Povidone iodine solution as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of disinfectants, and provides a povidone iodine solution as well as a preparation method and application thereof. The povidone-iodine solution is prepared from the following raw materials in percentage by mass: 6 to 10 percent of polyvinylpyrrolidone, 3 to 5 percent of elemental iodine, 1.5 to 2.5 percent of cationic polypeptide, 0.1 to 0.2 percent of malic acid, 0.5 to 1.5 percent of stabilizer, 0.1 to 0.5 percent of acid-base buffer pair, 0.15 to 0.25 percent of pH regulator, 0.05 to 0.1 percent of anionic surfactant, 10 to 15 percent of ethanol and the balance of water. The povidone-iodine solution disclosed by the invention has the advantages of self-thickening effect, strong stability, good dispersity, lasting effect, thorough sterilization and better adhesiveness, does not irritate skin, mucous membranes and eyes, and effectively kills bacteria, viruses and the like in a short time at low concentration; the povidone-iodine solution also has the effects of stopping bleeding, eliminating wound free radicals, preventing wound infection and promoting wound healing.

Description

Technical Field

[0001] The invention relates to the technical field of disinfectants, and in particular to a povidone-iodine solution and a preparation method and application thereof. Background Art

[0002] Povidone-iodine solution has different degrees of bactericidal effect on most bacteria, fungi and viruses. The surfactant PVP provides affinity for bacterial membranes, combines the iodine it carries with cell membranes and cytoplasm, and oxidizes sulfhydryl compounds, peptides, proteins, enzymes, lipids, etc., thereby achieving the purpose of sterilization. Povidone-iodine has the characteristics of film formation, adhesion, detoxification, slow release, strong water solubility and spectrum bactericidal effect. It has been increasingly widely used in the sterilization and disinfection of skin mucosa, surgery and instruments.

[0003] Cataract is a common blinding eye disease worldwide, and a large number of cataract patients undergo surgical treatment every year. Infectious endophthalmitis is the most serious complication after cataract surgery. Although the incidence is low, once it occurs, it will cause serious damage to the eyeball and loss of visual function. It is generally believed that the occurrence of endophthalmitis is closely related to the normal flora in the conjunctival sac entering the eye through the surgical incision. About 2 / 3 of normal people have normal flora in the conjunctival sac. Under trauma or surgical conditions, bacteria in the conjunctival sac can cause bacterial endophthalmitis. 80% of the pathogens of infectious endophthalmitis come from the bacterial flora in the patient's conjunctival sac. The use of povidone-iodine in the conjunctival sac before surgery is considered to be the most effective method. Povidone-iodine has the characteristics of non-sensitization, non-irritation, strong permeability, and long-lasting effect, making it an ideal drug for disinfection, debridement, and prevention of infection. However, the existing povidone-iodine solution has the disadvantages of poor stability, short action time, and limited effect.

[0004] Therefore, it is of great significance to provide a povidone-iodine solution with long-term stability and good bactericidal and anti-inflammatory effects. Summary of the invention

[0005] The purpose of the present invention is to provide a povidone-iodine solution and a preparation method and application thereof in view of the deficiencies in the prior art.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The present invention provides a povidone-iodine solution, which comprises the following raw materials in mass fractions:

[0008] Polyvinyl pyrrolidone 6-10%, elemental iodine 3-5%, cationic polypeptide 1.5-2.5%, malic acid 0.1-0.2%, stabilizer 0.5-1.5%, acid-base buffer 0.1-0.5%, pH adjuster 0.15-0.25%, anionic surfactant 0.05-0.1%, ethanol 10-15%, and the balance is water.

[0009] Preferably, the polyvinyl pyrrolidone comprises polyvinyl pyrrolidone K25 and polyvinyl pyrrolidone K30, and the mass ratio of the polyvinyl pyrrolidone K25 to the polyvinyl pyrrolidone K30 is 1:2-3.

[0010] Preferably, the cationic polypeptide is polylysine and / or polyarginine.

[0011] Preferably, the stabilizer comprises potassium iodate and hydroxypropyl methylcellulose, and the mass ratio of potassium iodate to hydroxypropyl methylcellulose is 2 to 3:1.

[0012] Preferably, the acid-base buffer pair comprises potassium dihydrogen phosphate and dipotassium hydrogen phosphate, and the mass ratio of the potassium dihydrogen phosphate to the dipotassium hydrogen phosphate is 1-3:1-3.

