Health-care food for regulating blood sugar and blood fat and preparation method of health-care food

Abstract

The invention discloses a health-care food for regulating blood sugar and blood fat and a preparation method of the health-care food. The health food comprises the following components in parts by weight: 10-20 parts of eucheuma gelatinae polysaccharide, 10-20 parts of pycnoporus sanguineus extract, 5-10 parts of maltodextrin, 6-12 parts of blueberry fruit powder and 15-30 parts of microcrystalline cellulose. The research finds that the pycnoporus sanguineus extract, especially the pycnoporus sanguineus polysaccharide extract, can remarkably improve the blood sugar and blood fat reducing effects of the eucheuma gelatinae polysaccharide, and the pycnoporus sanguineus extract and the pycnoporus sanguineus polysaccharide extract are combined for use, so that a novel health food is expected to be developed and applied to the aspects of reducing blood sugar and blood fat.

Description

Technical Field

[0001] The present invention belongs to the field of health-care foods, and in particular relates to a health-care food for regulating blood sugar and blood lipids and a preparation method thereof. Background Art

[0002] In today's society, the incidence of diabetes and hyperlipidemia has been increasing year by year and has become a global public health problem. Diabetes is a metabolic disease characterized by high blood sugar. Common symptoms include polydipsia, polyphagia, polyuria, and weight loss. Diabetes can be divided into type 1 diabetes (insulin-dependent diabetes), type 2 diabetes (non-insulin-dependent diabetes), gestational diabetes, and other types of diabetes. Type 2 diabetes is caused by the inability of insulin to bind to or is blocked by the receptor. The pathogenesis of more than 90% of diabetic patients is attributed to this type of insulin resistance. Existing diabetes treatments mainly rely on insulin injections and oral medications such as sulfonylureas and biguanides, but these drugs have problems such as poor efficacy, many side effects, and are prone to allergic reactions and gastrointestinal irritation symptoms. In addition, improper use of injected insulin drugs may also cause hypoglycemia reactions and easily lead to patient dependence on drugs, with unsatisfactory efficacy.

[0003] Hyperlipidemia is a systemic disease, which refers to excessively high levels of cholesterol (TC) and / or triglycerides (TG) in the blood, or excessively low levels of high-density lipoprotein cholesterol (HDL-C). Modern medicine calls it dyslipidemia. The direct damage of hyperlipidemia is the acceleration of systemic atherosclerosis, leading to cardiovascular and cerebrovascular diseases, such as coronary heart disease and myocardial infarction. Studies have shown that hyperlipidemia is an important risk factor for diseases such as stroke and coronary heart disease. At present, the main drugs for the treatment of hyperlipidemia are statins, but long-term use of these drugs may cause side effects such as increased transaminase and muscle dissolution, and may increase the risk of type 2 diabetes. Therefore, it is particularly important to develop a health food that is safe to eat and effectively regulates blood sugar and blood lipids.

[0004] Eucheuma gelatinae is a large, economical marine algae belonging to the Rhodophyta and Solieriaceae families. It is cultivated on a large scale on Hainan Island in my country and is a very abundant resource. Eucheuma gelatinae is rich in polysaccharides, primarily composed of galactose, with smaller amounts of glucose, xylose, talose, and idose. Recent studies have demonstrated that Eucheuma gelatinae polysaccharides exhibit biological activities such as hypoglycemic and hypolipidemic effects, as well as antiviral and antitumor effects. The biological activities of Eucheuma gelatinae polysaccharides are often influenced by their composition, structure, and conformation. Shi Shuo et al. studied the structure of Eucheuma polysaccharides and the hypoglycemic activity of crude and purified fractions. The results showed that the purified fraction (EGP-3) of Eucheuma polysaccharides had superior hypoglycemic activity compared to the other purified fractions (EGP-1 and EGP-2) and crude Eucheuma polysaccharides (EGP) (Isolation, Purification, Structural Characterization, and Hypoglycemic Activity of Eucheuma Polysaccharides [J]. Journal of Dalian Ocean University). However, the EGP-3 fraction was significantly less effective at lowering blood sugar than the traditional hypoglycemic drug acarbose.

