Automatic spinal cord injury animal model preparation equipment

Abstract

The invention provides automatic spinal cord injury animal model preparation equipment which comprises a bottom table, a first adjusting table is arranged at the upper end of the bottom table, a connecting frame is arranged in the first adjusting table in a limiting sliding mode, a second adjusting table is arranged at the upper end of the bottom table, a moving table is arranged in the second adjusting table in a limiting sliding mode, and a controller is arranged on the surface of the bottom table. A placing table is arranged at the upper end of the moving table, and extension tables are arranged at the two ends of the placing table. According to the animal experiment table, through the arrangement of the placement table, the expansion table, the movable clamping jaw and the automatic expansion adaptation assembly, the space in the placement table can be adjusted, so that the animal experiment table can adapt to experiments of animals with large sizes, and the clamping mechanism can be automatically adjusted when the animals with the large sizes are placed; according to the invention, the device can automatically adapt according to the body type of an animal, is suitable for experiments of various animal types, is not limited to a specific body type or species any more, and improves the flexibility of the experiments.

Description

Technical Field

[0001] The invention relates to the technical field of spinal cord injury animal model preparation, in particular to automated spinal cord injury animal model preparation equipment. Background Art

[0002] Spinal cord injury usually leads to permanent functional defects below the injured segment, which seriously affects the patient's quality of life. How to repair spinal cord injury has long been a global problem. At present, the treatment of spinal cord injury mainly includes early surgical decompression, drug therapy and stem cell therapy, and there is no definite treatment method that can improve clinical symptoms. Therefore, studying spinal cord injury through an ideal animal model has great social significance.

[0003] By creating spinal cord injuries in animal models, researchers can better understand the physiological and biochemical changes after injury. A deeper understanding of these mechanisms helps find new therapeutic targets. By observing and measuring changes in the animals' motor abilities after injury, researchers can assess the severity of the injury and recovery. This provides data support for clinical applications.

[0004] However, when conducting experiments on animals of different sizes, due to their different sizes and types, manual adjustments are required, and it is not convenient to maintain the consistency of clamping force and position during each adjustment. In addition, repeated clamping and adjustment may cause injury to the animals, thus affecting the experiment. When conducting experiments on animals of different sizes, due to the different sizes of the animals, the length and density of their spines are also different. At this time, the original impact force is not convenient to damage the spine. In response to the above problems. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide an automated spinal cord injury animal model preparation device to solve the technical problem that it is inconvenient to maintain consistency in clamping force and position when conducting experiments on animals of different body sizes, and it is inconvenient to damage the spine, providing a solution that is significantly different from the prior art.

[0006] To solve the above problems, the present invention provides the following technical solutions:

[0007] An automated spinal cord injury animal model preparation device comprises a base, wherein a first adjustment platform is provided at the upper end of the base, a connecting frame is provided inside the first adjustment platform for limited sliding, a second adjustment platform is provided at the upper end of the base, a moving platform is provided inside the second adjustment platform for limited sliding, a controller is provided on the surface of the base, a placement platform is provided at the upper end of the moving platform, an extension platform is provided at both ends of the placement platform, a movable clamp is provided at the side end of the extension platform, an automatic expansion adapter component is provided at the bottom end and the side end of the placement platform, the automatic expansion adapter component can make the placement platform suitable for animals of different sizes, the connecting frame is provided with a movable plate for limited sliding, a movable plate is provided inside the movable plate for limited sliding, an impact head is provided at the bottom of the movable plate, and an electric push rod is provided on the surface of the movable plate;

[0008] A force adaptation and adjustment component is arranged on the surface and the back end of the movable plate, and is used to change the initial force of the impact according to the different body shapes of the animals.

[0009] Optionally, the automatic expansion adapter assembly includes a sliding rod and a bidirectional screw rod installed at the bottom of the placing table, the extension table slides in a limited position on the surface of the sliding rod, an auxiliary table is provided at the side end of the extension table, and the upper end of the auxiliary table is slidably connected to a rising table, a first oil tank is provided at the bottom of the placing table, a first piston rod is limitedly slidable inside the first oil tank, a second oil tank is provided inside the rising table, a second piston rod is limitedly slidable inside the second oil tank, a hose is connected between the first oil tank and the second oil tank, a pressure plate is provided at the end of the second piston rod, an extrusion block is provided inside the rising table, a slide is limitedly slid in the slide groove inside the rising table, the top of the slide is connected to the movable clamp, and a top plate is limitedly slid in the groove inside the slide.

