Composition for treating allergic papule and urticaria and preparation method of tincture

Abstract

The invention relates to a composition for treating allergic papule and urticaria and a preparation method of a tincture. The composition is prepared from the following components in parts by weight: 20-40 parts of raw radix stemonae, 20-40 parts of pepper, 40-60 parts of rheum officinale, 20-40 parts of fructus cnidii and 2-4 parts of borneol. The composition has the effects of clearing away heat and toxic materials, resisting allergy and relieving swelling and itching, has an effect on common skin diseases of children, has a peculiar effect on allergic papule and urticaria, and has the total effective rate of 97% or above.

Description

Technical Field

[0001] The invention relates to the field of medicine, and more particularly to a composition for treating allergic papules and urticaria and a preparation method of a tincture. Background Art

[0002] Children's skin is delicate and more vulnerable to some external injuries, so the possibility of suffering from skin diseases is also relatively high. At present, common skin diseases in children include heat rash, eczema, herpes zoster, contact dermatitis, allergic dermatitis, neurodermatitis, urticaria (urticaria or wind pimples), papular urticaria (insect bite dermatitis), etc. Different types of skin diseases have different treatment methods. For the treatment of allergic papules and urticaria, Western medicine mainly uses antihistamines, such as chlorpheniramine, cyproheptadine, etc. In addition, immunosuppressants such as glucocorticoids and cyclosporine A can also be used. Traditional Chinese medicine treatment mainly focuses on dispelling wind and relieving itching, clearing heat and detoxifying. However, existing Western medicine treatment methods have certain risks and contraindications and are not suitable for children; and the treatment effect of traditional Chinese medicine is poor, especially for allergic papules and urticaria. Summary of the invention

[0003] The purpose of the present invention is to provide a composition for treating allergic papules and urticaria. The composition has the effects of clearing away heat and detoxifying, resisting allergy, reducing swelling and relieving itching. It is effective for common skin diseases in children and has a miraculous effect on allergic papules and urticaria, with a total effective rate of more than 97%.

[0004] To achieve the above object, the present invention adopts the following technical solution:

[0005] A composition for treating allergic papules and urticaria, the composition comprises 20-40 parts by weight of stemona radix, 20-40 parts by weight of zanthoxylum bungeanum, 40-60 parts by weight of rhubarb, 20-40 parts by weight of cnidium monnieri and 2-4 parts by weight of borneol.

[0006] As a preferred embodiment of the present invention, the composition is composed of 20-30 parts by weight of Stemona tuberosa, 30-40 parts by weight of Zanthoxylum bungeanum, 40-50 parts by weight of Rhubarb, 30-40 parts by weight of Cnidium monnieri, and 2-4 parts by weight of Borneol.

[0007] As a preferred embodiment of the present invention, the composition is composed of 30 parts by weight of Stemona tuberosa, 40 parts by weight of Zanthoxylum bungeanum, 40 parts by weight of Rhubarb, 40 parts by weight of Cnidium monnieri and 3 parts by weight of Borneol.

[0008] A composition for treating allergic papules and urticaria, the composition comprises 20-40 parts by weight of stemona radix, 20-40 parts by weight of zanthoxylum bungeanum, 40-60 parts by weight of rhubarb, 20-40 parts by weight of cnidium monnieri, 2-4 parts by weight of borneol and 6-8 parts by weight of metronidazole powder.

[0009] As a preferred embodiment of the present invention, the composition is composed of 20-30 parts by weight of Stemona tuberosa, 30-40 parts by weight of Zanthoxylum bungeanum, 40-50 parts by weight of Rhubarb, 30-40 parts by weight of Cnidium monnieri, 2-4 parts by weight of Borneol, and 6-8 parts by weight of metronidazole powder.

[0010] As a preferred embodiment of the present invention, the composition is composed of 30 parts by weight of Stemona tuberosa, 40 parts by weight of Zanthoxylum bungeanum, 40 parts by weight of Rhubarb, 40 parts by weight of Cnidium monnieri, 3 parts by weight of Borneol, and 6-8 parts by weight of metronidazole powder.

