Optical fiber for laser ablation and laser ablation system

Abstract

The invention discloses an optical fiber for laser ablation and a laser ablation system, and the optical fiber comprises an optical fiber body which is provided with a light-emitting part, and the light-emitting part is close to one end of the optical fiber body; wherein the light-emitting part comprises a plurality of areas, at least two areas in the plurality of areas are used for emitting light with different wavelengths, and / or the plurality of areas comprise non-light-emitting areas, so that the light-emitting part can emit light in different areas in at least one direction of the optical fiber body. According to the optical fiber disclosed by the embodiment of the invention, regional light emitting can be realized, so that energy dispersion can be realized, and a scorching phenomenon caused by energy concentration can be effectively avoided.

Description

Technical Field

[0001] The present disclosure generally relates to the field of medical device technology. More specifically, the present disclosure relates to an optical fiber for laser ablation and a laser ablation system. Background Art

[0002] Laser ablation is a new tumor treatment technology that uses optical fiber to introduce light energy into the human body, causing local biological tissue to coagulate and necrotize after being heated. It can achieve the purpose of removing in situ tumors or lesions with less invasion. Compared with traditional surgical resection, this method has the characteristics of short operation time, small surgical trauma, rarely causing heavy bleeding, less pain to patients, good postoperative recovery effect, and certain anti-inflammatory and bactericidal effects. It has a good prospect in disease treatment, especially in tumor treatment research. It has been used to treat many types of tumors, such as tumors in the liver, brain, breast, retina, etc.

[0003] Current ablation optical fibers usually have a complete light-emitting section. Figure 1 As shown in , the ablation optical fiber 100 has a whole section of light emitting portion 110 for emitting continuous energy light and can only emit light of one wavelength. However, it can be seen from the energy distribution 120 in the figure that a whole section of light emitting portion 110 continuously emits light of the same wavelength, which will cause the energy in the central area of ​​the light emitting portion 110 to be concentrated, resulting in a higher central temperature, and thus there is a risk of burning surrounding tissues during the ablation process.

[0004] In view of this, there is an urgent need to provide a new optical fiber for laser ablation so as to effectively avoid energy concentration and the risk of burning. Summary of the invention

[0005] In order to at least solve one or more of the technical problems mentioned above, the present disclosure proposes optical fiber and laser ablation system solutions for laser ablation in multiple aspects.

[0006] In a first aspect, the present disclosure provides an optical fiber for laser ablation, comprising: an optical fiber body, having a light output portion, wherein the light output portion is close to one end of the optical fiber body; wherein the light output portion comprises a plurality of regions, at least two of the plurality of regions are used to emit light of different wavelengths, and / or the plurality of regions include a non-light output region, so that the light output portion can emit light in separate regions in at least one direction along the optical fiber body.

[0007] In some embodiments, the light output portion includes a first area and a second area, wherein the first area and the second area are used to emit light of different wavelengths; or the first area is a light output area, and the second area is a non-light output area; in at least one direction along the optical fiber body, the first area is separated by the second area, so that the light output portion can emit light in different areas in the at least one direction.

[0008] In some other embodiments, the wavelength of light emitted from the second region is smaller than the wavelength of light emitted from the first region.

[0009] In some embodiments, in at least the axial direction and / or the circumferential direction along the optical fiber body, the first region is divided into a plurality of light-emitting segments by the second region.

[0010] In some other embodiments, at least two light emitting segments among the plurality of light emitting segments are used to emit light of different wavelengths.

[0011] In some further embodiments, along the axial direction of the optical fiber body, the first region is divided into a plurality of light-emitting segments by the second region, wherein two adjacent light-emitting segments are used to emit light of different wavelengths.

[0012] In some embodiments, along the circumferential direction of the optical fiber body, the first region is divided into a plurality of light-emitting segments by the second region, and the plurality of light-emitting segments are symmetrically or evenly distributed around the central axis of the optical fiber body.

[0013] In some other embodiments, the plurality of light emitting segments are symmetrically distributed around the center, wherein at least one pair of two mutually symmetrical light emitting segments are used to emit light of different wavelengths.

[0014] In some further embodiments, in the axial direction and the circumferential direction along the optical fiber body, the first region is divided into a plurality of light output segments by the second region, wherein a portion of the plurality of light output segments are distributed along the circumferential direction, and another portion of the plurality of light output segments are distributed along the axial direction.

[0015] In some embodiments, at least one of the plurality of light output segments includes a plurality of light output blocks, and the plurality of light output blocks are distributed in an array.

[0016] In some other embodiments, at least two light output blocks among the plurality of light output blocks are used to output light of different wavelengths.

[0017] In some further embodiments, at least one of the plurality of light emitting segments has a gradually varying transmittance so as to emit light of gradually varying wavelengths.

[0018] In some embodiments, the plurality of regions have a gradually varying transmittance, so that the plurality of regions are used to emit light of gradually varying wavelengths.

[0019] In some embodiments, at least two of the plurality of light emitting segments have different light emitting shapes, and the light emitting shapes include emitted diffuse light, side light, or annular light.

[0020] In some further embodiments, at least two of the multiple regions have different light emission shapes, and the light emission shapes include emitted diffuse light, side light, or annular light.

[0021] In some other embodiments, at least a portion of the first region is spirally wound around the optical fiber body, and the second region is formed between the spiral first regions.

[0022] In some further embodiments, the spiral first region has a gradually changing transmittance along its spiral extension direction, so as to emit light of gradually changing wavelengths.

[0023] In some embodiments, at least two of the plurality of regions are used to emit light with a wavelength of 980 nm and light with a wavelength of 1064 nm, respectively.

[0024] In a second aspect, the present disclosure provides a laser ablation system, comprising the optical fiber as described in any one of the first aspects of the present disclosure.

