Traditional Chinese medicine composition for treating rheumatism and rheumatoid bone impediment and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating rheumatism and rheumatoid bone impediment and a preparation method thereof. The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing the materials in the traditional Chinese medicine composition in parts by weight; all the materials in the traditional Chinese medicine composition are cleaned and dried; putting the dried materials into a crusher for crushing; the crushed materials are sieved, and qualified fine materials are obtained; all the fine materials are put into a stirring machine to be stirred and mixed to be uniform to prepare the traditional Chinese medicine composition. The problems that in the prior art, due to simple compatibility of Chinese herbal medicines, side effects are caused, the treatment effect cannot be maximized, and the side effects cannot be minimized are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating rheumatism and rheumatoid arthritis and a preparation method thereof. Background Art

[0002] In traditional Chinese medicine theory, rheumatoid arthritis is considered a disease caused by the invasion of wind and dampness into the joints, which is characterized by poor circulation of qi and blood and blocked meridians, leading to joint pain and swelling. Rheumatism and rheumatoid arthritis are a disease in traditional Chinese medicine, mainly manifested by symptoms such as joint pain, swelling, and stiffness, similar to rheumatoid arthritis in modern medicine. According to traditional Chinese medicine theory, rheumatoid arthritis belongs to the category of "arthritis syndrome", and its cause is mainly related to the invasion of evil spirits such as wind, cold, dampness, and heat, which leads to poor circulation of qi and blood and blocked meridians. Traditional Chinese medicine treatment of rheumatoid arthritis focuses on syndrome differentiation and treatment, and adopts corresponding treatment methods according to the patient's specific symptoms.

[0003] Traditional Chinese medicine divides arthralgia into many types, including wind arthralgia, cold arthralgia, damp arthralgia, heat arthralgia and bone arthralgia, and each type of joint manifestation is different. When treating, traditional Chinese medicine will adopt different treatment methods according to the understanding of the cause and pathogenesis, such as dispelling wind and cold, dispelling dampness and unblocking meridians, clearing heat and detoxifying, and promoting blood circulation and removing blood stasis.

[0004] Therefore, there is an urgent need to provide a new method and idea in the treatment of bone arthritis caused by rheumatoid arthritis. Summary of the invention

[0005] To this end, the present invention provides a Chinese medicine composition for treating rheumatism and rheumatoid arthritis and a preparation method thereof, so as to overcome the side effects caused by the simple compatibility of Chinese herbal medicines in the prior art and the problem that the therapeutic effect cannot be maximized and the side effects cannot be minimized.

[0006] To achieve the above purpose, the present invention provides a Chinese medicine composition for treating rheumatism and rheumatoid arthritis on one hand, which is prepared from the following raw materials: processed Strychnos nux vomica, ephedra, angelica, safflower, eucommia, Qiannianjian, Difengpi, earthworm, Eucommia sinensis, Cibotium bark, Achyranthes bidentata, cinnamon twig, Gentiana macrophylla, Chuanduan, vinegar frankincense, vinegar myrrh, processed Chuanwu, processed Caowu, clematis, Notopterygium wilfordii, Angelica dahurica, Sanguisorba officinalis, Corydalis yanhusuo, Atractylodes macrocephala, papaya, Saposhnikovia divaricata, whole insect, Gastrodia elata, Cyperus rotundus, Snake, Millettia spatholobi, natural copper, licorice, Herba Lycopodii, Herba Penisulae, Herba Cyperi, and Tribulus terrestris.

[0007] Further, the Chinese medicine composition comprises the following components in parts by weight: 10-15 parts of processed Strychnos nux vomica, 5-15 parts of ephedra, 2-5 parts of angelica, 2-5 parts of safflower, 2-5 parts of eucommia bark, 2-5 parts of millennium jian, 2-5 parts of ground maple bark, 2-10 parts of earthworm, 2-10 parts of earthworm, 2-10 parts of dog spine, 2-10 parts of Achyranthes bidentata, 2-5 parts of cassia twig, 2-5 parts of gentiana macrophylla, 2-5 parts of chuanduan, 2-5 parts of vinegar frankincense, 2-5 parts of vinegar myrrh, 10 parts of processed Chuanwu -3 parts, 1-3 parts of processed Aconitum, 2-5 parts of Clematis, 2-5 parts of Notopterygium, 2-5 parts of Angelica dahurica, 1-3 parts of Sanguisorba officinalis, 2-5 parts of Corydalis, 2-5 parts of Atractylodes, 2-5 parts of Chaenomeles sinensis, 2-5 parts of Saposhnikovia divaricata, 1-3 parts of whole insect, 1-3 parts of Gastrodia elata, 2-5 parts of Cyperus rotundus, 2-5 parts of Agkistrodon acutus, 2-5 parts of Millettia reticulata, 2-5 parts of natural copper, 2-5 parts of Licorice, 2-5 parts of Lycopodiella cuneata, 2-5 parts of Herba Polygoni Multiflori, 2-5 parts of Perianthium, and 2-5 parts of Tribulus terrestris.

