Manipulation and use of antigen-specific regulatory t cells

CN119307446APending Publication Date: 2025-01-14THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
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Patent Information

Application Number
CN202411157885.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2019-08-05
Filing Date
2020-08-05
Publication Date
2025-01-14

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Abstract

The present invention provides compositions and methods for isolating, manipulating mammalian MHC class I restrictive antigen-specific regulatory T cells, and for therapeutic and other purposes. The regulatory T cells may be characterized as CD8 + cells that specifically inhibit the response of autoreactive and / or pathogenic CD4 + T cells by cytotoxic mechanisms, including but not limited to Perforin, other components of the Perforin / granzyme apoptosis pathway, and the like. The regulatory T cells have antigen specificity but are not activated by the same antigen as the autoreactive and / or pathogenic CD4 + T cells. In a human body, the regulatory T cells express an inhibitory KIR protein, such as one or more of KIR2DL2, KIR2DL3, and KIR3DL1.
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