[0025] In the optical fiber solution for laser ablation provided above, the disclosed embodiment configures the light output portion to include a plurality of regions so that the light output portion can output light in different regions in at least one direction along the optical fiber body, thereby achieving energy dispersion and effectively avoiding energy concentration that fails to achieve the expected ablation effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] By reading the detailed description below with reference to the accompanying drawings, the above and other objects, features and advantages of the exemplary embodiments of the present disclosure will become readily understood. In the accompanying drawings, several embodiments of the present disclosure are shown in an exemplary and non-limiting manner, and the same or corresponding reference numerals represent the same or corresponding parts, wherein:

[0027] Figure 1 A schematic diagram of an ablation optical fiber having a whole section of a light emitting portion is shown;

[0028] Figure 2a - Figure 2d A schematic diagram showing an optical fiber for laser ablation according to various embodiments of the present disclosure;

[0029] Figure 3a - Figure 3c A schematic diagram showing an optical fiber including multiple light-emitting sections according to multiple embodiments of the present disclosure is shown;

[0030] Figure 3d A schematic diagram showing a scenario in which the optical fiber according to the disclosed embodiment is used to ablate a heterogeneous lesion;

[0031] Figure 4a A schematic diagram showing an optical fiber according to an embodiment of the present disclosure, wherein a plurality of light-emitting segments are separated along the circumferential direction of the optical fiber body;

[0032] Figure 4b Shows Figure 4a A schematic diagram of an application scenario of optical fiber shown;

[0033] Figure 4c A schematic diagram of an optical fiber according to an embodiment of the present disclosure is shown in which a plurality of light-emitting segments are symmetrically distributed along the circumferential direction of the optical fiber body;

[0034] Figure 4d Shows Figure 4c A schematic cross-sectional view of the optical fiber shown;

[0035] Figure 4e A schematic diagram of an optical fiber with multiple light-emitting sections evenly distributed along the circumferential direction of the optical fiber body according to an embodiment of the present disclosure is shown;

[0036] Figure 4f Shows Figure 4e A schematic cross-sectional view of the optical fiber shown;

[0037] Figure 5a A schematic diagram showing an optical fiber having a plurality of light-emitting segments separated in the circumferential direction and the axial direction along the optical fiber body according to some embodiments of the present disclosure is shown;

[0038] Figure 5b Schematic diagrams showing optical fibers having a plurality of light-emitting segments separated in the circumferential direction and the axial direction of the optical fiber body according to other embodiments of the present disclosure;

[0039] Figure 6a A schematic diagram showing an optical fiber including a plurality of light output blocks according to some embodiments of the present disclosure;

[0040] Figure 6b Schematic diagrams showing optical fibers including multiple light output blocks according to other embodiments of the present disclosure;

[0041] Figure 7a A schematic diagram showing an optical fiber having a helical first region according to an embodiment of the present disclosure;

[0042] Figure 7b Schematic diagram of an optical fiber with a graded pitch of a helical first region according to an embodiment of the present disclosure. DETAILED DESCRIPTION

[0043] The following will be combined with the drawings in the embodiments of the present disclosure to clearly and completely describe the technical solutions in the embodiments of the present disclosure. Obviously, the described embodiments are part of the embodiments of the present disclosure, not all of the embodiments. Based on the embodiments in the present disclosure, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present disclosure.

[0044] It should be understood that the terms "include" and "comprising" used in the specification and claims of the present disclosure indicate the presence of described features, integers, steps, operations, elements and / or components, but do not exclude the presence or addition of one or more other features, integers, steps, operations, elements, components and / or collections thereof.

[0045] It should also be understood that the terms used in this disclosure are only for the purpose of describing specific embodiments and are not intended to limit the disclosure. As used in this disclosure and claims, the singular forms of "a", "an", and "the" are intended to include the plural forms unless the context clearly indicates otherwise. It should also be further understood that the term "and / or" used in this disclosure and claims refers to any combination of one or more of the associated listed items and all possible combinations, including these combinations.

[0046] As used in this specification and claims, the term "if" may be interpreted as "when" or "upon" or "in response to determining" or "in response to detecting," depending on the context. Similarly, the phrase "if it is determined" or "if [described condition or event] is detected" may be interpreted as meaning "upon determination" or "in response to determining" or "upon detection of [described condition or event]" or "in response to detecting [described condition or event]," depending on the context.

[0047] In the description of the present disclosure, it is necessary to understand that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating orientations or positional relationships, are orientations or positional relationships based on the drawings, and are only for the convenience of describing the present disclosure and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present disclosure.

[0048] The specific implementation of the present disclosure is described in detail below with reference to the accompanying drawings.

[0049] Figure 2a - Figure 2d Schematic diagram of optical fiber for laser ablation according to multiple embodiments of the present disclosure is shown. Figure 2aA schematic diagram of an optical fiber including multiple regions according to some embodiments of the present disclosure is shown. Figure 2b A schematic diagram of an optical fiber including a non-light-emitting region according to some embodiments of the present disclosure is shown. Figure 2c A schematic diagram of an optical fiber with a first region separated by a second region according to some embodiments of the present disclosure is shown. Figure 2d Schematic diagrams of optical fibers including multiple light output regions according to other embodiments of the present disclosure are shown.

[0050] like Figure 2a - Figure 2d As shown in , the optical fiber 200 for laser ablation may include: an optical fiber body 210, which has a light emitting portion 220, and the light emitting portion 220 is close to one end of the optical fiber body 210. In some embodiments, the optical fiber body 210 may include a core and a cladding, wherein the cladding is coated on the outer surface of the core, and the light emitting portion 220 may emit light by, for example, etching the cladding, or doping a dispersant in the cladding, or removing the cladding at the position of the light emitting portion and coating the outer surface of the core. The position of the light emitting portion 220 can usually be set close to the end of the optical fiber body 210 for inserting into the lesion for ablation. The end close to the optical fiber body 210 means that the light emitting portion 220 is closer to the end for ablation than the other end of the optical fiber body for connecting with the laser. In other embodiments, the end of the light emitting portion 220 close to the optical fiber body 210 may include the end of the light emitting portion 220 covering the end, or the end that does not cover the end.

[0051] like Figure 2a As shown in , the light emitting portion 220 may include multiple regions, and at least two of the multiple regions may be used to emit light of different wavelengths. Figure 2a The light emitting portion 220 shown in the figure may include a first region 221, a second region 222, and a third region 223, wherein, for example, the first region 221 and the second region 222 may be used to emit light of different wavelengths; the third region 223 may be used to emit light of a wavelength different from that of the first region 221 and the second region 222, or light of the same wavelength as that of one of the first region 221 and the second region 222. The lengths, areas, shapes, etc. of the multiple regions may be set to be the same or different. The multiple regions may be spaced apart or not spaced apart.