[0008] Further, the Chinese medicine composition comprises the following components in parts by weight: 12 parts of processed Strychnos nux vomica, 10 parts of ephedra, 3 parts of angelica, 3 parts of safflower, 3 parts of Eucommia ulmoides, 3 parts of Qiannianjian, 3 parts of Radix Glehniae, 3 parts of Pheretima, 3 parts of Earthworm, 6 parts of Eupolyphaga sinensis, 6 parts of Cibotium bark, 6 parts of Achyranthes bidentata, 3 parts of cinnamon twig, 3 parts of Gentiana macrophylla, 3 parts of Chuanduan, 3 parts of vinegar frankincense, 3 parts of vinegar myrrh, 2 parts of processed Chuanwu, 2 parts of processed Kusnezoffii, 3 parts of Clematis, 3 parts of Notopterygium wilfordii, 3 parts of Duhuo, 2 parts of Sanguisorba officinalis, 3 parts of Corydalis yanhusuo, 3 parts of Atractylodes macrocephala, 23 parts of papaya, 3 parts of Saposhnikovia divaricata, 2 parts of whole worm, 2 parts of Gastrodia elata, 3 parts of Cyperus rotundus, 3 parts of Agkistrodon acutus, 3 parts of Millettia reticulata, 3 parts of natural copper, 3 parts of Licorice, 3 parts of Lycopodiella cuneata, 3 parts of Herba spatholobi, 3 parts of Perianthium spatholobi, and 3 parts of Tribulus terrestris.

[0009] Furthermore, the dosage form of the Chinese medicine composition includes large honey pills, water honey pills, tablets, capsules,

[0010] Another aspect of the present invention provides a method for preparing the above-mentioned Chinese medicine composition, comprising:

[0011] Step S1, weighing each material in the traditional Chinese medicine composition according to weight;

[0012] Step S2, washing and drying the materials in the traditional Chinese medicine composition;

[0013] Step S3, placing the dried materials into a grinder for crushing;

[0014] Step S4, sieving the crushed materials to obtain qualified fine materials;

[0015] Step S5: putting all the fine materials into a mixer and stirring and mixing them to obtain a Chinese medicine composition.

[0016] Furthermore, the moisture content of each of the materials after drying is 10wt%-15wt%.

[0017] Furthermore, the mesh size of the sieve used in the sieving process is 80-120 meshes.

[0018] Compared with the prior art, the invention has the beneficial effects of being able to dispel wind and dampness, activate blood circulation and dredge collaterals, dispel cold and relieve pain. It is used for arthralgia caused by wind, cold and dampness blocking the collaterals, blood stasis blocking the collaterals, with symptoms of waist and leg pain, limb numbness, flexion and extension difficulties, joint cold pain, tingling or severe pain; rheumatoid arthritis and rheumatoid arthritis with the above symptoms.

[0019] The present invention is an innovative multi-component synergistic formula carefully designed based on traditional Chinese medicine theory, and is specially designed for the treatment of rheumatoid arthritis. Through the reasonable combination of monarch, minister, assistant and envoy, it achieves the comprehensive therapeutic effects of dispelling wind and dampness, promoting blood circulation and unblocking collaterals, and dispelling cold and relieving pain, thereby effectively alleviating the main symptoms of patients with rheumatoid arthritis.

[0020] In order to enhance the therapeutic effect, the auxiliary drug ephedra assists in enhancing the therapeutic effect by promoting blood circulation and removing blood stasis, regulating the immune system, and promoting the improvement of the condition. It promotes the circulation of qi and blood, dredges the meridians, and thus relieves joint pain and swelling.

[0021] In addition, the present invention also contains Radix Glehniae, Pheretima, and Eupolyphaga, which are adjuvants with anti-edema and analgesic effects, and can further relieve joint pain and swelling, and improve the quality of life of patients. These drugs can dispel cold and relieve pain, and bring additional comfort to patients.

[0022] In order to make the medicinal properties of the whole formula more harmonious and unified, licorice is added to it to play the role of harmonizing the various medicines and alleviating the medicinal properties. Licorice can balance the medicinal properties of various medicines and ensure the coordination and stability of the whole formula.

[0023] The present invention carefully combines up to thirty-seven kinds of herbs through the synergistic effect of multiple components, realizes the synergistic effect between drugs, forms a complex treatment network, and can treat rheumatoid arthritis in an all-round and multi-angle manner. Personalized treatment fully takes into account the unique constitution and condition differences of each patient, and customizes a personalized treatment plan for each patient through syndrome differentiation and treatment, ensuring the accuracy and efficiency of the treatment. The combined application of multiple herbs organically combines herbs with different effects, which not only brings out the unique therapeutic effects of various herbs, but also avoids the side effects that may be caused by a single herb, achieving the maximization of the treatment effect and the minimization of the side effects.

[0024] In traditional Chinese medicine theory, the nature, flavor and meridians of a drug are the key to its effectiveness. The drugs in this formula cover a variety of flavors, such as pungent, bitter, sweet and salty. These different flavors can act on different meridians and organs, thereby exerting an overall therapeutic effect. For example, pungent drugs can promote qi and blood circulation, bitter drugs can clear away heat and dampness, sweet drugs can nourish and harmonize the middle, and salty drugs can soften and disperse nodules. Through such flavor combinations, this prescription can better regulate the balance of yin and yang in the human body and achieve the purpose of treating rheumatoid arthritis.

