A method and system for automatic regulation of body temperature in continuity

Abstract

The application provides a continuous body temperature automatic regulation method and system. The method comprises the following steps: collecting the temperature of the arterial side and the temperature of the venous side in the extracorporeal circulation blood pipeline, compensating the heat loss of the pipeline to obtain the arterial blood temperature at the fistula and the venous blood temperature at the fistula; measuring the recirculation percentage of the blood vessel access, calculating the initial central body temperature based on the arterial blood temperature at the fistula, the venous blood temperature at the fistula and the recirculation percentage; taking the initial central body temperature as the target central body temperature, calculating the target venous blood temperature at the fistula; compensating the heat loss of the pipeline to the target venous blood temperature at the fistula to obtain the target dialysate temperature; and controlling the dialysate temperature to stabilize at the target dialysate temperature. The method improves the accuracy of the calculation of the central body temperature of the patient, can automatically control the central body temperature of the patient, does not need human control, and can adapt to the individual differences of the initial body temperature of different patient groups.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of hemodialysis, in particular to a continuous body temperature automatic regulation method and system. BACKGROUND

[0002] Body temperature is an important physiological index in the process of hemodialysis, and if the body temperature of the patient is raised or lowered too fast during the treatment, it will bring discomfort and harm to the patient. During the hemodialysis process, the patient will generally have a rise in body temperature due to the generation of endogenous heat, which is obviously not conducive to the treatment of the patient. To solve this problem, the dialyzer is currently used as a heat exchange place for blood and dialysate during treatment, and the patient's body temperature is indirectly regulated by adjusting the temperature of the dialysate. Mainly: before treatment, medical staff can measure the patient's body temperature using a thermometer, and set an appropriate dialysate temperature during treatment. A constant dialysate temperature (such as 37℃) is used during the treatment, or a pre-set dialysate temperature variation curve is used, that is, the dialysate temperature is automatically adjusted according to the curve variation law over time.

[0003] However, the existing regulation method generally has the following problems:

[0004] 1. Manual measurement of body temperature increases unnecessary steps and labor costs.

[0005] 2. The patient's body temperature is often not a fixed value, and the pre-set dialysate temperature cannot be selectively treated according to the individual differences in the patient's body temperature. SUMMARY

[0006] In order to overcome the defects in the prior art, the purpose of the present application is to provide a continuous body temperature automatic regulation method and system.

[0007] In order to achieve the above-mentioned purpose of the present application, the present application provides a continuous body temperature automatic regulation method, comprising the following steps:

[0008] During the dialysis stage, the arterial side temperature and the venous side temperature in the extracorporeal circulation blood pipeline are collected in real time, the arterial side temperature and the venous side temperature are compensated for pipeline heat loss to obtain the arterial blood temperature at the fistula and the venous blood temperature at the fistula, and the arterial-venous blood temperature curve is generated according to the arterial blood temperature at the fistula and the venous blood temperature at the fistula;

[0009] The recirculation percentage of the blood vessel access is measured periodically, and the initial central body temperature is calculated based on the arterial blood temperature at the fistula, the venous blood temperature at the fistula, and the recirculation percentage;

[0010] The initial central body temperature is taken as the target central body temperature, and the target venous blood temperature at the fistula is calculated;

[0011] The target venous blood temperature at the fistula is compensated for pipeline heat loss to obtain the target temperature of the dialysate;

[0012] Controlling the dialysate temperature to stabilize at a dialysate target temperature.

[0013] The method considers the influence of vascular access recirculation on body temperature measurement, improves the accuracy of calculation of the central body temperature of the patient, can automatically control the central body temperature of the patient, does not need human control, and can adapt to individual differences in initial body temperature of different patient groups.

[0014] In an optional scheme of the continuous body temperature automatic regulation method, the initial central body temperature Wherein, T art0 is the initial arterial blood temperature at the fistula; T ven0 is the initial venous blood temperature at the fistula, and R0 is the initial measured recirculation percentage;

[0015] The target venous blood temperature at the fistula is T Wherein, T art is the real-time arterial blood temperature at the fistula, R is the recirculation percentage, [t1, t2] refers to the pulse integral interval on the arterial-venous blood temperature curve when the recirculation percentage is measured, T art (t) refers to the arterial blood temperature at the fistula at t on the arterial-venous blood temperature curve, and T ven (t) refers to the venous blood temperature at the fistula at t on the arterial-venous blood temperature curve.