[0052] The multiple regions in the light emitting portion 220 may be distributed along at least one direction of the optical fiber body 210, so that the light emitting portion 220 can emit light in separate regions in at least one direction of the optical fiber body 210. In some embodiments, the at least one direction of the optical fiber body 210 may include at least one of the axial direction A, radial direction, and circumferential direction of the optical fiber body 210. For example, Figure 2aThe first region 221, the second region 222, and the third region 223 shown in the figure can be distributed along the axial direction A of the optical fiber body 210, so that the light emitting portion 220 can emit light in different regions in the axial direction A. The light emitting in different regions can be achieved by emitting light of different wavelengths in different regions. In other embodiments, the multiple regions can be distributed along the axial direction and / or the circumferential direction of the optical fiber body 210.

[0053] In other embodiments, the multiple regions may have a gradually changing transmittance, so that the multiple regions are used to emit light of gradually changing wavelengths. That is, every two adjacent regions in the multiple regions emit light of different wavelengths, and the transmittance of the multiple regions along at least one direction shows a gradually changing trend (for example, gradually increasing, gradually decreasing, gradually increasing and then decreasing, or gradually decreasing and then increasing), thereby achieving the effect of the light emitting portion 220 emitting light of gradually changing wavelengths. Figure 2a Taking the optical fiber 200 shown in as an example, the transmittance of the first area 221, the second area 222 and the third area 223 can be gradually increased or gradually decreased, or the transmittance of the second area 222 is greater than the transmittance of the first area 221 and the third area 223, or the transmittance of the second area 222 is less than the transmittance of the first area 221 and the third area 223. When the first area 221, the second area 222 and the third area 223 are adjacent, the light of continuously gradually changing wavelengths can be emitted. By setting multiple areas to emit light of gradually changing wavelengths (or wavelength bands), a gradual distribution of energy in the light-emitting portion can be achieved, which is conducive to ablation of heterogeneous lesions.

[0054] In some other embodiments, the light emission shapes of at least two of the multiple regions may be different, and the light emission shapes here may include emission such as diffuse light, side light, or annular light. Figure 2a For example, the first region 221 can be configured to emit annular light, the second region 222 can be configured to emit side-emitting light, and the third region 223 can be configured to emit diffuse light. In the disclosed embodiment, by separately configuring each region, different functions can be integrated into the same optical fiber, so as to be applicable to more application scenarios.

[0055] Figure 2b The optical fiber shown is Figure 2a The difference between the optical fibers shown in Figure 2bThe second area 222 of the multiple areas of the light emitting portion 220 shown in the figure can be a non-light emitting area, and the first area 221 and the third area 223 can be used to emit light of the same or different wavelengths. In other words, the first area 221 and the third area 223 can be arranged at intervals. It can be seen that when the multiple areas of the light emitting portion 220 include a non-light emitting area, the light emitting portion 220 can achieve regional light emitting by emitting light at intervals in at least one direction along the optical fiber body.

[0056] like Figure 2c As shown in , the multiple regions of the light-emitting portion 220 of the optical fiber 200 for laser ablation may include a first region 221 and a second region 222, wherein the first region 221 and the second region 222 may be used to emit light of different wavelengths; or the first region 221 is a light-emitting region, and the second region 222 is a non-light-emitting region. Figure 2c As further shown in FIG. 2 , in at least one direction along the optical fiber body 210, the first region 221 may be separated by the second region 222, so that the light emitting portion 220 may emit light in at least one direction in separate regions. In some embodiments, the wavelength of light emitted from the second region 222 may be smaller than the wavelength of light emitted from the first region 221.

[0057] The non-light emitting area mentioned above refers to an area where no light is emitted, which may be continuous or discontinuous; the light emitting area refers to an area used for emitting light (or light energy), which may be continuous or discontinuous. Here, continuous means that it may be uninterrupted, and discontinuous means that it may be intermittent. For example, taking the discontinuity of the first area 221 as an example, that is, the first area 221 may include a plurality of discontinuous sub-areas. Regardless of whether the first area 221 is continuous or discontinuous, and regardless of whether the second area 222 is a non-light emitting area, in at least one direction along the optical fiber body 210, since the first area 221 is separated by the second area 222, the light emitting portion 220 can achieve regional light emission by emitting light at intervals and / or emitting light of different wavelengths in the at least one direction.

[0058] In other embodiments, the light emitting portion 220 may emit light in divided regions in at least one direction, and may emit light in divided regions in the direction in which the first region 221 is separated by the second region 222. In the at least one direction, the sizes of the sub-regions into which the first region 221 is separated by the second region 222 may be the same or different.

[0059] Specifically, Figure 2cAs shown in , in the axial direction A along the optical fiber body 210, the first area 221 is separated by the second area 222, and can be separated into, for example, the first light-emitting section 2211 and the second light-emitting section 2212 shown in the figure, and the first light-emitting section and the second light-emitting section can be regarded as two sub-areas. The lengths of the first light-emitting section 2211 and the second light-emitting section 2212 (i.e., the extension length along the axial direction A) can be the same or different. In some embodiments, the first light-emitting section 2211 and the second light-emitting section 2212 can both surround the optical fiber body 210 once, so that the cross-sections of both are annular; or surround the optical fiber body 210 less than once, so that the cross-sections of both are arc-shaped. In other embodiments, the first light-emitting section 2211 and the second light-emitting section 2212 can be used to emit light of the same wavelength, or to emit light of different wavelengths. The first light-emitting section 2211 and the second light-emitting section 2212 can emit light at the same time, or at different times.

[0060] The wavelength range of light that can be emitted by the light emitting portion 220 can be achieved by setting its transmittance. For example, in some embodiments, the first light emitting section 2211 and the second light emitting section 2212 can both be used to emit light with a wavelength of 980nm, or can both be used to emit light with a wavelength of 1064nm. In other embodiments, one of the first light emitting section 2211 and the second light emitting section 2212 can be used to emit light with a wavelength of 980nm, and the other can be used to emit light with a wavelength of 1064nm. In some other embodiments, the second region 222 can emit light with a wavelength much smaller than that of the first region 221, such as light with a wavelength less than 355nm, or light with a wavelength less than 100nm.

[0061] Furthermore, if Figure 2d As shown in Figure 2c The difference between the optical fibers shown in Figure 2d The light exit portion 220 of the optical fiber 200 shown in the figure may further include a third region 223, which may be another light exit region. In some embodiments, the third region 223 may be adjacent to the first region 221, and may be used to emit light of the same or different wavelength as the first region 221. In still other embodiments, the second region 222 is used to emit light of a different wavelength from the first region 221, and the third region 223 may be used to emit light of the same or different wavelength from the second region 222.