[0013] Preferably, the pH regulator is sodium tripolyphosphate or sodium hexametaphosphate.

[0014] Preferably, the anionic surfactant is sodium dodecylbenzene sulfonate and / or sodium dodecyl sulfate.

[0015] The present invention also provides a method for preparing the povidone-iodine solution, comprising the following steps:

[0016] 1) mixing elemental iodine, a stabilizer, an acid-base buffer pair, a pH adjuster and part of water to obtain a mixture;

[0017] mixing polyvinyl pyrrolidone and remaining water to obtain a polyvinyl pyrrolidone solution;

[0018] 2) reacting the polyvinyl pyrrolidone solution and the mixture, and mixing the reaction product, the cationic polypeptide, malic acid, anionic surfactant and ethanol to obtain a povidone iodine solution.

[0019] Preferably, the mass ratio of the partial water to the remaining water is 1:2-3; the reaction temperature in step 2) is 55-65°C, the reaction time is 4-5h, and the reaction is carried out under stirring at a rate of 300-500r / min.

[0020] The invention also provides application of the povidone-iodine solution in bactericidal disinfectants.

[0021] The beneficial effects of the present invention include the following:

[0022] 1) In the present invention, cationic polypeptide, malic acid, polyvinyl pyrrolidone and iodine have good synergistic bactericidal effect and effectively stabilize iodine molecules. Polyglutamic acid and malic acid can also improve the complexation of povidone and iodine, improve its stability, and slow down the release of free iodine. Sodium tripolyphosphate and hydroxypropyl methylcellulose are combined to have good adhesion, prolong the disinfection time of povidone-iodine solution, and improve disinfection efficiency. The acid-base buffer, pH adjuster and stabilizer work together to ensure the stability of the effective iodine content and improve the bactericidal effect of povidone-iodine solution.

[0023] 2) The povidone-iodine solution of the present invention has self-thickening effect, strong stability, good dispersibility, long-lasting effect, thorough sterilization, good adhesion, no stimulation to skin, mucous membrane and eyes, high safety, and can effectively kill bacteria, viruses, etc. in a short time and at a low concentration; the povidone-iodine solution also has the effects of stopping bleeding, eliminating wound free radicals, preventing wound infection and promoting wound healing. DETAILED DESCRIPTION

[0024] The present invention provides a povidone-iodine solution, which comprises the following raw materials in mass fractions:

[0025] Polyvinyl pyrrolidone 6-10%, elemental iodine 3-5%, cationic polypeptide 1.5-2.5%, malic acid 0.1-0.2%, stabilizer 0.5-1.5%, acid-base buffer 0.1-0.5%, pH adjuster 0.15-0.25%, anionic surfactant 0.05-0.1%, ethanol 10-15%, and the balance is water.

[0026] In the present invention, the povidone-iodine solution contains 6 to 10% of polyvinyl pyrrolidone, preferably 7 to 9%, and more preferably 8%.

[0027] In the present invention, the polyvinyl pyrrolidone preferably comprises polyvinyl pyrrolidone K25 and polyvinyl pyrrolidone K30, and the mass ratio of polyvinyl pyrrolidone K25 (PVP K25) to polyvinyl pyrrolidone K30 (PVP K30) is preferably 1:2-3, more preferably 1:2.2-2.8, and more preferably 1:2.4-2.5.

[0028] There are a large number of polar groups in polyvinyl pyrrolidone, such as hydroxyl and carbonyl, which can form hydrogen bonds with water molecules, thereby increasing the solubility of iodine molecules in water; polyvinyl pyrrolidone also has good coating ability, which can coat iodine molecules to form stable complexes, effectively avoiding the aggregation and precipitation of iodine molecules, and improving their solubility in water. The present invention uses a mixture of PVP K25 and PVP K30 to complex more iodine, reduce the presence of free iodine in the solution, and gradually release iodine from povidone iodine during use, which has a sustained release effect, maintains long-term bactericidal ability, and improves bactericidal and disinfection effects.

[0029] In the present invention, the povidone-iodine solution contains 5 to 8% of elemental iodine, preferably 6 to 7%, and more preferably 6.5%.

[0030] In the present invention, the povidone-iodine solution contains 1.5 to 2.5% of the cationic polypeptide, preferably 1.8 to 2.2%, and more preferably 2%.

[0031] In the present invention, the cationic polypeptide is preferably polylysine and / or polyarginine.

