Blood analyzer and blood analysis method

Abstract

The invention discloses a blood analyzer and a blood analysis method.According to the blood analyzer, whether first detection data obtained through detection is within a preset interval or not is judged through a control unit, so that a to-be-detected sample is redetected when the first detection data is larger than a first endpoint value, and interference factors possibly influencing platelet detection accuracy are eliminated; when the first detection data is smaller than the second endpoint value, the platelet detection result is output, the processing time can be shortened, and the platelet detection efficiency is improved; in addition, the blood analyzer judges whether the detection unit comprises a second detection unit or not by acquiring the detection unit carried by the blood analyzer, so that a corresponding processing method is automatically selected according to the configuration of the blood analyzer to perform reinspection on the to-be-detected sample, and the accuracy of the blood analyzer is improved. The blood analyzer can automatically process the to-be-detected sample with abnormal platelet detection, so that the manual intervention and processing time is effectively shortened, the cost is reduced, and the platelet detection efficiency is improved.

Description

Technical Field

[0001] The present application relates to the technical field of blood analysis, and in particular to a blood analyzer and a blood analysis method. Background Art

[0002] Platelets are small pieces of cytoplasm that fall off from the cytoplasm of mature megakaryocytes in the bone marrow. They are blood components that participate in human coagulation and hemostasis. Existing blood analyzers usually use the impedance method to measure the number and size of red blood cells and platelets when performing platelet count detection (PLATELET, PLT). The impedance method determines the volume of the detection particles by obtaining the pulse amplitude of the sample flow through the detection hole, so as to distinguish platelets according to the volume difference of blood cells. In the PLT detection process, it is easy to be affected by platelet aggregation, large platelets, red blood cell fragments, small red blood cells, cold globulins, etc., resulting in a false decrease or increase in PLT count data, and then making an erroneous report on the PLT count. When the PLT count is abnormal, it is necessary to manually eliminate the interference factors, which has high labor costs and low accuracy of the blood analyzer. Summary of the invention

[0003] To solve the above technical problems, the present application provides a blood analyzer and a blood analysis method.

[0004] To solve the above problems, the present application provides a blood analyzer, including a first detection unit and a control unit. The first detection unit is used to perform impedance detection or optical detection on a sample to be tested to obtain first detection data of platelets of the sample to be tested; the control unit is connected to the first detection unit, and is used to determine whether the first detection data is within a preset interval, the preset interval includes a first endpoint value and a second endpoint value, and the first endpoint value is greater than the second endpoint value; wherein the control unit is used to generate a platelet detection result of the sample to be tested according to the first detection data in response to the first detection data being less than the second endpoint value; the control unit is also used to control the blood analyzer to re-test the sample to be tested in response to the first detection data being greater than the first endpoint value, so as to obtain the second detection data of the sample to be tested, and the control unit is also used to generate the platelet detection result of the sample to be tested according to the second detection data; or, the control unit is used to obtain a detection unit carried by the blood analyzer, and the control unit is also used to control the second detection unit to re-test the sample to be tested in response to the detection unit including the second detection unit and the first detection data not being within the preset interval, so as to obtain the third detection data, and generate the platelet detection result of the sample to be tested according to the third detection data, and the detection channel of the second detection unit is different from the detection channel of the first detection unit.

[0005] Optionally, the blood analyzer also includes an incubation unit, which is connected to the control unit. The control unit is used to control the incubation unit to incubate the sample to be tested at a preset temperature in response to the first detection data being greater than the first endpoint value, so that the blood analyzer re-tests the sample to be tested after incubation.

[0006] Optionally, the second detection unit is connected to the control unit, and the second detection unit is used to perform reticulocyte detection or platelet detection on the sample to be tested; the first detection unit is used to perform impedance detection on the sample to be tested and obtain first detection data, and the control unit is used to control the second detection unit to perform reticulocyte detection or platelet detection on the sample to be tested in response to the first detection data being greater than the first endpoint value, so as to obtain second detection data; the first detection unit is used to perform reticulocyte detection on the sample to be tested and obtain first detection data, and the control unit is used to control the second detection unit to perform platelet detection on the sample to be tested in response to the first detection data being greater than the first endpoint value, so as to obtain second detection data.

[0007] Optionally, the first detection data includes platelet count data, volume data and distribution density data of the sample to be tested, and the control unit is used to generate a first prompt information when the count data is less than the second endpoint value, and the volume data and / or the distribution density data is greater than a first preset value, and the first prompt information is used to indicate that the sample to be tested has the possibility of platelet aggregation; the control unit is used to generate a second prompt information when the count data is less than the second endpoint value, and the volume data and / or the distribution density data is less than or equal to the first preset value, and the second prompt information is used to indicate that the sample to be tested has the possibility of large volume platelets or abnormally low platelets.

[0008] Optionally, the control unit is used to generate a third prompt message in response to the second test data being greater than the first endpoint value, and / or the control unit is used to generate a third prompt message in response to the difference between the second test data and the first test data being less than a second preset value, the third prompt message being used to indicate the possibility that the sample to be tested has at least one of red blood cell fragments, microerythrocytes, and abnormally high platelets; the control unit is used to generate a fourth prompt message in response to the second test data being less than the first endpoint value, and / or the control unit is used to generate a fourth prompt message in response to the difference between the second test data and the first test data being greater than or equal to the second preset value, the fourth prompt message being used to indicate the possibility that the sample to be tested has the influence of cryoglobulins.

[0009] Optionally, the blood analyzer further comprises a sample preparation unit, which is used for adding a disaggregation reagent to the sample to be tested to disaggregate the platelets in the sample to be tested, and the second detection unit is used for retesting the disaggregated sample to be tested.

[0010] Optionally, the second detection unit is used to perform reticulocyte detection, and the control unit is used to generate fifth prompt information in response to the third detection data being greater than the first endpoint value, the fifth prompt information being used to indicate the possibility that the sample to be tested has abnormally high platelets, and the control unit is used to generate sixth prompt information in response to the third detection data being less than the second endpoint value, the sixth prompt information being used to indicate the possibility that the sample to be tested has at least one of platelet aggregation, large platelets, and abnormally low platelets.

[0011] Optionally, the second detection unit is used to perform platelet detection, and the control unit is used to generate fifth prompt information in response to the third detection data being greater than the first endpoint value, the fifth prompt information being used to indicate the possibility that the sample to be tested has abnormally high platelets, and the control unit is used to generate seventh prompt information in response to the third detection data being less than the second endpoint value, the seventh prompt information being used to indicate the possibility that the sample to be tested has platelet aggregation or abnormally low platelets.

[0012] Optionally, the control unit is also used to obtain scattered point data of the third detection unit; the control unit is also used to judge whether the sample to be tested has the possibility of platelet aggregation according to the scattered point data in response to the third detection data being less than the second endpoint value, so as to generate a platelet detection result according to the judgment result.