[0062] Combination of the above Figure 2a-2dAn exemplary description of the optical fiber used for laser ablation according to the embodiment of the present disclosure is given. It can be understood that by setting the light-emitting portion of the optical fiber to multiple regions and emitting light of different wavelengths and / or emitting light at intervals, the light-emitting portion can emit light in different regions, which can effectively disperse the light energy and reduce the energy density, avoid the problem of central temperature energy concentration caused by traditional single-wavelength large-area light emission, and thus significantly reduce the risk of tissue burning caused by local high temperature. Furthermore, when irregularly shaped lesions need to be ablated using lasers of different wavelengths, if an optical fiber emitting a single wavelength of light is used, switching operations between multiple optical fibers (i.e., multiple plug-in and unplug operations) are required, while the optical fiber of the embodiment of the present disclosure can achieve the same optical fiber emitting light of different wavelengths, which can effectively reduce the number of plug-in and unplug operations on the optical fiber during the ablation operation, thereby greatly improving the convenience and safety of the ablation operation.

[0063] It can also be understood that from the above Figure 2b-2d It can be seen from the figure that when the multiple areas of the light emitting portion include a non-light emitting area, the non-light emitting area can be located between different light emitting areas or in one light emitting area, so as to separate the one light emitting area. Figure 2a-2d The optical fibers shown in the figure are exemplary and non-restrictive. For example, the number of multiple regions may not be limited to two or three as shown in the figure, and more may be set as needed. The number of light-emitting segments in a region may not be limited to two as shown in the figure, and more may be set as needed. Figure 3a-3d An exemplary description is given.

[0064] Figure 3a-3c A schematic diagram of an optical fiber including multiple light-emitting sections according to multiple embodiments of the present disclosure is shown; wherein, Figure 3a A schematic diagram showing an optical fiber including a plurality of light-emitting segments of equal length according to an embodiment of the present disclosure, Figure 3b A schematic diagram showing an optical fiber whose light-emitting section covers the end of the optical fiber according to an embodiment of the present disclosure, Figure 3c A schematic diagram showing an optical fiber including a plurality of light-emitting segments of different lengths according to an embodiment of the present disclosure.

[0065] like Figure 3a As shown in , in the axial direction A along the optical fiber body 210, the first region 221 can be divided into a plurality of light-emitting segments by the second region 222, such as the first light-emitting segment 2211, the second light-emitting segment 2212, the third light-emitting segment 2213, and the fourth light-emitting segment 2214 shown in the figure. In some embodiments, the lengths of the first light-emitting segment 2211, the second light-emitting segment 2212, the third light-emitting segment 2213, and the fourth light-emitting segment 2214 can be the same, and the spacings between adjacent light-emitting segments can be the same or different.

[0066] In some other embodiments, at least two of the plurality of light emitting segments can be used to emit light of different wavelengths. Figure 3a As shown in the example, for example, the first light exit section 2211 and the second light exit section 2212 can be used to emit light of different wavelengths, and the third light exit section 2213 and the fourth light exit section 2214 can be used to emit light of the same wavelength as the first light exit section 2211. For another example, the first light exit section 2211, the second light exit section 2212 and the third light exit section 2213 can be used to emit three different wavelengths of light, and the fourth light exit section 2214 can be used to emit light of the same wavelength as one of the three. For another example, the first light exit section 2211, the second light exit section 2212, the third light exit section 2213 and the fourth light exit section 2214 can be used to emit four different wavelengths of light.

[0067] In some other embodiments, two adjacent light emitting segments can be used to emit light of different wavelengths. Here, the adjacent light emitting segments may be two adjacent light emitting segments in the first region 221. For example, Figure 3a The first light emitting section 2211 and the third light emitting section 2213 shown in the figure can be used to emit light of a first wavelength, and the second light emitting section 2212 and the fourth light emitting section 2214 can be used to emit light of a second wavelength, and the first wavelength and the second wavelength are different. According to such a configuration, sequential light emission can be achieved, for example, the first light emitting section 2211 and the third light emitting section 2213 emit light of a first wavelength for the first time, and the second light emitting section 2212 and the fourth light emitting section 2214 do not emit light; the second light emitting section 2212 and the fourth light emitting section 2214 emit light of a second wavelength for the second time, and the first light emitting section 2211 and the third light emitting section 2213 do not emit light.

[0068] In some embodiments, the emission wavelengths and the order of the multiple light emission segments can be set according to the size, shape, properties, characteristics, etc. of the lesion to achieve conformal ablation of the lesion. Figure 3d An exemplary description is given. Figure 3d FIG. 1 is a schematic diagram showing a scenario in which the optical fiber of the disclosed embodiment is used to ablate a heterogeneous lesion. Figure 3d As shown in , the area at both ends of the heteromorphic lesion 301 is larger than the area in the middle region, and the area of ​​the heteromorphic lesion 301 can be adjusted by, for example, Figure 3a The optical fiber shown ablates the irregular lesion 301, and can do so by setting the first light output segment 2211 and the fourth light output segment 2214 to emit light of a larger wavelength, and setting the second light output segment 2212 and the third light output segment 2213 to emit light of a smaller wavelength. In this way, the light emitted by the light output segments at both ends can ablate a lesion area of ​​a larger area, and the light emitted by the light output segment in the middle can be used to ablate a lesion area of ​​a smaller area, thereby achieving ablation of the irregular lesion 301.

[0069] It is also worth noting that the present disclosure can also successfully eliminate the cooling step during laser ablation by adopting sequential light emission technology, which not only completely avoids the need for a cooling device, but also significantly reduces the size of the optical fiber catheter by eliminating the cooling channel design, making the operation more minimally invasive. This method makes it possible to efficiently complete the ablation task without refrigeration. In specific implementation, the first light emission segment 2211 and the third light emission segment 2213 can be emitted first, followed by the second light emission segment 2212 and the fourth light emission segment 2214, and then this sequence can be recycled. With the help of this orderly and time-difference light emission strategy, it is possible to effectively avoid excessive laser energy at the same position, ensuring the safety and efficiency of the ablation process.

[0070] In other embodiments, multiple light output segments can be used to simultaneously emit light of different wavelengths. It is understandable that multiple light output segments simultaneously or sequentially emit light of different wavelengths, which can be achieved by setting the transmittance of each light output segment. The ratio of the radiant energy projected and transmitted through an object to the total radiant energy projected onto the object is called the transmittance of the object. In the embodiments of the present disclosure, different light output segments can be coated with coatings of different transmittances, or the claddings of different light output segments are doped with different types of media or different density media, or the claddings of different light output segments are etched to different degrees, etc., so that the core transmission includes laser beams of multiple wavelengths, and beams of different wavelengths are emitted from light output segments of different transmittances, thereby achieving the effect of multiple light output segments emitting light of different wavelengths simultaneously.

