Medicinal liquor for conditioning gout and preparation method thereof

Abstract

The invention discloses medicinal liquor for conditioning gout and a preparation method thereof. The medicinal liquor for conditioning gout is prepared from the following raw materials in parts by weight: 15-25 parts of sika deer sinew, 5-15 parts of safflower, 15-25 parts of cuttlebone, 1-10 parts of scorpion, 5-15 parts of eucommia ulmoides, 25-35 parts of astragalus membranaceus, 10-20 parts of cudrania cochinchinensis, 10-20 parts of radix paeoniae alba, 10-20 parts of red dates, 10-20 parts of poria cocos, 10-20 parts of platycodon grandiflorum, 15-25 parts of pseudo-ginseng, 15-25 parts of lucid ganoderma, 10-20 parts of oroxylum indicum, 15-25 parts of cassia twig and 700-1000 parts of grain liquor. Through scientific proportioning, the traditional Chinese medicine composition can well achieve the effects of reducing uric acid, promoting blood circulation to remove meridian obstruction, clearing damp and dissipating blood stasis, diminishing inflammation and easing pain, promoting digestion of spleen and stomach functions, improving liver and kidney functions, improving immunity, nourishing, regulating qi and the like, so that the traditional Chinese medicine composition has good improving and conditioning effects on gout, waist soreness, back pain and the like, and also has good effects of improving immunity and tonifying qi.

Description

Technical Field

[0001] The invention belongs to the technical field of medicinal wines, and specifically relates to a medicinal wine for regulating gout and a preparation method thereof. Background Art

[0002] Gout is a group of diseases caused by long-term purine metabolism disorders and increased blood uric acid, which leads to tissue damage. It is also called "hyperuricemia" and is a type of arthritis, also known as metabolic arthritis. Gout has obvious heterogeneity in onset. In addition to hyperuricemia, it can manifest as acute arthritis, tophi, chronic arthritis, joint deformities, chronic interstitial nephritis and uric acid urinary stones. The clinical manifestations of gout patients are obvious redness, swelling, heat and pain in the affected joints. The attacks often occur at night, and the patients wake up due to severe joint pain. The joints cannot be touched due to pain, and they cannot even be covered with sheets. The movement is limited and the patients suffer a lot. At present, gout is mainly treated with Western medicine, such as colchicine, nonsteroidal anti-inflammatory analgesics, adrenal glucocorticoids and probenecid. Although these Western medicines are effective quickly, they are mostly only for the purpose of relieving pain, and it is difficult to achieve the purpose of radical cure. The pain is easy to relapse after stopping the drug, and these drugs often have large toxic side effects. In addition to causing gastrointestinal reactions, long-term use may also lead to bone marrow suppression, liver cell damage, mental depression, ascending paralysis, respiratory depression, etc. For the traditional Chinese medicine treatment of gout, there are Simiao Yong'an Decoction, Qubi Decoction, Shentong Zhuyu Decoction, Qingre Lishi Chubi Recipe, etc. Most of them are ancient Chinese medicine prescriptions. Although they have certain efficacy, the decoction process of Chinese medicine soup is complicated, the effect is slow, the course of treatment is long, and the efficacy is not obvious for some patients. Summary of the invention

[0003] In order to solve the problems raised in the above background technology, the purpose of the present invention is to provide a medicinal wine for regulating gout and a preparation method thereof. The medicinal wine can be used to prevent and regulate gout, has significant therapeutic effects, can effectively avoid recurrence, and has no toxic side effects. It breaks through the defect that most of the effective components of traditional Chinese medicine in conventional technology cannot be released, and the animal raw materials and plant raw materials are extracted and processed separately, so that the respective medicinal effects can be fully exerted.