[0011] The present invention also provides a method for preparing a tincture for treating allergic papules and urticaria, the method comprising the following steps:

[0012] Step 1. Dry and grind rhubarb, raw stemona, cnidium monnieri and Zanthoxylum bungeanum into powder;

[0013] Step 2. Dissolve the borneol with alcohol and pour it into the container with powder;

[0014] Step 3. Add alcohol to the container containing the powder and soak it for 5-10 days, filter it, soak the residue in alcohol for another 5-10 days, filter it, combine the two filtrates, dilute it with alcohol and make up the volume, and package it.

[0015] As a preferred embodiment of the present invention, the alcohol used in step 2 and step 3 is 75% alcohol.

[0016] As a preferred embodiment of the present invention, in step 2, borneol and metronidazole powder are dissolved in alcohol at the same time and then poured into a container containing the powder.

[0017] As the preferred embodiment of the present invention, in step 1, 300g of raw stemona, 400g of zanthoxylum bungeanum, 400g of rhubarb and 400g of cnidium monnieri are added, and in step 2, 30g of borneol is added, and in step 3, 2500ml of 75% alcohol is first added and soaked for 7 days, filtered, and the filter residue is soaked in 2000ml of 75% alcohol for another 7 days, filtered, the two filtrates are combined, diluted to 4000ml with 75% alcohol, and packaged to obtain the product.

[0018] Advantages and beneficial effects of the present invention:

[0019] (1) The synergistic effect of Cnidium monnieri and Zanthoxylum bungeanum in the composition provided by the present invention can inhibit the release of histamine; Rhubarb can clear the heat and toxicity in the upper part of the body, and the anthraquinone derivatives in Rhubarb can inhibit nonspecific immune function and exert immune regulation function; Stemona radix can moisten the lungs, relieve qi and relieve cough, kill insects and kill lice, and the combination of Stemona radix and Rhubarb can exert the effects of clearing heat and detoxifying, killing insects and relieving itching; Borneol can promote transdermal absorption, thereby enhancing the effects of clearing heat and detoxifying, anti-allergic, and relieving itching; in addition, Borneol also has the effects of antibacterial and antifungal, anti-inflammatory and analgesic. It, together with Cnidium monnieri, Zanthoxylum bungeanum, Rhubarb and Stemona radix, has the effects of clearing heat and detoxifying, anti-allergic, reducing swelling and relieving itching. The composition is effective for common skin diseases in children, and has a miraculous effect on allergic papules and urticaria, with a total effective rate of more than 97%.

[0020] (2) Metronidazole can also be added to the composition provided by the present invention. Metronidazole has antibacterial and antiparasitic effects. Although the addition of metronidazole has little effect on children with allergic papules and urticaria, it can increase the total effective rate of inflammatory papules, pustules and papular urticaria.

[0021] (3) The amount of each component added to the composition provided by the present invention has a significant difference in the therapeutic effect on skin diseases with different symptoms. When the formula is composed of 40 parts by weight of Stemona tuberosa, 20 parts by weight of Zanthoxylum bungeanum, 60 parts by weight of Rhubarb, 20 parts by weight of Cnidium monnieri, 2 parts by weight of Borneol, and 8 parts by weight of metronidazole powder, it has a significant therapeutic effect on papular urticaria caused by insect bites, with a total effective rate of 85.7%. When the formula is adjusted to 30 parts by weight of Stemona tuberosa, 40 parts by weight of Zanthoxylum bungeanum, 40 parts by weight of Rhubarb, 40 parts by weight of Cnidium monnieri, and 3 parts by weight of Borneol, it has a miraculous effect on allergic papules and urticaria, with a total effective rate of more than 97%. At the same time, the total effective rate for papular urticaria caused by insect bites can also reach about 80%. DETAILED DESCRIPTION

[0022] The present invention discloses a composition for treating allergic papules and urticaria and a method for preparing a tincture. Those skilled in the art can refer to the contents of this article and appropriately improve the component parameters or process parameters to achieve the above. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art and are deemed to be included in the scope of protection of the present invention.