[0005] Pycnoporus sanguineus, also known as red thrombus or red blood fungus, is a large fungus belonging to the phylum Basidiomycota and family Polyporaceae. Artificial cultivation is currently possible, with large-scale production achieved through methods such as basswood cultivation, substitute cultivation, liquid fermentation, and dual-phase fermentation. Limited research has been conducted on the activities of Pycnoporus sanguineus. Previous studies have found it to have immune-enhancing, tumor-suppressing, and enteritis-treating properties. However, there are no studies or reports on the effects of Pycnoporus sanguineus extracts on regulating blood sugar and lipids. Summary of the Invention

[0006] The present invention aims to provide a health food that is safe and effective in regulating blood sugar and blood lipids. Research has found that extracts from Pycnoporus sanguineus, particularly polysaccharide extracts from Pycnoporus sanguineus, can significantly enhance the hypoglycemic and hypolipidemic effects of Eucheuma truncatum polysaccharides. Combining these two extracts could potentially lead to the development of a new health food for lowering blood sugar and blood lipids.

[0007] The technical solution of the present invention is:

[0008] A health food for regulating blood sugar and blood lipids comprises, by weight, 10-20 parts of Eucheuma polysaccharide, 10-20 parts of Pycnoporus sanguineum extract, 5-10 parts of maltodextrin, 6-12 parts of blueberry powder and 15-30 parts of microcrystalline cellulose.

[0009] The Eucheuma polysaccharide is Eucheuma polysaccharide EGP-3.

[0010] The weight average molecular weight M of the polysaccharide EGP-3 of Eucheuma truncatum w The number average molecular weight is 698KDa. n The molecular weight of the oligonucleotide is 69.7 KDa and the polydispersity index is 10.01.

[0011] The described Eucheuma polysaccharide EGP-3 was prepared with reference to the following literature: Shi Shuo et al. Isolation, purification, structural characterization and hypoglycemic activity of Eucheuma polysaccharide [J]. Journal of Dalian Ocean University. 2023, 38(05).

[0012] The Pycnoporus sanguineum extract is a Pycnoporus sanguineum polysaccharide extract.

[0013] The preparation steps of the polysaccharide extract of P. sanguinosa are as follows: crushing the fruiting bodies of P. sanguinosa, extracting with hot water, filtering, extracting the filter residue with hot water again, filtering, combining the filtrate, concentrating the filtrate, adding ethanol to the concentrated solution for precipitation, dissolving the precipitate in water, filtering with a filter membrane, collecting the filtrate, adding ethanol to the filtrate for precipitation again, re-dissolving the collected precipitate in water, and freeze-drying to obtain the polysaccharide extract of P. sanguinosa.

[0014] Specifically, the preparation steps of the polysaccharide extract of P. sanguinosa are as follows: crushing the fruiting body of P. sanguinosa, adding purified water at a material-liquid ratio of 90-100 g / L, extracting at 80-90° C. for 1-2 hours, filtering, extracting the filter residue with hot water for 1-2 hours, filtering, combining the filtrate, concentrating the filtrate, adding ethanol to the concentrate to make the final concentration of ethanol 70-80% by volume, standing overnight, taking the precipitate and dissolving it in water, filtering with a 0.22 μm filter membrane, collecting the filtrate, adding ethanol to the filtrate for precipitation again, collecting the precipitate and re-dissolving it with water, and freeze-drying to obtain the polysaccharide extract of P. sanguinosa.

[0015] The health food for regulating blood sugar and blood lipids of the present invention is prepared by the following method, comprising the following steps: uniformly mixing Eucheuma polysaccharide, Pycnoporus sanguineum extract, blueberry fruit powder, maltodextrin and microcrystalline cellulose, adding an appropriate amount of ethanol solution to prepare a soft material, sieving and granulating, drying, and sieving the whole granules to obtain the product.

[0016] Preferably, the sieving granulation is through a 16-mesh sieve, and the sieving granulation is through a 12-mesh sieve.