[0004] In order to solve the above technical problems, the technical solution provided by the present invention is: A medicinal wine for regulating gout is composed of the following raw materials in parts by weight: 15-25 parts of sika deer tendons, 5-15 parts of safflower, 15-25 parts of cuttlebone, 1-10 parts of scorpion, 5-15 parts of eucommia bark, 25-35 parts of astragalus, 10-20 parts of radix scutellariae, 10-20 parts of white peony root, 10-20 parts of red dates, 10-20 parts of tuckahoe, 10-20 parts of platycodon, 15-20 parts of notoginseng, 15-25 parts of ganoderma lucidum, 10-20 parts of melaleuca, 15-25 parts of cassia twig, and 700-1000 parts of grain liquor.

[0005] Furthermore, it is composed of the following raw materials in parts by weight: 20 parts of sika deer tendons, 10 parts of safflower, 20 parts of cuttlebone, 5 parts of scorpion, 10 parts of eucommia, 30 parts of astragalus, 15 parts of radix scutellariae, 15 parts of white peony, 15 parts of red dates, 15 parts of poria, 15 parts of platycodon, 20 parts of panax notoginseng, 20 parts of ganoderma lucidum, 15 parts of elixir paper, 20 parts of cassia twig, and 750 parts of grain liquor.

[0006] Furthermore, the grain liquor is 20-30% sorghum liquor.

[0007] The present invention also discloses a method for preparing a medicinal wine for regulating gout, comprising the following steps, measured in parts by weight: S1: Weigh each raw material according to the ratio, wash with water to remove dust and impurities on the surface, and then dry at room temperature to obtain raw medicinal materials; S2, slicing or grinding the raw medicinal materials into coarse powder, placing them in a sealed non-metallic container such as a ceramic jar or a wide-mouthed glass bottle, and adding grain liquor into the container according to the proportion; S3, place the container in a cool, dark place and seal it for 6 to 12 months, shake the container or stir the medicinal materials frequently during the soaking period, wait for fermentation to obtain the finished wine, and set aside; S4. The finished wine is filtered to obtain a filtrate, instantaneously sterilized, and bottled for shipment to obtain a medicinal wine for treating gout.

[0008] Furthermore, the storage temperature in step S3 is 18-23° C., and the relative humidity is 35-50%.

[0009] The introduction and functions of some raw materials in the formula of the present invention are as follows: Sika deer tendons can strengthen tendons and bones, nourish blood and dredge meridians, produce essence and benefit marrow. They are mainly used to treat strain, heal injuries, strengthen tendons and bones, and replenish yang energy. They are effective in treating long-term rheumatism, joint pain, back pain, fatigue or weakness of tendons and bones, difficulty walking, weakness in hands and feet, cramps in hands and feet, strain from falls, and sore tendons and bones. Deer tendons are rich in collagen, and the blood content of deer tendons is maintained during the processing, so the blood-nourishing effect of deer tendons is enhanced.

[0010] Safflower is the dried flower of Carthamus tinctorius L., a plant of the Asteraceae family. It has the effects of promoting blood circulation and menstruation, dispersing blood stasis and relieving pain. It is used for amenorrhea, dysmenorrhea, lochia retention, lumps and masses, chest pain, abdominal pain due to blood stasis, stabbing pain in the chest and ribs, injuries from falls, and swelling and pain in sores.

[0011] Cuttlebone is salty and astringent in taste and warm in nature. It enters the spleen and kidney meridians. It can astringe and stop bleeding, stop leukorrhea, reduce acid and relieve pain, and astringe dampness and heal sores. It is used for vomiting blood, epistaxis, metrorrhagia, bloody stool, spermatorrhea, leukorrhea, stomachache and acid regurgitation; it can be used externally to treat injury bleeding, eczema, wet sores, and ulcers that do not heal.

[0012] The whole scorpion is pungent in taste and neutral in nature. It belongs to the liver meridian. It has the effects of calming wind and relieving spasms, attacking toxins and dispersing nodules, and dredging meridians and relieving pain. It is mainly used to treat spasms and convulsions, sores and swellings, scrofula and tuberculosis, gangrene, breast abscesses, rheumatism, tendon spasms, and intractable hemicrania.