[0013] To solve the above problems, the present application provides a blood analysis method, including: controlling a first detection unit to perform impedance detection or optical detection on a sample to be tested to obtain first detection data of platelets in the sample to be tested; in response to the first detection data being greater than a first endpoint value, controlling a blood analyzer to re-test the sample to be tested to obtain second detection data of the sample to be tested, and generating a platelet detection result of the sample to be tested based on the second detection data; in response to the first detection data being less than a second endpoint value, generating a platelet detection result of the sample to be tested based on the first detection data, wherein the first endpoint value is greater than the second endpoint value; or, controlling the first detection unit to perform impedance detection or optical detection on the sample to be tested to obtain first detection data; obtaining a detection unit carried by a blood analyzer; in response to the detection unit including a second detection unit and the first detection data being not within a preset interval, controlling the second detection unit to re-test the sample to be tested to obtain third detection data, wherein the detection channel of the second detection unit is different from the detection channel of the first detection unit.

[0014] Different from the prior art, the blood analyzer provided by the present application determines whether the first test data obtained by the detection is within a preset interval through a control unit, so as to re-examine the sample to be tested when the first test data is greater than the first endpoint value, so as to eliminate the interference factors that may affect the accuracy of platelet detection, and output the platelet detection result when the first test data is less than the second endpoint value, which can reduce the processing time and improve the efficiency of platelet detection; the blood analyzer of the present application also obtains the detection unit carried by the blood analyzer, determines whether the detection unit includes the second detection unit, and automatically selects the corresponding processing method according to the configuration of the blood analyzer to re-examine the sample to be tested, so as to improve the accuracy of the blood analyzer. The blood analyzer of the present application can automatically process the sample to be tested with abnormal platelet detection, effectively reducing the time of manual intervention and processing, reducing costs, and improving the efficiency of platelet detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0016] in:

[0017] Figure 1 It is a structural schematic diagram of an embodiment of a blood analyzer provided by the present application;

[0018] Figure 2 is a structural schematic diagram of another embodiment of the blood analyzer provided by the present application;

[0019] Figure 3 It is a schematic diagram of the detection process of the first embodiment of the blood analyzer provided by the present application;

[0020] Figure 4 is a schematic diagram of the detection process of the second embodiment of the blood analyzer provided by the present application;

[0021] Figure 5 is a schematic diagram of the detection process of the third embodiment of the blood analyzer provided by the present application;

[0022] Figure 6 is a schematic diagram of the detection process of the fourth embodiment of the blood analyzer provided by the present application;

[0023] Figure 7 is a schematic diagram of the detection process of the fifth embodiment of the blood analyzer provided by the present application;

[0024] Figure 8It is a flow chart of an embodiment of the blood analysis method provided by the present application;

[0025] Fig. 9 is a flow chart of another embodiment of the blood analysis method provided by the present application;

[0026] Fig.10 It is a structural schematic diagram of an embodiment of a computer-readable storage medium provided by the present application. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0029] It should be noted that if the embodiments of the present application involve directional indications (such as up, down, left, right, front, back...), the directional indications are only used to explain the relative position relationship, movement status, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

[0030] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the present application, the descriptions of "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or suggesting their relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such combination of technical solutions does not exist and is not within the scope of protection required by this application.

[0031] See also Figure 1 , Figure 1 FIG. 1 is a schematic diagram of the structure of an embodiment of a blood analyzer provided by the present application. Figure 1 As shown, the blood analyzer provided in this embodiment includes a first detection unit and a control unit.

[0032] The first detection unit is used to perform impedance detection or optical detection on the sample to be tested to obtain first detection data of platelets in the sample to be tested; the control unit is connected to the first detection unit, and is used to determine whether the first detection data is within a preset interval, the preset interval includes a first endpoint value and a second endpoint value, and the first endpoint value is greater than the second endpoint value.

[0033] Specifically, in an optional embodiment, the first detection unit measures the cell volume of red blood cells and platelets of the sample to be tested by a direct current impedance (DC) method, so as to segment the platelets and red blood cells according to the histogram of the acquired electrical signal, so as to obtain the detection data of the platelets and red blood cells. Since the impedance method distinguishes platelets according to the volume difference of blood cells, when there is an abnormality in the histogram, such as when the red blood cell volume is close to the platelet volume, such as when the platelet tail of the histogram is too high, the platelet count will be disturbed, resulting in abnormal platelet detection data, and the interference factors may include small red blood cells, cell fragments, microplatelets, giant platelets, platelet aggregation, cold globulin effects, etc.

[0034] In another optional embodiment, the first detection unit can also perform multi-dimensional analysis of the sample to be tested by nucleic acid fluorescence staining and laser scattering. For example, the first detection unit can be to detect the sample to be tested under the reticulocyte detection channel, and the first detection unit removes interference factors such as small red blood cells and cell fragments in the platelet count by synchronously staining platelets during nucleic acid staining of reticulocytes. It can be understood that the first detection unit of this embodiment is the result of the initial platelet test of the sample to be tested by default in the blood analyzer. For example, when the blood analyzer includes a first detection channel (PLT-I) for detection by electrical impedance method and / or a second detection channel (PLT-O) for reticulocyte detection by nucleic acid fluorescence staining and laser scattering method, the user sets the blood analyzer to select PLT-I or PLT-O to detect the sample to be tested, so that the first detection unit detects the sample to be tested through PLT-I or PLT-O, and the detection methodology of the first detection unit is not specifically limited here.

[0035] The control unit may include a memory and a processor. The memory is used to store all information in the blood analyzer, including the raw data input by the blood analyzer, computer programs, intermediate operation results and final operation results are all stored in the memory. The processor may be an electronic chip with signal processing capabilities. The memory stores and retrieves information according to the position specified by the processor so that the processor can perform corresponding operations. The control unit is connected to the first detection unit and is used to obtain the first detection data of the first detection unit for detecting the sample to be tested. The first detection data includes platelet counting data and may also include at least one of volume data and distribution density data, so that the control unit can determine whether it is within a preset interval based on the first detection data. The preset interval can be the normal detection range of platelets preset by the blood analyzer. For example, the normal detection range of platelet count (PLT) in human blood is (100~300)×10 9The preset interval may also be an interval that is adjusted upward based on the normal detection range. For example, the normal detection range is [100, 300], and the preset interval may be [50, 350]. The processor retrieves the preset interval stored in the memory to determine whether the first detection data is within the preset interval.

[0036] Among them, the control unit is used to generate a platelet test result of the sample to be tested according to the first test data in response to the first test data being less than the second endpoint value; the control unit is also used to control the blood analyzer to re-test the sample to be tested in response to the first test data being greater than the first endpoint value to obtain the second test data of the sample to be tested, and the control unit is also used to generate a platelet test result of the sample to be tested according to the second test data.

[0037] When the first test data is less than the second endpoint value, that is, the platelet test data of the sample to be tested exceeds the lower limit of the preset interval, at this time, the possibility of platelet test abnormality can be analyzed based on the first test data to generate a platelet test result. The platelet test result can be presented in the form of a report. For example, the platelet test result can include the first test data, abnormal analysis, and interference factors of platelet test abnormality, etc., so as to reduce the steps of manual analysis and processing, improve the efficiency of platelet testing, and reduce labor costs.