[0025] This Chinese medicine prescription has shown remarkable innovation in terms of multi-component synergy, personalized treatment, combined application of multiple herbs, and innovation of Chinese medicine preparations, providing a new method and idea for the treatment of rheumatoid arthritis. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 The present invention is a flowchart of a method for preparing a Chinese medicine composition for treating rheumatism and rheumatoid arthritis of the bone. DETAILED DESCRIPTION

[0027] In order to make the objects and advantages of the present invention more clearly understood, the present invention is further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0028] For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0029] Prepared Strychnos nux vomica has the effects of dredging meridians and relieving pain, dispersing nodules and reducing swelling. Ephedra has the effects of sweating and dispersing cold, ventilating the lungs and relieving asthma, and promoting diuresis and reducing swelling. Angelica sinensis has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. Safflower has the effects of activating blood circulation and dredging menstruation, dispersing blood stasis and relieving pain. Eucommia ulmoides has the effects of nourishing the liver and kidneys, strengthening tendons and bones, and calming the fetus. Qiannianjian has the effects of removing rheumatism and strengthening tendons and bones. Difengpi has the effects of removing wind and dampness, promoting qi and relieving pain. Pheretima has the effects of clearing heat and calming convulsions, dredging meridians, relieving asthma, and promoting diuresis. Eupolyphaga sinensis has the effects of breaking blood and removing blood stasis, and connecting tendons and bones. Cibotium barometz has the effects of removing rheumatism, nourishing the liver and kidneys, and strengthening the waist and knees. Achyranthes bidentata has the effects of removing blood stasis and dredging menstruation, nourishing the liver and kidneys, strengthening tendons and bones, promoting diuresis and relieving stranguria, and guiding blood downward. Cinnamon twig has the effects of sweating and relieving muscles, warming and unblocking the meridians, assisting yang and transforming qi, and balancing and descending qi. Qinjiao has the effects of removing rheumatism, clearing damp-heat, relieving pain and relieving deficiency heat. Dipsacus has the effects of nourishing the liver and kidney, strengthening tendons and bones, healing fractures and stopping metrorrhagia. Vinegar frankincense has the effects of promoting blood circulation and relieving pain, reducing swelling and promoting tissue regeneration. Vinegar myrrh has the effects of dispersing blood stasis and relieving pain, reducing swelling and promoting tissue regeneration. Processed Chuanwu has the effects of removing wind and dampness, warming the meridians and relieving pain. Processed Caowu has the effects of removing wind and dampness, warming the meridians and relieving pain. Clematidis has the effects of removing rheumatism and unblocking the meridians. Qianghuo has the effects of dispelling cold, removing wind and dampness, and relieving pain. Duhuo has the effects of removing wind and dampness, relieving pain and relieving arthralgia. Xuejie has the effects of promoting blood circulation and relieving pain, removing blood stasis and stopping bleeding, promoting tissue regeneration and healing sores. Yuanhu has the effects of promoting blood circulation, promoting qi and relieving pain. Atractylodes has the effects of drying dampness and strengthening the spleen, removing wind and cold, and improving eyesight. Papaya has the effects of relaxing tendons and activating collaterals, harmonizing the stomach and removing dampness. Saposhnikovia divaricata has the effects of dispelling wind and relieving exterior symptoms, relieving dampness and relieving pain, and stopping spasms. Quanchong has the effects of calming wind and calming spasms, unblocking meridians and relieving pain, and attacking toxins and dispersing knots. Gastrodia elata has the effects of calming wind and stopping spasms, calming liver yang, dispelling wind and unblocking meridians. Cyperus rotundus has the effects of soothing the liver and relieving depression, regulating qi and relieving fullness, regulating menstruation and relieving pain. Black-striped snake has the effects of dispelling wind, unblocking meridians, and stopping spasms. Millettia reticulata has the effects of promoting blood circulation and replenishing blood, regulating menstruation and relieving pain, and relaxing tendons and activating collaterals. Natural copper has the effects of dispersing blood stasis and relieving pain, and connecting tendons and setting bones. Licorice has the effects of tonifying the spleen and replenishing qi, clearing heat and detoxifying, removing phlegm and relieving cough, relieving acute pain, and harmonizing various medicines. Stretching tendon grass has the effects of dispelling wind and dampness, relaxing tendons and activating collaterals. Penetrating bone grass (muscle grass) has the effects of clearing heat and detoxifying, cooling blood and reducing swelling. Guanjin (old geranium) has the effects of dispelling rheumatism, unblocking meridians, and stopping diarrhea and dysentery. Achyranthes bidentata has the effects of removing blood stasis and promoting menstruation, nourishing the liver and kidney, strengthening tendons and bones, promoting urination and relieving stranguria, and guiding blood downward. Tribulus terrestris has the effects of calming the liver and relieving depression, promoting blood circulation and dispelling wind, improving eyesight, and relieving itching.