[0032] In the present invention, the povidone-iodine solution contains 0.1 to 0.2% of malic acid, preferably 0.12 to 0.18%, and more preferably 0.14 to 0.15%.

[0033] Malic acid contains polar groups such as hydroxyl and carboxyl groups, which can form hydrogen bonds with water molecules, prevent iodine ions from contacting with hydrogen ions in water, and further reduce the dissociation of povidone iodine.

[0034] In the present invention, the povidone-iodine solution contains 0.5 to 1.5% of a stabilizer, preferably 0.8 to 1.2%, and more preferably 1%.

[0035] In the present invention, the stabilizer preferably comprises potassium iodate and hydroxypropyl methylcellulose, and the mass ratio of potassium iodate to hydroxypropyl methylcellulose is preferably 2-3:1, more preferably 2.2-2.8:1, and more preferably 2.4-2.5:1.

[0036] In the present invention, the viscosity of the hydroxypropyl methylcellulose is preferably ≥1000 mPa·s, and more preferably ≥1500 mPa·s.

[0037] In the present invention, during the storage process, the povidone-iodine solution continuously dissociates iodine, and the iodine reacts with water to generate HIO and I -, and HIO further disproportionates to generate HIO3 to promote the reaction, which makes the povidone iodine decrease and the content decrease. When there is an appropriate amount of potassium iodate in the solution, the concentration of iodate ions in the solution is increased, the generation reaction of iodate ions is inhibited, and the dissociation of povidone iodine is effectively avoided or slowed down, thereby increasing the stability of povidone iodine; Hydroxypropyl methylcellulose has the effects of self-thickening, stabilizing the solution and moisturizing.

[0038] In the present invention, the povidone-iodine solution contains 0.1-0.5% of an acid-base buffer solution, preferably 0.2-0.4%, and more preferably 0.3%.

[0039] In the present invention, the acid-base buffer pair preferably comprises potassium dihydrogen phosphate and dipotassium hydrogen phosphate, and the mass ratio of the potassium dihydrogen phosphate to the dipotassium hydrogen phosphate is preferably 1-3:1-3, more preferably 1-2:1-2, and more preferably 1:1.

[0040] In the present invention, the acid-base buffer pair can maintain the acid-base balance of the solution and play a buffering role.

[0041] In the present invention, the povidone-iodine solution contains 0.15 to 0.25% of a pH adjuster, preferably 0.18 to 0.22%, and more preferably 0.2%.

[0042] In the present invention, the pH regulator is preferably sodium tripolyphosphate or sodium hexametaphosphate; sodium tripolyphosphate and sodium hexametaphosphate can complex a small amount of free iodine, improve the sustained release effect of povidone iodine, and prolong the antibacterial and disinfection effects of povidone iodine solution.

[0043] In the present invention, the povidone-iodine solution contains 0.05 to 0.1% of anionic surfactant, preferably 0.06 to 0.09%, and more preferably 0.07 to 0.08%.

[0044] In the present invention, the anionic surfactant is preferably sodium dodecylbenzene sulfonate and / or sodium dodecyl sulfate.

[0045] In the present invention, the adsorption of the anionic surfactant forms a molecular film around the povidone-iodine molecules, which becomes a barrier layer to prevent collision, aggregation and sedimentation between particles, thereby inhibiting the dissociation of iodine from povidone-iodine and the degradation of iodine.

[0046] The present invention also provides a method for preparing the povidone-iodine solution, comprising the following steps:

[0047] 1) mixing elemental iodine, a stabilizer, an acid-base buffer pair, a pH adjuster and part of water to obtain a mixture;

[0048] mixing polyvinyl pyrrolidone and remaining water to obtain a polyvinyl pyrrolidone solution;

[0049] 2) reacting the polyvinyl pyrrolidone solution and the mixture, and mixing the reaction product, the cationic polypeptide, malic acid, anionic surfactant and ethanol to obtain a povidone iodine solution.

[0050] In the present invention, the mass ratio of the partial water to the remaining water is preferably 1:2-3, and more preferably 1:2.5; the temperature of the reaction in step 2) is preferably 55-65°C, and more preferably 60°C; the reaction time is preferably 4-5h, and more preferably 4.5h; the reaction is carried out under stirring, and the stirring rate is preferably 300-500r / min, and more preferably 350-450r / min, and more preferably 400r / min.

