Preparation method and device of pharmaceutical composition for respiratory system diseases

Abstract

The pharmaceutical composition for respiratory system diseases is prepared from the following components in parts by weight: 1 to 1.5 parts of camphor, 0.6 to 1.2 parts of menthol, 1 to 2 parts of radix astragali seu hedysari powder, 0.5 to 1.0 part of radix scutellariae, 0.3 to 0.6 part of fructus arctii, 0.3 to 0.6 part of flos chrysanthemi, 0.5 to 1.0 part of liquorice root, 0.5 to 1.0 part of herba pogostemonis, 0.3 to 0.6 part of vanilla and 0.3 to 0.6 part of flos caryophylli. According to the preparation method, coarse and fine particles are mixed and extracted more thoroughly, the extraction efficiency is high, pressurized distillation is matched, the extraction efficiency is further improved, and matched devices are matched, Chinese herbal medicine particles and powder are placed in different net cylinders and distilled from inside to outside, so that the Chinese herbal medicine particles and the powder are separated from the net cylinders, and the Chinese herbal medicine particles and the powder are separated from the net cylinders. The rotary distillation net cylinder can open and close air holes in the distillation net cylinder, the requirements of soaking, distillation, filtration and the like are met, the extraction efficiency is further improved, the distillation net cylinder is detachably connected, internal cleaning is convenient, and operation is easy and convenient.

Description

Technical Field

[0001] The present invention belongs to the technical field of drug preparation and device thereof, and specifically relates to a method and device for preparing a drug composition for respiratory diseases. Background Art

[0002] Respiratory diseases are common and frequently occurring diseases. They mainly affect the trachea, bronchi, lungs and chest cavity. Mild cases often cause coughing, chest pain and respiratory problems. Severe cases may cause breathing difficulties, hypoxia and even respiratory failure leading to death. In cities, respiratory diseases rank third in mortality, while in rural areas they rank first.

[0003] More importantly, due to factors such as air pollution, smoking, and an aging population, the incidence and mortality of chronic obstructive pulmonary disease (including chronic bronchitis, emphysema, cor pulmonale), bronchial asthma, lung cancer, diffuse interstitial fibrosis of the lungs, and lung infections are increasing. Prevention or treatment of upper respiratory tract infections in adults or children is usually achieved by injection or oral administration, but these methods are not effective in prevention and treatment. The treatment process will cause pain and discomfort to the patient, especially to children who are afraid of pain and hate the taste of medicine. The compliance rate of injection and oral administration is very low, which affects the treatment effect.

[0004] And the treatment drugs are mainly western medicine, which will produce certain side effects to a greater or lesser extent. In recent years, the number of Chinese medicines used to prevent and treat respiratory diseases has increased. The present invention aims to provide a machine preparation method for a pharmaceutical composition for respiratory diseases. In the preparation process, the device for extracting Chinese medicine is particularly important. The existing device has low extraction efficiency, unchanged operation, and difficult cleaning. The present invention also provides an efficient and easy-to-clean preparation device for a pharmaceutical composition for respiratory diseases. Summary of the invention

[0005] To solve the above problems, the present invention discloses a pharmaceutical composition for respiratory diseases, which can enhance the body's disease resistance and treat both the symptoms and the root cause. The preparation method has high extraction efficiency and is matched with a matching device to improve the extraction efficiency, facilitate internal cleaning, and is easy to operate.

[0006] To achieve the above object, the technical solution of the present invention is as follows: The invention provides a pharmaceutical composition for respiratory diseases. The pharmaceutical composition comprises, by weight, 1-1.5 parts of camphor, 0.6-1.2 parts of menthol, 1-2 parts of astragalus powder, 0.5-1.0 parts of scutellaria, 0.3-0.6 parts of burdock fruit, 0.3-0.6 parts of chrysanthemum, 0.5-1.0 parts of liquorice, 0.5-1.0 parts of patchouli, 0.3-0.6 parts of vanilla and 0.3-0.6 parts of cloves; and also comprises a pH regulator, which is citric acid or sodium citrate.