[0013] Eucommia ulmoides has the functions of nourishing the liver and kidneys, strengthening the tendons and bones, and calming the fetus. It is used for low back and knee pain, weak tendons and bones, and dizziness caused by liver and kidney deficiency and blood stasis.

[0014] Astragalus and astragaloside saponins regulate the body's immune function, promote bone marrow hematopoiesis, and promote vigorous bone marrow growth, and have a significant improvement on renal parenchymal cell metabolism.

[0015] Chuanpo Stone is the root of the small mulberry tree or mulberry tree of the Moraceae family. It has a light taste, slightly bitter, and cool nature. Functions and indications: dispel wind and dampness, promote blood circulation and dredge menstruation. It can treat rheumatic joint pain, jaundice, stranguria, swelling, amenorrhea, hemoptysis due to overwork, injuries from falls, furuncles and carbuncles.

[0016] White peony root has the effects of nourishing blood, softening the liver, calming the liver and relieving pain.

[0017] Red dates can nourish blood, calm the mind, soothe the liver and relieve depression.

[0018] Poria cocos has a sweet and light taste and is neutral in nature. It enters the liver and stomach meridians. It has the effects of detoxifying, removing dampness, and unblocking joints. It is mainly used to treat myrica sylvestris, limb cramps, stranguria and leucorrhea, eczema and itching, carbuncles and sores.

[0019] Platycodon grandiflorum, Platycodon grandiflorum crude saponin has sedative, analgesic and antipyretic effects, can also lower blood sugar, lower cholesterol, and relax smooth muscles. Platycodon grandiflorum saponin has a strong hemolytic effect.

[0020] Panax notoginseng can promote the division and growth of various blood cells, increase their number, promote the proliferation and release of bone marrow cells, increase the number and activity of bone marrow red blood cells, and achieve the function of promoting hematopoiesis. It is a good medicine for removing blood stasis and stopping bleeding, and its medicinal ingredients have the effect of removing blood stasis and stopping bleeding.

[0021] Lingzhi has the effect of nourishing the heart and calming the mind. It can relieve symptoms such as insomnia, fatigue, palpitations, and forgetfulness caused by mental and spiritual malnutrition. Lingzhi can also nourish qi and blood, and has a certain conditioning effect on symptoms such as cold hands and feet, loss of appetite, pale complexion, dizziness, tinnitus, and hair withering caused by qi and blood deficiency. In addition, Lingzhi belongs to the lung meridian, which can nourish lung qi, relieve cough and asthma, and improve symptoms such as cough, sputum, and asthma.

[0022] Thousand-layer paper tastes bitter and sweet, and is cool in nature. It is mainly used to treat lung heat and cough, and has the effect of soothing the liver and stomach.

[0023] Cinnamon twig, nature and flavor: pungent, sweet, warm. Meridians: heart, lung, bladder. Efficacy: sweating and relieving muscles, warming and unblocking meridians, assisting yang and transforming qi, balancing and descending qi. Indications: used for colds, cold pain in the abdomen, amenorrhea due to cold blood, joint pain, phlegm and fluid retention, edema, palpitations, and running pig.

