Composition for oral care of dogs and cats, oral care cream and preparation method of oral care cream

Abstract

The invention discloses an oral care composition for dogs and cats, oral care cream and a preparation method of the oral care cream. The oral care composition for dogs and cats is prepared from the following raw materials: lactoferrin, nano zinc oxide, lysozyme, glucose oxidase, xylooligosaccharide, water-soluble sodium ascorbate phosphate, an inactivated lactobacillus fermentation product, sodium humate, sodium copper chlorophyllin, catnip, yucca, tea polyphenol, glycine and resistant dextrin. The components act together, the whole pet oral care solution is suitable for pet oral care, efficacy tests prove that the pet oral care solution can effectively promote oral health of pet dogs and cats, and the comprehensive effect of pet oral care is achieved. The oral care composition with a scientific formula is properly added, so that the oral saliva colonies of dogs and cats can be inhibited, the content of hydrogen sulfide in the oral cavities of pet dogs and cats can be reduced, the halitosis of pets can be quickly relieved, and fresh breath can be maintained; the palatability is good, the acceptability of pets is high, and the oral disease risk of dogs and cats can be reduced.

Description

Technical Field

[0001] The invention belongs to the technical field of pet breeding, and in particular relates to a composition for oral care of dogs and cats, an oral care cream and a preparation method thereof. Background Art

[0002] With the popularity of pet keeping, the oral health of pets has received increasing attention. Oral health has an important impact on the overall health of pets. Oral problems may cause bad breath, yellow teeth, red and swollen gums, etc., affecting the appearance of pets and the interaction with pet owners. It may also cause oral pain and gingivitis in pets, affecting the appetite and digestion of pets. If oral cleaning is not performed for a long time, tartar will form on the pet's teeth, causing periodontal disease. In severe cases, it will lead to gum atrophy, tooth loss, and even other diseases such as heart disease and diabetes.

[0003] Traditional oral care products, such as pet toothpaste, oral spray, mouthwash, etc., are often difficult to implement effectively due to the low degree of pet cooperation; there are also some pet snacks such as tooth cleaning bones and tooth cleaning sticks. If the product tastes bad, pets will refuse to use it or have resistance, which will also affect the maintenance of their oral health. Secondly, some products are too focused on efficacy, with too many chemical additives or the use of drugs, such as adding fluoride, foaming agents, chlorhexidine and other ingredients commonly used in human oral care products, which may pose potential risks to the health of pets after swallowing. In addition, the effects of some products are short-lived after use, and may not have undergone sufficient clinical trials and verification. They cannot keep the pet's oral cavity clean and healthy for a long time, and their effectiveness and safety cannot be fully guaranteed. Summary of the invention

[0004] In order to solve one or more of the above problems, the present invention provides a composition for oral care of dogs and cats, an oral care cream and a preparation method thereof.

[0005] According to one aspect of the present application, a dog and cat oral care composition is composed of the following raw materials in weight proportions: 1-5 parts of lactoferrin, 0.1-0.5 parts of nano zinc oxide, 3-12 parts of lysozyme, 2-8 parts of glucose oxidase, 4-8 parts of xylo-oligosaccharides, 20-40 parts of water-soluble sodium ascorbyl phosphate, 2-4 parts of inactivated lactic acid bacteria fermentation product, 1-3 parts of sodium humate, 0.2-1 parts of sodium copper chlorophyll, 10-20 parts of catnip, 0.2-0.5 parts of yucca, 0.1-0.2 parts of tea polyphenols, 5-10 parts of glycine, and 60-100 parts of resistant dextrin.

[0006] Among the above-mentioned added components, the beneficial effects are:

[0007] Lactoferrin has antibacterial and anti-inflammatory properties that can help reduce harmful bacteria in the mouth while promoting oral health.

[0008] Nano zinc oxide has excellent antibacterial properties, which can further inhibit the growth of oral bacteria. Lysozyme is able to break down bacterial cell walls, thereby reducing the number of bacteria and helping to control the microbial balance in the mouth.

[0009] Glucose oxidase can consume sugar in the mouth, reduce the chance of bacteria producing acid, and reduce the risk of tooth decay.