[0010] Optionally, there are two groups of expansion platforms, and the two groups of expansion platforms are symmetrically distributed on the left and right sides of the placement platform, and the two groups of expansion platforms are threadedly connected to the bidirectional lead screw.

[0011] Optionally, a smooth inclined surface is provided at the bottom of the extrusion block, and a rounded corner is provided on the surface of the pressure plate.

[0012] Optionally, a bolt is rotatably connected to the back end of the top plate, and the bolt is threadedly connected to the inside of the slide.

[0013] Optionally, the force adaptation and adjustment component includes an oil chamber opened inside the auxiliary platform, a third piston rod is limitedly slidable inside the oil chamber, the top end of the third piston rod is connected to the bottom of the rising platform, an oil pipe is provided inside the connecting frame, a fourth piston rod and a fifth piston rod are limitedly slidable inside the oil pipe, the fourth piston rod and the fifth piston rod are both connected to the movable plate, a third oil tank is provided on the surface of the movable plate, a sixth piston rod is slidable inside the third oil tank, the sixth piston rod is connected to the electric push rod, a hose is connected between the third oil tank and the oil pipe, and a hose is connected between the oil pipe and the oil chamber.

[0014] Optionally, a tension spring is provided at the bottom of the movable plate, the other end of the tension spring is connected to the bottom of the movable plate, and the top of the movable plate is connected to the extended end of the electric push rod.

[0015] Optionally, the oil pipe is a bidirectional pipe, the fourth piston rod slides on the upper end of the oil pipe, and the fifth piston rod slides on the lower end of the oil pipe.

[0016] Optionally, the upper end of the fourth piston rod is connected to the top of the movable plate, and the lower end of the piston rod is connected to the bottom of the movable plate.

[0017] Optionally, the controller sends out a first control message, which drives the motor to drive the bidirectional screw to rotate, thereby driving the expansion table to slide on the surface of the sliding rod, so that the placement table can place animals of different sizes, and then fix the animals by movable clamps. At this time, the controller sends out a second control message, which drives the motor to control the connecting frame to move on the surface of the first adjustment table, and can adjust the impact height. The second control information drives the motor to control the placement table to move on the surface of the second adjustment table, thereby positioning the animal's spine, and then the controller sends out a third control message to drive the electric push rod to impact the spine.

[0018] Compared with the prior art, the technical solution provided by the present invention has at least the following beneficial effects:

[0019] In the above scheme, the space inside the placement table can be adjusted by setting up the placement table, expansion table, movable clamping claws and automatic expansion adaptation components, so as to adapt to experiments on some larger animals. When placing some larger animals, the clamping mechanism can be automatically adjusted so that it can be automatically adapted according to the body size of the animal, making it suitable for experiments on various animal species, no longer limited to a specific body size or species, increasing the flexibility of the experiment and avoiding the problem of inconsistent clamping force and position under manual adjustment.

[0020] By setting up the movable plate, moving plate, impact head, electric push rod and force adaptation adjustment components, when conducting experiments on animals of different sizes, the initial position of the movable plate can be adjusted according to the size of the experimental animals, and the impact force in the initial state can be changed. By adjusting the impact force, it can be ensured that the applied force is suitable for specific animals, avoiding excessive damage to the spine due to excessive force, or the problem of insufficient damage to the spine due to small impact force. Automatic adjustment of the impact force can ensure that the force and position applied in each experiment are consistent, reduce the impact caused by human factors, and improve the consistency and repeatability of experimental data. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The accompanying drawings, which are incorporated herein and constitute a part of the specification, illustrate embodiments of the invention and, together with the description, further serve to explain the principles of the invention and to enable those skilled in the relevant art to make and use the invention.

