Hemodynamics simulation analysis system for coronary stent implantation

Abstract

The invention relates to the technical field of medical engineering, in particular to a hemodynamic simulation analysis system for coronary stent implantation. The system comprises a coronary blood vessel anatomical structure aided design module, a coronary stent finite element model design module, a post-implantation hemodynamic simulation analysis module and a pre-implantation and post-implantation blood flow state evaluation module, and can obtain coronary medical image data of a patient and perform blood vessel anatomical structure geometric analysis and blood vessel three-dimensional model aided design. Generating a three-dimensional model of the coronary vessel anatomical structure of the patient; a coronary stent finite element model is designed and generated through a geometric feature set of the coronary stent, a hemodynamic feature parameter set before stent implantation is obtained, blood flow boundary limitation analysis and coronary stent implantation dynamics simulation analysis are carried out, and meanwhile blood flow state evaluation analysis before and after stent implantation is carried out. And generating a blood flow state simulation evaluation report before and after stent implantation. According to the method, the change of the blood flow state after the stent is implanted can be efficiently and accurately analyzed.

Description

Technical Field

[0001] The present invention relates to the field of medical engineering technology, and in particular to a hemodynamic simulation analysis system for coronary stent implantation. Background Art

[0002] In recent years, hemodynamic simulation analysis methods have gradually attracted attention in the medical field. Through computational fluid dynamics (CFD) technology, researchers first reconstructed the patient's coronary artery three-dimensional geometric model by obtaining the patient's medical imaging data (such as CT or MRI), and simulated the blood flow inside and outside the stent under different stent implantation schemes by applying high-precision CFD technology. The blood flow characteristics after stent implantation, including flow velocity, pressure distribution and turbulence characteristics, were analyzed. This method can perform virtual tests of various stent designs before and after implantation, thereby providing a basis for selecting the optimal stent. However, existing simulation analysis methods often rely on simplified models or fixed physiological parameters, lack simulation evaluation of blood flow velocity, pressure distribution and turbulent dynamic characteristics, and cannot fully reflect the impact of coronary stents on blood flow status. Summary of the invention

[0003] Based on this, it is necessary for the present invention to provide a hemodynamic simulation analysis system for coronary stent implantation to solve at least one of the above technical problems.

[0004] To achieve the above purpose, a hemodynamic simulation analysis system for coronary stent implantation includes the following modules: The coronary vascular anatomical structure auxiliary design module is used to obtain the patient's coronary medical imaging data, and perform vascular anatomical structure geometric analysis on the patient's coronary medical imaging data to obtain the patient's coronary vascular anatomical structure geometric feature set; perform vascular three-dimensional model auxiliary design based on the patient's coronary vascular anatomical structure geometric feature set to generate a three-dimensional model of the patient's coronary vascular anatomical structure; A coronary stent finite element model design module is used to obtain a coronary stent geometric feature set and coronary stent material properties, and perform a stent finite element model design on the corresponding coronary stent based on the coronary stent geometric feature set and coronary stent material properties to generate a coronary stent finite element model; The post-implantation hemodynamic simulation analysis module is used to obtain the hemodynamic characteristic parameter set before stent implantation, and perform blood flow boundary restriction analysis on the hemodynamic characteristic parameter set before stent implantation to generate the patient's coronary blood flow boundary conditions; based on the patient's coronary blood flow boundary conditions, the patient's coronary vascular anatomical structure three-dimensional model and the coronary stent finite element model are subjected to coronary stent implantation dynamics simulation analysis to obtain the hemodynamic simulation distribution field after stent implantation; The blood flow status evaluation module before and after implantation is used to evaluate and analyze the blood flow status before and after stent implantation based on the hemodynamic characteristic parameter set before stent implantation and the hemodynamic simulation distribution field after stent implantation to generate a blood flow status simulation evaluation report before and after stent implantation.

[0005] Furthermore, the coronary vascular anatomical structure auxiliary design module includes the following functions: Obtain the patient's coronary medical imaging data; Performing image denoising on the patient's coronary medical image data to obtain coronary medical image denoising data; Performing image contrast enhancement processing on the denoised coronary medical image data to obtain coronary medical image contrast enhanced data; Performing vascular anatomical structure geometric analysis on coronary medical image contrast enhancement data to obtain a set of geometric feature sets of the patient's coronary vascular anatomical structure; A three-dimensional vascular model is assisted in designing the vascular model according to the geometric feature set of the patient's coronary vascular anatomical structure to generate a three-dimensional model of the patient's coronary vascular anatomical structure.

[0006] Furthermore, the vascular anatomical structure geometric analysis of the coronary medical image contrast enhancement data includes: Perform vascular anatomical structure calibration and recognition analysis on the coronary medical image contrast enhancement data to obtain the vascular anatomical structure of the coronary medical image; Based on the vascular anatomical structure of the coronary medical image, the vascular contour edge detection is performed on the corresponding patient's coronary medical image in the coronary medical image contrast enhancement data to obtain the contour boundary of the patient's coronary vascular anatomical structure; The structural geometric features of the vascular anatomical structure of the coronary medical image are calculated based on the contour boundary of the patient's coronary vascular anatomical structure to obtain a geometric feature set of the patient's coronary vascular anatomical structure.

[0007] Furthermore, the calculation of the structural geometric features of the vascular anatomical structure of the coronary medical image based on the contour boundary of the patient's coronary vascular anatomical structure includes: According to the vascular anatomical structure of coronary medical images, the vascular surface is interpolated and reconstructed to obtain the three-dimensional geometric structure diagram of the coronary vascular anatomy; Based on the contour boundary of the patient's coronary vascular anatomical structure, the length of each segment of the coronary vascular anatomical three-dimensional geometric structure diagram is measured to obtain the coronary vascular length corresponding to each segment of the coronary vascular; The vascular measurement cross-sections between the segments in the coronary vascular anatomical structure are set according to the coronary vascular lengths corresponding to the segments of the coronary vascular, and the dynamic diameter measurement is performed on the coronary vascular anatomical three-dimensional geometric structure diagram based on the vascular measurement cross-sections between the segments to obtain the coronary vascular diameters corresponding to the segments of the coronary vascular; the tangent curvature of each vascular segment in the coronary vascular anatomical three-dimensional geometric structure diagram is calculated according to the coronary vascular diameters corresponding to the segments of the coronary vascular, to obtain the coronary vascular tangent curvature corresponding to the segments of the coronary vascular; Based on the coronary vessel lengths corresponding to each segment of the coronary artery, the bifurcation angles between each segment of the coronary artery in the three-dimensional geometric structure diagram of the coronary artery anatomy are measured to obtain the coronary artery bifurcation angles corresponding to each segment of the coronary artery; The coronary anatomical structure geometric features of the coronary vessel length, coronary vessel diameter, coronary vessel tangent curvature and coronary vessel bifurcation angle are merged to obtain the patient's coronary anatomical structure geometric feature set.

[0008] Furthermore, the bifurcation angle measurement between each blood vessel segment in the three-dimensional geometric structure diagram of the coronary blood vessel anatomy based on the coronary blood vessel length corresponding to each coronary blood vessel segment includes: Identify and locate the bifurcation points between each vascular segment in the three-dimensional geometric structure diagram of the coronary vascular anatomy, and obtain the coronary vascular bifurcation points between each vascular segment in the coronary vascular anatomy; Based on the coronary bifurcation points between each vascular segment in the coronary vascular anatomical structure, a vascular direction vector description analysis is performed on each vascular segment in the coronary vascular anatomical three-dimensional geometric structure diagram to obtain the coronary vascular direction description vector corresponding to each coronary vascular segment; Based on the coronary artery length corresponding to each segment of the coronary artery, a vascular length vector description analysis is performed between the vascular bifurcation point and the end of the adjacent vascular segment in the coronary vascular anatomical three-dimensional geometric structure diagram, and the coronary artery length description vector corresponding to each segment of the coronary artery is obtained; Based on the coronary artery direction description vector and the coronary artery length description vector corresponding to each segment of the coronary artery, the bifurcation angle geometry calculation is performed between each segment of the coronary artery in the three-dimensional geometric structure diagram of the coronary artery anatomy to obtain the coronary artery bifurcation angle corresponding to each segment of the coronary artery.

[0009] Furthermore, the coronary stent finite element model design module includes the following functions: Obtaining a coronary stent geometric feature set and coronary stent material properties; Based on the coronary stent geometric feature set, the finite element geometric boundary of the corresponding coronary stent is set to generate the finite element geometric boundary conditions of the coronary stent; According to the finite element geometric boundary conditions of the coronary stent, a finite element model design framework of the corresponding coronary stent is constructed to obtain a finite element model design framework of the coronary stent; According to the material characteristics of the coronary stent, the pore and surface roughness constraint analysis of the corresponding coronary stent is performed to obtain the pore and surface roughness constraint conditions of the coronary stent; Based on the constraints of coronary stent porosity and surface roughness, the coronary stent finite element model design framework is refined to generate a coronary stent finite element model.

[0010] Furthermore, the post-implantation hemodynamic simulation analysis module includes the following functions: Acquire a hemodynamic characteristic parameter set before stent implantation, wherein the hemodynamic characteristic parameter set before stent implantation includes blood flow velocity distribution before stent implantation, blood flow pressure distribution before stent implantation, eddy current intensity distribution before stent implantation, and shear stress distribution before stent implantation; Performing blood flow boundary restriction analysis on the hemodynamic characteristic parameter set before stent implantation to generate the patient's coronary blood flow boundary conditions; Based on the patient's coronary blood flow boundary conditions, the patient's coronary vascular anatomical structure three-dimensional model is analyzed for blood flow dynamic changes, and a coronary vascular anatomical structure blood flow dynamic model is obtained; Based on the finite element model of coronary stent, the blood flow dynamic model of the coronary vascular anatomical structure is analyzed to analyze the blood flow dynamic response during stent implantation, and the blood flow dynamic response distribution field during stent implantation is obtained; Based on the hemodynamic response distribution field of the stent implantation process, the coronary hemodynamic simulation analysis of the coronary stent implantation process corresponding to the blood flow dynamic model of the coronary vascular anatomical structure and the coronary stent finite element model was performed to obtain the hemodynamic simulation distribution field after stent implantation.