[0023] Example 1

[0024] This embodiment provides a composition for treating allergic papules and urticaria, wherein the composition is composed of 30 parts by weight of Stemona tuberosa, 40 parts by weight of Zanthoxylum bungeanum, 40 parts by weight of Rhubarb, 40 parts by weight of Cnidium monnieri, and 3 parts by weight of Borneol.

[0025] The composition provided in this embodiment needs to be prepared into an external preparation for wet compress and external application in actual use, such as tincture, ointment, gel, etc. Among the above dosage forms, tincture has the advantages of simple preparation, fast absorption, and rapid efficacy, so tincture is preferred.

[0026] Specifically, the preparation method of the tincture comprises the following steps:

[0027] Step 1. Rhubarb (400g), Stemona tuberosa (300g), Cnidium monnieri (400g), and Zanthoxylum bungeanum (400g) are dried and crushed into powder;

[0028] Step 2. Dissolve borneol (30 g) in 75% alcohol and pour into the container containing the powder;

[0029] Step 3. Add 2500ml of 75% alcohol to the container containing the powder and soak for 7 days, filter, soak the residue with 2000ml of 75% alcohol for another 7 days, filter, combine the two filtrates, dilute with 75% alcohol and make up to 4000ml, and package.

[0030] Example 2

[0031] This embodiment provides a composition for treating allergic papules and urticaria, wherein the composition is composed of 40 parts by weight of Stemona tuberosa, 20 parts by weight of Zanthoxylum bungeanum, 60 parts by weight of Rhubarb, 20 parts by weight of Cnidium monnieri, 2 parts by weight of Borneol, and 8 parts by weight of metronidazole powder.

[0032] The composition provided in this embodiment needs to be prepared into an external preparation for wet compress and external application in actual use, such as tincture, ointment, gel, etc. Among the above dosage forms, tincture has the advantages of simple preparation, fast absorption, and rapid efficacy, so tincture is preferred.

[0033] Specifically, the preparation method of the tincture comprises the following steps:

[0034] Step 1. Rhubarb (600g), Stemona tuberosa (400g), Cnidium monnieri (200g), and Zanthoxylum bungeanum (200g) are dried and crushed into powder;

[0035] Step 2. Dissolve borneol (30 g) and metronidazole powder (80 g) in 75% alcohol and pour into the container containing the powder;

[0036] Step 3. Add 2500ml of 75% alcohol to the container containing the powder and soak for 7 days, filter, soak the residue with 2000ml of 75% alcohol for another 7 days, filter, combine the two filtrates, dilute with 75% alcohol and make up to 4000ml, and package.

[0037] Example 3

[0038] The present embodiment provides a composition for treating allergic papules and urticaria, wherein the composition is composed of 30 parts by weight of Stemona tuberosa, 40 parts by weight of Zanthoxylum bungeanum, 40 parts by weight of Rhubarb, 40 parts by weight of Cnidium monnieri, 3 parts by weight of Borneol, and 8 parts by weight of metronidazole powder.

[0039] It should be noted that the composition provided by the present invention can be added with or without metronidazole powder according to the patient's symptoms during clinical medication, and the amount of metronidazole powder can be appropriately increased or decreased. For example, for inflammatory papules and pustules, metronidazole powder can be reduced to 6 parts by weight, and rhubarb can be added to 50 parts by weight; for papular urticaria, metronidazole powder can be added to 8 parts by weight, and raw stemona can be added to 40 parts by weight; of course, the amount of each raw material in the above composition needs to be controlled within the following range no matter how it is added or decreased:

[0040] 20-40 weight parts of raw stemona, 20-40 weight parts of zanthoxylum bungeanum, 40-60 weight parts of rhubarb, 20-40 weight parts of cnidium monnieri, 2-4 weight parts of borneol, and 6-8 weight parts of metronidazole powder.