[0007] The present invention also provides a method for preparing a pharmaceutical composition for respiratory diseases, comprising the following steps: S1. Wash and dry the astragalus root, crush it into fine particles of 100-500 mesh and coarse particles of 10-50 mesh, mix the coarse particles with the fine particles, steam distill with distilled water for 2-6 hours, filter to obtain a filtrate and a filter residue, and concentrate the filtrate to obtain solution A; S2, reflux extraction of the filter residue with ethanol for 3 times, each time for 2-3 hours, and combining to obtain solution B; S3, combining solution A and solution B, stirring thoroughly, collecting supernatant A, and concentrating to a relative density of 1.1-1.2 to obtain extract A; S4. 1-1.5 parts of camphor, 0.6-1.2 parts of menthol, 0.5-1.0 parts of scutellaria, 0.3-0.6 parts of burdock, 0.3-0.6 parts of chrysanthemum, 0.5-1.0 parts of liquorice, 0.5-1.0 parts of patchouli, 0.3-0.6 parts of vanilla and 0.3-0.6 parts of cloves were ground into a mixture of 60-100 mesh, 0.5-1.5 times the volume of distilled water was added to the mixture without running water, and the mixture was placed in a sealed container and passed through N 2 After soaking for 12-24 hours, use steam distillation for 3-24 hours, collect the distillate, add 1-2 times the volume of distilled water to the mixture after distillation, soak for 2-5 days, and collect the soaking liquid; S5, after mixing the distillate and the soaking liquid, add ethanol and let the mixture stand, collect the supernatant B, concentrate it to a relative density of 1.1-1.2 to obtain extract B, and adjust the pH to 7.0-7.5 using a pH adjuster; S6. Drying extract A into powder to obtain active ingredient A, drying extract B into powder to obtain active ingredient B, and mixing 1-2 parts of active ingredient A with all of active ingredient B by weight to obtain a pharmaceutical composition for respiratory diseases.

[0008] Furthermore, in step S1, the mass ratio of coarse particles to fine particles is 1:1-2, and the pressure of steam distillation is 0.2-1.0 MPa.

[0009] Furthermore, in step S4, the pressure of the steam distillation is 0.5-1.5 MPa.

[0010] The present invention also provides a device for preparing a pharmaceutical composition for respiratory diseases, which is a sealed container as described in claim 2, comprising a tank body and a tank cover, a constant temperature control shell is arranged on the side outside the tank body, a heating mechanism is arranged on the bottom outside the tank body, a water inlet and outlet are arranged at the bottom of the tank body, a gas control port is arranged at the upper part of the tank body, an air distribution mechanism is arranged in the tank body, a distillation mesh cylinder is sleeved on the air distribution mechanism, the bottom of the tank body is a hemispherical steam chamber, an electric motor is arranged at the center of the tank cover, the electric motor is connected to a stirring shaft, the stirring shaft passes through the air distribution mechanism and the distillation mesh cylinder and is placed in the steam chamber, and a stirring paddle is arranged at the bottom of the stirring shaft.

[0011] Furthermore, the gas distribution mechanism includes a first positioning plate, which is fixedly arranged on the inner wall of the tank body above the steam chamber, and a first supporting mesh cylinder, a second supporting mesh cylinder, and a third supporting mesh cylinder are coaxially arranged on the first positioning plate from outside to inside; the second supporting mesh cylinder and the third supporting mesh cylinder are hollow structures, and a second positioning plate is arranged on the edge of the open end of the distillation mesh cylinder, and the second positioning plate is placed between the tank body and the tank cover. The distillation mesh cylinder is coaxially arranged with the first mesh cylinder, the second mesh cylinder, and the third mesh cylinder from outside to inside with the second positioning plate, the second mesh cylinder and the third mesh cylinder are hollow structures, and the vertical cross-section of the gas distribution mechanism and the distillation mesh cylinder is a bow-shaped structure.

[0012] Furthermore, the first positioning plate is provided with an annular vent hole and second through holes evenly distributed in an annular shape, and the annular vent holes are respectively arranged outside the first supporting mesh tube, at the bottom of the second supporting mesh tube, and at the bottom of the third supporting mesh tube.

[0013] The beneficial effects of the present invention are: The present invention discloses a pharmaceutical composition for respiratory diseases, which can enhance the body's disease resistance and treat both the symptoms and the root causes. In its preparation method, coarse and fine particles are mixed, extraction is more thorough, and extraction efficiency is high. Pressure distillation is combined to further improve extraction efficiency. In combination with a matching device, Chinese herbal medicine particles and powder are placed in different mesh cylinders, and distillation is performed from the inside to the outside. The rotating distillation mesh cylinder can open and close the air holes on the distillation mesh cylinder to meet the needs of immersion distillation and filtration, further improving extraction efficiency. The distillation mesh cylinder can be detachably connected, the interior is easy to clean, and the operation is simple. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 A schematic diagram of the three-dimensional structure of a device for preparing a pharmaceutical composition for respiratory diseases according to the present invention; Figure 2 This is a schematic diagram of the internal structure of the device for preparing a pharmaceutical composition for respiratory diseases according to the present invention.

