Urine calcium oxalate crystal detection device and use method thereof

Abstract

The invention discloses a urine calcium oxalate crystal detection device and a use method thereof, and relates to the technical field of medical detection equipment, the urine calcium oxalate crystal detection device comprises a collection structure, the collection structure is used for collecting urine, the collection structure comprises a first container and a second container, the first container is provided with a first port, the second container is provided with a second port and a third port, the first port is detachably connected with the second port. The detection structure is used for detecting the collected urine and comprises a third container, a fourth container and a sealing assembly, the third container is provided with a fourth port, the fourth port is detachably connected with the third port, the third container is filled with a reaction substance, the fourth container is arranged above the third container, the bottom end of the fourth container is open, and the sealing assembly is connected with the fourth container. The top end of the third container is open, a sealing assembly is arranged between the bottom end of the fourth container and the top end of the third container, and the fourth container is filled with an indole solution. The method has the advantages that convenient detection of calcium oxalate crystals is realized, and a patient can detect and observe the change of an illness state by himself / herself.

Description

Technical Field

[0001] The present invention relates to the technical field of medical detection equipment, and in particular to a urine calcium oxalate crystal detection device and a use method thereof. Background Art

[0002] Urine testing is a routine clinical examination item. Urine is also the most easily obtained body fluid and can reflect the health status of many aspects of the human body. The dry chemical urine analysis method is simple, rapid, and widely used in various hospitals. The calcium oxalate crystal test is used to evaluate the presence of calcium oxalate crystals in the urine to diagnose possible kidney stones or other urinary system diseases. The appearance of calcium oxalate crystals in urine may indicate abnormal metabolism of oxalate and calcium in the body, and high concentrations of oxalate and calcium ions in the urine, which may be caused by eating habits, metabolic disorders, or renal excretion dysfunction. If not treated in time, it may lead to the formation of kidney stones, causing symptoms such as low back pain and hematuria.

[0003] At present, when detecting calcium oxalate crystals in urine, patients usually go to the hospital to collect urine through a urine cup and then hand it over to the testing equipment for testing. However, a large number of patients need to collect urine in the hospital. The hospital's collection equipment is simple and easy to spill, which seriously damages the patient's medical experience. The test results can only be understood by professional doctors. With the improvement of people's living standards, people's awareness of health management continues to increase. People hope to be able to monitor their health indicators in time at home. The existing testing equipment is large in size, and the calcium oxalate crystal detection method relies on advanced chromatographs or mass spectrometers, which are only suitable for hospital scenes. There are also some devices for urine testing at home on the market, but they cannot detect the concentration of calcium oxalate crystals in urine. The incidence and recurrence rate of kidney stones remain high, and there is a lack of early screening methods and postoperative monitoring methods. Therefore, there is a need for a device that can enable patients to detect calcium oxalate crystals in urine by themselves in community hospitals or at home, so that patients can monitor their own changes in their condition. Summary of the invention

[0004] In order to solve the above technical problems, the present invention provides a urine calcium oxalate crystal detection device and a method of using the same, which realizes the convenient detection of calcium oxalate crystals and allows patients to detect changes in their condition in a community hospital or at home.

[0005] The present invention provides a urine calcium oxalate crystal detection device, comprising: A collection structure for collecting urine, comprising a first container and a second container, wherein the first container has a first port, and the second container has a second port and a third port, wherein the first port and the second port are detachably connected, and when in use, the first port and the second port are connected together, and when a patient urinates in the first container, the urine flows into the second container along the first port and the second port.

[0006] A detection structure for detecting collected urine, the detection structure comprising a third container, a fourth container and a sealing component, the third container having a fourth port, the fourth port being detachably connected to the third port, the third container being filled with a reaction substance for reacting with urine to generate calcium oxalate crystals, the fourth container being arranged above the third container, the bottom end of the fourth container being open, the top end of the third container being open, a sealing component being arranged between the bottom end of the fourth container and the top end of the third container, the fourth container being filled with an indole solution for reacting with the calcium oxalate crystals in the third container, the sealing component being arranged so that the third container does not react with the indole solution in the fourth container before the reaction occurs, and the sealing component being openable to facilitate the indole solution in the fourth container to react with the reacted substance in the third container.