[0030] In the embodiment of the present invention, the monarch drug is Strychnos nux vomica, the minister drug is Ephedra sinica, the adjuvant drugs include safflower, Qiannianjian, Difengpi, Eupolyphaga sinensis, Gentiana macrophylla, frankincense, myrrh, Chuanwu, Caowu, Clematis chinensis, Notopterygium wilfordii, Angelica dahurica, Saposhnikovia divaricata, Quanchong, Gastrodia elata, Black-striped snake, Stretching tendon grass, Guanjin, the messenger drugs include Angelica sinensis, Eucommia bark, Pheretima ulmoides, Cibotium barometz, Achyranthes bidentata, Cinnamomum cassia, Chuanduan, Sanguisorba officinalis, Corydalis yanhusuo, Atractylodes macrocephala, Chaenomeles sinensis, Cyperus rotundus, Millettia spatholobi, Natural copper, Licorice, Penisula oleracea (muscle grass), Tribulus terrestris; the monarch drug Strychnos nux vomica is the drug that plays a major therapeutic role on the main symptom or main disease of the prescription in the prescription, which embodies the main attack direction of the prescription, and its medicinal effect It is the first in the prescription and is an indispensable medicine in the prescription. The minister medicine ephedra is a medicine that assists the monarch medicine to strengthen the treatment of the main disease and main symptoms. The meaning of adjuvant medicine is: first, it is an adjuvant medicine, which is used to treat minor and concurrent symptoms; second, it is an adjuvant medicine, which is used to eliminate or reduce the toxicity or strength of the monarch medicine and minister medicine; third, it is an anti-adjuvant medicine, that is, according to the needs of the disease, the medicine with opposite medicinal properties to the monarch medicine but which can play a complementary role in treatment is used; the meaning of guiding medicine is: first, it is a guiding medicine, which guides the medicines in the prescription directly to the diseased area; second, it is a harmonizing medicine, that is, it harmonizes the effects of various medicines and makes them work together to eliminate evil. For example, Achyranthes bidentata and licorice are often used as guiding medicines in the prescription.

[0031] Embodiment 1,

[0032] Prepared from the following raw materials:

[0033] 400g of processed Strychnos nux vomica, 250g of ephedra, 40g of angelica, 50g of safflower, 40g of Eucommia bark, 40g of Qiannianjian, 40g of Difengpi, 40g of earthworm, 60g of earthworm, 60g of dog spine, 40g of Achyranthes bidentata, 40g of cinnamon twig, 40g of Gentiana macrophylla, 40g of Chuanduan, 40g of vinegar frankincense, 40g of vinegar myrrh, 40g of processed Chuanwu, 40g of processed Caowu, 40g of Clematis chinensis g, Qianghuo 40g, Duhuo 40g, Xuejie 15g, Yuanhu 40g, Atractylodes 40g, Papaya 40g, Saposhnikovia 40g, Quanchong 10g, Gastrodia 10g, Cyperus 40g, Agkistrodon 30g, Millettia reticulata 40g, Natural Copper 40g, Licorice 40g, Achyranthes bidentata 40g, Bone-penetrating Grass 40g, Geranium 40g, Tribulus terrestris 40g.

[0034] A method for preparing large honey pills of a traditional Chinese medicine composition for treating rheumatism and rheumatoid arthritis, the method comprising:

[0035] Grind the above medicinal materials into fine powder (80 mesh) according to the proportion, mix them evenly and set aside;

[0036] Refining honey: weigh a certain amount of honey and heat it to boiling (if there are impurities, filter them out), continue to refine it to the level of refined honey, remove the floating foam with gloss;

[0037] Mix the medicine: Mix the refined honey with the medicinal powder, stirring until it can be kneaded into a ball without sticking to the hands;

[0038] Pill making: Divide the mixed ingredients into small portions and knead them into balls. Each pill is 6g and the daily dosage is 6g.

[0039] Drying: Dry the prepared large honey pills at a temperature below 80°C;

[0040] Packaging: Package the dried large honey pills to maintain their stability.

[0041] Embodiment 2,

[0042] Prepared from the following raw materials:

[0043] 200g of processed Strychnos nux vomica, 200g of ephedra, 20g of angelica, 30g of safflower, 20g of Eucommia bark, 25g of millennium jian, 25g of maple bark, 25g of earthworm, 40g of earthworm, 40g of dog spine, 20g of Achyranthes bidentata, 25g of cassia twig, 25g of Gentiana macrophylla, 20g of Chuanduan, 25g of vinegar frankincense, 25g of vinegar myrrh, 20g of processed Chuanwu, 20g of processed Caowu, 20g of Clematis chinensis 0g, Qianghuo 20g, Duhuo 20g, Xuejie 10g, Yuanhu 20g, Atractylodes 20g, Papaya 20g, Saposhnikovia 20g, Quanchong 5g, Gastrodia 5g, Cyperus 20g, Agkistrodon 20g, Millettia reticulata 20g, Natural Copper 20g, Licorice 30g, Achyranthes bidentata 20g, Bone-penetrating Grass (Bone-penetrating Grass) 20g, Geranium 20g, Tribulus terrestris 20g.

[0044] A method for preparing water-honeyed pills of a traditional Chinese medicine composition for treating rheumatism and rheumatoid arthritis, the method comprising:

[0045] Grind the above medicinal materials into fine powder (80 mesh) according to the proportion, mix them evenly and set aside;

[0046] Refining honey: weigh a certain amount of honey and heat it to boiling (if there are impurities, filter them out), continue to refine it to the level of refined honey, remove the floating foam with gloss;

[0047] Mix the processed medicinal material powder with refined honey and appropriate amount of water, and stir into a plastic medicine ball. Pill making;

[0048] Divide the pill into small portions and roll each portion into a ball. The size depends on the needs, usually 0.3g, and the daily dose is 0.6g.

