; Superoxide dismutase: purchased from Shanghai Huicheng Biotechnology Co., Ltd. Cellulose gum: purchased from Anhui Runtai Biotechnology Co., Ltd.; Calcium nitrate tetrahydrate: purchased from Shanghai Saikerui Biotechnology Co., Ltd.; Ammonium dihydrogen phosphate: purchased from Shanghai Yimiao Chemical Technology Co., Ltd., product number: PA01732; Menthol: purchased from Hubei Xinkang Pharmaceutical Chemical Co., Ltd.; Clove oil: purchased from Fuchen (Tianjin) Chemical Reagent Co., Ltd.; High methoxyl pectin: purchased from Wuhan Nengren Pharmaceutical Chemical Co., Ltd.; Hydroxyethyl cellulose: purchased from Shenzhen Boshun Chemical Co., Ltd. Glycerol: purchased from Nantong Runfeng Petrochemical Co., Ltd.; Glucanase: purchased from Shanghai Yuanye Biotechnology Co., Ltd.; Trehalose: purchased from Shanghai Yuanye Biotechnology Co., Ltd.

[0026] Example 1 Preparation of composite hydroxyapatite: S1. Preparation of hydroxyapatite: S1.1, dissolving calcium nitrate tetrahydrate in water to prepare a calcium-containing solution with a mass fraction of 10%, and adjusting the pH value of the solution to 8 with a sodium hydroxide aqueous solution with a concentration of 1 mol / L to obtain solution A; S1.2, add ammonium dihydrogen phosphate to solution A, heat to 40°C, and stir for 30 minutes to obtain solution B, wherein the weight ratio of ammonium dihydrogen phosphate in solution B to solution A is 3:90; S1.3, pouring solution B into a reaction kettle, stirring at 120°C for 18 hours, washing the obtained substance with deionized water and anhydrous ethanol, and drying in a constant temperature drying oven at 55°C for 8 hours to obtain hydroxyapatite; S2. Preparation of modified hydroxyapatite: Mix menthol: clove oil: anhydrous ethanol in a volume ratio of 15:4:45 to obtain a mixed solution, add hydroxyapatite, wherein the weight volume ratio of hydroxyapatite to the mixed solution is 1:18 g / mL, stir at 55°C for 10 hours, then rotary evaporate for 1 hour, wash with deionized water, and then dry at 65°C for 8 hours to obtain modified hydroxyapatite; S3. Preparation of composite hydroxyapatite: The modified hydroxyapatite is dispersed in deionized water, ultrasonically treated for 15 minutes, and then high methoxy pectin is added. After stirring at a speed of 200 r / min for 1 hour, hydroxyethyl cellulose is added and the speed is increased to 300 r / min and stirring is continued for 2 hours. The mixture is dried in a vacuum drying oven at 45°C for 10 hours, and the obtained solid is ball milled at a speed of 400 r / min for 3 hours and then passed through a 200-mesh sieve to obtain the composite hydroxyapatite, wherein the mass ratio of the modified hydroxyapatite, hydroxyethyl cellulose, high methoxy pectin and deionized water is 15:3:2:100.

[0027] Preparation of a functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the elderly: By weight, 10 parts of deionized water, 0.1 parts of sodium saccharin and 2 parts of sodium lauroyl sarcosinate are fully mixed and stirred to dissolve to obtain a mixture A, and then 3 parts of glycerol, 30 parts of sorbitol and 0.6 parts of cellulose gum are added, and the mixture is stirred at a speed of 250 r / min for 70 minutes to obtain a mixture B; after the mixture A and the mixture B are mixed, 0.1 parts of superoxide dismutase and 0.1 parts of glucanase are added, and the mixture is stirred at a speed of 350 r / min for 60 minutes to obtain a mixture C; 3 parts of trehalose and 25 parts of composite hydroxyapatite are further added to the mixture C, and the mixture is stirred under vacuum conditions for 30 minutes to obtain an effective material containing composite hydroxyapatite for alleviating dry mouth and bad breath in middle-aged and elderly people.