[0010] As prebiotics, xylooligosaccharides and resistant dextrins can regulate intestinal flora, promote the absorption of minerals such as calcium and phosphorus, help strengthen teeth and prevent gum disease.

[0011] Water-soluble sodium ascorbyl phosphate provides a highly soluble and stable form of vitamin C that limits the survival and growth of harmful oral bacteria, chelates calcium ions to reduce plaque and tartar formation, and helps enhance gum health and improve the body's antioxidant status.

[0012] The fermentation products of inactivated lactic acid bacteria can inhibit periodontal pathogens and freshen breath. Sodium humate has antibacterial, anti-inflammatory and oral mucosal repair effects.

[0013] Sodium copper chlorophyllin has antibacterial and anti-inflammatory properties and helps reduce the formation of dental plaque.

[0014] Catnip contains natural ingredients that can help clean teeth and gums, while having a soothing effect and providing a specific taste and flavor to increase the comfort and pleasure of pets when using it and improve palatability.

[0015] Glycine helps neutralize the acidic environment in your mouth, reducing erosion and decreasing bacterial growth.

[0016] Yucca and tea polyphenols have good anti-inflammatory and antioxidant properties and significant free radical scavenging capabilities, which can effectively relieve oral inflammation, eliminate odor, and reduce bad breath problems in pets.

[0017] The role and safety of each component of the above-mentioned oral care composition in oral care are important factors in determining its dosage. For example, components such as lactoferrin and lysozyme have antibacterial effects, and their dosage needs to be sufficient to exert their effects, but not excessive to avoid causing side effects. Secondly, some ingredients may be unstable in water or finished products, for example, sodium copper chlorophyllin and tea polyphenols, and the dosage needs to be adjusted according to their solubility and stability. Finally, oral care products need to meet specific formulation requirements to ensure their overall effect. For example, components such as oligoxylose and resistant dextrin are used as prebiotics, and appropriate addition can regulate intestinal flora, but excessive use may cause soft stools and diarrhea, and too little will have no effect.

[0018] These components work together through multiple mechanisms such as antibacterial, anti-inflammatory, antioxidant, cleansing, and promoting oral microecological balance. The addition of catnip to improve palatability makes them suitable for pet oral care as a whole. Efficacy tests have proven that they can effectively promote the oral health of pet dogs and cats and achieve the comprehensive effect of pet oral care.

[0019] According to another aspect of the present application, a method for preparing the aforementioned oral care composition for dogs and cats is provided, comprising the following steps:

[0020] S1. Pass all raw materials through a 60-mesh sieve;

[0021] S2. Weigh the raw materials in parts by weight respectively;

[0022] S3. Mix the weighed raw materials;

[0023] S4. The mixed raw materials are granulated;

[0024] S5. Discharging.

[0025] The beneficial effects are: the entire preparation process of the oral care composition for dogs and cats ensures optimal product performance and stability and is simple and easy to implement.

[0026] In some embodiments, the method comprises the following steps: the glycine is first crushed and then passed through a 60-mesh screen. The beneficial effect is that the glycine is first crushed and then passed through a 60-mesh screen to facilitate the subsequent mixing of various materials.

[0027] In some embodiments, the following steps are included: the mixing in step S3 is carried out in a high-efficiency wet granulator, the rotation speed during the mixing is 80 rpm; the mixing time is 5 minutes; the rotation speed during the granulation is 1200 rpm; and the time is 5 minutes.

[0028] In some embodiments, the following steps are included: the granulation in step S4 is carried out in a high-efficiency wet granulator, the rotation speed during the mixing is 125 rpm; the mixing time is 5 minutes; the rotation speed during the granulation is 2500 rpm; and the time is 5 minutes.

[0029] The beneficial effect is that each material can be evenly mixed after multiple mixing and shearing by the stirring paddle and the cutting knife in a short time, thus ensuring the uniformity of the functional components. At the same time, the high-speed rotating knife disc generates high shear force, and the material is formed into dense and uniform particles through shearing and compression, without the need for additional adhesives and drying treatment, which is efficient, energy-saving, and environmentally friendly, and can shorten the granulation time and improve production efficiency.

[0030] According to another aspect of the present application, there is provided a use of the aforementioned oral care composition for dogs and cats in preparing oral care products for dogs and cats.