[0017] Preferably, the drying is carried out at 60°C.

[0018] The health food for regulating blood sugar and blood lipids of the present invention can be used for lowering blood sugar and blood lipids.

[0019] The present invention has the following beneficial effects:

[0020] The present invention discovered that a polysaccharide extract from P. sanguinea has the ability to regulate blood sugar and blood lipids. Combining this polysaccharide extract with the polysaccharide EGP-3 from Eucheuma truncatum significantly enhances the blood sugar and blood lipid-lowering effects of EGP-3. Experiments have shown that a health food containing both the polysaccharide extract from P. sanguinea and the polysaccharide EGP-3 has a blood sugar-lowering effect comparable to that of glibenclamide, but a blood lipid-lowering effect superior to that of glibenclamide. Therefore, this health food has promising application prospects for its potential in lowering both blood sugar and blood lipids. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 The health food of the present invention reduces the blood glucose concentration of type Ⅱ diabetes model mice. Compared with the blank group, *** p<0.001; compared with the model group, # p<0.05, ## p<0.01, ### p<0.001.

[0022] Figure 2 The health food of the present invention reduces the levels of serum triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in type 2 diabetes model mice. Compared with the blank group, *** p<0.001; compared with the model group, # p<0.05, ## p<0.01, ### p<0.001. DETAILED DESCRIPTION

[0023] The following examples are provided to further illustrate the present invention, but are not intended to limit the present invention.

[0024] Example 1

[0025] Preparation of crude polysaccharide EGP-3 from Eucheuma chinensis:

[0026] (1) Clean the Eucheuma truncatum, dry it, crush it, and pass it through an 80-mesh sieve to obtain Eucheuma truncatum dry powder. Weigh about 2 g of Eucheuma truncatum powder, add ultrapure water, and adjust the solid-liquid ratio to 1 g / 100 mL. Adjust the pH to 5.0, treat it at an ultrasonic power of 234 W for 33 min, add 1% of the mass of Eucheuma truncatum powder (papain and cellulase mixed in a mass ratio of 2:1), enzymolyze it at 67 ° C for 1.5 h, inactivate the enzyme, centrifuge it at 10000 r / min for 15 min, take the supernatant, and then perform rotary evaporation and concentration to obtain a concentrate; add 95% ethanol by volume to the concentrate to make the final ethanol concentration be 75% by volume, let it stand at 4 ° C overnight, centrifuge to take the precipitate, and freeze-dry to obtain crude polysaccharide.

[0027] (2) DEAE-52 cellulose was activated and wet packed into a column (2.6 cm × 50 cm) and equilibrated with 3 column volumes of ultrapure water. 120 mg of the crude polysaccharide prepared above was dissolved in 20 mL of ultrapure water and loaded into the packed DEAE-52 cellulose column. Ultrapure water and 0.2, 0.4, 0.6, 0.8, and 1.0 mol / L NaCl concentrations were used for elution, respectively. 5 mL of eluate was collected per tube, and 40 tubes were collected for each concentration. The phenol-sulfuric acid method was used for tracing, and the elution curve was plotted with the tube number as the abscissa and the absorbance at 490 nm as the ordinate. According to the elution curve, the 1.0 mol / L NaCl eluate was collected, the eluate was concentrated by rotary evaporation, and then dialyzed for 48 h at 4°C in a dialysis bag with a molecular weight cutoff of 200 Da to remove the salt component. The purified polysaccharide EGP-3 from Eucheuma chinensis was obtained by freeze-drying.

[0028] Example 2

[0029] Preparation of Pycnoporus sanguineum polysaccharide extract:

[0030] The fruiting bodies of P. sanguinosa were crushed, passed through a 40-mesh sieve, and purified water was added at a material-liquid ratio of 100 g / L. The mixture was extracted at 85°C for 1.5 hours and filtered. The filter residue was further extracted with hot water for 1.5 hours, filtered, and the filtrates were combined and concentrated by rotary evaporation to obtain a concentrate. Ethanol was added to the concentrate to make the final concentration of ethanol 75% by volume. The solution was allowed to stand at 4°C overnight and centrifuged to obtain a precipitate. The precipitate was dissolved in water and filtered through a 0.22 μm filter membrane. The filtrate was collected. Ethanol was added to the filtrate to make the final concentration of ethanol 75% by volume and precipitated again. The precipitate was centrifuged and redissolved in water. The precipitate was freeze-dried to obtain a P. sanguinosa polysaccharide extract.