[0049] Drying and packaging: The prepared water-honey pills are dried (below 80°C) and packaged with appropriate packaging materials.

[0050] Embodiment 3,

[0051] Prepared from the following raw materials:

[0052] 400g of processed Strychnos nux vomica, 250g of ephedra, 40g of angelica, 50g of safflower, 40g of Eucommia bark, 40g of Qiannianjian, 40g of Difengpi, 40g of earthworm, 60g of Eupolyphaga sinensis, 60g of Cibotium barometz, 40g of Achyranthes bidentata, 40g of cinnamon twig, 40g of Gentiana macrophylla, 40g of Chuanduan, 40g of vinegar frankincense, 40g of vinegar myrrh, 40g of processed Chuanwu, 40g of processed Caowu, 40g of Clematis chinensis g, Qianghuo 40g, Duhuo 40g, Xuejie 15g, Yuanhu 40g, Atractylodes 40g, Papaya 40g, Saposhnikovia 40g, Quanchong 10g, Gastrodia 10g, Cyperus 40g, Agkistrodon 30g, Millettia reticulata 40g, Natural Copper 40g, Licorice 40g, Achyranthes bidentata 40g, Bone-penetrating Grass 40g, Geranium 40g, Tribulus terrestris 40g.

[0053] A method for preparing tablets of a Chinese medicine composition for treating rheumatism and rheumatoid arthritis, the method comprising:

[0054] Grind the above medicinal materials into fine powder (100 mesh) according to the proportion, mix them evenly and set aside;

[0055] Granulation: Wet granulation is adopted. The powder is put into a trough mixer and run for 15 minutes. Then 70% ethanol is added and the mixture is stirred evenly to form a soft material. A 16-mesh screen is applied to the swing granulator. The stirred soft material is added and the machine is started to form granules.

[0056] Drying: Dry the granules at 50-60℃ for 2.5 hours;

[0057] Whole grain: Use 14-mesh and 40-mesh screens to remove large and fine particles from the dried particles, which are the particles that meet the requirements;

[0058] Total mixing: put the granules and magnesium stearate into the mixer, lock the feed port, and mix for 30 minutes;

[0059] Tableting: Tablets are pressed according to the required tablet weight, hardness and thickness. Each tablet weighs 0.4g and the daily dosage is 0.4g.

[0060] Packaging: Qualified tablets are counted and packaged, usually in foil or bottles.

[0061] Embodiment 4,

[0062] Prepared from the following raw materials:

[0063] 400g of processed Strychnos nux vomica, 250g of ephedra, 40g of angelica, 50g of safflower, 40g of Eucommia bark, 40g of Qiannianjian, 40g of Difengpi, 40g of earthworm, 60g of Eupolyphaga sinensis, 60g of Cibotium barometz, 40g of Achyranthes bidentata, 40g of cinnamon twig, 40g of Gentiana macrophylla, 40g of Chuanduan, 40g of vinegar frankincense, 40g of vinegar myrrh, 40g of processed Chuanwu, 40g of processed Caowu, 40g of Clematis chinensis g, Qianghuo 40g, Duhuo 40g, Xuejie 15g, Yuanhu 40g, Atractylodes 40g, Papaya 40g, Saposhnikovia 40g, Quanchong 10g, Gastrodia 10g, Cyperus 40g, Agkistrodon 30g, Millettia reticulata 40g, Natural Copper 40g, Licorice 40g, Achyranthes bidentata 40g, Bone-penetrating Grass 40g, Geranium 40g, Tribulus terrestris 40g.

[0064] A method for preparing capsules of a Chinese medicine composition for treating rheumatism and rheumatoid arthritis, the method comprising:

[0065] Grind the above medicinal materials into fine powder (100 mesh) according to the proportion, mix them evenly and set aside;

[0066] Granulation: Wet granulation is adopted. The powder is put into a trough mixer and run for 15 minutes. Then 85% ethanol is added and the mixture is stirred evenly to form a soft material. A 16-mesh screen is applied to the swing granulator. The stirred soft material is added and the machine is started to form granules.

[0067] Drying: Dry the granules at 50-60℃ for 2.5 hours;

[0068] Whole grain: Use 14-mesh and 40-mesh screens to remove large and fine particles from the dried granules, which are the granules that meet the requirements.

[0069] Encapsulation: Put the dried granules into size 0 capsules, polish them, and each capsule contains 0.4g. The daily dosage is 0.4g.

[0070] Packaging: Qualified capsules are counted and packaged, usually in aluminum foil or bottles.

[0071] Example 1 Clinical efficacy observation

[0072] Case 1:

[0073] Patient: Wang, male, 64 years old;

[0074] Diagnosis: Rheumatoid arthritis;

[0075] Chief complaint: intermittent pain in both knee joints for half a year, aggravated for 10 days;

[0076] Condition: The patient had intermittent pain in both knees for half a year, which worsened for 10 days. The pain was migratory, the skin temperature of both knees was increased, tenderness was obvious, and there was slight swelling.