[0011] Furthermore, the blood flow boundary restriction analysis of the hemodynamic characteristic parameter set before stent implantation includes: According to the blood flow velocity distribution before stent implantation in the hemodynamic characteristic parameter set before stent implantation, the blood flow velocity boundary constraint analysis is performed to obtain the blood flow inlet velocity boundary constraint condition before stent implantation; Based on the blood flow pressure distribution before stent implantation in the hemodynamic characteristic parameter set before stent implantation, the shear stress distribution before stent implantation is analyzed by the boundary constraint of the blood vessel wall flow force, and the boundary constraint condition of the blood vessel inner wall flow stress before stent implantation is obtained; According to the eddy current intensity distribution before stent implantation in the hemodynamic characteristic parameter set before stent implantation, a blood eddy current distribution boundary constraint analysis is performed to obtain the blood eddy current distribution boundary constraint conditions before stent implantation; The boundary conditions of blood flow inlet velocity before stent implantation, blood vessel inner wall flow stress before stent implantation and blood eddy flow distribution before stent implantation are merged to generate the patient's coronary blood flow boundary conditions.

[0012] Furthermore, the blood flow status assessment module before and after implantation includes the following functions: Performing a post-stent implantation dynamics characteristic analysis on the post-stent implantation hemodynamics simulation distribution field to obtain a post-stent implantation hemodynamics characteristic parameter set, wherein the post-stent implantation hemodynamics characteristic parameter set includes a post-stent implantation blood flow velocity distribution, a post-stent implantation blood flow pressure distribution, a post-stent implantation eddy current intensity distribution, and a post-stent implantation shear stress distribution; Based on the hemodynamic characteristic parameter set before stent implantation, a hemodynamic evaluation calculation formula before and after stent implantation is used to perform blood flow evaluation calculation on the hemodynamic characteristic parameter set after stent implantation to obtain the hemodynamic state evaluation value before and after stent implantation; The blood flow status before and after stent implantation is evaluated and analyzed based on the hemodynamic status evaluation values ​​before and after stent implantation to generate a blood flow status simulation evaluation report before and after stent implantation.

[0013] Furthermore, the hemodynamic evaluation calculation formula before and after stent implantation is specifically as follows: ; In the formula, It is the hemodynamic status assessment value before and after stent implantation. The starting time point for blood flow assessment calculation, The end time point calculated for blood flow assessment, is the time variable parameter, is the time difference between before and after stent implantation, For in time Blood flow velocity distribution after stent implantation at For in time Blood flow velocity distribution before stent implantation at For in time Blood flow pressure distribution after stent implantation, For in time Blood flow pressure distribution before stent implantation at For in time The eddy current intensity distribution after stent implantation at For in time The eddy current intensity distribution before stent implantation at For in time Shear stress distribution after stent implantation, For in time Shear stress distribution before stent implantation.

[0014] Beneficial effects of the present invention: The hemodynamic simulation and analysis system for coronary stent implantation proposed in the present invention is generally composed of a coronary vascular anatomical structure auxiliary design module, a coronary stent finite element model design module, a post-implantation hemodynamic simulation and analysis module, and a blood flow status evaluation module before and after implantation. Compared with the prior art, the beneficial effect of the present application lies in that by acquiring the patient's coronary medical imaging data and using high-resolution imaging technology (such as coronary angiography, CT coronary imaging or MRI), medical personnel can clearly observe the anatomical structure of the patient's coronary artery. These imaging data provide the necessary basic information for subsequent analysis and processing. Accurate image data acquisition can also improve the effectiveness of processing and analysis in subsequent steps, reduce errors and deviations, and thus provide a reliable basis for clinical decision-making. Through the geometric analysis of the vascular anatomical structure of the patient's coronary medical imaging data, the geometric analysis is to extract the anatomical characteristics and geometric parameters of the coronary artery through in-depth analysis of the enhanced image data. This process not only involves the basic geometric characteristics of the blood vessels such as length, diameter and branch angle, but also can further analyze the curvature of the blood vessels, hemodynamic characteristics and their relationship with the surrounding tissues, which can help to more comprehensively understand the patient's coronary artery status, thereby providing a scientific basis for the subsequent vascular 3D modeling process. At the same time, by performing auxiliary design of the vascular 3D model based on the geometric feature set of the patient's coronary vascular anatomical structure, based on the geometric features extracted in the previous step, a patient-specific 3D coronary model is generated through computer modeling technology. This model can not only truly reflect the patient's coronary anatomical structure, but also can be used to simulate blood flow dynamics and evaluate the effectiveness and safety of hemodynamic simulation after stent implantation. Secondly, by obtaining the geometric feature set of the coronary stent and its material properties, the geometric features usually include the diameter, length, shape, porosity, etc. of the stent, while the material properties involve the mechanical properties of the material used for the stent, such as elastic modulus, yield strength, fatigue limit and corrosiveness, etc. Accurately obtaining these data can not only ensure the authenticity of the finite element model construction, but also help predict the performance of the stent in the physiological environment. For example, by analyzing the impact of different geometric features on fluid dynamics, researchers can optimize the design of the stent to ensure its adaptability and effectiveness in the coronary artery.The corresponding coronary stent is also designed based on the coronary stent geometric feature set and the coronary stent material properties. This step can simulate and analyze its mechanical properties in practical applications by accurately modeling the stent geometry and corresponding characteristics. The finite element model provides a systematic method to describe and analyze complex structural characteristics, including local and overall stress distribution, deformation and fatigue behavior. The construction of the model must take into account the material properties and geometric complexity of the stent to ensure that the model truly reflects the physiological environment, and through further refinement, it can capture more complex physical phenomena, such as local stress concentration, material fatigue, etc. This refined design not only improves the accuracy of the stent finite element model, but also better reflects the interaction between the stent and the physiological environment in practical applications. Specifically, the refined design allows different material properties and geometric shapes to be accurately reflected in the model, making the simulation results more realistic. The refined model also provides reliable data support for the subsequent hemodynamic simulation and analysis process. Then, by obtaining the hemodynamic characteristic parameter set before stent implantation, the blood flow velocity distribution, blood flow pressure distribution, eddy intensity distribution and shear stress distribution can be analyzed in detail, and the dynamic characteristics of coronary blood flow can be fully understood. The blood flow velocity distribution can reflect the flow state of blood in the blood vessels and provide important information to identify possible blockages or eddy areas; the blood flow pressure distribution reveals the pressure changes at different locations in the blood vessels, which can help determine whether the blood vessels are at risk of stenosis or blockage; the eddy intensity distribution is a key factor in assessing the degree of blood flow disorder and can indicate areas of uneven blood flow; and the shear stress distribution is closely related to the physiological response of vascular endothelial cells and is an important indicator for judging vascular health. By integrating these hemodynamic characteristic parameters, a solid foundation can be laid for subsequent stent implantation and dynamic change analysis, ensuring the accuracy and effectiveness of subsequent steps, so as to better realize the simulation evaluation of dynamic characteristics such as blood flow velocity, pressure distribution and turbulence. By performing blood flow boundary restriction analysis on the hemodynamic characteristic parameter set before stent implantation, this process involves combining the obtained blood flow characteristics with the individual physiological structure of the patient to generate more accurate coronary blood flow boundary conditions. The definition of boundary conditions has an important impact on the accuracy of the calculation model and the effectiveness of the simulation results. Through the boundary restriction analysis of blood flow, the flow state of blood in the coronary artery can be better simulated, ensuring that the calculation results reflect the real physiological situation, providing key input for subsequent dynamic change analysis, and enhancing the credibility and applicability of the simulation analysis process.The dynamic simulation analysis of coronary stent implantation is also carried out on the three-dimensional model of the patient's coronary vascular anatomical structure and the finite element model of the coronary stent based on the patient's coronary blood flow boundary conditions. The core of this step is to simulate and analyze the changes in blood flow after stent implantation and its impact on vascular health. By establishing a detailed simulation model, the distribution of blood flow after implantation can be predicted, including key parameters such as blood flow velocity, pressure, eddy current intensity, and shear stress. This analysis can not only reveal the short-term and long-term effects after stent implantation, but also help doctors judge the adaptability of the stent and its impact on patients, so as to more accurately reflect the impact of coronary stent implantation on blood flow status. Finally, the blood flow status before and after stent implantation is evaluated and analyzed by the hemodynamic simulation distribution field after stent implantation based on the hemodynamic characteristic parameter set before stent implantation, so as to generate a simulation evaluation report of the blood flow status before and after stent implantation, which can provide systematic analysis results and data support for clinicians. These data can provide references for doctors in stent selection and postoperative management, and help formulate personalized plans. In addition, the detailed hemodynamic characteristics analysis in the report can help doctors better understand the postoperative blood flow status, identify possible complications early, and provide a scientific basis for subsequent decision support, thereby achieving a more comprehensive understanding of the impact of hemodynamic status after stent implantation. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Other features, objects and advantages of the present invention will become more apparent from the detailed description of non-limiting embodiments thereof made with reference to the following drawings: Figure 1 A schematic diagram of a module of a hemodynamic simulation analysis system for coronary stent implantation according to the present invention; Figure 2 for Figure 1 Schematic diagram of the functional flow of the coronary vascular anatomical structure auxiliary design module; Figure 3 for Figure 1 Schematic diagram of the functional flow of the coronary stent finite element model design module. DETAILED DESCRIPTION

[0016] The technical system of the present invention is described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by technicians in this field without creative work are within the scope of protection of the present invention.

[0017] In addition, the accompanying drawings are only schematic illustrations of the present invention and are not necessarily drawn to scale. The same reference numerals in the figures represent the same or similar parts, and their repeated description will be omitted. Some of the block diagrams shown in the accompanying drawings are functional entities and do not necessarily correspond to physically or logically independent entities. The functional entities can be implemented in software form, or implemented in one or more hardware modules or integrated circuits, or implemented in different networks and / or processor systems and / or microcontroller systems.

[0018] It should be understood that, although the terms "first", "second", etc. may be used herein to describe various units, these units should not be limited by these terms. These terms are used only to distinguish one unit from another unit. For example, without departing from the scope of the exemplary embodiments, the first unit may be referred to as the second unit, and similarly the second unit may be referred to as the first unit. The term "and / or" used herein includes any and all combinations of one or more of the listed associated items.