[0041] The synergistic effect of Cnidium monnieri and Zanthoxylum bungeanum in the composition provided by the present invention can inhibit the release of histamine; Rhubarb can clear the heat and toxicity in the upper part of the body, and the anthraquinone derivatives in Rhubarb can inhibit nonspecific immune function and exert immune regulation function; Stemona tuberosum can moisten the lungs, relieve qi and relieve cough, kill insects and kill lice, and the combination of Stemona tuberosum and Rhubarb can exert the effects of clearing away heat and detoxifying, killing insects and relieving itching; Borneol can promote transdermal absorption, thereby enhancing the effects of clearing heat and detoxifying, anti-allergic, and relieving itching; in addition, Borneol also has the effects of antibacterial and antifungal, anti-inflammatory and analgesic, and it, together with Cnidium monnieri, Zanthoxylum bungeanum, Rhubarb and Stemona tuberosum, has the effects of clearing heat and detoxifying, anti-allergic, reducing swelling and relieving itching. The prescription has been used in Jilin Children's Hospital for many years and is effective for common skin diseases in children, and has a miraculous effect on allergic papules and urticaria. The therapeutic effect of the composition of the present invention is illustrated by clinical data as follows:

[0042] 1. General information:

[0043] A total of 240 children with skin diseases (118 cases of allergic papules and urticaria, 84 cases of papular urticaria, and 38 cases of inflammatory papules) were selected from the Dermatology Outpatient Department of Jilin Children's Hospital (April 2019 to April 2022) and randomly divided into three groups, 80 cases in each group; among them, treatment group I: 34 males, 46 females, 3 cases under 1 year old, 37 cases 1-3 years old, 31 cases 4-7 years old, 9 cases 8-16 years old, 40 cases of allergic papules and urticaria, 26 cases of papular urticaria, and 14 cases of inflammatory papules; treatment group II: male There were 38 cases in treatment group 2, including 42 females, 2 cases under 1 year old, 40 cases between 1 and 3 years old, 30 cases between 4 and 7 years old, 8 cases between 8 and 16 years old, 40 cases with allergic papules and urticaria, 28 cases with papular urticaria, and 12 cases with inflammatory papules; Treatment group 3: 37 males and 43 females, 2 cases under 1 year old, 38 cases between 1 and 3 years old, 32 cases between 4 and 7 years old, 8 cases between 8 and 16 years old, 38 cases with allergic papules and urticaria, 30 cases with papular urticaria, and 12 cases with inflammatory papules; There was no significant difference in gender, age, and condition among the three groups, and the three groups were comparable.

[0044] 2. Treatment methods:

[0045] Treatment group 1: The tincture of Example 1 was applied or sprayed on the affected area three times a day for seven consecutive days as a course of treatment, and no other drugs were used.

[0046] Treatment Group 2: The tincture of Example 2 was applied or sprayed on the affected area three times a day for seven consecutive days as a course of treatment, and no other drugs were used.

[0047] Treatment group 3: The tincture of Example 3 was applied or sprayed on the affected area three times a day for seven consecutive days as a course of treatment, and no other drugs were used.

[0048] 3. Observation of therapeutic effects

[0049] Cure: Skin lesions completely disappear or only leave traces, and subjective symptoms disappear;

[0050] Markedly effective: skin lesions subsided by more than 60%, and subjective symptoms were significantly alleviated;

[0051] Effective: Skin lesions subsided by more than 60% to 30%, and subjective symptoms were alleviated;

[0052] Ineffective: No significant change in symptoms, not meeting the above criteria.