[0038] When the first test data is greater than the first endpoint value, that is, the platelet test data of the sample to be tested exceeds the upper limit of the preset interval, at this time, the control unit can control the blood analyzer to re-test the sample to be tested with abnormal test data to eliminate interference factors that may affect the accuracy of platelet detection. In an optional implementation, the control unit can perform abnormal processing on the sample to be tested with abnormal test data according to the functional configuration supported by the blood analyzer, and then control the blood analyzer to re-test the processed sample to be tested. The abnormal processing includes incubation processing, deaggregation reagent processing and other processing methods; when the blood analyzer supports a more accurate platelet detection method, the control unit can also control the selection of other detection channels to re-test the sample to be tested to further eliminate interference factors in platelet detection and improve the accuracy of platelet detection.

[0039] In an embodiment of the present application, when the blood analyzer performs platelet detection on the sample to be tested, the control unit determines whether the first test data obtained by the detection is within a preset interval, and re-tests the sample to be tested when the first test data is greater than the first endpoint value, so as to eliminate interference factors that may affect the accuracy of the platelet detection, and outputs the platelet detection result when the first test data is less than the second endpoint value, which can reduce processing time and improve the efficiency of platelet detection. Since the sample to be tested with abnormal detection is automatically processed, the time for manual intervention and processing can be effectively reduced, the cost can be reduced, and the accuracy of the blood analyzer can be improved.

[0040] Alternatively, if Figure 1 As shown, the blood analyzer includes an incubation unit, which is connected to a control unit. The control unit is used to control the incubation unit to incubate the sample to be tested at a preset temperature in response to the first detection data being greater than the first endpoint value, so that the blood analyzer re-tests the sample to be tested after incubation.

[0041] Specifically, the blood analyzer includes an incubation unit, which is used to perform a constant temperature incubation on the sample to be tested, so that the sample to be tested is incubated at a preset temperature for a preset time. When the first detection unit uses the electrical impedance method to detect platelets and red blood cells, the platelet counting process is easily affected by globulin, so that the platelet detection data is abnormally high. Therefore, in response to the first detection data being greater than the first endpoint value, the control unit controls the incubation unit to perform an incubation treatment on the sample to be tested, and the incubation treatment is used to simulate body temperature so that part of the cryoglobulin precipitated in a low temperature environment is dissolved.

[0042] Among them, when there are cryoglobulins in the blood that can undergo reversible cold precipitation, the cryoglobulins generally precipitate in a low-temperature environment and dissolve at a preset temperature (for example, 37°). When the first test data is greater than the first endpoint value, the sample to be tested may be affected by interfering factors such as red blood cell fragments, microerythrocytes, and cryoglobulins. Therefore, the control unit incubates the sample to be tested in response to the first test data being greater than the first endpoint value, so that the first detection unit can eliminate the interference of cryoglobulins or determine the influence of cryoglobulins based on the second test data of the re-test after re-testing the sample to be tested, so that the blood analyzer can automatically process when the platelet test data is high, thereby reducing the time for manual intervention and processing, reducing costs, and improving the accuracy of the blood analyzer.

[0043] In an optional embodiment, when the incubation unit performs incubation treatment, the preset temperature can be set in the range of 35 to 43°C, for example, the preset temperature can be 35°C, 36°C, 37°C, 38°C, 39°C, 40°C, 41°C, 42°C or 43°C; the preset time can be set in the range of 20-60 minutes, for example, the preset time can be 20, 30, 40, 50 or 60 minutes. The control unit can set the preset temperature and preset time according to the difference between the first test data and the first endpoint value. For example, the control unit can control the incubation unit to perform incubation treatment at 38°C for 40 minutes on the sample to be tested when the difference between the first test data and the first endpoint value is large (which may indicate a high degree of agglutination). No specific limitation is made here.

[0044] Optionally, the first detection data includes the platelet count data, volume data and distribution density data of the sample to be tested, and the control unit is used to generate a first prompt information when the count data is less than the second endpoint value, and the volume data and / or the distribution density data is greater than a first preset value, and the first prompt information is used to indicate the possibility that the sample to be tested has platelet aggregation. The control unit is also used to generate a second prompt information when the count data is less than the second endpoint value, and the volume data and / or the distribution density data is less than or equal to the first preset value, and the second prompt information is used to indicate the possibility that the sample to be tested has a large volume of platelets or an abnormally low platelet count.

[0045] Specifically, the first test data includes platelet count data (PLT), volume data and distribution density data, the volume data is the mean platelet volume (MPV) of the sample to be tested, and the distribution density data is the platelet distribution density (PDW) of the sample to be tested. The control unit is used to determine whether the count data is within a preset interval, and in response to the count data being less than the second endpoint value and the volume data and / or distribution density data being less than or equal to the first preset value, determine that the volume and distribution density data of the platelets are within the normal range. At this time, it may be that a large number of large platelets appear, so that the large platelets are classified as red blood cells by the first detection unit, resulting in low platelet count data, or it may be that the platelet count data is low due to the small number of platelets in the sample to be tested itself, and the control unit generates a second prompt information, the second prompt information is used to indicate the possibility that the sample to be tested has large platelets or abnormally low platelets, and generates a platelet test result according to the second prompt information.

[0046] The control unit is also used to respond to the count data being less than the second endpoint value and the volume data and / or distribution density data being greater than the first preset value, determine that the volume and distribution density data of the platelets are beyond the normal detection range. At this time, the platelet count data may be low due to platelet aggregation, and the control unit generates a first prompt information, the first prompt information is used to indicate the possibility of platelet aggregation in the sample to be tested, and generates a platelet detection result according to the first prompt information. The first preset value is the upper limit of the normal range of the set MPV and / or PDW.

[0047] In an embodiment of the present application, when the count data of the first test data is low, the control unit automatically eliminates interference factors that may affect the accuracy of platelet detection by determining whether the volume data and / or distribution density data of the sample to be tested is greater than a first preset value. There is no need to manually process and judge the abnormalities of the sample to be tested, thereby reducing the time for manual intervention and processing, and improving the accuracy of the platelet detection results.

[0048] Optionally, see Figure 2 , Figure 2 FIG. 1 is a schematic diagram of the structure of another embodiment of the blood analyzer provided by the present application. Figure 2 As shown, the blood analyzer of this embodiment also includes a second detection unit, which is used to perform optical detection on the sample to be tested, and the detection channel of the second detection unit is different from the detection channel of the first detection unit. The first detection data includes platelet counting data, volume data and distribution density data of the sample to be tested.

[0049] Specifically, the second detection unit is used to perform multi-dimensional analysis on the sample to be tested by nucleic acid fluorescence staining and laser scattering. The second detection unit performs fluorescent staining on the sample to be tested by nucleic acid fluorescence staining to distinguish stained cells from other cells according to the fluorescence intensity of the sample particles of the sample to be tested, and performs multi-dimensional analysis on the sample particles by laser scattering to obtain the laser signal and fluorescence signal of the sample to be tested, and generates second detection data according to the laser signal and the fluorescence signal. Among them, the second detection unit of this embodiment is used to limit the detection unit for re-examination of the sample to be tested. According to the different nucleic acid staining areas of the second detection unit and the detection channels used, the second detection unit can be used for reticulocyte detection or platelet detection.