[0019] To achieve this, please refer to Figures 1 to 3 The present invention provides a hemodynamic simulation analysis system for coronary stent implantation, the system comprising the following modules: The coronary vascular anatomical structure auxiliary design module is used to obtain the patient's coronary medical imaging data, and perform vascular anatomical structure geometric analysis on the patient's coronary medical imaging data to obtain the patient's coronary vascular anatomical structure geometric feature set; perform vascular three-dimensional model auxiliary design based on the patient's coronary vascular anatomical structure geometric feature set to generate a three-dimensional model of the patient's coronary vascular anatomical structure; A coronary stent finite element model design module is used to obtain a coronary stent geometric feature set and coronary stent material properties, and perform a stent finite element model design on the corresponding coronary stent based on the coronary stent geometric feature set and coronary stent material properties to generate a coronary stent finite element model; The post-implantation hemodynamic simulation analysis module is used to obtain the hemodynamic characteristic parameter set before stent implantation, and perform blood flow boundary restriction analysis on the hemodynamic characteristic parameter set before stent implantation to generate the patient's coronary blood flow boundary conditions; based on the patient's coronary blood flow boundary conditions, the patient's coronary vascular anatomical structure three-dimensional model and the coronary stent finite element model are subjected to coronary stent implantation dynamics simulation analysis to obtain the hemodynamic simulation distribution field after stent implantation; The blood flow status evaluation module before and after implantation is used to evaluate and analyze the blood flow status before and after stent implantation based on the hemodynamic characteristic parameter set before stent implantation and the hemodynamic simulation distribution field after stent implantation to generate a blood flow status simulation evaluation report before and after stent implantation.

[0020] In the embodiment of the present invention, please refer to Figure 1 FIG. 1 is a schematic diagram of a hemodynamic simulation analysis system for coronary stent implantation according to the present invention. In this example, the hemodynamic simulation analysis system for coronary stent implantation includes the following modules: S1: A coronary vascular anatomical structure auxiliary design module, which is used to obtain the patient's coronary medical imaging data, and perform vascular anatomical structure geometric analysis on the patient's coronary medical imaging data to obtain the patient's coronary vascular anatomical structure geometric feature set; perform vascular three-dimensional model auxiliary design based on the patient's coronary vascular anatomical structure geometric feature set to generate a three-dimensional model of the patient's coronary vascular anatomical structure; In an embodiment of the present invention, high-quality images are acquired by scanning with medical imaging equipment. Common imaging equipment includes multi-row spiral CT or magnetic resonance imaging (MRI) equipment. These equipment enhance the imaging effect of blood vessels by applying specific scanning protocols and combining the use of contrast agents. After the image acquisition is completed, the data is imported from the imaging equipment into the medical imaging processing system to ensure that the data format meets the subsequent processing requirements, thereby obtaining the patient's coronary medical imaging data. The image quality is improved and artifacts are reduced by performing image denoising on the acquired coronary medical image data of the patient. This process can utilize denoising techniques such as median filtering, Wiener filtering or wavelet transform. By selecting a suitable filter, the image data is processed to remove high-frequency noise and retain the main features of the image. The image contrast is enhanced by using histogram equalization technology or adaptive histogram equalization (CLAHE). The histogram features of the image are analyzed, and the image brightness and contrast parameters are adjusted to make the contrast between the blood vessels and the surrounding tissues more obvious. After contrast enhancement processing, the edges of the vascular structures in the image are clearer and the details are richer. At the same time, the geometric analysis of the vascular anatomical structure is performed to extract the geometric feature set of the patient's coronary vascular anatomical structure. This step first uses image segmentation technology, and uses a threshold method, a region growing method or a machine learning algorithm to effectively separate the blood vessels. Subsequently, by analyzing the extracted vascular contours, its geometric features, including the diameter, length, curvature and bifurcation angle of the blood vessels, are calculated to generate a detailed geometric feature set, thereby obtaining the geometric feature set of the patient's coronary vascular anatomical structure. Then, the 3D model of the blood vessels is assisted in design based on the set of geometric features of the patient's coronary vascular anatomical structure obtained from the previous statistical analysis. This step uses computer-aided design (CAD) software to input the geometric feature data obtained in the previous step into the system for 3D modeling. The 3D model is generated using modeling tools based on the shape, size, and position of the blood vessels. The model may include various branches of the coronary arteries and their characteristics. After the 3D model is completed, it is visualized through the software and combined with finite element analysis tools to evaluate the hemodynamic characteristics, ultimately generating a 3D model of the patient's coronary vascular anatomical structure.

[0021] S2: A coronary stent finite element model design module, which is used to obtain a coronary stent geometric feature set and coronary stent material properties, and to perform a stent finite element model design on the corresponding coronary stent based on the coronary stent geometric feature set and coronary stent material properties, so as to generate a coronary stent finite element model; In an embodiment of the present invention, by collecting the geometric feature set of the coronary stent, including the diameter, length, support structure, aperture and the angular relationship between the stent, etc., the stent can be three-dimensionally modeled using computer-aided design (CAD) software (such as SolidWorks or AutoCAD) to generate accurate geometric feature data. In addition, according to the characteristics of the selected material, the physical and mechanical parameters of the material need to be obtained, including elastic modulus, yield strength, tensile strength and Poisson's ratio, etc. These data can be obtained through laboratory testing, or by referring to standard values ​​in existing literature, so as to obtain the coronary stent geometric feature set and the coronary stent material characteristics. By combining the previously obtained coronary stent geometric feature set with finite element analysis software (such as ANSYS or COMSOL Multiphysics) is used to set the geometric boundaries of the corresponding coronary stent. First, the three-dimensional model of the stent generated in the CAD software is imported, and the geometric boundary conditions of the stent are defined in the software, including the contact surface of the fixed stent and its contact interface with the surrounding tissue or blood vessel wall, and the corresponding constraints and loading conditions are set to form stable finite element geometric boundary conditions. After completing the geometric boundary setting, it is necessary to build a finite element model design framework for the coronary stent based on these boundary conditions, select a suitable meshing strategy, and mesh the stent according to the complexity of the model and the required analysis accuracy. High-quality hexahedral meshes or tetrahedral meshes can be used for meshing in order to capture the details of the stent structure, and combine the material properties with the geometric boundary conditions just set to form a complete finite element model design framework. At the same time, the pore and surface roughness constraint analysis of the corresponding coronary stent is carried out according to the material properties of the coronary stent, so as to use the finite element analysis software First, the porosity parameter is introduced into the stent model to simulate the influence of the tiny pores that may exist in the actual material on the mechanical properties. At the same time, the characteristics of the surface roughness are defined. By setting the roughness model (such as using Ra or Rz values), a certain roughness constraint is imposed on the contact surface between the stent and the inner wall of the blood vessel. Then, the finite element model design framework is refined by combining the constraints of pores and surface roughness obtained by combining the previous constraint analysis. In this process, the grid division is further optimized in combination with the constraints obtained in the previous steps to ensure that the grid density in the pore and roughness feature areas is high to improve the accuracy and stability of the calculation. At the same time, the parameter settings of the material model are adjusted to reflect the nonlinear and anisotropic characteristics of the material in actual applications. The solver is used for simulation calculations to analyze the hemodynamic characteristics, including flow velocity, pressure distribution, and shear stress, to evaluate the functional performance of the coronary stent after implantation and its impact on the surrounding blood flow, and finally a complete coronary stent finite element model is refined and generated.

[0022] S3: Post-implantation hemodynamic simulation analysis module, used to obtain the hemodynamic characteristic parameter set before stent implantation, and perform blood flow boundary restriction analysis on the hemodynamic characteristic parameter set before stent implantation to generate the patient's coronary blood flow boundary conditions; based on the patient's coronary blood flow boundary conditions, perform coronary stent implantation dynamics simulation analysis on the patient's coronary vascular anatomical structure three-dimensional model and the coronary stent finite element model to obtain the hemodynamic simulation distribution field after stent implantation; In an embodiment of the present invention, by adopting high-resolution medical imaging technology, such as CT angiography (CTA) or magnetic resonance imaging (MRI), the patient's coronary blood vessels are imaged to obtain accurate geometric structure data, and by using computational fluid dynamics (CFD) software for simulation, boundary conditions are set and blood is regarded as an incompressible non-Newtonian fluid, and blood flow velocity, pressure, vortex intensity and shear stress are calculated by numerical methods (such as finite element method or finite volume method), and fluid dynamics equations (such as Navier-Stokes equations) are solved to obtain blood flow velocity distribution, pressure distribution, vortex intensity distribution and shear stress distribution before stent implantation, thereby obtaining a set of hemodynamic characteristic parameters before stent implantation, including blood flow velocity distribution before stent implantation, blood flow pressure distribution before stent implantation, vortex intensity distribution before stent implantation and shear stress distribution before stent implantation. By performing boundary condition analysis based on the hemodynamic characteristic parameter set before stent implantation obtained from previous analysis, the flow boundary restriction analysis tool is used to define the no-slip condition of the blood vessel wall, the inlet flow condition and the outlet pressure condition to generate accurate blood flow boundary conditions, that is, the maximum and minimum values ​​corresponding to the inlet velocity, flow stress and eddy distribution. The flow boundary conditions obtained from previous analysis are applied to the CFD software to perform dynamic flow analysis on the previously constructed three-dimensional model of the patient's coronary vascular anatomical structure. The previously generated blood flow boundary conditions are input, and the model is divided into small units using meshing technology to ensure the accuracy of fluid calculations. In the flow dynamic analysis, the flow of blood in the coronary artery is simulated by setting the time step, and the changes in the flow process, including the time series changes of the velocity field and the pressure field, are recorded. At the same time, by combining the previously constructed coronary stent The finite element model is coupled with the dynamic model of blood flow in the anatomical structure of the coronary artery to analyze the stent implantation in order to set the initial position and angle of the stent implantation. The dynamic response of the blood flow during the stent implantation process is analyzed by applying dynamic loads, and the force of the blood flow on the stent and the influence of the stent on the blood flow are simulated. Then, the hemodynamic response distribution field obtained by the previous response analysis is combined with the dynamic model of the blood flow in the anatomical structure of the coronary artery and the coronary stent implantation simulation process corresponding to the finite element model of the coronary stent to perform a simulation analysis of the hemodynamics after the stent implantation. The CFD software is used to further calculate the blood flow field after implantation, analyze the influence of the stent on the blood flow velocity, pressure and shear stress, and obtain the hemodynamic distribution of each part after the stent implantation by setting specific calculation areas and simulation parameters. Finally, the hemodynamic simulation distribution field after the stent implantation is obtained by simulation.