[0071] Similarly, the above-mentioned method of sequentially emitting light can also be achieved by setting the transmittance of the light emitting segments at corresponding positions. When light of the first wavelength is transmitted in the fiber core, the first light emitting segment 2211 and the third light emitting segment 2213 emit light of the first wavelength, and the second light emitting segment 2212 and the fourth light emitting segment 2214 cannot transmit the light of the first wavelength, and thus do not emit light; when light of the second wavelength is transmitted in the fiber core, the second light emitting segment 2212 and the fourth light emitting segment 2214 emit light of the second wavelength, and the first light emitting segment 2211 and the third light emitting segment 2213 cannot transmit the light of the second wavelength, and thus do not emit light.

[0072] In some other embodiments, at least one of the multiple light emitting segments may have a gradual transmittance for emitting light of a gradual wavelength. The gradual transmittance may also be achieved by applying a gradual coating, or doping the cladding with different types of media or different density media, so as to achieve the purpose of emitting light of a gradual wavelength, which will not be described in detail here. The gradual change in this embodiment may be at least one of gradually increasing, or gradually decreasing, or gradually increasing and then decreasing, or gradually decreasing and then increasing, etc. By setting the light emitting segment to emit light of a gradual wavelength (or wavelength band), a gradual distribution of the energy of the light emitting segment can be achieved, which is also conducive to achieving ablation of heterogeneous lesions.

[0073] In some embodiments, at least two of the plurality of light emitting segments may have different light emitting shapes, where the light emitting shapes may include emitted light such as diffuse light, side light, or annular light. Figure 3a As an example, the first light-emitting segment 2211 can be set to emit annular light, the second light-emitting segment 2212 can be set to emit side-emitting light, and the third light-emitting segment 2213 and the fourth light-emitting segment 2214 can be set to emit diffuse light. Since the first area in the disclosed embodiment can be divided into multiple light-emitting segments, each light-emitting segment can be set separately to achieve the purpose of integrating different functions into the same optical fiber, so as to be applicable to more application scenarios.

[0074] Figure 3a The energy distribution 120 of the optical fiber when emitting light is further shown. Figure 3a As can be seen from the energy distribution 120 in FIG. 2 , dividing the first region 211 into multiple segments for separate light emission can effectively distribute the energy, avoid temperature superposition and excessive center temperature caused by concentrated energy density, and thus better control the energy output and reduce the total energy required for the ablation process. The reduction in total energy can help to extend the ablation time, thereby further expanding the ablation range and helping to achieve one-time ablation of a larger lesion. In addition, for the same ablation range, compared with, for example, Figure 1 The ablation optical fiber shown in the figure reduces the total energy required for ablation of the optical fiber in the embodiment of the disclosure, which is beneficial to reduce energy consumption and achieve energy saving.

[0075] Figure 3b The optical fiber shown in Figure 3a The difference between the optical fibers shown in Figure 3b The fourth light emitting section 2214 in the optical fiber can be located at the end of the optical fiber body 210, that is, it can cover the end of the optical fiber body 210 to achieve light emission at the end. Figure 3c The optical fiber shown in Figure 3a The difference between the optical fibers shown in Figure 3c The lengths of the multiple light-emitting segments shown in FIG. 2 are different. For example, the second light-emitting segment 2212 is longer, while the first light-emitting segment 2211 and the third light-emitting segment 2213 are shorter. Figure 3a-3c It can also be seen that the spacing between adjacent light-emitting segments in the plurality of light-emitting segments can be the same or different.

[0076] Combination of the above Figure 3a-3dAn exemplary description is given of an optical fiber having a plurality of light-emitting segments separated in the axial direction of the optical fiber body according to an embodiment of the present disclosure. It is to be understood that the above description is exemplary and not restrictive. For example, the number of light-emitting segments may not be limited to the four shown in the figure, and may be more or less as required. For another example, the plurality of light-emitting segments may not be limited to being separated in the axial direction of the optical fiber body, but may also be separated in other directions of the optical fiber body. Figure 4a-4f An exemplary description is given.

[0077] Figure 4a A schematic diagram of an optical fiber according to an embodiment of the present disclosure is shown in which a plurality of light-emitting segments are separated along the circumferential direction of the optical fiber body. Figure 4a As shown in , in the circumferential direction C along the optical fiber body 210, the first region can be divided into a plurality of light-emitting segments by the second region 222, such as the first light-emitting segment 2211 and the second light-emitting segment 2212 shown in the figure. In some embodiments, the first region is divided into a plurality of light-emitting segments in the circumferential direction C (i.e., the circumferential direction) of the optical fiber body 210, wherein the cross section of each light-emitting segment can be arc-shaped.

[0078] According to such a setting, it is helpful to reduce the difficulty of surgical puncture and realize the directionality of light emission. Figure 4b Provide further explanation. Figure 4b Shows Figure 4a Schematic diagram of an application scenario of optical fiber shown.

[0079] like Figure 4b As shown in , in some application scenarios, for example, when the lesion tissue is in a complex brain region, the surgical path may not pass through the center of the lesion region 402, or due to actual operation errors, the actual puncture path deviates from the center of the lesion region 402. In this case, if, for example, Figure 4a The optical fiber shown in can select light of a suitable wavelength for conformal ablation according to the distance from the optical fiber to the safe area 401 for lesion ablation. Figure 4b As shown in , the insertion position of the optical fiber is closer to the lower part of the lesion area 402, so that it is closer to the lower edge of the safety area 401, but farther from the upper edge of the safety area 401. At this time, the second light output segment 2212 close to the lower edge of the safety area 401 can be selected to emit light with a smaller wavelength, and the first light output segment 2211 toward the upper edge of the safety area 401 can be selected to emit light with a larger wavelength, so that smaller and larger lesion areas can be ablated at the same time.

[0080] In some other embodiments, assuming that the wavelength of the output light pre-set by the first light output segment 2211 in the figure is smaller than the wavelength of the output light of the second light output segment 2212, then after the distance of the optical fiber from the safe area 401 is determined during the operation, the optical fiber can be rotated so that the second light output segment 2212 capable of emitting light with a larger wavelength faces upward (i.e., toward the side farther from the edge of the safe area 401), and the first light output segment 2211 capable of emitting light with a smaller wavelength faces downward (i.e., toward the side closer to the edge of the safe area 401), so as to achieve the purpose of directionally selective light output, thereby achieving the effect of ablation while the surgical path deviates from the center of the lesion area.