[0051] The invention also provides application of the povidone-iodine solution in bactericidal disinfectants.

[0052] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0053] In the examples and comparative examples, the weight average molecular weight of PVP K25 is 32,000, and the weight average molecular weight of PVP K30 is 37,900; the viscosity of hydroxypropyl methylcellulose is 1,500 mPa·s; the molecular weight of polylysine is 4,000 Da, and the molecular weight of polyarginine is 50,000 Da.

[0054] Example 1

[0055] The povidone-iodine solution comprises the following raw materials in mass fractions: 7% polyvinyl pyrrolidone, 3% elemental iodine, 1.5% cationic polypeptide, 0.2% malic acid, 0.8% stabilizer, 0.2% acid-base buffer pair, 0.18% pH adjuster, 0.07% anionic surfactant, 12% ethanol, and the balance is water; the polyvinyl pyrrolidone comprises PVPK25 and PVPK30 in a mass ratio of 1:2.2, the cationic polypeptide is polylysine, the stabilizer comprises potassium iodate and hydroxypropyl methylcellulose in a mass ratio of 2.2:1, the acid-base buffer pair comprises potassium dihydrogen phosphate and dipotassium hydrogen phosphate in a mass ratio of 1:2, the pH adjuster is sodium tripolyphosphate, and the anionic surfactant is sodium dodecylbenzene sulfonate.

[0056] The elemental iodine, the stabilizer, the acid-base buffer pair, the pH regulator and one third of the water are mixed uniformly to obtain a mixture; polyvinyl pyrrolidone and the remaining water are mixed to obtain a polyvinyl pyrrolidone solution; the polyvinyl pyrrolidone solution and the mixture are reacted at 55° C. and a stirring rate of 350 r / min for 5 hours, and the reaction product, the cationic polypeptide, malic acid, the anionic surfactant and ethanol are mixed uniformly to obtain a povidone iodine solution.

[0057] Example 2

[0058] The povidone-iodine solution comprises the following raw materials in mass fractions: 9% polyvinyl pyrrolidone, 4.5% elemental iodine, 2.2% cationic polypeptide, 0.12% malic acid, 1.5% stabilizer, 0.4% acid-base buffer pair, 0.25% pH adjuster, 0.1% anionic surfactant, 15% ethanol, and the balance is water; the polyvinyl pyrrolidone comprises PVPK25 and PVPK30 in a mass ratio of 1:2.8, the cationic polypeptide is polyarginine, the stabilizer comprises potassium iodate and hydroxypropyl methylcellulose in a mass ratio of 2.8:1, the acid-base buffer pair comprises potassium dihydrogen phosphate and dipotassium hydrogen phosphate in a mass ratio of 2:1, the pH adjuster is sodium hexametaphosphate, and the anionic surfactant is sodium dodecyl sulfate.

[0059] The elemental iodine, the stabilizer, the acid-base buffer pair, the pH regulator and one quarter of the water are mixed uniformly to obtain a mixture; polyvinyl pyrrolidone and the remaining water are mixed to obtain a polyvinyl pyrrolidone solution; the polyvinyl pyrrolidone solution and the mixture are reacted at 65° C. and a stirring rate of 500 r / min for 4 hours, and the reaction product, the cationic polypeptide, malic acid, the anionic surfactant and ethanol are mixed uniformly to obtain a povidone iodine solution.

[0060] Example 3

[0061] The povidone-iodine solution comprises the following raw materials in mass fractions: 8% polyvinyl pyrrolidone, 4% elemental iodine, 2% cationic polypeptide, 0.15% malic acid, 1% stabilizer, 0.3% acid-base buffer pair, 0.2% pH adjuster, 0.07% anionic surfactant, 14% ethanol, and the balance is water; the polyvinyl pyrrolidone comprises PVPK25 and PVPK30 in a mass ratio of 1:2.5, the cationic polypeptide is polylysine, the stabilizer comprises potassium iodate and hydroxypropyl methylcellulose in a mass ratio of 2.5:1, the acid-base buffer pair comprises potassium dihydrogen phosphate and dipotassium hydrogen phosphate in a mass ratio of 1:1, the pH adjuster is sodium tripolyphosphate, and the anionic surfactant is sodium dodecylbenzene sulfonate.