[0023] S4: A blood flow status evaluation module before and after implantation, which is used to evaluate and analyze the blood flow status before and after stent implantation based on the hemodynamic characteristic parameter set before stent implantation and the hemodynamic simulation distribution field after stent implantation, so as to generate a blood flow status simulation evaluation report before and after stent implantation.

[0024] In an embodiment of the present invention, by using computational fluid dynamics (CFD) software, such as ANSYS Fluent or COMSOL Multiphysics, a statistical analysis of the hemodynamic characteristics of the hemodynamic simulation distribution field after stent implantation generated by the previous simulation is performed to implant the stent model accordingly, adjust the contact relationship between the geometric parameters of the stent and the blood vessel wall, and set boundary conditions, including blood inflow velocity and pressure, etc., to perform numerical simulation calculations to obtain parameters such as blood flow velocity distribution, pressure distribution, eddy current intensity distribution, and shear stress distribution after stent implantation. By combining time parameters, blood flow velocity distribution after stent implantation, blood flow velocity distribution before stent implantation, blood flow pressure distribution after stent implantation, blood flow pressure distribution before stent implantation, eddy current intensity distribution after stent implantation, eddy current intensity distribution before stent implantation, shear stress distribution after stent implantation, shear stress distribution before stent implantation, and related parameters, a suitable dynamic evaluation calculation formula is formed to perform blood flow evaluation calculation on the hemodynamic characteristic parameter set after stent implantation. This step The core of this step is to compare the changes in parameters before and after, calculate the corresponding evaluation values, and conduct a detailed blood flow status evaluation and analysis after obtaining the dynamic state evaluation values. This process requires a systematic comparison and analysis of the evaluation values ​​to extract key features, such as the percentage of change in blood flow velocity, the range of pressure changes, the increase or decrease in eddy current intensity, and the effect of shear stress on the inner wall of the blood vessel. By drawing comparison charts or data tables, the change trends before and after implantation are clearly presented, and professional chart software (such as Origin or Excel) is used for data visualization. At the same time, combined with clinical standards and data, a systematic simulation evaluation report is formed to describe in detail the impact of stent implantation on blood flow status, possible clinical significance and follow-up observation suggestions. The generated report provides a basis for clinical decision-making, ensuring that the blood flow status after stent implantation is effectively evaluated and monitored, and finally the corresponding blood flow status simulation evaluation report before and after stent implantation is generated.

[0025] Furthermore, the coronary vascular anatomical structure auxiliary design module includes the following functions: Obtain the patient's coronary medical imaging data; Performing image denoising on the patient's coronary medical image data to obtain coronary medical image denoising data; Performing image contrast enhancement processing on the denoised coronary medical image data to obtain coronary medical image contrast enhanced data; Performing vascular anatomical structure geometric analysis on coronary medical image contrast enhancement data to obtain a set of geometric feature sets of the patient's coronary vascular anatomical structure; A three-dimensional vascular model is assisted in designing the vascular model according to the geometric feature set of the patient's coronary vascular anatomical structure to generate a three-dimensional model of the patient's coronary vascular anatomical structure.

[0026] As an embodiment of the present invention, refer to Figure 2 As shown, Figure 1 The function flow diagram of the coronary vascular anatomical structure auxiliary design module is shown in FIG. 1 . In this embodiment, the functions of the coronary vascular anatomical structure auxiliary design module include: S11: Obtain the patient's coronary medical imaging data; In an embodiment of the present invention, high-quality images are acquired by scanning with medical imaging equipment. Common imaging equipment includes multi-row spiral CT or magnetic resonance imaging (MRI) equipment. These equipment enhance the imaging effect of blood vessels by applying specific scanning protocols and combining the use of contrast agents. After the image acquisition is completed, the data is imported from the imaging equipment into the medical imaging processing system to ensure that the data format meets the requirements of subsequent processing. The DICOM (Digital Imaging and Communications in Medicine) format is usually used to ensure the integrity and compatibility of the data, and finally the patient's coronary medical imaging data is obtained.

[0027] S12: performing image denoising processing on the patient's coronary medical image data to obtain coronary medical image denoising data; In an embodiment of the present invention, image denoising is performed on the acquired coronary medical image data of the patient to improve image quality and reduce artifacts. This process can utilize denoising techniques such as median filtering, Wiener filtering or wavelet transform. By selecting a suitable filter, the image data is processed to remove high-frequency noise and retain the main features of the image. During the implementation process, the parameters of the filter are set to ensure the best denoising effect, maintain the clarity and integrity of the vascular structure, and finally obtain coronary medical image denoising data.

[0028] S13: performing image contrast enhancement processing on the coronary medical image denoising data to obtain coronary medical image contrast enhanced data; In an embodiment of the present invention, image contrast enhancement processing is performed on coronary medical image denoising data in order to improve the visibility and recognition of blood vessels. This processing step can be implemented through histogram equalization technology or adaptive histogram equalization (CLAHE), analyzing the histogram characteristics of the image, adjusting the image brightness and contrast parameters to make the contrast between the blood vessels and surrounding tissues more obvious. After contrast enhancement processing, the edges of the vascular structure in the image are clearer and the details are richer, and finally coronary medical image contrast enhanced data is obtained.

[0029] S14: performing vascular anatomical structure geometric analysis on the coronary medical image contrast enhancement data to obtain a set of geometric features of the patient's coronary vascular anatomical structure; In an embodiment of the present invention, a geometric analysis of the vascular anatomical structure is performed on the coronary medical image contrast enhancement data to extract a set of geometric features of the patient's coronary vascular anatomical structure. This step first uses image segmentation technology to effectively separate the blood vessels using a threshold method, a region growing method, or a machine learning algorithm. Subsequently, the extracted blood vessel contours are analyzed to calculate their geometric features, including the diameter, length, curvature, and bifurcation angle of the blood vessels. Three-dimensional reconstruction technology is used to map these geometric features into three-dimensional space to facilitate a comprehensive analysis of the morphological features of the blood vessels, thereby generating a detailed set of geometric features, and ultimately obtaining a set of geometric features of the patient's coronary vascular anatomical structure.

[0030] S15: Perform auxiliary design of a vascular three-dimensional model based on the patient's coronary vascular anatomical structure geometric feature set to generate a three-dimensional model of the patient's coronary vascular anatomical structure.

[0031] In an embodiment of the present invention, the 3D model of the blood vessel is assisted in design based on the set of geometric features of the patient's coronary vascular anatomical structure obtained through previous statistical analysis. This step uses computer-aided design (CAD) software to input the geometric feature data obtained in the previous step into the system for 3D modeling. The 3D model is generated using a modeling tool based on the shape, size and position of the blood vessel. The model may include various branches of the coronary arteries and their features. After the 3D model is completed, it is visualized through the software and combined with finite element analysis tools to evaluate the hemodynamic characteristics, ultimately generating a 3D model of the patient's coronary vascular anatomical structure.

[0032] Furthermore, the vascular anatomical structure geometric analysis of the coronary medical image contrast enhancement data includes: Perform vascular anatomical structure calibration and recognition analysis on the coronary medical image contrast enhancement data to obtain the vascular anatomical structure of the coronary medical image; In an embodiment of the present invention, by calibrating and identifying the vascular anatomical structure of the contrast-enhanced data of the coronary medical image, it is first necessary to use professional medical image processing software, such as OsiriX or 3D Slicer, to pre-process the contrast-enhanced medical image to remove noise and artifacts to improve the image quality, and apply image segmentation technology, select a region growing method or a threshold segmentation algorithm to extract the vascular region from the background. In this process, the image registration technology can be used to align multiple images to ensure the consistency between the images. After the vascular region is extracted, the vascular structure is calibrated and identified, and the morphological processing technology (such as opening and closing operations) is applied to further clarify the vascular boundary, and finally the vascular anatomical structure of the coronary medical image is obtained.

[0033] Preferably, based on the vascular anatomical structure of the coronary medical image, vascular contour edge detection is performed on the corresponding patient's coronary medical image in the coronary medical image contrast enhancement data to obtain the contour boundary of the patient's coronary vascular anatomical structure; In an embodiment of the present invention, edge detection of corresponding vascular contours is performed on the corresponding patient's coronary medical images in the coronary medical image contrast enhancement data in combination with the previously identified vascular anatomical structure of the coronary medical images, and an edge detection algorithm, such as the Canny algorithm, is used to process the preprocessed coronary image data, and the image is smoothed using a Gaussian filter to remove small noise and improve the accuracy of edge detection. The gradient of the image is calculated, and the edge position of the blood vessel is identified through gradient threshold processing. By setting appropriate low and high thresholds, the vascular contour can be effectively extracted to form a clear vascular boundary. After completing the edge detection, a contour tracking algorithm is used to extract a closed vascular contour boundary to ensure that the obtained contour can accurately reflect the patient's coronary vascular anatomical structure, and finally the contour boundary of the patient's coronary vascular anatomical structure is obtained.

[0034] Preferably, the structural geometric features of the vascular anatomical structure of the coronary medical image are calculated based on the contour boundary of the patient's coronary vascular anatomical structure to obtain a geometric feature set of the patient's coronary vascular anatomical structure.

[0035] In an embodiment of the present invention, statistical calculation of vascular structure geometric features is performed on the corresponding coronary medical image vascular anatomical structure by combining the previously extracted coronary vascular anatomical structure contour boundary, and the vascular anatomical structure is three-dimensionally reconstructed based on the boundary using a geometric modeling tool to facilitate calculation of various geometric features. By calculating the length, diameter, bifurcation angle, tangent curvature and other features of the vascular segment, a comprehensive geometric description of the blood vessel is obtained. The specific operations include: applying linear algebra and differential geometry theory to calculate the length of each vascular segment, and obtaining the diameter data of the blood vessel through cross-sectional analysis. For the measurement of the bifurcation angle, the angle and tangent curvature of each bifurcation point are calculated through three-dimensional coordinate points, so as to integrate all calculation results into a patient's coronary vascular anatomical structure geometric feature set, and finally obtain the patient's coronary vascular anatomical structure geometric feature set.

