Novel traditional Chinese medicine formula for treating allergic asthma

Abstract

The invention discloses a novel traditional Chinese medicine formula for treating allergic asthma, and belongs to the technical field of traditional Chinese medicines. The novel traditional Chinese medicine formula comprises the following components in parts by weight: 20-40 parts of lucid ganoderma, 4-8 parts of radix sophorae flavescentis, 3-9 parts of honey-fried licorice root and 30-60 parts of radix rubiae. Lucid ganoderma, radix sophorae flavescentis, honey-fried licorice root and radix rubiae are used as main components, the symptoms, such as wheeze, cough and chest distress, of allergic asthma patients can be effectively relieved, and the living quality of the patients is improved; natural traditional Chinese medicinal materials are adopted, side effects on the human body are small, and safety is high; the traditional Chinese medicine can quickly relieve symptoms of patients and shorten the treatment cycle.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically refers to a new traditional Chinese medicine formula for treating allergic asthma. Background Art

[0002] Bronchial asthma (abbreviated as asthma) is a chronic airway inflammatory disease involving multiple cells and components. Eosinophils are the main inflammatory effector cells of asthma, and eosinophilic airway inflammation easily leads to poor asthma control. In recent years, some new biological treatments such as anti-IL-5 antibodies, anti-IL-5 receptor antibodies and anti-IL-13 receptor antibodies have been used in clinical practice, but due to the high price of such drugs and the high risk of recurrence after discontinuation of the drugs, some asthma patients cannot obtain effective control.

[0003] The pathogenesis of allergic asthma is complex and is closely related to genetic, environmental, and immune factors. At present, Western medicine mainly uses glucocorticoids, bronchodilators, antiallergic drugs, etc. to treat allergic asthma. Although these drugs have certain effects in relieving symptoms, long-term use may cause many side effects, such as osteoporosis, immunosuppression, gastrointestinal reactions, etc. Traditional Chinese medicine has a long history and rich experience in treating allergic asthma. Chinese medicine believes that allergic asthma is mostly caused by dysfunction of the lungs, spleen, and kidneys, invasion of exogenous evil, induced phlegm, and lung qi rising. Through syndrome differentiation and treatment, the use of Chinese medicine to regulate the overall function of the human body can achieve the purpose of treating both the symptoms and the root causes. However, the existing Chinese medicine formula still has certain limitations in the treatment of allergic asthma, such as unstable efficacy and long treatment cycle.

[0004] Previous studies have confirmed that the Chinese medicine formula Ai Ximei (English abbreviation ASHMI) has obvious advantages in improving asthma symptoms, total blood IgE, eosinophils, etc., and plays an anti-inflammatory, immunomodulatory, and anti-allergic effect. In recent years, the anti-allergic effect of madder has been reported. The present invention aims to combine the use of the new formula of Ai Ximei + madder on the basis of conventional asthma standardized drug treatment in adult asthma patients with high IgE and high eosinophilia, observe the clinical symptoms of patients and eosinophilic inflammation related indicators, achieve effective improvement of patient lung function and clinical symptoms, reduce eosinophils, serum total IgE and FeN0, FnN0 expression, obtain a new Chinese medicine formula with good improvement effect on the inflammation management of the whole airway, give full play to the advantages of traditional Chinese medicine in the treatment of bronchial asthma and better promote the development of traditional Chinese medicine. Summary of the invention

[0005] The purpose of the present invention is to provide a new Chinese medicine formula for treating allergic asthma. In the new Chinese medicine formula of the present invention, Ganoderma lucidum has the effects of replenishing qi and calming the mind, relieving cough and relieving asthma; Sophora flavescens clears away heat and dampness, dispels wind and kills insects; Radix licorice nourishes the spleen and stomach, replenishes qi and restores the pulse, and harmonizes various medicines; Rubia cordifolia cools blood and stops bleeding, and promotes blood circulation and removes blood stasis. The four herbs are used together to play the effects of replenishing qi and relieving asthma, clearing heat and dampness, and promoting blood circulation and removing blood stasis, and have a good therapeutic effect on allergic asthma; the present invention uses Ganoderma lucidum, Sophora flavescens, Radix licorice, and Rubia cordifolia as main ingredients, which can effectively relieve the symptoms of patients with allergic asthma, such as wheezing, coughing, chest tightness, etc., and improve the quality of life of patients; the present invention adopts natural Chinese medicinal materials, has little side effects on the human body, and is highly safe; the present invention can quickly relieve the symptoms of patients and shorten the treatment cycle.

[0006] In order to achieve the above-mentioned purpose, the technical scheme adopted by the present invention is as follows: a new Chinese medicine formula for treating allergic asthma, which comprises the following components in parts by weight: 10-60 parts of Ganoderma lucidum, 1-10 parts of Sophora flavescens, 1-15 parts of Glycyrrhiza uralensis, and 10-90 parts of Rubia cordifolia.