[0031] According to another aspect of the present application, a dog and cat oral care cream is provided, comprising the dog and cat oral care composition as claimed in claim 1.

[0032] In some embodiments, the composition for oral care of dogs and cats is 50-150 parts;

[0033] 200-500 parts of purified water, 100-200 parts of glycerol, 100-300 parts of hydrated silica, 50-150 parts of calcium hydrogen phosphate, 10-50 parts of cellulose, 5-30 parts of xanthan gum, 10-50 parts of flavor enhancer and 2-10 parts of vitamin B complex premix.

[0034] Its beneficial effects are: among the above-mentioned added components, glycerol as a wetting agent helps to maintain the moist state of the paste, while providing a certain sweetness, increasing the acceptance of pets when using it. Hydrated silica and calcium hydrogen phosphate as abrasives can increase the cleaning effect, help remove tartar and clean teeth. Cellulose and xanthan gum as thickeners keep the paste texture stable, which is convenient for pets to lick and use. Taste enhancers improve the taste and acceptance, making pets more willing to use it. Vitamin B premix as a nutritional supplement contributes to the health of the oral mucosa and promotes the repair and regeneration of oral tissues. The oral care composition contains ingredients such as lactoferrin, nano zinc oxide, lysozyme, etc., which have anti-inflammatory, antibacterial, antiviral, fresh breath and other biocatalytic functions, which can further maintain oral health. Combining the above components, the pet oral care paste achieves the purpose of cleaning teeth, maintaining oral health and preventing oral diseases through the synergistic effects of physical cleaning, chemical action, biological activity and nutritional supplementation.

[0035] The role and safety of each ingredient in oral care paste in oral care are important factors in determining its dosage. For example, hydrated silica and calcium hydrogen phosphate as abrasives can increase the cleaning effect, help remove tartar and clean teeth. Their dosage needs to be sufficient to exert their effectiveness, but not excessive to avoid side effects. Secondly, some B vitamins are unstable in water, so the dosage needs to be adjusted according to their solubility and stability. Finally, oral care pastes need to meet specific formulation requirements to ensure their overall effectiveness. For example, cellulose and xanthan gum are used as thickeners. The appropriate amount can keep the texture of the paste stable and facilitate pets to lick and use, but too little or too much will cause the paste to be unstable, which is inconvenient to produce and use.

[0036] This application improves the overall quality and effect of pet oral care cream by optimizing raw material selection and ratio, innovating production processes, enhancing functional ingredients, and improving taste and palatability.

[0037] Using oral care paste is a relatively painless and non-invasive method, especially suitable for pets who are resistant to brushing their teeth. Compared with conventional solid snacks, the paste stays in the pet's mouth for a longer time, allowing the active ingredients to fully exert their effects. The method of use is simple, making it easier for pet owners to adhere to regular oral care for their pets. It also has good palatability and can be fed directly, which is highly accepted by pets; it can improve the overall oral health of pets and reduce the risk of oral diseases.

[0038] According to the physiological characteristics of dogs and cats, a paste dosage form that is easy to feed is used, and a scientifically formulated oral care composition is added in an appropriate amount, which can inhibit the saliva colony in the oral cavity of dogs and cats, reduce hydrogen sulfide in the oral cavity of pet dogs and cats, quickly relieve pet bad breath, and maintain fresh breath; it has good palatability and is highly accepted by pets; it is easy to use and can be fed directly, or applied to the surface of pet teeth or used in combination with a special pet toothbrush; it can improve the overall oral health of pets and reduce the risk of oral diseases.

[0039] According to another aspect of the present application, a method for preparing the aforementioned oral care cream for dogs and cats is provided, characterized in that it comprises the following steps:

[0040] S1. Weigh all raw materials by weight;

[0041] S2. The purified water, glycerin and xanthan gum weighed are first added into a vacuum emulsification tank and homogenized and stirred to obtain a first mixture;

[0042] S3. After adding hydrated silica, calcium hydrogen phosphate, cellulose, taste enhancer, vitamin B premix and oral care composition to the first mixture, the vacuum system and the water cooling system are turned on;

[0043] S4. Start homogenizing and stirring to prepare the oral care cream.