[0081] Therefore, in the embodiment disclosed herein, the first area is divided into multiple light output segments along the circumferential direction C of the optical fiber body 210, and at least two of the multiple light output segments are used to emit light of different wavelengths. This can be used to solve the ablation problem when the surgical path is offset relative to the center of the lesion. There is no need to re-puncture and correct the surgical path, and there will be no risk of a larger lesion area being unable to be ablated at the same time due to the offset, or a smaller lesion area being subject to the risk of over-ablation or burning.

[0082] Figure 4c A schematic diagram of an optical fiber according to an embodiment of the present disclosure is shown in which a plurality of light-emitting segments are symmetrically distributed along the circumferential direction of the optical fiber body. Figure 4d Shows Figure 4c The cross-sectional diagram of the optical fiber is shown in FIG. Figure 4c and Figure 4d As shown in , in the circumferential direction C along the optical fiber body 210, the first region can be divided into a plurality of light-emitting segments by the second region 222, such as the first light-emitting segment 2211, the second light-emitting segment 2212, the third light-emitting segment 2213 and the fourth light-emitting segment 2214 shown in the figure. The plurality of light-emitting segments can be symmetrically distributed with the central axis of the optical fiber body 210 (i.e., the axis passing through the center of the optical fiber cross section) as the center. Symmetrical distribution means that when one of the two light-emitting segments rotates 180 degrees around the center, it can completely overlap with the other of the two light-emitting segments.

[0083] In some embodiments, at least one pair of two mutually symmetrical light emitting segments among the plurality of light emitting segments can be used to emit light of different wavelengths. For example, in some embodiments, the first light emitting segment 2211 and the second light emitting segment 2212 can be used to emit light of different wavelengths; the third light emitting segment 2213 and the fourth light emitting segment 2214 can be used to emit light of the same wavelength, and the wavelength of the light emitted by the first light emitting segment 2211 or the second light emitting segment 2212 can be the same as or different from that of the light emitted by the first light emitting segment 2211 or the second light emitting segment 2212. In other embodiments, the symmetrical first light emitting segment 2211 and the second light emitting segment 2212 are used to emit light of different wavelengths; and the symmetrical third light emitting segment 2213 and the fourth light emitting segment 2214 are also used to emit light of different wavelengths.

[0084] In the above embodiments, by setting each pair of light output segments in at least two pairs of mutually symmetrical light output segments to emit light of different wavelengths, it is possible to solve not only the ablation problem when the surgical path is offset relative to the center of the lesion area in one direction (for example, the up and down directions), but also the ablation problem when the surgical path is offset relative to the center of the lesion area in at least two directions.

[0085] Figure 4e A schematic diagram of an optical fiber according to an embodiment of the present disclosure is shown in which a plurality of light-emitting segments are evenly distributed along the circumferential direction of the optical fiber body. Figure 4f Shows Figure 4e The cross-sectional diagram of the optical fiber is shown in FIG. Figure 4e and Figure 4f As shown in , in the circumferential direction C along the optical fiber body 210, the first area can be divided into a plurality of light emitting segments by the second area 222, such as the first light emitting segment 2211, the second light emitting segment 2212 and the third light emitting segment 2213 shown in the figure. The plurality of light emitting segments can be evenly distributed with the central axis of the optical fiber body 210 as the center. Even distribution means that the spacing between each two adjacent light emitting segments is the same. The plurality of light emitting segments can be used to emit light of the same wavelength, or at least two of the light emitting segments are used to emit light of different wavelengths. Since the evenly distributed plurality of light emitting segments are also facing different directions, they can also be used for ablation of irregular lesions or situations where the surgical path deviates from the center of the lesion.

[0086] Combination of the above Figure 4a-4f An exemplary description is given of an optical fiber including a plurality of light output segments distributed along the circumferential direction of the optical fiber body. It can be understood that when a plurality of regions of the light output portion are distributed along the circumferential direction of the optical fiber body, and at least two of the plurality of regions are used to emit light of different wavelengths, regardless of whether there are non-light output regions in the plurality of regions, a technical effect similar to the circumferential distribution of the above-mentioned plurality of light output segments can be achieved, and will not be repeated here.

[0087] It can also be understood that the above description is exemplary and not restrictive. For example, the number of light output segments obtained by separation along the circumferential direction of the optical fiber body may not be limited to the two, three, or four shown in the figure, and may be more as needed. For another example, the multiple light output segments may not be limited to the uniform distribution or symmetrical distribution described above, and may also be set to other regular or irregular distribution methods as needed, and the sizes of the multiple light output segments may also be set to be the same or different as needed. For another example, the optical fiber of the embodiment of the present disclosure may not be limited to the multiple light output segments separated only in the circumferential direction or the axial direction as described above, and may also be separated in at least two directions. The following will be combined with Figure 5a and Figure 5b An exemplary description is given.

[0088] Figure 5a Schematic diagram of an optical fiber with multiple light-emitting segments separated in the circumferential direction and axial direction of the optical fiber body according to some embodiments of the present disclosure is shown. Figure 5a As shown in the figure, in the axial direction A and the circumferential direction C along the optical fiber body 210, the first region 221 can be divided into multiple light output segments by the second region 222, such as the first light output segment 2211, the second light output segment 2212, the third light output segment 2213, the fourth light output segment 2214, the fifth light output segment 2215 and the sixth light output segment 2216 shown in the figure.

[0089] In some embodiments, a portion of the plurality of light-emitting segments is distributed along the circumferential direction C of the optical fiber body 210, and another portion of the plurality of light-emitting segments is distributed along the axial direction A. Figure 5a As shown in the figure, the fifth light output segment 2215 and the sixth light output segment 2216 among the multiple light output segments are distributed on the optical fiber body 210 along the circumferential direction C of the optical fiber body 210, and the first light output segment 2211, the second light output segment 2212, the third light output segment 2213 and the fourth light output segment 2214 among the multiple light output segments are distributed along the axial direction A of the optical fiber body 210.