[0036] Furthermore, the calculation of the structural geometric features of the vascular anatomical structure of the coronary medical image based on the contour boundary of the patient's coronary vascular anatomical structure includes: According to the vascular anatomical structure of coronary medical images, the vascular surface is interpolated and reconstructed to obtain the three-dimensional geometric structure diagram of the coronary vascular anatomy; In an embodiment of the present invention, a patient's coronary medical image is acquired by using computed tomography (CT) or magnetic resonance imaging (MRI). The image is first preprocessed, including denoising and contrast enhancement, to improve the clarity of the vascular structure. Next, the image segmentation technology is used, and the threshold segmentation method and the region growing method are applied to accurately extract the anatomical structure of the coronary vessels. Then, the extracted anatomical structure of the coronary vessels is interpolated and reconstructed by a three-dimensional reconstruction algorithm (such as the Marching Cubes algorithm) to generate a complete three-dimensional geometric structure diagram of the coronary vessel anatomy. The reconstruction result is displayed using three-dimensional visualization software, and finally a three-dimensional geometric structure diagram of the coronary vessel anatomy is obtained.

[0037] Preferably, the length of each segment of the coronary vessel is measured based on the contour boundary of the patient's coronary vessel anatomical structure on the three-dimensional geometric structure diagram of the coronary vessel anatomy to obtain the coronary vessel length corresponding to each segment of the coronary vessel; In an embodiment of the present invention, the vascular segments are divided on the corresponding coronary vascular anatomical three-dimensional geometric structure diagram by combining the contour boundaries of the patient's coronary vascular anatomical structure obtained previously to clarify the starting and ending positions of each vascular segment. Then, by using a geometric measurement tool, the length of each coronary vascular segment is calibrated in the three-dimensional model. Specifically, a curve measurement algorithm is used to calculate the length of each segment along the center line of the blood vessel. The measured coronary vascular length data will be recorded as the basic data of the structural characteristics, and finally the coronary vascular length corresponding to each coronary vascular segment is obtained.

[0038] Preferably, the blood vessel measurement cross-sections between the segments in the coronary blood vessel anatomical structure are set according to the coronary blood vessel lengths corresponding to the segments of the coronary blood vessel, and the dynamic diameter measurement is performed on the coronary blood vessel anatomical three-dimensional geometric structure diagram based on the blood vessel measurement cross-sections between the segments to obtain the coronary blood vessel diameters corresponding to the segments of the coronary blood vessel; the tangent curvature of each blood vessel segment in the coronary blood vessel anatomical three-dimensional geometric structure diagram is calculated according to the coronary blood vessel diameters corresponding to the segments of the coronary blood vessel to obtain the coronary blood vessel tangent curvatures corresponding to the segments of the coronary blood vessel; In the embodiment of the present invention, the measurement section inside each section of the coronary artery is set according to the length of the coronary artery corresponding to each section of the coronary artery, ensuring that the section is parallel to the direction of the blood vessel, and by using three-dimensional geometric modeling software, dynamic diameter measurement is performed for each measurement section, and the diameter change of the blood vessel at different positions is dynamically monitored. By calculating the minimum circumscribed circle diameter of the blood vessel on each section, the coronary artery diameter corresponding to each section of the coronary artery is obtained. At the same time, by combining the coronary artery diameter corresponding to each section of the coronary artery obtained by previous measurement, a mathematical method is used to calculate the tangent curvature of each section of the coronary artery, and the parameter equation of each blood vessel segment is extracted. , using the curvature formula in differential geometry to calculate, and using the derivative method to find the tangent vector of each blood vessel segment at different positions , is the derivative of the curve, and the tangent curvature is further obtained , thereby generating a data set containing the tangent curvature corresponding to each segment, and finally obtaining the coronary artery tangent curvature corresponding to each segment of the coronary artery.

[0039] Preferably, based on the coronary vessel lengths corresponding to the coronary vessel segments, the bifurcation angles between each vessel segment in the coronary vessel anatomical three-dimensional geometric structure diagram are measured to obtain the coronary vessel bifurcation angles corresponding to the coronary vessel segments; In an embodiment of the present invention, the bifurcation angle of each segment of the coronary artery is measured by using an angle measurement tool between blood vessel segments in a three-dimensional model. The geometric characteristics of each two adjacent blood vessel segments are analyzed and the angle of the bifurcation point is calculated using a vector method. In the specific implementation process, the coordinate information of the bifurcation point is first extracted, and the angle is solved using the dot product formula between three-dimensional vectors. The measured bifurcation angle data will provide an important basis for evaluating the blood vessel structure and blood flow characteristics, and ultimately the coronary artery bifurcation angle corresponding to each segment of the coronary artery is obtained.

[0040] Preferably, the coronary anatomical structure geometric features of the coronary vessel length, coronary vessel diameter, coronary vessel tangent curvature and coronary vessel bifurcation angle are combined to obtain a set of coronary anatomical structure geometric features of the patient.

[0041] In an embodiment of the present invention, the geometric features of the length, diameter, tangent curvature and bifurcation angle of the coronary artery obtained by previous analysis are merged to form a complete set of geometric features of the coronary anatomical structure. All the above measurement results are summarized and visualized using data analysis software to construct a comprehensive geometric feature data set. This data set will provide basic data support for the hemodynamic simulation analysis after coronary stent implantation, and can effectively evaluate the changes in blood flow under different coronary stent configurations, ultimately obtaining the patient's coronary vascular anatomical structure geometric feature set.

[0042] Furthermore, the bifurcation angle measurement between each blood vessel segment in the three-dimensional geometric structure diagram of the coronary blood vessel anatomy based on the coronary blood vessel length corresponding to each coronary blood vessel segment includes: Identify and locate the bifurcation points between each vascular segment in the three-dimensional geometric structure diagram of the coronary vascular anatomy, and obtain the coronary vascular bifurcation points between each vascular segment in the coronary vascular anatomy; In an embodiment of the present invention, an image processing tool is used to identify and locate bifurcation points between each vascular segment in a three-dimensional geometric structure diagram of the coronary vascular anatomy, so as to generate a three-dimensional model of the coronary artery by using three-dimensional reconstruction software in combination with CT images or MRI data. On this basis, an edge detection method is used through a computer vision algorithm to identify the bifurcation points of the blood vessels. The positioning of these bifurcation points is based on the extraction of geometric features of the coronary artery. By analyzing the topological structure of the blood vessels, the connection relationship between each vascular segment is determined, thereby obtaining complete bifurcation point coordinates, and finally obtaining the coronary vascular bifurcation points between each vascular segment in the coronary vascular anatomy.

[0043] Preferably, a vascular direction vector description analysis is performed on each vascular segment in the three-dimensional geometric structure diagram of the coronary vascular anatomy based on the coronary vascular bifurcation point between each vascular segment in the coronary vascular anatomical structure to obtain a coronary vascular direction description vector corresponding to each coronary vascular segment; In an embodiment of the present invention, after identifying the coronary artery bifurcation point between each vascular segment in the coronary vascular anatomical structure, a directional vector description analysis is then performed on each vascular segment, so as to calculate the coordinate difference between the bifurcation point and the adjacent vascular segment and use vector operations to obtain the directional vector of each vascular segment. In a specific operation, the directional vector can be calculated using the coordinate difference of the midpoint in the three-dimensional coordinate system. After standardization, a directional description vector is formed. This vector not only indicates the direction of the blood vessel, but also provides necessary information for subsequent hemodynamic calculations, and finally the coronary artery directional description vector corresponding to each segment of the coronary artery is obtained.

[0044] Preferably, based on the coronary vessel lengths corresponding to each segment of the coronary vessel, a vessel length vector description analysis is performed between the vessel bifurcation point and the end of the adjacent vessel segment in the coronary vessel anatomical three-dimensional geometric structure diagram to obtain a coronary vessel length description vector corresponding to each segment of the coronary vessel; In an embodiment of the present invention, a description analysis of the vascular length vector between the vascular bifurcation point and the end of the adjacent vascular segment in the three-dimensional geometric structure diagram of the coronary vessel anatomy is performed by combining the coronary vessel lengths corresponding to each segment of the coronary vessel measured previously, so as to obtain the length information by measuring the distance between the bifurcation point and the end of the adjacent vascular segment according to the length of each segment of the coronary vessel, and converting it into a length description vector. This vector will be used for subsequent blood flow simulation to ensure that the flow characteristics of blood flow between different segments are accurately reflected, and finally the coronary vessel length description vector corresponding to each segment of the coronary vessel is obtained.

[0045] Preferably, based on the coronary vessel direction description vector and the coronary vessel length description vector corresponding to each segment of the coronary vessel, a geometric calculation of the bifurcation angle is performed between each vessel segment in the three-dimensional geometric structure diagram of the coronary vessel anatomy to obtain the coronary vessel bifurcation angle corresponding to each segment of the coronary vessel.

[0046] In an embodiment of the present invention, by combining the coronary artery direction description vector and the coronary artery length description vector corresponding to each segment of the coronary artery obtained by previous analysis, a geometric calculation of the bifurcation angle is performed between each corresponding vascular segment, so as to calculate the bifurcation angle using the dot product and cross product formulas of the vectors. Specifically, the direction vectors of the two vascular segments are used to calculate the cosine value of the angle through the dot product, and then the inverse cosine function is used to obtain the specific angle value. The calculation results are sorted to form the bifurcation angle data between the various vascular segments, and finally the coronary artery bifurcation angle corresponding to each segment of the coronary artery is obtained.

[0047] Furthermore, the coronary stent finite element model design module includes the following functions: Obtaining a coronary stent geometric feature set and coronary stent material properties; Based on the coronary stent geometric feature set, the finite element geometric boundary of the corresponding coronary stent is set to generate the finite element geometric boundary conditions of the coronary stent; According to the finite element geometric boundary conditions of the coronary stent, a finite element model design framework of the corresponding coronary stent is constructed to obtain a finite element model design framework of the coronary stent; According to the material characteristics of the coronary stent, the pore and surface roughness constraint analysis of the corresponding coronary stent is performed to obtain the pore and surface roughness constraint conditions of the coronary stent; Based on the constraints of coronary stent porosity and surface roughness, the coronary stent finite element model design framework is refined to generate a coronary stent finite element model.