[0016] In an optional scheme of the continuous body temperature automatic regulation method, the measurement step of the recirculation percentage R is:

[0017] Generating an arterial-venous blood temperature curve according to the arterial blood temperature at the fistula and the venous blood temperature at the fistula;

[0018] Pushing a temperature change pulse to the artery and vein through the dialysate, and calculating the recirculation percentage according to the stress pulse part generated by the temperature change pulse on the arterial-venous blood temperature curve.

[0019] In an optional scheme of the continuous body temperature automatic regulation method, setting a target central body temperature change trend before or during dialysis, and generating a target central body temperature change curve according to the initial central body temperature and the target central body temperature change trend;

[0020] Real-time acquisition of the arterial side temperature and the venous side temperature in the extracorporeal circulation blood pipeline during dialysis;

[0021] Calculating the target venous blood temperature at the fistula at t according to the target central body temperature curve during dialysis;

[0022] Compensating the target venous blood temperature at the fistula at t for pipeline heat loss to obtain the dialysate target temperature at t.

[0023] The optional scheme continuously measures the body temperature of the patient on the basis of the original scheme, so that the blood temperature of the patient during the hemodialysis process is consistent with the temperature on the target central body temperature curve, and is particularly suitable for the population with initial blood temperature that is too low or too high.

[0024] In an optional scheme of the continuous body temperature automatic adjustment method, the target venous blood temperature at the fistula at time t is Wherein, T bt is the target central body temperature at time t on the target central body temperature curve, and T artt is the arterial blood temperature at time t.

[0025] In an optional scheme of the continuous body temperature automatic adjustment method, the upper limit and the lower limit of the dialysate temperature are set, when the target temperature of the dialysate is higher than the upper limit of the dialysate temperature, the upper limit of the dialysate temperature is taken as the target temperature of the dialysate, and when the target temperature of the dialysate is lower than the lower limit of the dialysate temperature, the lower limit of the dialysate temperature is taken as the target temperature of the dialysate.

[0026] The optional scheme ensures that the body temperature of the patient during the hemodialysis process is automatically adjusted within a safe range.

[0027] The application further provides a continuous body temperature automatic adjustment system, which comprises a dialysate temperature controller, an arterial temperature sensor for collecting the temperature on the arterial side of the extracorporeal circulation blood pipeline, and a venous temperature sensor for collecting the temperature on the venous side of the extracorporeal circulation blood pipeline.

[0028] The signal output ends of the arterial temperature sensor and the venous temperature sensor are connected with the corresponding signal input ends of the dialysate temperature controller, respectively; the dialysate temperature controller calculates the target temperature of the dialysate based on the arterial side temperature and the venous side temperature according to the above-mentioned continuous body temperature automatic adjustment method, and adjusts the temperature of the dialysate with the target temperature of the dialysate.

[0029] In an optional scheme of the continuous body temperature automatic adjustment system, a heating module is further included, the heating module is in control connection with the dialysate temperature controller, and the dialysate temperature controller controls the heating module to heat the dialysate, so that the temperature of the dialysate is consistent with the target temperature of the dialysate.

[0030] The application has the following beneficial effects: the application continuously measures the body temperature of the patient, considers the influence of the recirculation of the blood vessel access on the body temperature measurement, improves the accuracy of the calculation of the central body temperature of the patient, can automatically control the central body temperature of the patient, does not need to be measured and controlled artificially, can adapt to the individual differences of the initial body temperature of different patient populations, measures the body temperature of the patient in real time during the hemodialysis process and automatically adjusts the body temperature of the patient within a safe range, so that the body temperature of the patient reaches or maintains around the expected target after the treatment.