[0031] Example 3

[0032] Preparation of Pycnoporus sanguineus ethanol extract:

[0033] The fruiting bodies of P. sanguineus were crushed and passed through a 40-mesh sieve. An 80% ethanol aqueous solution with a volume fraction of 40 times the weight of the fruiting body powder was added. The mixture was heated and refluxed at 85°C for 1.5 h. The mixture was filtered and the filtrate was collected. The above heating and reflux operation was repeated once for the residue. The two filtrates were combined, concentrated under reduced pressure at 50°C until there was no ethanol smell, and freeze-dried to obtain the ethanol extract of P. sanguineus.

[0034] Example 4

[0035] Determination of α-glucosidase inhibitory activity:

[0036] 1. Sample solution preparation:

[0037] 1) Dissolving the purified polysaccharide EGP-3 from Eucheuma truncatum in water to prepare a solution with a concentration of 0.5 mg / mL;

[0038] 2) dissolving the polysaccharide extract of Pycnoporus sanguineus in water to prepare a solution with a concentration of 0.5 mg / mL;

[0039] 3) dissolving the ethanol extract of P. sanguineus in DMSO to prepare a solution with a concentration of 0.5 mg / mL;

[0040] 4) Dissolving the purified polysaccharide EGP-3 from Eucheuma truncatum and the polysaccharide extract from Pycnoporus sanguineus in water to prepare a solution with a concentration of 0.5 mg / mL for both components;

[0041] 5) Dissolve the purified polysaccharide EGP-3 from Eucheuma truncatum and the ethanol extract of Pycnoporus sanguineus in DMSO to prepare a solution with a concentration of 0.5 mg / mL for both components;

[0042] 6) Dissolving acarbose in water to prepare a solution with a concentration of 0.5 mg / mL;

[0043] 2. Prepare a 2.5 μmol / L PNPG solution, a 0.2 mol / L Na₂CO₃ solution, and a 0.2 U / mL α-glucosidase solution. Pipette 1.2 mL of 0.1 mol / L phosphate buffer (pH 6.8) and 0.3 mL of sample solution, add 0.25 mL of α-glucosidase solution, and incubate in a 37°C waterbath for 10 min. After incubation, add 0.25 mL of PNPG solution and incubate in a 37°C waterbath for 20 min. Terminate the reaction by adding 1 mL of 0.2 mol / L Na₂CO₃ solution. Measure the absorbance at 405 nm, which is recorded as A₁. The absorbances measured using water as a substitute for the sample and enzyme solution are recorded as A₁ and A₂, respectively. The α-glucosidase inhibition rate of each sample group was calculated as follows: α-glucosidase inhibition rate = 1 - (A₁ - A₂) / A₁ × 100%. Each sample was treated in triplicate, and the average value was calculated. The results are shown in Table 1.

[0044] Table 1 Inhibitory activity of different samples on α-glucosidase

[0045] sample α-glucosidase inhibition rate% EGP-3 60.4 Pycnoporus sanguineum polysaccharide extract 19.7 Pycnoporus sanguineus ethanol extract 0.92 EGP-3+Pycnoporus sanguineus polysaccharide extract 91.4 EGP-3+Pycnoporus sanguineus ethanol extract 63.5 Acarbose 93.8