[0024] Compared with the prior art, the present invention has the following beneficial effects: The invention uses sika deer tendons, safflower, cuttlebone, scorpion, eucommia, astragalus, radix scutellariae, white peony root, red dates, tuckahoe, platycodon, notoginseng, ganoderma lucidum, melaleuca and cassia twig as raw materials, and is prepared with sorghum liquor. Through scientific proportioning, the invention can well play the effects of lowering uric acid, promoting blood circulation and unblocking channels, removing dampness and dispersing blood stasis, relieving inflammation and relieving pain, promoting spleen and stomach function and digestion, improving liver and kidney function, enhancing immunity, nourishing and regulating qi, thereby having a good improving and regulating effect on gout, backache and the like, and also has a good effect on improving immunity and replenishing qi. The plant polyphenols in the Chinese medicine of the present invention are easy to combine with proteins and purines in food, and are excreted from the body in the form of such combination, thereby reducing or reducing the excessive absorption and utilization of proteins and purines in food by the human body. In addition, the ortho-hydroxyl groups of the plant polyphenols can produce a chelating reaction with sodium, thereby reducing the content of excessive free sodium ions in the body, thereby achieving the effect of reducing or avoiding the combination of excessive sodium with high uric acid, reducing the amount of sodium urate crystals in the body, and reducing the possibility of gout occurrence or recurrence; the antioxidant components in the Chinese medicine can enhance cell vitality, maintain a normal life cycle, reduce the release of nucleic acid substances due to excessive oxidation, premature aging and premature death of cells, that is, reduce the generation of endogenous purines, thereby reducing the amount of endogenous uric acid. DETAILED DESCRIPTION

[0025] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods. Example 1

[0026] A medicinal wine for regulating gout is composed of the following raw materials in parts by weight: 200g of sika deer tendon, 100g of safflower, 200g of cuttlebone, 50g of whole scorpion, 100g of eucommia, 300g of astragalus, 150g of radix strychnifoliae, 150g of white peony root, 150g of red dates, 150g of poria, 150g of platycodon, 200g of panax notoginseng, 200g of ganoderma lucidum, 150g of kiwano, 200g of cassia twig, and 7500g of sorghum liquor.

[0027] The present invention also discloses a method for preparing a medicinal wine for regulating gout, comprising the following steps, measured in parts by weight: S1: Weigh each raw material according to the ratio, wash with water to remove dust and impurities on the surface, and then dry at room temperature to obtain raw medicinal materials; S2, slicing or grinding the raw medicinal materials into coarse powder, placing them in a sealed non-metallic container such as a ceramic or porcelain jar or a wide-mouthed glass bottle, and adding grain liquor into the container according to the proportion; S3, placing the container in a cool and dark place and sealing it for storage for 6 to 12 months, shaking the container or stirring the medicinal materials frequently during the soaking period, waiting for fermentation to obtain the finished wine, and setting aside; the storage temperature is 18 to 23° C., and the relative humidity is 35 to 50%; S4. The finished wine is filtered to obtain filtrate, instantaneously sterilized, and bottled for shipment to obtain a medicinal wine for treating gout. Example 2

[0028] A medicinal wine for regulating gout is composed of the following raw materials in parts by weight: 150g of sika deer tendon, 50g of safflower, 150g of cuttlebone, 10g of whole scorpion, 50g of eucommia, 250g of astragalus, 100g of radix strychnifoliae, 100g of white peony root, 100g of red dates, 100g of tuckahoe, 100g of platycodon, 150g of notoginseng, 150g of ganoderma lucidum, 100g of kiwano, 150g of cassia twig, and 7000g of sorghum liquor.

[0029] The present invention also discloses a method for preparing a medicinal wine for regulating gout, comprising the following steps, measured in parts by weight: S1: Weigh each raw material according to the ratio, wash with water to remove dust and impurities on the surface, and then dry at room temperature to obtain raw medicinal materials; S2, slicing or grinding the raw medicinal materials into coarse powder, placing them in a sealed non-metallic container such as a ceramic or porcelain jar or a wide-mouthed glass bottle, and adding grain liquor into the container according to the proportion; S3, placing the container in a cool and dark place and sealing it for storage for 6 to 12 months, shaking the container or stirring the medicinal materials frequently during the soaking period, waiting for fermentation to obtain the finished wine, and setting aside; the storage temperature in step S3 is 18 to 23° C., and the relative humidity is 35 to 50%; S4. The finished wine is filtered to obtain filtrate, instantaneously sterilized, and bottled for shipment to obtain a medicinal wine for treating gout. Example 3

[0030] A medicinal wine for regulating gout is composed of the following raw materials in parts by weight: 250g of sika deer tendon, 150g of safflower, 250g of cuttlebone, 50g of whole scorpion, 150g of eucommia bark, 350g of astragalus, 200g of radix strychnifoliae, 200g of white peony root, 200g of red dates, 200g of tuckahoe, 200g of platycodon, 250g of notoginseng, 250g of ganoderma lucidum, 200g of kiwano paper, 250g of cassia twig, and 10000g of sorghum liquor.