[0022] Figure 1 It is a schematic diagram of the workflow of the present invention;

[0023] Figure 2 It is a schematic diagram of the structure of the present invention;

[0024] Figure 3 It is a schematic diagram of the structure on the right side of the present invention;

[0025] Figure 4 It is a schematic diagram of the structure of the connecting frame and the mobile station;

[0026] Figure 5 This is a schematic diagram of the explosion structure of the placement platform;

[0027] Figure 6 for Figure 5 The enlarged structural diagram at A in the middle;

[0028] Figure 7 It is a schematic diagram of the explosion structure of the auxiliary platform and the rising platform;

[0029] Figure 8 for Figure 7 The enlarged structural diagram at B in the middle;

[0030] Fig. 9 It is a schematic diagram of the structure of the automatic expansion adapter component;

[0031] Fig.10 It is a schematic diagram of the cross-sectional structure of the oil pipe;

[0032] Fig.11 It is a schematic diagram of the structure of the movable plate and the activity plate;

[0033] Fig.12 for Figure 8 Enlarged structural diagram at B in the middle.

[0034] [Reference Signs]

[0035] 1. Base; 2. First adjustment platform; 3. Connecting frame; 4. Second adjustment platform; 5. Moving platform; 6. Controller; 7. Placement platform; 8. Extension platform; 9. Active gripper; 10. Automatic expansion adapter assembly; 101. Slide rod; 102. Bidirectional screw rod; 103. First oil tank; 104. First piston rod; 105. Rising platform; 106. Auxiliary platform; 107. Second oil tank; 108. Second piston rod; 109. Pressing plate; 1010. Extrusion block; 1011. Slide; 1012. Top plate; 11. Active plate; 12. Moving plate; 13. Impact head; 14. Electric push rod; 15. Force adaptation and adjustment assembly; 151. Oil chamber; 152. Third piston rod; 153. Oil pipe; 154. Fourth piston rod; 155. Fifth piston rod; 156. Third oil tank; 157. Sixth piston rod.

[0036] As shown in the figure, in order to clearly implement the structure of the embodiment of the present invention, specific structures and devices are marked in the figure, but this is only for illustrative purposes and is not intended to limit the present invention to the specific structure, device and environment. According to specific needs, ordinary technicians in this field can adjust or modify these devices and environments. DETAILED DESCRIPTION

[0037] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0038] like Figures 1 to 12 As shown, an embodiment of the present invention provides an automated spinal cord injury animal model preparation device, including a base 1, a first adjusting platform 2 is provided on the upper end of the base 1, a connecting frame 3 is provided inside the first adjusting platform 2 for limited sliding, a second adjusting platform 4 is provided on the upper end of the base 1, a moving platform 5 is provided inside the second adjusting platform 4 for limited sliding, a controller 6 is provided on the surface of the base 1, a placing platform 7 is provided on the upper end of the moving platform 5, extension platforms 8 are provided at both ends of the placing platform 7, movable clamps 9 are provided at the side ends of the extension platform 8, automatic expansion adapter components 10 are provided at the bottom end of the placing platform 7 and the side ends of the extension platform 8, the automatic expansion adapter components 10 can make the placing platform 7 suitable for use with animals of different sizes, a movable plate 11 is provided on the connecting frame 3 for limited sliding, a movable plate 12 is provided inside the movable plate 11 for limited sliding, an impact head 13 is provided at the bottom of the movable plate 12, and an electric push rod 14 is provided on the surface of the movable plate 11.

[0039] The force adaptation and adjustment component 15 is arranged on the surface and the back end of the movable plate 11, and the force adaptation and adjustment component 15 is used to change the initial force of the impact according to the different body shapes of the animals.