[0007] Preferably, a partition is provided in the second container, and the partition divides the second container into a first chamber and a second chamber, the first chamber is located above the second chamber, the second port and the third port are located in the first chamber, and a one-way valve is provided on the partition, and the liquid in the first chamber flows into the second chamber through the one-way valve, and the one-way valve isolates the initial urine and the mid-section urine, so that when the third container is tested, the mid-section urine in the first chamber is tested, so that the measured result is closer to the accurate value.

[0008] Preferably, the fourth container is a bag body, which is a disposable bag body and is thrown away after use, which is convenient and hygienic. The sealing component includes: The plate body is horizontally erected in the third container, and a first through hole is opened in the middle of the plate body.

[0009] The film is fixed to the side wall of the first through hole in its circumferential direction and is used to block the first through hole. The film is made of plastic. The position where the third container and the fourth container are connected can be sealed through the plate body and the film.

[0010] An airbag is arranged above the film, the airbag is filled with air, the airbag is connected to the film through a first heat-sealing tape, the airbag is connected to the bottom end of the fourth container through a second heat-sealing tape, the first heat-sealing tape and the second heat-sealing tape can be opened under the action of external force, similar to the bag of a squeeze mask in life, and the packaging structure between the liquid and the membrane cloth.

[0011] Preferably, the third container is a cylinder, and a suction structure is provided in the third container, and the suction structure is used to suck the liquid in the second container. The provision of the suction structure also avoids the problem of liquid backflow or liquid leakage when the second container and the third container are disassembled, making it more convenient for patients to perform detection operations.

[0012] Preferably, the suction structure comprises: The piston is sleeved in the third container and is slidably connected to the inner wall of the third container. The piston can slide up and down in the third container.

[0013] An electric telescopic rod is vertically arranged on the top of the piston, the top end of the electric telescopic rod is fixed to the plate body, and the electric telescopic rod is used to drive the piston to slide in the third container.

[0014] Preferably, a filter is horizontally arranged in the third container and is located below the piston, so as to prevent the reaction material in the third container from falling from the fourth port or the calcium oxalate crystals from being squeezed out when the suction structure pushes out the remaining solution after the reaction.

[0015] Preferably, a second through hole is formed at one end of the first container away from the first port, and a baffle is vertically provided on the second through hole. The baffle is hemispherical and can prevent urine from splashing when the patient retains urine.

[0016] A method for using a urine calcium oxalate crystal detection device comprises the following steps: The first port of the first container and the second port of the second container are connected together by threading.

[0017] The urine is retained in the first container through the second through hole, and the urine flows into the second container through the first port and the second port in sequence. The initial urine flows into the second cavity. After the second cavity is filled, the middle urine is retained in the first cavity. Then, the first port and the second port are separated and blocked with a rubber stopper.

[0018] The third port of the second container is connected to the fourth port of the third container, and the urine in the second container is sucked into the third container by using the suction structure. The urine reacts chemically with the reaction substance in the third container, and the urine reacts with oxalic acid and calcium chloride in the third container to obtain calcium oxalate crystals.

[0019] The third port and the fourth port are separated, and the third port and the fourth port are blocked with rubber plugs, and the third container is allowed to stand at room temperature for 15 minutes, and then the rubber plug of the fourth port is opened to push the remaining liquid in the third container out through the suction structure.

[0020] The fourth port was blocked, and the airbag was squeezed to open the first heat-sealing tape and the second heat-sealing tape, so that the indole solution in the fourth container flowed into the third container. After being fully mixed, the solution was allowed to stand at room temperature for 2 hours.

[0021] The approximate concentration of calcium oxalate crystals in the urine obtained in the third container is compared using a colorimetric card, because calcium oxalate reacts with the indole solution to produce a color change, and different colors correspond to different concentrations of calcium oxalate.