[0048] As an embodiment of the present invention, refer to Figure 3 As shown, Figure 1 FIG. 1 is a functional flow chart of a coronary stent finite element model design module. In this embodiment, the functions of the coronary stent finite element model design module include: S21: Obtaining the geometric feature set of the coronary stent and the material properties of the coronary stent; In an embodiment of the present invention, by collecting the geometric feature set of the coronary stent, including the diameter, length, supporting structure, pore size and the angular relationship between the stent, computer-aided design (CAD) software (such as SolidWorks or AutoCAD) can be used to perform three-dimensional modeling of the stent to generate accurate geometric feature data. In addition, according to the characteristics of the selected material, it is necessary to obtain the physical and mechanical parameters of the material, including elastic modulus, yield strength, tensile strength and Poisson's ratio. These data can be obtained through laboratory tests, or by referring to standard values ​​in existing literature, and finally the geometric feature set of the coronary stent and the material characteristics of the coronary stent are obtained.

[0049] S22: performing finite element geometric boundary setting on the corresponding coronary stent based on the coronary stent geometric feature set to generate finite element geometric boundary conditions of the coronary stent; In an embodiment of the present invention, the geometric boundary of the corresponding coronary stent is set by using finite element analysis software (such as ANSYS or COMSOL Multiphysics) in combination with the previously obtained coronary stent geometric feature set. First, the three-dimensional model of the stent generated in the CAD software is imported, and the geometric boundary conditions of the stent are defined in the software, including the contact surface of the fixed stent and its contact interface with the surrounding tissue or blood vessel wall. Then, the "Define Boundary Conditions" function is used to set corresponding constraints and loading conditions to ensure that the model can truly reflect the external and internal forces to which the stent is subjected after implantation, so as to form stable finite element geometric boundary conditions, and finally, the finite element geometric boundary conditions of the coronary stent are set and generated.

[0050] S23: constructing a finite element model design framework for the corresponding coronary stent according to the finite element geometric boundary conditions of the coronary stent to obtain a finite element model design framework for the coronary stent; In an embodiment of the present invention, after completing the geometric boundary setting, it is necessary to construct a finite element model design framework of the coronary stent based on these boundary conditions, select a suitable meshing strategy, and mesh the stent according to the complexity of the model and the required analysis accuracy. High-quality hexahedral meshes or tetrahedral meshes can be used for meshing to capture the details of the stent structure, and define material properties in the finite element analysis software. The material properties are combined with the geometric boundary conditions just set to form a complete finite element model design framework, and finally a finite element model design framework for the coronary stent is obtained.

[0051] S24: performing pore and surface roughness constraint analysis on the corresponding coronary stent according to the material characteristics of the coronary stent, and obtaining pore and surface roughness constraint conditions of the coronary stent; In an embodiment of the present invention, the pore and surface roughness constraint analysis of the corresponding coronary stent is performed according to the material properties of the coronary stent. By using finite element analysis software, the porosity parameter is first introduced into the stent model to simulate the influence of tiny pores that may exist in the actual material on the mechanical properties. At the same time, the characteristics of the surface roughness are defined, and a certain roughness constraint is imposed on the contact surface between the stent and the inner wall of the blood vessel by setting a roughness model (such as using Ra or Rz value). These analyses will help identify the influence and constraints of pores and roughness on the behavior of the stent in the biological environment, and finally obtain the pore and surface roughness constraint conditions of the coronary stent.

[0052] S25: Based on the porosity and surface roughness constraints of the coronary stent, the coronary stent finite element model design framework is refined to generate a coronary stent finite element model.

[0053] In an embodiment of the present invention, the finite element model design framework of the coronary stent is refined by combining the porosity and surface roughness constraints of the coronary stent obtained from the previous constraint analysis. In this process, the grid division is further optimized in combination with the constraints obtained in the previous steps to ensure that the grid density in the porosity and roughness feature areas is high to improve the accuracy and stability of the calculation. At the same time, the parameter settings of the material model are adjusted to reflect the nonlinear and anisotropic characteristics of the material in practical applications. The solver is used for simulation calculations to analyze the hemodynamic characteristics, including flow velocity, pressure distribution, and shear stress, to evaluate the functional performance of the coronary stent after implantation and its impact on peripheral blood flow, and finally a complete finite element model of the coronary stent is refined and generated.

[0054] Furthermore, the post-implantation hemodynamic simulation analysis module includes the following functions: Acquire a hemodynamic characteristic parameter set before stent implantation, wherein the hemodynamic characteristic parameter set before stent implantation includes blood flow velocity distribution before stent implantation, blood flow pressure distribution before stent implantation, eddy current intensity distribution before stent implantation, and shear stress distribution before stent implantation; In an embodiment of the present invention, by adopting high-resolution medical imaging technology, such as CT angiography (CTA) or magnetic resonance imaging (MRI), the patient's coronary arteries are imaged to obtain accurate geometric structure data, and by using computational fluid dynamics (CFD) software for simulation, boundary conditions are set and blood is regarded as an incompressible non-Newtonian fluid, and blood flow velocity, pressure, vortex intensity and shear stress are calculated by numerical methods (such as finite element method or finite volume method). The specific operation is to solve the fluid dynamics equations (such as Navier-Stokes equations) under specific flow conditions to obtain the blood flow velocity distribution, pressure distribution, vortex intensity distribution and shear stress distribution before stent implantation, and finally obtain the hemodynamic characteristic parameter set before stent implantation, which includes the blood flow velocity distribution before stent implantation, the blood flow pressure distribution before stent implantation, the vortex intensity distribution before stent implantation and the shear stress distribution before stent implantation.

[0055] Preferably, a blood flow boundary restriction analysis is performed on the hemodynamic characteristic parameter set before stent implantation to generate a patient's coronary blood flow boundary condition; In an embodiment of the present invention, boundary condition analysis is performed based on the hemodynamic characteristic parameter set before stent implantation obtained through previous analysis, so as to generate accurate blood flow boundary conditions, that is, the maximum and minimum values ​​corresponding to the inlet velocity, flow stress and eddy current distribution, by adopting a flow boundary restriction analysis tool and defining the no-slip condition of the blood vessel wall, the inlet flow condition and the outlet pressure condition. This analysis process includes describing the statistical characteristics of the flow velocity and pressure in the blood vessel, and studying the dynamic changes of blood flow under different physiological states in combination with relevant physiological data, so as to ensure that the actual situation can be reasonably reflected in the model, and finally limit the generation of the patient's coronary blood flow boundary conditions.

[0056] Preferably, a dynamic change analysis of blood flow is performed on the three-dimensional model of the patient's coronary vascular anatomical structure based on the patient's coronary blood flow boundary conditions to obtain a dynamic model of blood flow in the coronary vascular anatomical structure; In an embodiment of the present invention, a dynamic flow analysis is performed on a previously constructed three-dimensional model of the patient's coronary vascular anatomical structure by applying the patient's coronary blood flow boundary conditions obtained in combination with the previous analysis to CFD software, the previously generated blood flow boundary conditions are input, and the model is divided into small units using meshing technology to ensure the accuracy of fluid calculations. In the flow dynamic analysis, the flow of blood in the coronary artery is simulated by setting the time step, and the changes in the flow process are recorded, including the time series changes of the velocity field and the pressure field, so as to generate a dynamic blood flow model of the coronary vascular anatomical structure, and finally obtain a dynamic blood flow model of the coronary vascular anatomical structure.

[0057] Preferably, the blood flow dynamics response analysis of the stent implantation is performed on the blood flow dynamics model of the coronary vascular anatomical structure based on the coronary stent finite element model to obtain the blood flow dynamics response distribution field during the stent implantation process; In an embodiment of the present invention, a coupling analysis of stent implantation is performed by combining a previously constructed coronary stent finite element model with a dynamic model of blood flow in the coronary vascular anatomical structure to set the initial position and angle of the stent implantation, and by applying dynamic loads, the dynamic response of blood flow during stent implantation is analyzed. This process uses a time-stepping method to simulate the force of blood flow on the stent and the influence of the stent on blood flow, and ultimately obtains the blood flow dynamic response distribution field during the stent implantation process.

[0058] Preferably, based on the hemodynamic response distribution field of the stent implantation process, a coronary hemodynamic simulation analysis is performed on the coronary stent implantation process corresponding to the blood flow dynamic model of the coronary vascular anatomical structure and the coronary stent finite element model to obtain the hemodynamic simulation distribution field after stent implantation.

[0059] In an embodiment of the present invention, a simulation analysis of the hemodynamics after stent implantation is performed on the coronary stent implantation simulation process corresponding to the blood flow dynamic model of the coronary vascular anatomical structure and the coronary stent finite element model by combining the hemodynamic response distribution field of the stent implantation process obtained by the previous response analysis, so that the blood flow field after implantation is further calculated using CFD software, and the influence of the stent on blood flow velocity, pressure and shear stress is analyzed. By setting a specific calculation area and simulation parameters, the hemodynamic distribution of each part after stent implantation is obtained, and finally the hemodynamic simulation distribution field after stent implantation is simulated.

[0060] Furthermore, the blood flow boundary restriction analysis of the hemodynamic characteristic parameter set before stent implantation includes: According to the blood flow velocity distribution before stent implantation in the hemodynamic characteristic parameter set before stent implantation, the blood flow velocity boundary constraint analysis is performed to obtain the blood flow inlet velocity boundary constraint condition before stent implantation; In an embodiment of the present invention, a boundary constraint analysis is performed on the blood flow velocity distribution before stent implantation obtained after a previous characteristic analysis, so as to perform numerical simulation by using a computational fluid dynamics (CFD) tool, establish a three-dimensional blood vessel model, and apply appropriate fluid dynamics equations (such as the Navier-Stokes equations) for solving. During the simulation process, boundary conditions need to be set at the blood vessel entrance to ensure that they are consistent with the actual physiological state. By analyzing the velocity field, the flow velocity value at a specific position is extracted to form boundary constraint conditions for the blood flow entrance velocity. These boundary conditions will be used for subsequent flow simulations to ensure that the blood flow state after stent implantation is consistent with the actual situation, and finally obtain the boundary constraint conditions for the blood flow entrance velocity before stent implantation.

[0061] Preferably, based on the blood flow pressure distribution before stent implantation in the hemodynamic characteristic parameter set before stent implantation, the shear stress distribution before stent implantation is subjected to a vascular wall flow force boundary constraint analysis to obtain a vascular inner wall flow stress boundary constraint condition before stent implantation; In the embodiment of the present invention, after completing the boundary constraint conditions of the blood flow velocity distribution, the blood flow pressure distribution before stent implantation is further analyzed. First, the blood flow pressure data is obtained through the early CFD simulation. The data is recorded at each point in the blood vessel. On this basis, the corresponding shear stress distribution is calculated. The calculation formula of the shear stress is: ,in is the shear stress, is the viscosity of the fluid, It is the flow velocity gradient. By setting appropriate boundary conditions on the inner wall of the blood vessel, the flow stress distribution is determined, and then the boundary constraint conditions of the flow stress on the inner wall of the blood vessel are obtained, and finally the boundary constraint conditions of the flow stress on the inner wall of the blood vessel before stent implantation are obtained.