[0040] During use, when conducting experiments on animals of different sizes, due to their different sizes and types, manual adjustment is required when conducting experiments on animals of other types or sizes. However, it is inconvenient to keep the clamping force and position consistent every time the adjustment is made. This embodiment of the present invention can solve the above problems. The specific implementation method is as follows. When preparing the animal model, the animal is first placed on the surface of the placement table 7. At this time, according to the body size of the animal, the bidirectional lead screw 102 is driven by a motor to rotate, thereby driving the expansion table 8 to slide on the surface of the slide bar 101, and then the internal space of the placement table 7 can be expanded so that the internal space can adapt to the body size of the animal. When the expansion table 8 is adjusted on the surface of the slide bar 101, the first piston rod 104 The second piston rod 108 pushes the pressure plate 109 to contact the inclined surface of the extrusion block 1010, so that the lifting platform 105 slides upward on the upper end of the auxiliary platform 106. At this time, the movable jaw 9 extends upward, and the rotating bolt can slide the movable jaw 9 in the slide groove, so as to adjust the clamping range of the jaw. The adjustment of the movable jaw 9 can fix large animals on the surface of the placement platform 7. The movable platform 5 is driven by the controller 6 to move in the second adjustment platform 4, so as to locate the animal's spine. Then, the connecting frame 3 is moved in the first adjustment platform 2 to adjust the impact height.

[0041] like Figures 5 to 8 As shown, the automatic expansion adapter assembly 10 includes a slide bar 101 and a bidirectional screw rod 102 installed at the bottom of the placement table 7, the expansion table 8 is limitedly slid on the surface of the slide bar 101, the side end of the expansion table 8 is provided with an auxiliary table 106, and the upper end of the auxiliary table 106 is slidably connected to a rising table 105, a first oil tank 103 is provided at the bottom of the placement table 7, a first piston rod 104 is limitedly slid inside the first oil tank 103, a second oil tank 107 is provided inside the rising table 105, and a second piston rod 104 is limitedly slid inside the second oil tank 107 Rod 108, a hose is connected between the first oil tank 103 and the second oil tank 107, a pressure plate 109 is provided at the end of the second piston rod 108, an extrusion block 1010 is provided inside the rising platform 105, a slide 1011 is provided in the internal slide groove of the rising platform 105 for limiting sliding, the top of the slide 1011 is connected to the movable clamp 9, and a top plate 1012 is provided in the internal groove of the slide 1011 for limiting sliding. The opening of the automatic expansion component can adjust the space inside the placement table 7, so that it can be used for animals of different sizes.

[0042] like Figure 7As shown, there are two groups of expansion platforms 8, which are symmetrically distributed on the left and right sides of the placement platform 7. The two groups of expansion platforms 8 are threadedly connected to the bidirectional screw rod 102. When the bidirectional screw rod 102 rotates, it will drive the expansion platform 8 to expand to both sides, thereby automatically adjusting the internal space.

[0043] like Figure 6 As shown, the bottom of the extrusion block 1010 is provided with a smooth inclined surface, and the surface of the pressure plate 109 is provided with a rounded corner. The rounded corner of the surface of the pressure plate 109 facilitates the extrusion of the extrusion block 1010, and the inclined surface at the lower end of the extrusion block 1010 can drive the movable clamp 9 to rise synchronously when the expansion platform 8 is extended.

[0044] like Figure 8 As shown, the back end of the top plate 1012 is rotatably connected with a bolt, and the bolt is threadedly connected to the inner part of the slide 1011. Rotating the bolt can drive the top plate 1012 to move in the inner groove of the slide 1011, thereby fixing the clamping table.

[0045] like Figures 8 to 12 As shown, the force adaptation and adjustment component 15 includes an oil chamber 151 opened inside the auxiliary platform 106, a third piston rod 152 is limited and slidable inside the oil chamber 151, the top of the third piston rod 152 is connected to the bottom of the rising platform 105, an oil pipe 153 is provided inside the connecting frame 3, a fourth piston rod 154 and a fifth piston rod 155 are limited and slidable inside the oil pipe 153, the fourth piston rod 154 and the fifth piston rod 155 are both connected to the movable plate 11, a third oil tank 156 is provided on the surface of the movable plate 11, a sixth piston rod 157 is slidable inside the third oil tank 156, the sixth piston rod 157 is connected to the electric push rod 14, a hose is connected between the third oil tank 156 and the oil pipe 153, and the oil pipe 153 is connected to the electric push rod 14. A hose is connected to the oil chamber 151. The force adaptation adjustment component 15 can adjust the initial position of the movable plate 12 according to the size of the experimental animals when conducting experiments on animals of different sizes, and can change the impact force in the initial state. By adjusting the impact force, it can be ensured that the applied force is suitable for specific animals.