[0090] Figure 5b Schematic diagrams of optical fibers with multiple light-emitting segments separated along the circumferential direction and axial direction of the optical fiber body according to other embodiments of the present disclosure are shown. Figure 5bAs shown in , along the axial direction A and the circumferential direction C of the optical fiber body 210, the first region 221 can be divided into a plurality of light-emitting segments by the second region 222, such as the first light-emitting segment 2211, the second light-emitting segment 2212, the third light-emitting segment 2213, the fourth light-emitting segment 2214, the fifth light-emitting segment 2215, the sixth light-emitting segment 2216, the seventh light-emitting segment 2217 and the eighth light-emitting segment 2218 shown in the figure. The fifth light-emitting segment 2215 and the sixth light-emitting segment 2216 of the plurality of light-emitting segments are distributed on the optical fiber body 210 along the circumferential direction C of the optical fiber body 210, the fourth light-emitting segment 2214, the seventh light-emitting segment 2217 and the eighth light-emitting segment 2218 are distributed on the optical fiber body 210 along the circumferential direction C of the optical fiber body 210, and the first light-emitting segment 2211, the second light-emitting segment 2212 and the third light-emitting segment 2213 are distributed along the axial direction A of the optical fiber body 210.

[0091] Combination of the above Figure 5a and Figure 5b The disclosed embodiment provides an exemplary description of an optical fiber having a plurality of light-emitting segments separated in the circumferential direction and the axial direction of the optical fiber body. It is understandable that the plurality of light-emitting segments can be used to emit light of the same wavelength, or at least two of the light-emitting segments are used to emit light of different wavelengths. By separating the plurality of light-emitting segments in multiple directions along the optical fiber body, or distributing the plurality of regions of the light-emitting portion in multiple directions along the optical fiber body, the optical fiber can be used not only for ablation of irregular lesions, but also for ablation when the surgical path deviates from the center of the lesion.

[0092] Figure 6a A schematic diagram of an optical fiber including a plurality of light output blocks according to some embodiments of the present disclosure is shown. Figure 6a As shown in , in the axial direction A along the optical fiber body 210, the first region 221 can be separated into a plurality of light emitting segments by the second region 222, such as the first light emitting segment 2211, the second light emitting segment 2212 and the third light emitting segment 2213 shown in the figure, wherein at least one of the plurality of light emitting segments may include a plurality of light emitting blocks, for example, the first light emitting segment 2211 shown in the figure may include a plurality of light emitting blocks 601. The sizes of the plurality of light emitting blocks 601 may be the same or different. The plurality of light emitting blocks 601 may be separated by the second region 222. Therefore, the plurality of light emitting blocks 601 may also be regarded as being separated by the non-light emitting region 222 in at least one direction of the optical fiber body 210. In other embodiments, the plurality of light emitting blocks 601 may not be separated.

[0093] In some embodiments, the plurality of light output blocks 601 may be distributed in an array. The array distribution here may include, for example, one or more array forms such as 1×n, m×1, and m×n, where m and n are both positive integers greater than 1. It is understood that the optical fiber of the disclosed embodiment is not limited to having only one light output section including a plurality of light output blocks, but may also have a plurality of light output sections each including a plurality of light output blocks. Figure 6b An exemplary description is given.

[0094] Figure 6b Schematic diagrams showing optical fibers including multiple light output blocks according to other embodiments of the present disclosure. Figure 6b As shown in , the first area 221 can be divided into a plurality of light emitting blocks 601 by the second area 222, which is equivalent to each light emitting segment including a plurality of light emitting blocks 601, thereby forming an array of light emitting blocks 601 as shown in the figure.

[0095] Combination of the above Figure 6a and Figure 6b An optical fiber including a plurality of light output blocks according to an embodiment of the present disclosure is exemplarily described. It can be understood that by dividing the first area more finely into a plurality of light output blocks, the energy distribution is more uniform, and it is easier to achieve control over the type, wavelength, range, energy, etc. of the output light, and it is also easier to achieve more accurate conformal ablation according to the size, properties, tissue properties, etc. of the lesion. In other embodiments, at least two of the plurality of light output blocks can be used to emit light of different wavelengths. Similarly, the plurality of regions of the light output portion can also be distributed in an array in a block form to achieve the same or similar technical effect as the aforementioned distribution of the plurality of light output blocks.

[0096] It can also be understood that the above description is exemplary rather than restrictive. For example, the first area may not be limited to being divided into the light-emitting segments or light-emitting blocks described above. In some other embodiments, the first area may be continuous and emit light at intervals. For ease of understanding, an exemplary description will be given below in conjunction with FIG. 7 .

[0097] Figure 7a FIG. 1 is a schematic diagram showing a helical optical fiber in the first region according to an embodiment of the present disclosure. Figure 7a As shown in the figure, the first region 221 of the optical fiber can be spirally wound around the optical fiber body 210, and the second region 222 is formed between the spiral first regions 221. The region between the two adjacent spiral teeth is the region between the spiral first regions 221. The second region 222 formed in this way is also spiral. In this embodiment, the pitch of the spiral first region 221 can be equal to the width of the second region 222, which can be set to be uniform (for example, Figure 7a ), it can also be set to be gradual (e.g., gradually widening or narrowing). For example, Figure 7bSchematic diagram of an optical fiber with a gradual pitch change in the helical first region according to an embodiment of the present disclosure. Figure 7b As shown in FIG. 2 , along the F direction in the figure, the pitch of the spiral first region 221 gradually narrows (that is, the width of the second region 222 gradually narrows).

[0098] In some embodiments, the spiral first region 221 may be continuous. In other embodiments, the spiral first region 221 may also be divided into a plurality of spiral light-emitting segments, or the light-emitting portion of the disclosed embodiment may include a plurality of spiral regions. In still other embodiments, at least two of the plurality of spiral light-emitting segments may be used to emit light of different wavelengths.

[0099] In other embodiments, the spiral first region 221 may have a gradually changing transmittance along its spiral extension direction, so as to emit light of gradually changing wavelengths. The spiral extension direction of the first region 221 may be the rotation direction of the first region 221 on the optical fiber body 210. In still other embodiments, at least one of the plurality of spiral light emitting segments may be used to emit light of gradually changing wavelengths. The implementation methods of gradually changing transmittance and gradually changing wavelength have been described in the previous text in conjunction with Figure 3a It has been explained and will not be repeated here.

[0100] It is understandable that by setting the first region 221 in a spiral shape, the first region 221 can be divided at least in the axial direction of the optical fiber body 210, so that the light can be emitted in different regions. It is also understandable that the above description is exemplary and not restrictive. For example, in some embodiments, a part of the first region 221 can be set in a spiral shape, and another part can be set in a complete light emitting section or divided into a plurality of light emitting sections.