[0062] Preferably, a blood vortex distribution boundary constraint analysis is performed based on the vortex intensity distribution before stent implantation in the hemodynamic characteristic parameter set before stent implantation to obtain a blood vortex distribution boundary constraint condition before stent implantation; In the embodiment of the present invention, the eddy current intensity distribution in the hemodynamic characteristic parameter set before stent implantation is analyzed. The eddy current intensity is an important parameter for evaluating blood flow characteristics and is usually generated by vortices in fluid motion. In the CFD model, the velocity field is solved and the eddy current intensity calculation formula (such as: ), the vortex intensity distribution in the blood flow can be obtained, and after the vortex distribution is determined, a boundary constraint analysis is performed to ensure that the boundary conditions of the vortex distribution are accurately captured under the flow state before stent implantation. These boundary conditions will help simulate the impact of stent implantation on blood flow in subsequent flow analysis, and finally obtain the boundary constraint conditions of the blood vortex distribution before stent implantation.

[0063] Preferably, the boundary constraints of blood flow inlet velocity before stent implantation, blood vessel inner wall flow stress before stent implantation and blood eddy flow distribution before stent implantation are merged to generate the patient's coronary blood flow boundary conditions.

[0064] In an embodiment of the present invention, the blood flow inlet velocity boundary constraint conditions, inner wall flow stress boundary constraint conditions and blood vortex distribution boundary constraint conditions obtained in the above steps are merged. This merging process uses a numerical algorithm to integrate the three sets of boundary conditions into a unified boundary condition set to facilitate subsequent numerical simulation analysis. In actual operation, numerical processing tools (such as MATLAB or Python) are used for data processing and analysis, and the fusion of boundary conditions is achieved through appropriate algorithms (for example, linear weighted or nonlinear optimization methods), that is, the maximum and minimum values ​​corresponding to the inlet velocity, flow stress and vortex distribution, to provide a comprehensive flow state description for subsequent coronary stent implantation simulation, ensure the accuracy and reliability of the simulation results, and finally merge to generate the patient's coronary blood flow boundary conditions.

[0065] Furthermore, the blood flow status assessment module before and after implantation includes the following functions: Performing a post-stent implantation dynamics characteristic analysis on the post-stent implantation hemodynamics simulation distribution field to obtain a post-stent implantation hemodynamics characteristic parameter set, wherein the post-stent implantation hemodynamics characteristic parameter set includes a post-stent implantation blood flow velocity distribution, a post-stent implantation blood flow pressure distribution, a post-stent implantation eddy current intensity distribution, and a post-stent implantation shear stress distribution; In an embodiment of the present invention, by using computational fluid dynamics (CFD) software, such as ANSYS Fluent or COMSOL Multiphysics, a statistical analysis of the hemodynamic characteristics of the hemodynamic simulation distribution field after stent implantation generated by the previous simulation is performed to implant the stent model accordingly, adjust the contact relationship between the geometric parameters of the stent and the blood vessel wall, and set boundary conditions, including blood inflow velocity and pressure, to perform numerical simulation calculations to obtain parameters such as blood flow velocity distribution, pressure distribution, eddy current intensity distribution, and shear stress distribution after stent implantation. The calculation results are visualized through post-processing tools to generate a corresponding distribution field map, clearly mark the hemodynamic characteristics of each area, and finally obtain a set of hemodynamic characteristic parameters after stent implantation, including blood flow velocity distribution after stent implantation, blood flow pressure distribution after stent implantation, eddy current intensity distribution after stent implantation, and shear stress distribution after stent implantation.

[0066] Preferably, based on the hemodynamic characteristic parameter set before stent implantation, a hemodynamic evaluation calculation formula before and after stent implantation is used to perform blood flow evaluation calculation on the hemodynamic characteristic parameter set after stent implantation to obtain a hemodynamic state evaluation value before and after stent implantation; In an embodiment of the present invention, a suitable hemodynamic evaluation calculation formula before and after stent implantation is constructed by combining the time variable parameters of blood flow evaluation calculation, the time difference between before and after stent implantation, the blood flow velocity distribution after stent implantation, the blood flow velocity distribution before stent implantation, the blood flow pressure distribution after stent implantation, the blood flow pressure distribution before stent implantation, the eddy current intensity distribution after stent implantation, the eddy current intensity distribution before stent implantation, the shear stress distribution after stent implantation, the shear stress distribution before stent implantation and related parameters to perform blood flow evaluation calculation on the hemodynamic characteristic parameter set after stent implantation. The core of this step is to compare the changes in parameters before and after, calculate the corresponding evaluation values, and finally obtain the hemodynamic state evaluation values ​​before and after stent implantation.

[0067] Preferably, the blood flow status evaluation and analysis before and after stent implantation is performed based on the hemodynamic status evaluation values ​​before and after stent implantation to generate a blood flow status simulation evaluation report before and after stent implantation.

[0068] In an embodiment of the present invention, a detailed blood flow status evaluation and analysis is performed after obtaining the hemodynamic status evaluation values ​​before and after stent implantation. This process requires systematic comparison and analysis of the evaluation values ​​to extract key features, such as the percentage change in blood flow velocity, the range of pressure change, the increase or decrease in eddy current intensity, and the effect of shear stress on the inner wall of the blood vessel. By drawing comparison charts or data tables, the change trends before and after implantation are clearly presented, and professional chart software (such as Origin or Excel) is used for data visualization. At the same time, combined with clinical standards and data, a systematic simulation evaluation report is formed to describe in detail the impact of stent implantation on the blood flow status, possible clinical significance and follow-up observation suggestions. The generated report provides a basis for clinical decision-making, ensures that the blood flow status after stent implantation is effectively evaluated and monitored, and finally analyzes and generates a corresponding simulation evaluation report on the blood flow status before and after stent implantation.

[0069] Furthermore, the hemodynamic evaluation calculation formula before and after stent implantation is specifically as follows: ; In the formula, It is the hemodynamic status assessment value before and after stent implantation. The starting time point for blood flow assessment calculation, The end time point calculated for blood flow assessment, is the time variable parameter, is the time difference between before and after stent implantation, For in time Blood flow velocity distribution after stent implantation at For in time Blood flow velocity distribution before stent implantation at For in time Blood flow pressure distribution after stent implantation, For in time Blood flow pressure distribution before stent implantation at For in time The eddy current intensity distribution after stent implantation at For in time The eddy current intensity distribution before stent implantation at For in time Shear stress distribution after stent implantation, For in time Shear stress distribution before stent implantation.

[0070] The present invention obtains a hemodynamic evaluation calculation formula before and after stent implantation by using a specific mathematical model and after verification, which is used to perform blood flow evaluation calculation on the hemodynamic characteristic parameter set after stent implantation. The formula fully considers the hemodynamic state evaluation value before and after stent implantation. , the starting time point for blood flow assessment calculation , the end time point of blood flow assessment calculation , time variable parameter , the time difference between before and after stent implantation , at time Blood flow velocity distribution after stent implantation , at time Blood flow velocity distribution before stent implantation , at time Blood flow pressure distribution after stent implantation , at time Blood flow pressure distribution before stent implantation , at time Distribution of eddy current intensity after stent implantation , at time Eddy current intensity distribution before stent implantation , at time Shear stress distribution after stent implantation , at time Shear stress distribution before stent implantation , according to the hemodynamic status evaluation value before and after stent implantation The correlation between the above parameters forms a functional relationship: ; The calculation formula for hemodynamic evaluation before and after stent implantation takes into account multiple important hemodynamic characteristics, including blood flow velocity, blood flow pressure, eddy current intensity and shear stress. This comprehensive analysis helps to fully understand the impact of stent implantation on blood flow characteristics and avoid one-sidedness. By introducing the time variable into the formula (for example, and ), which can dynamically capture the changes in blood flow characteristics, making the evaluation more accurate and able to reflect the hemodynamic changes before and after stent implantation. The formula calculates the evaluation value by integration ( ), which can provide a quantitative indicator to facilitate clinicians or researchers to compare and analyze the blood flow status before and after stent implantation. This quantitative method helps to clarify the effectiveness and safety of the stent. By analyzing the hemodynamic changes before and after stent implantation, adverse changes in blood flow (such as eddy currents, abnormal pressure distribution, etc.) can be found, thereby providing a basis for the optimization of stent design. This feedback mechanism can help develop coronary stents that are more in line with physiological needs. In addition, the formula can realize the blood flow evaluation calculation process of the hemodynamic characteristic parameter set after stent implantation, thereby improving the accuracy and applicability of the hemodynamic evaluation calculation formula before and after stent implantation.

[0071] Therefore, the embodiments should be regarded as illustrative and non-restrictive from all points, and the scope of the present invention is limited by the appended claims rather than the above description, and it is therefore intended that all changes falling within the meaning and range of equivalent elements of the application documents are included in the present invention.

[0072] The above description is only a specific embodiment of the present invention, so that those skilled in the art can understand or implement the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but should conform to the widest scope consistent with the principles and novel features invented herein.

Claims

1. A hemodynamic simulation analysis system for coronary stent implantation, characterized in that: Includes the following modules: The coronary vascular anatomical structure auxiliary design module is used to obtain the patient's coronary medical imaging data, and perform vascular anatomical structure geometric analysis on the patient's coronary medical imaging data to obtain the patient's coronary vascular anatomical structure geometric feature set; perform vascular three-dimensional model auxiliary design based on the patient's coronary vascular anatomical structure geometric feature set to generate a three-dimensional model of the patient's coronary vascular anatomical structure; A coronary stent finite element model design module is used to obtain a coronary stent geometric feature set and coronary stent material properties, and perform a stent finite element model design on the corresponding coronary stent based on the coronary stent geometric feature set and coronary stent material properties to generate a coronary stent finite element model; A post-implantation hemodynamic simulation analysis module is used to obtain a hemodynamic characteristic parameter set before stent implantation and perform a blood flow boundary restriction analysis on the hemodynamic characteristic parameter set before stent implantation to generate a patient's coronary blood flow boundary condition; Based on the patient's coronary blood flow boundary conditions, the patient's coronary vascular anatomical structure three-dimensional model and the coronary stent finite element model are used to perform coronary stent implantation dynamics simulation analysis to obtain the hemodynamic simulation distribution field after stent implantation; The blood flow status evaluation module before and after implantation is used to evaluate and analyze the blood flow status before and after stent implantation based on the hemodynamic characteristic parameter set before stent implantation and the hemodynamic simulation distribution field after stent implantation to generate a blood flow status simulation evaluation report before and after stent implantation.