[0031] Additional aspects and advantages of the present application will be made apparent by the following description and the accompanying drawings. BRIEF DESCRIPTION OF DRAWINGS

[0032] The above and / or additional aspects and advantages of the present application will become apparent and be readily understood by considering the following detailed description, including the accompanying drawings, in which:

[0033] Figure 1 is an installation schematic diagram of an arterial temperature sensor and a venous temperature sensor. DETAILED DESCRIPTION

[0034] Embodiments of the present application are described below in detail with reference to the accompanying drawings, in which the same or similar elements or elements having the same or similar functions are denoted by the same reference numerals throughout. The embodiments described below by reference to the accompanying drawings are exemplary and are intended only for explanation of the present application, and should not be construed as limiting the present application.

[0035] In the description of the present application, unless otherwise specified and limited, it is necessary to explain that the terms "installation", "connection", "connection" should be understood broadly, for example, it can be mechanical connection or electrical connection, it can be internal communication of two elements, it can be direct connection or indirect connection through intermediate medium, and the specific meaning of the above terms can be understood by those skilled in the art according to the specific circumstances.

[0036] Example one

[0037] The present application provides a continuous body temperature automatic regulation method, which is particularly suitable for the field of hemodialysis. Specifically, it comprises the following steps:

[0038] As shown in Figure 1 , an arterial temperature sensor for collecting arterial side temperature is arranged on the arterial side of the extracorporeal blood circuit, and a venous temperature sensor for collecting venous side temperature is arranged on the venous side of the extracorporeal blood circuit.

[0039] In the dialysis stage, the arterial side temperature and the venous side temperature in the extracorporeal blood circuit are collected in real time, and the arterial side temperature and the venous side temperature are compensated for heat loss in the pipeline to obtain the arterial blood temperature at the fistula and the venous blood temperature at the fistula. Specifically as follows:

[0040]

[0041] Wherein, T art is the real-time arterial blood temperature at the fistula, T ven is the real-time venous blood temperature at the fistula, T art ′ is the arterial side temperature, T ven ′ is the venous side temperature, C artC is the temperature loss compensation value of the arterial blood line from the fistula to the arterial temperature sensor, ven C is the temperature loss compensation value of the venous blood line from the venous temperature sensor to the fistula, art and C ven The value of can be determined based on factors such as the tube material, tube length, and blood flow in the tube.

[0042] The percentage of vascular access recirculation was measured regularly.

[0043] The vascular access recirculation percentage can be measured using existing known methods. In this embodiment, the following method is used:

[0044] An arteriovenous blood temperature curve is generated based on the arterial blood temperature and venous blood temperature at the fistula site.

[0045] Based on the known principle of thermodilution, recirculation measurement is performed non-invasively: a short temperature change pulse is actively generated on the dialysate side, such as a temperature change pulse of about 2.5°C. That is, if the current temperature rises or falls by 2.5°C, the arteriovenous blood temperature curve will generate a stress pulse. The recirculation percentage is calculated based on the stress pulse generated by the arteriovenous blood temperature curve. The calculation formula is as follows:

[0046]

[0047] Among them, [t1, t2] refers to the pulse integration interval on the arteriovenous blood temperature curve when measuring the recirculation percentage, which is set manually. art (t) refers to the arterial blood temperature at the fistula at time t on the arteriovenous blood temperature curve, T ven (t) refers to the fistula venous blood temperature at time t on the arteriovenous blood temperature curve. The initial central body temperature is calculated based on the fistula arterial blood temperature, fistula venous blood temperature, and recirculation percentage. The calculation formula is as follows:

[0048]

[0049] Among them, T b is the initial central body temperature, T art0 T is the initial arterial blood temperature at the fistula site; ven0 is the initial venous blood temperature at the fistula site, and R0 is the recirculation percentage measured initially.

[0050] The initial central body temperature is used as the target central body temperature to calculate the target venous blood temperature at the fistula. The formula for calculating the target venous blood temperature at the fistula is as follows:

[0051]

[0052] R is the recirculation percentage, which is measured at the set measurement frequency. Each time the target venous blood temperature at the fistula is calculated, the most recent recirculation percentage is used. If the recirculation percentage is measured only once during the entire dialysis process, the initial recirculation percentage (R0) is used for all calculations.

[0053] The target venous blood temperature at the fistula is compensated for the heat loss in the pipeline to obtain the target dialysate temperature, that is, the dialysate target temperature T dial =T ven ″+C ven .