[0062] The elemental iodine, the stabilizer, the acid-base buffer pair, the pH regulator and one third of the water are mixed uniformly to obtain a mixture; polyvinyl pyrrolidone and the remaining water are mixed to obtain a polyvinyl pyrrolidone solution; the polyvinyl pyrrolidone solution and the mixture are reacted at 60° C. and a stirring rate of 400 r / min for 4.5 hours, and the reaction product, the cationic polypeptide, malic acid, the anionic surfactant and ethanol are mixed uniformly to obtain a povidone iodine solution.

[0063] Comparative Example 1

[0064] The polylysine and sodium dodecylbenzene sulfonate in Example 3 were omitted, the polyvinyl pyrrolidone was a single PVPK25, and the other conditions were the same as in Example 3.

[0065] Comparative Example 2

[0066] The malic acid and hydroxypropyl methylcellulose in Example 3 were omitted, the polyvinyl pyrrolidone was changed to PVPK30, and the other conditions were the same as those in Example 3.

[0067] Application Example 1

[0068] The povidone-iodine solutions of Examples 1 to 3 and Comparative Examples 1 to 2 were tested for stability at room temperature and in the dark. The povidone-iodine solutions of Examples 1 to 3 were all reddish brown viscous liquids without stratification within 36 months. The effective iodine loss rates and free iodine contents of Examples 1 to 3 and Comparative Examples 1 to 2 are shown in Table 1.

[0069] The calculation method of the effective iodine content is as follows: the povidone-iodine solutions of Examples 1 to 3 and Comparative Examples 1 to 2 are diluted with purified water to obtain povidone-iodine solutions with an effective iodine content of 1.1%, and titrated with 0.02 mol / L sodium thiosulfate, where each milliliter of sodium thiosulfate is equivalent to 2.538 g of iodine. The povidone-iodine solution is placed in a constant temperature and humidity chamber at 25°C and 60%RH, and the iodine content is measured at 0, 3, 6, 9, 12, 18, 24, and 36 months, respectively. Among them, the effective iodine content in the povidone-iodine solution at month 0 is 1.1%, and the iodine content is measured based on the volume of sodium thiosulfate consumed at months 3, 6, 9, 12, 18, 24, and 36, and the effective iodine loss rate is calculated.

[0070] Testing method for free iodine content: Purified water was added to the povidone iodine solutions of Examples 1 to 3 and Comparative Examples 1 to 2 to obtain povidone iodine solutions with a povidone iodine mass concentration of 5%, and the free iodine content was tested.

[0071] Table 1 Effective iodine loss rate and free iodine content of Examples and Comparative Examples

[0072]

[0073]

[0074] As can be seen from Table 1, the povidone-iodine solution of the present invention has excellent long-term stability.

[0075] Application Example 2

[0076] The povidone-iodine solution of Examples 1 to 3 was disinfected and tested: 600 patients who underwent cataract phacoemulsification combined with intraocular lens implantation in a hospital within 9 months were selected, including 310 males and 290 females, aged 50 to 70 years old, and were randomly divided into 3 groups. Each group used the povidone-iodine solution of Examples 1 to 3, and the skin disinfection was carried out in accordance with the specifications. The preoperative medication, preoperative treatment, postoperative medication, and postoperative treatment of the three groups of patients were the same. Exclusion criteria: patients with eye infections such as eyelids, eyelid margins, conjunctiva, and cornea, unobstructed tear duct flushing, or acute or chronic dacryocystitis. All patients were prepared for surgery according to the same standard, and the liquid was prepared with 0.9% sodium chloride injection. 8 minutes before the operation, 0.3% povidone-iodine solution (effective iodine content is 0.3%, and the povidone-iodine solutions of Examples 1 to 3 are prepared with purified water) is used to disinfect the periorbital area and the eyelid margin, and 2 mL of 0.2% povidone-iodine solution (0.25% povidone-iodine solution refers to a povidone-iodine solution with an effective iodine content of 0.2%, and 0.2% povidone-iodine solution is prepared with the povidone-iodine solutions of Examples 1 to 3 with purified water) is dripped into the lower fornix, avoiding the cornea, and staying for 30s, 60s, and 90s respectively. Afterwards, it is rinsed with 0.9% sodium chloride injection. The three groups were tested for corneal edema grading, conjunctival hyperemia, and bacterial reduction rate, respectively.