[0050] Exemplarily, the blood analyzer includes a first detection channel (PLT-I) and a second detection channel (PLT-O) that detect by electrical impedance method, PLT-O stains reticulocytes and platelets by nucleic acid fluorescence staining and analyzes the sample to be tested by laser scattering method. At this time, the first detection unit can detect the sample to be tested through the first detection channel (PLT-I), and the second detection unit can re-test the sample to be tested through the second detection channel (PLT-O); when the blood analyzer also includes a third detection channel (PLT-F), PLT-F uses nucleic acid fluorescence staining to stain reticulocytes and platelets and analyzes the sample to be tested by laser scattering method. The fluorescent staining method is used to specifically stain platelets and the laser scattering method is used to analyze the sample to be tested. At this time, the first detection unit can detect the sample to be tested through the first detection channel (PLT-I) or the second detection channel (PLT-O), and the second detection unit can re-test the sample to be tested through the third detection channel (PLT-F). Alternatively, the first detection unit can detect the sample to be tested through the first detection channel (PLT-I), and the second detection unit can re-test the sample to be tested through the second detection channel (PLT-O) or the third detection channel (PLT-F).

[0051] The control unit is used to determine whether the volume data and / or distribution density data is greater than a first preset value in response to the counting data being less than a second endpoint value, so as to generate a platelet detection result of the sample to be tested based on the judgment result; the control unit is also used to control the second detection unit to re-test the sample to be tested in response to the counting data being greater than the first endpoint value, so as to obtain second detection data.

[0052] For further information, see Figure 3 , Figure 3 Schematic diagram of the detection process of the first embodiment of the blood analyzer provided by the present application. Figure 3 As shown, when the count data of the first detection data is low, the control unit determines whether the platelets have the possibility of agglutination by determining whether the volume data and / or distribution density data of the sample to be tested is greater than a first preset value. When the count data of the first detection data is high, the control unit also controls the second detection unit to re-examine the sample to be tested to exclude the possibility that the sample to be tested contains small red blood cells, red blood cell fragments, and cryoglobulins. The judgment method of the volume data and / or distribution density data is similar to that of the above embodiment, so that corresponding prompt information is generated according to different judgment results. It can be understood that since the second detection unit divides red blood cells and platelets by fluorescent staining, the fluorescence intensity of small red blood cells, red blood cell fragments, and cryoglobulins during the detection process is generally low, so that the interference factors of small red blood cells, red blood cell fragments, and cryoglobulins can be excluded when re-examining by the second detection unit.

[0053] In an embodiment of the present application, when the counting data is greater than the first endpoint value (too high), the control unit controls the second detection unit with a different detection channel to re-test the sample to be tested, so as to eliminate interference factors that may affect the accuracy of platelet detection through a more accurate testing method. There is no need to manually process and judge the abnormalities of the sample to be tested, thereby reducing the time for manual intervention and processing, and improving the accuracy of the platelet detection results.

[0054] Optionally, see Figure 4 , Figure 4 1 is a schematic diagram of the detection process of the second embodiment of the blood analyzer provided by the present application. Figure 4As shown, the first detection unit detects the sample to be tested through the first detection channel (PLT-I) to obtain the first detection data, when the first detection data is high, the sample to be tested is incubated and retested through the first detection channel (PLT-I) to obtain the second detection data, the control unit is used to respond to the second detection data being greater than the first endpoint value, and / or, the control unit is used to respond to the difference between the second detection data and the first detection data being less than the second preset value, generate a third prompt information, the third prompt information is used to indicate the possibility that the sample to be tested has at least one of red blood cell fragments, microerythrocytes and abnormally high platelets. The control unit is used to respond to the second detection data being less than the first endpoint value, and / or, the control unit is used to respond to the difference between the second detection data and the first detection data being greater than or equal to the second preset value, generate a fourth prompt information, the fourth prompt information is used to indicate the possibility that the sample to be tested has the influence of cold globulins.

[0055] After the control unit controls the incubation unit to perform an incubation treatment on the sample to be tested at a preset temperature, the control unit controls the first detection unit to re-examine the sample to be tested after the incubation treatment, and analyzes the influence of the incubation treatment on the sample to be tested based on the second detection data obtained from the re-examination to generate a platelet detection result. In one embodiment, the control unit determines whether the incubation treatment is effective by judging whether the second detection data is greater than the first endpoint value, so as to analyze the possibility that the first detection data of the platelet is too high. In another embodiment, the control unit determines whether the incubation treatment is effective by judging whether the difference between the second detection data and the first detection data is less than a second preset value, so as to analyze the possibility that the first detection data of the platelet is too high. In other embodiments, the control unit determines whether the incubation treatment is effective by judging whether the second detection data is greater than the first endpoint value and whether the difference between the second detection data and the first detection data is less than a second preset value, which is not specifically limited here.

[0056] Specifically, when the second test data is greater than the first endpoint value and / or the difference between the second test data and the first test data is less than the second preset value, it indicates that the second test data obtained by retesting the incubated sample is still too high. At this time, the control unit determines that the incubation treatment is ineffective. The sample to be tested may be affected by small red blood cells or red blood cell fragments, resulting in high platelet test data of platelets, or the platelet test data is high due to a small number of platelets in the sample to be tested itself. The control unit generates a third prompt information, which is used to indicate the possibility that the sample to be tested has at least one of red blood cell fragments, small red blood cells and abnormally high platelets, and generates a platelet test result based on the third prompt information. When the second test data is less than the first endpoint value and / or the difference between the second test data and the first test data is greater than or equal to the second preset value, it indicates that the second test data is low. At this time, the control unit determines that the incubation treatment is effective, and the sample to be tested may be affected by cryoglobulins, resulting in high platelet test data. The control unit generates a fourth prompt information, which is used to indicate the possibility that the sample to be tested is affected by cryoglobulins, and generates a platelet test result based on the fourth prompt information.

[0057] In an embodiment of the present application, the control unit determines the possibility that the sample to be tested is affected by cryoglobulins in response to the second test data being less than the first endpoint value and / or the difference between the second test data and the first test data being greater than or equal to a second preset value, so as to automatically eliminate interference factors that may affect the accuracy of platelet detection. There is no need for manual processing and judgment of abnormalities in the sample to be tested, thereby reducing the time for manual intervention and processing, and improving the accuracy of platelet detection results.

[0058] In one embodiment, if Figure 2 As shown, the control unit is used to obtain the detection unit carried by the blood analyzer, and the control unit is also used to control the second detection unit to re-test the sample to be tested in response to the detection unit including the second detection unit and the first detection data is not within the preset interval to obtain the third detection data, and generate the platelet detection result of the sample to be tested according to the third detection data. Among them, the detection channel of the first detection unit is different from the detection channel of the second detection unit, the detection channel of the first detection unit can be any one of PLT-I and PLT-O, the detection channel of the second detection unit can be any one of PLT-F and PLT-O, the detection channels of the first detection unit and the second detection unit are the same as those in the above embodiment, and will not be repeated here.