[0044] The beneficial effect is that the basic materials such as purified water, glycerin and xanthan gum are first homogenized and stirred to obtain a liquid first mixture, which can be used as a basis for dissolution and dispersion. Then, the functional component materials are added thereto and continued to be homogenized and stirred to obtain an oral care paste. Following this sequence can ensure that the materials are mixed evenly and improve the quality and stability of the paste product.

[0045] In some embodiments, the homogenizing stirring in step S2 is set to a homogenizing rate of 3000 r / min, a stirring rate of 40 r / min, and a stirring time of 2 min.

[0046] In some embodiments, the homogenizing stirring in step S3 is set to a homogenizing rate of 2000 r / min, a stirring rate of 40 r / min, and a stirring time of 30 min.

[0047] The beneficial effects are as follows: in the preparation method of the present application, high-speed homogenization can quickly break up the materials, improve the mixing uniformity, ensure sufficient contact and reaction between the materials, help refine the particles, and make the final product more delicate and taste better. A lower stirring rate helps to evenly distribute the materials in the tank, avoid local overheating or excessive shearing, and reduce the formation of foam, avoiding the impact of excessive foam on product quality.

[0048] Turning on the vacuum system helps remove bubbles during the mixing process to ensure uniform product texture. Turning on the water cooling system helps prevent heat-sensitive materials such as lactoferrin and lysozyme from denaturing and decomposing during the mixing process to maintain product stability.

[0049] Appropriate vacuum degree helps to improve the mixing effect, so that the materials are fully mixed in the tank, and the materials have less contact with air, which helps to prevent oxidation and maintain product stability.

[0050] These parameter settings thus help improve mixing efficiency, ensure product quality, maintain product stability, and ensure that the final product has a good taste and texture.

[0051] It can effectively inhibit the saliva colonies in the oral cavity of dogs and cats, reduce the hydrogen sulfide in the oral cavity of pet dogs and cats, and can quickly relieve the bad breath of pets and maintain fresh breath. BRIEF DESCRIPTION OF THE DRAWINGS

[0052] Figure 1 This is a comparison of the natural light sensory perception of the teeth of dogs and cats in the control group;

[0053] Figure 2 This is a comparison chart of the natural light sensory perception of dog and cat teeth in Example Group 1;

[0054] Figure 3 This is a natural light sensory comparison diagram of dog and cat teeth in Example Group 2;

[0055] Figure 4 This is a comparison chart of the natural light sensory perception of dog and cat teeth in Example Group 3;

[0056] Figure 5 This is a natural light sensory comparison diagram of dog and cat teeth in Example Group 4;

[0057] Figure 6 This is a natural light sensory comparison diagram of dog and cat teeth in Example Group 5;

[0058] Figure 7 This is a comparison chart of the natural light sensory perception of dog and cat teeth in Example Group 6. DETAILED DESCRIPTION

[0059] (I) Implementation Examples

[0060] Preparation of oral care composition:

[0061] Embodiment 1:

[0062] S1. All raw materials are sieved through a 60-mesh sieve; glycine is first crushed and then sieved through a 60-mesh sieve;

[0063] S2. Weigh the raw materials according to weight:

[0064] 5 parts of lactoferrin, 0.1 parts of nano zinc oxide, 12 parts of lysozyme, 8 parts of glucose oxidase, 4 parts of xylo-oligosaccharides, 20 parts of water-soluble sodium ascorbyl phosphate, 4 parts of inactivated lactic acid bacteria fermentation products, 1 part of sodium humate, 1 part of sodium copper chlorophyll, 20 parts of catnip, 0.5 parts of yucca, 0.2 parts of tea polyphenols, 10 parts of glycine, and 60 parts of resistant dextrin.

[0065] S3. The weighed raw materials were put into a high-efficiency wet granulator for low-speed stirring: 80 rpm; low-speed granulation: 1200 rpm; mixing time: 5 minutes.

[0066] S4. The above mixed raw materials were put into an efficient wet granulator for high-speed stirring: 120 rpm; high-speed granulation: 2500 rpm; mixing time: 5 minutes to obtain an oral care composition A.