[0015] List of Figure Symbols: 1. Tank body; 2. distillation mesh cylinder; 3. tank cover; 4. constant temperature control shell; 5. motor; 6. second positioning plate; 7. first mesh cylinder; 8. second mesh cylinder; 9. water inlet and outlet; 10. third mesh cylinder; 11. first supporting mesh cylinder; 12. second supporting mesh cylinder; 13. third supporting mesh cylinder; 14. annular vent hole; 15. gas control port (17); 16. second through hole; 18. stirring shaft; 19. stirring paddle. DETAILED DESCRIPTION

[0016] The present invention will be further explained below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the following specific embodiments are only used to illustrate the present invention and are not used to limit the scope of the present invention.

[0017] Example 1 A pharmaceutical composition for respiratory diseases, comprising, by weight, 1 part of camphor, 1 part of menthol, 2 parts of astragalus powder (active ingredient A), 1.0 part of scutellaria, 0.6 part of burdock fruit, 0.6 part of chrysanthemum, 0.5 part of licorice, 0.8 part of patchouli, 0.5 part of vanilla, and 0.5 part of clove; pH adjusters are citric acid and sodium citrate.

[0018] The preparation method comprises the following steps: S1. Wash and dry the astragalus root, crush it into fine particles of 200-300 mesh and coarse particles of 20-30 mesh, mix the coarse particles with the fine particles, and the mass ratio of the coarse particles to the fine particles is 1:1.5. After steam distillation with distilled water for 4 hours, the pressure of the steam distillation is 0.5-0.7Mpa, filter to obtain a filtrate and a filter residue, and concentrate the filtrate to obtain solution A; S2, reflux extraction of the filter residue with ethanol for 3 times, each time for 2-3 hours, and combining to obtain solution B; S3, combining solution A and solution B, stirring thoroughly, collecting supernatant A, and concentrating to a relative density of 1.1-1.2 to obtain extract A; S4. Crush camphor, menthol, scutellaria, burdock, chrysanthemum, liquorice, patchouli, vanilla and clove by weight to obtain a mixture of 60-80 mesh. Add 1 volume of distilled water to the mixture without running water, place it in a sealed container, and pass N 2 After soaking for 24 hours, steam distillation was performed for 12 hours, and the distillate was collected. The pressure of the steam distillation was 1.0-1.2Mpa. Two times the volume of distilled water was added to the mixture after distillation and soaked for 3 days, and then the soaking liquid was collected; S5, after mixing the distillate and the soaking liquid, add ethanol and let the mixture stand, collect the supernatant B, concentrate it to a relative density of 1.1-1.2 to obtain extract B, and adjust the pH to 7.0-7.5 using a pH adjuster; S6. Drying extract A into powder to obtain active ingredient A, drying extract B into powder to obtain active ingredient B, and mixing 2 parts of active ingredient A with all of active ingredient B by weight to obtain a pharmaceutical composition for respiratory diseases.

[0019] Example 2 A pharmaceutical composition for respiratory diseases, comprising, by weight, 1.5 parts of camphor, 1.2 parts of menthol, 2 parts of astragalus powder, 1.0 part of scutellaria, 0.6 part of burdock fruit, 0.6 part of chrysanthemum, 1.0 part of liquorice, 1.0 part of patchouli, 0.6 part of vanilla, and 0.6 part of clove; pH regulators are citric acid and sodium citrate.