[0046] like Fig.11 As shown, a tension spring is provided at the bottom of the movable plate 12, and the other end of the tension spring is connected to the bottom of the movable plate 11. The top of the movable plate 12 is connected to the extended end of the electric push rod 14. The establishment of the distance between the movable plate 12 and the movable plate 11 can adjust the initial impact force of the impact head 13.

[0047] like Fig.10As shown, the oil pipe 153 is a two-way pipe, the fourth piston rod 154 slides on the upper end of the oil pipe 153, the fifth piston rod 155 slides on the lower end of the oil pipe 153, and is connected to the bottom of the movable plate 11. The opening of the two-way pipe can drive the fourth piston rod 154 to move inside the oil pipe 153 when the fifth piston rod 155 is squeezed by oil.

[0048] The upper end of the fourth piston rod 154 is connected to the top of the movable plate 11, and the lower end of the fifth piston rod 155 is connected to the bottom of the movable plate 11. When the movable plate 11 rises, it can drive the moving plate 12 to rise on the surface of the movable plate 11, thereby adjusting the distance between the movable plates 11 and 12.

[0049] The controller 6 sends out a first control message, and the first control message drives the motor to drive the bidirectional screw 102 to rotate, thereby driving the extension table 8 to slide on the surface of the slide bar 101, so that the placement table 7 can place animals of different sizes, and then fix the animals through the movable clamp 9. At this time, the controller 6 sends out a second control message, and the second control message drives the motor to control the connecting frame 3 to move on the surface of the first adjustment table 2, so as to adjust the impact height. The second control message drives the motor to control the placement table 7 to move on the surface of the second adjustment table 4, so as to position the animal's spine, and then the controller 6 sends out a third control message to drive the electric push rod 14 to impact the spine.

[0050] The working process of the technical solution provided by the present invention is as follows:

[0051] When preparing an animal model, the animal is first placed on the surface of the placement table 7. At this time, according to the body shape of the animal, the bidirectional screw rod 102 is driven by the motor to rotate, thereby driving the expansion table 8 to slide on the surface of the slide bar 101, and then the internal space of the placement table 7 can be expanded to make the internal space adapt to the body shape of the animal. When the expansion table 8 is adjusted on the surface of the slide bar 101, the first piston rod 104 is squeezed, so that the oil in the first oil tank 103 is injected into the second oil tank 107. At this time, the second piston rod 108 pushes the pressure plate 109 and the extrusion plate 109. The inclined surfaces of the blocks 1010 are in contact with each other, so that the lifting platform 105 slides upward on the upper end of the auxiliary platform 106. At this time, the movable jaw 9 will extend upward. The rotating bolt can slide the movable jaw 9 inside the slide groove, so as to adjust the clamping range of the jaw. The adjustment of the movable jaw 9 can fix large animals on the surface of the placement platform 7. The movable platform 5 is driven by the controller 6 to move in the second adjustment platform 4, so as to locate the animal's spine position, and then the connecting frame 3 is moved inside the first adjustment platform 2 to adjust the impact height.

[0052] When the rising platform 105 extends upward on the upper end of the auxiliary platform 106, the oil in the oil chamber 151 will be injected into the oil tube 153 to enable the movable plate 11 to move on the surface of the connecting frame 3. When the movable plate 11 moves on the surface of the connecting frame 3, the oil in the oil tube 153 will be injected into the third oil tank 156, thereby driving the sixth piston rod 157 to drive the electric push rod 14 to move upward, thereby increasing the distance between the movable plate 12 and the movable plate 11. At this time, the extension of the electric push rod 14 pushes the impact head 13 to damage the spine. At this time, the increased distance between the movable plate 12 and the movable plate 11 will increase the impact force of the impact head 13.

[0053] The present invention covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present invention. In order to make the public have a thorough understanding of the present invention, specific details are described in detail in the following preferred embodiments of the present invention, but those skilled in the art can fully understand the present invention without the description of these details. In addition, in order to avoid unnecessary confusion about the essence of the present invention, well-known methods, processes, procedures, components and circuits are not described in detail.