[0022] Preferably, the reaction mass includes 0.45 mg of oxalic acid and 27.75 mg of calcium chloride.

[0023] Compared with the prior art, the present invention discloses a urine calcium oxalate crystal detection device and a method for using the same, which has the following beneficial effects: When the device is used, it first collects the patient's urine through the collection structure, and then directly detects it through the detection structure connected to the collection structure, so as to obtain the result of the patient's condition change, and it is convenient to use. The device can realize the convenient detection of calcium oxalate crystals in urine. The patient can detect the concentration of calcium oxalate crystals in urine in a community hospital or at home without going to the hospital, which is convenient for the patient to monitor the changes in his or her condition. It is suitable for early screening or postoperative monitoring of kidney stones, and if it is necessary to further obtain an accurate concentration value, there is no need to go to the hospital to collect urine for re-testing. The third container can be directly taken for testing, which saves the process of queuing up for examination in the hospital, is fast and convenient, and does not require the patient to face the environment of the hospital toilet. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0025] Figure 1 It is a schematic diagram of the structure of the present invention.

[0026] Figure 2 It is a partial schematic diagram of the sealing assembly of the present invention.

[0027] Figure 3 It is a top view of the plate body of the present invention.

[0028] The meanings of the numbers in the figure are as follows: 1—collecting structure, 2—detection structure, 11—first container, 12—second container, 111—first port, 112—second through hole, 113—baffle, 114—handle, 121—second port, 122—third port, 123—partition, 124—first chamber, 125—second chamber, 126—check valve, 21—third container, 22—fourth container, 23—sealing assembly, 24—suction structure, 211—fourth port, 212—filter, 231—plate body, 232—first through hole, 233—film, 234—airbag, 241—piston, 242—electric telescopic rod. DETAILED DESCRIPTION

[0029] A specific implementation of the present invention is described in detail below in conjunction with the accompanying drawings, but it should be understood that the protection scope of the present invention is not limited by the specific implementation.

[0030] In the description of the present invention, it is to be understood that the terms “center”, “longitudinal”, “lateral”, “length”, “width”, “thickness”, “up”, “down”, “front”, “back”, “left”, “right”, “vertical”, “horizontal”, “top”, “bottom”, “inside”, “outside”, “axial”, “radial”, “circumferential”, etc., indicating orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, are only for the convenience of describing the technical solutions of the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0031] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the term "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection, it can be a mechanical connection, it can be an electrical connection, it can be a direct connection, it can be an indirect connection through an intermediate medium, and it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0032] In addition, in the description of the present invention, "plurality" means two or more than two. The terms "first" and "second" are used for descriptive purposes only and should not be understood to imply or suggest relative importance or implicitly indicate the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features.