[0077] Physical examination: T36.3℃, P84 times / min, R20 times / min, BP135 / 88mmHg, clear consciousness, normal development, walked into the consulting room, self-positioned, and cooperated in the physical examination. There is no yellowing of the skin and mucous membranes of the whole body, and no superficial lymph node enlargement. There is no cyanosis of the lips, no congestion of the pharynx, no enlargement of the tonsils, soft neck, centered trachea, and no enlargement of the thyroid gland. The breath sounds of both lungs are clear, and no dry or wet rales are heard on auscultation of both lungs. The heart sounds are strong, the heart rate is 80 beats / min, the rhythm is regular, and no pathological murmurs are heard in the auscultation areas of the valves. The abdomen is flat and soft, there is no tenderness or rebound pain in the abdomen, and the bowel sounds are normal. The knee joints are obviously tender, the skin temperature is increased, and there is slight swelling.

[0078] Auxiliary examinations: antistreptolysin “○” 403.2 IU / ml; rheumatoid factor 12 I U / ml; high-sensitivity C-reactive protein 9.3 mg / L↑; erythrocyte sedimentation rate 35 mm / h.

[0079] Treatment method and situation: After seeing the doctor, the patient was given the Chinese medicine preparation prepared in Example 1 for treatment. After 3 weeks of treatment, the symptoms were significantly relieved, and there was no joint pain after 50 days, which means the patient was cured.

[0080] Treatment results: The patient was cured after 50 days of treatment with Chinese herbal medicine.

[0081] Case 2:

[0082] Patient: Qiu, male, 56 years old;

[0083] Diagnosis: Rheumatoid arthritis;

[0084] Chief complaint: intermittent pain in both ankle joints for 4 weeks, aggravated for 2 days;

[0085] Condition: The patient had intermittent pain in both ankle joints for 4 weeks, which worsened for 2 days. The pain was migratory and aggravated in rainy weather. The joints are now obviously tender but no obvious deformation is observed.

[0086] Physical examination: T36.1℃, P77 times / min, R22 times / min, BP120 / 68mmHg, clear consciousness, normal development, walked into the consulting room, self-positioned, and cooperated in the physical examination. There is no yellowing of the skin and mucous membranes of the whole body, and no superficial lymph node enlargement. There is no cyanosis of the lips, no congestion of the pharynx, no enlargement of the tonsils, soft neck, neutered trachea, and no enlargement of the thyroid gland. The breath sounds of both lungs are clear, and no dry or wet rales are heard on auscultation of both lungs. The heart sounds are strong, the heart rate is 77 times / min, the rhythm is regular, and no pathological murmurs are heard in the auscultation areas of the valves. The abdomen is flat and soft, there is no tenderness or rebound pain in the abdomen, and the bowel sounds are normal. The knee joints are obviously tender to touch, and no deformation is seen.

[0087] Auxiliary examinations: antistreptolysin “○” 462.8 IU / ml; rheumatoid factor 13 I U / ml; high-sensitivity C-reactive protein 7.8 mg / L↑; erythrocyte sedimentation rate 42 mm / h.

[0088] Treatment method and situation: After seeing the doctor, the patient was given the Chinese medicine preparation prepared in Example 1 for treatment. After 2 weeks of treatment, the symptoms were significantly relieved, and there was no joint pain after 30 days, which means the patient was cured.

[0089] Treatment results: The patient was cured after 30 days of treatment with Chinese herbal medicine.

[0090] Case 3:

[0091] Patient: Geng, male, 48 years old;

[0092] Diagnosis: Rheumatoid arthritis;

[0093] Chief complaint: intermittent pain in both knee joints for 3 weeks, aggravated for 1 day;

[0094] Condition: The patient had intermittent pain in both knees for 3 weeks, which worsened for 1 day. The pain was migratory and symmetrical. The joints were obviously tender and the skin temperature was elevated.

[0095] Physical examination: T36.4℃, P86 times / min, R19 times / min, BP138 / 90mmHg, clear consciousness, normal development, walked into the consulting room, self-positioned, and cooperated in the physical examination. There is no yellowing of the skin and mucous membranes of the whole body, and no superficial lymph node enlargement. There is no cyanosis of the lips, no congestion of the pharynx, no enlargement of the tonsils, soft neck, neutered trachea, and no enlargement of the thyroid gland. The breath sounds of both lungs are clear, and no dry or wet rales are heard on auscultation of both lungs. The heart sounds are strong, the heart rate is 86 times / min, the rhythm is regular, and no pathological murmurs are heard in the auscultation areas of the valves. The abdomen is flat and soft, there is no tenderness or rebound pain in the abdomen, and the bowel sounds are normal. There is obvious tenderness in both knee joints and the skin temperature is elevated.

[0096] Auxiliary examinations: antistreptolysin “○” 503.6.8I U / ml; rheumatoid factor 9I U / ml; high-sensitivity C-reactive protein 12.5mg / L↑; erythrocyte sedimentation rate 26mm / h.

[0097] Treatment method and situation: After seeing the doctor, the patient was given the Chinese medicine preparation prepared in Example 1 for treatment. After 2 weeks of treatment, the symptoms were significantly relieved, and there was no joint pain after 25 days, which means the patient was cured.

[0098] Treatment results: The patient was cured after 25 days of treatment with Chinese herbal medicine.