[0028] Example 2 Preparation of composite hydroxyapatite: S1. Preparation of hydroxyapatite: S1.1, dissolving calcium nitrate tetrahydrate in water to prepare a calcium-containing solution with a mass fraction of 13%, and adjusting the pH value of the solution to 9 with a 1 mol / L sodium hydroxide aqueous solution to obtain a solution A; S1.2, add ammonium dihydrogen phosphate to solution A, heat to 50°C, and stir for 40 minutes to obtain solution B, wherein the weight ratio of ammonium dihydrogen phosphate in solution B to solution A is 4:95; S1.3, pouring solution B into a reaction kettle, stirring at 130°C for 22 hours, washing the obtained substance with deionized water and anhydrous ethanol, and drying in a constant temperature drying oven at 60°C for 10 hours to obtain hydroxyapatite; S2. Preparation of modified hydroxyapatite: Mix menthol: clove oil: anhydrous ethanol in a volume ratio of 18:5:50 to obtain a mixed solution, add hydroxyapatite, wherein the weight volume ratio of hydroxyapatite to the mixed solution is 1:19 g / mL, stir at 60°C for 11 hours, then rotary evaporate for 1.5 hours, wash with deionized water, and then dry at 70°C for 9 hours to obtain modified hydroxyapatite; S3. Preparation of composite hydroxyapatite: The modified hydroxyapatite is dispersed in deionized water, and high methoxy pectin is added after ultrasonic treatment for 15 minutes. After stirring at a speed of 200 r / min for 1.5 hours, hydroxyethyl cellulose is added to increase the speed to 350 r / min and continue stirring for 3 hours, and then dried in a vacuum drying oven at 48°C for 12 hours. The obtained solid is ball milled at a speed of 400 r / min for 3 hours and then passed through a 200-mesh sieve to obtain the composite hydroxyapatite, wherein the mass ratio of the modified hydroxyapatite, hydroxyethyl cellulose, high methoxy pectin and deionized water is 20:5:3:100.

[0029] Preparation of a functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the elderly: By weight, 13 parts of deionized water, 0.2 parts of sodium saccharin, and 2.5 parts of sodium lauroyl sarcosinate are fully mixed and stirred to dissolve to obtain a mixture A, and then 4 parts of glycerol, 33 parts of sorbitol, and 0.8 parts of cellulose gum are added, and the mixture is stirred at a speed of 250 r / min for 80 minutes to obtain a mixture B; after the mixture A and the mixture B are mixed, 0.15 parts of superoxide dismutase and 0.15 parts of glucanase are added, and the mixture is stirred at a speed of 350 r / min for 80 minutes to obtain a mixture C; 4 parts of trehalose and 30 parts of composite hydroxyapatite are further added to the mixture C, and the mixture is stirred under vacuum conditions for 50 minutes to obtain the functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly.

[0030] Example 3 Preparation of composite hydroxyapatite: S1. Preparation of hydroxyapatite: S1.1. Dissolve calcium nitrate tetrahydrate in water to prepare a calcium solution with a mass fraction of 15%, and adjust the pH value of the solution to 10 with a 1 mol / L sodium hydroxide aqueous solution to obtain a solution A; S1.2, add ammonium dihydrogen phosphate to solution A, heat to 60°C, and stir for 60 minutes to obtain solution B, wherein the weight ratio of ammonium dihydrogen phosphate in solution B to solution A is 5:100; S1.3, pouring solution B into a reaction kettle, stirring at 150°C for 25 hours, washing the obtained substance with deionized water and anhydrous ethanol, and drying in a constant temperature drying oven at 70°C for 12 hours to obtain hydroxyapatite; S2. Preparation of modified hydroxyapatite: Mix menthol: clove oil: anhydrous ethanol in a volume ratio of 20:6:55 to obtain a mixed solution, add hydroxyapatite, wherein the weight volume ratio of hydroxyapatite to the mixed solution is 1:20 g / mL, stir at 65°C for 12 hours, then rotary evaporate for 2 hours, wash with deionized water, and then dry at 75°C for 10 hours to obtain modified hydroxyapatite; S3. Preparation of composite hydroxyapatite: The modified hydroxyapatite is dispersed in deionized water, ultrasonically treated for 15 minutes, and then high methoxy pectin is added. After stirring at a speed of 200 r / min for 2 hours, hydroxyethyl cellulose is added and the speed is increased to 400 r / min and stirring is continued for 4 hours. Then, the mixture is dried in a vacuum drying oven at 50°C for 14 hours. The obtained solid is ball milled at a speed of 400 r / min for 3 hours and then passed through a 200-mesh sieve to obtain the composite hydroxyapatite, wherein the mass ratio of the modified hydroxyapatite, hydroxyethyl cellulose, high methoxy pectin and deionized water is 25:6:5:100.