[0020] The preparation method comprises the following steps: S1. Wash and dry the astragalus root, crush it into fine particles of 100-200 mesh and coarse particles of 10-20 mesh, mix the coarse particles with the fine particles, steam distill them with distilled water for 6 hours, filter to obtain a filtrate and a filter residue, and concentrate the filtrate to obtain solution A; the mass ratio of the coarse particles to the fine particles is 1:1-2, and the pressure of the steam distillation is 0.5-1.0Mpa; S2, reflux extraction of the filter residue with ethanol for 3 times, each time for 2-3 hours, and combining to obtain solution B; S3, combining solution A and solution B, stirring thoroughly, collecting supernatant A, and concentrating to a relative density of 1.1-1.2 to obtain extract A; S4. Crush camphor, menthol, scutellaria, burdock, chrysanthemum, liquorice, patchouli, vanilla and clove by weight to obtain a mixture of 80-100 mesh. Add 1.2 times the volume of distilled water to the mixture without running water, place it in a sealed container, and pass N 2 After soaking for 24 hours, steam distillation was performed for 10 hours, and the distillate was collected. The pressure of the steam distillation was 0.8-1.0Mpa. Two times the volume of distilled water was added to the mixture after distillation and soaked for 5 days, and then the soaking liquid was collected; S5, after mixing the distillate and the soaking liquid, add ethanol and let the mixture stand, collect the supernatant B, concentrate it to a relative density of 1.1-1.2 to obtain extract B, and adjust the pH to 7.0-7.5 using a pH adjuster; S6. Drying extract A into powder to obtain active ingredient A, drying extract B into powder to obtain active ingredient B, and mixing 1-2 parts of active ingredient A with all of active ingredient B by weight to obtain a pharmaceutical composition for respiratory diseases. Example 3

[0021] A device for preparing a pharmaceutical composition for respiratory diseases, the device is the sealed container described in the above embodiment, including a tank body and a tank cover, a constant temperature control shell is arranged on the side outside the tank body, a heating mechanism is arranged on the bottom outside the tank body, a water inlet and outlet are arranged at the bottom of the tank body, a gas control port is arranged on the upper part of the tank body, an air distribution mechanism is arranged in the tank body, a distillation mesh cylinder is sleeved on the air distribution mechanism, the bottom of the tank body is a hemispherical steam chamber, an electric motor is arranged at the center of the tank cover, the electric motor is connected to a stirring shaft, the stirring shaft passes through the air distribution mechanism and the distillation mesh cylinder and is placed in the steam chamber, and a stirring paddle is arranged at the bottom of the stirring shaft.

[0022] The gas distribution mechanism includes a first positioning plate, which is fixedly arranged on the inner wall of the tank body above the steam chamber, and the first supporting mesh cylinder, the second supporting mesh cylinder, and the third supporting mesh cylinder are coaxially arranged on the first positioning plate from the outside to the inside; the second supporting mesh cylinder and the third supporting mesh cylinder are hollow structures, and a second positioning plate is arranged on the edge of the opening end of the distillation mesh cylinder, and the second positioning plate is placed between the tank body and the tank cover. The distillation mesh cylinder is coaxially arranged with the first mesh cylinder, the second mesh cylinder, and the third mesh cylinder from the outside to the inside with the second positioning plate, the second mesh cylinder and the third mesh cylinder are hollow structures, and the vertical cross-section of the gas distribution mechanism and the distillation mesh cylinder is a bow-shaped structure.

[0023] The first positioning plate is provided with an annular vent hole and second through holes evenly distributed in an annular shape. The annular vent holes are respectively arranged outside the first supporting mesh tube, at the bottom of the second supporting mesh tube, and at the bottom of the third supporting mesh tube.

[0024] Working principle: The distillation mesh cylinder is inserted into the gas distribution mechanism, the crushed target Chinese medicine or Chinese medicine mixture is added into the distillation mesh cylinder, the tank lid is closed, distilled water or other extraction solvents are added to the bottom, the gas control port is opened to control the volume of gas and pressure in the tube, the constant temperature control shell and the heating mechanism are opened for insulation and heating, and the steam is evenly dispersed from the annular vents, from the outside of the first supporting mesh cylinder, the bottom of the second supporting mesh cylinder, and the third supporting mesh cylinder through the first mesh cylinder, the second mesh cylinder, and the third mesh cylinder into the Chinese herbal mixture, and then comes out from the second through hole for cyclic distillation.

[0025] It should be noted that the above content merely illustrates the technical idea of ​​the present invention and cannot be used to limit the protection scope of the present invention. For ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications all fall within the protection scope of the claims of the present invention.

Claims

1. A pharmaceutical composition for respiratory diseases, characterized in that: The invention comprises, by weight, 1-1.5 parts of camphor, 0.6-1.2 parts of menthol, 1-2 parts of astragalus powder, 0.5-1.0 parts of scutellaria, 0.3-0.6 parts of burdock fruit, 0.3-0.6 parts of chrysanthemum, 0.5-1.0 parts of licorice, 0.5-1.0 parts of patchouli, 0.3-0.6 parts of vanilla and 0.3-0.6 parts of cloves; and also comprises a pH regulator, which is citric acid or sodium citrate.