[0067] Embodiment 2:

[0068] S1. All raw materials are sieved through a 60-mesh sieve; glycine is first crushed and then sieved through a 60-mesh sieve;

[0069] S2. Weigh the raw materials according to weight:

[0070] 1 part of lactoferrin, 0.5 parts of nano zinc oxide, 3 parts of lysozyme, 2 parts of glucose oxidase, 8 parts of xylo-oligosaccharides, 40 parts of water-soluble sodium ascorbyl phosphate, 2 parts of inactivated lactic acid bacteria fermentation product, 3 parts of sodium humate, 0.2 parts of sodium copper chlorophyll, 10 parts of catnip, 0.2 parts of yucca, 0.1 parts of tea polyphenols, 5 parts of glycine, and 100 parts of resistant dextrin.

[0071] S3. The weighed raw materials were put into a high-efficiency wet granulator for low-speed stirring: 80 rpm; low-speed granulation: 1200 rpm; mixing time: 5 minutes.

[0072] S4. The above mixed raw materials were put into an efficient wet granulator for high-speed stirring: 120 rpm; high-speed granulation: 2500 rpm; mixing time: 5 minutes, to obtain an oral care composition B.

[0073] Embodiment 3:

[0074] S1. All raw materials are sieved through a 60-mesh sieve; glycine is first crushed and then sieved through a 60-mesh sieve;

[0075] S2. Weigh the raw materials according to weight:

[0076] 3 parts of lactoferrin, 0.3 parts of nano zinc oxide, 8 parts of lysozyme, 5 parts of glucose oxidase, 6 parts of xylo-oligosaccharides, 30 parts of water-soluble sodium ascorbyl phosphate, 3 parts of inactivated lactic acid bacteria fermentation product, 2 parts of sodium humate, 0.6 parts of sodium copper chlorophyll, 15 parts of catnip, 0.35 parts of yucca, 0.15 parts of tea polyphenols, 7 parts of glycine, and 80 parts of resistant dextrin.

[0077] S3. The weighed raw materials were put into a high-efficiency wet granulator for low-speed stirring: 125 rpm; low-speed granulation: 2500 rpm; mixing time: 5 minutes.

[0078] S4. The above mixed raw materials were put into an efficient wet granulator for high-speed stirring: 120 rpm; high-speed granulation: 2500 rpm; mixing time: 5 minutes, to obtain an oral care composition C.

[0079] Preparation of oral care paste:

[0080] Embodiment 4:

[0081] S1. Weigh all raw materials by weight:

[0082] 200 parts of purified water, 200 parts of glycerin, 300 parts of hydrated silica, 150 parts of calcium hydrogen phosphate, 10 parts of cellulose, 5 parts of xanthan gum, 50 parts of taste enhancer, 10 parts of vitamin B complex premix and 150 parts of oral care composition A.

[0083] The vitamin B complex premix includes vitamin B1 13000 mg / kg, vitamin B2 16000 mg / kg, vitamin B6 10000 mg / kg, niacin 80000 mg / kg, and pantothenic acid 60000 mg / kg.

[0084] S2. The purified water, glycerin and xanthan gum weighed were first added into the vacuum emulsification tank, homogenization stirring was started, the homogenization rate was set to 3000r / min, the stirring rate was 40r / min, and the first mixture was obtained after stirring for 2min;

[0085] S3. After adding hydrated silica, calcium hydrogen phosphate, cellulose, flavor enhancer, vitamin B group premix and oral care composition A to the first mixture, the vacuum system and the water cooling system are turned on; the temperature in the tank is maintained below 30°C, and the vacuum degree is maintained at 0.05 MPa to 0.06 MPa.

[0086] S4. Start homogenization and stirring to obtain oral care cream. Specifically, set the homogenization rate to 2000 r / min and the stirring rate to 40 r / min; stir for 30 minutes to obtain oral care cream A.

[0087] Embodiment 5:

[0088] S1. Weigh all raw materials by weight:

[0089] 500 parts of purified water, 100 parts of glycerol, 100 parts of hydrated silica, 50 parts of calcium hydrogen phosphate, 50 parts of cellulose, 30 parts of xanthan gum, 10 parts of taste enhancer, 2 parts of vitamin B complex premix and 50 parts of oral care composition B.

[0090] The vitamin B complex premix includes vitamin B1 13000 mg / kg, vitamin B2 16000 mg / kg, vitamin B6 10000 mg / kg, niacin 80000 mg / kg, and pantothenic acid 60000 mg / kg.