[0031] The present invention also discloses a method for preparing a medicinal wine for regulating gout, comprising the following steps, measured in parts by weight: S1: Weigh each raw material according to the ratio, wash with water to remove dust and impurities on the surface, and then dry at room temperature to obtain raw medicinal materials; S2, slicing or grinding the raw medicinal materials into coarse powder, placing them in a sealed non-metallic container such as a ceramic or porcelain jar or a wide-mouthed glass bottle, and adding grain liquor into the container according to the proportion; S3, placing the container in a cool and dark place and sealing it for storage for 6 to 12 months, shaking the container or stirring the medicinal materials frequently during the soaking period, waiting for fermentation to obtain the finished wine, and setting aside; the storage temperature in step S3 is 18 to 23° C., and the relative humidity is 35 to 50%; S4. The finished wine is filtered to obtain filtrate, instantaneously sterilized, and bottled for shipment to obtain a medicinal wine for treating gout.

[0032] Comparative Example In the comparative example, the raw material composition of the medicinal wine for regulating gout in parts by weight is the same as that in Example 1.

[0033] A method for preparing a medicinal wine for treating gout in a comparative example comprises the following steps, measured in parts by weight: S1: Weigh each raw material according to the ratio, wash with water to remove dust and impurities on the surface, and then dry at room temperature to obtain raw medicinal materials; S2, placing the raw medicinal materials in a sealable non-metallic container such as a ceramic jar, a porcelain jar or a wide-mouthed glass bottle, and adding grain liquor into the container according to the proportion; S3, placing the container in a cool and dark place and sealing it for storage for 6 to 12 months, shaking the container or stirring the medicinal materials frequently during the soaking period, waiting for fermentation to obtain the finished wine, and setting aside; the storage temperature in step S3 is 18 to 23° C., and the relative humidity is 35 to 50%; S4. The finished wine is filtered to obtain filtrate, instantaneously sterilized, and bottled for shipment to obtain a medicinal wine for treating gout.

[0034] Test Case The sensory test of the prepared liquor for regulating gout was carried out according to the methods and steps in the national standard GB / T 33404-2016 "Guidelines for Sensory Evaluation of Liquor". The wine tasting cup used for the evaluation is a) with a cup foot; 10 tasters are selected for evaluation in each embodiment, and the selection of personnel meets the content of the basic requirements for personnel in Section 6 of the national standard; the temperature of the tasting room is 23°C and the relative humidity is 50%; the tasting time is 10am, and there is a 15min break between each round; each cup of wine sample is 15mL and the temperature is 25°C. The result is expressed in a nine-point scale, taking the arithmetic mean and retaining one decimal place. The sensory evaluation results of the prepared liquor for regulating gout are shown in Table 2.

[0035] Table 1: Sensory evaluation results of gout-treating blended liquors The higher the score of each sensory characteristic in the sensory evaluation, the better the evaluation of the sensory evaluation. It can be seen from the results in Table 1 that the sensory evaluation of the medicinal wine for regulating gout is excellent, among which the evaluation of Example 1 is relatively the highest. The reason for this result may be that after the raw medicinal materials are sliced ​​or beaten into coarse powder, the effective ingredients and beneficial substances in the raw materials can be better extracted. The presence of effective ingredients or beneficial substances will greatly affect the sensory evaluation of the medicinal wine, and the medicinal wine with the raw materials in Example 1 has the best sensory experience.