[0059] Specifically, in order to meet various detection scenarios, the blood analyzer can be equipped with multiple detection units, for example, the blood analyzer can be equipped with an impedance detection unit for platelet and red blood cell counting, an optical detection unit for reticulocyte (RET) detection, an optical detection unit for platelet (PLT) detection, an optical detection unit for white blood cell (WBC) detection, etc., to support the needs of various detection items. After the control unit obtains the first detection data, it further obtains the detection unit carried by the blood analyzer, and determines whether the detection unit carried by the blood analyzer includes the second detection unit. The above-mentioned second detection unit includes a specific detection channel that can perform platelet detection on the sample to be tested. The detection channel of the second detection unit is related to the detection channel of the first detection unit. Therefore, before the control unit determines whether the detection unit includes the second detection unit, it should also obtain the range of the second detection unit according to the detection channel of the first detection unit. For example, when the detection channel of the first detection unit is PLT-I, the control unit determines whether the second detection unit is included by determining whether the blood analyzer includes PLT-O or PLT-F. When the detection channel of the first detection unit is PLT-O, the control unit determines whether the second detection unit is included by determining whether the blood analyzer includes PLT-F.

[0060] In response to the detection unit including the second detection unit and the first detection data not being within the preset interval, the control unit controls the second detection unit to re-test the sample to be tested to obtain the third detection data, and generates the platelet detection result of the sample to be tested according to the third detection data. Wherein, the first detection data not being within the preset interval may include two situations: the first detection data is greater than the first endpoint value and the first detection data is less than the second endpoint value, which will not be repeated here.

[0061] In response to the detection unit not including the second detection unit and the first detection data not being within the preset interval, the control unit controls the blood analyzer to re-test the sample to be tested or to generate a platelet detection result of the sample to be tested according to the first detection data. Specifically, in one embodiment, the first detection unit is a PLT-I detection channel, and when the detection unit does not include the second detection unit and the first detection data is greater than the first endpoint value, the incubation unit is controlled to incubate the sample to be tested for a preset time, and the first detection unit is controlled to re-test the sample to be tested after the incubation treatment; when the detection unit does not include the second detection unit and the first detection data is less than the second endpoint value, the platelet detection result of the sample to be tested is directly generated according to the first detection data.

[0062] In an embodiment of the present application, the control unit determines whether the detection unit includes a second detection unit by acquiring the detection unit carried by the blood analyzer, so as to automatically select a corresponding processing method to re-examine the test sample according to the configuration of the blood analyzer, thereby reducing the time for manual intervention and processing; when the detection unit includes a second detection unit and the first detection data is not within a preset interval, the control unit controls the second detection unit to re-examine the test sample to exclude the possibility that the test sample contains small red blood cells, red blood cell fragments and cryoglobulins, thereby improving the accuracy of the platelet test results.

[0063] Furthermore, the blood analyzer also includes a sample preparation unit, which is used to add a disaggregation reagent to the sample to be tested to disaggregate the platelets in the sample to be tested, and the second detection unit is used to re-test the disaggregated sample to be tested.

[0064] Specifically, the blood analyzer may include a sampling unit and a sample preparation unit, the sampling unit is used to obtain the sample to be tested in the sample tube from the sample tube received by the blood analyzer, and the sample preparation unit is used to add the detection reagents of different detection units to the sample to be tested to prepare the sample flow required for the detection, so that the detection unit directly performs counting test on the sample flow, and the detection reagent may include diluent, dye solution and other reagents. In an optional embodiment, when the second detection unit performs a re-test through PLT-O or PLT-F, the control unit may also control the sample preparation unit to add a depolymerization reagent to the sample to be tested, so that the sample to be tested reacts with the depolymerization reagent and depolymerizes the aggregated platelets, and the depolymerization reagent may include a common depolymerization component of platelet aggregation, for example, the depolymerization reagent may be a depolymerization component for removing platelet aggregation caused by EDTA dependence (EDTA-PTCP), and the depolymerization component includes but is not limited to heparin.

[0065] Among them, the second detection unit re-examines the sample to be tested after deaggregation to obtain the third detection data. When the third detection data is less than the second endpoint value, that is, the third detection data is low, it may be that the deaggregation component of the deaggregation reagent cannot deaggregate the aggregated platelets, and the control unit generates a prompt information for indicating the possibility that the sample to be tested has platelet aggregation caused by other reasons or the detection data is low due to other reasons. When the third detection data is greater than the first endpoint value, due to the detection principle of the second detection unit, the detection of the sample to be tested excludes the possibility of the influence of small red blood cells, red blood cell fragments, and cold globulins. At this time, the control unit generates a fifth prompt information, and the fifth prompt information is used to indicate the possibility that the sample to be tested has abnormally high platelets. The control unit generates a platelet test result based on the fifth prompt information or the prompt information of the possibility of low test data caused by platelet aggregation or other reasons, so that the user can analyze and process the abnormality of platelet detection by viewing the platelet test result.

[0066] In an embodiment of the present application, before the second detection unit re-tests the sample to be tested, the control unit can add a disaggregation reagent to the sample to be tested through the sample preparation unit, so as to first disaggregate and then test the sample to be tested with abnormal detection. When the third test data is less than the second endpoint value, the blood analyzer can directly rule out the possibility of platelet aggregation caused by some factors, reduce the time for manual intervention and processing, reduce costs, and improve the accuracy of the blood analyzer.

[0067] For further information, see Figure 5 , Figure 5 FIG. 1 is a schematic diagram of the detection process of the third embodiment of the blood analyzer provided by the present application. Figure 5 As shown, in one embodiment, the first detection unit is used to perform impedance detection through PLT-I, the second detection unit is used to perform reticulocyte detection through PLT-O, and the control unit is used to generate a fifth prompt information in response to the third detection data being greater than the first endpoint value, the fifth prompt information being used to indicate the possibility that the sample to be tested has an abnormally high platelet count, and the control unit is also used to generate a sixth prompt information in response to the third detection data being less than the second endpoint value, the sixth prompt information being used to indicate the possibility that the sample to be tested has at least one of platelet aggregation, large platelets, and abnormally low platelets.

[0068] Specifically, the sample preparation unit stains the sample to be tested with fluorescent dyes so that a large amount of residual nucleic acids in immature red blood cells (RET) and platelets in the sample to be tested are stained, so that RET and PLT can be separated from the red blood cells by judging the intensity of the fluorescence signal. The second detection unit (PLT-O) further separates PLT and RET by the laser signal intensity to obtain the third detection data. Since the laser signal intensity is related to the cell volume, when a large number of large platelets appear, the second detection unit (PLT-O) will mistake the large platelets for reticulocytes during detection, making it possible that the sample to be tested has at least one of platelet aggregation, large platelets, and abnormally low platelets when the third detection data is less than the second endpoint value. At this time, the control unit generates the sixth prompt information; due to the principle of optical detection, the second detection unit can exclude the possibility of the influence of small red blood cells, red blood cell fragments, and cold globulins when re-testing the sample to be tested. When the third detection data is greater than the first endpoint value, the control unit generates the fifth prompt information, and the fifth prompt information is used to indicate the possibility that the sample to be tested has an abnormally high platelet count, so as to generate a platelet detection report according to the fifth prompt information or the sixth prompt information.