[0046] The results showed that both the purified polysaccharide EGP-3 from Eucheuma truncatum and the polysaccharide extract from P. sanguineum showed inhibitory activity against α-glucosidase, but the effect was less than that of acarbose. The ethanol extract from P. sanguineum showed very weak inhibitory activity against α-glucosidase. Compared with the ethanol extract from P. sanguineum, the polysaccharide extract from P. sanguineum significantly enhanced the inhibitory activity of the purified polysaccharide EGP-3 from Eucheuma truncatum. The combined use of the polysaccharide extract from P. sanguineum and the purified polysaccharide EGP-3 from Eucheuma truncatum showed an inhibition rate on α-glucosidase close to that of acarbose. These results suggest that the combined use of the polysaccharide extract from P. sanguineum and the purified polysaccharide EGP-3 from Eucheuma truncatum can effectively inhibit the enzymatic activity of α-glucosidase, thereby effectively inhibiting the release of glucose and reducing glucose absorption in the small intestine, thereby achieving the goal of preventing type 2 diabetes.

[0047] Example 5

[0048] A health food for regulating blood sugar and blood lipids comprises, by weight, 10 parts of Eucheuma polysaccharide EGP-3, 10 parts of Pycnoporus sanguineum polysaccharide extract, 5 parts of maltodextrin, 6 parts of blueberry fruit powder and 15 parts of microcrystalline cellulose.

[0049] Preparation steps: evenly mix Eucheuma polysaccharide EGP-3, Pycnoporus sanguineum polysaccharide extract, blueberry fruit powder, maltodextrin and microcrystalline cellulose, add appropriate amount of ethanol solution to prepare soft material, granulate through 16-mesh sieve, dry at 60°C, and granulate through 12-mesh sieve to obtain the product.

[0050] Example 6

[0051] A health food for regulating blood sugar and blood lipids comprises, by weight, 15 parts of Eucheuma polysaccharide EGP-3, 15 parts of Pycnoporus sanguineum polysaccharide extract, 8 parts of maltodextrin, 8 parts of blueberry fruit powder and 20 parts of microcrystalline cellulose.

[0052] Preparation steps: evenly mix Eucheuma polysaccharide EGP-3, Pycnoporus sanguineum polysaccharide extract, blueberry fruit powder, maltodextrin and microcrystalline cellulose, add appropriate amount of ethanol solution to prepare soft material, granulate through 16-mesh sieve, dry at 60°C, and granulate through 12-mesh sieve to obtain the product.

[0053] Example 7

[0054] A health food for regulating blood sugar and blood lipids comprises, by weight, 20 parts of Eucheuma polysaccharide, 20 parts of Pycnoporus sanguineum polysaccharide extract, 10 parts of maltodextrin, 12 parts of blueberry fruit powder and 30 parts of microcrystalline cellulose.

[0055] Preparation steps: evenly mix Eucheuma polysaccharide EGP-3, Pycnoporus sanguineum polysaccharide extract, blueberry fruit powder, maltodextrin and microcrystalline cellulose, add appropriate amount of ethanol solution to prepare soft material, granulate through 16-mesh sieve, dry at 60°C, and granulate through 12-mesh sieve to obtain the product.

[0056] Example 8

[0057] A health food for regulating blood sugar and blood lipids comprises, by weight, 10 parts of Eucheuma polysaccharide EGP-3, 10 parts of Pycnoporus sanguineum ethanol extract, 5 parts of maltodextrin, 6 parts of blueberry fruit powder and 15 parts of microcrystalline cellulose.

[0058] Preparation steps: evenly mix Eucheuma polysaccharide EGP-3, Pycnoporus sanguineum ethanol extract, blueberry fruit powder, maltodextrin and microcrystalline cellulose, add appropriate amount of ethanol solution to prepare soft material, granulate through 16-mesh sieve, dry at 60°C, and granulate through 12-mesh sieve to obtain the product.

[0059] Example 9

[0060] A health food for regulating blood sugar and blood lipids comprises, by weight, 10 parts of Pycnoporus sanguineus polysaccharide extract, 5 parts of maltodextrin, 6 parts of blueberry fruit powder and 15 parts of microcrystalline cellulose.