[0101] The present disclosure also provides a laser ablation system in another aspect, comprising: Figure 2a-Figure 7b In some other embodiments, the laser ablation system may further include one or more lasers. In some embodiments, a laser may emit laser light of one or more wavelengths. In some other embodiments, the laser ablation system may include multiple lasers, each of which may emit laser light of a single wavelength. The optical fiber according to the embodiment of the present disclosure may cooperate with the one or more lasers to emit light of corresponding wavelengths.

[0102] In summary, according to the optical fiber for laser ablation of the embodiment of the present disclosure, the light emitting portion can be set to multiple regions in at least one direction of the optical fiber body, and the light emitting portion can be realized by separately setting each region, so that the optical fiber of the embodiment of the present disclosure has the characteristics of uniform energy transfer and energy distribution, which is conducive to avoiding the risk of burning caused by central heat concentration. In some embodiments, by setting the regional light emission (for example, at least two light emission segments, or at least two regions) to emit light of different wavelengths, or setting at least one light emission segment to emit light of gradually changing wavelengths, the same optical fiber can be used to emit light of different wavelengths, so that it can be more suitable for the needs of multiple scenes, and can selectively emit light of appropriate wavelengths according to the size, properties, etc. of the lesion to achieve conformal ablation.

[0103] Furthermore, according to the optical fiber including multiple regions of the embodiment of the present disclosure, a suitable light output mode can be selected according to the specific conditions of the diseased tissue. For example, the shape, size and other properties of the diseased tissue can be adapted by setting multiple regions to emit light beams of different wavelengths and shapes (such as diffuse light, side light, annular light, etc.), or outputting light beams of gradually changing wavelengths. For example, the timely and directional light output can be selected according to the positional relationship between the light output portion of the optical fiber and the diseased tissue. Therefore, the optical fiber according to the embodiment of the present disclosure is not only conducive to improving the accuracy of treatment, but also conducive to improving the adaptability and flexibility of the treatment plan, providing more targeted, personalized and accurate support for laser ablation treatment.

[0104] Although multiple embodiments of the present disclosure have been shown and described herein, it will be apparent to those skilled in the art that such embodiments are provided by way of example only. Those skilled in the art may think of many changes, modifications, and alternatives without departing from the thought and spirit of the present disclosure. It should be understood that in the process of practicing the present disclosure, various alternatives to the embodiments of the present disclosure described herein may be adopted. The attached claims are intended to define the scope of protection of the present disclosure, and therefore cover equivalents or alternatives within the scope of these claims.

Claims

1. An optical fiber for laser ablation, comprising: An optical fiber body, which has a light-emitting portion, the light-emitting portion being close to one end of the optical fiber body; in The light emitting portion includes a plurality of regions, at least two of the plurality of regions are used to emit light of different wavelengths, and / or the plurality of regions include a non-light emitting region, so that the light emitting portion can emit light in separate regions in at least one direction along the optical fiber body.

2. The optical fiber according to claim 1, wherein the light-emitting portion comprises a first region and a second region, wherein the first region and the second region are used to emit light of different wavelengths; or the first region is a light-emitting region, and the second region is a non-light-emitting region; In at least one direction along the optical fiber body, the first region is separated by the second region, so that the light emitting portion can emit light in divided regions in the at least one direction.

3. The optical fiber according to claim 2, wherein the wavelength of the light emitted from the second region is smaller than the wavelength of the light emitted from the first region.

4. The optical fiber according to claim 2 or 3, wherein: In at least the axial direction and / or the circumferential direction along the optical fiber body, the first region is divided into a plurality of light-emitting segments by the second region.

5. The optical fiber according to claim 4, wherein At least two of the plurality of light emitting segments are used to emit light of different wavelengths.

6. The optical fiber according to claim 4 or 5, wherein In the axial direction of the optical fiber body, the first region is divided into a plurality of light-emitting segments by the second region, wherein two adjacent light-emitting segments are used for emitting light of different wavelengths.

7. The optical fiber according to claim 4 or 5, wherein In the circumferential direction along the optical fiber body, the first region is divided into a plurality of light-emitting segments by the second region, and the plurality of light-emitting segments are symmetrically or evenly distributed with the central axis of the optical fiber body as the center.

8. The optical fiber according to claim 7, wherein The plurality of light emitting segments are symmetrically distributed around the center, wherein at least one pair of two mutually symmetrical light emitting segments are used for emitting light of different wavelengths.

9. The optical fiber according to claim 4 or 5, wherein In the axial direction and the circumferential direction along the optical fiber body, the first region is divided into a plurality of light-emitting segments by the second region, wherein a portion of the plurality of light-emitting segments are distributed along the circumferential direction, and another portion of the plurality of light-emitting segments are distributed along the axial direction.

10. The optical fiber according to any one of claims 4 to 9, wherein At least one of the plurality of light emitting segments comprises a plurality of light emitting blocks, and the plurality of light emitting blocks are distributed in an array.

11. The optical fiber according to claim 10, wherein at least two light output blocks among the plurality of light output blocks are used to output light of different wavelengths.

12. The optical fiber according to any one of claims 4 to 11, wherein at least one of the plurality of light-emitting segments has a gradually varying transmittance for emitting light of gradually varying wavelengths.

13. The optical fiber according to claim 1, wherein the plurality of regions have a graded transmittance, so that the plurality of regions are used to emit light of graded wavelengths.

14. The optical fiber according to any one of claims 4-11, wherein at least two of the multiple light-emitting segments have different light-emitting shapes, and the light-emitting shapes include emitted diffuse light, side-emitting light, or annular light.

15. The optical fiber according to claim 1, wherein light output shapes of at least two of the plurality of regions are different, and the light output shapes include output diffuse light, side light, or annular light.

16. The optical fiber according to claim 2, wherein At least a portion of the first region is spirally wound around the optical fiber body, and the second region is formed between the spiral first regions. 17 . The optical fiber according to claim 16 , wherein the helical first region has a gradually changing transmittance along its helical extension direction so as to emit light of gradually changing wavelengths.

18. The optical fiber according to claim 1, wherein at least two of the plurality of regions are used to emit light having a wavelength of 980 nm and light having a wavelength of 1064 nm, respectively.

19. A laser ablation system, comprising the optical fiber according to any one of claims 1-18.

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