[0007] Preferably, the new Chinese medicine formula comprises the following components in parts by weight: 15-55 parts of Ganoderma lucidum, 2-8 parts of Sophora flavescens, 2-13 parts of Radix Glycyrrhizae Preparata, and 12-75 parts of Rubia cordifolia.

[0008] Preferably, the new Chinese medicine formula comprises the following components in parts by weight: 20-40 parts of Ganoderma lucidum, 4-8 parts of Sophora flavescens, 3-9 parts of Radix Glycyrrhizae Preparata, and 30-60 parts of Rubia cordifolia.

[0009] Furthermore, the new Chinese medicine formula also includes pharmaceutically acceptable excipients.

[0010] Furthermore, the auxiliary materials include one or more of starch, magnesium stearate and honey.

[0011] The present invention also provides a method for preparing a new Chinese medicine formula for treating allergic asthma, the preparation method comprising the following steps:

[0012] (1) Weigh appropriate amounts of Ganoderma lucidum, Sophora flavescens, Radix Glycyrrhizae Preparata, and Rubia cordifolia, wash them, and air-dry them;

[0013] (2) The above raw materials are crushed into fine powder, sieved through a mesh sieve, and put into capsules to obtain the Chinese medicine capsules of the present invention.

[0014] Furthermore, in step (2), the mesh size of the sieve is 80-100 mesh.

[0015] Furthermore, the dosage form can be prepared into decoction and pills.

[0016] The beneficial effects achieved by the present invention using the above structure are as follows: (1) The present invention uses Ganoderma lucidum, Sophora flavescens, Radix Glycyrrhizae Radix and Rubia cordifolia as main ingredients, which can effectively relieve the symptoms of patients with allergic asthma, such as wheezing, coughing, chest tightness, etc., and improve the quality of life of patients; (2) The present invention uses natural Chinese medicinal materials, which have little side effects on the human body and are highly safe; (3) The present invention can quickly relieve patients' symptoms and shorten the treatment cycle.

[0017] The present invention uses a new Chinese medicine formula as an effective ingredient for treating allergic asthma. The Chinese medicine ingredients interact with each other to produce higher energy efficiency. Among them, Ganoderma lucidum can replenish qi and calm the mind, relieve cough and asthma, regulate the human nervous system, relieve anxiety, insomnia, dreaminess and other symptoms, and put the human body in a relatively peaceful and tranquil state, which helps allergic asthma patients maintain a good mental state during the illness and avoid aggravation of the disease due to emotional fluctuations. It directly acts on the respiratory tract, relieves airway spasm, and relieves symptoms such as cough and wheezing. Sophora flavescens has the effects of clearing away heat and dampness, dispelling wind and killing insects. Sophora flavescens is cold in nature and can remove dampness and heat in the body. Allergic asthma is effective in Chinese medicine theory. Chinese medicine is often related to dampness and heat in the body. Sophora flavescens can effectively remove dampness and heat, creating a good internal environment for the treatment of allergic asthma; Roasted Licorice root has the effects of tonifying the spleen and stomach and replenishing Qi and restoring the pulse. Roasted Licorice root can coordinate the effects of other medicines such as Ganoderma lucidum, Sophora flavescens, and Rubia cordifolia, so that they can better play a synergistic role and jointly treat allergic asthma; Rubia cordifolia has the functions of cooling blood and stopping bleeding and promoting blood circulation and removing blood stasis. The cooling blood and stopping bleeding effect of Rubia cordifolia can effectively deal with the potential bleeding symptoms of respiratory mucosal bleeding, reduce various discomforts caused by blood heat, create a stable internal environment for the treatment of allergic asthma, promote the circulation of Qi and blood, and eliminate blood stasis in the body. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 Asthma Control Test score.

[0019] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0021] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0022] The experimental methods in the following examples are conventional methods unless otherwise specified; the experimental materials and test strains used in the following examples are purchased from commercial channels unless otherwise specified.

[0023] Example 1

[0024] A new Chinese medicine formula for treating allergic asthma

[0025] The new Chinese medicine formula comprises the following components in parts by weight: 20 parts of ganoderma lucidum, 8 parts of sophora flavescens, 6 parts of licorice root and 30 parts of madder root.

[0026] Wherein, the new Chinese medicine formula also includes pharmaceutically acceptable excipients.

[0027] Wherein, the auxiliary material is honey.