[0061] Preparation steps: Mix the polysaccharide extract of Pycnoporus sanguineus, blueberry fruit powder, maltodextrin and microcrystalline cellulose evenly, add an appropriate amount of ethanol solution to prepare a soft material, granulate through a 16-mesh sieve, dry at 60°C, and granulate through a 12-mesh sieve to obtain the product.

[0062] Example 10

[0063] A health food for regulating blood sugar and blood lipids comprises, by weight, 10 parts of Eucheuma polysaccharide EGP-3, 5 parts of maltodextrin, 6 parts of blueberry fruit powder and 15 parts of microcrystalline cellulose.

[0064] Preparation steps: evenly mix Eucheuma polysaccharide EGP-3, blueberry fruit powder, maltodextrin and microcrystalline cellulose, add appropriate amount of ethanol solution to prepare soft material, granulate through 16-mesh sieve, dry at 60°C, and granulate through 12-mesh sieve to obtain the product.

[0065] Example 11

[0066] SPF male C57BL / 6 mice were fasted for 12 hours but not water, and 160 mg / kg of streptozotocin (STZ) solution was injected intraperitoneally. Blood was collected from the tails 3 days later to measure the fasting blood glucose (FPG) concentration of the mice. Mice with FPG ≥ 11.1 mmol / L were considered to be successful type 2 diabetes model mice.

[0067] The mice with successful modeling were randomly divided into 6 groups, namely model group, positive control group, and experimental groups 1-4. Among them, the mice in the model group were given normal saline at a dosage of 10 mL / kg, the mice in the positive control group were given 0.8 mg / kg of glibenclamide, and the mice in experimental groups 1-4 were given the health food prepared in Examples 5, 8, 9, and 10, respectively, at a dosage of 500 mg / kg. In addition, normal mice were set as blank groups, and the blank group mice were given normal saline at a dosage of 10 mL / kg. Each treatment group had 12 mice, and each group of mice was gavage-administered once a day for 4 consecutive weeks.

[0068] After 4 weeks, the blood glucose concentration, serum triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels of the mice were measured using the corresponding kits by orbital blood sampling. The results are shown in Figure 1 and Figure 2 .

[0069] Depend on Figure 1 It can be seen that compared with the blood glucose levels of mice in the model group, the health food prepared in Example 5 of the present invention and glibenclamide can significantly reduce the blood glucose levels of mice ( ### (p<0.001). As shown in Examples 8, 9, and 10, compared to the ethanol extract of P. sanguineus, the polysaccharide extract of P. sanguineus effectively enhanced the blood sugar-lowering effect of EGP-3, a polysaccharide from Eucheuma truncatum. The combined use of the polysaccharide extract of P. sanguineus and EGP-3 significantly improved blood sugar-lowering effects compared to either component alone, demonstrating a synergistic hypoglycemic effect.

[0070] Depend on Figure 2 It can be seen that compared with the blood lipid levels of the model group mice, the health food prepared in Example 5 of the present invention can effectively reduce the levels of triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in the serum of the model mice, and the effect is better than glibenclamide.

[0071] Example 12

[0072] 1. Sample solution preparation:

[0073] 1) Dissolve the purified polysaccharide EGP-3 from Eucheuma truncatum in water to prepare a solution with a concentration of 1 mg / mL;

[0074] 2) dissolving the polysaccharide extract of Pycnoporus sanguineus in water to prepare a solution with a concentration of 1 mg / mL;

[0075] 3) Dissolving the purified polysaccharide EGP-3 from Eucheuma truncatum and the polysaccharide extract from Pycnoporus sanguineus in water to prepare a solution with a concentration of 1 mg / mL for both components;

[0076] 2. 3T3-L1 cytotoxicity assay

[0077] 3T3-L1 cells were cultured at 5 × 10 4 / mL, 100μL of cells per well were inoculated into a 96-well plate and cultured for 48h; the culture medium of the 96-well plate was aspirated, 100μL of sample solution was added, and control wells and zero wells were set at the same time, and cultured for 24h; 10μL of CCK-8 staining solution was added to each well and cultured in a 37℃ incubator for 1.5h; the absorbance value was detected by a microplate reader at a wavelength of 450nm to measure the cell growth. The results showed that whether the purified polysaccharide EGP-3 of Eucheuma truncatum or the polysaccharide extract of Pycnoporus sanguinosa was used alone or in combination, the survival rate of 3T3-L1 cells was not significantly different from that of the blank group. This result shows that the components of the purified polysaccharide EGP-3 of Eucheuma truncatum and the polysaccharide extract of Pycnoporus sanguinosa of the present invention have good safety.