[0091] S2. The purified water, glycerin and xanthan gum weighed were first added into the vacuum emulsification tank, homogenization stirring was started, the homogenization rate was set to 3000r / min, the stirring rate was 40r / min, and the first mixture was obtained after stirring for 2min;

[0092] S3. After adding hydrated silica, calcium hydrogen phosphate, cellulose, flavor enhancer, vitamin B group premix and oral care composition B to the first mixture, the vacuum system and the water cooling system are turned on; the temperature in the tank is maintained below 30°C, and the vacuum degree is maintained at 0.05 MPa to 0.06 MPa.

[0093] S4. Start homogenization and stirring to obtain oral care cream. Specifically, set the homogenization rate to 2000 r / min and the stirring rate to 40 r / min; stir for 30 minutes to obtain oral care cream B.

[0094] Embodiment 6:

[0095] S1. Weigh all raw materials by weight:

[0096] 350 parts of purified water, 150 parts of glycerin, 200 parts of hydrated silica, 100 parts of calcium hydrogen phosphate, 30 parts of cellulose, 18 parts of xanthan gum, 30 parts of taste enhancer, 5 parts of vitamin B complex premix and 100 parts of oral care composition C.

[0097] The vitamin B complex premix includes vitamin B1 13000 mg / kg, vitamin B2 16000 mg / kg, vitamin B6 10000 mg / kg, niacin 80000 mg / kg, and pantothenic acid 60000 mg / kg.

[0098] S2. The purified water, glycerin and xanthan gum weighed were first added into the vacuum emulsification tank, homogenization stirring was started, the homogenization rate was set to 3000r / min, the stirring rate was 40r / min, and the first mixture was obtained after stirring for 2min;

[0099] S3. After adding hydrated silica, calcium hydrogen phosphate, cellulose, flavor enhancer, vitamin B group premix and oral care composition C to the first mixture, the vacuum system and the water cooling system are turned on; the temperature in the tank is maintained below 30°C, and the vacuum degree is maintained at 0.05 MPa to 0.06 MPa.

[0100] S4. Start homogenization and stirring to obtain oral care cream. Specifically, set the homogenization rate to 2000 r / min and the stirring rate to 40 r / min; stir for 30 minutes to obtain oral care cream C.

[0101] (II) Comparative Examples

[0102] Thirty-five adult dogs and cats aged over one year old were selected and randomly divided into seven groups, 5 in each group, including a dog control group, a dog embodiment group 1, a dog embodiment group 2, a dog embodiment group 3, a dog embodiment group 4, a dog embodiment group 5, and a dog embodiment group 6, and seven groups, including a cat control group, a cat embodiment group 1, a cat embodiment group 2, a cat embodiment group 3, a cat embodiment group 4, a cat embodiment group 5, and a cat embodiment group 6.

[0103] Control group: The control group fed with regular diet and daily drinking water;

[0104] Example Group 1: feeding the diet supplemented with the oral care composition A of Example 1 and daily drinking water;

[0105] Example Group 2: feeding the diet supplemented with the oral care composition B of Example 2 and daily drinking water;

[0106] Example Group 3: feeding the diet supplemented with the oral care composition C of Example 3 and daily drinking water;

[0107] Example Group 4: fed with conventional diet, daily drinking water and Example 4 oral care paste A.

[0108] Example Group 5: fed with conventional diet, daily drinking water and Example 5 oral care paste B.

[0109] Example Group 6: fed with conventional diet, daily drinking water and oral care paste C of Example 3.

[0110] The experimental period was 14 days. The mice were housed in separate cages and had free access to food and water.

[0111] (III) Determination of oral care effectiveness:

[0112] During the formal phase, the following examinations were performed on the experimental dogs and cats at fixed times on the 0th, 7th and 14th days of the experiment:

[0113] (1) Determination of oral hydrogen sulfide content

[0114] Use a gas tester to test the hydrogen sulfide content in the mouths of dogs and cats, calculated in ppm.

[0115] (2) Determination of oral flora

[0116] The oral saliva of all the dogs and cats was collected and tested, and the bacterial colony count was determined by referring to the plate counting method.