2. The hemodynamic simulation analysis system for coronary stent implantation according to claim 1, characterized in that: The coronary vascular anatomical structure auxiliary design module includes the following functions: Obtain the patient's coronary medical imaging data; Performing image denoising on the patient's coronary medical image data to obtain coronary medical image denoising data; Performing image contrast enhancement processing on the denoised coronary medical image data to obtain coronary medical image contrast enhanced data; Performing vascular anatomical structure geometric analysis on coronary medical image contrast enhancement data to obtain a set of geometric feature sets of the patient's coronary vascular anatomical structure; A three-dimensional vascular model is assisted in designing the vascular model according to the geometric feature set of the patient's coronary vascular anatomical structure to generate a three-dimensional model of the patient's coronary vascular anatomical structure.

3. The hemodynamic simulation analysis system for coronary stent implantation according to claim 2, characterized in that: The vascular anatomical structure geometric analysis of the coronary medical image contrast enhancement data includes: Perform vascular anatomical structure calibration and recognition analysis on the coronary medical image contrast enhancement data to obtain the vascular anatomical structure of the coronary medical image; Based on the vascular anatomical structure of the coronary medical image, the vascular contour edge detection is performed on the corresponding patient's coronary medical image in the coronary medical image contrast enhancement data to obtain the contour boundary of the patient's coronary vascular anatomical structure; The structural geometric features of the vascular anatomical structure of the coronary medical image are calculated based on the contour boundary of the patient's coronary vascular anatomical structure to obtain a geometric feature set of the patient's coronary vascular anatomical structure.

4. The hemodynamic simulation analysis system for coronary stent implantation according to claim 3, characterized in that: The calculation of the structural geometric features of the vascular anatomical structure of the coronary medical image based on the contour boundary of the patient's coronary vascular anatomical structure includes: According to the vascular anatomical structure of coronary medical images, the vascular surface is interpolated and reconstructed to obtain the three-dimensional geometric structure diagram of the coronary vascular anatomy; Based on the contour boundary of the patient's coronary vascular anatomical structure, the length of each segment of the coronary vascular anatomical three-dimensional geometric structure diagram is measured to obtain the coronary vascular length corresponding to each segment of the coronary vascular; The vascular measurement cross-sections between the segments in the coronary vascular anatomical structure are set according to the coronary vascular lengths corresponding to the segments of the coronary vascular, and the dynamic diameter measurement is performed on the coronary vascular anatomical three-dimensional geometric structure diagram based on the vascular measurement cross-sections between the segments to obtain the coronary vascular diameters corresponding to the segments of the coronary vascular; the tangent curvature of each vascular segment in the coronary vascular anatomical three-dimensional geometric structure diagram is calculated according to the coronary vascular diameters corresponding to the segments of the coronary vascular, to obtain the coronary vascular tangent curvature corresponding to the segments of the coronary vascular; Based on the coronary vessel lengths corresponding to each segment of the coronary artery, the bifurcation angles between each segment of the coronary artery in the three-dimensional geometric structure diagram of the coronary artery anatomy are measured to obtain the coronary artery bifurcation angles corresponding to each segment of the coronary artery; The coronary anatomical structure geometric features of the coronary vessel length, coronary vessel diameter, coronary vessel tangent curvature and coronary vessel bifurcation angle are merged to obtain the patient's coronary anatomical structure geometric feature set.

5. The hemodynamic simulation analysis system for coronary stent implantation according to claim 4, characterized in that: The method of measuring the bifurcation angle between each blood vessel segment in the three-dimensional geometric structure diagram of the coronary blood vessel anatomy based on the coronary blood vessel length corresponding to each coronary blood vessel segment includes: Identify and locate the bifurcation points between each vascular segment in the three-dimensional geometric structure diagram of the coronary vascular anatomy, and obtain the coronary vascular bifurcation points between each vascular segment in the coronary vascular anatomy; Based on the coronary bifurcation points between each vascular segment in the coronary vascular anatomical structure, a vascular direction vector description analysis is performed on each vascular segment in the coronary vascular anatomical three-dimensional geometric structure diagram to obtain the coronary vascular direction description vector corresponding to each coronary vascular segment; Based on the coronary artery length corresponding to each segment of the coronary artery, a vascular length vector description analysis is performed between the vascular bifurcation point and the end of the adjacent vascular segment in the coronary vascular anatomical three-dimensional geometric structure diagram to obtain the coronary artery length description vector corresponding to each segment of the coronary artery; Based on the coronary artery direction description vector and the coronary artery length description vector corresponding to each segment of the coronary artery, the bifurcation angle geometry calculation is performed between each segment of the coronary artery in the three-dimensional geometric structure diagram of the coronary artery anatomy to obtain the coronary artery bifurcation angle corresponding to each segment of the coronary artery.

6. The hemodynamic simulation analysis system for coronary stent implantation according to claim 1, characterized in that: The coronary stent finite element model design module includes the following functions: Obtaining a coronary stent geometric feature set and coronary stent material properties; Based on the coronary stent geometric feature set, the finite element geometric boundary of the corresponding coronary stent is set to generate the finite element geometric boundary conditions of the coronary stent; According to the finite element geometric boundary conditions of the coronary stent, a finite element model design framework of the corresponding coronary stent is constructed to obtain a finite element model design framework of the coronary stent; According to the material characteristics of the coronary stent, the pore and surface roughness constraint analysis of the corresponding coronary stent is performed to obtain the pore and surface roughness constraint conditions of the coronary stent; Based on the constraints of coronary stent porosity and surface roughness, the coronary stent finite element model design framework is refined to generate a coronary stent finite element model.

7. The hemodynamic simulation analysis system for coronary stent implantation according to claim 1, characterized in that: The post-implantation hemodynamic simulation analysis module includes the following functions: Acquire a hemodynamic characteristic parameter set before stent implantation, wherein the hemodynamic characteristic parameter set before stent implantation includes blood flow velocity distribution before stent implantation, blood flow pressure distribution before stent implantation, eddy current intensity distribution before stent implantation, and shear stress distribution before stent implantation; Performing blood flow boundary restriction analysis on the hemodynamic characteristic parameter set before stent implantation to generate the patient's coronary blood flow boundary conditions; Based on the patient's coronary blood flow boundary conditions, the patient's coronary vascular anatomical structure three-dimensional model is analyzed for blood flow dynamic changes, and a coronary vascular anatomical structure blood flow dynamic model is obtained; Based on the finite element model of coronary stent, the blood flow dynamic model of the coronary vascular anatomical structure is analyzed to analyze the blood flow dynamic response during stent implantation, and the blood flow dynamic response distribution field during stent implantation is obtained; Based on the hemodynamic response distribution field of the stent implantation process, the coronary hemodynamic simulation analysis of the coronary stent implantation process corresponding to the blood flow dynamic model of the coronary vascular anatomical structure and the coronary stent finite element model was performed to obtain the hemodynamic simulation distribution field after stent implantation.

8. The hemodynamic simulation analysis system for coronary stent implantation according to claim 7, characterized in that: The blood flow boundary restriction analysis of the hemodynamic characteristic parameter set before stent implantation includes: According to the blood flow velocity distribution before stent implantation in the hemodynamic characteristic parameter set before stent implantation, the blood flow velocity boundary constraint analysis is performed to obtain the blood flow inlet velocity boundary constraint condition before stent implantation; Based on the blood flow pressure distribution before stent implantation in the hemodynamic characteristic parameter set before stent implantation, the shear stress distribution before stent implantation is analyzed by the boundary constraint of the blood vessel wall flow force, and the boundary constraint condition of the blood vessel inner wall flow stress before stent implantation is obtained; According to the eddy current intensity distribution before stent implantation in the hemodynamic characteristic parameter set before stent implantation, a blood eddy current distribution boundary constraint analysis is performed to obtain the blood eddy current distribution boundary constraint conditions before stent implantation; The boundary conditions of blood flow inlet velocity before stent implantation, blood vessel inner wall flow stress before stent implantation and blood eddy flow distribution before stent implantation are merged to generate the patient's coronary blood flow boundary conditions.

9. The hemodynamic simulation analysis system for coronary stent implantation according to claim 1, characterized in that: The blood flow status assessment module before and after implantation includes the following functions: Performing a post-stent implantation dynamics characteristic analysis on the post-stent implantation hemodynamics simulation distribution field to obtain a post-stent implantation hemodynamics characteristic parameter set, wherein the post-stent implantation hemodynamics characteristic parameter set includes a post-stent implantation blood flow velocity distribution, a post-stent implantation blood flow pressure distribution, a post-stent implantation eddy current intensity distribution, and a post-stent implantation shear stress distribution; Based on the hemodynamic characteristic parameter set before stent implantation, a hemodynamic evaluation calculation formula before and after stent implantation is used to perform blood flow evaluation calculation on the hemodynamic characteristic parameter set after stent implantation to obtain the hemodynamic state evaluation value before and after stent implantation; The blood flow status before and after stent implantation is evaluated and analyzed based on the hemodynamic status evaluation values ​​before and after stent implantation to generate a blood flow status simulation evaluation report before and after stent implantation.

10. The hemodynamic simulation analysis system for coronary stent implantation according to claim 9, characterized in that: The hemodynamic evaluation calculation formula before and after stent implantation is specifically: ； In the formula, It is the hemodynamic status assessment value before and after stent implantation. The starting time point for blood flow assessment calculation, The end time point calculated for blood flow assessment, is the time variable parameter, is the time difference between before and after stent implantation, For in time Blood flow velocity distribution after stent implantation at For in time Blood flow velocity distribution before stent implantation at For in time Blood flow pressure distribution after stent implantation, For in time Blood flow pressure distribution before stent implantation at For in time The eddy current intensity distribution after stent implantation at For in time The eddy current intensity distribution before stent implantation at For in time Shear stress distribution after stent implantation, For in time Shear stress distribution before stent implantation.

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