[0031] Preparation of a functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the elderly: By weight, 15 parts of deionized water, 0.3 parts of sodium saccharin and 3 parts of sodium lauroyl sarcosinate are fully mixed and stirred to dissolve to obtain a mixture A, and then 5 parts of glycerol, 35 parts of sorbitol and 1 part of cellulose gum are added, and the mixture is stirred at a speed of 250 r / min for 100 minutes to obtain a mixture B; after the mixture A and the mixture B are mixed, 0.2 parts of superoxide dismutase and 0.2 parts of glucanase are added, and the mixture is stirred at a speed of 350 r / min for 90 minutes to obtain a mixture C; 5 parts of trehalose and 35 parts of composite hydroxyapatite are further added to the mixture C, and the mixture is stirred under vacuum conditions for 60 minutes to obtain the functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly.

[0032] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that the composite hydroxyapatite in Comparative Example 1 is not processed by step S2 during the preparation process, and the other operations are the same.

[0033] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that high methoxy pectin is not added during the preparation of the composite hydroxyapatite in Comparative Example 2, and the other operations are the same.

[0034] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that the composite hydroxyapatite in Comparative Example 3 is not processed by step S3 during the preparation process, and the other operations are the same.

[0035] Comparative Example 4 The difference between Comparative Example 4 and Example 1 is that the hydroxyapatite in Comparative Example 4 is not processed by steps S2 and S3, and the other operations are the same.

[0036] Performance Test: The functional material containing composite hydroxyapatite prepared by the present invention for alleviating dry mouth and bad breath of middle-aged and elderly people can be directly used as toothpaste.

[0037] 1. Bad breath test: A total of 140 males and females aged 50 to 67 years with halitosis were selected as research subjects. According to the breath value, gender and age before the test, the subjects were randomly and evenly divided into 7 groups, with 20 people in each group.

[0038] Testing requirements and judgment methods: The subjects squeeze the toothpaste prepared in Examples 1 to 3 and the toothpaste prepared in Comparative Examples 1 to 4 onto the toothbrush and ensure 2 minutes of brushing time. Use the Halimeter breath detector, which uses the principle of electrochemistry to express the concentration of volatile sulfides in oral gas in the form of a numerical value, which can be used as an indicator to measure the patient's breath level. Test the average breath value of 20 people in each group 5 minutes after brushing their teeth; the average breath value 30 minutes after brushing their teeth; the average breath value 60 minutes after brushing their teeth; the average breath value 120 minutes after brushing their teeth. The difference between the average breath value of each group before brushing their teeth and the average breath value 5 minutes, 30 minutes, 60 minutes, and 120 minutes after brushing their teeth is used to calculate the breath reduction rate to judge the effect of removing bad breath. The results are shown in Table 1 below; Breath odor reduction rate (%) = difference in average breath odor values / average breath odor value before brushing; Table 1

[0039] According to the above data, the bad breath reduction rates in each time period in Examples 1-3 are significantly higher than those in Comparative Examples 1-4, indicating that the functional materials prepared in the examples play an important role in removing bad breath.

[0040] 2. Dry mouth test: Experimental methods: A total of 70 patients with xerostomia were recruited. The inclusion and exclusion criteria were that the Western medical diagnosis was consistent with the 2002 SS international classification standard (AECG standard), and the case exclusion criteria were based on the "Guidelines for Clinical Research on New Chinese Medicines for the Treatment of Sjögren's Syndrome". The age ranged from 50 to 75 years old, with no other systemic diseases, normal swallowing function, and no history of oral ulcers and salivary gland diseases.

[0041] 70 patients were randomly divided into 7 groups (Examples 1-3 and Comparative Examples 1-4, 10 patients in each group), and brushed their teeth twice a day with the test samples in the morning and evening for 3 minutes each time, and maintained a daily water intake of 1500 mL for 28 days, and the changes in the degree of dry mouth in the two groups of patients were observed.

[0042] The visual analysis scale (VAS) scoring method was used to observe the dry mouth condition of the subjects. The patients recorded and scored their dry mouth, oral comfort, speaking ability, chewing and swallowing ability, sleep and other issues on a 100 mm long visual analysis scale (VAS) according to their subjective feelings. One end of the scale marked negative symptoms, such as very dry, very uncomfortable or very difficult, with 100 points; the other end of the scale marked positive symptoms, such as not dry, comfortable or fluent, with 0 points.