[0033] Example 1 The present invention provides a urine calcium oxalate crystal detection device. Figure 1As shown, it includes: a collection structure 1 and a detection structure 2. The collection structure 1 is used to collect urine, and the collection structure 1 includes a first container 11 and a second container 12. The first container 11 has a urine retention port, which is convenient for the patient to retain urine in the first container 11. In order to facilitate the patient to take the first container 11, a handle 114 can be set on the side wall of the first container 11, and the handle 114 can be held to retain urine during use. The first container 11 has a first port 111, and the second container 12 has a second port 121 and a third port 122. The first port 111 and the second port 121 are detachably connected. The first port 111 is a first connecting tube, and the second port 121 is a second connecting tube. The first connecting tube can be threadedly connected with the second connecting tube to realize the detachable connection between the first port 111 and the second port 121. The first port 111 and the second port 121 are connected together. When the patient retains urine in the first container 11, the urine flows into the second container 12 along the first port 111 and the second port 121. The detection structure 2 is used to detect the collected urine. The detection structure 2 includes a third container 21, a fourth container 22 and a sealing assembly 23. The third container 21 has a fourth port 211. The fourth port 211 is detachably connected to the third port 122. The fourth port 211 is a fourth connecting tube. The third port 122 is a third connecting tube. The fourth connecting tube and the third connecting tube are threadedly connected to achieve detachable connection between the fourth port 211 and the third port 122. The third container 21 is filled with a reaction substance for reacting with urine to generate calcium oxalate crystals. The reaction substance is a fixed form of oxalic acid and calcium chloride. The fourth container 22 is arranged above the third container 21. The bottom end is open, the top end of the third container 21 is open, and a sealing component 23 is provided between the bottom end of the fourth container 22 and the top end of the third container 21. The fourth container 22 is filled with an indole solution for reacting with the calcium oxalate crystals in the third container 21. The indole solution is also an indole reagent. Indole is prepared by catalytic dehydrogenation of o-aminoethylbenzene. The indole reagent is prepared by dissolving 100 mg of indole in 100 ml of concentrated sulfuric acid. By setting the sealing component 23, the third container 21 does not react with the indole solution in the fourth container 22 before the reaction occurs, and the sealing component 23 can be opened to facilitate the indole solution in the fourth container 22 to react with the reacted substance in the third container 21. When the device is used, the patient's urine is first collected through the collection structure 1, and then directly detected through the detection structure 2 connected to the collection structure 1, which is convenient to use.Specifically, when collecting urine, the first port 111 and the second port 121 are connected together, and the patient holds the handle 114 on the first container 11 to retain urine. The urine flows into the second container 12 along the first port 111 and the second port 121 to complete the collection of urine. At this time, the first port 111 and the second port 121 can be disassembled, the first container 11 is removed, and then the collected urine is tested. Before the test, the second port 121 needs to be blocked and then the fourth port 211 and the third port 122 are connected together. If. Figure 1 In this state, the second container 12 can be inverted so that the urine in the second container 12 flows into the third container 21 through the third port 122 and the fourth port 211, so that the urine reacts with the reaction substance in the third container 21. After the third container 21 is allowed to stand at room temperature for about 15 minutes, the remaining liquid in the third container 21 is discharged. At this time, the calcium oxalate crystals in the urine remain in the third container 21. The sealing component 23 is opened to allow the indole solution in the fourth container 22 to enter the third container 21, so that it is fully mixed with the substance in the third container 21. The solution is allowed to stand at room temperature for about 2 hours, and the approximate concentration of the calcium oxalate crystals in the urine obtained in the third container 21 is compared with a colorimetric card. If the concentration range is obviously within the healthy range, there is no need to go to the hospital for re-examination. If the concentration range obtained is obviously within the abnormal range or within the ambiguous numerical range, the entire third container 21 can be removed and taken to a hospital or other testing platform for testing to obtain a more accurate concentration value, so as to determine whether there is an abnormality. This device can realize the convenient detection of calcium oxalate crystals in urine. The patient can detect the concentration of calcium oxalate crystals in urine in a community hospital or at home without going to the hospital, which is convenient for patients to monitor their own condition changes. It is suitable for early screening or postoperative monitoring of kidney stones. If you need to further obtain an accurate concentration value, you don’t need to go to the hospital to collect urine for re-testing. You can directly take the third container 21 for testing, saving the process of queuing up for examination in the hospital. It is fast and convenient and does not require patients to face the environment of the hospital toilet. Among them, the second container 12 is a disposable urine bag. The capacity of the second container 12 is about 200ml, ml is milliliter, and it is thrown away after one use, which is convenient and hygienic.