[0053] 4. Treatment results:

[0054] Treatment group 1 and treatment group 3 have miraculous effects on allergic papules and urticaria, with a total effective rate of over 97%, which is significantly higher than that of treatment group 2; and the therapeutic effect of treatment group 2 on papular urticaria is better than that of treatment group 1, and slightly better than that of treatment group 3; and the above three prescriptions all have therapeutic effects on inflammatory papules, but the effects are general, and the therapeutic effect of treatment group 3 is better than that of treatment group 1 and treatment group 2. For details, please see Table 1.

[0055] Table 1 Comparison of comprehensive efficacy between treatment group 1, treatment group 2 and treatment group 3 [cases (%)]

[0056]

[0057] The above description is a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A composition for treating allergic papules and urticaria, characterized in that: The composition consists of 20-40 parts by weight of stemona, 20-40 parts by weight of zanthoxylum bungeanum, 40-60 parts by weight of rhubarb, 20-40 parts by weight of cnidium monnieri and 2-4 parts by weight of borneol.

2. A composition for treating allergic papules and urticaria according to claim 1, characterized in that: The composition consists of 20-30 parts by weight of stemona, 30-40 parts by weight of zanthoxylum bungeanum, 40-50 parts by weight of rhubarb, 30-40 parts by weight of cnidium monnieri and 2-4 parts by weight of borneol.

3. A composition for treating allergic papules and urticaria according to claim 1, characterized in that: The composition consists of 30 parts by weight of stemona, 40 parts by weight of zanthoxylum bungeanum, 40 parts by weight of rhubarb, 40 parts by weight of cnidium monnieri and 3 parts by weight of borneol.

4. A composition for treating allergic papules and urticaria, characterized in that: The composition consists of 20-40 parts by weight of stemona, 20-40 parts by weight of zanthoxylum bungeanum, 40-60 parts by weight of rhubarb, 20-40 parts by weight of cnidium monnieri, 2-4 parts by weight of borneol and 6-8 parts by weight of metronidazole powder.

5. A composition for treating allergic papules and urticaria according to claim 4, characterized in that: The composition consists of 20-30 parts by weight of stemona, 30-40 parts by weight of zanthoxylum bungeanum, 40-50 parts by weight of rhubarb, 30-40 parts by weight of cnidium monnieri, 2-4 parts by weight of borneol and 6-8 parts by weight of metronidazole powder.

6. A composition for treating allergic papules and urticaria according to claim 4, characterized in that: The composition consists of 30 parts by weight of stemona, 40 parts by weight of zanthoxylum bungeanum, 40 parts by weight of rhubarb, 40 parts by weight of cnidium monnieri, 3 parts by weight of borneol and 6-8 parts by weight of metronidazole powder.

7. A method for preparing a tincture for treating allergic papules and urticaria, characterized in that: The method comprises the following steps: Step 1. Dry and grind rhubarb, raw stemona, cnidium monnieri and Zanthoxylum bungeanum into powder; Step 2. Dissolve the borneol with alcohol and pour it into the container with powder; Step 3. Add alcohol to the container containing the powder and soak it for 5-10 days, filter it, soak the residue in alcohol for another 5-10 days, filter it, combine the two filtrates, dilute it with alcohol and make up the volume, and package it.

8. The method for preparing a tincture for treating allergic papules and urticaria according to claim 7, characterized in that: The alcohol used in step 2 and step 3 is 75% alcohol.

9. The method for preparing a tincture for treating allergic papules and urticaria according to claim 7, characterized in that: In the step 2, borneol and metronidazole powder are dissolved in alcohol at the same time and then poured into a container containing the powder.

10. The method for preparing a tincture for treating allergic papules and urticaria according to claim 8, characterized in that: In the step 1, 300g of raw stemonae, 400g of zanthoxylum bungeanum, 400g of rhubarb and 400g of cnidium monnieri are added; in the step 2, 30g of borneol is added; in the step 3, 2500ml of 75% alcohol is first added and soaked for 7 days, filtered, the filter residue is soaked in 2000ml of 75% alcohol for another 7 days, filtered, the two filtrates are combined, diluted to 4000ml with 75% alcohol, and packaged to obtain the product.

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