[0069] In another embodiment, see Figure 6 , Figure 6 FIG. 4 is a schematic diagram of the detection process of the fourth embodiment of the blood analyzer provided by the present application. Figure 6As shown, the first detection unit is used for detection through PLT-I or PLT-O, the second detection unit is used for platelet detection through PLT-F, the control unit is used for generating fifth prompt information in response to the third detection data being greater than the first endpoint value, the fifth prompt information is used to indicate the possibility that the sample to be tested has abnormally high platelets, and the control unit is used for generating seventh prompt information in response to the third detection data being less than the second endpoint value, the seventh prompt information is used to indicate the possibility that the sample to be tested has platelet aggregation or abnormally low platelets.

[0070] Specifically, the sample preparation unit uses fluorescent dyes to specifically stain the nucleic acid of the platelets of the sample to be tested, so that the second detection unit (PLT-F) can directly separate the PLT from the red blood cells. Due to the specific staining of platelets, the second detection unit (PLT-F) will not mistake large-volume platelets for other types of cells. When the third test data is less than the second endpoint value, the sample to be tested has the possibility of platelet aggregation or abnormally low platelets. At this time, the control unit generates the seventh prompt information; due to the principle of optical detection, the second detection unit can exclude the possibility of the influence of small red blood cells, red blood cell fragments, and cold globulins when re-testing the sample to be tested. When the third test data is greater than the first endpoint value, the control unit generates the fifth prompt information. The fifth prompt information is used to indicate the possibility that the sample to be tested has an abnormally high platelet count, so as to generate a platelet detection report according to the fifth prompt information or the seventh prompt information.

[0071] In an embodiment of the present application, the control unit automatically selects a corresponding processing method to re-examine the sample to be tested according to the configuration of the blood analyzer, so that when the blood analyzer is equipped with PLT-O for reticulocyte detection or when the blood analyzer is equipped with PLT-F for platelet detection, the interference factors of the sample to be tested can be automatically eliminated according to the third test data obtained by the re-examination, thereby reducing the time for manual intervention and processing and improving the accuracy of the platelet test results.

[0072] Optionally, see Figure 7 , Figure 7 FIG. 5 is a schematic diagram of the detection process of the fifth embodiment of the blood analyzer provided by the present application. Figure 7 As shown, the control unit is also used to obtain scattered point data of the third detection unit; the control unit is also used to judge whether the sample to be tested has the possibility of platelet aggregation according to the scattered point data in response to the third detection data being less than the second endpoint value, so as to generate a platelet detection result according to the judgment result.

[0073] Specifically, the blood analyzer can also be equipped with a third detection unit, which is an optical detection unit for white blood cell (WBC) detection. The third detection unit performs five-category counting on the sample to be tested to obtain the white blood cell detection result of the sample to be tested. When the blood analyzer performs detection through the third detection unit, the volume pulse signal and the particle size pulse signal of the sample to be tested are used to generate scatter data of the DIFF channel of the sample to be tested. The scatter data can be presented in the form of a scatter plot. The control unit can determine whether the sample to be tested has the possibility of platelet aggregation through the particle distribution information of the preset area in the scatter plot. For example, the particle distribution information may include information such as particle distribution shape and particle distribution quantity.

[0074] In one embodiment, in response to the first test data being less than the second endpoint value, the control unit further obtains the scattered data of the sample to be tested when the third test unit performs the test, so as to determine whether the sample to be tested has the possibility of platelet aggregation based on the scattered data and generate the platelet test result based on the judgment result. In another embodiment, after the second test unit re-tests the sample to be tested and obtains the third test data, when the third test data is less than the second endpoint value, the sample to be tested may have the possibility of platelet aggregation caused by insufficient disaggregation, and at this time, the control unit determines whether the sample to be tested has the possibility of platelet aggregation based on the scattered data, so as to assist in generating the platelet test result based on the judgment result, so that the abnormal processing and analysis report of the platelet test result are more comprehensive. The blood analyzer of this embodiment can eliminate the interference factors of abnormal platelet detection in a variety of ways, reduce the time of manual intervention and processing, and improve the accuracy of platelet test results.

[0075] Furthermore, the control unit determines whether the sample to be tested has the possibility of platelet aggregation based on the scattered point data, such as Figure 7 As shown, when the scatter data show that platelets may be aggregated, the control unit generates a first prompt information, and the first prompt information is used to indicate the possibility that the sample to be tested has platelet aggregation; when the scatter data show that platelets are not aggregated, the control unit generates an eighth prompt information, and when the second detection unit is the PLT-O detection channel, the eighth prompt information is used to indicate the possibility that the sample to be tested has at least one of abnormally low platelets and large platelets; when the second detection unit is the PLT-F detection channel, the eighth prompt information is used to indicate the possibility that the sample to be tested has abnormally low platelets, so as to generate a platelet detection result according to the first prompt information or the eighth prompt information.

[0076] Optionally, the blood analyzer may further include a visualization interface, which is connected to the control unit. When the control unit generates corresponding prompt information according to different processing methods (such as the first prompt information, the second prompt information, the third prompt information, the fourth prompt information, the fifth prompt information, the sixth prompt information, the seventh prompt information and the eighth prompt information mentioned above), and generates platelet detection results according to the corresponding prompt information, the control unit may transmit the platelet detection results to the visualization interface, so that the user can view the abnormal report of the platelet detection through the visualization interface, or the user can analyze the abnormal processing of the platelet detection through the visualization interface.

[0077] See also Figure 8 , Figure 8 FIG. 1 is a flow chart of an embodiment of the blood analysis method provided by the present application. Figure 8 As shown, the blood analysis method provided in this embodiment includes the following steps:

[0078] Step S11: controlling the first detection unit to perform impedance detection or optical detection on the sample to be detected, so as to obtain first detection data of platelets in the sample to be detected.

[0079] In one embodiment, the first detection unit is an impedance detection unit that detects the sample to be tested by a direct current impedance (DC) method. Since the impedance method distinguishes platelets based on the volume difference of blood cells, the first detection data is easily affected by interference factors such as small red blood cells, cell fragments, microplatelets, giant platelets, platelet aggregation, etc. In another embodiment, the first detection unit can also perform multi-dimensional analysis of the sample to be tested by nucleic acid fluorescence staining and laser scattering to remove interference factors such as small red blood cells and cell fragments in platelet counts.

[0080] In response to the blood analyzer receiving a sample tube carrying a sample to be tested, the first detection unit is controlled to detect the sample to be tested to obtain first detection data, and the first detection data at least includes platelet counting data.