[0078] The above are merely preferred embodiments of the present invention. It should be noted that the above preferred embodiments should not be construed as limiting the present invention, and the scope of protection of the present invention should be determined by the scope defined in the claims. Persons skilled in the art will appreciate that improvements and modifications may be made without departing from the spirit and scope of the present invention, and such improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A health food for regulating blood sugar and blood lipids, characterized in that: The invention comprises, by weight: 10 to 20 parts of Eucheuma polysaccharide, 10 to 20 parts of Pycnoporus sanguineus extract, 5 to 10 parts of maltodextrin, 6 to 12 parts of blueberry fruit powder and 15 to 30 parts of microcrystalline cellulose.

2. The health food for regulating blood sugar and blood lipids according to claim 1, characterized in that: The Eucheuma polysaccharide is Eucheuma polysaccharide EGP-3.

3. The health food for regulating blood sugar and blood lipids according to claim 1, characterized in that: The weight average molecular weight M of the polysaccharide EGP-3 of Eucheuma truncatum w The number average molecular weight is 698KDa. n The molecular weight is 69.7 KDa and the polydispersity index is 10.

01.

4. The health food for regulating blood sugar and blood lipids according to claim 1, characterized in that: The Pycnoporus sanguineus extract is a Pycnoporus sanguineus polysaccharide extract.

5. The health food for regulating blood sugar and blood lipids according to claim 4, characterized in that: The preparation steps of the polysaccharide extract of P. sanguinii are as follows: crushing the fruiting bodies of P. sanguinii, extracting with hot water, filtering, extracting the filter residue with hot water again, filtering, combining the filtrate, concentrating the filtrate, adding ethanol to the concentrated solution for precipitation, dissolving the precipitate in water, filtering with a filter membrane, collecting the filtrate, adding ethanol to the filtrate for precipitation again, re-dissolving the collected precipitate in water, and freeze-drying to obtain the polysaccharide extract of P. sanguinii.

6. The health food for regulating blood sugar and blood lipids according to claim 5, characterized in that: The preparation steps of the polysaccharide extract of P. sanguinii are as follows: crushing the fruiting body of P. sanguinii, adding purified water at a solid-liquid ratio of 90-100 g / L, leaching at 80-90° C. for 1-2 hours, filtering, leaching the filter residue with hot water for 1-2 hours, filtering, combining the filtrate, concentrating the filtrate, adding ethanol to the concentrated solution so that the final concentration of ethanol is 70-80% by volume, standing overnight, taking the precipitate and dissolving it in water, filtering it with a 0.22 μm filter membrane, collecting the filtrate, adding ethanol to the filtrate for precipitation again, collecting the precipitate and re-dissolving it with water, and freeze-drying to obtain the polysaccharide extract of P. sanguinii.

7. A method for preparing the health food for regulating blood sugar and blood lipids according to any one of claims 1 to 6, characterized in that: The following steps are involved: Eucheuma polysaccharide, Pycnoporus sanguineus extract, blueberry fruit powder, maltodextrin and microcrystalline cellulose are uniformly mixed, and a proper amount of ethanol solution is added to prepare a soft material, which is sieved for granulation, dried, and sieved for whole granules to obtain the product.

8. The preparation method according to claim 7, characterized in that: The sieving granulation is through a 16-mesh sieve, and the sieving whole granulation is through a 12-mesh sieve.

9. The preparation method according to claim 7, characterized in that: The drying is carried out at 60°C.

10. Use of the health food for regulating blood sugar and blood lipids according to any one of claims 1 to 6 in lowering blood sugar and blood lipids.

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