[0034] Furthermore, the fourth container 22 is a bag body, which is also a disposable bag body, which is thrown away after use, which is convenient and hygienic. This embodiment provides a specific structure of a sealing component 23, such as Figure 2 As shown, Figure 2 The upper and lower arcs in the figure are cutoff lines. The sealing assembly 23 includes: a plate 231, a first through hole 232, a film 233, and an airbag 234. The plate 231 is horizontally mounted in the third container 21, and the plate 231 is located at one end where the third container 21 and the fourth container 22 are connected. Figure 3As shown, a first through hole 232 is provided in the middle of the plate body 231, and the first through hole 232 vertically penetrates the plate body 231. The circumference of the film 233 is fixed to the side wall of the first through hole 232, and is used to block the first through hole 232. The film 233 is made of plastic material, and the position where the third container 21 and the fourth container 22 are connected can be sealed through the plate body 231 and the film 233. The airbag 234 is arranged above the film 233, and the airbag 234 is filled with air. The airbag 234 is connected to the film 233 through a first heat-sealing tape, and the airbag 234 is connected to the bottom of the fourth container 22 through a second heat-sealing tape. The first heat-sealing tape and the second heat-sealing tape are heat-sealing tape structures, which belong to a packaging process and can be opened under the action of external force, similar to the bag of the squeeze mask in life, and the packaging structure between the liquid and the membrane cloth. Before the reaction substance in the third container 21 reacts with urine, the sealing component 23 of the device is always in a sealed state, which can isolate the third container 21 from the fourth container 22. When the indole solution in the fourth container 22 needs to be guided into the third container 21, the airbag 234 is squeezed to increase the air pressure in the airbag 234, thereby breaking the first heat-sealing tape and the second heat-sealing tape, so that the indole solution in the fourth container 22 flows into the third container 21 through the airbag 234 and the film 233.

[0035] Furthermore, a second through hole 112 is formed at one end of the first container 11 away from the first port 111. The second through hole 112 is a urine retention port for the patient to retain urine. A baffle 113 is vertically provided on the second through hole 112. Figure 1 The baffle 113 shown is hemispherical and is provided to prevent urine from splashing when the patient retains urine.

[0036] When detecting calcium oxalate crystals in urine, the concentration of calcium oxalate crystals in "midstream urine" is closest to the concentration of calcium oxalate crystals in the patient's urine. Midstream urine refers to the middle part of urine left after removing the initial 20-200 ml of urine and the last urine during normal urination. However, during the current testing in the hospital, patients are required to retain urine on their own. Some patients may not be able to correctly operate to obtain "midstream urine", so that the measured results may deviate slightly from the actual results. In order to detect calcium oxalate crystals in "midstream urine" during testing, the present device further provides a partition 123 in the second container 12, and the partition 123 separates the first The second container 12 is divided into a first cavity 124 and a second cavity 125. The first cavity 124 is located above the second cavity 125. The capacity of the first cavity 124 is greater than that of the second cavity 125. The first cavity 124 and the second cavity 125 are upper and lower chambers respectively. The second port 121 and the third port 122 are located in the first cavity 124, that is, in the upper chamber. A one-way valve 126 is provided on the partition 123. The one-way valve is a fluid that can only flow along the water inlet, but the water outlet medium cannot flow back. The liquid in the first cavity 124 flows into the second cavity 125 through the one-way valve 126, while the liquid in the second cavity 125 cannot flow into the first cavity 124. When the patient retains urine, when the urine flows into the second container 12 through the first port 111 and the second port 121, the initial urine first flows into the second cavity 125 along the one-way valve 126. When the second cavity 125 is full, the second cavity 125 collects the initial urine, and the initial urine will not flow back into the first cavity 124. Subsequently, the patient's mid-stream urine is retained in the first cavity 124. Because the overall capacity of the second container 12 is set at about 200 ml, after the first cavity 124 is full, the latter urine will not be discharged into the first cavity 124, so that only the mid-stream urine exists in the first cavity 124. Because the setting of the one-way valve 126 will not mix with the initial urine, the one-way valve 126 isolates the initial urine and the mid-stream urine, so that the third container 21 detects the mid-stream urine in the first cavity 124 during detection, so that the measured result is closer to the accurate value.

[0037] Example 2 As a further improvement on Example 1, for more convenient use, further, the third container 21 is a cylinder, the third container 21 can adopt a syringe structure, and a suction structure 24 is provided in the third container 21, and the suction structure 24 is used to suck the liquid in the second container 12. In this embodiment, when in use, the second container 12 does not need to be inverted, and the urine in the second container 12 can be sucked into the third container 21 through the suction structure 24, and the provision of the suction structure 24 also avoids the problem of liquid backflow or liquid leakage when the second container 12 and the third container 21 are disassembled, which is more convenient for patients to perform detection operations.