[0054] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An automated spinal cord injury animal model preparation device, comprising a base, characterized in that: The upper end of the base platform is provided with a first adjustment platform, the first adjustment platform has a connecting frame for limited sliding inside, the upper end of the base platform is provided with a second adjustment platform, the second adjustment platform has a moving platform for limited sliding inside, the surface of the base platform is provided with a controller, the upper end of the moving platform is provided with a placement platform, the two ends of the placement platform are provided with expansion platforms, the side ends of the expansion platform are provided with movable clamps, the bottom end of the placement platform and the side ends of the expansion platform are provided with automatic expansion adapter components, the automatic expansion adapter components can make the placement platform suitable for animals of different sizes, the connecting frame has a movable plate for limited sliding, the movable plate has a movable plate for limited sliding inside, the bottom of the movable plate is provided with an impact head, and the surface of the movable plate is provided with an electric push rod; It also includes a force adaptation and adjustment component, which is arranged on the surface and the back end of the movable plate, and is used to change the initial force of the impact according to the different body shapes of the animals.

2. The automated spinal cord injury animal model preparation device according to claim 1, characterized in that: The automatic expansion adapter assembly includes a sliding rod and a bidirectional screw rod installed at the bottom of the placement table, the expansion table slides in a limited position on the surface of the sliding rod, an auxiliary table is provided at the side end of the expansion table, and a rising table is slidably connected to the upper end of the auxiliary table, a first oil tank is provided at the bottom of the placement table, a first piston rod is limitedly slidable inside the first oil tank, a second oil tank is provided inside the rising table, a second piston rod is limitedly slidable inside the second oil tank, a hose is connected between the first oil tank and the second oil tank, a pressure plate is provided at the end of the second piston rod, and an extrusion block is provided inside the rising table.

3. The automated spinal cord injury animal model preparation device according to claim 2, characterized in that: A slide is provided in the sliding groove inside the rising platform for limited sliding, the top of the slide is connected with the movable clamping claw, and a top plate is provided in the groove inside the slide for limited sliding.

4. The automated spinal cord injury animal model preparation device according to claim 2, characterized in that: The number of the expansion platforms is two groups, and the two groups of expansion platforms are symmetrically distributed on the left and right sides of the placement platform. The two groups of expansion platforms are threadedly connected with the bidirectional lead screw.

5. The automated spinal cord injury animal model preparation device according to claim 2, characterized in that: The bottom of the extrusion block is provided with a smooth inclined surface, and the surface of the pressing plate is provided with a rounded corner.

6. The automated spinal cord injury animal model preparation device according to claim 3, characterized in that: The back end of the top plate is rotatably connected with a bolt, and the bolt is threadedly connected to the inner part of the slide.

7. The automated spinal cord injury animal model preparation device according to claim 2, characterized in that: The force adaptation and adjustment component includes an oil cavity opened inside the auxiliary platform, a third piston rod is limitedly slidable inside the oil cavity, the top end of the third piston rod is connected to the bottom of the rising platform, an oil pipe is provided inside the connecting frame, a fourth piston rod and a fifth piston rod are limitedly slidable inside the oil pipe, the fourth piston rod and the fifth piston rod are both connected to a movable plate, a third oil tank is provided on the surface of the movable plate, a sixth piston rod is slidable inside the third oil tank, the sixth piston rod is connected to an electric push rod, a hose is connected between the third oil tank and the oil pipe, and a hose is connected between the oil pipe and the oil cavity.

8. The automated spinal cord injury animal model preparation device according to claim 1, characterized in that: A tension spring is arranged at the bottom of the movable plate, the other end of the tension spring is connected to the bottom of the movable plate, and the top of the movable plate is connected to the extended end of the electric push rod.

9. The automated spinal cord injury animal model preparation device according to claim 7, characterized in that: The oil pipe is a bidirectional pipe, the fourth piston rod slides on the upper end of the oil pipe, and the fifth piston rod slides on the lower end of the oil pipe.

10. The automated spinal cord injury animal model preparation device according to claim 7, characterized in that: The upper end of the fourth piston rod is connected to the top of the movable plate, and the lower end of the piston rod is connected to the bottom of the movable plate.

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