[0099] Case 4:

[0100] Patient: Jiang Moumou, female, 60 years old;

[0101] Diagnosis: Rheumatoid arthritis;

[0102] Chief complaint: Pain in both finger joints for 1 month, aggravated for 3 days.

[0103] Medical condition: The patient developed pain in multiple joints throughout the body one month ago. The pain was wandering, especially in the hand joints. The joints felt slightly stiff and tender, and the patient was usually afraid of wind and cold.

[0104] Physical examination: T36.2℃, P80 times / min, R20 times / min, BP120 / 80mmHg, clear consciousness, normal development, walked into the consulting room, self-positioned, and cooperated in the physical examination. There is no yellowing of the skin and mucous membranes of the whole body, and no superficial lymph node enlargement. There is no cyanosis of the lips, no congestion of the pharynx, no enlargement of the tonsils, soft neck, neutered trachea, and no enlargement of the thyroid gland. The breath sounds of both lungs are clear, and no dry or wet rales are heard on auscultation of both lungs. The heart sounds are strong, the heart rate is 80 beats / min, the rhythm is regular, and no pathological murmurs are heard in the auscultation areas of each valve. The abdomen is flat and soft, there is no tenderness or rebound pain in the abdomen, and the bowel sounds are normal.

[0105] Auxiliary examinations: white blood cells 3.94×10^9 / L↓; antistreptolysin “○” 96.6IU / ml; rheumatoid factor 71.9IU / ml; high-sensitivity C-reactive protein 6.2mg / L↑; erythrocyte sedimentation rate 12mm / h.

[0106] Treatment method and situation: After seeing the doctor, the patient was given the Chinese medicine preparation prepared in Example 1 for treatment. After 2 weeks of treatment, the symptoms were significantly relieved, and after 1 month, there was no joint pain, that is, the patient was cured.

[0107] Treatment results: The patient was cured after 1 month of treatment with Chinese herbal medicine.

[0108] Case 5:

[0109] Patient: Huang Moumou, female, 43 years old;

[0110] Diagnosis: Rheumatoid arthritis;

[0111] Chief complaint: intermittent pain in the right finger joints for 2 weeks, aggravated for 1 day;

[0112] Medical condition: The patient developed pain in the right finger joints 2 weeks ago, accompanied by poor mobility, swelling, and obvious tenderness.

[0113] Physical examination: T36.4℃, P76 times / min, R18 times / min, BP132 / 85mmHg, clear consciousness, normal development, walked into the consulting room, self-positioned, and cooperated in the physical examination. There is no yellowing of the skin and mucous membranes of the whole body, and no superficial lymph node enlargement. There is no cyanosis of the lips, no congestion of the pharynx, no enlargement of the tonsils, soft neck, neutered trachea, and no enlargement of the thyroid gland. The breath sounds of both lungs are clear, and no dry or wet rales are heard on auscultation of both lungs. The heart sounds are strong, the heart rate is 76 times / min, the rhythm is regular, and no pathological murmurs are heard in the auscultation areas of each valve. The abdomen is flat and soft, there is no tenderness or rebound pain in the abdomen, and the bowel sounds are normal.

[0114] Auxiliary examinations: antistreptolysin “○” 59.2 IU / ml; rheumatoid factor 180.5 IU / ml↑; high-sensitivity C-reactive protein 27.2 mg / L↑.

[0115] Treatment method and situation: After seeing the doctor, the patient was given the Chinese medicine preparation prepared in Example 1 for treatment. After 2 weeks of treatment, the symptoms were significantly relieved, and after 1 month, there was no joint pain, that is, the patient was cured.

[0116] Treatment results: The patient was cured after 1 month of treatment with Chinese herbal medicine.

[0117] Case 6:

[0118] Patient: Hu, male, 61 years old;

[0119] Diagnosis: Rheumatoid arthritis;

[0120] Chief complaint: intermittent pain in the joints of both toes for 2 months, aggravated for 1 week;

[0121] Medical condition: The patient experienced pain and stiffness in both toe joints 2 months ago, which worsened over 1 week. The patient had difficulty in movement and obvious tenderness.

[0122] Physical examination: T36.6℃, P70 times / min, R21 times / min, BP128 / 75mmHg, clear consciousness, normal development, walked into the consulting room, self-positioned, and cooperated in the physical examination. There is no yellowing of the skin and mucous membranes of the whole body, and no superficial lymph node enlargement. There is no cyanosis of the lips, no congestion of the pharynx, no enlargement of the tonsils, soft neck, neutered trachea, and no enlargement of the thyroid gland. The breath sounds of both lungs are clear, and no dry or wet rales are heard on auscultation of both lungs. The heart sounds are strong, the heart rate is 70 times / min, the rhythm is regular, and no pathological murmurs are heard in the auscultation areas of each valve. The abdomen is flat and soft, there is no tenderness or rebound pain in the abdomen, and the bowel sounds are normal.

[0123] Auxiliary examinations: antistreptolysin “○” 55.3 IU / ml; rheumatoid factor 92.5 IU / ml↑; erythrocyte sedimentation rate 17 mm / h.

[0124] Treatment method and situation: After seeing the doctor, the patient was given the Chinese medicine preparation prepared in Example 1 for treatment. After 3 weeks of treatment, the symptoms were significantly relieved, and there was no joint pain after 40 days, which means the patient was cured.