[0038] This embodiment provides a specific structure of a suction structure 24. Further, the suction structure 24 includes: a piston 241 and an electric telescopic rod 242. The piston 241 is sleeved in the third container 21, and the piston 241 is slidably connected to the inner wall of the third container 21, and the piston 241 can slide up and down in the third container 21. The electric telescopic rod 242 is vertically arranged on the top of the piston 241, and the top of the electric telescopic rod 242 is fixed to the plate body 231. The electric telescopic rod 242 is used to drive the piston 241 to slide in the third container 21, and the electric telescopic rod 242 has the function of electric telescopic extension. When the suction structure 24 is in use, the piston 241 can be driven to slide in the third container 21 by controlling the extension of the electric telescopic rod 242, so as to facilitate the suction of urine in the second container 12 into the third container 21, and can also avoid urine reflux, and at the same time, the remaining liquid can be discharged from the third container 21 after the reaction is completed. In order to prevent the piston 241 from affecting the introduction of the indole solution in the fourth container 22 into the third container 21, a through hole is passed through the piston 241 in this embodiment, and a solenoid valve is provided on the through hole. When the urine in the second container 12 is sucked, the solenoid valve is closed. When the indole solution in the fourth container 22 needs to be introduced into the third container 21, the solenoid valve is opened, and the indole solution can react with the substance in the third container 21 through the through hole.

[0039] Based on the above scheme, in order to prevent the reaction material in the third container 21 from falling from the fourth port 211 or the suction structure 24 from squeezing out the calcium oxalate crystals when the remaining solution after the reaction is pushed out, further, a filter screen 212 is horizontally arranged in the third container 21, and the filter screen 212 is located below the piston 241. In this embodiment, a filter screen 212 is arranged in the third container 21, and the filter screen 212 is located near the fourth port 211, which can prevent the reaction material in the third container 21 from falling from the fourth port 211 or the suction structure 24 from squeezing out the calcium oxalate crystals when the remaining solution after the reaction is pushed out. Among them, the filter screen 212 is made of a filter membrane with a pore size of 0.22μm, and μm is micrometer, which is a unit of length.

[0040] Among them, other structures of this embodiment are consistent with those of embodiment 1, and are just optimizations made to embodiment 1.

[0041] Example 3 The embodiment of the present invention provides a method for using a urine calcium oxalate crystal detection device, which is based on a urine calcium oxalate crystal detection device in the above-mentioned embodiments 1 and 2, and includes the following steps: The first step: connecting the first port 111 of the first container 11 and the second port 121 of the second container 12 together, which can be threaded connection.

[0042] Step 2: urine is retained in the first container 11 through the second through hole 112, and urine flows into the second container 12 through the first port 111 and the second port 121 in sequence, and the initial urine flows into the second cavity 125. After the second cavity 125 is filled, the middle urine is retained in the first cavity 124, and then the first port 111 and the second port 121 are separated, and the first port 111 and the second port 121 are blocked with a rubber stopper, or other structures can be used to block the first port 111 and the second port 121.

[0043] Step 3: Connect the third port 122 of the second container 12 and the fourth port 211 of the third container 21 together, which can be threaded connection, and use the suction structure 24 to suck the urine in the second container 12 into the third container 21, that is, the middle urine in the first cavity 124 is sucked into the third container 21, and the urine reacts chemically with the reaction substance in the third container 21, and the urine reacts with the oxalic acid and calcium chloride in the third container 21 to obtain calcium oxalate crystals.

[0044] Step 4: Separate the third port 122 and the fourth port 211, plug the third port 122 and the fourth port 211 with a rubber plug, or use other structures to plug the third port 122 and the fourth port 211, let the third container 21 stand at room temperature for about 15 minutes, then open the rubber plug of the fourth port 211, and push the remaining liquid in the third container 21 out through the suction structure 24.