[0117] (3) Determination of product acceptance:

[0118] 20 healthy adult cats and 20 adult dogs were selected for product acceptance test. 2g of each of the oral care composition A, oral care composition B, oral care composition C, oral care cream A, oral care cream B and oral care cream C were weighed, and the reactions of the test cats and test dogs were observed and evaluated within 1 hour to determine the product acceptance of the test cats and test dogs (feeding amount*100% / feeding amount). Feed continuously for 2 days, observe and record the data.

[0119] (IV) Effect and results section:

[0120] Data processing: SPSS11.0 was used for statistical analysis.

[0121] Table 1 - Oral Hydrogen Sulfide Concentrations in Cats

[0122]

[0123] Table 2 - Oral Hydrogen Sulfide Concentrations in Dogs

[0124]

[0125]

[0126] Table 3- Total number of colonies in cat oral saliva

[0127]

[0128] Table 4 - Total colony counts in dog oral saliva

[0129]

[0130]

[0131] As shown in Table 1, on the 7th day, the oral hydrogen sulfide concentrations of cats in Example Group 1 and Group 2 were significantly lower than those in the control group (P < 0.05), and the oral hydrogen sulfide concentrations of cats in Example Group 3, Group 4, Group 5, and Group 6 were extremely significantly lower than those in the control group (P < 0.01); on the 14th day, the oral hydrogen sulfide concentrations of cats in Example Group 1, Group 2, Group 3, Group 4, Group 5, and Group 6 were extremely significantly lower than those in the control group (P < 0.01), indicating that the oral care composition and oral care cream can effectively reduce the hydrogen sulfide concentration in the cat's mouth in as fast as 7 days.

[0132] As shown in Table 2, on the 7th day, the oral hydrogen sulfide concentration of the dogs in Example Group 1, Group 2, Group 3, and Group 5 was significantly lower than that in the control group (P < 0.01), and the oral hydrogen sulfide concentration of the dogs in Example Group 4 and Group 6 was significantly lower than that in the control group (P < 0.01); on the 14th day, the oral hydrogen sulfide concentration of the dogs in Example Group 1, Group 2, Group 3, Group 4, Group 5, and Group 6 was significantly lower than that in the control group (P < 0.01); this indicates that the oral care composition and the oral care cream can effectively reduce the hydrogen sulfide concentration in the oral cavity of dogs in as fast as 7 days.

[0133] As shown in Table 3, on the 7th day, the saliva colonies of cats in Example Group 3, Group 4, Group 5 and Group 6 were significantly reduced (P < 0.05); on the 14th day, the saliva colonies of cats in Example Group 1 and Group 2 were significantly reduced (P < 0.05), and the saliva colonies of cats in Group 3, Group 4, Group 5 and Group 6 were extremely significantly reduced (P < 0.01), indicating that the oral care composition can effectively reduce the total number of colonies in the cat's mouth for 14 days, and the oral care cream can effectively reduce the total number of colonies in the cat's mouth in as fast as 7 days.

[0134] As shown in Table 4, on the 7th day, the saliva colony counts of the dogs in Example Group 3 and Group 4 were significantly reduced (P < 0.05), and the saliva colony counts of the dogs in Example Group 5 and Group 6 were extremely significantly reduced (P < 0.01); on the 14th day, the saliva colony counts of the dogs in Example Group 1 and Group 2 were significantly reduced (P < 0.05), and the saliva colony counts of the dogs in Example Group 3, Group 4, Group 5, and Group 6 were extremely significantly reduced (P < 0.01). This indicates that the oral care composition and oral care cream can effectively reduce the total colony count in the dog's oral cavity for 14 days.

[0135] Table 5 Pet product acceptance

[0136]

[0137] From the data in Table 5, it can be seen that the product acceptance of cats in the embodiment group is above 85%, and the acceptance of dogs is above 90%, which shows that the product has good palatability and good acceptance by pets.

[0138] In addition, by observing the dental conditions of canines, cat teeth and molars of each group of dogs and cats under natural light, the following Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 As shown, there was no significant change in the sensory perception of dental plaque and calculus in the control group, while there was a significant improvement trend in the sensory perception of dental plaque and calculus in the oral cavity of the dogs and cats in the example.