[0054] To ensure safety, set the upper and lower limits of the dialysate temperature. When the dialysate target temperature is higher than the upper limit, the upper limit is used as the dialysate target temperature. When the dialysate target temperature is lower than the lower limit, the lower limit is used as the dialysate target temperature. For example, setting 35°C as the lower limit and 38°C as the upper limit yields:

[0055]

[0056] The dialysate temperature is then controlled to stabilize it at the dialysate target temperature, ensuring that the patient's blood temperature is continuously maintained at the initial central body temperature T during the dialysis process. b .

[0057] Example 2

[0058] This embodiment is the same as the first embodiment, in that an arterial temperature sensor for collecting the arterial temperature is provided on the arterial side of the extracorporeal blood circulation line, and a venous temperature sensor for collecting the venous temperature is provided on the venous side of the extracorporeal blood circulation line.

[0059] The target central body temperature change trend is set before the start of dialysis or during dialysis, and a target central body temperature change curve is generated according to the initial central body temperature and the target central body temperature change trend.

[0060] During dialysis, the arterial and venous temperatures of the extracorporeal blood circuit are collected in real time, and the arterial and venous temperatures are compensated for heat loss in the circuit to obtain the arterial and venous blood temperatures at the fistula.

[0061] During dialysis, the target venous blood temperature at the fistula at time t was calculated based on the target central body temperature curve;

[0062] Target venous blood temperature at fistula at time t Among them, T bt is the target central body temperature at time t on the target central body temperature curve, T artt is the arterial blood temperature at the fistula at time t, T artt =Tartt ′ + C art , T artt ′ is the arterial temperature at time t.

[0063] The target temperature of dialysate at time t is obtained by compensating the heat loss of the pipeline for the target venous blood temperature at the fistula at time t, i.e., the target temperature of dialysate at time t T dialt = T ven ″ t + C ven .

[0064] To ensure safety, the upper and lower limits of the temperature of dialysate can also be set as in Embodiment One, and when the target temperature of dialysate is higher than the upper limit of the temperature of dialysate, the upper limit of the temperature of dialysate is taken as the target temperature of dialysate; and when the target temperature of dialysate is lower than the lower limit of the temperature of dialysate, the lower limit of the temperature of dialysate is taken as the target temperature of dialysate. For example, 35℃ is taken as the lower limit of the temperature of dialysate, and 38℃ is taken as the upper limit of the temperature of dialysate, so that:

[0065]

[0066] Then the temperature of dialysate is controlled to change with the target central body temperature curve, so as to ensure that the blood temperature of the patient during dialysis is consistent with the temperature on the target central body temperature curve.

[0067] Embodiment Three

[0068] The embodiment also provides a continuous body temperature automatic adjustment system, which comprises a dialysate temperature controller, an arterial temperature sensor for collecting the arterial temperature of the extracorporeal circulation blood pipeline, a venous temperature sensor for collecting the venous temperature of the extracorporeal circulation blood pipeline, and a heating module. The signal output ends of the arterial temperature sensor and the venous temperature sensor are connected to the corresponding signal input ends of the dialysate temperature controller, and the heating module is in control connection with the dialysate temperature controller.

[0069] The dialysate temperature controller calculates the target temperature of dialysate according to the continuous body temperature automatic adjustment method of Embodiment One or Embodiment Two based on the arterial temperature and the venous temperature, and controls the heating module to heat the dialysate with the target temperature of dialysate as the target, so as to make the temperature of dialysate consistent with the target temperature of dialysate, and to realize the adjustment of the temperature of dialysate.

[0070] A dialysate temperature sensor can be arranged to collect the temperature of dialysate, so as to confirm whether the temperature of dialysate is consistent with the target temperature of dialysate, and the signal output end of the dialysate temperature sensor is connected to the corresponding signal input end of the dialysate temperature controller.

[0071] In the description of the specification, reference to "one embodiment", "some embodiments", "an example", "a specific example", or "some examples" means that a particular feature, structure, material, or characteristic being described is included in at least one embodiment or example of the application. The appearances of the above expressions in various places in the specification are not necessarily referring to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics can be combined in any suitable manner in one or more embodiments or examples.