[0045] Step 5: Seal the fourth port 211, squeeze the airbag 234 to open the first heat-sealing tape and the second heat-sealing tape, and open the solenoid valve on the piston 241 at the same time, so that the indole solution in the fourth container 22 flows into the third container 21, and after being fully mixed, let it stand at room temperature for about 2 hours.

[0046] Step 6: Use a colorimetric card to compare the approximate concentration of calcium oxalate crystals in the urine obtained in the third container 21, because calcium oxalate reacts with the indole solution to produce a color change, and different colors correspond to different concentrations of calcium oxalate.

[0047] Further, the reaction substance includes 0.45mg of oxalic acid and 27.75mg of calcium chloride. mg is milligram, which is a unit of weight. The reason why 0.45mg of oxalic acid is first added in the third container 21 is that the calcium oxalate solution will react with the indole solution only after reaching a certain concentration, and the content of oxalic acid in urine may not reach this basic value. Therefore, it is necessary to add 0.45mg of oxalic acid so that the content of oxalic acid reaches the basic value of color change in subsequent reactions. The content of calcium chloride in this embodiment is sufficient, and these calcium chlorides still have enough surplus to react with the oxalic acid in urine after reacting with 0.45mg of oxalic acid. In practical applications, the content of calcium chloride can be appropriately increased or decreased as needed, and the degree of increase or decrease can be calculated according to the chemical reaction equation of oxalic acid and calcium chloride. Among them, the production principle of the above-mentioned colorimetric card also adopts the principle of the reaction of the above-mentioned calcium oxalate solution and indole solution. The calcium oxalate solution after the reaction of 0.45 mg of oxalic acid and an appropriate amount of calcium chloride is reacted with the indole solution and the color of the solution after the reaction is extracted. This is the lightest color in the colorimetric card. Then, the content of oxalic acid is gradually increased, that is, the concentration of the calcium oxalate solution is gradually increased, and then the above-mentioned reaction of the calcium oxalate solution and the indole solution is repeated to extract the color of the solution after the reaction, and a colorimetric card with changing concentration and color is produced. In practical applications, the colorimetric card can be commercialized, which is convenient for patients to observe changes in their own condition by comparing with the colorimetric card when testing at home.

[0048] The advantage of the present invention is that when the device is used, the patient's urine is first collected through the collection structure, and then the detection structure connected to the collection structure is directly used for detection, so that the result of the patient's condition change can be obtained, and the use is convenient. The device can realize the convenient detection of calcium oxalate crystals in urine. The patient can detect the concentration of calcium oxalate crystals in urine in a community hospital or at home without going to the hospital, which is convenient for the patient to monitor the changes in his or her condition. It is suitable for early screening or postoperative monitoring of kidney stones, and if it is necessary to further obtain an accurate concentration value, there is no need to go to the hospital to collect urine for re-testing. The third container can be directly taken for testing, which saves the process of queuing up for examination in the hospital, is fast and convenient, and does not require the patient to face the environment of the hospital toilet.

[0049] The above disclosures are only several specific embodiments of the present invention. However, the embodiments of the present invention are not limited thereto. Any changes that can be conceived by those skilled in the art should fall within the protection scope of the present invention.

Claims

1. A urine calcium oxalate crystal detection device, characterized in that: include: A collection structure (1) for collecting urine, the collection structure (1) comprising a first container (11) and a second container (12), the first container (11) having a first port (111), the second container (12) having a second port (121) and a third port (122), the first port (111) being detachably connected to the second port (121); A detection structure (2) for detecting collected urine, the detection structure (2) comprising a third container (21), a fourth container (22) and a sealing assembly (23), the third container (21) having a fourth port (211), the fourth port (211) being detachably connected to the third port (122), the third container (21) being filled with a reaction substance for reacting with urine to generate calcium oxalate crystals, the fourth container (22) being arranged above the third container (21), the bottom end of the fourth container (22) being open, the top end of the third container (21) being open, the sealing assembly (23) being arranged between the bottom end of the fourth container (22) and the top end of the third container (21), the fourth container (22) being filled with an indole solution for reacting with the calcium oxalate crystals in the third container (21).