[0139] In summary, compared with the control group, the products prepared in the embodiment group can effectively inhibit the saliva colonies in the oral cavity of dogs and cats, reduce hydrogen sulfide in the oral cavity of pet dogs and cats, quickly relieve the bad breath of pets, and maintain fresh breath. The product has good palatability and can be fed directly. It is suitable for pet oral care as a whole, and the efficacy test proves that it can effectively promote the oral health of pet dogs and cats, and achieve the comprehensive effect of pet oral care.

[0140] The above is only a preferred embodiment of the present invention and is not intended to limit the present invention. It should be pointed out that for ordinary technicians in this field, other modifications and improvements can be made without departing from the creative concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A dog and cat oral care composition, characterized in that: The invention is composed of the following raw materials in parts by weight: 1-5 parts of lactoferrin, 0.1-0.5 parts of nano zinc oxide, 3-12 parts of lysozyme, 2-8 parts of glucose oxidase, 4-8 parts of xylo-oligosaccharide, 20-40 parts of water-soluble sodium ascorbyl phosphate, 2-4 parts of inactivated lactic acid bacteria fermentation product, 1-3 parts of sodium humate, 0.2-1 parts of sodium copper chlorophyll, 10-20 parts of catnip, 0.2-0.5 parts of yucca, 0.1-0.2 parts of tea polyphenols, 5-10 parts of glycine and 60-100 parts of resistant dextrin.

2. A method for preparing the oral care composition for dogs and cats according to claim 1, characterized in that: The following steps are involved: S1. Pass all raw materials through a 60-mesh sieve; S2. Weigh the raw materials in parts by weight respectively; S3. Mix the weighed raw materials; S4. The mixed raw materials are granulated; S5. Discharging.

3. The method for preparing a composition for oral care of dogs and cats according to claim 2, characterized in that: The following steps are involved: The glycine is first crushed and then passed through a 60-mesh sieve.

4. The method for preparing a composition for oral care of dogs and cats according to claim 2, characterized in that: The following steps are involved: The mixing in step S3 is carried out in a high-efficiency wet granulator. During the mixing, the stirring blade speed is 80 rpm; the mixing time is 5 minutes; During the granulation, the cutting knife rotates at a speed of 1200 rpm and the granulation time is 5 minutes.

5. The method for preparing a composition for oral care of dogs and cats according to claim 2, characterized in that: The following steps are involved: The granulation in step S4 is carried out in a high-efficiency wet granulator. During the mixing, the stirring blade speed is 125 rpm; the mixing time is 5 minutes; The cutting blade rotation speed during the granulation is 2500 rpm; the granulation time is 5 minutes.

6. Use of the dog and cat oral care composition according to claim 1 in preparing dog and cat oral care products.

7. An oral care cream for dogs and cats, characterized in that: The invention comprises the oral care composition for dogs and cats according to claim 1.

8. A dog and cat oral care cream according to claim 7, characterized in that: 50-150 parts of the oral care composition for dogs and cats; and 200-500 parts of purified water, 100-200 parts of glycerol, 100-300 parts of hydrated silica, 50-150 parts of calcium hydrogen phosphate, 10-50 parts of cellulose, 5-30 parts of xanthan gum, 10-50 parts of flavor enhancer and 2-10 parts of vitamin B complex premix.

9. The method for preparing the dog and cat oral care paste according to claim 8, characterized in that: The following steps are involved: S1. Weigh all raw materials by weight; S2. The purified water, glycerin and xanthan gum weighed are first added into a vacuum emulsification tank and homogenized and stirred to obtain a first mixture; S3. After adding hydrated silica, calcium hydrogen phosphate, cellulose, taste enhancer, vitamin B premix and oral care composition to the first mixture, the vacuum system and the water cooling system are turned on; S4. Start homogenizing and stirring to prepare the oral care cream.

10. The method according to claim 9, characterized in that The homogenizing stirring in step S2 was set at a homogenizing rate of 3000 r / min, a stirring rate of 40 r / min, and a stirring time of 2 min.

11. The method according to claim 10, characterized in that The homogenization stirring in step S3 was set at a homogenization rate of 2000 r / min, a stirring rate of 40 r / min, and a stirring time of 30 min.

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