[0077] Corneal edema grading standard: Grade 0: transparent cornea, no edema; Grade 1: localized misty corneal edema, smooth corneal endothelial surface, and clearly visible iris texture; Grade 2: light gray corneal edema, rough corneal endothelial surface, and blurred iris texture; Grade 3: diffuse grayish white corneal edema, cracked corneal endothelial surface, and unclear iris texture; Grade 4: milky white corneal edema, and unclear intraocular structures.

[0078] The corneal edema grading test results are as follows: 90% of the povidone-iodine solution of Example 1 is grade 0, and 10% is grade 1; 92% of the povidone-iodine solution of Example 2 is grade 0, and 8% is grade 1; 94% of the povidone-iodine solution of Example 3 is grade 0, and 6% is grade 1.

[0079] Grading standard for bulbar conjunctival congestion: Grade 1: no congestion (-); Grade 2: mild congestion (+), congestion is limited to the palpebral fissure, and the blood vessels are bright red; Grade 3: moderate congestion (++), congestion is obvious to the fornix, and the blood vessels are dark red; Grade 4: severe congestion (+++), the entire conjunctiva is diffusely congested, and the blood vessels are purple-red and blurred.

[0080] The results of the conjunctival congestion grading test were as follows: 88% of the povidone-iodine solution of Example 1 was grade 0, and 12% was grade 1; 91% of the povidone-iodine solution of Example 2 was grade 0, and 9% was grade 1; 93% of the povidone-iodine solution of Example 3 was grade 0, and 7% was grade 1.

[0081] The bacterial reduction rate after eye disinfection with the povidone-iodine solution of Example 1 was 55%, the bacterial reduction rate after eye disinfection with the povidone-iodine solution of Example 2 was 58%, and the bacterial reduction rate after eye disinfection with the povidone-iodine solution of Example 3 was 62%.

[0082] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A povidone-iodine solution, characterized in that Povidone-iodine solution contains the following raw materials by mass fraction: Polyvinyl pyrrolidone 6-10%, elemental iodine 3-5%, cationic polypeptide 1.5-2.5%, malic acid 0.1-0.2%, stabilizer 0.5-1.5%, acid-base buffer 0.1-0.5%, pH adjuster 0.15-0.25%, anionic surfactant 0.05-0.1%, ethanol 10-15%, and the balance is water.

2. The povidone-iodine solution according to claim 1, characterized in that The polyvinyl pyrrolidone comprises polyvinyl pyrrolidone K25 and polyvinyl pyrrolidone K30, and the mass ratio of the polyvinyl pyrrolidone K25 to the polyvinyl pyrrolidone K30 is 1:2-3.

3. The povidone-iodine solution according to claim 1 or 2, characterized in that The cationic polypeptide is polylysine and / or polyarginine.

4. The povidone-iodine solution according to claim 3, characterized in that The stabilizer comprises potassium iodate and hydroxypropyl methylcellulose, and the mass ratio of the potassium iodate to the hydroxypropyl methylcellulose is 2 to 3:

1.

5. The povidone-iodine solution according to claim 4, characterized in that The acid-base buffer pair comprises potassium dihydrogen phosphate and dipotassium hydrogen phosphate, and the mass ratio of the potassium dihydrogen phosphate to the dipotassium hydrogen phosphate is 1-3:1-3.

6. The povidone-iodine solution according to claim 4, characterized in that The pH regulator is sodium tripolyphosphate or sodium hexametaphosphate.

7. The povidone-iodine solution according to claim 5 or 6, characterized in that The anionic surfactant is sodium dodecylbenzene sulfonate and / or sodium dodecyl sulfate.

8. The method for preparing the povidone-iodine solution according to any one of claims 1 to 7, characterized in that: The following steps are included: 1) mixing elemental iodine, a stabilizer, an acid-base buffer pair, a pH adjuster and part of water to obtain a mixture; mixing polyvinyl pyrrolidone and remaining water to obtain a polyvinyl pyrrolidone solution; 2) reacting the polyvinyl pyrrolidone solution and the mixture, and mixing the reaction product, the cationic polypeptide, malic acid, anionic surfactant and ethanol to obtain a povidone iodine solution.

9. The preparation method according to claim 8, characterized in that: The mass ratio of the partial water to the remaining water is 1:2-3; the reaction temperature in step 2) is 55-65°C, the reaction time is 4-5h, and the reaction is carried out under stirring at a stirring rate of 300-500r / min.

10. Use of the povidone-iodine solution according to any one of claims 1 to 7 in a bactericidal disinfectant.

Images