2. A urine calcium oxalate crystal detection device according to claim 1, characterized in that: A partition (123) is provided in the second container (12), and the partition (123) divides the second container (12) into a first chamber (124) and a second chamber (125); the first chamber (124) is located above the second chamber (125); the second port (121) and the third port (122) are located in the first chamber (124); a one-way valve (126) is provided on the partition (123); liquid in the first chamber (124) flows into the second chamber (125) through the one-way valve (126).

3. A urine calcium oxalate crystal detection device according to claim 2, characterized in that: The fourth container (22) is a bag, and the sealing assembly (23) comprises: A plate body (231) is horizontally mounted in the third container (21), and a first through hole (232) is formed in the middle of the plate body (231); A film (233), which is fixed to the side wall of the first through hole (232) in its circumferential direction and is used to block the first through hole (232); An airbag (234) is arranged above the film (233), the airbag (234) is filled with air, the airbag (234) is connected to the film (233) via a first heat-sealing tape, and the airbag (234) is connected to the bottom end of the fourth container (22) via a second heat-sealing tape.

4. A urine calcium oxalate crystal detection device according to claim 3, characterized in that: The third container (21) is a cylinder, and a suction structure (24) is provided inside the third container (21), wherein the suction structure (24) is used to suck the liquid in the second container (12).

5. A urine calcium oxalate crystal detection device according to claim 4, characterized in that: The suction structure (24) comprises: A piston (241) is sleeved in the third container (21), and the piston (241) is slidably connected to the inner wall of the third container (21); An electric telescopic rod (242) is vertically arranged on the top of the piston (241); the top end of the electric telescopic rod (242) is fixed to the plate body (231); and the electric telescopic rod (242) is used to drive the piston (241) to slide in the third container (21).

6. A urine calcium oxalate crystal detection device according to claim 5, characterized in that: A filter screen (212) is horizontally arranged in the third container (21), and the filter screen (212) is located below the piston (241).

7. A urine calcium oxalate crystal detection device according to claim 6, characterized in that: A second through hole (112) is formed at one end of the first container (11) away from the first port (111), and a baffle (113) is vertically provided on the second through hole (112), wherein the baffle (113) is hemispherical.

8. The method for using the urine calcium oxalate crystal detection device according to claim 7, characterized in that: The following steps are involved: Connecting a first port (111) of the first container (11) and a second port (121) of the second container (12); The urine is retained in the first container (11) through the second through hole (112), and the urine flows into the second container (12) through the first port (111) and the second port (121) in sequence, and then the first port (111) and the second port (121) are separated, and the first port (111) and the second port (121) are blocked with a rubber stopper; The third port (122) of the second container (12) is connected to the fourth port (211) of the third container (21), and the urine in the second container (12) is sucked into the third container (21) by using the suction structure (24), so that the urine reacts chemically with the reaction substance in the third container (21); The third port (122) and the fourth port (211) are separated, the third port (122) and the fourth port (211) are blocked with rubber plugs, the third container (21) is allowed to stand at room temperature for 15 minutes, and then the rubber plug of the fourth port (211) is opened to push out the remaining liquid in the third container (21) through the suction structure (24); The fourth port (211) is sealed, and the air bag (234) is squeezed to open the first heat-sealing tape and the second heat-sealing tape, so that the indole solution in the fourth container (22) flows into the third container (21), and after being fully mixed, the solution is left to stand at room temperature for 2 hours; The approximate concentration of calcium oxalate crystals in the urine obtained in the third container (21) is compared using a colorimetric card.

9. The method for using the urine calcium oxalate crystal detection device according to claim 8, characterized in that: The reaction mass included 0.45 mg of oxalic acid and 27.75 mg of calcium chloride.

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