[0036] Table 2 Comparison of effect indicators Group Number of cases Onset of Effect Gout treatment time Uric acid lowering time Degree of removing dampness and dispersing blood stasis Anti-inflammatory and analgesic effects Other side effects Example 1 100 About 5 days 3 months 15 days 85% Half a year No toxic side effects, safe and efficient Example 2 100 About 5 days 3 months 15 days 80% Half a year No toxic side effects, safe and efficient Example 3 100 About 5 days 3 months 15 days 80% Half a year No toxic side effects, safe and efficient Comparative Example 100 About 10 days 3 months 10 days 70% 4 months No toxic side effects, safe and effective Chinese medicine oral group 100 About 15 days long 3 months 50% 3 months Minor side effects, affecting gastrointestinal function Western medicine treatment group 100 About 15 days long 1 month 40% 2 months Side effects are significant, hormones, chemicals It can be seen from the results of Table 2 that the medicinal wine for regulating gout has a fast onset time, a long treatment time for gout, can well play the effects of lowering uric acid, promoting blood circulation and unblocking collaterals, removing dampness and dispersing blood stasis, anti-inflammatory and analgesic, and can promote spleen and stomach function digestion, improve liver and kidney function, enhance immunity, nourish and regulate qi. The medicinal wine of the present invention is a biological preparation, has no toxic side effects, is safe and efficient.

[0037] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A medicinal wine for treating gout, characterized in that: The invention is composed of the following raw materials in parts by weight: 15-25 parts of sika deer tendons, 5-15 parts of safflower, 15-25 parts of cuttlebone, 1-10 parts of scorpion, 5-15 parts of eucommia bark, 25-35 parts of astragalus, 10-20 parts of radix strychnifoliae, 10-20 parts of white peony root, 10-20 parts of red dates, 10-20 parts of tuckahoe, 10-20 parts of platycodon, 15-25 parts of notoginseng, 15-25 parts of ganoderma lucidum, 10-20 parts of melaleuca, 15-25 parts of cassia twig and 700-1000 parts of grain liquor.

2. The medicinal wine for treating gout according to claim 1, characterized in that: The invention is composed of the following raw materials in parts by weight: 20 parts of sika deer tendons, 10 parts of safflower, 20 parts of cuttlebone, 5 parts of scorpion, 10 parts of eucommia bark, 30 parts of astragalus, 15 parts of radix scutellariae, 15 parts of white peony root, 15 parts of red dates, 15 parts of tuckahoe, 15 parts of platycodon grandiflorum, 20 parts of panax notoginseng, 20 parts of ganoderma lucidum, 15 parts of melaleuca, 20 parts of cassia twig, and 750 parts of grain liquor.

3. A medicinal wine for treating gout according to any one of claims 1-2, characterized in that: The grain liquor is 20-30% sorghum liquor.

4. The method for preparing a medicinal wine for treating gout according to claim 1, characterized in that: The method comprises the following steps, in parts by weight: S1: Weigh each raw material according to the ratio, wash with water to remove dust and impurities on the surface, and then dry at room temperature to obtain raw medicinal materials; S2, slicing or grinding the raw medicinal materials into coarse powder, placing them in a sealed non-metallic container such as a ceramic or porcelain jar or a wide-mouthed glass bottle, and adding grain liquor into the container according to the proportion; S3, place the container in a cool, dark place and seal it for 6 to 12 months, shake the container or stir the medicinal materials frequently during the soaking period, wait for fermentation to obtain the finished wine, and set aside; S4. The finished wine is filtered to obtain filtrate, instantaneously sterilized, and bottled for shipment to obtain a medicinal wine for treating gout.

5. A method for preparing a medicinal wine for treating gout according to claim 4, characterized in that: The storage temperature in step S3 is 18-23° C. and the relative humidity is 35-50%.

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