[0072] Although embodiments of the application have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions, and alterations can be made hereto without departing from the spirit and scope of the application, which is defined by the following claims and their equivalents.

Claims

1. A continuous body temperature automatic regulation system, characterized in that: It includes a dialysate temperature controller, an arterial temperature sensor for collecting the temperature on the arterial side of the extracorporeal blood circuit, and a venous temperature sensor for collecting the temperature on the venous side; The signal output ends of the arterial temperature sensor and the venous temperature sensor are respectively connected to the corresponding signal input ends of the dialysate temperature controller; the dialysate temperature controller calculates the dialysate target temperature based on the arterial side temperature and the venous side temperature according to the following continuous body temperature automatic adjustment method, and adjusts the dialysate temperature according to the dialysate target temperature; The continuous body temperature automatic regulation method is: During the dialysis phase, the arterial and venous temperatures of the extracorporeal blood circuit are collected in real time, and heat loss compensation is performed on the arterial and venous temperatures to obtain the arterial and venous blood temperatures at the fistula. An arteriovenous blood temperature curve is generated based on the arterial and venous blood temperatures at the fistula. The recirculation percentage of the vascular access is measured regularly, and the initial central body temperature is calculated based on the arterial blood temperature at the fistula, the venous blood temperature at the fistula, and the recirculation percentage: The initial central body temperature Among them, T art0 T is the initial arterial blood temperature at the fistula site; ven0 is the initial venous blood temperature at the fistula site, R0 is the recirculation percentage measured initially; Use the initial central body temperature as the target central body temperature and calculate the target venous blood temperature at the fistula: The target venous blood temperature at the fistula Among them, T art is the real-time arterial blood temperature at the fistula, R is the recirculation percentage, [t1, t2] refers to the pulse integration interval on the arteriovenous blood temperature curve when measuring the recirculation percentage, T art (t) refers to the arterial blood temperature at the fistula at time t on the arteriovenous blood temperature curve, T ven (t) refers to the venous blood temperature at the fistula at time t on the arteriovenous blood temperature curve; The target venous blood temperature at the fistula is compensated for the heat loss in the pipeline to obtain the target dialysate temperature; The dialysate temperature is controlled to stabilize it at the dialysate target temperature.

2. The continuous body temperature automatic regulation system according to claim 1, characterized in that: The measurement steps of the recycling percentage R are: Generate an arteriovenous blood temperature curve based on the arterial blood temperature and venous blood temperature at the fistula; A temperature change pulse is injected into the artery and vein through dialysate, and the recirculation percentage is calculated based on the stress pulse portion generated by the temperature change pulse according to the arteriovenous blood temperature curve.

3. The continuous body temperature automatic regulation system according to claim 1, characterized in that: Before or during dialysis, a target central body temperature change trend is set, and a target central body temperature change curve is generated based on the initial central body temperature and the target central body temperature change trend; During dialysis, the arterial and venous temperatures of the extracorporeal blood circuit are collected in real time; During dialysis, the target venous blood temperature at the fistula at time t was calculated based on the target central body temperature curve; The target venous blood temperature at the fistula at time t is compensated for the heat loss in the pipeline to obtain the target dialysate temperature at time t.

4. The continuous body temperature automatic regulation system according to claim 3, characterized in that: Target venous blood temperature at fistula at time t Among them, T bt is the target central body temperature at time t on the target central body temperature curve, T artt is the arterial blood temperature at the fistula at time t.

5. The continuous body temperature automatic regulation system according to any one of claims 1 to 4, characterized in that: Set the upper and lower limits of the dialysate temperature. When the dialysate target temperature is higher than the upper limit, the upper limit is used as the dialysate target temperature. When the dialysate target temperature is lower than the lower limit, the lower limit is used as the dialysate target temperature.

6. The continuous body temperature automatic regulation system according to claim 1, characterized in that: It also includes a heating module, which is connected to the dialysate temperature controller. The dialysate temperature controller controls the heating module to heat the dialysate so that the dialysate temperature is consistent with the dialysate target temperature.

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