[0081] Step S12: In response to the first test data being greater than the first endpoint value, controlling the blood analyzer to retest the sample to be tested to obtain second test data of the sample to be tested, and generating a platelet test result of the sample to be tested according to the second test data.

[0082] In response to the first test data being greater than the first endpoint value, that is, the platelet test data of the sample to be tested exceeds the upper limit of the preset interval, at this time, the blood analyzer is controlled to re-test the sample to be tested to obtain the second test data of the sample to be tested, and the platelet test result of the sample to be tested is generated according to the second test data. The sample to be tested can be re-tested by the first detection unit, or by a detection unit of other detection methodologies of the blood analyzer, which is not specifically limited here.

[0083] Step S13: In response to the first test data being less than the second endpoint value, generating a platelet test result of the sample to be tested according to the first test data, wherein the first endpoint value is greater than the second endpoint value.

[0084] When the first test data is less than the second endpoint value, that is, the platelet test data of the sample to be tested exceeds the lower limit of the preset interval, at this time, the possibility of abnormal platelet test can be analyzed according to the first test data to generate a platelet test result. The first endpoint value and the second endpoint value are two endpoint values ​​of the preset interval of the platelet test data, and the first endpoint value is greater than the second endpoint value.

[0085] In an embodiment of the present application, when the blood analyzer performs platelet detection on the sample to be tested, the first detection data obtained by the first detection unit is obtained to re-test the sample to be tested when the first detection data is greater than the first endpoint value, so as to eliminate interference factors that may affect the accuracy of the platelet detection, and output the platelet detection result when the first detection data is less than the second endpoint value. This can reduce processing time and improve the efficiency of platelet detection. Since the sample to be tested with abnormal detection is automatically processed, the time for manual intervention and processing can be effectively reduced, the cost can be reduced, and the accuracy of the blood analyzer can be improved.

[0086] See also Fig. 9 , Fig. 9 FIG. 1 is a flow chart of another embodiment of the blood analysis method provided by the present application. Fig. 9 As shown, the blood analysis method provided in this embodiment includes the following steps:

[0087] Step S21: controlling the first detection unit to perform impedance detection or optical detection on the sample to be detected to obtain first detection data.

[0088] Step S21 is the same as step S11 and will not be described again.

[0089] Step S22: Acquire the detection unit carried by the blood analyzer.

[0090] Specifically, the blood analyzer can be equipped with multiple detection units to support the needs of various detection scenarios.

[0091] Step S23: In response to the detection unit including the second detection unit and the first detection data is not within the preset interval, controlling the second detection unit to re-test the sample to be tested to obtain third detection data.

[0092] After obtaining the detection unit carried by the blood analyzer, it is determined whether the detection unit carried by the blood analyzer includes a second detection unit. The second detection unit may be a specific detection unit capable of performing platelet detection on the sample to be tested. For example, the second detection unit may include a laser detection unit (PLT-O) for RET detection and / or a laser detection unit (PLT-F) for PLT detection. When the detection unit includes the second detection unit and the first detection data is not within the preset interval, the second detection unit is controlled to re-test the sample to be tested to obtain the third detection data.

[0093] In response to the detection unit not including the second detection unit and the first detection data not being within the preset interval, the step of controlling the blood analyzer to re-test the sample to be tested or generating a platelet test result of the sample to be tested according to the first detection data is executed. Specifically, in one embodiment, the first detection unit is a PLT-I detection channel, and when the detection unit does not include the second detection unit and the first detection data is greater than the first endpoint value, the incubation unit is controlled to incubate the sample to be tested for a preset time, and the first detection unit is controlled to re-test the sample to be tested after the incubation treatment; when the detection unit does not include the second detection unit and the first detection data is less than the second endpoint value, the platelet test result of the sample to be tested is directly generated according to the first detection data.

[0094] In the embodiment of the present application, the control unit determines whether the detection unit includes a second detection unit by obtaining the detection unit carried by the blood analyzer, so as to automatically select the corresponding processing method according to the configuration of the blood analyzer to re-examine the test sample, thereby reducing the time for manual intervention and processing; the blood analyzer method of this embodiment can flexibly select an effective processing method in combination with the configuration of the blood analyzer, accelerate the generation of platelet test results, and save related manual processing costs, which is conducive to fully automatic abnormal processing of platelet detection.

[0095] See also Fig.10 , Fig.10 Schematic diagram of the structure of an embodiment of the computer-readable storage medium provided by the present application. Fig.10 As shown, the computer-readable storage medium 110 stores program instructions 111 that can implement all the above methods.

[0096] If the integrated units of the functional units in the various embodiments of the present application are implemented in the form of software functional units and sold or used as independent products, they can be stored in a computer-readable storage medium 110. Based on this understanding, the technical solution of the present application, or the part that contributes to the prior art, or all or part of the technical solution can be embodied in the form of a software product, and the computer-readable storage medium 110 includes several instructions in a program instruction 111 to enable a computer device (which can be a personal computer, a system server, or a network device, etc.), an electronic device (such as MP3, MP4, etc., or a mobile terminal such as a mobile phone, a tablet computer, a wearable device, or a desktop computer, etc.) or a processor to execute all or part of the steps of the methods of various implementation methods of the present application.

[0097] Those skilled in the art will appreciate that the embodiments of the present application may be provided as methods, systems, or computer program products. Therefore, the present application may adopt the form of a complete hardware embodiment, a complete software embodiment, or an embodiment combining software and hardware. Moreover, the present application may adopt the form of a computer program product implemented on one or more computer-readable storage media 110 (including but not limited to disk storage, CD-ROM, optical storage, etc.) containing computer-usable program code.

[0098] The present application is described by flowcharts and / or block diagrams of the methods, devices (systems), and computer program products according to the embodiments of the present application. It should be understood that each process and / or box in the flowchart and / or block diagram, as well as the combination of the processes and / or boxes in the flowchart and / or block diagram, can be implemented by a computer-readable storage medium 110. These computer-readable storage media 110 can be provided to a processor of a general-purpose computer, a special-purpose computer, an embedded processor, or other programmable data processing device to generate a machine, so that the program instructions 111 executed by the processor of the computer or other programmable data processing device generate instructions for implementing the process in the flowchart. Figure 1 A process or multiple processes and / or boxes Figure 1 A device that provides the functions specified in a block or multiple blocks.

[0099] These computer-readable storage media 110 may also be stored in a computer-readable memory that can direct a computer or other programmable data processing device to operate in a specific manner, so that the program instructions 111 stored in the computer-readable storage medium 110 produce a manufactured product including an instruction device, which implements the process Figure 1 A process or multiple processes and / or boxes Figure 1 A function specified in one or more boxes.

[0100] These computer-readable storage media 110 can also be loaded onto a computer or other programmable data processing device so that a series of operating steps are executed on the computer or other programmable device to produce a computer-implemented process, thereby providing program instructions 111 executed on the computer or other programmable device for implementing the process. Figure 1 A process or multiple processes and / or boxes Figure 1 A step that specifies a function in one or more boxes.