[0043] The position was marked on the ruler according to the degree of the symptom. Both groups used this scoring method to record before using the toothpaste. After using the test toothpaste for 28 days, this scoring method was used again to record the subject's score. After the subjects used the test toothpaste for 28 days, the VAS scoring results of dry mouth are shown in Table 2 below: Table 2

[0044] According to the above data, after the subjects with dry mouth used Examples 1-3 of the present invention, the dry mouth degree of the subjects was alleviated, and the oral comfort was also improved to a certain extent. At the same time, the VAS score of dry mouth in Comparative Examples 1-4 was significantly higher than that in Examples 1-3, and P < 0.05. This shows that the functional material prepared by the present invention has the effect of alleviating dry mouth and bad breath in the middle-aged and elderly.

[0045] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the elderly, characterized in that: The invention comprises the following raw materials in parts by weight: 10-15 parts of deionized water, 0.1-0.3 parts of sweetener, 2-3 parts of surfactant, 3-5 parts of glycerol, 30-35 parts of humectant, 0.6-1 parts of thickener, 3-5 parts of trehalose, 25-35 parts of composite hydroxyapatite, 0.1-0.2 parts of superoxide dismutase and 0.1-0.2 parts of glucanase; The preparation process of the composite hydroxyapatite is as follows: S1. Preparation of hydroxyapatite: S1.

1. Dissolve calcium salt in water to prepare a calcium solution with a mass fraction of 10-15%, and adjust the pH value of the solution to 8-10 with alkali to obtain solution A; S1.2, add ammonium dihydrogen phosphate to solution A, heat to 40-60°C, and stir for 30-60 min to obtain solution B, wherein the weight ratio of ammonium dihydrogen phosphate in solution B to solution A is (3-5): (90-100); S1.3, pour solution B into the reactor, stir at 120-150°C for 18-25h, wash the obtained substance with deionized water and anhydrous ethanol, dry it in a constant temperature drying oven at 55-70°C for 8-12h, grind the dried solid with a ball mill at a speed of 400r / min for 3h, and then pass it through a 200-mesh sieve to obtain hydroxyapatite; S2. Preparation of modified hydroxyapatite: Mix menthol: clove oil: anhydrous ethanol in a volume ratio of (15-20): (4-6): (45-55) to obtain a mixed solution, add hydroxyapatite, stir at 55-65°C for 10-12 hours, perform rotary evaporation for 1-2 hours, wash with deionized water, and dry at 65-75°C for 8-10 hours to obtain modified hydroxyapatite; S3. Preparation of composite hydroxyapatite: The modified hydroxyapatite is dispersed in deionized water, ultrasonically treated for 15 minutes, and then high methoxy pectin is added. After stirring at a speed of 200 r / min for 1-2 hours, hydroxyethyl cellulose is added and the speed is increased to 300-400 r / min and stirring is continued for 2-4 hours. The mixture is dried in a vacuum drying oven at 45-50° C. for 10-14 hours. The obtained solid is ball-milled in a ball mill and then sieved through a 200-mesh sieve to obtain the composite hydroxyapatite, wherein the mass ratio of the modified hydroxyapatite, hydroxyethyl cellulose, high methoxy pectin and deionized water is (15-25):(3-6):(2-5):

100.

2. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that: The thickener is one of polyvinyl pyrrolidone, xanthan gum and cellulose gum.

3. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that: The moisturizing agent is one or both of sorbitol and polyethylene glycol-8.

4. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that: The surfactant is one of sodium lauroyl sarcosinate and lauryl alcohol.

5. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that: The sweetener is one of saccharin sodium and stevia extract.

6. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the elderly according to claim 1, characterized in that: In step S1.1, the calcium salt is one of calcium nitrate tetrahydrate and calcium chloride.

7. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that: In step S1.1, the alkali is a sodium hydroxide aqueous solution with a concentration of 1 mol / L.

8. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that: In step S2, the weight volume ratio of the hydroxyapatite to the mixed solution is 1: (18-20) g / mL.

9. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that: In step S3, the ball milling condition is grinding at a rotation speed of 400 r / min for 3 hours.

10. A method for preparing a functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the elderly as claimed in any one of claims 1 to 9, characterized in that: The preparation process includes the following: The sweetener, surfactant and deionized water are fully mixed by weight, stirred and dissolved to obtain a mixture A, and then a humectant, glycerin and a thickener are added, and the mixture is stirred at a speed of 250 r / min for 70 to 100 minutes to obtain a mixture B; after the mixture A and the mixture B are mixed, superoxide dismutase and glucanase are added, and the mixture is stirred at a speed of 350 r / min for 60 to 90 minutes to obtain a mixture C; the composite hydroxyapatite and trehalose are continuously added to the mixture C, and the mixture is stirred under vacuum conditions for 30 to 60 minutes to obtain the functional material containing the composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly.

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