[0125] Treatment outcome: The patient was cured after 40 days of treatment with Chinese herbal medicine.

[0126] So far, the technical solutions of the present invention have been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

[0127] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating rheumatism and rheumatoid arthritis, characterized in that: It is made from the following raw materials: processed Strychnos nux vomica, ephedra, angelica, safflower, eucommia, Qiannianjian, Difengpi, earthworm, earthworm, Cibotium bark, Achyranthes bidentata, cinnamon twig, Gentiana macrophylla, Chuanduan, vinegar frankincense, vinegar myrrh, processed Chuanwu, processed Caowu, clematis, Notopterygium wilfordii, Angelica dahurica, Sanguisorba officinalis, Corydalis yanhusuo, Atractylodes macrocephala, papaya, Saposhnikovia divaricata, whole insect, Gastrodia elata, Cyperus rotundus, Black-spotted snake, Millettia reticulata, natural copper, licorice, Herba Lycopodii, Herba Penicilliae, Herba Cyperi, and Tribulus terrestris.

2. The Chinese medicine composition for treating rheumatism and rheumatoid arthritis according to claim 1, characterized in that: The Chinese medicine composition comprises the following components in parts by weight: 10-15 parts of processed Strychnos nux vomica, 5-15 parts of ephedra, 2-5 parts of angelica, 2-5 parts of safflower, 2-5 parts of eucommia bark, 2-5 parts of millennium jian, 2-5 parts of ground maple bark, 2-10 parts of earthworm, 2-10 parts of earthworm, 2-10 parts of dog spine, 2-10 parts of Achyranthes bidentata, 2-5 parts of cassia twig, 2-5 parts of gentiana macrophylla, 2-5 parts of chuanduan, 2-5 parts of vinegar frankincense, 2-5 parts of vinegar myrrh, 1-3 parts of processed Chuanwu 1-3 parts, processed Aconitum kusnezoffii, 2-5 parts of Clematis, 2-5 parts of Notopterygium, 2-5 parts of Angelica dahurica, 1-3 parts of Sanguisorba officinalis, 2-5 parts of Corydalis, 2-5 parts of Atractylodes, 2-5 parts of Chaenomeles sinensis, 2-5 parts of Saposhnikovia divaricata, 1-3 parts of Whole Insect, 1-3 parts of Gastrodia elata, 2-5 parts of Cyperus rotundus, 2-5 parts of Agkistrodon acutus, 2-5 parts of Millettia spatholobi, 2-5 parts of Natural Copper, 2-5 parts of Licorice, 2-5 parts of Lycopodiella cuneata, 2-5 parts of Herba Polygoni Multiflori, 2-5 parts of Perianthium, and 2-5 parts of Tribulus terrestris.

3. The Chinese medicine composition for treating rheumatism and rheumatoid arthritis according to claim 2, characterized in that: The Chinese medicine composition has the following components in parts by weight: 12 parts of processed Strychnos nux vomica, 10 parts of ephedra, 3 parts of angelica, 3 parts of safflower, 3 parts of Eucommia ulmoides, 3 parts of Qiannianjian, 3 parts of Radix Glehniae, 3 parts of Pheretima, 3 parts of Earthworm, 6 parts of Eupolyphaga sinensis, 6 parts of Cibotium bark, 6 parts of Achyranthes bidentata, 3 parts of cinnamon twig, 3 parts of Gentiana macrophylla, 3 parts of Chuanduan, 3 parts of vinegar frankincense, 3 parts of vinegar myrrh, 2 parts of processed Chuanwu, 2 parts of processed Kusnezoffii, 3 parts of Clematis, 3 parts of Notopterygium wilfordii, 3 parts of Duhuo, 2 parts of Sanguisorba officinalis, 3 parts of Corydalis yanhusuo, 3 parts of Atractylodes macrocephala, 23 parts of papaya, 3 parts of Saposhnikovia divaricata, 2 parts of whole insect, 2 parts of Gastrodia elata, 3 parts of Cyperus rotundus, 3 parts of Snakehead acanthus, 3 parts of Millettia reticulata, 3 parts of natural copper, 3 parts of Licorice, 3 parts of Herba Lycopodii, 3 parts of Herba Penicilliae, 3 parts of Perianthium spatholobi, and 3 parts of Tribulus terrestris.

4. The Chinese medicine composition for treating rheumatism and rheumatoid arthritis according to claim 1, characterized in that: The dosage forms of the Chinese medicine composition include large honey pills, water-honey pills, tablets and capsules.

5. A method for preparing the Chinese medicine composition for treating rheumatism and rheumatoid arthritis of any one of claims 1 to 4, characterized in that: include: Step S1, weighing each material in the traditional Chinese medicine composition according to weight; Step S2, washing and drying the materials in the traditional Chinese medicine composition; Step S3, placing the dried materials into a grinder for crushing; Step S4, sieving the crushed materials to obtain qualified fine materials; Step S5: putting all the fine materials into a mixer and stirring and mixing them to obtain a Chinese medicine composition.

6. The preparation method according to claim 5, characterized in that: The moisture content of each of the materials after drying is 10wt%-15wt%.

7. The preparation method according to claim 5, characterized in that: The mesh number of the sieve for the sieving process is 80-120 meshes.

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