[0101] Any process or method description in a flowchart or otherwise described herein may be understood to represent a module, segment or portion of code that includes one or more executable instructions for implementing the steps of a specific logical function or process, and the scope of the preferred embodiments of the present application includes alternative implementations in which functions may not be performed in the order shown or discussed, including performing functions in a substantially simultaneous manner or in the reverse order depending on the functions involved, which should be understood by technicians in the technical field to which the embodiments of the present application belong.

[0102] The logic and / or steps represented in the flowchart or described in other ways herein, for example, can be considered as a sequenced list of executable instructions for implementing logical functions, and can be specifically implemented in any computer-readable medium for use by an instruction execution system, device or equipment (which can be a personal computer, server, network device or other system that can fetch instructions from an instruction execution system, device or equipment and execute instructions), or used in combination with these instruction execution systems, devices or equipment. The above description is only an implementation method of the present application, and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made by using the contents of the specification and drawings of this application, or directly or indirectly applied in other related technical fields, is also included in the patent protection scope of the present application.

[0103] The above description is only an implementation method of the present application, and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly used in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A blood analyzer, characterized in that: include: A first detection unit, used for performing impedance detection or optical detection on the sample to be detected, so as to obtain first detection data of platelets of the sample to be detected; a control unit connected to the first detection unit, and configured to determine whether the first detection data is within a preset interval, wherein the preset interval includes a first endpoint value and a second endpoint value, and the first endpoint value is greater than the second endpoint value; Wherein, the control unit is used for generating a platelet test result of the sample to be tested according to the first test data in response to the first test data being less than the second endpoint value; The control unit is further used to control the blood analyzer to retest the sample to be tested in response to the first test data being greater than the first endpoint value, so as to obtain second test data of the sample to be tested, and the control unit is further used to generate a platelet test result of the sample to be tested according to the second test data; Alternatively, the control unit is used to obtain a detection unit carried by the blood analyzer, and the control unit is also used to control the second detection unit to re-test the sample to be tested in response to the detection unit including a second detection unit and the first detection data being not within the preset interval to obtain third detection data, and generate a platelet detection result of the sample to be tested based on the third detection data, and the detection channel of the second detection unit is different from the detection channel of the first detection unit.

2. The blood analyzer according to claim 1, characterized in that: The blood analyzer also includes an incubation unit, which is connected to the control unit. The control unit is used to control the incubation unit to incubate the sample to be tested at a preset temperature in response to the first detection data being greater than the first endpoint value, so that the blood analyzer re-tests the sample to be tested after incubation.

3. The blood analyzer according to claim 1, characterized in that: The second detection unit is connected to the control unit, and the second detection unit is used to perform reticulocyte detection or platelet detection on the sample to be tested; The first detection unit is used to perform impedance detection on the sample to be tested and obtain the first detection data, and the control unit is used to control the second detection unit to perform reticulocyte detection or platelet detection on the sample to be tested in response to the first detection data being greater than the first endpoint value, so as to obtain the second detection data; The first detection unit is used to perform reticulocyte detection on the sample to be tested and obtain the first detection data, and the control unit is used to control the second detection unit to perform platelet detection on the sample to be tested in response to the first detection data being greater than the first endpoint value to obtain the second detection data.

4. The blood analyzer according to any one of claims 1 to 3, characterized in that: The first detection data includes the platelet count data, volume data and distribution density data of the sample to be tested, and the control unit is used to generate a first prompt information when the count data is less than the second endpoint value, and the volume data and / or the distribution density data is greater than a first preset value, and the first prompt information is used to indicate that the sample to be tested has the possibility of platelet aggregation; The control unit is used to generate a second prompt information when the counting data is less than the second endpoint value and the volume data and / or the distribution density data is less than or equal to the first preset value, and the second prompt information is used to indicate the possibility that the sample to be tested has a large volume of platelets or an abnormally low platelet count.

5. The blood analyzer according to claim 2, characterized in that: The control unit is used for generating third prompt information in response to the second detection data being greater than the first endpoint value, and / or in response to the difference between the second detection data and the first detection data being less than a second preset value, wherein the third prompt information is used for indicating the possibility that the sample to be tested has at least one of abnormally high red blood cell fragments, microerythrocytes and platelets; The control unit is used to generate fourth prompt information in response to the second detection data being less than the first endpoint value, and / or the control unit is used to generate fourth prompt information in response to the difference between the second detection data and the first detection data being greater than or equal to a second preset value, wherein the fourth prompt information is used to indicate the possibility that the sample to be tested has the influence of cold globulins.

6. The blood analyzer according to claim 1, characterized in that: The blood analyzer further comprises a sample preparation unit, which is used for adding a disaggregation reagent to the sample to be tested to disaggregate the platelets in the sample to be tested, and the second detection unit is used for retesting the sample to be tested after disaggregation.

7. The blood analyzer according to claim 1 or 6, characterized in that: The second detection unit is used to perform reticulocyte detection, and the control unit is used to generate fifth prompt information in response to the third detection data being greater than the first endpoint value, and the fifth prompt information is used to indicate the possibility that the sample to be tested has abnormally high platelets. The control unit is used to generate sixth prompt information in response to the third detection data being less than the second endpoint value, and the sixth prompt information is used to indicate the possibility that the sample to be tested has at least one of platelet aggregation, large platelets, and abnormally low platelets.

8. The blood analyzer according to claim 1 or 6, characterized in that: The second detection unit is used to perform platelet detection, and the control unit is used to generate fifth prompt information in response to the third detection data being greater than the first endpoint value, and the fifth prompt information is used to indicate the possibility that the sample to be tested has abnormally high platelet count. The control unit is used to generate seventh prompt information in response to the third detection data being less than the second endpoint value, and the seventh prompt information is used to indicate the possibility that the sample to be tested has platelet aggregation or abnormally low platelet count.

9. The blood analyzer according to claim 6, characterized in that: The control unit is also used to obtain scattered point data of the third detection unit; the control unit is also used to judge whether the sample to be tested has the possibility of platelet aggregation according to the scattered point data in response to the third detection data being less than the second endpoint value, so as to generate the platelet detection result according to the judgment result.

10. A blood analysis method, characterized in that: include: Controlling the first detection unit to perform impedance detection or optical detection on the sample to be detected, so as to obtain first detection data of platelets in the sample to be detected; In response to the first test data being greater than a first endpoint value, controlling the blood analyzer to retest the sample to be tested to obtain second test data of the sample to be tested, and generating a platelet test result of the sample to be tested according to the second test data; In response to the first detection data being less than a second endpoint value, generating a platelet detection result of the sample to be tested according to the first detection data, wherein the first endpoint value is greater than the second endpoint value; Alternatively, controlling the first detection unit to perform impedance detection or optical detection on the sample to be tested to obtain the first detection data; Obtaining a detection unit carried by the blood analyzer; In response to the detection unit including a second detection unit and the first detection data being not within a preset interval, the second detection unit is controlled to re-test the sample to be tested to obtain third detection data, and the detection channel of the second detection unit is different from the detection channel of the first detection unit.

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