[0028] The present invention also provides a method for preparing a new Chinese medicine formula for treating allergic asthma, the preparation method comprising the following steps:

[0029] (1) Weigh appropriate amounts of Ganoderma lucidum, Sophora flavescens, Radix Glycyrrhizae Preparata, and Rubia cordifolia, wash them, and air-dry them;

[0030] (2) The above raw materials are crushed into fine powder, sieved through a mesh sieve, and put into capsules to obtain the Chinese medicine capsules of the present invention.

[0031] Wherein, the mesh size of the sieve in step (2) is 80-100 mesh.

[0032] The dosage form can be made into decoction and pills.

[0033] Example 2

[0034] A new Chinese medicine formula for treating allergic asthma

[0035] The new Chinese medicine formula comprises the following components in parts by weight: 40 parts of ganoderma lucidum, 6 parts of sophora flavescens, 9 parts of licorice root and 30 parts of madder root.

[0036] Wherein, the new Chinese medicine formula also includes pharmaceutically acceptable excipients.

[0037] Wherein, the auxiliary material is honey.

[0038] The present invention also provides a method for preparing a new Chinese medicine formula for treating allergic asthma, and the preparation method is carried out with reference to Example 1.

[0039] Example 3

[0040] A new Chinese medicine formula for treating allergic asthma

[0041] The new Chinese medicine formula comprises the following components in parts by weight: 40 parts of ganoderma lucidum, 6 parts of sophora flavescens, 9 parts of licorice root and 60 parts of madder root.

[0042] Wherein, the new Chinese medicine formula also includes pharmaceutically acceptable excipients.

[0043] Wherein, the auxiliary material is honey.

[0044] The present invention also provides a method for preparing a new Chinese medicine formula for treating allergic asthma, and the preparation method is carried out with reference to Example 1.

[0045] Experimental Example 1

[0046] Effect of a new Chinese medicine formula for the treatment of allergic asthma on patients

[0047] 12 patients with high IgE and high eosinophil asthma who met the inclusion criteria were selected and treated with the new formulation process drugs of Examples 1-3 of the present invention on the basis of standardized asthma treatment. They were randomly divided into 3 groups, 4 cases in each group, marked as Example 1-3 groups, and the course of treatment was 3 months. During this period, standardized asthma treatment was applied according to the asthma graded treatment plan. However, oral and intravenous medications, including other traditional Chinese medicine treatments, cannot be used. If used due to worsening of the condition, it is necessary to withdraw from observation. The clinical symptom scores of the patients before treatment and 3 months after treatment, including the asthma control test scores, were monitored separately.

[0048] Result analysis: Figure 1 As shown, the asthma control test score of the Example 3 group was the highest, followed by the Example 2 group and the Example 1 group.

[0049] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0050] The present invention and its embodiments are described above, and such description is not restrictive. The drawings show only one embodiment of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and embodiment similar to the technical solution without creativity, which should belong to the protection scope of the present invention.

Claims

1. A new Chinese medicine formula for treating allergic asthma, characterized in that: The new Chinese medicine formula comprises the following components in parts by weight: 10-60 parts of ganoderma lucidum, 1-10 parts of sophora flavescens, 1-15 parts of licorice root, and 10-90 parts of madder root.

2. A new Chinese medicine formula for treating allergic asthma according to claim 1, characterized in that: The new Chinese medicine formula comprises the following components in parts by weight: 15-55 parts of ganoderma lucidum, 2-8 parts of sophora flavescens, 2-13 parts of licorice root, and 12-75 parts of madder root.

3. A new Chinese medicine formula for treating allergic asthma according to claim 2, characterized in that: The new Chinese medicine formula comprises the following components in parts by weight: 20-40 parts of ganoderma lucidum, 4-8 parts of sophora flavescens, 3-9 parts of licorice root, and 30-60 parts of madder root.

4. A new Chinese medicine formula for treating allergic asthma according to claim 3, characterized in that: The new Chinese medicine formula also includes pharmaceutically acceptable excipients.

5. A new Chinese medicine formula for treating allergic asthma according to claim 4, characterized in that: The auxiliary materials include one or more of starch, magnesium stearate and honey.

6. A method for preparing the new Chinese medicine formula for treating allergic asthma according to claim 5, characterized in that: The preparation method comprises the following steps: (1) Weigh appropriate amounts of Ganoderma lucidum, Sophora flavescens, Radix Glycyrrhizae Preparata, and Rubia cordifolia, wash them, and air-dry them; (2) The above raw materials are crushed into fine powder, sieved through a mesh sieve, and put into capsules to obtain the Chinese medicine capsules of the present invention.

7. A new Chinese medicine formula for treating allergic asthma according to claim 6, characterized in that: The mesh size of the sieve in step (2) is 80-100 mesh.

8. A new Chinese medicine formula for treating allergic asthma according to claim 7, characterized in that: The dosage form can be prepared into decoction and pills.

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