2. A method for preparing a pharmaceutical composition for respiratory diseases, characterized in that: The following steps are involved: S1. Wash and dry the astragalus root, crush it into fine particles of 100-500 mesh and coarse particles of 10-50 mesh, mix the coarse particles with the fine particles, steam distill with distilled water for 2-6 hours, filter to obtain a filtrate and a filter residue, and concentrate the filtrate to obtain solution A; S2, reflux extraction of the filter residue with ethanol for 3 times, each time for 2-3 hours, and combining to obtain solution B; S3, combining solution A and solution B, stirring thoroughly, collecting supernatant A, and concentrating to a relative density of 1.1-1.2 to obtain extract A; S4, by weight, 1-1.5 parts of camphor, 0.6-1.2 parts of menthol, 0.5-1.0 parts of scutellaria, 0.3-0.6 parts of burdock, 0.3-0.6 parts of chrysanthemum, 0.5-1.0 parts of liquorice, 0.5-1.0 parts of patchouli, 0.3-0.6 parts of vanilla, and 0.3-0.6 parts of cloves are crushed to obtain a mixture of 60-100 mesh, 0.5-1.5 times the volume of distilled water is added to the mixture, no running water is placed in a sealed container, and N2 is passed through, soaked for 12-24 hours, steam distilled for 3-24 hours, the distillate is collected, and 1-2 times the volume of distilled water is added to the distilled mixture and soaked for 2-5 days, and the soaking liquid is collected; S5, after mixing the distillate and the soaking liquid, add ethanol and let the mixture stand, collect the supernatant B, concentrate it to a relative density of 1.1-1.2 to obtain extract B, and adjust the pH to 7.0-7.5 using a pH adjuster; S6. Drying extract A into powder to obtain active ingredient A, drying extract B into powder to obtain active ingredient B, and mixing 1-2 parts of active ingredient A with all of active ingredient B by weight to obtain a pharmaceutical composition for respiratory diseases.

3. The method for preparing a pharmaceutical composition for respiratory diseases according to claim 2, characterized in that: In step S1, the mass ratio of coarse particles to fine particles is 1:1-2, and the pressure of steam distillation is 0.2-1.0 MPa.

4. The method for preparing a pharmaceutical composition for respiratory diseases according to claim 2, characterized in that: In step S4, the pressure of steam distillation is 0.5-1.5 MPa.

5. A device for preparing a pharmaceutical composition for respiratory diseases, characterized in that: The device is a sealed container as described in claim 2, comprising a tank body and a tank cover, a constant temperature control shell is arranged on the side outside the tank body, a heating mechanism is arranged on the bottom outside the tank body, a water inlet and outlet are arranged at the bottom of the tank body, a gas control port is arranged on the upper part of the tank body, an air distribution mechanism is arranged in the tank body, a distillation mesh cylinder is arranged on the air distribution mechanism, the bottom of the tank body is a hemispherical steam chamber, an electric motor is arranged at the center of the tank cover, the electric motor is connected to a stirring shaft, the stirring shaft passes through the air distribution mechanism and the distillation mesh cylinder and is placed in the steam chamber, and a stirring paddle is arranged at the bottom of the stirring shaft.

6. The device for preparing a pharmaceutical composition for respiratory diseases according to claim 5, characterized in that: The gas distribution mechanism includes a first positioning plate, which is fixedly arranged on the inner wall of the tank body above the steam chamber, and the first supporting mesh cylinder, the second supporting mesh cylinder, and the third supporting mesh cylinder are coaxially arranged on the first positioning plate from the outside to the inside; the second supporting mesh cylinder and the third supporting mesh cylinder are hollow structures, and a second positioning plate is arranged on the edge of the opening end of the distillation mesh cylinder, and the second positioning plate is placed between the tank body and the tank cover. The distillation mesh cylinder is coaxially arranged with the first mesh cylinder, the second mesh cylinder, and the third mesh cylinder from the outside to the inside with the second positioning plate, the second mesh cylinder and the third mesh cylinder are hollow structures, and the vertical cross-section of the gas distribution mechanism and the distillation mesh cylinder is a bow-shaped structure.

7. The device for preparing a pharmaceutical composition for respiratory diseases according to claim 6, characterized in that: The first positioning plate is provided with an annular vent hole and second through holes evenly distributed in an annular shape. The annular vent holes are respectively arranged outside the first supporting mesh tube, at the bottom of the second supporting mesh tube, and at the bottom of the third supporting mesh tube.

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